CN110478477A - 一种促进女性生殖健康的中药生物制剂及其制备方法 - Google Patents
一种促进女性生殖健康的中药生物制剂及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种促进女性生殖健康的中药生物制剂及其制备方法,包括如下原料:苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄、蔓越莓、蜂胶、溶菌酶、薄荷脑和大豆肽。本发明的有益效果为:本发明的中药生物制剂采用纯天然中药成份,对于阴道粘膜无刺激,不会破坏阴道洁净环境,清除阴道异味,消除瘙痒、炎症、糜烂,滋养阴道,具有抑菌、抗菌、抗病毒等作用,不仅能抑制细菌的生长和繁殖,而且能够修复阴道粘膜和宫颈损伤,同时还能够促进阴道恢复弹性紧致,保护卵巢,提高机体免疫力,促进女性生殖健康。
Description
技术领域
本发明属于中药技术领域,具体涉及一种促进女性生殖健康的中药生物制剂及其制备方法。
背景技术
近年来妇科阴道疾病已经成为严重危害女性健康的常见病和多发病,据统计,目前世界上患有妇科阴道疾病的患者数占据女性成年人口的80%以上,女性平均每人每年使用妇科药物在5次以上。妇女下腹坠胀,脂肪沉积,妊娠斑,外阴瘙痒,阴唇干瘪萎缩,发黑或白斑,内阴道括约肌松弛老化,带下异常,异味瘙痒,引起性交不敏感,性生活冷淡,或阴道干涩引起性交疼痛出血等问题是妇科临床常见性疾病。
妇科阴道疾病是女性受外源病毒、病原体细菌等因素引发感染造成的阴道细胞粘膜组织损伤性的疾病,由于女性阴道表皮组织细胞是一类具有分泌能力的细胞,它具有分泌自洁净物、分泌雌性激素、分泌内分泌激素、分泌免疫成分以及分泌润滑液等诸多功能,但以往在治疗此类疾病的同时,往往由于使用的药物具有一定的刺激性,更多的是由于药物制剂不能被阴道粘膜细胞所吸收,留有药物残渣,对阴道造成二次污染,导致阴道粘膜细胞分泌功能的衰减或下降,使得女性过早出现干涩、阴道细胞分泌功能下降、性生活困难以及过早绝经等现象。
目前治疗女性生殖健康的药物众多,特别是中西医制剂在临床上具有良好的疗效,但是由于妇科阴道疾病的发病率高且病理机制较为复杂,虽然具有消炎、抗菌的作用,但是容易对阴道粘膜细胞产生刺激,阴道失去了粘膜分泌液的保护,更易造成感染细菌和病毒。
鉴于以上原因,特提出本发明。
发明内容
为了解决现有技术存在的以上问题,本发明提供了一种促进女性生殖健康的中药生物制剂及其制备方法,本发明的中药生物制剂采用纯天然中药成份,对于阴道粘膜无刺激,不会破坏阴道洁净环境,清除阴道异味,消除瘙痒,具有抑菌、抗菌、病毒等作用。
为了实现上述目的,本发明采用如下技术方案:
一种促进女性生殖健康的中药生物制剂,包括如下原料:苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄、蔓越莓、蜂胶、溶菌酶、薄荷脑和大豆肽。
进一步的,按照重量份,包括如下原料:苦参16-20重量份、蛇床子16-20重量份、五倍子14-18重量份、芦荟10-16重量份、当归6-10重量份、黄柏4-8重量份、红花3-7重量份、菟丝子3-7重量份、玫瑰茄1-5重量份、蔓越莓1-5重量份、蜂胶1-3重量份、溶菌酶0.5-2.5重量份、薄荷脑0.2-0.24重量份和大豆肽0.03-0.07重量份。
进一步的,按照重量份,包括如下原料:苦参18重量份、蛇床子18重量份、五倍子16重量份、芦荟13重量份、当归8重量份、黄柏6重量份、红花5重量份、菟丝子5重量份、玫瑰茄3重量份、蔓越莓3重量份、蜂胶2重量份、溶菌酶1.5重量份、薄荷脑0.22重量份和大豆肽0.05重量份。
苦参为豆科植物苦参的干燥根,春、秋二季采挖,除去根头和小支根,洗净,干燥,或趁鲜切片,干燥。其苦,寒。有清热燥湿,杀虫,利尿之功。用于热痢,便血,黄疸尿闭,赤白带下,阴肿阴痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风,外治滴虫性阴道炎。
蛇床子燥湿,祛风,杀虫,温肾壮阳。用于阳痿、宫冷、寒湿带下、湿痹腰痛;外治外阴湿疹、妇人阴痒、滴虫性阴道炎。
五倍子的光谱抗菌作用较强。五倍子的煎剂对很多的菌种有不同程度的抑制作用。其中包括金黄色葡萄球菌、伤寒杆菌、绿脓杆菌,此外还包括痢疾杆菌、肺炎球菌、炭疽杆菌、大肠杆菌以及几种病原弧菌(鳗弧菌、溶藻弧菌、副溶血弧菌、哈氏弧菌)等。
芦荟具有杀菌作用,抗炎作用,湿润美容作用,健胃下泄作用,强心活血作用,免疫和再生作用,免疫与抗肿瘤作用,解毒作用,抗衰老作用,镇痛、镇静作用,防晒作用。
当归补血;活血;调经止痛;润燥滑肠。主血虚诸证;月经不调;经闭;痛经;症瘕结聚;崩漏;虚寒腹痛;痿痹;肌肤麻木;肠燥便难;赤痢后重;痈疽疮疡;跌扑损伤。
黄柏清热燥湿,泻火除蒸,解毒疗疮。用于湿热泻痢,黄疸尿赤,带下阴痒,热淋涩痛,脚气痿躄,骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹湿疮。盐黄柏滋阴降火。用于阴虚火旺,盗汗骨蒸。
红花活血通经,散瘀止痛,有助于治经闭、痛经、恶露不行、胸痹心痛、瘀滞腹痛、胸胁刺痛、跌打损伤、疮疡肿痛疗效。有活血化瘀,散湿去肿的功效,避免孕妇使用,否则会造成流产。
菟丝子甘、温,归肾、肝、脾经,具有滋补肝肾、固精缩尿、安胎、明目、止泻之功效,始载《神农本草经》,被列为上品。甘味一般具有滋补作用,甘辛微温,禀气中和,既可补阳,又可益阴,具有温而不燥,补而不滞的特点。固精安胎与性激素样作用。中医认为肾为先天之本,内寓元阴与元阳,是人体生殖发育的根源,脏腑机能活动的原动力。
玫瑰茄敛肺止咳,降血压,解酒,清热去火,利尿。
蔓越莓又叫做蔓越橘,属于杜鹃花科的植物,主要生长在北半球的酸性泥炭土壤中。蔓越莓具有美容养颜、抗氧化、利尿解毒、保护心血管等功效,可以有效的预防泌尿系统感染、幽门螺旋杆菌感染,可以预防胃溃疡、膀胱炎等疾病,经常食用蔓越莓还可以起到抗衰老、防癌、抗老化、预防老年痴呆、降血压等功效。
蜂胶具有广泛的药理学活性,如抗菌、抗病毒、抗病原虫、抗氧化、抗癌、麻醉、创伤修复、消炎、免疫调节、预防龋齿、心血管保护等。
溶菌酶作为一种存在于人体正常体液及组织中的非特异性免疫因素,具有多种药理作用,它具有抗菌、抗病毒、抗肿瘤的功效,医用溶菌酶其适应症为出血、血尿、血痰和鼻炎等。
薄荷脑的主要成分就是薄荷油,它具有消炎杀菌止痒的中药功效,平时人们在工业生产中可以用它制作花露水或者香皂以及牙膏等,多种日用品,把它涂抹在肌肤以后有明显清凉感,而且能消除皮肤炎症,在被蚊虫叮咬以后,及时涂抹含有薄荷脑的花露水,还能让红肿的症状很快减轻。
大豆肽可以促进蛋白质,降低血压,血脂和胆固醇。可以调节血糖,促进血液循环,脂质代谢。可以改善人体的吸收及消化功能,改善小肠组织结构。可以润肠通便,改善肝脏功能,有养肝护肝的作用。可以抗疲劳,增强抵抗力及免疫力。可以抗氧化,还有保湿的作用。还可以促进能量代谢,有减肥功能。
本发明的中药生物制剂中蛇床子、五倍子、黄柏和菟丝子的协同作用,不仅能够有效的抑制金黄色葡萄球菌、白色念珠菌和大肠杆菌的生长和繁殖,而且能够修复阴道粘膜,防止微生物再感染,同时还能够维持阴道正常菌群和酸碱平衡,促进女性生殖健康。
进一步的,所述的中药生物制剂的剂型为液体冲洗剂、片剂或凝胶。
本发明的制备的液体冲洗剂使用方法为将液体冲洗剂与水按照体积比为1:4-6比例兑配制成,直接冲洗阴部即可,一天2次。
片剂为每片650mg,使用方法,直接将片剂放入女性阴道内,每日一片。
凝胶为每支3.5g,使用方法,取本品一支,去除辅助器前端的保护帽,经凝胶推至阴道深处,撤出辅助器,保持臀部向上静躺10-15分钟,一天一次。
一种所述的促进女性生殖健康的中药生物制剂的制备方法,包括如下步骤:
(1)按照各原料的重量称取备用;
(2)将备用的苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄和蔓越莓十味中药分别分两次加入蒸馏水煎煮两次,两次煎煮分别过滤,合并两次滤液;
(3)将合并的两次滤液真空浓缩成清膏,然后加入可接受的药用辅料,然后加入备用的蜂胶、溶菌酶、薄荷脑和大豆肽均质,得到制剂。
进一步的,步骤(2)中第一次煎煮水的重量为十味中药总重量的6-10倍,第一次煎煮时间为1.5-2.5小时。
进一步的,步骤(2)中第一次煎煮水的重量为十味中药总重量的8倍,第一次煎煮时间为2小时。
进一步的,步骤(2)中第二次煎煮水的重量为十味中药总重量的4-8倍,第二次煎煮时间为1-2小时。
进一步的,步骤(2)中第二次煎煮水的重量为十味中药总重量的6倍,第二次煎煮时间为1.5小时。
进一步的,步骤(3)中浓缩的清膏在60℃下,相对密度为1.05g/cm3。
与现有技术相比,本发明的有益效果为:
(1)本发明的中药生物制剂采用纯天然中药成份,对于阴道粘膜无刺激,不会破坏阴道洁净环境,清除阴道异味,消除瘙痒、炎症、糜烂,滋养阴道,具有抑菌、抗菌、抗病毒等作用,不仅能抑制细菌的生长和繁殖,而且能够修复阴道粘膜和宫颈损伤,同时还能够促进阴道恢复弹性紧致,保护卵巢,提高机体免疫力,促进女性生殖健康;
(2)本发明的中药生物制剂温和不刺激,无毒副作用,凝胶制剂无需进行稀释,直接推入阴道即可,使用方便,本发明的中药生物制剂制备方法简单,操作方便,可以大规模使用,充分的将各原料的有效成分提取出来,提高了生产效率。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范围。
实施例1片剂
一种促进女性生殖健康的中药生物制剂,包括如下原料:苦参16g、蛇床子16g、五倍子14g、芦荟10g、当归6g、黄柏4g、红花3g、菟丝子3g、玫瑰茄1g、蔓越莓1g、蜂胶1g、溶菌酶0.5g、薄荷脑0.2g和大豆肽0.03g。
片剂的制备方法为:
(1)按照各原料的重量称取备用;
(2)将备用的苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄和蔓越莓十味中药分别分两次加入蒸馏水煎煮两次,第一次煎煮水的重量为十味中药总重量的6倍,第一次煎煮时间为1.5小时,第二次煎煮水的重量为十味中药总重量的4倍,第二次煎煮时间为1小时,两次煎煮分别过滤,合并两次滤液;
(3)将合并的两次滤液真空浓缩成清膏,清膏在60℃下,相对密度为1.05g/cm3,将清膏真空干燥,得到干性浸膏粉,将干性浸膏粉研磨成细粉,加入β-环糊精,干性浸膏粉与β-环糊精的重量比为1:0.2,然后加入备用的蜂胶、溶菌酶、薄荷脑和大豆肽均质,干燥,用乙醇制粒,压片,得到片剂。
实施例2液体冲洗剂
一种促进女性生殖健康的中药生物制剂,包括如下原料:苦参20g、蛇床子20g、五倍子18g、芦荟16g、当归10g、黄柏8g、红花7g、菟丝子7g、玫瑰茄5g、蔓越莓5g、蜂胶3g、溶菌酶2.5g、薄荷脑0.24g和大豆肽0.07g。
液体冲洗剂的制备方法为:
(1)按照各原料的重量称取备用;
(2)将备用的苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄和蔓越莓十味中药分别分两次加入蒸馏水煎煮两次,第一次煎煮水的重量为十味中药总重量的10倍,第一次煎煮时间为2.5小时,第二次煎煮水的重量为十味中药总重量的8倍,第二次煎煮时间为2小时,两次煎煮分别过滤,合并两次滤液;
(3)将合并的两次滤液真空浓缩成清膏,清膏在60℃下,相对密度为1.05g/cm3,再加入纯净水搅拌均匀,纯净水与清膏的质量比为10:0.7,然后加入备用的蜂胶、溶菌酶、薄荷脑和大豆肽均质,得到液体冲洗剂。
实施例3凝胶
一种促进女性生殖健康的中药生物制剂,包括如下原料:苦参18g、蛇床子18g、五倍子16g、芦荟13g、当归8g、黄柏6g、红花5g、菟丝子5g、玫瑰茄3g、蔓越莓3g、蜂胶2g、溶菌酶1.5g、薄荷脑0.22g和大豆肽0.05g。
凝胶的制备方法为:
(1)按照各原料的重量分别称取备用;
(2)将备用的苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄和蔓越莓十味中药分别分两次加入蒸馏水煎煮两次,第一次煎煮水的重量为十味中药总重量的8倍,第一次煎煮时间为2.5小时,第二次煎煮水的重量为十味中药总重量的6倍,第二次煎煮时间为2小时,两次煎煮分别过滤,合并两次滤液;
(3)将合并的两次滤液真空浓缩成清膏,清膏在60℃下,相对密度为1.05g/cm3,加入凝胶赋形剂卡波姆,在均质机中制成凝胶,然后加入备用的蜂胶、溶菌酶、薄荷脑和大豆肽均质半小时,将配好的凝胶用自动凝胶灌装机灌装,得到凝胶。
实施例4凝胶
一种促进女性生殖健康的中药生物制剂,包括如下原料:苦参19g、蛇床子17g、五倍子15g、芦荟15g、当归9g、黄柏5g、红花8g、菟丝子4g、玫瑰茄4g、蔓越莓4g、蜂胶1.5g、溶菌酶2.0g、薄荷脑0.23g和大豆肽0.06g。
凝胶的制备方法为:
(1)按照各原料的重量分别称取备用;
(2)将备用的苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄和蔓越莓十味中药分别分两次加入蒸馏水煎煮两次,第一次煎煮水的重量为十味中药总重量的9倍,第一次煎煮时间为2.2小时,第二次煎煮水的重量为十味中药总重量的7倍,第二次煎煮时间为1.4小时,两次煎煮分别过滤,合并两次滤液;
(3)将合并的两次滤液真空浓缩成清膏,清膏在60℃下,相对密度为1.05g/cm3,加入凝胶赋形剂卡波姆,在均质机中制成凝胶,然后加入备用的蜂胶、溶菌酶、薄荷脑和大豆肽均质半小时,将配好的凝胶用自动凝胶灌装机灌装,得到凝胶。
对比例1
本对比例制备的凝胶与实施例3相同,不同之处,不添加蛇床子。
对比例2
本对比例制备的凝胶与实施例3相同,不同之处,不添加五倍子。
对比例3
本对比例制备的凝胶与实施例3相同,不同之处,不添加黄柏。
对比例4
本对比例制备的凝胶与实施例3相同,不同之处,不添加菟丝子。
试验例1
将实施例1-4和对比例1-4制备的中药生物制剂置于37℃恒温箱内3个月,保持相对湿度75%,进行抑菌性能测试,结果见表1。
表1
从实施例1-4和对比例1-4中可以看出,本发明制备的中药生物制剂具有较好的抑菌作用,通过本发明的蛇床子、五倍子、黄柏和菟丝子特定比例制备起到协同的作用,对大肠杆菌、白色念珠菌和金黄色葡萄球菌具有较好的抑制作用,不可缺少,缺少其中一种抑菌效果明显下降。
试验例2
将实施例3和对比例1-4制备的中药生物制剂进行对阴道粘膜刺激性试验
试验动物:新西兰家兔,雌性,20只。
实验方法:分别将实施例3和对比例1-4制备的中药生物制剂阴道给药家兔,插入家兔阴道约2-3cm,给药剂量为1.0g/只,连续给药10天,于最后一次给药24h后,处死动物,解剖取出阴道标本,纵向切开,肉眼观察粘膜有无充血、肿胀等现象,按照表2和表3进行阴道粘膜刺激反应评分及刺激强度评价,评价得到的分值求平均值,结果见表4。
表2
形态改变 | 反应评分 |
无改变或无明显改变 | 0 |
轻度充血,少量分泌物 | 1 |
中度充血,分泌物较多 | 2 |
重度淤血,水肿,分泌物很多,粘膜变性 | 3 |
表3
平均分值(X) | 评价 |
≤0.4 | 无刺激 |
0.4<X≤1.5 | 轻度刺激性 |
1.5<X≤2.5 | 中度刺激性 |
>2.5 | 重度刺激性 |
表4
样品 | 反应评分 |
实施例3 | 0.12 |
对比例1 | 1.89 |
对比例2 | 1.91 |
对比例3 | 2.34 |
对比例4 | 2.47 |
从表4可以看出,对比例1-4制备的中药生物制剂对阴道具有中度的刺激,说明缺少蛇床子、五倍子、黄柏和菟丝子其中的一种都会对阴道产生刺激。
本发明人也对其他实施例做了上述试验,结果基本一致,由于篇幅有限,不再一一列举。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种促进女性生殖健康的中药生物制剂,其特征在于,包括如下原料:苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄、蔓越莓、蜂胶、溶菌酶、薄荷脑和大豆肽。
2.根据权利要求1所述的促进女性生殖健康的中药生物制剂,其特征在于,按照重量份,包括如下原料:苦参16-20重量份、蛇床子16-20重量份、五倍子14-18重量份、芦荟10-16重量份、当归6-10重量份、黄柏4-8重量份、红花3-7重量份、菟丝子3-7重量份、玫瑰茄1-5重量份、蔓越莓1-5重量份、蜂胶1-3重量份、溶菌酶0.5-2.5重量份、薄荷脑0.2-0.24重量份和大豆肽0.03-0.07重量份。
3.根据权利要求2所述的促进女性生殖健康的中药生物制剂,其特征在于,按照重量份,包括如下原料:苦参18重量份、蛇床子18重量份、五倍子16重量份、芦荟13重量份、当归8重量份、黄柏6重量份、红花5重量份、菟丝子5重量份、玫瑰茄3重量份、蔓越莓3重量份、蜂胶2重量份、溶菌酶1.5重量份、薄荷脑0.22重量份和大豆肽0.05重量份。
4.根据权利要求1-3任意一项所述的促进女性生殖健康的中药生物制剂,其特征在于,所述的中药生物制剂的剂型为液体冲洗剂、片剂或凝胶。
5.一种权利要求3所述的促进女性生殖健康的中药生物制剂的制备方法,其特征在于,包括如下步骤:
(1)按照各原料的重量称取备用;
(2)将备用的苦参、蛇床子、五倍子、芦荟、当归、黄柏、红花、菟丝子、玫瑰茄和蔓越莓十味中药分别分两次加入蒸馏水煎煮两次,两次煎煮分别过滤,合并两次滤液;
(3)将合并的两次滤液真空浓缩成清膏,然后加入可接受的药用辅料,再加入备用的蜂胶、溶菌酶、薄荷脑和大豆肽均质,得到制剂。
6.根据权利要求5所述的促进女性生殖健康的中药生物制剂的制备方法,其特征在于,步骤(2)中第一次煎煮水的重量为十味中药总重量的6-10倍,第一次煎煮时间为1.5-2.5小时。
7.根据权利要求6所述的促进女性生殖健康的中药生物制剂的制备方法,其特征在于,步骤(2)中第一次煎煮水的重量为十味中药总重量的8倍,第一次煎煮时间为2小时。
8.根据权利要求5所述的促进女性生殖健康的中药生物制剂的制备方法,其特征在于,步骤(2)中第二次煎煮水的重量为十味中药总重量的4-8倍,第二次煎煮时间为1-2小时。
9.根据权利要求8所述的促进女性生殖健康的中药生物制剂的制备方法,其特征在于,步骤(2)中第二次煎煮水的重量为十味中药总重量的6倍,第二次煎煮时间为1.5小时。
10.根据权利要求8所述的促进女性生殖健康的中药生物制剂的制备方法,其特征在于,步骤(3)中浓缩的清膏在60℃下,相对密度为1.05g/cm3。
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111569054A (zh) * | 2020-06-09 | 2020-08-25 | 陕西丽仕生物科技有限公司 | 一种妇科抑菌凝胶及其制备方法 |
CN112263667A (zh) * | 2020-10-15 | 2021-01-26 | 李利发 | 作用于女性生殖道健康的中药生物制剂及其制备方法 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106938029A (zh) * | 2016-01-05 | 2017-07-11 | 郑凯峰 | 一种抑菌凝胶及其制备方法 |
CN109010526A (zh) * | 2018-08-23 | 2018-12-18 | 河北蕊雅生物科技有限公司 | 一种用于阴道黏膜抑菌养护清洁的中药凝胶组合物 |
CN109395054A (zh) * | 2019-01-04 | 2019-03-01 | 赵显梁 | 一种抑菌紧致凝胶及其制备方法 |
CN110214945A (zh) * | 2019-07-25 | 2019-09-10 | 南京圣诺生物科技实业有限公司 | 改善女性泌尿生殖系统健康的益生菌组合物及其制备方法 |
-
2019
- 2019-09-20 CN CN201910893065.6A patent/CN110478477A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106938029A (zh) * | 2016-01-05 | 2017-07-11 | 郑凯峰 | 一种抑菌凝胶及其制备方法 |
CN109010526A (zh) * | 2018-08-23 | 2018-12-18 | 河北蕊雅生物科技有限公司 | 一种用于阴道黏膜抑菌养护清洁的中药凝胶组合物 |
CN109395054A (zh) * | 2019-01-04 | 2019-03-01 | 赵显梁 | 一种抑菌紧致凝胶及其制备方法 |
CN110214945A (zh) * | 2019-07-25 | 2019-09-10 | 南京圣诺生物科技实业有限公司 | 改善女性泌尿生殖系统健康的益生菌组合物及其制备方法 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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CN111569054A (zh) * | 2020-06-09 | 2020-08-25 | 陕西丽仕生物科技有限公司 | 一种妇科抑菌凝胶及其制备方法 |
CN112263667A (zh) * | 2020-10-15 | 2021-01-26 | 李利发 | 作用于女性生殖道健康的中药生物制剂及其制备方法 |
CN112618702A (zh) * | 2020-12-29 | 2021-04-09 | 山东丽达生物科技集团有限公司 | 促进女性生殖道健康修复的中药生物制剂及其制备方法 |
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