CN115137795B - 一种减肥瘦身中药组合物及其制备方法 - Google Patents
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Abstract
本发明公开了一种减肥瘦身中药组合物，由以下重量份的原料药制成：茯苓10‑14份、肉桂6‑12份、葛根4‑8份、山楂6‑12份、薏苡仁12‑18份、芡实6‑12份、荷叶4‑8份、冬瓜皮6‑12份、橘皮6‑12份、甘草2‑4份，并公开了其制备方法，制备成袋泡茶，或者提取后制备成口服液或固体饮料，本发明具有补气健脾、燥湿化痰、利水的功效，针对痰湿型肥胖体质效果良好。
Description
技术领域
本发明涉及中药制剂技术领域，具体为一种减肥瘦身中药组合物及其制备方法。
背景技术
肥胖是由于体内脂肪的体积和(或)脂肪细胞数量的增加所导致的体重增加，或体脂占体重的百分比异常增高，表现为全身或人体某些局部过多的脂肪沉积。单纯性肥胖是指仅由于摄入热量高于消耗热量引起的脂肪蓄积而不患有相关内分泌代谢性疾病以及其他可能引起肥胖的特殊疾病或服用相关药物引起的肥胖，在患有肥胖症的所有人群中，单纯性肥胖者占据了绝大部分比例。
中医认为肥胖属本虚标实之证，与饮食、年龄、先天禀赋、外部环境及缺乏运动等因素相关。《内经》中所记载的“脂人”“膏人”“肉人”“肥贵人”“肥美之人”等均属肥胖范畴。肥胖病的治疗都是辨证论治，临床上常见的证型有：胃热湿阻型、脾虚湿阻型、肝郁气滞型、脾肾两虚型、阴虚内热型。《丹溪心法》载：“肥人气虚生寒，寒生湿，湿生痰……故肥人多寒湿。”可见痰湿是肥胖形成的最主要原因。“太阳司天，湿气变物，水饮内蓄，中满不食”，易造成痰湿，故中满亦为肥胖的病因。痰湿体质是以脾胃功能减退，痰湿停聚、重浊黏腻为主要特征的体质状态。痰湿质者体内痰湿雍盛易阻滞气机，影响脾胃枢降，导致运化失职，水谷精微不化，故发肥胖。脾虚湿盛型肥胖的典型症状：腹胀纳少，食后胀甚，肢体倦怠，神疲乏力，少气懒言，形体消瘦，或肥胖浮肿，舌苔淡白。目前大部分减肥产品使用泻药，一般都会有副作用，常见的是胃肠道不适，出现恶心呕吐、排气增多、大便紧急感、脂肪泄，情况严重的甚至会出现大便失禁的情况。通过药物减肥会形成依赖性，一旦脱离药物体重立即反弹，为此，提出一种减肥瘦身中药组合物及其制备方法，适用于痰湿型肥胖体质。
发明内容
本发明的目的在于提供一种减肥瘦身中药组合物及其制备方法。
为实现上述目的，本发明提供如下技术方案：一种减肥瘦身中药组合物，所述的减肥瘦身中药组合物由以下重量份的原料药制成：茯苓10-14份、肉桂6-12份、葛根4-8份、山楂6-12份、薏苡仁12-18份、芡实6-12份、荷叶4-8份、冬瓜皮6-12份、橘皮6-12份、甘草2-4份。
所述的减肥瘦身中药组合物，茯苓10份、肉桂6份、葛根4份、山楂12份、薏苡仁12份、芡实12份、荷叶4份、冬瓜皮12份、橘皮6份、甘草4份。
所述的减肥瘦身中药组合物，茯苓14份、肉桂6份、葛根8份、山楂6份、薏苡仁18份、芡实6份、荷叶8份、冬瓜皮6份、橘皮12份、甘草2份。
所述的减肥瘦身中药组合物，茯苓12份、肉桂6份、葛根6份、山楂9份、薏苡仁15份、芡实9份、荷叶6份、冬瓜皮9份、橘皮9份、甘草3份。
所述的减肥瘦身中药组合物，制备方法为：取茯苓、肉桂、葛根、山楂、薏苡仁、芡实、荷叶、冬瓜皮、橘皮、甘草，烘干，粉碎成粗粉，灌装于无纺布袋中，每袋15克。
所述的减肥瘦身中药组合物，制备方法为：(1)取橘皮，进行水蒸气蒸馏，提取橘皮挥发油，备用；(2)取橘皮水蒸气蒸馏提取后的水溶液过滤，得橘皮蒸馏后的水溶液，减压浓缩，醇沉，得上清液，为橘皮水蒸气蒸馏后的水提醇沉液，备用；(3)将步骤(2)所得橘皮水蒸气蒸馏提取后的药渣，与其余药材混合，加药材重量10倍量的水，煎煮二次，每次2小时，滤过，得水煎液，浓缩，醇沉，得上清液，为水提醇沉液；(4)将步骤(3)所得水提醇沉液、步骤(2)所得橘皮蒸馏后的水提醇沉液，合并，加入步骤(1)所得橘皮挥发油，制备成口服液。
所述的减肥瘦身中药组合物，制备方法为：(1)取橘皮，进行水蒸气蒸馏，提取橘皮挥发油，备用；(2)取橘皮水蒸气蒸馏提取后的水溶液，滤过，得橘皮蒸馏后的水溶液，减压浓缩，醇沉，得上清液，为橘皮水蒸气蒸馏后的水提醇沉液，备用；(3)将步骤(2)所得橘皮水蒸气蒸馏提取后的药渣，与其余药材混合，加药材重量10倍量的水，煎煮二次，每次2小时，滤过，得水煎液，浓缩，醇沉，得上清液，为水提醇沉液；(4)将步骤(3)所得水提醇沉液、步骤(2)所得橘皮蒸馏后的水提醇沉液，合并，喷雾干燥，添加辅料，加入步骤(1)所得橘皮挥发油，制备成固体饮料。
所述的减肥瘦身中药组合物，葛根为野葛。
所述的减肥瘦身中药组合物，两次醇沉条件均为：加入95％乙醇，搅匀，使药液含醇量达到70％，静置24小时。
所述的减肥瘦身中药组合物在制备降血脂和减肥保健品中的应用，肥胖的证型为痰湿型肥胖体质。
茯苓(学名：Wolfiporia cocos(F.A.Wolf)Ryvarden&Gilb.)是多孔菌科、茯苓属真菌。菌丝体呈白色绒毛状，幼时白色，老时淡褐色。气生菌丝短而直立，更多的是纵横交错，密集贯穿于基质中，菌核由外皮膜、内皮膜、多糖粒形成层及多糖粒积累层构成。菌核是茯苓的休眠器官，又是贮藏器官，菌核发育到一定阶段，向上膨大增长，露出土面，菌丝在菌核表面生长扩大，顶端菌丝不断向外生长，发育成子实体。子实体大小不一，平卧于菌核表面或菌丝体表面，初时白色，后淡褐色，孢子无包透明，表面光滑，主要分布于中国、美洲、大洋洲和日本及东南亚的一些国家。中国人工栽培产量大的地区有湖南、湖北、贵州、云南、广西、福建、安徽等省，区。茯苓多生于松属植物根上，适宜中海拔、气候凉爽、干燥、砂质土壤、10-35°坡地。茯苓是中国传统中药。茯苓味甘、淡、性平无毒，入心、脾、肺，肾四经，具有渗湿利水，益脾胃保肾，安神生津等功效。
葛根为豆科植物野葛(Pueraria lobate(Willd.)Ohwi)的干燥根，习称野葛。秋、冬二季采挖，趁鲜切成厚片或小块；干燥。甘、辛，凉。有解肌退热，透疹，生津止渴，升阳止泻之功。常用于表证发热，项背强痛，麻疹不透，热病口渴，阴虚消渴，热泻热痢，脾虚泄泻。
山楂为蔷薇科植物山里红Crataegus pin,natiida Bge.var.majorN.E.Br.或山楂Crataegus pin.nati fida Bge.的干燥成熟果实。秋季果实成熟时采收，切片，干燥。性味酸、甘，微温。归脾、胃、肝经。消食健胃，行气散瘀，化浊降脂。用于肉食积滞，胃脘胀满，泻痢腹痛，瘀血经闭，产后瘀阻，心腹刺痛，胸痹心痛，疝气疼痛，高脂血症。焦山楂消食导滞作用增强。用于肉食积滞，泻痢不爽。
薏苡仁为禾本科植物薏苡Coix lacryma-jobi L.var.mayuen(Roman.)Stapf的干燥成熟种仁。秋季果实成熟时采割植株，晒干，打下果实，再晒干，除去外壳、黄褐色种皮和杂质，收集种仁。性味甘、淡，性凉。归脾、胃、肺经。有利水渗湿，健脾止泻，除痹，排脓，解毒散结的作用。用于水肿，脚气，小便不利，脾虚泄泻，湿痹拘挛，肺痈，肠痈；赘疣，癌肿。
芡实，为睡莲科植物芡Euryale ferox Salisb.的干燥成熟种仁。分布于从黑龙江至云南、广东等地。具有益肾固精，补脾止泻，除湿止带之功效。常用于遗精滑精，遗尿尿频，脾虚久泻，白浊，带下。
橘皮为芸香科植物橘Citrus reticulata Blanco及其栽培变种的干燥成熟果皮。药材分为“陈皮”和“广陈皮”。采摘成熟果实，剥取果皮，晒干或低温干燥。性味苦、辛，性温。归肺、脾经。理气健脾，燥湿化痰。用于脘腹胀满，食少吐泻，咳嗽痰多。
荷叶为莲科莲属多年生草本挺水植物莲荷(Nelumbo nucifera)的叶。荷花一般长到150厘米高，横向扩展到3米。荷叶最大可达直径60厘米，莲花最大直径可达20厘米。荷花有许多不同的栽培品种，花色从雪白、黄色到淡红色及深黄色和深红色，其外还有分洒锦等等花色。广布于南北各地。主要有清热解暑，升发清阳，散瘀止血的功效。
肉桂为樟科植物肉桂Cinnamomum cassia Presl的干燥树皮。多于秋季剥取，阴干。味辛、甘，性大热。归肾、脾、心、肝经。有补火助阳，引火归元，散寒止痛，温通经脉的功效。用于阳痿宫冷，腰膝冷痛，肾虚作喘，虚阳上浮，眩晕目赤，心腹冷痛，虚寒吐泻，寒疝腹痛，痛经经闭。
冬瓜皮为葫芦科植物冬瓜Benincasa his pida(Thunb.)Cogn.的干燥外层果皮。食用冬瓜时，洗净，削取外层果皮，晒干。味甘，性凉。归脾、小肠经。利尿消肿。用于水肿胀满，小便不利，暑热口渴，小便短赤。
甘草(学名：Glycyrrhiza uralensis Fisch.)是豆科、甘草属植物。多年生草本，根与根状茎粗状，直径1-3厘米。具甜味。茎直立，多分枝，高30-120厘米。叶长5-20厘米，托叶三角状披针形。总状花序腋生，具多数花，总花梗短于叶，密生褐色的鳞片状腺点和短柔毛；苞片长圆状披针形，长3-4毫米；花萼钟状，长7-14毫米，密被黄色腺点及短柔毛；花冠紫色、白色或黄色；子房密被刺毛状腺体。荚果弯曲呈镰刀状或呈环状。种子3-11，暗绿色，圆形或肾形，长约3毫米。花期6-8月，果期7-10月。分布于中国、阿富汗、哈萨克斯坦、吉尔吉斯斯坦、巴基斯坦、塔吉克斯坦、蒙古及俄罗斯西伯利亚地区；在中国分布于东北、华北、西北各省区及山东。常生于干旱沙地、河岸砂质地、山坡草地及盐渍化土壤中。根和根状茎供药用。甘草除了补脾益气、润肺止咳、清热解毒和调和诸药等功效外，还用于咽喉肿痛、脾胃虚寒、消化性溃疡、中毒等症状。因此甘草有“十药九草”的称呼。
与现有技术相比，本发明的有益效果是：
1、《灵枢2阴阳二十五人》所述土型之人亦属于痰湿体质，土型人属土，土气阴湿，湿性黏腻，阻碍脾胃功能而致痰湿蕴积而胖。脾虚湿盛型肥胖的典型症状：腹胀纳少，食后胀甚，肢体倦怠，神疲乏力，少气懒言，形体消瘦，或肥胖浮肿，舌苔淡白。痰湿体质是以脾胃功能减退，痰湿停聚、重浊黏腻为主要特征的体质状态。痰湿质者体内痰湿雍盛易阻滞气机，影响脾胃枢降，导致运化失职，水谷精微不化，故发肥胖。肥胖病多种病因导致了人体阴阳失调，脏腑功能失司，阳气虚损，痰湿内生，如病程日久，肾气亏虚，脾失运化、气化不利。病久入肾，肥胖的实质属于本虚标实，本虚则属脾肾气虚，标实责之肝气瘀滞、痰浊内停，血瘀等。另外胆在肥胖的发病中居于十分重要的地位。胆“藏泻并兼”其主要功能是贮藏排泄胆汁而胆汁中含有助消化、助吸收和助排泄的成分，既能上助脾胃以转运、消化，又能下助肠腑以吸收、排泄，因此胆在饮食物的新陈代谢过程中占有举足轻重的地位。根据以上分析，因此本发明通过如下几个方面改善肥胖，其一，补气益肾、疏肝利胆理气，肾气乃是人体的精血所在,气生万物，固肾气足，则万物生；其二，健脾利湿，脾胃为后天之本，气血生化之源；其三，由于肝气郁结，血行不畅，瘀血内结，需活血化瘀，理气化痰。全方茯苓益脾胃保肾，安神生津，肉桂补火助阳、温通经脉；葛根入肝胆经升发阳气，疏肝解郁,前两者补肾助阳,后者疏肝,共为君药,山楂消食健脾、行气消瘀，薏苡仁利水渗湿，健脾止泻，芡实益肾固精，补脾止泻，前者助脾胃，配合薏苡仁和芡实，健脾利湿，共为臣药，荷叶升发清阳，散瘀止血、润肠通便，冬瓜皮利尿消肿，橘皮理气调中，燥湿化痰，三者活血化瘀，理气化痰为佐药，甘草调和诸药为使药，诸药配伍，相得益彰，能治疗病程久，痰湿型肥胖。
2、本发明采用袋泡茶和提取物两种剂型，便于携带，方便患者选择,特别是提取物做成茶固体饮料，有效成分含量高。
具体实施方式
基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1：取茯苓10g、肉桂6g、葛根4g、山楂12g、薏苡仁12g、芡实12g、荷叶4g、冬瓜皮12g、橘皮6g、甘草4g，烘干，粉碎成粗粉，灌装于无纺布袋中，即得袋泡茶，每袋15克。
实施例2：取茯苓14g、肉桂6g、葛根8g、山楂6g、薏苡仁18g、芡实6g、荷叶8g、冬瓜皮6g、橘皮12g、甘草2g，烘干，粉碎成粗粉，灌装于无纺布袋中，即得袋泡茶，每袋15克。
实施例3：取茯苓12g、肉桂6g、葛根6g、山楂9g、薏苡仁15g、芡实9g、荷叶6g、冬瓜皮9g、橘皮9g、甘草3g，烘干，粉碎成粗粉，灌装于无纺布袋中，即得袋泡茶，每袋15克。
实施例4：取茯苓12g、肉桂6g、葛根6g、山楂9g、薏苡仁15g、芡实9g、荷叶6g、冬瓜皮9g、橘皮9g、甘草3g，制备方法为：(1)取橘皮，进行水蒸气蒸馏，提取橘皮挥发油，备用；(2)取橘皮水蒸气蒸馏提取后的水溶液过滤，得橘皮蒸馏后的水溶液，减压浓缩，醇沉，得上清液，为橘皮水蒸气蒸馏后的水提醇沉液，备用；(3)将步骤(2)所得橘皮水蒸气蒸馏提取后的药渣，与其余药材混合，加药材重量10倍量的水，煎煮二次，每次2小时，滤过，得水煎液，浓缩，醇沉，得上清液，为水提醇沉液；(4)将步骤(3)所得水提醇沉液、步骤(2)所得橘皮蒸馏后的水提醇沉液，合并，喷雾干燥，加入步骤(1)所得橘皮挥发油，添加辅料，制备成固体饮料。两次醇沉条件均为：加入95％乙醇，搅匀，使药液含醇量达到70％，静置24小时。
实施例5：取茯苓12g、肉桂6g、葛根6g、山楂9g、薏苡仁15g、芡实9g、荷叶6g、冬瓜皮9g、橘皮9g、甘草3g，制备方法为：(1)取橘皮，进行水蒸气蒸馏，提取橘皮挥发油，备用；(2)取橘皮水蒸气蒸馏提取后的水溶液过滤，得橘皮蒸馏后的水溶液，减压浓缩，醇沉，得上清液，为橘皮水蒸气蒸馏后的水提醇沉液，备用；(3)将步骤(2)所得橘皮水蒸气蒸馏提取后的药渣，与其余药材混合，加药材重量10倍量的水，煎煮二次，每次2小时，滤过，得水煎液，浓缩，醇沉，得上清液，为水提醇沉液；(4)将步骤(3)所得水提醇沉液、步骤(2)所得橘皮蒸馏后的水提醇沉液，合并，加入步骤(1)所得橘皮挥发油，制备成口服液。两次醇沉条件均为：加入95％乙醇，搅匀，使药液含醇量达到70％，静置24小时。
实施例6：取茯苓14g、肉桂6g、葛根8g、山楂6g、薏苡仁18g、芡实6g、荷叶8g、冬瓜皮6g、橘皮12g、甘草2g，制备方法为：(1)取橘皮，进行水蒸气蒸馏，提取橘皮挥发油，备用；(2)取橘皮水蒸气蒸馏提取后的水溶液过滤，得橘皮蒸馏后的水溶液，加热浓缩，醇沉，得上清液，为橘皮水蒸气蒸馏后的水提醇沉液，备用；(3)将步骤(2)所得橘皮水蒸气蒸馏提取后的药渣，与其余药材混合，加药材重量10倍量的水，煎煮二次，每次2小时，滤过，得水煎液，浓缩，醇沉，得上清液，为水提醇沉液；(4)将步骤(3)所得水提醇沉液、步骤(2)所得橘皮蒸馏后的水提醇沉液，合并，喷雾干燥，加入步骤(1)所得橘皮挥发油，添加辅料，制备成固体饮料。两次醇沉条件均为：加入95％乙醇，搅匀，使药液含醇量达到70％，静置24小时。所述的减肥瘦身中药组合物，葛根为野葛。
实施例7：本发明减肥瘦身中药组合物降血脂作用
将80只雌雄各半的SD大鼠平均分为8组，每组10只；分别为正常组，高脂对照组、实验组1～6。正常组每天喂养普通饲料，高脂对照组以及实验组1～5每天喂养高脂饲料(高脂饲料配方：普通饲料78.8％，胆固醇1％，牛胆盐0.2％，蛋黄粉10％，猪油10％；普通饲料配方：玉米73.5％，麦麸20％，鱼粉5％，谷粉1％，食盐0.5％)，各组SD大鼠都自由饮水。其中，实验组1～6在每天的喂养的高脂饲料中按5mg/kg的量加入实施例1～6制备得到的具有降血脂作用的袋泡茶或固体饮料。连续喂养30天后处死SD大鼠，经腹腔静脉采血后测定各组SD大鼠血清总胆固醇TC以及甘油三酯TG的含量；试验结果见表1。
表1.降血脂试验结果
| 分组 | TC含量(mmol/L) | TG含量(mmol/L) |
| 正常组 | 1.64±0.45 | 1.39±0.28 |
| 高脂对照组 | <![CDATA[8.23±2.14<sup>##</sup>]]> | <![CDATA[3.17±1.85<sup>##</sup>]]> |
| 实施例1组 | <![CDATA[4.67±0.75<sup>*</sup>]]> | <![CDATA[2.98±0.57<sup>*</sup>]]> |
| 实施例2组 | <![CDATA[3.97±0.81<sup>*</sup>]]> | <![CDATA[3.53±0.60<sup>*</sup>]]> |
| 实施例3组 | <![CDATA[4.56±0.73<sup>*</sup>]]> | <![CDATA[2.97±0.56<sup>*</sup>]]> |
| 实施例4组 | <![CDATA[3.49±0.54<sup>**</sup>]]> | <![CDATA[1.89±0.45<sup>**</sup>]]> |
| 实施例5组 | <![CDATA[3.87±0.76<sup>**</sup>]]> | <![CDATA[1.91±0.62<sup>**</sup>]]> |
| 实施例6组 | <![CDATA[3.47±0.57<sup>**</sup>]]> | <![CDATA[1.70±0.53<sup>**</sup>]]> |
与正常组比较：#P<0.05，##P<0.01；与对照组比较：*P<0.05，**P<0.01
由表1实验数据可以看出，喂养了实施例1～6制备得到的具有降血脂作用的袋泡茶或茶固体饮料的SD大鼠，其血清总胆固醇TC以及甘油三酯TG的含量明显低于高脂对照组的SD大鼠。这说明本发明所述的袋泡茶或茶固体饮料具有优异的降血脂作用，而且茶固体饮料效果好于袋泡茶，说明经提取后有效成分含量更高。
实施例8：本发明减肥瘦身中药组合物功能实验研究
一般资料：选取学校门诊就诊的单纯性肥胖患者共60例，男26例，女34例；年龄16～68岁；病程8～20年，进行给药前后对比。
纳入标准：①符合单纯性肥胖的西医学诊断标准。诊断需符合以下两项临床指标：a.根据病史、症状、查体、辅助检查排除继发性肥胖；b.实测体重超过标准体重的20％以上，脂肪百分比(F％)≥30％，体重指数(BMI)≥25，符合三项或两项者即可。中医诊断为：脾虚湿盛型肥胖，典型症状：腹胀纳少，食后胀甚，肢体倦怠，神疲乏力，少气懒言，形体消瘦，或肥胖浮肿，舌苔淡白。
治疗过程：使用本发明实施例4制备的茶固体饮料，每日3次，每次2袋，每袋含中药15克，服用1个月，观察两组治疗前后的体重、体重指数(BMI)、腰围、臀围、腰臀比(WHR)、血清总胆固醇(TC)、甘油三酯(TG)等指标。
表2.治疗前后体重、BMI、腰围、臀围、WHR、TC、TG比较(x±s)
| 观察指标 | 治疗前 | 治疗后 |
| 体重(Kg) | 75.45±6.79 | <![CDATA[67.82±7.13<sup>*</sup>]]> |
| <![CDATA[BMI(Kg/m<sup>2</sup>)]]> | 34.65±4.82 | <![CDATA[29.36±3.05<sup>*</sup>]]> |
| 腰围(cm) | 92.54±6.35 | 86.90±5.23 |
| 臀围(cm) | 108.69±9.25 | 102.49±7.53 |
| WHR(％) | 85.14±3.41 | 84.79±4.18 |
| TC(mmol/L) | 5.67±1.58 | <![CDATA[3.97±1.12<sup>*</sup>]]> |
| TG(mmol/L) | 2.37±0.92 | <![CDATA[1.76±0.71<sup>**</sup>]]> |
与治疗前比较：*P<0.05，**P<0.01
结果：治疗前后体重、BMI、TC、TG比较，体重、BMI、腰围、臀围、WHR、TC、TG等指标与治疗前比较均降低(P＜0.05)，腰围、臀围、WHR与治疗前比较均降低，说明本发明治疗病程久，痰湿型肥胖体质效果良好。
尽管本发明的描述是通过特定实施例进行的，但本领域技术人员应当理解的是，本发明也可以涵盖于如文中所说的本发明的界限之内的其他实施方式。
Claims (9)
1. 一种具有减肥作用的中药组合物，其特征在于，由以下重量份的原料药制成：茯苓10-14份、肉桂6-12份、葛根4-8份、山楂 6-12份、薏苡仁12-18份、芡实6-12份、荷叶4-8份、冬瓜皮6-12份、橘皮6-12份、甘草2-4份。
2. 根据权利要求1所述具有减肥作用的中药组合物，其特征在于，由以下重量份的原料药制成：茯苓10份、肉桂6份、葛根4份、山楂 12份、薏苡仁12份、芡实12份、荷叶4份、冬瓜皮12份、橘皮6份、甘草4份。
3. 根据权利要求1所述具有减肥作用的中药组合物，其特征在于，由以下重量份的原料药制成：茯苓14份、肉桂6份、葛根8份、山楂 6份、薏苡仁18份、芡实6份、荷叶8份、冬瓜皮6份、橘皮12份、甘草2份。
4. 根据权利要求1所述具有减肥作用的中药组合物，其特征在于，由以下重量份的原料药制成：茯苓12份、肉桂6份、葛根6份、山楂 9份、薏苡仁15份、芡实9份、荷叶6份、冬瓜皮9份、橘皮9份、甘草3份。
5.根据权利要求1-4任一项所述具有减肥作用的中药组合物，其特征在于，制备方法为：取茯苓、肉桂、葛根、山楂、薏苡仁、芡实、荷叶、冬瓜皮、橘皮、甘草，烘干，粉碎成粗粉，灌装于无纺布袋中，每袋15克。
6.根据权利要求1-4任一项所述具有减肥作用的中药组合物，其特征在于，制备方法为：(1)取橘皮，进行水蒸气蒸馏，提取橘皮挥发油，备用；(2)取橘皮水蒸气蒸馏提取后的水溶液，滤过，得橘皮蒸馏后的水溶液，减压浓缩，醇沉，得上清液，为橘皮水蒸气蒸馏后的水提醇沉液，备用；(3)将步骤(2)所得橘皮水蒸气蒸馏提取后的药渣，与其余药材混合，加药材重量10倍量的水，煎煮二次，每次2小时，滤过，得水煎液，浓缩，醇沉，得上清液，为水提醇沉液；(4)将步骤(3)所得水提醇沉液、步骤(2)所得橘皮蒸馏后的水提醇沉液，合并，加入步骤（1）所得橘皮挥发油，制备成口服液。
7.根据权利要求1-4任一项所述具有减肥作用的中药组合物，其特征在于，制备方法为：(1)取橘皮，进行水蒸气蒸馏，提取橘皮挥发油，备用；(2)取橘皮水蒸气蒸馏提取后的水溶液，滤过，得橘皮蒸馏后的水溶液，减压浓缩，醇沉，得上清液，为橘皮水蒸气蒸馏后的水提醇沉液，备用；(3)将步骤(2)所得橘皮水蒸气蒸馏提取后的药渣，与其余药材混合，加药材重量10倍量的水，煎煮二次，每次2小时，滤过，得水煎液，浓缩，醇沉，得上清液，为水提醇沉液；(4)将步骤(3)所得水提醇沉液、步骤(2)所得橘皮蒸馏后的水提醇沉液，合并，喷雾干燥，添加辅料，加入步骤（1）所得橘皮挥发油，制备成固体饮料。
8.根据权利要求6或7所述具有减肥作用的中药组合物，其特征在于，两次醇沉条件均为：加入95％乙醇，搅匀，使药液含醇量达到70％，静置24小时。
9.根据权利要求1或2所述具有减肥作用的中药组合物在制备减肥保健品中的应用。
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| US8168239B1 (en) * | 2011-03-25 | 2012-05-01 | Se Kyu Im | Method for the production of diet food with medicinal herbs |
| CN102697861A (zh) * | 2012-06-07 | 2012-10-03 | 周彦廷 | 一种减肥保健组合物 |
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