WO2019015091A1 - 一种用于治疗急性肠胃炎的中药 - Google Patents

一种用于治疗急性肠胃炎的中药 Download PDF

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Publication number
WO2019015091A1
WO2019015091A1 PCT/CN2017/103316 CN2017103316W WO2019015091A1 WO 2019015091 A1 WO2019015091 A1 WO 2019015091A1 CN 2017103316 W CN2017103316 W CN 2017103316W WO 2019015091 A1 WO2019015091 A1 WO 2019015091A1
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parts
ginger
chinese medicine
traditional chinese
acute gastroenteritis
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PCT/CN2017/103316
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English (en)
French (fr)
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田丽华
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淄博夸克医药技术有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/535—Perilla (beefsteak plant)
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    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
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    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Definitions

  • the invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating acute gastroenteritis.
  • Acute gastroenteritis is an acute inflammation of the gastrointestinal mucosa.
  • blood in the stool, hematemesis, etc. poses a great threat to the safety of patients.
  • the disease is common in summer and autumn, and it occurs mostly due to improper diet, overeating; or eating cold and rot, turbid and unclean food.
  • There are many clinical treatment methods for acute gastroenteritis but the ideal therapeutic effect is not achieved.
  • the toxic and side effects produced by traditional Chinese medicine treatment are less, and the clinical treatment effect obtained is more significant.
  • Gastroenteritis can be caused by spleen and stomach damage, spleen and stomach damage, lifting and losing the spleen, clear and turbid, and the disease; or eating rot and spoilage, eating cold, overeating, can directly damage the spleen and stomach , leading to clear air does not rise, turbidity does not drop, vomiting and diarrhea, and cause disease; or the body spleen and stomach weakness, cooked rot, water and valley is weak, that is, the water valley is stagnant, clear and turbid, regardless of the disease.
  • Patchouli [alias] musk, vanilla. [Source] This product is the dry aerial part of the musk plant of the Labiatae family. According to the different places of origin, it is divided into the brand of patchouli and Hainan patchouli. When the leaves are flourishing, the harvest is cut, and the sun is boring at night, and it is repeated until dry. [Sexual taste] Xin, lukewarm. [Return] to the spleen, stomach, lung. [Indications] Aroma and turbidity, appetizing and vomiting, and release of heat. For wet turbidity, vomiting, sputum, heat and dampness, chest tightness, uncomfortable, cold and dampness, abdominal pain, vomiting and diarrhea, nasal headache. [Usage and dosage] Oral: Jiantang, 3 ⁇ 10g. [Note] The yin deficiency is forbidden. [Excerpt] "Chinese Materia Medica”.
  • Perilla leaf [alias] Su Ye. [Source] This product is a dry leaf (or twig) of the genus Perilla. Harvested in summer when the foliage is flourishing, removing impurities and drying. [Sexual taste] Xin, warm. [Return] to the lungs, spleen. ⁇ Functions and Indications ⁇ Solve the cold, qi and stomach. For cold, cold, cough, vomiting, pregnancy Vomiting, fish and crab poisoning. [Usage and dosage] Oral: Jiantang, 5 ⁇ 9g. [Note] The disease is yin deficiency, because of cold or fever or aversion to cold and headache, careful to vote, to be appropriate to compensate for the disease. It is not appropriate for people to rise or swear. [Excerpt] "Chinese Materia Medica”.
  • Atractylodes [alias] in surgery, winter surgery, Zhejiang surgery, seed surgery. [Source] This product is the dried rhizome of Atractylodes macrocephala. In the winter, when the lower leaves are yellow and the upper leaves become brittle, they are excavated, removed from the sediment, dried or dried, and then the roots are removed. [Sexual taste] bitter, sweet, warm. [Return to the spleen] stomach, stomach. [Indications] spleen and qi, dampness and water, antiperspirant, and fetus. For spleen deficiency, less bloating, diarrhea, sputum, edema, edema, spontaneous sweating, fetal movement.
  • Pinellia [alias] three leaves and half summer, three leaves old, three steps, Ma Yu fruit, swallow tail, geography, water jade. [Source] This product is a dry tuber of Pinellia ternata. Excavate in summer and autumn, wash, remove the skin and fibrous roots, and dry. [Sexual taste] Xin, warm; poisonous. [Return] to the spleen, stomach, lung. ⁇ Functions and Indications ⁇ Dry and phlegm, reduce vomiting, eliminate phlegm and disperse.
  • This product is dried dry skin, root bark and branch bark of Magnolia plant Magnolia or Magnolia officinalis. Stripped from April to June, the root bark and branches are directly dried; the dried skin is slightly boiled in boiling water, and the dampness is piled up. When it is "sweating” until the inner surface turns purple brown or brown, it is steamed and taken out. It is cylindrical and dry. [Sexual taste] bitter, spicy, warm. [Return] to the spleen, stomach, lungs, large intestine. ⁇ Functions and Indications ⁇ Dry and dry, eliminate the gas.
  • Licorice This product is the dry root of legume licorice, licorice licorice, and licorice. Excavation in spring and autumn, removing the roots and drying.
  • Gan, Ping. [Return to the heart] heart, lung, spleen, stomach. ⁇ Indications ⁇ Invigorating the spleen and replenishing qi, clearing away heat and detoxifying, relieving cough, relieving pain, and reconciling various medicines.
  • Platycodon grandiflorum [alias] bag flower, bell flower, cap flower, white medicine, stem grass. [Source] Chinese medicinal platycodon is the root of perennial herbaceous platycodon grandiflorum. [Sexual taste] bitter, Xin, flat, slightly cold. [Return to the classics] to the lungs. [Indications] Xuanfei, phlegm, pharynx, drainage, five internal organs, qi and blood, make up five labor, raise gas. More cough, sore throat, lungs and pus, chest full of hypochondriac pain, dysentery and abdominal pain, mouth sores, red eyes and swelling, urinary sputum closure.
  • Ginger [alias] ginger. [Source] This product is the fresh rhizome of gingeraceae ginger. Excavation in the autumn and winter seasons to remove the roots and sediment. [Sexual taste] Xin, lukewarm. [Return] to the lungs, spleen, stomach. ⁇ Functions and Indications ⁇ Solve the cold, stop the vomiting, relieve phlegm and relieve cough. For cold, cold, stomach vomiting, cold and cough. [Usage and dosage] Oral: Jiantang, 3 ⁇ 9g. [Note] It takes a long time to eat ginger and accumulate heat. People who eats sick and eats more wine and has a quick hair. People with acne eat more meat and have bad meat. [Excerpt] "Chinese Materia Medica”.
  • Big belly skin [alias] betel nut, large belly hair, mane, betel nut, big belly.
  • This product is the dried peel of the palm plant betel nut. The immature fruit is harvested from winter to spring, dried after cooking, two slits are longitudinally cut, and the peel is peeled off, which is called “big belly skin”; mature fruit is harvested from late spring to early autumn, dried after cooking. Peel the peel, loosen it, dry it, and call it "big belly hair.”
  • Jujube [alias] [source] This product is a dry mature fruit of the jujube plant. When the autumn fruit is ripe, it is harvested and dried. Its roots and bark are also used as medicine and can be taken at any time. [Sexual taste] sweet, warm. [Return to the spleen] stomach, stomach. [Indications] Buzhong Yiqi, nourishing blood and soothe the nerves. For spleen deficiency, less food, fatigue, and impotence. Anti-inflammatory, stop bleeding, stop diarrhea. For bronchitis, enteritis, dysentery, uterine bleeding; external treatment of traumatic bleeding. Qi, blood, and menstruation. For irregular menstruation, red collapse, vaginal discharge.
  • the invention aims to provide a traditional Chinese medicine for treating acute gastroenteritis, and achieve the purpose of safely and effectively curing acute gastroenteritis by selecting an appropriate medicinal material and its ratio.
  • the invention relates to a traditional Chinese medicine for treating acute gastroenteritis, which is prepared by the following raw materials of weight ratio: 10 parts of patchouli, 9 parts of white peony, 9 parts of perilla leaves, and atractylodes (fried) 12 Serving, 9 parts of Pinellia (system), 9 parts of dried tangerine peel, 15 parts of medlar, 9 parts of Magnolia (made of ginger), 10 parts of licorice, 10 parts of platycodon, 5 parts of ginger, 9 parts of large belly, and 15 parts of jujube.
  • 10 parts of patchouli 9 parts of white peony, 9 parts of perilla leaves, and atractylodes (fried) 12 Serving, 9 parts of Pinellia (system), 9 parts of dried tangerine peel, 15 parts of medlar, 9 parts of Magnolia (made of ginger), 10 parts of licorice, 10 parts of platycodon, 5 parts of ginger, 9 parts of large belly, and 15 parts of jujube.
  • Inventors collected a total of 90 outpatients and hospitalized patients with acute gastroenteritis from October 2012 to October 2013. They were randomly divided into treatment group of 45 cases and control group of 45 cases.
  • the treatment group consisted of 21 males and 24 females with an average age of 43.1.
  • the age of the control group was 19 males and 26 females with an average age of 50.6 years. There were no significant differences in gender, age and duration of disease between the two groups, which were comparable.
  • the treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day.
  • the course of treatment is 3 days.
  • the control group received oral erythromycin or oral glucose oral solution (according to the instructions) for 3 days.
  • Clinical control The number of bowel movements per patient after treatment is between 1 and 2 times, and it is normal to pass the test of the test indicators;
  • Invalid The number of times the patient has been treated for bowel movements, the traits of stool, and the detection of test indicators have not improved or even deteriorated.
  • the medicine prepared by the invention can safely and effectively treat acute gastroenteritis, and has the promotion value.

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Abstract

一种用于治疗急性肠胃炎的中药，它是由以下重量配比的原料药材制备而成：广藿香10份、白芷9份、紫苏叶9份、白术(炒)12份、半夏(制)9份、陈皮9份、茯苓15份、厚朴(姜制)9份、甘草10份、桔梗10份、生姜5份、大腹皮9份、大枣15份。

Description

一种用于治疗急性肠胃炎的中药 技术领域
本发明涉及一种中药，具体涉及一种用于治疗急性肠胃炎的中药。
背景技术
急性肠胃炎是胃肠粘膜的急性炎症，现便血、呕血等，对患者的生命安全造成了极大威胁。本病常见于夏秋季，其发生多由于饮食不当，暴饮暴食；或食入生冷腐馊、秽浊不洁的食品。急性肠胃炎的临床治疗方法较多，但是达不到理想的治疗效果，中药治疗产生的毒副作用少，取得的临床治疗效果较为显著。肠胃炎可由人体外感暑湿、寒邪之秽气，使脾胃受损，升降失司，清浊相干，而发病；或进食腐馊变质之物、恣食生冷、暴饮暴食，都可直接损伤脾胃，导致清气不升，浊气不降，吐泻交作，而致病；或素体脾胃虚弱，熟腐运化水谷不力，即水谷停滞、清浊不分，都可发为本病。
本发明所涉及药材研究现状如下：
广藿香【别名】藿香、排香草。【来源】本品为唇形科植物广藿香的干燥地上部分。按产地不同分石牌广藿香及海南广藿香。枝叶茂盛时采割，日晒夜闷，反复至干。【性味】辛，微温。【归经】归脾、胃、肺经。【功能主治】芳香化浊，开胃止呕，发表解暑。用于湿浊中阻，脘痞呕吐，暑湿倦怠，胸闷不舒，寒湿闭暑，腹痛吐泻，鼻渊头痛。【用法用量】内服：煎汤，3～10g。【注意】阴虚者禁服。【摘录】《中华本草》。
白芷【别名】薛、芷，芳香，苻蓠、泽芬，白茝，香白芷。【来源】本品为伞型科植物白芷或杭白芷的干燥根。夏、秋间叶黄时采挖，除去须根及泥沙，晒干或低温干燥。【性味】辛，温。【归经】归胃、大肠、肺经。【功能主治】散风除湿，通窍止痛，消肿排脓。用于感冒头痛，眉棱骨痛，鼻塞，鼻渊，牙痛，白带，疮疡肿痛。【用法用量】内服：煎汤，3～9g。【注意】阴虚血热者忌服。当归为之使。恶旋覆花。【摘录】《中华本草》。
紫苏叶【别名】苏叶。【来源】本品为唇形科植物紫苏的干燥叶(或带嫩枝)。夏季枝叶茂盛时采收，除去杂质，晒干。【性味】辛，温。【归经】归肺、脾经。【功能主治】解表散寒，行气和胃。用于风寒感冒，咳嗽呕恶，妊娠 呕吐，鱼蟹中毒。【用法用量】内服：煎汤，5～9g。【注意】病属阴虚，因发寒热或恶寒及头痛者，慎毋投之，以病宜敛宜补故也。火升作呕者亦不宜.【摘录】《中华本草》。
白术【别名】于术、冬术、浙术、种术。【来源】本品为菊科植物白术的干燥根茎。冬季下部叶枯黄、上部叶变脆时采挖，除去泥沙，烘干或晒干，再除去须根。【性味】苦、甘，温。【归经】归脾、胃经。【功能主治】健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。【用法用量】内服：煎汤，6～12g。【注意】阴虚燥渴，气滞胀闷者忌服。【摘录】《中华本草》。
半夏【别名】三叶半夏、三叶老、三步跳、麻玉果、燕子尾、地文、水玉。【来源】本品为天南星科植物半夏的干燥块茎。夏、秋二季采挖，洗净，除去外皮及须根，晒干。【性味】辛，温；有毒。【归经】归脾、胃、肺经。【功能主治】燥湿化痰，降逆止呕，消痞散结。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛，呕吐反胃，胸脘痞闷，梅核气；生用外治痈肿痰核。姜半夏多用于降逆止呕。【用法用量】内服：煎汤，3～9g。【注意】阴虚燥咳、津伤口渴、血证及燥痰者禁服，孕妇慎服。不宜与乌头类药材同用。【摘录】《中华本草》。
陈皮【别名】橘皮.【来源】本品为芸香科植物橘及其栽培变种的干燥成熟果皮。药材分为“陈皮”和“广陈皮”。采摘成熟果实，剥取果皮，晒干或低温干燥。【性味】苦、辛，温。【归经】归肺、脾经。【功能主治】理气健脾，燥湿化痰。用于胸脘胀满，食少吐泻，咳嗽痰多。【用法用量】内服：煎汤，3～9g。【摘录】《中华本草》。
茯苓【别名】茯苓个、茯苓皮、茯苓块、赤茯苓、白茯苓。【来源】本品为多孔菌科真菌茯苓的干燥菌核。多于7～9月采挖，挖出后除去泥沙，堆置“发汗”后，摊开晾至表面干燥，再“发汗”，反复数次至现皱纹、内部水分大部散失后，阴干，称为“茯苓个”；或将鲜茯苓按不同部位切制，阴干，分别称为“茯苓皮”及“茯苓块”。【性味】甘、淡，平。【归经】归心、肺、脾、肾经。【功能主治】利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。【用法用量】内服：煎汤，9～15g。【注意】虚 寒精滑或气虚下陷者忌服。【摘录】《中华本草》。
厚朴【别名】川朴、紫油厚朴。【来源】本品为木兰科植物厚朴或凹叶厚朴的干燥干皮、根皮及枝皮。4～6月剥取，根皮及枝皮直接阴干；干皮置沸水中微煮后，堆置阴湿处，“发汗”至内表面变紫褐色或棕褐色时，蒸软，取出，卷成筒状，干燥。【性味】苦、辛，温。【归经】归脾、胃、肺、大肠经。【功能主治】燥湿消痰，下气除满。用于湿滞伤中，脘痞吐泻，食积气滞，腹胀便秘，痰饮喘咳。【用法用量】内服：煎汤，3～9g。【注意】孕妇慎用。干姜为之使。恶泽泻、寒水石、消石。【摘录】《中华本草》。
甘草【来源】本品为豆科植物甘草、胀果甘草、光果甘草的干燥根。春、秋二季采挖，除去须根，晒干。【性味】甘，平。【归经】归心、肺、脾、胃经。【功能主治】补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。【用法用量】内服：煎汤，1.5～10g。【注意】不宜与京大戟、芫花、甘遂同用。【摘录】《中华本草》。
桔梗【别名】包袱花、铃铛花、僧帽花、白药、梗草。【来源】中药桔梗为桔梗科多年生草本植物桔梗的根。【性味】苦、辛，平，微寒。【归经】归肺经。【功能主治】宣肺、祛痰、利咽、排脓、利五脏、补气血、补五劳、养气。咳嗽痰多、咽喉肿痛、肺痈吐脓、胸满胁痛、痢疾腹痛、口舌生疮、目赤肿痛、小便癃闭。【用法用量】内服：煎汤，3～10g。【注意】中药桔梗性升散，凡气机上逆，呕吐、呛咳、眩晕、阴虚火旺咳血等，不宜单用。用量过大易致恶心呕吐。【摘录】《中华本草》。
生姜【别名】姜。【来源】本品为姜科植物姜的新鲜根茎。秋、冬二季采挖，除去须根及泥沙。【性味】辛，微温。【归经】归肺、脾、胃经。【功能主治】解表散寒，温中止呕，化痰止咳。用于风寒感冒，胃寒呕吐，寒痰咳嗽。【用法用量】内服：煎汤，3～9g。【注意】食姜久，积热患目。凡病痔人多食兼酒，立发甚速。痈疮人多食则生恶肉。【摘录】《中华本草》。
大腹皮【别名】槟榔皮，大腹毛，茯毛，槟榔衣，大腹绒。【来源】本品为棕榈科植物槟榔的干燥果皮。冬季至次春采收未成熟的果实，煮后干燥，纵剖两瓣，剥取果皮，习称“大腹皮”；春末至秋初采收成熟果实，煮后干燥， 剥取果皮，打松，晒干，习称“大腹毛”。【性味】辛，微温。【归经】归脾、胃、大肠、小肠经。【功能主治】下气宽中，行水消肿。用于湿阻气滞，脘腹胀闷，大便不爽，水肿胀满，脚气浮肿，小便不利。【用法用量】内服：煎汤，4.5～9g。【注意】气虚体弱者慎服。【摘录】《中华本草》。
大枣【别名】【来源】本品为鼠李科枣属植物枣的干燥成熟果实。秋季果实成熟时采收，晒干。其根、树皮亦入药，随时可采。【性味】甘，温。【归经】归脾、胃经。【功能主治】补中益气，养血安神。用于脾虚食少，乏力便溏，妇人脏躁。消炎，止血，止泻。用于气管炎，肠炎，痢疾，崩漏；外用治外伤出血。行气，活血，调经。用于月经不调，红崩，白带。【用法用量】内服：煎汤，6～15g。【注意】凡有湿痰、积滞，齿病、虫病者，均不相宜。心下痞，中满呕吐者忌之。多食动风，脾反受病。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗急性肠胃炎的中药，通过选择合适的药材及其配比，达到安全有效治愈急性肠胃炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗急性肠胃炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：广藿香10份、白芷9份、紫苏叶9份、白术(炒)12份、半夏(制)9份、陈皮9份、茯苓15份、厚朴(姜制)9份、甘草10份、桔梗10份、生姜5份、大腹皮9份、大枣15份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院急性肠胃炎患者90例，随机分为治疗组45例与对照组45例，治疗组男21例，女24例，平均年龄43.1岁；对照组男19例，女26例，平均年龄50.6岁。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国急性肠胃炎临床专业会议的诊断标准：(1)、发病较急，在不同程度上出现呕吐症状；(2)、每天腹泻的次数在5次以上，大便的性状呈黄色水样状，没有出现明显的黏液和脓血症状；(3)、少数患者出现发热、脱水、酸碱失衡以及电解质紊乱等；(4)、通过体检显示腹部出现轻压痛以及肠鸣音亢进。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程3天。
对照组口服红霉素、口服葡萄糖口服液(按说明书服用)疗程3天。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：患者经过治疗每天的排便次数在1～2次之间，通过化验指标的检测显示为正常；
显效：患者经过治疗每天的排便次数减少了3次，且大便的性状成形，通过化验指标检测表明得到了显著改善；
有效：患者经过治疗排便的次数有所减少，大便的性状不成形，通过化验指标检测显示有所改善；
无效：患者经过治疗排便的次数、大便的性状以及化验指标检测等都没有得到改善，甚至恶化。
3.2治疗结果见表1。
表1两组疗效比较
Figure PCTCN2017103316-appb-000001
可见，本发明制得的药物能够安全有效治疗急性肠胃炎，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：广藿香10克、白芷9克、紫苏叶9克、白术(炒)12克、半夏(制)9克、陈皮9克、茯苓15克、厚朴(姜制)9克、甘草10克、桔梗10克、生姜5克、大腹皮9克、大枣15克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗急性肠胃炎。口服，每日分早午晚三次服用。
实施例2
称取：广藿香10克、白芷9克、紫苏叶9克、白术(炒)12克、半夏(制)9克、陈皮9克、茯苓15克、厚朴(姜制)9克、甘草10克、桔梗10克、生姜5克、大腹皮9克、大枣15克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗急性肠胃炎。口服，每日分早午晚三次服用。
实施例3
称取：广藿香10克、白芷9克、紫苏叶9克、白术(炒)12克、半夏(制)9克、陈皮9克、茯苓15克、厚朴(姜制)9克、甘草10克、桔梗10克、生姜5克、大腹皮9克、大枣15克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗急性肠胃炎。口服，每日分早午晚三次服用。

Claims (4)

  1. 一种用于治疗急性肠胃炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：广藿香10份、白芷9份、紫苏叶9份、白术(炒)12份、半夏(制)9份、陈皮9份、茯苓15份、厚朴(姜制)9份、甘草10份、桔梗10份、生姜5份、大腹皮9份、大枣15份。
  2. 如权利要求1所述的用于急性肠胃炎的中药，其特征在于，其制备方法为：称取：广藿香10份、白芷9份、紫苏叶9份、白术(炒)12份、半夏(制)9份、陈皮9份、茯苓15份、厚朴(姜制)9份、甘草10份、桔梗10份、生姜5份、大腹皮9份、大枣15份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
  3. 如权利要求1所述的用于治疗急性肠胃炎的中药，其特征在于，其制备方法为：称取：广藿香10份、白芷9份、紫苏叶9份、白术(炒)12份、半夏(制)9份、陈皮9份、茯苓15份、厚朴(姜制)9份、甘草10份、桔梗10份、生姜5份、大腹皮9份、大枣15份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
  4. 如权利要求1所述的用于治疗急性肠胃炎的中药，其特征在于，其制备方法为：称取：广藿香10份、白芷9份、紫苏叶9份、白术(炒)12份、半夏(制)9份、陈皮9份、茯苓15份、厚朴(姜制)9份、甘草10份、桔梗10份、生姜5份、大腹皮9份、大枣15份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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