CN115120684A - Traditional Chinese medicine formula for treating diabetes and processing method thereof - Google Patents
Traditional Chinese medicine formula for treating diabetes and processing method thereof Download PDFInfo
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine formula for treating diabetes and a processing method thereof. The traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 5-15 parts of barley seedlings, 1-3 parts of rape seedlings, 1-3 parts of mulberry leaves, 2-6 parts of rhizoma polygonati, 3-8 parts of gynostemma pentaphylla, 2-6 parts of astragalus membranaceus, 2-6 parts of common yam rhizome, 1-3 parts of ginseng, 1-2 parts of dogwood and 1-2 parts of radix ophiopogonis. The formula of the invention is processed to prepare the traditional Chinese medicine powder for treating diabetes, which can enhance the insulin sensitivity of a patient, promote the insulin secretion and improve the glycolipid metabolism; the hypoglycemic agent replaces part of hypoglycemic agents, and the accumulated toxic and side effects caused by long-term use of the hypoglycemic agent by T2DM people are reduced; improving insulin resistance, reducing apoptosis of islet beta cells; inhibiting oxidative stress and inflammatory reaction, and delaying or relieving development of complications; reduce the economic burden of long-term diabetes family social treatment, reduce the death rate of diabetes and prolong the health life of diabetes patients.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine formula for treating diabetes and a processing method thereof.
Background
In recent years, the prevalence rate of diabetes in China is gradually rising. According to survey data, the following steps are shown: in 2019, the number of Chinese diabetic patients is about 1.16 hundred million, and China has become the country with the most diabetic patients all over the world; at the same time, the number of diabetic patients is still continuously increasing rapidly. The number of Chinese diabetic patients in 2040 years is predicted to reach 1.51 hundred million people. Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia due to multiple causes, and is caused by defects in insulin secretion and/or utilization. The long-term carbohydrate, fat and protein metabolic disorder can cause multi-system damage, so that chronic progressive pathological changes, hypofunction and failure of tissues and organs such as eyes, kidneys, nerves, hearts, blood vessels and the like occur. If the treatment is not carried out in time, the blood sugar fluctuation can cause damage to body organs and accelerate the occurrence of complications. Diabetes is a lifelong disease, most of the clinical medical level at present can not eradicate and cure the diabetes, lifelong drug therapy is needed, the occurrence of complications is delayed by using hypoglycemic drugs or insulin injection to control blood sugar, the number of the taken drugs presents an increasing trend along with the lapse of treatment time, and the toxic and side effects after long-term administration are also shown to be increased statistically.
The existing medicines for treating diabetes have the following defects: 1. hypoglycemic reaction: hypoglycemic reactions can cause severe irreversible damage to the nervous system and even death; 2. sulfonylureas produce metabolic and nutritional disorders, damage to the nervous system; the alpha-glycosidase inhibitor and the biguanide drugs produce gastrointestinal adverse reactions; 4. the pharmacokinetics has long and limited action time, and blood sugar is controlled by taking hypoglycemic drugs for a long time; 5. toxic and side effects of liver and kidney function metabolism. Therefore, further development of effective drugs for treating diabetes is required.
Disclosure of Invention
The invention aims to solve the problems of the prior art and provides a traditional Chinese medicine formula for treating diabetes and a processing method thereof.
The technical scheme adopted by the invention for solving the technical problems is as follows:
one of the purposes of the invention is to provide a traditional Chinese medicine formula for treating diabetes, which is prepared from the following raw materials in parts by weight: 5-15 parts of barley seedlings, 1-3 parts of rape seedlings, 1-3 parts of mulberry leaves, 2-6 parts of rhizoma polygonati, 3-8 parts of gynostemma pentaphylla, 2-6 parts of astragalus membranaceus, 2-6 parts of common yam rhizome, 1-3 parts of ginseng, 1-2 parts of dogwood and 1-2 parts of radix ophiopogonis. The weight portion of the raw materials is the weight portion of the dried raw materials.
Preferably, the formula is prepared from the following raw materials in parts by weight: 10 parts of barley seedlings, 2 parts of rape seedlings, 2 parts of mulberry leaves, 3 parts of rhizoma polygonati, 5 parts of gynostemma pentaphylla, 3 parts of astragalus membranaceus, 3 parts of Chinese yam, 2 parts of ginseng, 1 part of dogwood and 1 part of radix ophiopogonis.
In the above-mentioned medicament:
rape seedlings: cool in nature and sweet in flavor, entering liver, spleen and lung meridians. Can promote blood circulation, relieve swelling and remove toxicity. Can be used for relieving flatulence and swelling, stomach ache, neuralgia and head congestion, and the rape seedling is rape with a height of 15-30 cm.
Barley seedling: the barley straw contains polysaccharide and cellulose components. The traditional Chinese medicine composition is sweet and bitter in taste, warm in nature and non-toxic, enters the spleen channel and the lung channel, has the main functions of relieving swelling, promoting diuresis and regulating qi, and has the effect of reducing blood sugar through preliminary animal experiments.
Mulberry leaf: it enters lung and liver meridians. Finely filing, decocting in large kettle to obtain brown sugar, and can be used for removing old wind and blood stasis, and lowering blood sugar.
Rhizoma polygonati: also named: rhizoma Polygonati, herba Elsholtziae Pendulifoliae, rhizoma Gynurae Divaricatae, rhizoma Zingiberis recens, and radix Codonopsis Lanceolatae. Is a plant of Polygonatum with transverse rhizome, cylindrical shape and enlarged nodule. The impeller is raw and has no handle. The medicinal plants are sweet in taste and neutral in nature, enter spleen channels, lung channels and kidney channels, and have the effects of tonifying qi and yin, strengthening spleen, moistening lung and promoting fluid production, tonifying kidney and the like.
And (3) gynostemma pentaphylla: a grass climbing plant of the Cucurbitaceae family, the Gynostemma genus; slender and weak stem, branch, longitudinal edge and groove, no hair or short and soft hair; slightly sweet and cool in nature, enters lung, spleen and kidney channels, and has the effects of tonifying qi and spleen, reducing phlegm and stopping cough, clearing away heat and toxic materials, reducing blood sugar and the like.
Astragalus root: sweet in flavor and slightly warm in nature; the medicine belongs to the lung, spleen, liver and kidney channels, has more than 2000 years of history for medical use so far, and has the functions of enhancing the immune function of an organism, protecting the liver, promoting urination, resisting aging, resisting stress, reducing blood pressure, regulating blood sugar and having wider antibacterial action.
Rhizoma dioscoreae: sweet in flavor and neutral in nature. It has effects in invigorating spleen, nourishing stomach, promoting fluid production, benefiting lung, invigorating kidney, stopping nocturnal emission, clearing away heat and toxic materials, and can be used for treating spleen deficiency, anorexia, chronic diarrhea, cough and asthma due to lung deficiency, nocturnal emission due to kidney deficiency, leukorrhagia, pollakisuria, and consumptive heat and thirst.
Ginseng: entering spleen and lung channels, invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, tranquilizing, and is mainly used for treating: asthenia, collapse, cold limbs, slight pulse, spleen deficiency, poor appetite, thirst due to body fluid consumption, internal heat, diabetes, and asthenia caused by chronic diseases. The root contains ginsenoside 0.4% and small amount of volatile oil.
Dogwood fruit: the dogwood is warm in nature and enters liver and kidney channels, has the effects of tonifying liver and kidney, arresting seminal emission and relieving depletion, is clinically used for internal heat and diabetes, dizziness and tinnitus, waist and knee soreness and the like, is a traditional Chinese medicine clinically used medicinal material, can increase insulin secretion and improve insulin content.
Radix ophiopogonis: sweet, slightly bitter and slightly cold in nature. Modern pharmacological research also shows that the ophiopogon root mainly contains ophiopogonin, steroid saponin, alkaloid, sitosterol, glucose, amino acid, vitamin and the like, and has the effects of resisting fatigue, eliminating free radicals, improving the cellular immune function and reducing blood sugar.
The invention also aims to provide a processing method of the traditional Chinese medicine formula for treating diabetes, which comprises the following steps:
(1) cleaning rape seedlings and mulberry leaves, drying by hot air, mixing according to the formula proportion after drying, and grinding to 200 meshes and 300 meshes for later use;
(2) crushing barley seedlings to 400 meshes of 300-;
(3) taking ginseng and Chinese yam according to the formula proportion, adding boiling water at 100 ℃, boiling for 45 minutes, and filtering to obtain a solution A and a solute B;
a) 1/3 adding the solution A into the processed rhizoma Polygonati powder, and oven drying to obtain solid C;
b) decocting all solutes B and the radix astragali slices in 100 ℃ boiling water for 30 minutes, and filtering to obtain solutes D and a solution E;
c) mixing the 1/4 solution E with all the solid C in a), and drying to obtain a solid G;
d) mixing the 3/4 solution E with 1/2 solute D, standing for 24 hours, adding the mixed powder of the rape seedling and the mulberry leaf obtained in the step (2), and dehydrating and drying again to obtain solid F;
(4) boiling the residual 2/3 solution A, the residual 1/2 solute D and all solids G for 6 hours, dehydrating and air-drying, adding the previously mixed solids F, and mixing to obtain mixed powder H;
(5) and (4) mixing the mixed powder H obtained in the step (4) with the wheat and winter powder according to a formula proportion, mixing the mixture with the denucleated dogwood according to a formula proportion, and crushing the mixture into 250-mesh and 300-mesh powder to obtain the traditional Chinese medicine powder for treating diabetes.
Preferably, the rape seedlings in the step (1) are cabbage type rape seedlings with medium plant size, thick leaves, wax powder and deep leaf edges, and the mulberry leaves are selected from fresh mulberry leaves and are dried by hot air by using a whole set of vegetable dehydration treatment equipment.
Preferably, the moisture content of the barley grass meal in the step (2) is not more than 5%, and the milling is performed by a PM100 type planetary ball mill.
Preferably, the sealwort powder in the step (3) is prepared by the following steps: soaking and cleaning dried rhizoma Polygonati according to a formula proportion, cleaning silt at nodes, steaming for 4 hours, mixing yellow wine, wherein the mass ratio of the yellow wine to the rhizoma Polygonati is 100:6, placing in a pottery jar, stewing for 24 hours at 85 ℃, drying for 6 hours, repeatedly turning the middle part, steaming for 4 hours, drying for 6 hours to obtain rhizoma Polygonati solid, adding gynostemma pentaphylla according to the formula proportion, manually twisting the gynostemma pentaphylla until 70% of water is removed, drying together, and adding into a flour mill to grind to 200 meshes and 300 meshes.
Preferably, the astragalus membranaceus tablets in the step (3) are prepared by the following steps: selecting radix astragali, drying to remove 70% -80% of water, cutting off lateral root and fibrous root, stacking for 1-2 days to regain moisture, spreading, drying completely, straightening root, bundling into small bundles, and slicing radix astragali with a slicing machine to obtain radix astragali slices.
Preferably, the wheat and winter flour in the step (5) is prepared by the following steps: putting radix ophiopogonis into a washing tank, washing with running water, fishing out, draining, putting into 2% salt water, soaking for 8-12 hours, fishing out, and boiling with sugar: according to the weight percentage of water: the mass ratio of the radix ophiopogonis to the radix ophiopogonis is 5: 2, adding water, heating to 80 ℃, and mixing the raw materials according to the weight ratio of the radix ophiopogonis: adding white granulated sugar into the white granulated sugar at a mass ratio of 20:1, and simultaneously adding the white granulated sugar: adding citric acid into citric acid at a mass ratio of 9:1, boiling for 5 minutes, adding purified water with a temperature of 30 ℃ and a mass ratio of 1:3 of radix ophiopogonis, soaking for 3-5 days, and then air-drying and grinding to 200-300 meshes.
Preferably, the drying temperature in the step is 75-95 ℃.
The traditional Chinese medicine formula provided by the invention is discovered through continuous clinical practice research of clinical experts in recent years, most diabetics can use the formula individually under the guidance of professional doctors, various physiological indexes of the diabetics can be obviously and effectively improved by combining with life style management, the pancreatic islet sensitivity of an organism is improved, the insulin resistance is improved, the phenomenon that the patients can reduce or even stop taking medicine under the condition of autonomously and stably regulating blood sugar can be finally realized, and the life quality of the patients can be obviously improved.
Compared with the prior art, the invention has the beneficial effects that:
(1) the functions of enhancing the insulin sensitivity of a patient, activating and repairing damaged islet cells, promoting insulin secretion and improving glycolipid metabolism: in the formula, barley seedlings, sealwort, astragalus, Chinese yam and rape seedlings can effectively improve the blood sugar fluctuation of T2DM people, reduce blood sugar, promote liver glycogen synthesis, inhibit gluconeogenesis and improve the pancreatic island function by influencing liver glycogen synthesis, expression of enzymes related to gluconeogenesis, improving intestinal insulin resistance and the like;
(2) the medicine replaces partial hypoglycemic drugs, and reduces the accumulated toxic and side effects caused by long-term use of the hypoglycemic drugs by T2DM people: clinical sample experiment result statistics shows that sulfonylureas and insulin hypoglycemic agents can be reduced as appropriate when the composition is used, 70% of people can stop taking medicines by combining personalized nutritional life style management, and sulfonylureas are mainly metabolized through the liver to cause large burden to people with liver and kidney insufficiency or too large dosage, so that the composition can be considered to replace treatment clinically in order to avoid aggravating the burden of liver metabolism and kidney excretion;
(3) improving insulin resistance, reducing apoptosis of islet beta cells: in the formula, the components of ginseng and the like can act to increase the expression of skeletal muscle protein kinase B (Akt) and phosphorylated protein kinase B (p-Akt), enhance the glucose transport capacity of glucose transporter 4(GLUT4), regulate and control death signal transduction effector enzyme 3(Caspase-3) and inhibit apoptosis cascade reaction;
(4) inhibiting oxidative stress and inflammatory reaction, and delaying or relieving development of complications: the gynostemma pentaphylla can effectively reduce the levels of TNF-alpha, IL-1 and IL-6 in serum of a rat of a DN model, has obvious dose dependence, can reduce the incidence rate of complications such as diabetic nephropathy and diabetic nephropathy due to stable regulation and control of blood sugar, and improves peripheral circulation;
(5) the economic burden of the long-term diabetes family social treatment of the patients is reduced, the death rate of diabetes is reduced, and the health life of the diabetes patient group is prolonged: in 2015, the economic burden of the middle-aged and elderly diabetic patients in China is 5098.85 billion yuan, the formula adopts homology of medicine and food, and the product can be used in a personalized and reasonable manner according to medical advice to stably control blood sugar and reduce the diagnosis and treatment cost of long-term clinical hypoglycemic drugs.
Detailed Description
The technical solution of the present invention will be further specifically described below by way of specific examples.
Example 1
A traditional Chinese medicine formula for treating diabetes is prepared from the following raw materials in parts by weight: 10 parts of barley seedlings, 2 parts of rape seedlings, 2 parts of mulberry leaves, 3 parts of rhizoma polygonati, 5 parts of gynostemma pentaphylla, 3 parts of astragalus membranaceus, 3 parts of common yam rhizome, 2 parts of ginseng (ginseng), 1 part of dogwood and 1 part of radix ophiopogonis.
A processing method of the traditional Chinese medicine formula for treating diabetes comprises the following steps:
(1) cleaning rape seedlings and mulberry leaves, drying by hot air, mixing according to the formula proportion after drying, and grinding to 200-300 meshes for later use;
(2) crushing the dried barley seedlings to 400 meshes of 300-;
(3) taking ginseng and Chinese yam according to the formula proportion, adding boiling water at 100 ℃, boiling for 45 minutes, and filtering to obtain a solution A and a solute B; wherein the water is added according to 5 times of the total mass of the ginseng and the dioscorea opposita;
a) 1/3 adding the solution A into the processed rhizoma Polygonati powder, and oven drying to obtain solid C;
b) decocting all solutes B and the radix astragali slices in 100 ℃ boiling water for 30 minutes, and filtering to obtain solutes D and a solution E;
c) mixing the 1/4 solution E with all the solid C in a), and drying to obtain a solid G;
d) mixing the 3/4 solution E with 1/2 solute D, standing for 24 hours, adding the mixed powder of the rape seedling and the mulberry leaf obtained in the step (2), and dehydrating and drying again to obtain solid F;
(4) boiling the residual 2/3 solution A, the residual 1/2 solute D and all solids G for 6 hours, dehydrating and air-drying, adding the previously mixed solids F, and mixing to obtain mixed powder H;
(5) removing kernels of the dogwoods for later use, mixing the mixed powder H obtained in the step (4) with the wheat and winter flour according to a formula proportion, mixing the mixture with the dogwoods according to the formula proportion, and crushing the mixture into 300-mesh powder of 250 meshes to obtain the traditional Chinese medicine powder for treating the diabetes.
Wherein, the rape seedlings in the step (1) are cabbage type rape seedlings with medium plant size, thick leaves, wax powder and deep leaf margin, and the mulberry leaves are selected from fresh mulberry leaves and are dried by hot air by using a whole set of vegetable dehydration treatment equipment.
And (3) crushing the barley grass coarse powder in the step (2) by using a PM100 type planetary ball mill, wherein the water content of the barley grass coarse powder is not higher than 5%.
Preferably, the sealwort powder in the step (3) is prepared by the following steps: soaking and cleaning dry rhizoma Polygonati according to a formula proportion, cleaning silt at nodes, steaming for 4 hours, mixing yellow wine, wherein the mass ratio of the yellow wine to the dry rhizoma Polygonati is 100:6, placing in a pottery jar, stewing for 24 hours at 85 ℃, drying for 6 hours, repeatedly turning the middle part, steaming for 4 hours, drying for 6 hours to form rhizoma Polygonati solid, adding gynostemma pentaphylla according to the formula proportion, manually twisting the gynostemma pentaphylla until 70% of water is removed, drying together, and adding into a mill to grind to 200 meshes and 300 meshes.
Preferably, the astragalus membranaceus tablets in the step (3) are prepared by the following steps: selecting raw radix astragali, drying to remove 70% -80% of water, cutting off lateral roots and fibrous roots, stacking for 1-2 days to regain moisture, spreading out, drying in the sun to be completely dry, straightening the roots, bundling into small bundles, and slicing radix astragali with a slicing machine to obtain radix astragali slices.
Preferably, the dwarf lilyturf tuber powder in the step (5) is prepared by the following steps: putting radix ophiopogonis into a washing tank, washing with running water, fishing out, draining, putting into 2% salt water, soaking for 8-12 hours, fishing out, and boiling with sugar: according to the weight percentage of water: the mass ratio of radix ophiopogonis is 5: 2, adding water, heating to 80 ℃, and mixing the raw materials according to the weight ratio of the radix ophiopogonis: adding white granulated sugar into the white granulated sugar at a mass ratio of 20:1, and simultaneously adding the white granulated sugar: adding citric acid into citric acid at a mass ratio of 9:1, boiling for 5 minutes, adding purified water with a temperature of 30 ℃ and a mass ratio of 1:3 of radix ophiopogonis, soaking for 3-5 days, and then air-drying and grinding to 200-300 meshes.
The drying temperature in the steps is 75-95 ℃, and the adjustment is carried out according to the properties of the dried substances.
Example 2
A traditional Chinese medicine formula for treating diabetes is prepared from the following raw materials in parts by weight: 5 parts of barley seedlings, 1 part of rape seedlings, 1 part of mulberry leaves, 2 parts of rhizoma polygonati, 3 parts of gynostemma pentaphylla, 2 parts of astragalus membranaceus, 2 parts of common yam rhizome, 1 part of ginseng (ginseng), 1 part of dogwood and 1 part of radix ophiopogonis. The processing method was the same as in example 1.
Example 3
A traditional Chinese medicine formula for treating diabetes is prepared from the following raw materials in parts by weight: 15 parts of barley seedlings, 3 parts of rape seedlings, 3 parts of mulberry leaves, 6 parts of rhizoma polygonati, 8 parts of gynostemma pentaphylla, 6 parts of astragalus membranaceus, 6 parts of common yam rhizome, 3 parts of ginseng (ginseng), 2 parts of dogwood and 2 parts of radix ophiopogonis. The processing method was the same as in example 1.
Test example clinical test
The clinical experimental research of diabetes is carried out by a Hangzhou autumn standing clinic clinical medicine team under the guidance of a main and task team of a Hospital, province and trimethyl hospitals in 2020 and 12 months in 2020, the experiment adopts ' from ' cause ' to ' effect ', the traditional Chinese medicine formula of the diabetes is used as an intervention factor, the experiment effect caused by the intervention factor is observed, the experiment source population is from community personnel in a certain Hangzhou region, and the reference standard is as follows: age 35-75, type II diabetes, patients without severe liver-kidney heart-lung function failure, BMI > 18.5, volunteer participated in the experimental researchers, the experiment carried out random digital table method grouping by operator and subject double-blinded mode, and control group 114, wherein 99 people taking medicines for a long time, the control group carried out diet by mode of 'Chinese diabetes diet guideline 2017', low GI staple food was selected, whole grain and miscellaneous bean should account for 1/3 of the staple food intake, vegetable intake 300 and 500 g each day, and regular meal was carried out. The experimental group is brewed by 2 bags of the blood sugar reducing traditional Chinese medicine formula in the embodiment 1 every day on the basis of the condition of the control group, the temperature of 100 ℃ water is brewed to 1500-:
comparison of fasting blood glucose before and after eating and blood glucose change after two hours (n ═ 222)
Note: the experiment significance level a is 0.05, and for improving the experiment checking efficiency and avoiding the influence of mixed factors such as age, sex and the like, the experiment is synchronously analyzed by block design. The improvement rate evaluation standard is as follows: average fasting blood glucose after dry prognosis without medicine-average fasting blood glucose before intervention delta is more than 1.5mmol/L, and combined glycosylated hemoglobin tends to change normally.
And (4) conclusion: after counting the data, it can be seen that: under the guidance of a physician, after a patient takes the blood sugar reducing formula for three months, the average fasting blood sugar condition is reduced by 3.12 +/-1.78 mmol/L, the blood sugar of an experimental group is reduced by 4.54 +/-1.15 mmol/L after 2h, the glycosylated hemoglobin is reduced by 2.49 +/-1.41, the reduction level is obviously higher than that of a control group, and then, along with the prolonging of the time for taking the blood sugar reducing formula, the improvement rate and the drug withdrawal rate are in an upward trend, the average weight reduction condition appears in two groups, according to the control group of diet of Chinese diabetes dietary guidelines, the blood sugar and the like are slightly reduced, but the improvement degree is not obvious, and in the experiment, each group does not have adverse symptoms and reactions such as vomiting, nausea, dizziness, abdominal pain, palpitation, hypodynamia and the like.
Clinical treatment of typical cases
The formulation is personalized with different dosages and methods under the direction of a professional doctor, one person takes the formulation and adjusts the formulation in real time, for example as follows:
the embodiment of a traditional Chinese medicine formula for treating diabetes mellitus comprises the following components: patient li xx, male, 47 years old, han nationality, farmer. Initial diagnosis in 2019, 2 months and 6 days. The patient has type II diabetes for 9 years, normal stool, good appetite, and 7mmol/L average fasting blood glucose, and non-alcoholic fatty liver disease. The history of medication: metformin 2 granules per day, glimepiride once per day, 1 granule per time, treatment regimen: the method comprises the steps of continuously taking 5 days of VLCD diet (taking 600-800 kcal energy every day) and 25 days of CRD (controlling 1000-1800 kcal/d for men and 1200-1500 kcal/d for women) every month, taking 2 bags of diabetes traditional Chinese medicine formula every 5 days, analyzing and individualizing a nutrition meal spectrum according to clinical human body components, pausing glimepiride within 5 days, taking the diabetes formula every other day in 25 days, and increasing and decreasing the medicines in real time according to the dynamic monitoring condition of blood sugar recovery. The patient successfully stops taking glimepiride on the 5 th day of treatment to reduce the fasting blood glucose to 6.2mmol/L, the metformin is reduced to one fasting blood glucose which is still kept at 5.1-6.9mmol/L every day after the fasting blood glucose is stabilized for 15 days, the patient complains of good spirit, the abdominal fat is obviously reduced, the body weight is reduced by 4.5kg, after the treatment, the imaging shows that the moderate fatty liver is reduced to the mild fatty liver, and the glycosylated hemoglobin is reduced from 8.7 to 6.8 in three months.
The second embodiment of a traditional Chinese medicine prescription for treating diabetes mellitus: patient king xx, female, 57 years old, Han nationality, farmer. Initial diagnosis in 2019, 4 and 8 days. The patient suffers from type II diabetes for 11 years, has normal defecation and good appetite, has average 11mmol/L of fasting blood glucose after being taken, has BMI18.9, and has a history of: long-acting insulin 15 units, glimepiride 2 times daily, one dose at a time, treatment regimen: administering the composition for 5 days continuously, 2 bags of blood sugar lowering composition every day, brewing with boiled water, repeatedly drinking the composition for the day until the taste is light, the insulin is halved, and the glimepiride is suspended, and then administering the composition for 25 days every day in combination with low GI diet management. After the treatment, the long-acting insulin is suspended, the glimepiride is reduced from one to half, the fasting blood glucose is stably maintained at 6.1-7.8mmol/L, the skeletal muscle is increased by 1.5Kg, the body weight is increased by 3Kg, and the leg circulation is improved.
The third embodiment of a traditional Chinese medicine prescription for treating diabetes mellitus is as follows: patient xuxx, female, 43 years old, han nationality, resident. Initial diagnosis in 2019, 5 and 18 days. The patient had type ii diabetes for 3 years, normal stool and stool, good appetite, BMI20, type i diabetes, glycated hemoglobin 9.2, mean blood glucose after two hours of meal 17, history of medication: 24 units of intermediate acting insulin per day, 2 metformin for one day, 2 acarbose for one day, treatment regimen: the first three days are taken 2 bags of blood sugar reducing formula every day, the middle-effect insulin can be used by half, bad living habits such as drinking and the like are avoided, then 15 days are taken one bag of blood sugar reducing formula every day, outpatient service reexamination is continued for 15 days, the blood sugar reducing formula is taken one bag every day at intervals every day, the blood sugar reducing formula is brewed with uniform boiled water, and the volume of the brewed liquid is more than 1500 ml every day. After treatment, the sensitivity of the patient to the pancreatic islets is enhanced, 24 units of intermediate-acting insulin is stopped, under the condition of the original dose of oral hypoglycemic agent, the daily fasting blood glucose of the patient is averagely maintained at 6.5-7.2, the blood glucose of the patient is averagely 12.1 in two hours after a meal, and the glycosylated hemoglobin is reduced to 7.2 after three months.
Comparative example
The excellent effect of the traditional Chinese medicine formula compared with other blood sugar reducing modes is shown in the following table. As can be seen from the following table, the traditional Chinese medicine formula for treating diabetes has the advantages of convenience for insisting on and obvious blood sugar reduction effect due to the nature of homology of medicine and food, and is very suitable for clinical selection of diabetic patients.
The above-described embodiments are merely preferred embodiments of the present invention, which is not intended to be limiting in any way, and other variations and modifications are possible without departing from the scope of the invention as set forth in the appended claims.
Claims (8)
1. The traditional Chinese medicine formula for treating diabetes is characterized by being prepared from the following raw materials in parts by weight: 5-15 parts of barley seedlings, 1-3 parts of rape seedlings, 1-3 parts of mulberry leaves, 2-6 parts of rhizoma polygonati, 3-8 parts of gynostemma pentaphylla, 2-6 parts of astragalus membranaceus, 2-6 parts of common yam rhizome, 1-3 parts of ginseng, 1-2 parts of dogwood and 1-2 parts of radix ophiopogonis.
2. The traditional Chinese medicine formula for treating diabetes according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 10 parts of barley seedlings, 2 parts of rape seedlings, 2 parts of mulberry leaves, 3 parts of rhizoma polygonati, 5 parts of gynostemma pentaphylla, 3 parts of astragalus membranaceus, 3 parts of Chinese yam, 2 parts of ginseng, 1 part of dogwood and 1 part of radix ophiopogonis.
3.A method of processing a traditional Chinese medicine formulation according to any one of claims 1-2 for the treatment of diabetes, characterized in that it comprises the following steps:
(1) cleaning rape seedlings and mulberry leaves, drying by hot air, mixing according to the formula proportion after drying, and grinding to 200 meshes and 300 meshes for later use;
(2) crushing barley seedlings to 400 meshes of 300-;
(3) taking ginseng and Chinese yam according to the formula proportion, adding boiling water at 100 ℃, boiling for 45 minutes, and filtering to obtain a solution A and a solute B;
a) 1/3 adding the solution A into the processed rhizoma Polygonati powder, and oven drying to obtain solid C;
b) decocting all solutes B and radix astragali slices in boiling water at 100 deg.C for 30 min, and filtering to obtain solute D and solution E;
c) mixing the 1/4 solution E with all the solid C in a), and drying to obtain a solid G;
d) mixing the 3/4 solution E with 1/2 solute D, standing for 24 hours, adding the mixed powder of the rape seedling and the mulberry leaf obtained in the step (2), and dehydrating and drying again to obtain solid F;
(4) boiling the residual 2/3 solution A, the residual 1/2 solute D and all solids G for 6 hours, dehydrating and air-drying, adding the previously mixed solids F, and mixing to obtain mixed powder H;
(5) and (4) mixing the mixed powder H obtained in the step (4) with the wheat and winter powder according to a formula proportion, mixing the mixture with the denucleated dogwood according to a formula proportion, and crushing the mixture into 250-mesh and 300-mesh powder to obtain the traditional Chinese medicine powder for treating diabetes.
4. The processing method of a traditional Chinese medicine prescription for treating diabetes mellitus as claimed in claim 3, wherein the rape seedlings in step (1) are cabbage type rape seedlings with medium plant size, thick leaves, wax powder and deep leaf margin, and the mulberry leaves are selected from fresh mulberry leaves, and are dried by hot air through a whole set of vegetable dehydration treatment equipment.
5. The processing method of a traditional Chinese medicine composition for treating diabetes mellitus as claimed in claim 3, wherein the moisture content of the barley grass meal in step (2) is not higher than 5%, and the barley grass meal is pulverized by a PM100 planetary ball mill.
6. The processing method of the traditional Chinese medicine prescription for treating diabetes mellitus according to claim 3, characterized in that the rhizoma polygonati powder in the step (3) is prepared by the following steps: soaking and cleaning dried rhizoma Polygonati according to a formula proportion, cleaning silt at nodes, steaming for 4 hours, mixing yellow wine, wherein the mass ratio of the yellow wine to the rhizoma Polygonati is 100:6, placing in a pottery jar, stewing for 24 hours at 85 ℃, drying for 6 hours, repeatedly turning the middle part, steaming for 4 hours, drying for 6 hours to obtain rhizoma Polygonati solid, adding gynostemma pentaphylla according to the formula proportion, manually twisting the gynostemma pentaphylla until 70% of water is removed, drying together, and adding into a flour mill to grind to 200 meshes and 300 meshes.
7. The processing method of the traditional Chinese medicine prescription for treating diabetes mellitus according to the claim 3, characterized in that the radix astragali tablet in the step (3) is prepared by the following steps: selecting radix astragali, drying to remove 70% -80% of water, cutting off lateral root and fibrous root, stacking for 1-2 days to regain moisture, spreading, drying completely, straightening root, bundling into small bundles, and slicing radix astragali with a slicing machine to obtain radix astragali slices.
8. The processing method of the traditional Chinese medicine prescription for treating diabetes mellitus according to the claim 3, characterized in that the wheat and winter flour in the step (5) is prepared by the following steps: putting radix ophiopogonis into a washing tank, washing with running water, fishing out, draining, putting into 2% salt water, soaking for 8-12 hours, fishing out, and boiling with sugar: according to the weight percentage of water: the mass ratio of radix ophiopogonis is 5: 2, adding water, heating to 80 ℃, and mixing the raw materials according to the weight ratio of the radix ophiopogonis: adding white granulated sugar into the white granulated sugar at a mass ratio of 20:1, and simultaneously adding the white granulated sugar: adding citric acid into citric acid in a mass ratio of 9:1, boiling for 5 minutes, adding purified water with the temperature of 30 ℃ and the mass ratio of the purified water to the ophiopogon root of 1:3, soaking for 3-5 days, and then air-drying and grinding to 200-mesh and 300-mesh.
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