CN115554341A - Compound medicament for treating diabetes - Google Patents

Compound medicament for treating diabetes Download PDF

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CN115554341A
CN115554341A CN202211403780.5A CN202211403780A CN115554341A CN 115554341 A CN115554341 A CN 115554341A CN 202211403780 A CN202211403780 A CN 202211403780A CN 115554341 A CN115554341 A CN 115554341A
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parts
ginseng
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dandelion
hawthorn
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陈继成
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Abstract

The invention provides a compound medicament for treating diabetes, which mainly comprises the following medicinal materials of, by mass, 1-5 parts of pseudo-ginseng powder, 10-20 parts of salvia miltiorrhiza, 20-40 parts of astragalus, 1-8 parts of ginseng, 20-50 parts of hawthorn, 10-20 parts of dandelion and 12-20 parts of potentilla discolor. The compound medicament provided by the invention is matched with acupuncture, transfusion, massage and other treatment modes to restore the secretion function of islet cells of a patient, and the treatment course is obvious.

Description

Compound medicament for treating diabetes
Technical Field
The invention relates to the technical field of medical products, in particular to a compound medicament for treating diabetes.
Background
Diabetes is an endocrine metabolic disease which is characterized by hyperglycemia due to the fact that insulin can not play a normal role because of absolute or relative insufficiency of insulin secretion or the fact that a patient resists self insulin, and at present, no cure method or no cure case is found for diabetes and complications thereof, so that the diabetes is still characterized as a 'lifelong disease' by medical experts at home and abroad until now.
Diabetes medicine is generally classified as type 3. Wherein type 1 is insulin absolute deficient type, that is, the pancreatic islet beta cells of the patient completely lose the secretion function, and the patient accounts for about 4-6% of the diabetic patients; 2. diabetes is a relatively insulin deficient form, that is, a form in which the beta cells of the islets of langerhans have a secretory function but do not meet normal physiological requirements, which is about 60-70% or more of diabetic patients; patients of type 3, which comprise about 25-30% of diabetic patients, have normal insulin secretion but resist insulin and thus cannot exert favorable physiological effects; however, it has been found clinically that a significant proportion of diabetic patients have both reduced insulin secretion and insulin resistance.
At present, the conventional methods for treating type 2 diabetes and complications thereof in textbooks of various medical colleges and medical institutions all achieve the purpose of reducing blood sugar by applying various hypoglycemic drugs or insulin infusion, and are temporary solution and permanent solution. Although the method using the pancreatic organ transplantation operation has been successful at home and abroad, the method has academic value and no practical value. Therefore, finding a method for treating diabetes is always the aim of cumin of doctors of all countries in the world, and is an invaluable expectation of vast diabetics.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to provide a composite reagent for treating diabetes, the composite reagent has strong pertinence to type 2 diabetes, and is matched with treatment modes such as acupuncture, transfusion, massage and the like to restore the secretion function of islet cells of a patient, the treatment course is obvious, and a better treatment effect can be achieved.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a compound medicament for treating diabetes, which mainly comprises the following medicinal materials, by mass, 1-5 parts of pseudo-ginseng powder, 10-20 parts of salvia miltiorrhiza, 20-40 parts of astragalus membranaceus, 1-8 parts of ginseng, 20-50 parts of hawthorn, 10-20 parts of dandelion and 12-20 parts of potentilla discolor.
In the invention, the selected pseudo-ginseng powder has the effects of removing blood stasis, stopping bleeding, relieving swelling and pain, the edible pseudo-ginseng powder can help blood circulation and has the effects of tonifying and strengthening body, the selected salvia miltiorrhiza has the effects of activating blood circulation, removing blood stasis, stimulating menstrual flow, relieving pain, clearing heart, relieving restlessness, cooling blood and eliminating carbuncle, the selected astragalus membranaceus has the effects of tonifying qi, invigorating yang, reinforcing the defensive system, consolidating superficial resistance, inducing diuresis, relieving swelling, promoting production of body fluid, nourishing blood, activating stagnancy, dredging bi, expelling toxin, expelling pus and astringing sores and promoting granulation, the selected ginseng has the effects of greatly tonifying primordial qi, recovering pulse, tonifying spleen, benefiting lung, promoting production of body fluid, nourishing blood, soothing nerves and improving intelligence, the selected hawthorn has the effects of reducing blood fat, blood pressure, strengthening heart, resisting arrhythmia and the like, is also a good medicine for tonifying spleen, promoting appetite, relieving dyspepsia, promoting blood circulation, eliminating phlegm, treating diseases such as chest fullness and spleen, hernia, blood stasis, amenorrhea and the selected dandelion has the effects of clearing heat, removing toxicity, relieving swelling, stopping bleeding and stopping bleeding.
Preferably, the compound medicament mainly comprises the following medicinal materials, by mass, 2-4 parts of pseudo-ginseng powder, 12-17 parts of salvia miltiorrhiza, 28-34 parts of astragalus membranaceus, 2-6 parts of ginseng, 28-40 parts of hawthorn, 12-18 parts of dandelion and 14-19 parts of potentilla discolor.
Preferably, the compound medicament mainly comprises the following medicinal materials, by mass, 3 parts of pseudo-ginseng powder, 15 parts of salvia miltiorrhiza, 30 parts of astragalus membranaceus, 5 parts of ginseng, 30 parts of hawthorn, 15 parts of dandelion and 16 parts of potentilla discolor.
Preferably, the compound medicament can be used for preparing one of decoction, powder, capsules and pills.
Preferably, the preparation method of the decoction by using the compound medicament comprises the following steps:
according to the weight parts of the medicinal materials, pseudo-ginseng powder, salvia miltiorrhiza, astragalus mongholicus, ginseng, hawthorn, dandelion and discolor cinquefoil herb are selected and put into a medicine pot, 600-1000 parts of water is added, and the medicine pot is boiled under normal pressure 1 0-15min, decocting with slow fire for 10-20min, and filtering to obtain filtrate and residue;
adding 200-300 parts of water into the residue, boiling at normal pressure for 10-15min, decocting with slow fire for 10-20min, filtering to obtain filtrate and residue, and mixing the filtrate and residue to obtain decoction.
Preferably, the medicinal materials are crushed before being placed in a medicine pot, the crushed medicinal materials are crushed to 350-500 meshes, the crushed medicinal materials are placed in an ultraviolet box, and the ultraviolet box is placed for 10-30min for disinfection and sterilization.
Preferably, the medicinal materials are soaked before being put into a medicine pot, and are soaked for 25-40min after being soaked in cold water.
Preferably, the preparation method of the powder prepared from the composite medicament comprises the following steps:
according to the weight parts of the medicinal materials, the pseudo-ginseng powder, the red sage root, the astragalus root, the ginseng, the hawthorn, the dandelion and the discolor cinquefoil herb are sequentially put into an ultraviolet box for 10-30min for disinfection, then are sequentially dried, are crushed to be 100-200 meshes in particle size, and are uniformly mixed to obtain the powder.
Preferably, the preparation method of the capsule by using the compound medicament comprises the following steps:
according to the weight parts of the medicinal materials, the pseudo-ginseng powder, the red sage root, the astragalus root, the ginseng, the hawthorn, the dandelion and the discolor cinquefoil herb are sequentially put into an ultraviolet box for 10-30min for disinfection, then are sequentially dried, are crushed to the particle size of 100-200 meshes, are uniformly mixed, are equally divided into capsules, and are the capsules.
Preferably, the preparation method of the pill by adopting the compound medicament comprises the following steps:
according to the weight parts of the medicinal materials, the pseudo-ginseng powder, the salvia miltiorrhiza, the astragalus membranaceus, the ginseng, the hawthorn, the dandelion and the discolor cinquefoil herb are sequentially placed in an ultraviolet box for 10-30min to be disinfected, then are sequentially dried, are crushed to be 100-200 meshes in particle size, are sieved and mixed, are added with an adhesive, are heated and stirred uniformly, and are kneaded into balls to obtain pills;
preferably, the adhesive is one or a combination of water, honey, wine, vinegar and medicinal juice.
Preferably, the method for using the compound medicament comprises the following steps:
acupuncture with silver needle on Zusanli acupoints on both sides, and injection of compound Saviae Miltiorrhizae radix injection on Zusaze acupoints (both sides);
the medicine such as tanshinone, ligustrazine hydrochloride, vitamin B6 needle, etc. is used for transfusion;
after transfusion, the four limbs, the back and the abdomen are massaged, and simultaneously, the compound medicament is taken in the morning and at night every day.
In the experience of more than forty years of medical science, the applicant carries out continuous research, exploration and practice on pathogenesis and treatment of diabetes, summarizes a set of scientific, efficient, safe and mature medicine formula and treatment method for treating normal type 2 diabetes, and originally creates a set of ' Chen ' therapy ', which has the advantages of quick response, good effect, simplicity, convenience, practicability, safety, reliability, slight and rare side effect, and good curative effect on relieving the state of an illness, preventing and relieving complications or treating the complications, and the ' Chen Jicheng ' is reported by ' popular health ' in Beijing on 26 days 1 month in 2007: the ' type II diabetes mellitus ' is not a problem any more ' and is reported as a subject, the ' Chen ' treatment is reported in the ' Chinese medical research and inquiry ' (Beijing article) published in 2007 one month, and the ' Chinese invention and patent ' journal published in 2009, 6 and 20 days, and meanwhile, the ' Chen ' treatment ' is reported in the ' everybody health ' in 2016, 4 and 10 and 12 th periods, so that the ' Chen ' treatment ' breaks through the tradition and innovation theory and dares to be first, and a new path of diabetes mellitus ' is opened up ', and the ' Chen ' treatment ' is also publicized in the ' scientific journal ', the ' Chinese trade journal ', the ' rural medical science and literature ' and the ' Anhui ' science and technology journal '.
Compared with the prior art, the invention has at least the following advantages:
(1) The compound medicament provided by the invention is based on the principle of diabetes attack of traditional Chinese medicines, the medicine properties of the traditional Chinese medicines, the cooperation among the traditional Chinese medicines and the clinical experience of many years, the selected pseudo-ginseng powder, the red sage root and the hawthorn are used as monarch drugs to play roles of promoting blood circulation, removing blood stasis, expelling toxin, clearing heart, strengthening heart, tonifying qi and stimulating appetite, the selected astragalus and the dandelion are used as ministerial drugs to have the efficacies of clearing away heat and toxic materials, promoting the production of body fluid, nourishing blood, tonifying qi, invigorating yang, and consolidating constitution, the potentilla discolor is used as adjuvant drugs to prevent serious blood and qi leakage and play a role of stopping bleeding, and the ginseng is used as a conductant drug to play a role in harmonizing the medicinal materials.
(2) The compound medicament is matched with treatment methods such as infusion, acupuncture, massage and the like to restore the secretion function of islet cells of a patient, so that a better treatment effect can be achieved.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Example 1
The embodiment provides a method for treating diabetes, which combines a compound medicament with infusion, massage and acupuncture to achieve the treatment effect, and the specific operation comprises the following steps:
(1) Preparation of composite medicament
The compound medicament comprises the following medicinal materials in parts by weight: 3 parts of pseudo-ginseng powder, 15 parts of salvia miltiorrhiza, 30 parts of astragalus, 5 parts of ginseng, 30 parts of hawthorn, 15 parts of dandelion and 16 parts of potentilla discolor.
The preparation method for preparing the composite medicament into decoction comprises the following steps:
1) Selecting the medicinal materials according to the parts by weight, adding 800 parts of water into pseudo-ginseng powder, salvia miltiorrhiza, astragalus membranaceus, ginseng, hawthorn, dandelion and discolor cinquefoil herb, wherein the water is cold water, soaking in the cold water for 30min, then crushing, crushing to 400 meshes, putting into an ultraviolet box, placing for 20min for disinfection and sterilization, then putting into a medicine pot, adding cold water for soaking, boiling for 12min under normal pressure, continuing to boil for 15min with slow fire, and then filtering out medicine water and medicine residues;
2) Adding 250 parts of water into the medicinal liquid, boiling at normal pressure for 12min, decocting with slow fire for 15min, filtering to obtain medicinal liquid and residue, and mixing the medicinal liquids.
(2) Use of composite medicament
1) Acupuncture and moxibustion
Firstly, the acupuncture points of the two upper limbs and the acupuncture points of the two lower limbs are divided into Zusanli (two sides) three yin-crossing (two sides) and Neiguan (two sides) chi luster (two sides), and after the acupuncture, the needle is pulled up and is not left for a plurality of times;
2) Transfusion system
Intravenous infusion was performed in 3 groups, group 1: tanshinone 12 mg +250 ml 0.9% saline; group 2: ligustrazine hydrochloride 80 mg +250 ml of normal saline; group 3: vitamin B6 needle 4 ml +250 ml normal saline;
3) Massage device
The three points of epigastrium, epigastrium and epigastrium, guanyuan, qihai and Zhongji, huatuo Qianji, and the acupoints of pancreas, kidney, heart and gallbladder are sequentially massaged. The massage time is as follows: 2.5 minutes per acupoint on upper limb, 2.5 minutes per lower limb, 15 minutes on abdomen and 15 minutes on back, 40 minutes total;
4) Medicine drinking
The compound medicament prepared in the step (1) is divided into two parts and is taken after breakfast and supper.
The treatment course is 14 days, and the second course of consolidation treatment is carried out after 3-4 weeks after the first course of treatment is finished.
Example 2
The specific embodiment is the same as example 1, except for the preparation of the composite medicament in step (1);
in this embodiment, the compound medicament is selected to be prepared into powder, and the preparation method includes the following steps:
selecting pseudo-ginseng powder, salvia miltiorrhiza, astragalus membranaceus, ginseng, hawthorn, dandelion and discolor cinquefoil herb, sequentially putting the pseudo-ginseng powder, the salvia miltiorrhiza, the astragalus membranaceus, the ginseng, the hawthorn, the dandelion and the discolor cinquefoil herb into an ultraviolet box for disinfection for 10-30min, in the embodiment, selecting disinfection time for 20min, then sequentially drying, crushing to obtain particles with the particle size of 100-200 meshes, in the embodiment, selecting crushing to obtain particles with the particle size of 100 meshes, and uniformly mixing to obtain the powder.
Similarly, the powder is divided into two parts before use.
Example 3
The specific embodiment is the same as example 1, except for the preparation of the composite medicament in step (1);
in this embodiment, the compound preparation is selected to be prepared into a capsule, and the preparation method comprises the following steps:
sequentially placing Notoginseng radix powder, saviae Miltiorrhizae radix, radix astragali, ginseng radix, fructus crataegi, herba Taraxaci and herba Potentillae Discoloris in an ultraviolet box for 10-30min for sterilization, in this embodiment, selecting sterilization time of 20min, then sequentially oven drying, pulverizing to particle size of 100-200 mesh, in this embodiment, selecting pulverizing particle size of 100 mesh, mixing uniformly, equally dividing, and placing into capsule to obtain capsule.
Also, the number of capsules is selected to be two, and then used.
Example 4
The specific embodiment is the same as example 1, except for the preparation of the composite medicament in step (1);
in the embodiment, the compound medicament is selected to be prepared into pills, and the preparation method comprises the following steps:
sequentially placing Notoginseng radix powder, saviae Miltiorrhizae radix, radix astragali, ginseng radix, fructus crataegi, herba Taraxaci and herba Potentillae Discoloris in an ultraviolet box for 10-30min for sterilization, in this embodiment, selecting sterilization time to be 20min, then sequentially oven drying, pulverizing to particle size of 100-200 mesh, in this embodiment, selecting pulverized particle size of 100 mesh, sieving, mixing, adding binder, heating, stirring, kneading into spherical pill;
the adhesive is one or more of water, honey, wine, vinegar and medicinal liquid. In this example, the binder is selected to be a mixture of equal amounts of water and honey.
Also, the number of pills is selected to be two, and then used.
Examples 5 to 9
The specific embodiment is identical to example 1, except as indicated in table 1 below:
TABLE 1 influence of the ratio of the herbs on the therapeutic effect
Figure BDA0003935759720000071
Figure BDA0003935759720000081
Examples 10 to 11
The specific embodiment is identical to example 1, except as indicated in table 2 below:
TABLE 2 Effect of preparation conditions on the therapeutic Effect
Figure BDA0003935759720000082
Example 12
The specific embodiment is identical to example 1, with the only difference that only a combination of medicaments is administered.
Comparative example 1
The detailed description is identical to example 1, with the only difference that potentilla discolor is not used.
Comparative example 2
The specific embodiment is identical to example 1, with the only difference that no ginseng is used.
Experimental example 1
130 patients with type 2 diabetes were selected and treated by selecting the methods of examples 1 to 12 and comparative examples 1 to 2 every ten persons, and the treatment effect was judged by recording the index conditions of the patients after one treatment course and two treatment courses.
And (4) judging the standard:
and (4) invalidation: all the indexes of all the items of the body are not changed, and the blood sugar is not reduced;
the method has the following advantages: the indexes of all items of the body are obviously reduced, and the blood sugar is reduced;
the effect is shown: the indexes of all items of the body are recovered to be normal and the blood sugar is normal.
The results of the experiment are shown in table 3 below:
TABLE 3 analysis of the results of the efficacy of the experiments
Figure BDA0003935759720000091
Through the analysis of the results of the experimental example 1, the compound medicament of the invention has good curative effect in the treatment of type 2 diabetes, and has the advantages of low cost, quick response and good curative effect, meanwhile, the data of the example 12 shows that the compound reagent of the invention can also have good effect when being used alone, but the effect is better after combining acupuncture, massage and transfusion, and the compound medicament of the invention combines acupuncture, massage and transfusion to purposely promote the generation of islet cells and the secretion of insulin, thereby achieving the purpose of recovering the secretory function of the islet cells of a patient. It can be seen from the data of examples 4 and 6 that there are symptoms of ineffectiveness after treatment in individual patients, which are due to allergy to the drug or allergic symptoms of unknown origin, and thus poor treatment.
Meanwhile, it can be seen from the data of comparative example 1 that after potentilla discolor is lacked, the qi and blood of a patient are leaked due to the lack of adjuvant drugs, and the recovery effect of the patient is reduced, while in comparative example 2, the ginseng is lacked, the matching among the drugs is not good due to the lack of guiding drugs, and the treatment effect is far lower than that of example 1, so that the good treatment effect can be achieved only if the drugs of the present invention are mutually cooperated.
Experimental example 2
Ji Yi Chang, men, tang mountain ancient culture people, disease conditions: in 2004, the patient was admitted to the total hospital at day 11, 16 and 15 at a rate of 40 points from diabetes to Tangshan Kai 28390with a hospital admission number: 156237 And discharged at 22 days 11 months. Measuring the blood sugar of 30.1 hours after meal in Ringxi mine hospital one day before hospitalization, wherein the highest fasting blood sugar is 28.0, the lowest is 18.0, urine sugar + + +, urine ketone body + +, urine protein + +, during hospitalization period. Is diagnosed as type 2 diabetes. On day 11/21 of 2004, the patient called the applicant to consult for diabetes, and said that he did not want to stay in his hospital anymore and wanted to take insulin home himself. The applicant then asked him to try his treatment of diabetes here, and the patient was then hesitant to respond quickly to the fear of diabetes, say: "good, i will go to hospital to find you to treat" the next day, so, the patient will take two insulin and blood glucose meters with him after going out of the hospital in 2004, 11/22, and will find the applicant to treat directly without going home. When the patient is treated by the therapy, the patient needs to measure the blood sugar before each meal, and insulin is infused according to the blood sugar. After 8 times of treatment by the treatment method, namely more than 4 pm in 29 days, the patient self-tests the blood sugar for 4.4 and does not transfuse insulin at night. The next day, 11 months and 30 morning, the patient measured blood glucose on fasting, with a result of 5.2, normal. Measuring blood sugar at noon in 11 months and 30 days, and keeping normal; the blood sugar is measured at night in 11 months and 30 days, the blood sugar is normal (note: the patient stops infusing insulin during the measurement of the times), the patient has a rest for 10 days after being treated for 10 times in 12 months and 1 year 04 years, the patient has a rest for 10 days after being treated for 11 days and consolidated for 10 days in 12 months, the blood sugar index of the patient is kept normal until the current (9 months 2010), no insulin is infused, and no blood sugar-reducing medicine is taken.
Experimental example 3
Wang Mou, male, beijing, 37 years old, disease: the patient has a current diabetes history of 5 years, and usually takes 7 blood sugar-reducing medicines called 'Qingxueping capsule' orally, two medicines are taken 20 minutes before each meal, and one medicine is taken at 0 night. Blood sugar is maintained between 6 and 7. If the patient does not take the medicine, the fasting of the patient is maintained between 11 and 13. During the illness period, the patient had been treated in many top-grade hospitals such as the Zhongri friendly Hospital, the capital Hospital, the Beijing Hospital and the general air force Hospital in Beijing and rising to the sun in 2006 for 4 months. The patient had severe mental stress, dizziness, insomnia, blurred vision, chest distress, palpitation, and numbness of both legs. On day 16, 11/2006, the patient requested the applicant to go to Beijing for his treatment of diabetes. The following day of treatment with this therapy, the patient self-tests blood glucose 4.8! The patient starts to reduce the dosage of 1 particle of the 'Qingxueping capsule' every day, and the patient stops taking the 'Qingxueping capsule' medicine by himself or herself by the 8 th day. On the ninth day (24/11/2006), the patient self-tested 5.4 blood glucose on fasting in the morning. Thereafter, the patient is not orally administered any hypoglycemic agent, and fasting blood glucose is detected to be maintained between 5 and 6.5, and is substantially normal; no. 11-22 of No. 12 month 2006, the patient carries out the consolidation treatment of the 2 nd treatment course, after the 2 nd treatment course is finished, the symptoms of blurred vision and foreign body sensation of the eyes of the patient completely disappear, and the symptoms of dizziness, insomnia, amnesia, chest distress and palpitation also completely disappear! No. 3/5-No. 3/14 in 2007, and after the 3 rd treatment course is finished, the numbness symptoms of the two lower limbs disappear completely.
Finally, it is to be understood that the above embodiments are merely exemplary embodiments employed to illustrate the principles of the present invention, which is not limited thereto. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the principle and spirit of the invention, and such modifications and improvements are also considered to be within the scope of the invention.

Claims (10)

1. A compound medicament for treating diabetes is characterized by mainly comprising 1-5 parts of pseudo-ginseng powder, 10-20 parts of salvia miltiorrhiza, 20-40 parts of astragalus membranaceus, 1-8 parts of ginseng, 20-50 parts of hawthorn, 10-20 parts of dandelion and 12-20 parts of potentilla discolor.
2. The compound medicament of claim 1, which is mainly composed of, by mass, 2-4 parts of pseudo-ginseng powder, 12-17 parts of salvia miltiorrhiza, 28-34 parts of astragalus, 2-6 parts of ginseng, 28-40 parts of hawthorn, 12-18 parts of dandelion and 14-19 parts of potentilla discolor.
3. The compound medicament of claim 1, which is mainly composed of 3 parts of pseudo-ginseng powder, 15 parts of salvia miltiorrhiza, 30 parts of astragalus membranaceus, 5 parts of ginseng, 30 parts of hawthorn, 15 parts of dandelion and 16 parts of potentilla discolor.
4. The composite pharmaceutical preparation according to any one of claims 1 to 3, which is used for preparing one of a decoction, a powder, a capsule and a pill.
5. The compound medicament as claimed in claim 4, wherein the preparation method of the decoction comprises the following steps:
according to the weight parts of the medicinal materials, selecting pseudo-ginseng powder, salvia miltiorrhiza, astragalus membranaceus, ginseng, hawthorn, dandelion and discolor cinquefoil herb, putting the pseudo-ginseng powder, the salvia miltiorrhiza, the astragalus membranaceus, the ginseng, the hawthorn, the dandelion and the discolor cinquefoil herb into a medicinal pot, adding 600-1000 parts of water, boiling for 10-15min under normal pressure, then continuously boiling for 10-20min with slow fire, and filtering out medicinal water and filter residues;
adding 200-300 parts of water into the residue, boiling at normal pressure for 10-15min, decocting with slow fire for 10-20min, filtering to obtain filtrate and residue, and mixing the filtrate and residue to obtain decoction.
6. The compound medicament of claim 5, wherein the medicinal materials are pulverized before being placed in a pot, and are pulverized to 350-500 mesh, and the pulverized medicinal materials are placed in an ultraviolet box, and are placed for 10-30min for sterilization.
7. The compound medicament of claim 5, wherein the medicinal materials are soaked before being put into a pot, and the medicinal materials are soaked for 25-40min after being soaked in cold water.
8. The composite medicament of claim 4, wherein the powder is prepared by a method comprising the steps of:
according to the weight parts of the medicinal materials, the pseudo-ginseng powder, the salvia miltiorrhiza, the astragalus membranaceus, the ginseng, the hawthorn, the dandelion and the discolor cinquefoil herb are sequentially placed in an ultraviolet box for 10-30min to be disinfected, then are sequentially dried, are crushed to be 100-200 meshes in diameter, and are uniformly mixed to obtain the powder.
9. The composite medicament of claim 4, wherein the preparation method of the capsule comprises the following steps:
according to the weight parts of the medicinal materials, the pseudo-ginseng powder, the salvia miltiorrhiza, the astragalus membranaceus, the ginseng, the hawthorn, the dandelion and the discolor cinquefoil herb are sequentially placed in an ultraviolet box for 10-30min to be disinfected, then are sequentially dried, are crushed to be 100-200 meshes in size, are uniformly mixed, are equally divided and are placed in a capsule, and the capsule is obtained.
10. The composite medicament of claim 4, wherein the preparation method of the pill comprises the following steps:
according to the weight parts of the medicinal materials, the pseudo-ginseng powder, the salvia miltiorrhiza, the astragalus membranaceus, the ginseng, the hawthorn, the dandelion and the discolor cinquefoil herb are sequentially placed in an ultraviolet box for 10-30min to be disinfected, then are sequentially dried, are crushed to be 100-200 meshes in particle size, are sieved and mixed, are added with an adhesive, are heated and stirred uniformly, and are kneaded into balls to obtain pills;
preferably, the adhesive is one or a combination of water, honey, wine, vinegar and medicinal juice.
CN202211403780.5A 2022-11-10 2022-11-10 Compound medicament for treating diabetes Pending CN115554341A (en)

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