CN115109697A - Temperature control all-in-one machine for detection - Google Patents
Temperature control all-in-one machine for detection Download PDFInfo
- Publication number
- CN115109697A CN115109697A CN202211048375.6A CN202211048375A CN115109697A CN 115109697 A CN115109697 A CN 115109697A CN 202211048375 A CN202211048375 A CN 202211048375A CN 115109697 A CN115109697 A CN 115109697A
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- temperature control
- module
- plate
- shell
- detection
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- 238000001514 detection method Methods 0.000 title claims abstract description 28
- 229910000838 Al alloy Inorganic materials 0.000 claims description 19
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 229910002804 graphite Inorganic materials 0.000 claims description 4
- 239000010439 graphite Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 9
- 239000007788 liquid Substances 0.000 description 7
- 238000012546 transfer Methods 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- 230000005389 magnetism Effects 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010944 pre-mature reactiony Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
Abstract
The invention discloses a temperature control all-in-one machine for detection, and relates to the field of experimental equipment. The temperature control all-in-one machine for detection comprises a shell; the centrifugal tube module is arranged on the shell and comprises a plurality of types of centrifugal tube grooves, centrifugal tubes are placed in the centrifugal tube grooves, and the centrifugal tube module also comprises a first temperature control module which is arranged in the shell and positioned below the centrifugal tube grooves; the deep hole plate module is arranged on the shell and positioned on one side of the centrifuge tube temperature changing module, and comprises a deep hole plate frame and a second temperature control module which is arranged in the shell and positioned below the deep hole plate frame; and the PCR plate module is arranged on the shell and comprises a PCR plate and a third temperature control module arranged inside the shell and positioned below the PCR plate.
Description
Technical Field
The invention belongs to the field of experimental equipment, and particularly relates to a temperature control all-in-one machine for detection.
Background
Based on the diversity of the current biochemical research, the requirements on the experimental operation environment are higher and higher, a plurality of experimental samples can react at normal temperature, and after an experimenter adds the samples on a workbench or takes out the samples from a refrigerated cabinet, the samples can be exposed at the normal temperature environment, and the conditions of premature reaction or deterioration and the like can occur, so that the originality of the samples can be damaged, the experimental detection data can be influenced, and the precision of the detection result can be reduced; and if another temperature is needed during the reaction, the reaction kettle is put into a specific container for temperature adjustment, so that the experimental efficiency is reduced, and the economic cost is increased.
Disclosure of Invention
The invention provides a temperature control all-in-one machine for detection, which can regulate and control temperature.
In order to solve the technical problems, the invention provides the following technical scheme:
a temperature control integrated machine for detection comprises a shell; the centrifugal tube module is arranged on the shell and comprises a plurality of types of centrifugal tube grooves, centrifugal tubes are placed in the centrifugal tube grooves, and the centrifugal tube module also comprises a first temperature control module which is arranged in the shell and is positioned below the centrifugal tube grooves; the deep hole plate module is arranged on the shell and positioned on one side of the centrifuge tube temperature changing module, and comprises a deep hole plate frame and a second temperature control module which is arranged in the shell and positioned below the deep hole plate frame; and the PCR plate module is arranged on the shell and comprises a PCR plate and a third temperature control module arranged inside the shell and positioned below the PCR plate.
Further, the first temperature control module comprises a temperature control plate, and a radiating fin is arranged below the temperature control plate and is in contact with the bottom of the shell.
Further, the top of control by temperature change board is provided with aluminium alloy plate, aluminium alloy plate's upper surface is provided with a plurality of recesses, be provided with a plurality of first magnets in the recess, aluminium alloy plate's upper end be provided with centrifuging tube groove matched with recess board, the below of recess board is provided with second magnet, first magnet with second magnet is opposite sex.
Further, the second temperature control module and/or the third temperature control module have the same structure as the first temperature control module.
Further, between control by temperature change board and the fin, between control by temperature change board and the aluminium alloy plate and all be provided with heat-conducting medium between aluminium alloy plate and the recess board.
Further, the heat-conducting medium is made of heat-conducting graphite sheets.
Furthermore, both sides of the housing are provided with a fan and a vent hole.
Furthermore, a detect and use control by temperature change all-in-one, still include move liquid module, set up on the casing, move liquid module including setting up a plurality of liquid-transfering guns in the casing top.
Furthermore, a display screen is further arranged on the shell.
Furthermore, a plurality of foot seats are arranged below the shell.
Compared with the prior art, the invention has the following beneficial effects:
the invention relates to a temperature control integrated machine for detection, which comprises a centrifuge tube module, a deep hole plate module and a PCR plate module, wherein the centrifuge tube module, the deep hole plate module and the PCR plate module are arranged on a shell and are used for providing a space for storing and reacting samples, the reaction samples are transferred in different modules according to the detection requirement of an experiment, the centrifuge tube module is used for placing original samples, the deep hole plate module is used for carrying out proportioning reaction on the samples transferred from different centrifuge tubes, and the PCR plate module is used for storing reactants extracted from the deep hole plate to complete the reading of the experimental result; all modules are matched with each other to complete the whole reaction step; respectively at the centrifuging tube module, deep hole board module and PCR board module below are provided with solitary temperature control module, can adjust the required real-time temperature of every module alone, come nimble control to place the temperature of sample and sample reaction, avoid reagent to react in advance under the normal atmospheric temperature and influence ultimate experimental result, reduce the sample simultaneously and deposit and change the frequency of container because of needing different temperature environment with the reaction time. The invention has simple structure, can improve the experiment precision and the experiment efficiency, simultaneously reduces the use of experiment appliances and controls the experiment cost.
Drawings
FIG. 1 is a top view of a temperature control integrated machine for detection according to the present invention.
FIG. 2 is a front view of a temperature control integrated machine for detection according to the present invention.
Fig. 3 is a structural diagram of a first temperature control module of the integrated temperature control machine for detection according to the present invention.
In the figure: 1 casing, 2 centrifugal tube grooves, 3 centrifuging tubes, 4 deep-hole grillages, 5PCR boards, 6 control by temperature change boards, 7 fin, 8 aluminum alloy plate, 9 first magnet, 10 recess boards, 11 second magnet, 12 heat-conducting medium, 13 fans, 14 ventilation holes, 15 liquid-transfering gun, 16 display screens, 17 footstands.
Detailed Description
In order to make the technical problems, technical solutions and advantages of the present invention more apparent, the following detailed description is given with reference to the accompanying drawings and specific embodiments.
The invention provides a temperature control all-in-one machine for detection, which comprises a shell 1, a temperature control unit and a temperature control unit, wherein the temperature control all-in-one machine is shown in figures 1-3; the centrifugal tube module is arranged on the shell 1 and comprises a plurality of types of centrifugal tube grooves 2, centrifugal tubes 3 are placed in the centrifugal tube grooves 2, and the centrifugal tube module also comprises a first temperature control module which is arranged in the shell 1 and is positioned below the centrifugal tube grooves 2; the deep hole plate module is arranged on one side of the centrifugal pipe module on the shell 1 and comprises a deep hole plate frame 4 and a second temperature control module which is arranged in the shell 1 and is positioned below the deep hole plate frame 4; and the PCR plate module is arranged on the shell 1 and comprises a PCR plate 5 and a third temperature control module arranged inside the shell 1 and positioned below the PCR plate 5.
Furthermore, the deep-hole plate frame is used for placing a deep-hole plate.
The invention relates to a temperature control integrated machine for detection, which comprises a centrifuge tube 3 module, a deep hole plate module and a PCR plate 5 module which are arranged on a shell 1, wherein the centrifuge tube 3 module, the deep hole plate module and the PCR plate 5 module are used for providing a space for storing and reacting a reaction sample, the reaction sample is transferred among different modules according to the experimental detection requirement, the centrifuge tube 3 module is used for placing an original sample, the deep hole plate module is used for carrying out proportioning reaction on the sample transferred from different centrifuge tubes 3, and the PCR plate 5 module is used for storing a reactant extracted from the deep hole plate to complete the reading of the experimental result; all modules are matched with each other to complete the whole reaction step; respectively at 3 modules of centrifuging tube, deep-hole board module and 5 module below of PCR board are provided with solitary temperature control module, can adjust the required real-time temperature of every module alone, come nimble control to place the temperature of sample and sample reaction, avoid reagent to react in advance under the normal atmospheric temperature and influence final experimental result, reduce the sample simultaneously and deposit and the reaction because of the frequency that needs different temperature environment and change the container. The invention has simple structure, can improve the experiment precision and the experiment efficiency, simultaneously reduces the use of experiment appliances and controls the experiment cost.
Further, first temperature control module includes temperature control board 6, and temperature control board 6 chooses for use the paler subsides, and the below of temperature control board 6 can set up fin 7, fin 7 with the bottom of casing 1 contacts, and fin 7 can be sparse with the unnecessary heat that produces when temperature control board 6 heats and the heat of conversion when refrigerating, prevents that the heat from piling up and causing the temperature control all-in-one machine for detection to generate heat, influences the temperature control effect.
Further, can set up aluminium alloy plate 8 in the top of control by temperature change board 6, be used for installing first magnet 9 through being provided with a plurality of recesses at aluminium alloy plate 8's upper surface to be provided with in aluminium alloy plate 8's upper end with 2 matched with recess boards of centrifugal tube groove 10, through being provided with second magnet 11 in recess board 10's below, first magnet 9 and second magnet 11 are opposite sex, so aluminium alloy plate 8 and recess board 10 can be closed together through the suction of magnetism. Make the shape with the bottom surface matched with of centrifugation tube seat 2 through the upper surface with recess board 10, so recess board 10 can contact with the 2 bottom maximum areas of centrifugation tube seat to recess board 10 can adopt the aluminum alloy to make, has good heat conductivility, can be faster transmits the temperature of temperature control plate 6 to centrifugation tube seat 2.
In an embodiment of the invention, the second temperature control module and/or the third temperature control module has the same structure as the first temperature control module, the second temperature control module is arranged inside the casing 1 and below the deep-hole plate frame 4, the groove plate 10 in the second temperature control module is matched with the bottom surface of the deep-hole plate frame 4, so that the temperature of the temperature control plate 6 can be quickly transferred to the deep-hole plate frame 4, and the rest structures are uniform and the same as the first temperature control module; the setting of third temperature control module is in the inside below that is located PCR board 5 of casing 1, and recess board 10 in the third temperature control module cooperatees with PCR board 5's bottom surface, can be very fast transmit PCR board 5 with the temperature of temperature control board 6, and all the other even above-mentioned first temperature control modules of structure are the same, and because recess board 10 in above-mentioned each temperature control module is connected for magnetism with aluminium alloy plate, be convenient for change, the structure is the same except that recess board 10, the batch production of being convenient for.
Further, can be between control by temperature change board 6 and fin 7, all set up heat-conducting medium 12 between control by temperature change board 6 and the aluminium alloy plate 8 and between aluminium alloy plate 8 and the recess board 10, when because the plate direct contact is fixed, because the plate has certain machining error, can have the gap between the plate, the gap can reduce heat conduction efficiency, the influence detects the control by temperature change effect with control by temperature change all-in-one, through setting up heat-conducting medium 12, both filled the gap between the plate, again because the good heat conductivility of heat-conducting medium 12 itself promotes the high-efficient transfer of heat.
Preferably, the heat-conducting medium 12 is a heat-conducting graphite sheet, and the heat-conducting graphite sheet is a solid medium, so that the operation of a processing personnel is facilitated compared with a liquid medium.
In an embodiment of the present invention, the fan 13 and the vent hole 14 may be disposed on two sides of the housing 1, and the technical scheme has two implementation manners, one is to respectively dispose the fan 13 and the vent hole 14 on the left and right sides of the housing 1 to implement lateral ventilation, and to transport heat dissipated by the heat sink 7 to the outside through the vent hole 14; another implementation is that the fan 13 and the vent hole 14 are respectively arranged at the front side and the rear side in the shell 1 and at the positions corresponding to the centrifugal tube module, the deep hole plate module and the PCR plate module, each module is provided with an independent ventilation device, so that heat can be better guaranteed to be timely and thoroughly conveyed to the outside from the shell 1, and heat accumulation in the shell 1 is avoided.
Furthermore, the temperature control integrated machine for detection also comprises a liquid transfer module arranged on the shell, wherein the liquid transfer module mainly comprises a plurality of liquid transfer guns 15 arranged above the shell, and the liquid transfer guns 15 are used for sucking and transferring reagent samples among different modules, so that the integrated operation of experimenters is facilitated.
Further, can set up display screen 16 on casing 1, be connected with temperature control system through display screen 16, can more audio-visual demonstration and control the temperature, make things convenient for experimenter's use.
As can be understood by those skilled in the art, a plurality of foot seats 17 can be arranged below the shell 1 to realize fixed support of the shell 1, the support effect of the foot seats 17 is more stable than that of the bottom surface directly placed on an operating table, and meanwhile, direct abrasion to the shell 1 can be reduced.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. The utility model provides a detect and use temperature control all-in-one which characterized in that includes:
a housing;
the centrifugal tube module is arranged on the shell and comprises a plurality of types of centrifugal tube grooves, centrifugal tubes are placed in the centrifugal tube grooves, and the centrifugal tube module also comprises a first temperature control module which is arranged in the shell and is positioned below the centrifugal tube grooves;
the deep hole plate module is arranged on the shell and positioned on one side of the centrifuge tube temperature changing module, and comprises a deep hole plate frame and a second temperature control module which is arranged in the shell and positioned below the deep hole plate frame;
and the PCR plate module is arranged on the shell and comprises a PCR plate and a third temperature control module arranged inside the shell and positioned below the PCR plate.
2. The integrated temperature control machine for detection according to claim 1, wherein the first temperature control module comprises a temperature control plate, a heat sink is arranged at the lower end of the temperature control plate, and the heat sink is in contact with the bottom of the shell.
3. The integrated temperature control machine for detection according to claim 2, wherein an aluminum alloy plate is arranged at the upper end of the temperature control plate, a plurality of grooves are formed in the upper surface of the aluminum alloy plate, a plurality of first magnets are arranged in the grooves, a groove plate matched with the centrifuge tube grooves is arranged at the upper end of the aluminum alloy plate, a second magnet is arranged below the groove plate, and the first magnet and the second magnet are opposite in nature.
4. The integrated temperature control machine for detection as claimed in claim 3, wherein the second temperature control module and/or the third temperature control module has the same structure as the first temperature control module.
5. The integrated temperature and temperature controller for detection of claim 3, wherein heat conducting media are arranged between the temperature control plate and the heat sink, between the temperature control plate and the aluminum alloy plate, and between the aluminum alloy plate and the groove plate.
6. The integrated temperature control machine for detection according to claim 5, wherein the heat-conducting medium is a heat-conducting graphite sheet.
7. The integrated temperature control machine for detection as claimed in claim 1, wherein fans and vents are provided at both sides of the housing.
8. The integrated temperature control machine for detection according to claim 1, further comprising a pipetting module disposed on the housing, wherein the pipetting module comprises a plurality of pipetting guns disposed above the housing.
9. The integrated temperature control machine for detection as claimed in claim 1, wherein a display screen is further arranged on the housing.
10. The integrated temperature control machine for detection as claimed in claim 1, wherein a plurality of foot seats are arranged below the shell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211048375.6A CN115109697A (en) | 2022-08-30 | 2022-08-30 | Temperature control all-in-one machine for detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211048375.6A CN115109697A (en) | 2022-08-30 | 2022-08-30 | Temperature control all-in-one machine for detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115109697A true CN115109697A (en) | 2022-09-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211048375.6A Pending CN115109697A (en) | 2022-08-30 | 2022-08-30 | Temperature control all-in-one machine for detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115109697A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5739031B1 (en) * | 2014-03-04 | 2015-06-24 | 株式会社テクノスヤシマ | Culture box |
| CN109337793A (en) * | 2018-10-23 | 2019-02-15 | 宁波艾捷康宁生物科技有限公司 | A kind of full-automatic nucleic acid extraction detection system |
| US20200055053A1 (en) * | 2018-08-14 | 2020-02-20 | Digital Biosystems | Apparatuses and Methods for Operating a Digital Microfluidic Device |
| CN111013688A (en) * | 2019-12-06 | 2020-04-17 | 深圳市刚竹医疗科技有限公司 | qPCR module and modularized qPCR device |
-
2022
- 2022-08-30 CN CN202211048375.6A patent/CN115109697A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5739031B1 (en) * | 2014-03-04 | 2015-06-24 | 株式会社テクノスヤシマ | Culture box |
| US20200055053A1 (en) * | 2018-08-14 | 2020-02-20 | Digital Biosystems | Apparatuses and Methods for Operating a Digital Microfluidic Device |
| CN109337793A (en) * | 2018-10-23 | 2019-02-15 | 宁波艾捷康宁生物科技有限公司 | A kind of full-automatic nucleic acid extraction detection system |
| CN111013688A (en) * | 2019-12-06 | 2020-04-17 | 深圳市刚竹医疗科技有限公司 | qPCR module and modularized qPCR device |
Non-Patent Citations (2)
| Title |
|---|
| MATTHEW D. ESTES ET AL.: "Optimization of multiplexed PCR on an integrated microfluidic forensic platform for rapid DNA analysis", 《ANALYST》 * |
| 雷祝兵等: "快速变温的帕尔贴元件PCR温控模块设计", 《新器件新技术》 * |
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Application publication date: 20220927 |