CN112859953A - Temperature control module in biological reaction instrument - Google Patents
Temperature control module in biological reaction instrument Download PDFInfo
- Publication number
- CN112859953A CN112859953A CN202110021316.9A CN202110021316A CN112859953A CN 112859953 A CN112859953 A CN 112859953A CN 202110021316 A CN202110021316 A CN 202110021316A CN 112859953 A CN112859953 A CN 112859953A
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- Prior art keywords
- temperature control
- control module
- upper cover
- temperature
- biological reaction
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 33
- 238000012546 transfer Methods 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims description 11
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 3
- 239000011859 microparticle Substances 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 230000007704 transition Effects 0.000 claims 1
- 238000005842 biochemical reaction Methods 0.000 abstract description 5
- 238000012545 processing Methods 0.000 abstract description 5
- 230000033228 biological regulation Effects 0.000 abstract description 3
- 230000035484 reaction time Effects 0.000 abstract description 3
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000017525 heat dissipation Effects 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
- G05D23/20—Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature
Abstract
The invention provides a temperature control module in a biological reaction instrument, which comprises a flat plate and an upper cover, wherein the upper cover and the flat plate are oppositely arranged and are connected into a whole, a plurality of container holes for placing reaction consumables are formed in the upper cover, one side of the upper cover, which faces to the flat plate, is provided with accommodating cavities between any two adjacent container holes, the accommodating cavities are communicated with each other, and phase-change heat transfer media are filled in the accommodating cavities. The invention adopts the phase-change heat transfer medium, so that the temperature rise and fall speed is accelerated, the temperature uniformity of the temperature control module in the biological reaction instrument can be obviously improved, the biochemical reaction time can be shortened, and the structure in the prior art is not adopted any more, so that the temperature regulation performance of the temperature control module in the biological reaction instrument does not excessively depend on the processing and assembling precision of related parts, and further the reliability of the module is improved.
Description
Technical Field
The invention belongs to the technical field of chemical biological reaction instruments, and particularly relates to a temperature control module in a biological reaction instrument.
Background
The accurate temperature control performance is the necessary condition for reagent preservation and experiment operation related to biochemical reaction at present. At present, many kinds of instruments have biochemical reaction temperature control function, can be widely used in various enzymatic reactions and the preservation of biological samples, reaction reagents, such as polymerase chain reaction analyzer, constant temperature amplification appearance, solution curve appearance etc. the temperature control module in the biological reaction instrument in this kind of instrument, the fixed mode of "sandwich" form is adopted to structural the majority, includes to both ends by the centre: go up and down temperature part, heat conduction gasket, accuse temperature metal block, radiator etc. the radiator is the forced air cooling heat dissipation mostly, and a small number has the circulation liquid cooling heat dissipation, and the temperature control metal block is used for the hole that the cooperation reaction consumptive material (reaction tube or reaction plate) was made in the processing on the monoblock entity metal (mostly using copper, aluminium as main, a small number uses silver) mostly.
The instrument with the structure has the defects of long overall experiment running time caused by slow temperature rise and fall speed, uneven heat distribution caused by material performance and structural limitation, poor consistency among experimental result holes and the like in the aspect of temperature control performance. Particularly for a real-time fluorescent quantitative PCR instrument, a conventional PCR reaction needs more than 40 PCR cycles, and a plurality of processes such as rapid temperature rise and fall, accurate temperature control (including performances such as accurate temperature, accurate temperature control time and the like), rapid fluorescent signal acquisition and the like are involved in each cycle.
The temperature control module in the biological reaction instrument with the structure has low temperature rise and fall rate, so that each cycle needs to go through a long process to reach the preset temperature, and a plurality of cycles are accumulated, so that the whole experimental process is frequently carried out for 1-2 hours, and for medical application, research and development of rapid reaction reagents and marketing, higher and higher requirements are provided for the temperature rise and fall rate of the instrument.
A heat conducting cushion layer is usually arranged between the temperature rising and reducing component and the temperature control metal block and used for eliminating a gap between the heating component and the heating component, so that the heating component and the heating component are in full contact, heat transfer is more uniform, heat conducting silicone grease, heat conducting glue, a heat conducting carbon film and the like are usually used, the heat conducting coefficient of the materials is not high, the materials are aged after being used for a long time, and the heat conducting effect is reduced. The temperature control metal block is used as a heat transmission intermediate layer to finally transmit heat to the reaction consumable material, and the capacity of self-regulating heat transmission uniformity is not provided. Therefore, the temperature accuracy performance of the temperature control module in the whole biological reaction instrument is finally determined by the following factors: the heat conduction capability, structure and processing precision of the temperature control metal block material; the assembly precision of the temperature control module in the whole biological reaction instrument of the instrument; the temperature control capacity of the plurality of temperature increasing and decreasing components is coordinated with each other.
Disclosure of Invention
Therefore, the technical problem to be solved by the present invention is to provide a temperature control module in a biological reaction apparatus, which can solve the technical problem of at least one aspect proposed above.
In order to solve the above problems, the present invention provides a temperature control module in a bioreactor apparatus, comprising a flat plate and an upper cover, wherein the upper cover and the flat plate are oppositely arranged and connected into a whole, the upper cover is configured with a plurality of container holes for placing reaction consumables, a containing cavity is formed between any two adjacent container holes on one side of the upper cover facing the flat plate, the containing cavities are communicated with each other, and the containing cavity is filled with a phase change heat transfer medium.
Preferably, the upper cover comprises a main plate body and side standing walls arranged around the main plate body, the plurality of container holes are formed in the main plate body and extend along one side facing the flat plate, and one side of each side standing wall, which is far away from the main plate body, is in sealing connection with the flat plate; and/or the bottom wall of the container hole is in contact connection with the flat plate.
Preferably, the wall of the containing cavity is provided with a capillary structure adhesion layer.
Preferably, the capillary structure attachment layer is formed by a plurality of microparticles arranged adjacently.
Preferably, the capillary structure adhesion layer (4) is composed of fine channels or grooves.
Preferably, the wall of the container hole is made of a material with high thermal conductivity coefficient, and the high thermal conductivity coefficient is that the thermal conductivity coefficient is not less than 10W/m.K.
Preferably, the high thermal conductivity material comprises one or a combination of copper, aluminum, silver.
Preferably, the temperature control module in the bioreactor apparatus further comprises a micro tube, the micro tube is communicated with the accommodating cavity, and a vacuum environment can be formed in the accommodating cavity through the micro tube and the phase-change heat transfer medium can be filled in the accommodating cavity.
Preferably, the upper cover is further configured with a temperature sensor mounting structure.
Preferably, the container hole is a tapered hole, and the orifice diameter of the tapered hole is larger than the hole bottom diameter.
According to the temperature control module in the biological reaction instrument, the temperature rise and fall speed is accelerated due to the adoption of the phase-change heat transfer medium, the temperature uniformity of the temperature control module in the biological reaction instrument can be remarkably improved, the biochemical reaction time can be shortened, and the temperature regulation performance of the temperature control module in the biological reaction instrument does not depend on the processing and assembling precision of related parts due to the fact that the structure in the prior art is not adopted any more, so that the reliability of the module is improved.
Drawings
FIG. 1 is a schematic perspective view of a temperature control module in a bioreactor apparatus according to an embodiment of the present invention;
FIG. 2 is a perspective view of FIG. 1 from another perspective;
FIG. 3 is a schematic (partial) internal view of the structure of FIG. 1;
FIG. 4 is a schematic view of the internal structure of FIG. 1 (with the main plate hidden);
fig. 5 is a schematic structural view of the phase change heat transfer medium in a liquid phase state.
The reference numerals are represented as:
1. a flat plate; 2. an upper cover; 21. a container aperture; 22. an accommodating chamber; 23. a main board body; 24. a side standing wall; 25. a temperature sensor mounting structure; 3. a phase change heat transfer medium; 4. a capillary structure attachment layer; 5. a microtube.
Detailed Description
Referring to fig. 1 to 5 in combination, according to an embodiment of the present invention, there is provided a temperature control module in a bioreactor apparatus, including a plate 1 and an upper cover 2, where the upper cover 2 and the plate 1 are oppositely arranged and connected into a whole, the upper cover 2 is configured with a plurality of container holes 21 for placing reaction consumables, a containing cavity 22 is formed between any two adjacent container holes 21 on one side of the upper cover 2 facing the plate 1, and the containing cavities 22 are communicated with each other, and the containing cavity 22 is filled with a phase-change heat transfer medium 3. In the technical scheme, the accommodating cavity 22 is filled with the phase-change heat transfer medium 3, when the temperature control module in the biological reaction instrument is locally heated by a heat source, the liquid phase-change heat transfer medium 3 in the containing cavity 22, which is close to the heat source area, is heated and quickly gasified, the liquid state is evaporated to be in a gaseous state to absorb a large amount of heat energy, the volume is quickly expanded, the gaseous medium quickly fills the whole containing cavity 22, when the gas phase medium contacts a relatively cold area in the cavity, condensation liquefaction is generated, heat accumulated in evaporation is released through the condensation process, the condensed phase-change heat transfer medium 3 flows back to the heat source area, the process is repeated in the accommodating cavity 22, so that the heat generated by the heat source area is rapidly transmitted to the whole temperature control module in a state of not having time to be locally accumulated, and the effect of uniform temperature is achieved. That is, the temperature rise and fall speed is accelerated by adopting the phase-change heat transfer medium 3 in the technical scheme of the invention, the temperature uniformity of the temperature control module in the biological reaction instrument can be obviously improved, the biochemical reaction time can be shortened, and the structure in the prior art is not adopted any more, so that the temperature regulation performance of the temperature control module in the biological reaction instrument does not excessively depend on the processing and assembling precision of related parts, and further the reliability of the module is improved.
As a specific embodiment of the upper cover 2, preferably, the upper cover 2 includes a main plate 23 and a side standing wall 24 disposed around the main plate 23, a plurality of the container holes 21 are configured on the main plate 23 and extend along a side facing the flat plate 1, a side of the side standing wall 24 away from the main plate 23 is connected with the flat plate 1 in a sealing manner, that is, the side standing wall 24 forms an outer edge of the accommodating cavity 22 formed between the upper cover 2 and the flat plate 1, further, a hole bottom wall of the container hole 21 is connected with the flat plate 1 in a contact manner, for example, the hole bottom wall of the container hole 21 is connected with a contact surface of the flat plate 1 in a welding manner, and similarly, the side standing wall 24 and the contact surface of the flat plate 1 can also be connected in a welding manner, so that the upper cover 2 and the flat plate 1 form an organic whole, this facilitates uniform conduction of temperature.
In some embodiments, the cavity wall of the accommodating cavity 22 has a capillary structure adhesion layer 4 thereon, specifically for example, the capillary structure adhesion layer 4 is formed by disposing a plurality of microparticles adjacently, so as to form a backflow channel of the phase-change heat transfer medium 3 on the cavity wall of the accommodating cavity 22, thereby facilitating the circulation of the phase-change heat transfer medium 3 in the liquid phase-gas phase in the accommodating cavity 22. Specifically, the wall of the accommodating cavity 22 includes a wall structure of the upper cover 2 corresponding to the flat plate 1 and the accommodating cavity 22.
Preferably, the wall of the container hole 21 is made of a high thermal conductivity metal, which includes one of copper, aluminum, and silver, and this can improve the conduction of heat in the phase change heat transfer medium 3 in the accommodating cavity 22 to the reaction consumable in the container hole 21.
In some embodiments, the temperature control module in the bioreactor apparatus further includes a micro tube 5 (i.e., a tube with a small diameter), the micro tube 5 is in communication with the accommodating cavity 22, and the accommodating cavity 22 can be formed with a vacuum environment and filled with the phase-change heat transfer medium 3 through the micro tube 5, but it is understood that after the formation of the vacuum environment of the accommodating cavity 22 and the filling of the phase-change heat transfer medium 3 are completed, the micro tube 5 should be subjected to a plugging process to isolate the communication between the accommodating cavity 22 and the external environment, ensure the vacuum degree in the accommodating cavity 22, and configure the inside of the accommodating cavity 22 into the vacuum environment, which can significantly improve the heat transfer efficiency.
The upper cover 2 is further provided with a temperature sensor mounting structure 25 for mounting a temperature sensor to realize accurate detection and adjustment of temperature, and the temperature sensor mounting structure 25 may be a hole or groove structure, and may be matched with a specific structural form of the temperature sensor.
The container hole 21 is a tapered hole, and the diameter of the opening of the tapered hole is larger than that of the bottom of the hole, so that the reaction consumables can be placed in the container hole 21 conveniently.
It is readily understood by a person skilled in the art that the advantageous ways described above can be freely combined, superimposed without conflict.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention. The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several improvements and modifications can be made without departing from the technical principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.
Claims (10)
1. The utility model provides a accuse temperature module among bioreactor instrument, its characterized in that, includes dull and stereotyped (1) and upper cover (2), upper cover (2) with dull and stereotyped (1) mutual disposition and connect as an organic wholely, be constructed a plurality of container hole (21) that are used for placing the reaction consumptive material on upper cover (2) orientation one side of dull and stereotyped (1), form between two arbitrary adjacent container hole (21) and hold chamber (22), and each holds chamber (22) and communicate each other, it has phase transition heat transfer medium (3) to fill in chamber (22).
2. The temperature control module of claim 1, wherein the upper cover (2) comprises a main plate (23) and a side standing wall (24) surrounding the main plate (23), a plurality of container holes (21) are formed in the main plate (23) and extend along one side facing the plate (1), and one side of the side standing wall (24) far away from the main plate (23) is connected with the plate (1) in a sealing manner; and/or the contact connection between the bottom wall of the container hole (21) and the flat plate (1).
3. The temperature control module of claim 1, wherein the holding chamber (22) has a capillary structure adhesion layer (4) on the wall.
4. The temperature control module of claim 3, wherein the capillary structure adhesion layer (4) is formed by a plurality of microparticles arranged adjacently.
5. The temperature control module in a biological reaction instrument according to claim 3, wherein the capillary structure adhesion layer (4) is composed of fine channels or grooves.
6. The temperature control module of claim 1, wherein the wall of the container hole (21) is made of a material with high thermal conductivity, and the high thermal conductivity is not less than 10W/m.K.
7. The temperature control module of claim 6, wherein the high thermal conductivity material comprises one or a combination of copper, aluminum and silver.
8. The temperature control module in a bioreactor apparatus according to claim 1, further comprising a micro tube (5), wherein the micro tube (5) is communicated with the accommodating chamber (22) so as to form a vacuum environment for the accommodating chamber (22) through the micro tube (5) and fill the phase-change heat transfer medium (3).
9. The temperature control module in a biological reaction instrument according to claim 1, wherein the upper cover (2) is further constructed with a temperature sensor mounting structure (25).
10. The temperature control module of claim 1, wherein the container hole (21) is a tapered hole, and the diameter of the opening of the tapered hole is larger than the diameter of the bottom of the hole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110021316.9A CN112859953A (en) | 2021-01-08 | 2021-01-08 | Temperature control module in biological reaction instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110021316.9A CN112859953A (en) | 2021-01-08 | 2021-01-08 | Temperature control module in biological reaction instrument |
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| Publication Number | Publication Date |
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| CN112859953A true CN112859953A (en) | 2021-05-28 |
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| CN202110021316.9A Pending CN112859953A (en) | 2021-01-08 | 2021-01-08 | Temperature control module in biological reaction instrument |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115141746A (en) * | 2022-09-01 | 2022-10-04 | 鲲鹏基因（北京）科技有限责任公司 | Temperature control system of PCR instrument and PCR instrument |
| CN115505525A (en) * | 2022-11-10 | 2022-12-23 | 鲲鹏基因（北京）科技有限责任公司 | Temperature regulation and control compensation device of PCR instrument and PCR instrument |
| CN116179333A (en) * | 2023-04-19 | 2023-05-30 | 鲲鹏基因（北京）科技有限责任公司 | Temperature-controlled amplification device and PCR instrument |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03186746A (en) * | 1989-12-04 | 1991-08-14 | Miles Inc | Heater having phase change temperature controller |
| CN103752360A (en) * | 2013-12-30 | 2014-04-30 | 西安天隆科技有限公司 | Thermal module for biochemical reaction |
| CN109321212A (en) * | 2018-10-28 | 2019-02-12 | 西南电子技术研究所（中国电子科技集团公司第十研究所） | The preparation method of the compound PCM combined phasetransform temperature control component of nanotube |
| CN209169131U (en) * | 2019-01-14 | 2019-07-26 | 唐山达创传导科技有限公司 | Radiating fin mould group |
| CN209546219U (en) * | 2019-01-14 | 2019-10-25 | 唐山达创传导科技有限公司 | Radiator |
-
2021
- 2021-01-08 CN CN202110021316.9A patent/CN112859953A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03186746A (en) * | 1989-12-04 | 1991-08-14 | Miles Inc | Heater having phase change temperature controller |
| CN103752360A (en) * | 2013-12-30 | 2014-04-30 | 西安天隆科技有限公司 | Thermal module for biochemical reaction |
| CN109321212A (en) * | 2018-10-28 | 2019-02-12 | 西南电子技术研究所（中国电子科技集团公司第十研究所） | The preparation method of the compound PCM combined phasetransform temperature control component of nanotube |
| CN209169131U (en) * | 2019-01-14 | 2019-07-26 | 唐山达创传导科技有限公司 | Radiating fin mould group |
| CN209546219U (en) * | 2019-01-14 | 2019-10-25 | 唐山达创传导科技有限公司 | Radiator |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115141746A (en) * | 2022-09-01 | 2022-10-04 | 鲲鹏基因（北京）科技有限责任公司 | Temperature control system of PCR instrument and PCR instrument |
| CN115141746B (en) * | 2022-09-01 | 2022-11-08 | 鲲鹏基因（北京）科技有限责任公司 | Temperature control system of PCR instrument and PCR instrument |
| CN115505525A (en) * | 2022-11-10 | 2022-12-23 | 鲲鹏基因（北京）科技有限责任公司 | Temperature regulation and control compensation device of PCR instrument and PCR instrument |
| CN116179333A (en) * | 2023-04-19 | 2023-05-30 | 鲲鹏基因（北京）科技有限责任公司 | Temperature-controlled amplification device and PCR instrument |
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Country or region after: China Address after: Room 303-163, 3rd Floor, Building 4, No. 9 Yike Road, Life Science Park, Changping District, Beijing, 102206 (Cluster Registration) Applicant after: Kunpeng Gene (Beijing) Scientific Instrument Co.,Ltd. Applicant after: Kunpeng (Xuzhou) Scientific Instrument Co.,Ltd. Address before: 102200 429-1, 4th floor, building 1, yard 10, Longyu North Street, Huilongguan town, Changping District, Beijing Applicant before: ROCGENE TECNOLOGY Co. Country or region before: China Applicant before: Kunpeng (Xuzhou) Scientific Instrument Co.,Ltd. |