CN217809437U

CN217809437U - Nucleic acid constant temperature amplification detector

Info

Publication number: CN217809437U
Application number: CN202221403013.XU
Authority: CN
Inventors: 赖小强
Original assignee: Jiangsu Genuo Biotechnology Co ltd
Current assignee: Jiangsu Genuo Biotechnology Co ltd
Priority date: 2022-06-07
Filing date: 2022-06-07
Publication date: 2022-11-15
Anticipated expiration: 2032-06-07

Abstract

The utility model discloses a nucleic acid constant temperature amplification detector, including host computer casing and thermostatic mechanism, be provided with the hatch door on the up end of host computer casing, be provided with the liquid crystal touch-sensitive screen on the hatch door, thermostatic mechanism sets up the inside at the host computer casing, the liquid crystal touch-sensitive screen is connected with thermostatic mechanism electric property, be provided with optical detection subassembly and radiator unit on the host computer casing, thermostatic mechanism includes heating chip, heating seat, heating suit, a plurality of toper heating tank and locating hole, radiator unit's upper end is provided with the heating chip, the upper end of heating chip is provided with the heating seat; the utility model discloses simple structure, reasonable in design, reaction hole site and conventional PCR detection tube adaptation, its inboard be the back taper structure, make the detection tube fully with the reaction hole contact, heat conduction with higher speed improves reaction efficiency, makes the detection tube can the vertical fixation on the reaction hole site and the disappearance slope, and the accuse temperature homogeneity is good, and the energy consumption decreases the low.

Description

Nucleic acid constant temperature amplification detector

Technical Field

The utility model relates to a nucleic acid detector equipment technical field specifically is a nucleic acid constant temperature amplification detector.

Background

The PCR instrument (nucleic acid amplification detector) used at the present stage adopts a variable temperature control technology no matter metal bath or air bath, in the working process of the instrument, in order to realize rapid temperature rise and fall, high-power and high-energy-consumption devices are often needed, and the heating or refrigeration of the temperature is rapidly realized to meet the temperature requirement of the experiment process of the PCR instrument, so that the power consumption of most of the PCR instruments at present is very high.

The defects of the prior art are as follows:

the existing nucleic acid amplification detector generally comprises a temperature control module, a hot cover component, a fluorescence detection module, a control circuit board, a main control computer and a power supply, and in order to meet the requirement of multi-sample batch detection, the size of the detector is large, reaction holes of a PCR instrument which is mainstream in the market are generally cylindrical, the adhesion degree of the reaction holes and a conventional PCR detection tube is poor, the heat transfer rate between the reaction holes and the PCR detection tube is slow, and the reaction efficiency is reduced.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a nucleic acid constant temperature amplification detector to solve the problem that proposes in the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme: a nucleic acid constant-temperature amplification detector comprises a host shell and a constant-temperature mechanism, wherein a cabin door is arranged on the upper end surface of the host shell, a liquid crystal touch screen is arranged on the cabin door, the constant-temperature mechanism is arranged inside the host shell, the liquid crystal touch screen is electrically connected with the constant-temperature mechanism, and an optical detection assembly and a heat dissipation assembly are arranged on the host shell;

constant temperature mechanism is including heating chip, heating seat, heating suit, a plurality of toper heating tank and locating hole, radiator unit's upper end is provided with heating chip, heating chip's upper end is provided with the heating seat, the upper end of heating seat is provided with the heating suit, be provided with a plurality of toper heating tank on the heating suit, the lower extreme of toper heating tank is provided with the locating hole.

Preferably, the optical detection subassembly is including a plurality of transmitting light source hole, a plurality of acceptance light source hole, a plurality of heat insulating board, transmitting light source PCB board and receipt light PCB board, the both sides of heating suit lower extreme are provided with a plurality of transmitting light source hole and a plurality of acceptance light source hole respectively, it has the heat insulating board to divide equally cloth in the both sides of heating chip, the heat insulating board is provided with transmitting light source PCB board and receives the light PCB board on keeping away from the side each other of one side, transmitting light source PCB board and receipt light PCB board and liquid crystal touch screen electric connection.

Preferably, the heat dissipation assembly comprises an air inlet, an air outlet, a fan and a heat dissipation block, the air inlet and the air outlet are respectively arranged on two sides of the host shell, the fan is arranged on one side, close to the air outlet, of the inside of the host shell, the heat dissipation block is arranged on the lower end face of the inside of the host shell, and the heating chip and the heat insulation plate are both arranged on the upper end face of the heat dissipation block.

Preferably, one side of the main housing is provided with a power socket and a connection socket.

Preferably, grid plates are arranged inside the air inlet and the air outlet on the main machine shell.

Preferably, be provided with the PCR detection nest of tubes on the heating cover group, the PCR detection nest of tubes is including PCR support, PCR pipe, sealed pad and sealed lid, be provided with a plurality of PCR pipe on the PCR support, PCR pipe and toper heating groove looks adaptation, be provided with sealed pad on the PCR support, be provided with sealed lid in the upper end that seals up on the PCR support.

Preferably, the heat insulating board sets up on the radiating block, heat insulating board, emission light source PCB board and receipt light PCB board all are provided with emission light source hole and receive light source hole assorted through-hole.

Compared with the prior art, the beneficial effects of the utility model are that:

this nucleic acid constant temperature amplification detector, through being provided with constant temperature mechanism, constant temperature mechanism is including heating chip, heating seat, heating suit, a plurality of toper heating bath and locating hole, reaction hole site and conventional PCR detecting tube adaptation, and its inboard is the back taper structure, makes the detecting tube fully with the reaction hole contact, heat conduction with higher speed improves reaction efficiency, makes the detecting tube can the vertical fixation on the reaction hole site and the slope does not appear, and the accuse temperature homogeneity is good, and the energy consumption decreases lowly.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a perspective view of the thermostatic mechanism of the present invention;

FIG. 3 is an exploded view of the thermostatic mechanism of the present invention;

FIG. 4 is an overall perspective view of the present invention;

fig. 5 is an overall side view of the present invention;

FIG. 6 is an exploded view of the PCR detector tube assembly of the present invention.

In the figure: 1. a main housing; 101. a cabin door; 102. a power outlet; 103. a connecting socket; 104. a grid plate; 2. a constant temperature mechanism; 21. heating the chip; 22. a heating base; 23. heating the sleeve set; 24. a conical heating tank; 25. positioning holes; 3. a liquid crystal touch screen; 4. a light emitting source aperture; 5. a light receiving aperture; 6. A heat insulation plate; 7. an emission light source PCB board; 8. receiving the light PCB; 9. an air inlet; 10. an air outlet; 11. a fan; 12. a heat dissipating block; 13. PCR support; 14. a PCR tube; 15. a gasket; 16. and (7) sealing the cover.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like are used in the orientation or positional relationship indicated on the basis of the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, are not to be construed as limiting the invention.

In the description of this patent, it is noted that unless otherwise specifically stated or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly and can include, for example, fixed connections, arrangements, detachable connections, arrangements, or integral connections and arrangements. The specific meaning of the above terms in this patent may be understood by one of ordinary skill in the art as appropriate.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.

Referring to fig. 1-6, the technical solution of the nucleic acid isothermal amplification detector provided by the present invention is: the utility model provides a nucleic acid constant temperature amplification detector, including host computer casing 1 and thermostatic mechanism 2, install hatch 101 through the hinge on the up end of host computer casing 1, install liquid crystal touch-sensitive screen 3 on the hatch 101, thermostatic mechanism 2 installs the inside at host computer casing 1, liquid crystal touch-sensitive screen 3 and thermostatic mechanism 2 electric connection, install optical detection subassembly and radiator unit on the host computer casing 1, thermostatic mechanism 2 is including heating chip 21, heating seat 22, heating suit 23, a plurality of toper heating groove 24 and locating hole 25, heating chip 21 is installed to radiator unit's upper end, heating seat 22 is installed to heating chip 21's upper end, heating suit 23 is installed to heating seat 22's upper end, be formed with a plurality of toper heating groove 24 on the heating suit 23, the lower extreme of toper heating groove 24 is formed with locating hole 25, put PCR pipe 14 into equipment toper heating groove 24, close the hatch, operate at liquid crystal touch-sensitive screen 3, send the detection instruction, heating chip 21 work heating temperature rises to regulation temperature and keeps this temperature, carry out the constant temperature amplification in the sample thermostatic mechanism 2 in PCR pipe 14.

The optical detection component comprises a plurality of light emitting source holes 4, a plurality of light receiving source holes 5, a plurality of heat insulation plates 6, a light emitting source PCB 7 and a light receiving PCB 8, a plurality of light emitting source holes 4 and a plurality of light receiving source holes 5 are formed on two sides of the lower end of the heating sleeve group 23 respectively, the heat insulation plates 6 are distributed on two sides of the heating chip 21, the light emitting source PCB 7 and the light receiving PCB 8 are mounted on the side surfaces of the heat insulation plates 6 far away from one side, the light emitting source PCB 7 and the light receiving PCB 8 are electrically connected with the liquid crystal touch screen 3, constant temperature amplification is carried out in the sample constant temperature mechanism 2 in the PCR tube 14, the optical detection component detects a reaction sample, and the liquid crystal touch screen 3 displays detection data and analysis results; the printing instruction can be input through the liquid crystal touch screen 3, the analysis result is printed by the micro printer, the analysis result can also be exported through the data transmission module, and the instrument can be interconnected with the HIS (or LIS) information of the hospital system through the data transmission interface.

Radiator unit is including air intake 9, air outlet 10, fan 11 and radiating block 12, air intake 9 and air outlet 10 have been seted up respectively to the both sides of host casing 1, the inside one side that is close to air outlet 10 of host casing 1 installs fan 11, install radiating block 12 on the inside lower terminal surface of host casing 1, heating chip 21 and heat insulating board 6 are all installed on the up end of radiating block 12, after accomplishing the detection, can start fan 11, drive the inside quick circulation of air of host casing 1 through fan 11 and cool down.

A power socket 102 and a connection socket 103 are installed on one side of the host casing 1, so that power can be supplied to the power supply of the host casing 1, and data results can be derived conveniently.

Grid plates 104 are arranged inside the air inlet 9 and the air outlet 10 on the main machine shell 1, so that foreign matters can be prevented from entering the main machine shell 1 in the cooling process.

The heating sleeve set 23 is provided with a PCR detection tube assembly which comprises a PCR support 13, PCR tubes 14, a sealing gasket 15 and a sealing cover 16, the PCR support 13 is provided with a plurality of PCR tubes 14, the PCR tubes 14 are matched with the conical heating groove 24, the PCR support 13 is provided with the sealing gasket 15, and the PCR support 13 is provided with the sealing cover 16 at the upper end of the sealing gasket 15.

The heat insulation plate 6 is arranged on the heat dissipation block 12, and the heat insulation plate 6, the light emitting source PCB 7 and the light receiving PCB 8 are all provided with through holes which are matched with the light emitting source holes 4 and the light receiving source holes 5.

The utility model discloses a theory of operation as follows:

when the nucleic acid constant-temperature amplification detector is used, a user starts the detector, opens the cabin door 101 upwards, puts the PCR tube 14 into the equipment conical heating groove 24, closes the cabin door 101, operates on the liquid crystal touch screen 3, sends a detection instruction, raises the working heating temperature of the heating chip 21 to a specified temperature and keeps the temperature, performs constant-temperature amplification in the sample constant-temperature mechanism 2 in the PCR tube 14, detects a reaction sample by the optical detection assembly, and displays detection data and an analysis result on the liquid crystal touch screen 3; can print the instruction through 3 inputs of liquid crystal touch-sensitive screen, the analysis result is printed by micro printer, also can derive the analysis result through data transmission module, instrument accessible data transmission interface and hospital system HIS (or LIS) information interconnection, this device reaction hole site and conventional PCR test tube adaptation, its inboard is the back taper structure, make the test tube fully contact with the reaction hole, heat conduction with higher speed, improve reaction efficiency, make the test tube can the vertical fixation on the reaction hole site and the slope does not appear, accuse temperature homogeneity is good, the energy consumption decreases lowly.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It should be understood by those skilled in the art that the present invention is not limited by the above embodiments, and the description in the above embodiments and the description is only preferred examples of the present invention, and is not intended to limit the present invention, and that the present invention can have various changes and modifications without departing from the spirit and scope of the present invention, and these changes and modifications all fall into the scope of the claimed invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. The utility model provides a nucleic acid constant temperature amplification detector, includes host computer casing (1) and constant temperature mechanism (2), its characterized in that: a cabin door (101) is arranged on the upper end surface of the main machine shell (1), a liquid crystal touch screen (3) is arranged on the cabin door (101), the constant temperature mechanism (2) is arranged inside the main machine shell (1), the liquid crystal touch screen (3) is electrically connected with the constant temperature mechanism (2), and an optical detection assembly and a heat dissipation assembly are arranged on the main machine shell (1);

constant temperature mechanism (2) is including heating chip (21), heating seat (22), heating suit (23), a plurality of toper heating groove (24) and locating hole (25), radiator unit's upper end is provided with heating chip (21), the upper end of heating chip (21) is provided with heating seat (22), the upper end of heating seat (22) is provided with heating suit (23), be provided with a plurality of toper heating groove (24) on heating suit (23), the lower extreme of toper heating groove (24) is provided with locating hole (25).

2. The isothermal nucleic acid amplification detector of claim 1, wherein: the optical detection subassembly is including a plurality of transmitting light source hole (4), a plurality of receiving light source hole (5), a plurality of heat insulating board (6), transmitting light source PCB board (7) and receiving light PCB board (8), the both sides of heating suit (23) lower extreme are provided with a plurality of transmitting light source hole (4) and a plurality of respectively and accept light source hole (5), it has heat insulating board (6) to distribute equally in the both sides of heating chip (21), heat insulating board (6) are kept away from each other and are provided with transmitting light source PCB board (7) and receive light PCB board (8) on the side of one side, transmitting light source PCB board (7) and receiving light PCB board (8) and liquid crystal touch screen (3) electric connection.

3. The nucleic acid isothermal amplification detector of claim 1, wherein: radiator unit is including air intake (9), air outlet (10), fan (11) and radiating block (12), the both sides of host casing (1) are provided with air intake (9) and air outlet (10) respectively, the inside one side that is close to air outlet (10) of host casing (1) is provided with fan (11), be provided with radiating block (12) on the inside lower terminal surface of host casing (1), heating chip (21) and heat insulating board (6) all set up on the up end of radiating block (12).

4. The nucleic acid isothermal amplification detector of claim 1, wherein: one side of the main machine shell (1) is provided with a power socket (102) and a connecting socket (103).

5. The isothermal nucleic acid amplification detector of claim 3, wherein: grid plates (104) are arranged inside the air inlet (9) and the air outlet (10) on the main machine shell (1).

6. The nucleic acid isothermal amplification detector of claim 1, wherein: heating cover group (23) is last to be provided with the PCR detection tube subassembly, the PCR detection tube group is including PCR support (13), PCR pipe (14), sealed pad (15) and sealed lid (16), be provided with a plurality of PCR pipe (14) on PCR support (13), PCR pipe (14) and toper heating tank (24) looks adaptation, be provided with sealed pad (15) on PCR support (13), be provided with sealed lid (16) in the upper end that seals pad (15) on PCR support (13).

7. The nucleic acid isothermal amplification detector of claim 2, wherein: the heat insulation plate (6) is arranged on the heat dissipation block (12), and the heat insulation plate (6), the light emitting source PCB (7) and the light receiving PCB (8) are provided with through holes which are matched with the light emitting source holes (4) and the light receiving source holes (5).