CN1150910A

CN1150910A - Osteophytosis pill and its compounding method

Info

Publication number: CN1150910A
Application number: CN96118666A
Authority: CN
Inventors: 花茂时
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-04-18
Filing date: 1996-04-18
Publication date: 1997-06-04
Anticipated expiration: 2016-04-18
Also published as: CN1058156C

Abstract

A Chinese-medicinal pill for treating hyperosteogeny with high curative effect and without any toxic and side-effect is prepared from 42 Chinese-medicinal materials such as Chinese angelica root, prepared rehmannia root, yam, parched white atractylodes rhizome, etc. The yam and parched white atractylodes rhizome, are crushed into fine powder, sieved and ready for use. The dregs and other 39 ingredients (except musk) are decoted twice, then combine decoctions, filter, concentrate into thick paste and mix with said powder. It is then dried, breaked, sieved. Add in musk and honey, and form into pills.

Description

Chinese pill for curing hyperosteogeny and compound method thereof

The present invention relates to a kind of Chinese medicine and compound method thereof, particularly a kind of pill and compound method thereof of eliminating and suppressing hyperosteogeny.

At present, both at home and abroad medical circle is for the also satisfied without comparison medicine of the treatment of hyperosteogeny, because primary disease is a kind ofly to suffer sclerotin degenerative disease due to the chronic injury by bone or articular cartilage degeneration and joint.Clinical bone joint pain, swelling, discomfort, the limitation of activity of mainly showing as.The traditional Chinese medical science thinks that primary disease belongs to the category of " migratory arthralgia " " arthralgia due to cold " " arthralgia chiefly caused by damp pathogen ".Modern medicine is thought: with advancing age, degeneration little by little takes place in human intervertebral disc, fibre board elastic force goes down, intervertebral disc is outstanding to all around, the intervertebral space stenosis is narrow, vertebral rim hypertrophy, intervertebral instability, the Secondary cases in hypertrophy of ligamentum flavum, degeneration, unciform process joint hyperplasia and little joint change and form.The traditional Chinese medical science is thought the generation of primary disease, how because of the kidney qi decline, overworks, and " wind, cold, wet " is rich mutually, sends out and is due to the numbness, and it is dirty to relate generally to kidney,spleen,liver three.

Treatment to primary disease, the Western medicine choice drug is " sodium salicylate " each 1.5-2g at present, three (list of references " the clinical handbook of practical combination of Chinese and Western medicine Xueyuan Press publication every day, in August, 1989), but this medicine can not effect a radical cure primary disease, and have very strong toxic and side effects, as occur feeling sick, digestive tract irritation such as vomiting, can cause gastrorrhagia.The clothes heavy dose also can make thrombinogen reduce and cause the systemic bleeding tendency for a long time, headache, dizzy, tinnitus, audiovisual power go down, abalienation, collapse, stupor, acidemia etc. can appear in severe patient, and anaphylaxiss such as erythra, nervus vasculairs edema, asthma can occur.Dosage is big more, the course of treatment is long more, and how obvious above-mentioned side effect is.Chinese medicine is " Decoction of Notopterygium for Rheumatism " (list of references " pharmacology of Chinese medical formulae " to the treatment of primary disease side commonly used, high medical college teaching material, Shanghai science tech publishing house publishes, in April, 1993), add to simplify with this side and cut out the treatment primary disease and still can not reach satisfactory effect, this side just in the Wei Liangxu of battalion, wind, cold, wet sanction utilization when being detained meridians, has the effect of supplementing QI to normalize nutrient QI, expelling wind and dampness, often so and delay treatment.

The objective of the invention is to overcome the shortcoming of above-mentioned prior art, proposed a kind of pill that effects a radical cure hyperosteogeny--hypertrophy ball and compound method thereof, be characterized in that this medicine is pure Chinese medicinal preparation, without any side effects, strengthening vital QI to eliminate pathogenic factors, treating both the principal and the secondary aspects of a disease at the same time has blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, kidney tonifying is strengthened muscle, suppress and eliminate the effect of hyperosteogeny, make and set upright and help eliminating evilly, heresy is gone and is not hindered, among the kidney tonifying spleen invigorating with soothing liver-QI, make eutopic reduction and do not have the worry of the stagnation of QI, in eliminating evil, hold concurrently, heresy is gone and do not have a fraud of the stasis of blood of staying with blood circulation promoting and blood stasis dispelling, to the bone matrix hyperplasia treating both the principal and the secondary aspects of a disease at the same time, have good effect, late result is particularly remarkable, can fully recover and more back nothing recurrence.

Prescription of the present invention is a monarch drug with Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Paeoniae Alba, Fructus Corni, Fructus Lycii, is ministerial drug with Sanguis Draxonis, Semen Persicae, Flos Carthami, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, Rhizoma Gastrodiae, Squama Manis, Herba Pyrolae, Moschus, Radix Angelicae Pubescentis, Radix Clematidis, Caulis Spatholobi, Herba Taxilli, Bombyx Batryticatus, Fructus Chaenomelis, Pheretima; With Carapax et Plastrum Testudinis, Carapax Trionycis, Radix Dipsaci, the Cortex Eucommiae, the Radix Astragali, to process the five tastes, Rhizoma Cibotii, Rhizoma Curculiginis, Ba Zhantian, Herba Cistanches, Rhizoma Drynariae, Herba Epimedii, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae (parched) be adjuvant drug; With Radix Puerariae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae, Fructus Jujubae, the various medicine content of Radix Glycyrrhizae Preparata is messenger drug. are respectively: the stiff silkworm 1-3% of Radix Angelicae Sinensis 1-3% cultivated land 2-5% Ligusticum wallichii 1-3% Hangzhoupro Chinese herbaceous peony 1-3% cornus officinalis sieb et zucc 1-3% fruit of Chinese wolfberry 1-3% dragon's blood 0.3-2% peach kernel 1-3% safflower 1-3% red sage root 3-5% frankincense 1-3% myrrh 1-3% rhizoma Gastrodiae 1-3% pangolin 1-3% pyrola 1-3% Moschus 0.01-0.2% levisticum 1-3% root of Chinese clematis 3-5% reticulate millettia 3-5% parasitic loranthus 2-4% pawpaw 3-5% earthworm 1-3% tortoiseshell 1-3% turtle shell 1-3% teasel root 1-3% bark of eucommia 1-3% Radix Astragali 3-5% processs five tastes 1-3% rhizoma cibotii 1-3% thizoma curculiginis 1-3% bar war day 1-3% saline cistanche 1-3% rhizome of davallia 1-3% barrenwort 1-3% Chinese yam 14-20% rhizoma atractylodis macrocephalae 10-15% root of kudzu vine 1-3% root of Dahurain angelica 0.5-2% root of bidentate achyranthes 1-3% date 1-3% honey-fried licorice root 0.5-2% most preferred embodiment percentage: Radix Angelicae Sinensis 1.76; Radix Rehmanniae Preparata 3.51; The Radix Paeoniae Alba 1.76; Rhizoma Chuanxiong 1.41; Semen Persicae 1.17; Flos Carthami 1.17; Squama Manis 1.05; Sanguis Draxonis 0.70; Pheretima 1.17; Bombyx Batryticatus 1.17; Olibanum 1.17; Myrrha 1.17; Caulis Spatholobi 3.51; Rhizoma Gastrodiae 1.17; Fructus Chaenomelis 3.51; Radix Salviae Miltiorrhizae 3.51; Herba Taxilli 3.51; Radix Angelicae Pubescentis 1.76; Radix Clematidis 3.51; The Radix Astragali 3.51; Process the five tastes 1.76; Fructus Corni 1.76; Fructus Lycii 1.76; Radix Dipsaci 1.76; Rhizoma Cibotii 1.76; The Cortex Eucommiae 1.76; Rhizoma Curculiginis 1.76; Crust war sky 2.34; Carapax et Plastrum Testudinis 1.17; Carapax Trionycis 1.17; Moschus 0.06; Herba Cistanches 1.76; Herba Pyrolae 1.76; Rhizoma Drynariae 2.34; Herba Epimedii 2.34; Rhizoma Dioscoreae 14.06; Rhizoma Atractylodis Macrocephalae (parched) 14.06; Radix Puerariae 1.05; The Radix Angelicae Dahuricae 0.70; Radix Achyranthis Bidentatae 1.76; Fructus Jujubae 1.17; Radix Glycyrrhizae Preparata 0.70.

Technology of the present invention is as follows:

With above 42 flavor medicines, take out in proportion.The Rhizoma Dioscoreae Rhizoma Atractylodis Macrocephalae (parched with bran) is ground into fine powder, sieving for standby, recrement and other the 30 ball flavor medicine except that Moschus decoct with water twice, each about 2～4 hours, after collecting decoction, the filtration, when filtrate is condensed into thick paste＜80 ℃ relative density be approximately 1.27～1.30＞with above-mentioned medicated powder mix homogeneously, dry, pulverize, sieve, add Moschus, refining Mel, make big close ball with warm driving fit medicine raft, promptly.

The present invention aims at bone matrix hyperplasia and establishes.With advancing age, the spleen insufficiency of blood, kidney qi fails gradually, when the kidney tonifying of enriching blood, so put down with Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Paeoniae Alba, Fructus Corni, the sweet of Fructus Lycii, to enrich blood, to transfer blood, kidney tonifying, make " the kidney being the origin of congenital constitution " main to some extent, " the spleen being the foundation of acquired constitution ", spleen blood biochemistry is infinite, is monarch drug so choose Six-element.Wind, cold, wet, heresy is rich mutually, when eliminating evil, so with Pheretima, Fructus Chaenomelis, Herba Taxilli, Rhizoma Gastrodiae, Radix Angelicae Pubescentis, Radix Clematidis, Moschus expelling wind and dampness, dispersing cold for relieving pain, dredge the meridian passage.Disease then becomes the stasis of blood for a long time, and blood fortune is not smooth, the passages through which vital energy circulates stagnation of QI and blood may bring about pain, it is unfavorable that the joint song is stretched, and then need be equipped with blood circulation promoting and blood stasis dispelling among eliminating evil, so with Sanguis Draxonis, Semen Persicae, Flos Carthami, Herba Pyrolae, Caulis Spatholobi, Bombyx Batryticatus, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, Squama Manis promoting blood circulation, removing blood stasis and relieving pain go heresy and do not stay the stasis of blood, so be ministerial drug.Though evil going, though pain end and can not eradicate, so with Carapax et Plastrum Testudinis, Carapax Trionycis, Radix Dipsaci, Du stretch, Rhizoma Cibotii, Rhizoma Curculiginis, Ba Zhantian, Herba Cistanches, Rhizoma Drynariae, Herba Epimedii, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae (parched) assist monarch drug, spleen invigorating helps fortune, the hemopoietic of enriching blood, kidney tonifying are strengthened muscle, so be adjuvant drug.Radix Puerariae, that the Radix Angelicae Dahuricae draws blood is up, the Radix Achyranthis Bidentatae conducting blood to flow downwards, and Fructus Jujubae, Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription are strengthened the through sick institute of all medicines.Full side 42 flavor medicines share, and become blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, hard masses softening and resolving, easing the affected liver, spleen invigorating, kidney tonifying altogether.Make and set upright and favourable eliminating evil, heresy is gone and is not just hindered, and with soothing liver-QI, makes eutopic reduction and does not have a worry of the stagnation of QI among the kidney tonifying spleen invigorating, holds concurrently among eliminating evil and reduces phlegm with dissipating blood stasis, heresy is gone and does not have the fraud of the stasis of blood of staying, and reaches the effect that suppresses and eliminate for hyperosteogeny.

The present invention has carried out 384 example experiments altogether, and all cases are all checked through film making of X line or MRI, are diagnosed as hyperosteogeny in conjunction with clinical symptoms.Hyperosteogeny of cervical vertebra 288 examples wherein, lumbar vertebra hyperosteogeny 40 examples, knee joint hyperosteogeny 16 examples, hyperosteogeny 4 examples, merge hyperosteogeny 36 examples, male 194 examples, women 190 examples, oldest 80 years old, 28 years old of age minimum, the more than two decades that the course of disease is the longest, the shortest two months.

Criterion of therapeutical effect: (one) clinical cure: treat transference cures such as the back is lopsided corrects, sour, numb, as to swell and ache, functional rehabilitation is normal, does not have more than 2 years and recurs; (2) produce effects: treatment back deformity is basic corrects, and symptoms such as acid, fiber crops, swollen, pain disappear substantially, and function is recovered substantially; (3) effective: treatment back deformity is corrected to some extent, and symptoms such as acid, fiber crops, swollen, pain have the part disappearance, and function is recovered to some extent; (4) invalid: all are with before treating.A) hyperosteogeny of cervical vertebra totally 288 examples: clinical cure 278 examples, produce effects 10 examples, effective 0 example, invalid 0 example.B) lumbar vertebra hyperosteogeny totally 40 examples: clinical cure 32 examples, produce effects 4 examples, effective 2 examples, invalid 2 examples.C) knee joint hyperosteogeny totally 16 examples: clinical cure 12 examples, produce effects 2 examples, effective 1 example, invalid 1 example.D) hyperosteogeny totally 4 examples: clinical cure 2 examples, produce effects 1 example, effective 0 example, invalid 1 example.E) merge hyperosteogeny 36 examples: clinical cure 30 examples, produce effects 4 examples, effective 2 examples, invalid 0 example.

Therapeutic outcome; Clinical recovery 354 examples, produce effects 21 examples, effective 5 examples, invalid 4 examples, total effective rate is 98%, cure rate is 92%.

Typical case's medical record is given an example:

The field, the man, 52 years old, 90 years conscious cervical regions, back, shoulder pain, pain to arm and finger radiation and with headache, dizzy, feel sick, symptoms such as vomiting, tinnitus, numbness of hand.The big First Academy checks in doctor trained in Western medicine, and X line film making prompting: (1) neck 4.5 right side unciform process hypertrophy hypertrophys, corresponding intervertebral foramina diminish; (2) ligamentum nuchae ossification.MRI checks suggestion: (1) neck 3,4,5 hyperosteogenys; (2) neck 5-6 intervertebral disk hernia.Be diagnosed as cervical spondylosis (spiritual root type merges the arteries and veins type that promotes).This patient's state of an illness is heavier, once is in hospital several times, oral in, treatment such as Western medicine, physical therapy, massage, medicine external application, Hyperbaric oxygen chamber all do not have obvious curative effects.Adopted the hypertrophy pill for curing in 92 years, and received produce effects after 2 courses of treatment, above-mentioned symptom disappears substantially, and recovery from illness can be driven motorcycle and be gone at express speed after 70 days.Adhere to taking medicine 5 courses of treatment, do not have recurrence in 4 years subsequently so far.

Chen, the woman, 80 years old, found the cervical pain discomfort in 91 years, dizziness, myasthenia of limbs has " stepping on the Cotton Gossypii sensation " during walking, and the centre of body weight shakiness is easily fallen down, and can not keep straight on.Point out at the doctor trained in Western medicine X of big First Academy ray examination: neck 3,4,5 hypertrophy are diagnosed as cervical spondylosis (myeloid form).Take the hypertrophy ball, above-mentioned symptom disappears substantially after two courses of treatment, takes recovery from illness 5 courses of treatment continuously, does not have recurrence so far.

Section certain, the man 48 years old, suffers from hyperosteogeny for many years, X sheet inspection prompting, the serious hypertrophy of lumbar vertebra, L ₃-L ₄Between this formation of bone abutment, waist is ached, numbness of lower limbs is unable, through curing no produce effects in many ways.Took the hypertrophy ball in 94 years, receive produce effects after the course of treatment, above-mentioned symptom disappears substantially, adheres to 5 courses of treatment of medication, and recovery from illness does not have recurrence so far.

The Wang, the man, 80 years old, double knee joint swelled and ache unbearable, and friction sound, stiff, limitation of activity, difficulty in walking are arranged, and only can hold up dolly to move one's steps surplus in the of ten year on ordinary days.The inspection of X sheet is as seen: hyperosteogeny forms, and the joint space narrows down, has episome, synovial membrane edema, is diagnosed as the hypertrophy gonarthritis.Very good with effect behind the hypertrophy pill for curing, take medicine and just felt pain relief in back second day, but sustaining wall walking in the 3rd day.Above-mentioned symptom disappears substantially after two courses of treatment, adheres to 5 courses of treatment of medication, and recovery from illness is recurrence so far.

Claims

1, hypertrophy ball, feature of the present invention is: Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Paeoniae Alba, Fructus Corni, Fructus Lycii are monarch drug, are ministerial drug with Sanguis Draxonis, Semen Persicae, Flos Carthami, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, Rhizoma Gastrodiae, Squama Manis, Herba Pyrolae, Moschus, Radix Angelicae Pubescentis, Radix Clematidis, Caulis Spatholobi, Herba Taxilli, Bombyx Batryticatus, Fructus Chaenomelis, Pheretima; With Carapax et Plastrum Testudinis, Carapax Trionycis, Radix Dipsaci, the Cortex Eucommiae, the Radix Astragali, to process the five tastes, Rhizoma Cibotii, Rhizoma Curculiginis, Ba Zhantian, Herba Cistanches, Rhizoma Drynariae, Herba Epimedii, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae (parched) be adjuvant drug; With Radix Puerariae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae, Fructus Jujubae, Radix Glycyrrhizae Preparata is messenger drug.

2, hyperplasia ball according to claim 1; It is characterized in that the composition of said medicine is: the stiff silkworm 1-3% of Radix Angelicae Sinensis 1-3% cultivated land 2-5% Ligusticum wallichii 1-3% Hangzhoupro Chinese herbaceous peony 1-3% sweet potato meat 1-3% fruit of Chinese wolfberry 1-3% dragon's blood 0.3-2% peach kernel 1-3% safflower 1-3% red sage root 3-5% frankincense 1-3% myrrh 1-3% rhizoma Gastrodiae 1-3% pangolin 1-3% pyrola 1-3% Moschus 0.01-0.2% levisticum 1-3% root of Chinese clematis 3-5% reticulate millettia 3-5% parasitic loranthus 2-4% pawpaw 3-5% earthworm 1-3% tortoiseshell 1-3% turtle shell 1-3% teasel root 1-3% bark of eucommia 1-3% Radix Astragali 3-5% processs five tastes 1-3% rhizoma cibotii 1-3% thizoma curculiginis 1-3% bar war day 1-3% saline cistanche 1-3% rhizome of davallia 1-3% barrenwort 1-3% Chinese yam 14-2 0% a rhizoma atractylodis macrocephalae 10-15% root of kudzu vine 1-3% root of Dahurain angelica 0.5-2% root of bidentate achyranthes 1-3% date 1-3% and processs Radix Glycyrrhizae 0.5-2%.

3, according to claim 1,2 described hypertrophy balls, it is characterized in that the percentage ratio of said pharmaceutical compositions is: Radix Angelicae Sinensis 1.76, Radix Rehmanniae Preparata 3.51, the Radix Paeoniae Alba 1.76, Rhizoma Chuanxiong 1.41, Semen Persicae 1.17, Flos Carthami 1.17, Squama Manis 1.05, Sanguis Draxonis 0.70, Pheretima 1.17, Bombyx Batryticatus 1.17, Olibanum 1.17, Myrrha 1.17, Caulis Spatholobi 3.51, Rhizoma Gastrodiae 1.17, Fructus Chaenomelis 3.51, Radix Salviae Miltiorrhizae 3.51, Herba Taxilli 3. 51, Radix Angelicae Pubescentis 1.76, Radix Clematidis 3.51, the Radix Astragali 3.51, process the five tastes 1.76, Fructus Corni 1.76, Fructus Lycii 1.76, Radix Dipsaci 1.76, Rhizoma Cibotii 1.76, the Cortex Eucommiae 1.76, Rhizoma Curculiginis 1.76, crust war sky 2.34, Carapax et Plastrum Testudinis 1.17, Carapax Trionycis 1.17, Moschus 0.06, Herba Cistanches 1.76, Herba Pyrolae 1.76, Rhizoma Drynariae 2.34, Herba Epimedii 2.34, Rhizoma Dioscoreae 14.06, Rhizoma Atractylodis Macrocephalae (parched) 14.06, Radix Puerariae 1.05, the Radix Angelicae Dahuricae 0.70, Radix Achyranthis Bidentatae 1.76, Fructus Jujubae 1.17, Radix Glycyrrhizae Preparata 0.70.

4, according to the compound method of claim 1,2 described hypertrophy balls, at first with above 42 flavor medicines, take out in proportion, it is characterized in that, the Rhizoma Dioscoreae Rhizoma Atractylodis Macrocephalae (parched with bran) is ground into fine powder, sieving for standby, recrement and other the 39 flavor medicine except that Moschus decoct with water twice, each about 2～4 hours, after collecting decoction, the filtration, when filtrate is condensed into thick paste＜80 ℃ relative density be approximately 1.27～1.30＞with above-mentioned medicated powder mix homogeneously, dry, pulverize, sieve, add Moschus, refining Mel, make big close ball with warm driving fit medicine raft, promptly.