CN101744895A - Medical preparation for treatment of rheumatism, lumbar vertebra disease and cervical spondylosis - Google Patents
Medical preparation for treatment of rheumatism, lumbar vertebra disease and cervical spondylosis Download PDFInfo
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Abstract
The invention discloses a medical preparation for treatment of rheumatism, lumbar vertebra diseases and cervical spondylosis, which is a purely traditional Chinese preparation prepared through extraction and processing of white paeony root, hoantchy root, angelica, eucommia bark, chaff flower root, pawpaw, rhizome of large-headed atractylodes, giant knotweed, liquorice and the like in alcohol or water. The medical preparation can be a wine preparation, a capsule preparation, a pill preparation, a tablet preparation and a mistura preparation. Moreover, the medical preparation has the functions of supplementing qi, activating the blood circulation, strengthening the muscles and bones, dispersing the pathogenic wind, and treating arthralgiasyndrome, and can be applied in treatment of rheumatism, lumbar vertebra diseases and cervical spondylosis.
Description
Technical field
The present invention relates to a kind of medicament that is used for the treatment of rheumatism, waist cervical spondylosis.
Background technology
Medical circle is often said " rheumatism is non-pathogenic cancer, is the chronic killer of osteopathia, is the early signal of paralysis ".From ancient times to the present, rheumatism, osteopathia are listed in one of world's refractory disease always.The scope of rheumatism, osteopathia is more extensive, except that rheumatic arthritis, and the rheumatoid arthritis of modern medicine, arthralgia, ankylosing spondylitis, gouty arthritis, osteoarthritis, waist cervical spondylosis (intervertebral disk hernia, hyperosteogeny), sciatica etc. all belong to the scope of rheumatic osteopathia.This is wherein especially with rheumatic arthritis, and waist cervical spondylosis prevalence is the highest, and disturbed number is also numerous.
And the medicament of existing treatment rheumatism, waist cervical spondylosis has the hot removing damp and stopping pain capsule of FENGLIAOXING FENGSHI DIEDA YAOJIU, WANTONG JINGU PIAN, the heart of a lotus seed etc., mostly contains the toxicity medical material as Radix Aconiti Lateralis Preparata, Radix Aconiti, Radix Aconiti Kusnezoffii, Semen Strychni etc.The medicine of rare special for treating waist cervical spondylosis on the market.
Summary of the invention
Purpose of the present invention aims to provide a kind of pure Chinese medicinal preparation that is used for the treatment of rheumatism, waist cervical spondylosis.
The objective of the invention is to realize by following manner:
A kind of medicament that is used for the treatment of rheumatism, waist cervical spondylosis is mainly made by water or alcohol extraction by following bulk drugs: Radix Paeoniae Alba 5-30 part, Rhizoma Polygoni Cuspidati 5-30 part, Radix Angelicae Sinensis 5-30 part.
Described medicament can be medicated wine, capsule, pill, tablet or mixture.
Described medicated wine is that crude drug was made with soaking in Chinese liquor in 15～30 days.
Described medicament can also add: Radix Astragali 5-30 part, Cortex Eucommiae 5-30 part, Radix Achyranthis Bidentatae 5-30 part, Fructus Chaenomelis 5-30 part, Radix Glycyrrhizae 5-30 part.
Described medicament can also add: Radix Astragali 5-30 part, Cortex Eucommiae 5-30 part, Flos Carthami 5-30 part, Radix Clematidis 5-30 part, Radix Glycyrrhizae 5-30 part, Rhizoma Atractylodis Macrocephalae 5-30 part, Radix Achyranthis Bidentatae 5-30 part, Fructus Chaenomelis 5-30 part.
Medicament of the present invention can be medicated wine, capsule, pill, tablet, mixture.Preparation process can be passed through water or alcohol extraction, makes the Chinese medicine finished product preparation again.
The present invention is the pure Chinese medicinal preparation of being made by adding alcohol extraction post-treatment such as the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Cortex Eucommiae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Fructus Chaenomelis, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Glycyrrhizaes, has the effect of benefiting QI for activating blood circulation, strong muscles and bones, the blood stasis dispelling that dispels the wind.Be used for the treatment of rheumatism, waist cervical spondylosis.
The effect of medicament of the present invention is: antibiotic, antiviral, reduction blood viscosity, microcirculation improvement, neuroprotective.Clinically invigorate blood circulation, detumescence, analgesic effect, and safe in utilization, be fit to the osteoarthritis patient and nurse one's health health, recover the dietetic therapy of function of joint, particularly be equipped with the Chinese liquor that is beneficial to relaxing muscles and tendons to promote blood circulation, instant effect, evident in efficacy.Be characterized in pure Chinese medicine,, and reach the good result of recovering function of human body by comprehensive conditioning human body with safety commonly used.
The specific embodiment
Below further sets forth the beneficial effect of medicine of the present invention by testing example, these are tested routine pharmacodynamics test, acute toxicity test and the clinical observation on the therapeutic effect of medicine of the present invention of having comprised and test.
Test example 1: the pharmacodynamics test of strong bone wine
Test material:
Medicine: strong bone wine, 500ml/ bottle (every 1ml contains crude drug 0.29g), lot number: 071026, provide by three true community medical service centers; Aspirin Enteric-coated Tablets, lot number: 060807, Shutaishen (Beijing) Pharmaceutical Co., Ltd. produces; Carrageenin, lot number: 110H3367, Sigma company produces.
Animal and instrument: cleaning level Kunming mouse, SD rat, wound laboratory animal science service portion provides by Changsha Kaifu District east; Laboratory animal production licence: SCXK (Hunan) 2006-0001 number; Institute for drug control, Hunan Province Animal House, laboratory animal occupancy permit: SYXK (Hunan) 2003-0006 number.YLS-7A toes volumetric measurement instrument, only the positive magnificent bio-instruments equipment company limited in north is produced; GJ-8402 hot plate dolorimeter, Bai Shi Electronic Instruments Plant in Zhejiang produces; TU-1901 dual-beam ultraviolet-uisible spectrophotometer, the Beijing Puxi General Instrument Co., Ltd produces.
Test method and result:
1, method for preparation of drug and laboratory animal grouping:
Laboratory animal generally is divided into five groups: first group is the normal control group, gives the equal-volume distilled water; Second group of positive medicine group; Third and fourth, five groups be respectively the strong high, medium and low dosage group of bone wine; Mice dosage is respectively 8.8,4.4,2.2g crude drug/kg, get 2 bottles of strong bone wine, i.e. 1000ml, water-bath is concentrated into 100ml, be that every 1ml contains crude drug 2.9g, the concentration that is made into 35.2g/100ml, 17.6g/100ml, 8.8g/100ml with strong bone wine concentrate adding distil water is respectively used for mice; (, being equivalent to 4 times, 2 times and 1 times of human dose,equivalent respectively) by body surface area; Rat dosage is respectively 6.0,3.0,1.5g crude drug/kg, get 2 bottles of strong bone wine, i.e. 1000ml, water-bath is concentrated into 100ml, be that every 1ml contains crude drug 2.9g, the concentration that is made into 0.30g/100ml, 0.15g/100ml, 0.075g/100ml with strong bone wine concentrate adding distil water is respectively used for rat; (, being equivalent to 4 times, 2 times and 1 times of human dose,equivalent respectively) by body surface area; (, being equivalent to 4 times, 2 times and 1 times of human dose,equivalent respectively) by body surface area; Positive drug aspirin tablet, the concentration that is made into 0.18g/100ml, 0.2g/100ml respectively with distilled water for rat and mice with (, being equivalent to 2 times of human dose,equivalent) by body surface area; The equal gastric infusion of all animals, mice administration volume is the 25ml/kg body weight, and rat administration volume is the 20ml/kg body weight, and the normal control group is given the equal-volume distilled water.Except as otherwise herein provided, be administered once general every day, and laboratory temperature is controlled at 18～28 ℃, and water is freely ingested, taken the photograph to self-control standard particle forage feed.
2, the antiinflammatory action of strong bone wine
1) to the influence of mouse peritoneal capillary permeability
50 of cleaning level Kunming mouses, male and female half and half, body weight 18～22g, be divided into five groups (n=10) at random, the positive drug aspirin tablet is pressed the method administration in 1, once a day, totally 7 days, administration the 7th day, behind the last administration 40min, equal intravenous injection 1% azovan blue of each Mus (0.1ml/g), lumbar injection 0.6% acetic acid (0.2ml/ is only) immediately, behind the 20min, take off cervical vertebra and put to death,, draw cleaning mixture (about 3～4ml) and move in the test tube with syringe with 5ml normal saline flushing abdominal cavity.Cleaning mixture is carried out the centrifugal 5min of 1000rpm, get supernatant and measure absorbance (A) at the 590nm place.The results are shown in Table 1.
The strong bone wine of table 1 to the influence of mouse peritoneal capillary permeability (
N=10)
Compare * P＞0.05 * * P＜0.05 * * * P＜0.01 with model control group
The result shows, strong bone wine height, in two dosage groups and positive drug group can obviously suppress the increase of the mouse peritoneal capillary permeability that acetic acid causes, but the low dose group effect is not obvious.
2) influence of rat paw edema due to the on Carrageenan
50 of cleaning level SD rats, male, body weight 160～180g, be divided into five groups (n=10) at random, the positive drug aspirin tablet is pressed the method administration in 1, once a day, totally 7 days, administration the 7th day, behind the last administration 1.0h, only in the subcutaneous injection 1% carrageenin 0.1ml/ of the right back sufficient sole of the foot of rat, 1.0h, the 2.0h, 3.0h, 4.0h, 5.0h, the 6.0h that cause after the inflammation measure the rat paw volume respectively, calculate swelling degree value (cause scorching metapedes sole of the foot volume and cause the poor of scorching front foot sole of the foot volume).The results are shown in Table 2.
The influence of rat paw edema due to the strong bone wine on Carrageenan of table 2 (
N=10)
Compare * P＞0.05 * * P＜0.05 * * * P＜0.01 with model control group
The result shows, strong bone wine height, in two dosage group 3.0h, 4.0h, 5.0h, 6.0h can obviously suppress the rat paw edema that carrageenin causes, its swelling rate is starkly lower than model control group.
3, the analgesic activity of strong bone wine
1) Dichlorodiphenyl Acetate causes the influence of pain mouse writhing number of times
50 of cleaning level Kunming mouses, male and female half and half, body weight 18～22g, be divided into five groups (n=10) at random, the positive drug aspirin tablet is pressed the method administration in 1, once a day, totally 7 days, administration the 7th day, except that the normal control group, behind the last administration 60min, lumbar injection 0.7% glacial acetic acid (0.15ml/10g), that observes that every mice 15min endogenous cause of ill pain causes turns round the body number of times.The results are shown in Table 3.
The strong bone wine Dichlorodiphenyl Acetate of table 3 cause the pain white mice turn round the influence of body number of times (
N=10)
Compare * P＞0.05 * * P＜0.05 * * * P＜0.01 with model control group
The result shows, strong bone wine height, in two dosage groups can obviously suppress the increase that acetic acid causes pain mouse writhing number of times, low dose group only suppresses acetic acid and causes the trend that pain mouse writhing number of times increases.
2) to the influence of thermostimulation mice pain reaction
Screen qualified mice: hot plate temperature is constant in (55 ± 0.5) ℃, behind the 10min, gets the female cleaning level of body weight 18～22g Kunming mouse number.Allly lick the metapedes time and give it up less than 5s or greater than 30s or leaper.Select 50 of qualified mices, be divided into five groups (n=10) at random, survey its normal pain threshold, as pain threshold before this Mus administration.The positive drug aspirin tablet is by the method administration in 1, after the administration 30,60,90min surveys the mice pain threshold respectively.The results are shown in Table 4.
The strong bone wine of table 4 to the influence of thermostimulation mice pain reaction (
N=10)
Compare * P＞0.05 * * P＜0.05 * * * P＜0.01 with model control group
The result shows, strong bone wine height, in two dosage groups and positive drug group can obviously improve the pain threshold of thermostimulation mice, low dose group only shows the trend that improves thermostimulation mice pain threshold.
The results of pharmacodynamic test of strong bone wine shows: strong bone drinking utensils has tangible antiinflammatory action.High, in due to two dosage group on Carrageenan rat paw edema significant inhibitory effect is also arranged; Strong bone wine height, in the mouse peritoneal capillary permeability that causes of two dosage group Dichlorodiphenyl Acetates increase the obvious suppression effect arranged.Strong bone drinking utensils has significant analgesia role.High, in two dosage groups can significantly reduce the number of times that acetic acid causes the pain mouse writhing, improve the pain threshold of mice to hot plate method.Above-mentioned pharmacological action is that the strong bone wine dipper of clinical practice has supplied experimental basis.
Test example 2: the acute toxicity test of strong bone wine
The mice maximum dosage-feeding of strong bone wine is 232g crude drug/kg, is equivalent to 960 times of 60 kilograms of clinical consumption per days of adult, and the strong clinical use of bone wine of prompting is safe.
Test material:
Medicine: strong bone wine, specification: the 500ml/ bottle, every 1ml contains crude drug 0.29g, lot number: 071026, provide by three true community medical service centers.Get 2 bottles of strong bone wine, i.e. 1000ml, water-bath is concentrated into 100ml, and promptly every 1ml contains crude drug 2.9g, and this concentration is Cmax.
Animal: Kunming mouse, 18～22g, 50, male and female half and half, wound laboratory animal science service portion provides by Changsha Kaifu District east; Laboratory animal production licence: SCXK (Hunan) 2006-0001 number.Institute for drug control, Hunan Province Animal House, laboratory animal occupancy permit: SYXK (Hunan) 2003-0006 number.18～28 ℃ of laboratory temperatures, water is freely ingested, taken the photograph to self-control standard particle forage feed.
Test method and result:
Through 10 mice preruns, ig can not survey LD
50So, carry out maximum dosage-feeding and measure.
Get 40 of mices, 20～22g, male and female half and half are divided into two groups (n=20), administration group and matched group.Every eating not water proof after 12 hours, the administration treated animal is irritated the Weishang and is stated strong bone wine concentrated solution 0.8ml/20g, control animals is irritated stomach equal-volume water for injection, each 12 hours at interval, be total to the administration secondary, observe the toxic reaction of 7 days animals after the administration continuously, comprise behavioral activity, the mental status, appetite, defecation, and hair, breathing, mouth, nose, eye, ear, anus etc. have or not situations such as abnormal secretion thing, body weight change and death.The results are shown in Table 5, except that administration treated animal activity slightly reduces after administration, other there is no unusually.Animal all survives, and the matched group weight average increases by 16.8%, and administration group weight average increases by 16.4%.Put to death mice on the 8th day and dissect, main organs such as the perusal heart, liver, spleen, lung, kidney, it is unusual with tangent plane to there is no the surface.Strong bone wine maximum dosage-feeding every day of mice ig is 232g crude drug/kg as a result, be equivalent to clinical 60 kilograms of adult's one consumption per days (50ml/ day, 50 * 0.29/60=0.242g crude drug //kg) 960 times.
The strong bone wine acute toxicity test in mice of table 5 is table as a result
The result shows, is good for bone wine mouse stomach 232g crude drug/kg, is equivalent to 960 times of clinical 60 kilograms of adult's one consumption per days (50ml/ day, 50 * 0.29=0.242g crude drug), and prompting this product toxicity is little, and it is safe using under the dosage of clinical recommendation.
The present invention is clinical be used for rheumatism foot pain, lumbago, scapulohumeral periarthritis amounts to hundreds of examples that specially good effect is arranged, find lumbar spondylosis, cervical spondylosis, evident in efficacy are had no adverse reaction in the back.
Test example 3: clinical observation
1) there is the patient to reflect to take strong bone trick after drinking to have heating sense person curative effect faster and better; 2) there is the rheumatism effect that slipping expands feels more obvious; 3) allly take a week person of taking effect, continue to take substantially and can cure fully, but need consolidate the course of treatment by season.4) this product is used for rheumatism to treat little arthralgia (finger, toe joint) curative effect not good enough; 5) treatment cervical spondylosis, lumbar spondylosis (cooperation traction curative effect is better) is generally taken and can be seen a curative effect in month.Can adhere to continuing to take 2～3 months, but significant curative effect.Treatment waist cervical spondylosis can be taken 4～20 bottles of this product according to the weight of the state of an illness, the length of disease time.
Liao * * worker of Hunan Children Hospital had cervical spondylosis C4, C5, C6 hyperosteogeny of cervical vertebra in 45 years old.Pain in hand, numbness of hand, neck pain, take 4 bottles of (50ml/ time) backs of strong bone wine pain relief, migration, adhere to taking and amount to 12 bottles of basic healings, clinical symptoms all disappears.
Liu * * 38 years old lumbago of man had a surplus and take 3 bottles of strong bone wine, cure in 2 months.
Old * *, the woman, 41 years old, in morbidity in 1994,, Annex II institute expert diagnosis attached through lake medical university was rheumatism, and once hospitalization began to take strong bone wine in October, 2000, and symptom be two knee joint pain at that time, had that slipping expands feels, and both hands are weak, can not drain clothes.Morning, finger had stiff sense, taking strong bone wine 1 bottle (500 milliliters) is clearly better, pain relief, hands is weak, and stiff sense disappears, continue to take strong bone wine, in February calendar year 2001 all symptoms all disappear, clinically cure the 1 bottle of after treatment of every month prone period of spring, so far not recurrence, the healthy operate as normal of energy, life.
Zhou Yun, the man, 43 years old, rheumatic arthritis was suffered from existing 15 years by Yun Xi village in Zhuzhou, began to take strong bone wine in June, 2000.Double-legged at that time knee joint and following position to toe swelling has half a year, want the both hands supplemental support just can stand, go to toilet and can not squat down, the strong bone wine of clothes begins detumescence after 3 days, after 1 month, the detumescence of 95% position, pain relief, after continue to take totally 8 bottles of strong bone wine, on October 1st, 2000, pay a return visit recovery from illness, can carry on a shoulder pole 140 jin of tea sons.
Come further to set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1
10 parts of the Radix Paeoniae Albas, 10 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Polygoni Cuspidati add in the wine and soaked 15 days, make the Chinese medicine medicated wine.
Embodiment 2
30 parts of the Radix Paeoniae Albas, 30 parts of Radix Angelicae Sinensis, 30 parts of Rhizoma Polygoni Cuspidati add water extraction, make middle medicament.
Embodiment 3
The wine extraction thing or the water extract of 15 parts of the Radix Paeoniae Albas, 20 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Polygoni Cuspidati, the tablet manufacture method is processed into Chinese medicinal tablet routinely.
Embodiment 4
20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 20 parts of the Cortexs Eucommiae, 20 parts of Radix Achyranthis Bidentataes, 10 parts of Fructus Chaenomeliss, 20 parts of the Radix Paeoniae Albas, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts in Radix Glycyrrhizae added soaking in Chinese liquor 15 days, made the Chinese medicine medicated wine.
Embodiment 5
20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of the Cortexs Eucommiae, 10 parts on Flos Carthami, 10 parts of Radix Clematidis, 20 parts of the Radix Paeoniae Albas, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts in Radix Glycyrrhizae, 10 parts of Radix Achyranthis Bidentataes, 10 parts of Fructus Chaenomeliss added soaking in Chinese liquor 15 days, made the Chinese medicine medicated wine.
Embodiment 6
Wine extraction thing and the water extract of 20 parts of the Radixs Astragali, 20 parts of Radix Angelicae Sinensis, 10 parts of the Cortexs Eucommiae, 10 parts of Radix Achyranthis Bidentataes, 10 parts of Fructus Chaenomeliss, 10 parts of the Radix Paeoniae Albas, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts in Radix Glycyrrhizae, the tablet manufacture method is processed into Chinese medicinal tablet routinely.
Embodiment 7
Wine extraction thing and the water extract of 20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of the Cortexs Eucommiae, 10 parts on Flos Carthami, 10 parts of Radix Clematidis, 20 parts of the Radix Paeoniae Albas, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts in Radix Glycyrrhizae, 10 parts of Radix Achyranthis Bidentataes, 10 parts of Fructus Chaenomeliss, the tablet manufacture method is processed into Chinese medicinal tablet routinely.
Claims (5)
1. medicament that is used for the treatment of rheumatism, waist cervical spondylosis is characterized in that it is mainly made by water or alcohol extraction by following bulk drugs: Radix Paeoniae Alba 5-30 part, Rhizoma Polygoni Cuspidati 5-30 part, Radix Angelicae Sinensis 5-30 part.
2. the medicament that is used for the treatment of rheumatism, waist cervical spondylosis according to one kind of claim 1 is characterized in that described medicament is medicated wine, capsule, pill, tablet or mixture.
3. the medicament that is used for the treatment of rheumatism, waist cervical spondylosis according to one kind of claim 2 is characterized in that described medicated wine is that crude drug was made with soaking in Chinese liquor in 15～30 days.
4. according to claim 1 or 2 or 3 one kind of medicament that is used for the treatment of rheumatism, waist cervical spondylosis, it is characterized in that described medicament also will add: Radix Astragali 5-30 part, Cortex Eucommiae 5-30 part, Radix Achyranthis Bidentatae 5-30 part, Fructus Chaenomelis 5-30 part, Radix Glycyrrhizae 5-30 part.
5. according to claim 1 or 2 or 3 one kind of medicament that is used for the treatment of rheumatism, waist cervical spondylosis, it is characterized in that described medicament also will add: Radix Astragali 5-30 part, Cortex Eucommiae 5-30 part, Flos Carthami 5-30 part, Radix Clematidis 5-30 part, Radix Glycyrrhizae 5-30 part, Rhizoma Atractylodis Macrocephalae 5-30 part, Radix Achyranthis Bidentatae 5-30 part, Fructus Chaenomelis 5-30 part.
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| CN102327380B (en) * | 2011-10-22 | 2014-09-24 | 李进峰 | Chinese medicinal composition for treating knee osteoarthritis |
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| CN105250670A (en) * | 2015-11-07 | 2016-01-20 | 黑龙江省农业科学院畜牧研究所 | Traditional Chinese medicine composition for treating Min pig arthritis as well as preparation method and application thereof |
| CN107551092A (en) * | 2016-07-01 | 2018-01-09 | 陈立云 | A kind of exterior-applied medical wine for treating the elderly's pain in waist and lower extremities |
| CN108310264A (en) * | 2018-03-09 | 2018-07-24 | 李文本 | A kind of Chinese medicine composition for treating protrusion of lumber intervertebral disc sciatic nerve crush |
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