CN101190256B - Chuanqisan for treating cervical spondylopathy and preparation method - Google Patents

Abstract

The invention discloses a szehuan lovage root powdered medicine used for treating cervical spondylosis and the preparation method thereof, which is prepared according to proportion by tortoise plastron, suberect spatholobus stem, Danshen root, radix astragali, angelica, fortune's drynaria rhizome, eucommia bark, pyrite, szechuan lovage rhizome and himalayan teasel root processed respectively in advance. The invention has the functions of invigorating qi, activating blood circulation, soothing the veins, eliminating stasis and relieving pain. The medicine disclosed by the invention has the advantages of high curative effect, rapid effectiveness show, no toxic and side effect and low cost.

Description

A kind of river stilbene for the treatment of cervical spondylosis looses and preparation method

Technical field

The present invention relates to the preparation method of pharmaceutical composition and said composition, especially relate to the pharmaceutical composition and the preparation method for the treatment of cervical spondylosis.

Background technology

Cervical spondylosis is because the syndrome of degeneration of cervical intervertebral disc, the caused a series of clinical symptoms of hyperosteogeny of cervical vertebra.Can betide any age, be many with the middle-aged and elderly people more than 40 years old.This disease has the sickness rate height, and treatment time is long, characteristics such as recurrence very easily after the treatment.Cervical spondylosis is the root of multiple disease, its degeneration be one for a long time, process slowly, be not one day cold.The unusual numerous and complicated of the clinical manifestation of cervical spondylosis is varied.Its typical clinical symptoms mainly shows as: headache or migraine, dizziness, and can be with feeling sick, vomit, blurring of vision Chu, fuzzy, visual deterioration, platycoria or dwindle eyes rear portion distending pain, palpitate quickly, arrhythmia, precordialgia, hypertension, incidence and extremity are perspired unusually and tinnitus, auditory dysesthesia, dysphonia etc. also can show as dim eyesight, shed tears, complicated performances such as nasal obstruction, bradycardia, blood pressure drops, flatulence.At present the Drug therapy of cervical spondylosis is mainly taken Western medicine, generally takes medicines such as the aspirin that eases the pain, ibuprofen.It is fewer to cure treatment cervical spondylosis Chinese medicine, and therapeutic effect is unsatisfactory.

Summary of the invention

Purpose of the present invention is exactly the problem of effectively treating the Chinese medicine of cervical spondylosis at existing shortage, and good Chinese medicine composition of a kind of therapeutic effect and preparation method are provided.

Pharmaceutical composition of the present invention is made up of following bulk drugs:

Carapax et Plastrum Testudinis 25-35 part, Caulis Spatholobi 15-25 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Astragali 3-7 part, Radix Angelicae Sinensis 3-7 part, Rhizoma Drynariae 3-7 part, Cortex Eucommiae 3-7 part, Pyritum 7-11 part, Rhizoma Chuanxiong 2-6 part, Radix Dipsaci 3-7 part.

Wherein the optimum ratio of crude drug is:

30 parts of Carapax et Plastrum Testudiniss, 20 parts of Caulis Spatholobis, 12 parts of Radix Salviae Miltiorrhizaes, 5 parts of the Radixs Astragali, 5 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Drynariae, 5 parts of the Cortexs Eucommiae, 9 parts of Pyritums, 4 parts of Rhizoma Chuanxiongs, 5 parts of Radix Dipsacis.

Above crude drug is concocted separately, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Cortex Eucommiae, Rhizoma Drynariae, Radix Dipsaci Caulis Spatholobi are chosen decontamination, clean, moistening dries in the air slightly to inside and outside humidity when suitable, and section is dried, and is ground into carefully not; Carapax et Plastrum Testudinis is fried to shortcake degree of being with sand, taken out to clean and dry; With Pyritum, pound into fritter, to put on the smokeless stove fire or put and forge in the suitable container to dark red, quench in vinegar to surface is pitchy, and gloss disappears and is loose.Every Pyritum 100 grams are with vinegar 30 grams.

With the above crude drug that cooks, grind to form powder, evenly preparation in proportion, 200 orders that sieve are made the powder pack and are got final product.

In technical solution of the present invention, Carapax et Plastrum Testudinis replenishing kidney and strengthening bone, the reinforcing the heart of nourishing blood; The Caulis Spatholobi blood circulation promoting and enriching. relaxing muscles and tendons and activating QI and blood in the collateral; The Rhizoma Chuanxiong activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain; The Radix Dipsaci invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating; Rhizoma Drynariae the kidney invigorating bone strengthening continues and hinders pain relieving; The Pyritum eliminating stasis to stop pain, synthetism is cured the wound; Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening; The Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae compatibility have strengthened the effect of inrigorating qi and promoting blood circulation collateral dredging, stasis-dispelling and pain-killing; ,

The specific embodiment

Below further set forth the beneficial effect of medicine of the present invention by testing example.

The clinical observation of test example 1 Drug therapy cervical spondylosis of the present invention

1, physical data

This institute accepts cervical spondylosis patient 780 examples altogether for medical treatment, divides this medicine treatment group and matched group at random.Diagnostic criteria and therapeutic evaluation standard meet " disease of tcm diagnosis criterion of therapeutical effect " [1] regulation.The treatment group: take this medicament capsule, day clothes secondary, each 12 grams, light salt brine is taken after mixing it with water, and 30 days is a course of treatment.Matched group: take aspirin, ibuprofen etc.

(1) treatment group: in 480 examples, male 360 examples, women 120 examples.Age 35-55 year, 52 years old mean age.Trauma history 49 examples are arranged, course of disease January～December; Simple neck is takeed on 210 examples of aching; Merge headache and dizzy 120 examples; Merge disease of hand 110 examples; CT or MRI show outstanding in various degree 80 examples of cervical intervertebral disk.

(2) matched group: matched group 300 examples, male 202 examples, women 98 examples, age 35-55 year, average 53.4 years old.Trauma history 38 examples are arranged, 14 days～October of the course of disease; Simple neck is takeed on 180 examples of aching; Merge headache and dizzy 86 examples; Merge disease of hand 98 examples; CT or MRI show intervertebral disc protrusion of cervical vertebra 62 examples.

Two groups of patient ages, sex, state of an illness each side comparing differences do not have significance meaning (P＞0.05).

2, research method

(1) diagnostic criteria:

According to " disease of tcm diagnosis criterion of therapeutical effect " [1] regulation, clinical manifestation and the imageology finding person of being consistent can be made a definite diagnosis; Have typical cervical spondylosis clinical manifestation, and the normal person of imageology finding, other diagnosable cervical spondylosiss in sufferer rear except should noting; Only there is the imageology performance unusual, and do not have cervical spondylosis clinical symptoms person, should not diagnose cervical spondylosis.

(2) efficacy assessment standard

According to " disease of tcm diagnosis criterion of therapeutical effect " [1] regulation, clinical cure: symptom and sign complete obiteration; Take a turn for the better: cardinal symptom and sign disappear mostly, and the state of an illness takes an evident turn for the better, but the cervical region activity is still limited or sticky feeling arranged; Invalid: no change before and after subjective symptoms and the sign.

3, Therapeutic Method

In Primary Care, the treatment group: take this drug powder, day clothes secondary, each 12 grams, light salt brine is taken after mixing it with water, and 30 days is a course of treatment.Matched group: take aspirin, ibuprofen, 30 days is a course of treatment.Add up curative effect after two courses of treatment.

4, statistical method

T check before and after the treatment, The data (± S) expression.

5, result and analysis

(1) curative effect

The treatment group: this medication therapy groups 480 examples, cure 320 examples, 146 examples that take a turn for the better, invalid 14 examples, total effective rate 97%.Matched group: treat 300 examples, cure 150 examples, 91 examples that take a turn for the better, invalid 59 examples, total effective rate 80%.Treatment group curative effect obviously is better than matched group (P＜0.05).

Clinical symptoms is improved relatively before and after (2) two groups of treatments

Two groups of contrasts of table one cervical spondylosis observation of curative effect table

Two groups of results of cervical spondylosis learn by statistics and handle check P＜0.005, significant difference.

Blood flow changes relatively before and after (3) two groups of treatments

Full specific viscosity, packed cell volume, Fibrinogen after the treatment of treatment group is starkly lower than treatment preceding (P＜0.05～0.01).(P＜0.05) other laboratory indexes treatment front and back difference does not have significance (P＜0.05) before having only packed cell volume to be starkly lower than treatment after the treatment of control group.Illustrate that the improvement that stilbene diffusing hemorheology to the cervical spondylosis patient in this medicine river is learned index is better than matched group.

Hemorheology changes relatively before and after the table two liang group treatment

6, toxicity

In clinical observation 480 examples, randomly draw 256 examples and carry out liver function, blood routine examination, all no abnormal variation, illustrating behind this medicine of application does not have systemic adverse reactions.16% patient is only arranged, the sensation of gastral cavilty portion discomfort is arranged after taking medicine, change one after each meal into, uncomfortable positive shape can obviously alleviate.

7, model case:

ZhaoBing Lan, woman, teacher, 38 years old.First visit: neck, shoulder, backache, both hands torpor and swelling 7 wheat harvesting periods, it is invalid once to obey a large amount of Western medicine.The pain increased for nearly section, goes into Night Watch very, uneasy in either sitting or lying, restriction of neck motion.The left side Wry Neck, pain increased the weight of when cervical region was movable, and 4-7 cervical vertebra tenderness is obvious, pressure measurement by compression of neck (+), brachial plexus nerve distraction test (+).X-ray film shows: in neck 4-neck 7 vertebral body hyperosteogenys, bilateral uncovertebral joint gap is not wide.Take this medicine river stilbene after diffusing two courses of treatment, the symptom complete obiteration.

Zephyr, man, 54 years old, office worker.Patient's shoulder, neck, occipitalia pain is more than 2 years, headache dizzy half a year.The nearly section state of an illness increases the weight of, rigidity of the neck, and it is ineffective to change one's position, blurring of vision, often the occurrence positions vertigo is invalid through western medicines in treatment, satisfies and comes the diagnosis and treatment of this institute.Check diagnosis: 3～7 cervical spine tenderness are obvious, and the brachial plexus distraction test pushes up test with kowtowing, and all is positive.The X-ray sheet shows: cervical curvature becomes straight, and C3, C4, C5 anterior margin of vertebral body are lips and teeth sample hypertrophy, C5～C6 stenosis of disc space.Take this medicine river stilbene after diffusing two courses of treatment, all symptoms are all eliminated, and neck and limb function activity full recovery are normal, and following up a case by regular visits to did not have recurrence in 2 years.

Come further to set forth the preparation method of medicine of the present invention by the following examples

Embodiment one:

Get Carapax et Plastrum Testudinis 300 grams, Caulis Spatholobi 200 grams, Radix Salviae Miltiorrhizae 120 grams, the Radix Astragali 50 grams, Radix Angelicae Sinensis 50 grams, Rhizoma Drynariae 50 grams, the Cortex Eucommiae 50 grams, Pyritum 90 grams, Rhizoma Chuanxiong 40 grams, Radix Dipsaci 50 grams.

Above crude drug is concocted separately, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Cortex Eucommiae, Rhizoma Drynariae, Radix Dipsaci Caulis Spatholobi are chosen decontamination, clean, moistening dries in the air slightly to inside and outside humidity when suitable, and section is dried, and is ground into carefully not;

Carapax et Plastrum Testudinis is fried to shortcake degree of being with sand, taken out to clean and dry; With Pyritum, pound into fritter, to put on the smokeless stove fire or put and forge in the suitable container to dark red, quench in vinegar to surface is pitchy, and gloss disappears and is loose.Every Pyritum 100 grams are with vinegar 30 grams.With the above crude drug that cooks, grind to form powder, evenly preparation in proportion, 200 orders that sieve are made powder, every bag 6 gram, each 2 bags, day clothes secondary.

Claims (3)

1. a river stilbene for the treatment of cervical spondylosis looses, and it is characterized in that this pharmaceutical composition river stilbene looses to be made by weight by following bulk drugs: Carapax et Plastrum Testudinis 25-35 part, Caulis Spatholobi 15-25 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Astragali 3-7 part, Radix Angelicae Sinensis 3-7 part, Rhizoma Drynariae 3-7 part, Cortex Eucommiae 3-7 part, Pyritum 7-11 part, Rhizoma Chuanxiong 2-6 part, Radix Dipsaci 3-7 part.

2. river according to claim 1 stilbene looses, and it is characterized in that this river stilbene looses to be made by weight by following bulk drugs: 30 parts of Carapax et Plastrum Testudiniss, 20 parts of Caulis Spatholobis, 12 parts of Radix Salviae Miltiorrhizaes, 5 parts of the Radixs Astragali, 5 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Drynariae, 5 parts of the Cortexs Eucommiae, 9 parts of Pyritums, 4 parts of Rhizoma Chuanxiongs, 5 parts of Radix Dipsacis.

3. a kind of river stilbene for the treatment of cervical spondylosis according to claim 1 and 2 looses, it is characterized in that the preparation method that the river stilbene looses is: above crude drug is concocted separately, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Cortex Eucommiae, Rhizoma Drynariae, Radix Dipsaci, Caulis Spatholobi are chosen decontamination, clean, moistening, dry in the air slightly to inside and outside humidity when suitable, section is dried, pulverization; Carapax et Plastrum Testudinis is fried to shortcake degree of being with sand, taken out to clean and dry; With Pyritum, pound into fritter, put on the smokeless stove fire or put and forge in the suitable container to dark red, quench in vinegar to surface is pitchy, gloss disappears and is loose, every Pyritum 100 grams are with vinegar 30 grams, with the above crude drug that cooks, grind into powder, evenly preparation in proportion, 200 orders that sieve are made the powder pack and are got final product.