CN102370688B - A kind of compound Chinese medicinal preparation for treating osteoproliferation and preparation method thereof - Google Patents
A kind of compound Chinese medicinal preparation for treating osteoproliferation and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese traditional compound medicine for treating osteoproliferation, includes the Chinese medicine material that following weight matches：Pueraria lobata 13 17, radix astragali 8 12, Angelica sinensis 8 12, Ligusticum wallichii 8 12, earthworm 8 12, cassia twig 79, Radix Paeoniae Alba 79, the root of Chinese clematis 46, radix glycyrrhizae 46；Its preparation method is to clean above-mentioned 9 taste medicinal material, mix in proportion, 46 times of the water or volume ratio of dosing material gross weight be 70% ethanol decoct 2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrate, the liquid extract that proportion at 60 DEG C is 1.09 is obtained, using conventional fabrication process, Chinese medicine preparation of the present invention can be made into formulation described in any type pharmacy, such as tablet, capsule, granule, oral liquid, pill, syrup.The efficacy of a drug of the present invention is lasting, and drug effect is gentle, evident in efficacy, safe, particularly suitable for middle-older patient, is worth clinically applying and promoting.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation for treating osteoproliferation and preparation method thereof, belongs to field of traditional Chinese.
Background technology
Osteoproliferation（Also known as spur, spur or bone wart）And Hypertrophic arthropathy, it is a kind of common degeneration disease of human body
Disease, it is considered that pathogenic factor is mainly related with chronic injury and strain and senile degenerative change.This disease is mainly in
After the prime of life and the elderly, according to the data of the World Health Organization, osteoporosis is global health problem, its seriousness is only
Inferior to cardiovascular disease, threaten and be more than the common diseases such as breast cancer, prostate cancer.In global more than 50 years old old man, 1/3 women and 1/
5 male is subject to osteoporosis to threaten.Age of onset has gradual rejuvenation trend again in recent years, and osteoproliferation has caused more next
More attention.
Although treating up to 145 kinds of the Chinese medicine of hyperostosis, frequency of use the higher person is simultaneously few, these medicines are many
More scholars repeat to use, and illustrate that it can not despise this sick effect, therefore should pay attention to studying it
, composition 1 or higher prescription of several the effect of being relatively fixed, to be promoted the use of in wider scope.
The content of the invention
It is an object of the invention to provide a kind of Chinese traditional compound medicine for treating osteoproliferation and preparation method thereof.
The present invention is provided in a kind of pueraria lobata, radix astragali, Angelica sinensis, Ligusticum wallichii, earthworm, cassia twig, Radix Paeoniae Alba, the root of Chinese clematis, radix glycyrrhizae compatibility
Medicine compound preparation is used to treat osteoproliferation, and curative effect is higher, and therapeutic domain is wide, particularly suitable for middle-older patient, is worth facing
Apply and promote on bed.
Technical solution of the present invention is as follows：
A kind of Chinese traditional compound medicine for treating osteoproliferation, includes the Chinese medicine material of following weight proportioning：Pueraria lobata 13-17,
Radix astragali 8-12, Angelica sinensis 8-12, Ligusticum wallichii 8-12, earthworm 8-12, cassia twig 7-9, Radix Paeoniae Alba 7-9, root of Chinese clematis 4-6, radix glycyrrhizae 4-6.
Wherein preparation method is to clean above-mentioned 9 taste medicinal material, is mixed in proportion, 4-6 times of water of dosing material gross weight or
The ethanol that volume ratio is 70% decocts 2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrates, proportion is when obtaining 60 DEG C
1.09 liquid extract, using conventional fabrication process, Chinese medicine preparation of the present invention can be made into formulation described in any type pharmacy,
Such as tablet, capsule, granule, oral liquid, pill, syrup.
Chinese traditional compound medicine produced by the present invention is with qi and activate blood circulation, reinforcing kidney and strengthening resistance, and based on warming and activating meridian analgesic, all medicines close
With the efficacy of a drug is lasting, and drug effect is gentle, evident in efficacy, safe, particularly suitable for middle-older patient, is worth clinically applying
And popularization.
Specific embodiment
Embodiment 1：
A kind of Chinese traditional compound medicine for treating osteoproliferation, includes the Chinese medicine material of following weight proportioning：Pueraria lobata 13, radix astragali
8th, Angelica sinensis 8, Ligusticum wallichii 8, earthworm 8, cassia twig 7, Radix Paeoniae Alba 7, the root of Chinese clematis 4, radix glycyrrhizae 4.
Wherein preparation method is to clean above-mentioned 9 taste medicinal material, is mixed in proportion, and 4 times of water of dosing material gross weight decocts 2
It is secondary, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrates, and obtains the liquid extract that proportion at 60 DEG C is 1.09.
Embodiment 2：
A kind of Chinese traditional compound medicine for treating osteoproliferation, includes the Chinese medicine material of following weight proportioning：Pueraria lobata 15, radix astragali
10th, Angelica sinensis 10, Ligusticum wallichii 10, earthworm 10, cassia twig 8, Radix Paeoniae Alba 8, the root of Chinese clematis 5, radix glycyrrhizae 5.
Remaining is the same as embodiment 1.
Embodiment 3：
A kind of Chinese traditional compound medicine for treating osteoproliferation, includes the Chinese medicine material of following weight proportioning：Pueraria lobata 17, radix astragali
12nd, Angelica sinensis 12, Ligusticum wallichii 12, earthworm 12, cassia twig 9, Radix Paeoniae Alba 9, the root of Chinese clematis 6, radix glycyrrhizae 6.
Wherein preparation method is to clean above-mentioned 9 taste medicinal material, is mixed in proportion, and 4 times of volume ratios of dosing material gross weight are
70% ethanol decocts 2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrate, obtain the stream that proportion at 60 DEG C is 1.09
Medicinal extract.
Embodiment 4：
A kind of Chinese traditional compound medicine for treating osteoproliferation, wherein preparation method are to clean the medicinal material in formula, by than
Example mixing, the ethanol that 5 times of volume ratios of dosing material gross weight are 70% decoct 2 times, every time 1 it is small when, merge 2 decoction liquors, mistake
Filter, and concentrate, obtain the liquid extract that proportion at 60 DEG C is 1.09.
Remaining is the same as embodiment 1.
Embodiment 5：
A kind of Chinese traditional compound medicine for treating osteoproliferation, wherein preparation method are to clean the medicinal material in formula, by than
Example mixing, 5 times of water of dosing material gross weight decoct 2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrate, obtain
Proportion is 1.09 liquid extract at 60 DEG C.
Remaining is the same as embodiment 2.
Embodiment 6：
A kind of Chinese traditional compound medicine for treating osteoproliferation, wherein preparation method are to clean the medicinal material in formula, by than
Example mixing, 5 times of water of dosing material gross weight decoct 2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrate, obtain
Proportion is 1.09 liquid extract at 60 DEG C.
Remaining is the same as embodiment 3.
Embodiment 7：
A kind of Chinese traditional compound medicine for treating osteoproliferation, wherein preparation method are to clean the medicinal material in formula, by than
Example mixing, the ethanol that 6 times of volume ratios of dosing material gross weight are 70% decoct 2 times, every time 1 it is small when, merge 2 decoction liquors, mistake
Filter, and concentrate, obtain the liquid extract that proportion at 60 DEG C is 1.09.
Remaining is the same as embodiment 2.
Embodiment 8：
A kind of Chinese traditional compound medicine for treating osteoproliferation, includes the Chinese medicine material of following weight proportioning：Pueraria lobata 18, radix astragali
15th, Angelica sinensis 15, Ligusticum wallichii 15, earthworm 5, cassia twig 5, Radix Paeoniae Alba 5, the root of Chinese clematis 2, radix glycyrrhizae 2.
Wherein preparation method is to clean the medicinal material in formula, is mixed in proportion, and 6 times of water of dosing material gross weight decocts
2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrates, and obtains the liquid extract that proportion at 60 DEG C is 1.09.
Embodiment 9：
A kind of Chinese traditional compound medicine for treating osteoproliferation, includes the Chinese medicine material of following weight proportioning：Pueraria lobata 10, radix astragali
5th, Angelica sinensis 5, Ligusticum wallichii 8, earthworm 12, cassia twig 10, Radix Paeoniae Alba 10, the root of Chinese clematis 10, radix glycyrrhizae 10.
Wherein preparation method is to clean the medicinal material in formula, is mixed in proportion, and 6 times of volume ratios of dosing material gross weight are
70% ethanol decocts 2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrate, obtain the stream that proportion at 60 DEG C is 1.09
Medicinal extract.
Embodiment 10：
A kind of Chinese traditional compound medicine for treating osteoproliferation, includes the Chinese medicine material of following weight proportioning：Pueraria lobata 18, radix astragali
8th, Angelica sinensis 13, Ligusticum wallichii 7, earthworm 13, cassia twig 3, Radix Paeoniae Alba 10, the root of Chinese clematis 3, radix glycyrrhizae 7.
Wherein preparation method is to clean above-mentioned 9 taste medicinal material, is mixed in proportion, and 7 times of 7 volume ratio of dosing material gross weight is
70% ethanol decocts 2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrate, obtain the stream that proportion at 60 DEG C is 1.09
Medicinal extract.
Embodiment 11：
A kind of Chinese medicine preparation of cleaning moisture and dispelling cold according to disclosed in the patent of Application No. 200610104351.2, including it is following
Drug matching：Pueraria lobata 20g, cassia twig 8g, Radix Paeoniae Alba 15g, ginger 10g, radix astragali 20g, 10 pieces of jujube, moxibustion radix glycyrrhizae 6g, full worm 6g, earthworm
10g, safflower 20g, rhizoma atractylodis 12g, reticulate millettia 10g, root of Chinese clematis 10g, vomiting nut 10g, myrrh 10g, zaocys dhumnade 10g, rhizoma cibotii 35g,
Folium artemisiae argyi 10g, Angelica sinensis 10g, borneol 30g, notopterygium root 20g, levisticum 15g, pericarpium zanthoxyli 200g, radix glycyrrhizae 10g, Ligusticum wallichii 10g, root of Dahurain angelica 20g, asarum
10g。
Wherein preparation method is that above-mentioned processing of crude drugs is processed with white wine and vinegar and formed, coordinate thermotherapy treatment to make into smalls
With.
Embodiment 12：
A kind of medicine for treating osteoproliferation according to disclosed in the patent of Publication No. CN 1173363A, including it is following heavy
Measure the Chinese medicine material of proportioning：18 parts of radix astragali, 18 parts of safflower, 21 parts of lanatechead saussurea herb with flower, 6 parts of dragon's blood, 18 parts of pueraria lobata, 18 parts of Ramulus Taxilli,
18 parts of the rhizome of davallia, play both sides of the street 18 parts, 18 parts of wild aconite root, 18 parts of aconiti preparata,radix, 18 parts of radix cyathulae, 6 parts of first pearl.
Wherein preparation method is that selected, drying, crushes respectively, is uniformly mixed, further crushes, mistake by above-mentioned medicinal material
100 mesh sieves, it is encapsulated to enter capsule machine, to obtain the final product.Take orally once a grain, three times per day.
Embodiment 13：Using conventional fabrication process, Chinese medicine preparation of the present invention can be made into any type pharmacy described
Formulation, such as tablet, capsule, granule, oral liquid, pill, syrup.
Remaining is the same as embodiment 1-10.
Embodiment 14：The liquid extract being uniformly mixed as made from embodiment 1-10 is concentrated, according to the operation of conventional tablet
Method, adds pharmaceutic adjuvant, each component is uniformly mixed, wet granulation, sieves, piece is made using conventional tablet the preparation method tabletting
The content of agent, wherein each component is as follows：
Ingredients Weight（Part）
Mix liquid extract 50
Starch 18
Microcrystalline cellulose 10
Talcum powder 10
Polyethylene glycol 5
Remaining is the same as embodiment 1-10.
Embodiment 15：The liquid extract being uniformly mixed as made from embodiment 1-10 is concentrated, according to the behaviour of conventional capsule
Make method, add pharmaceutic adjuvant, each component is uniformly mixed, pelletize, capsule is made using the filling of conventional capsule the preparation method,
The content of wherein each component is as follows：
Ingredients Weight（Part）
Mix liquid extract 100
Pregelatinized starch 26
Lactis Anhydrous 15
Microcrystalline cellulose 15
Calcium monohydrogen phosphate 8
Remaining is the same as embodiment 1-10.
Embodiment 16：The liquid extract being uniformly mixed as made from embodiment 1-10 is concentrated, according to the behaviour of traditional oral liquid
Make method, ethanol precipitation 1-2 times, is filtered, concentration, aqueous precipitation, filtering, adds pharmaceutic adjuvant, filtering, packing sterilizing, uses
Traditional oral liquid the preparation method prepares oral liquid, and the content of wherein each component is as follows：
Ingredients Weight（Part）
Mix liquid extract 100
Ethanol 150
Sucrose 85
Sodium carboxymethylcellulose 13
Peppermint oil 6
Sorbic acid 3
Remaining is the same as embodiment 1-10.
Effectiveness study is tested：
Patient data：
Articulatio genus hyperosteogeny 117, lumbar vertebrae hyperosteogeny 91, cervical vertebrae hyperosteogeny 91 are chosen in various big hospital.
Totally 299 patients, wherein man 161, female 138.Max age 69 years old, minimal ages 33 years old, average age 48.7 years old.It is most long
The course of disease 13 years, the most short course of disease 6 months, average course of disease 5.6 years.Clinical manifestation：There is chronic ache at most of morbidity position,
Part cervical vertebra hyperplasia patient, there is the radiated pain of dorsocephalad, and increases with the abnormal sensories such as cold and numbness, small part cervical vertebra
Raw patient has vegetative nerve functional disturbance, such as nausea, dizzy, tinnitus symptom.In addition some patientss painful area has
Obvious muscle spasmus or muscle tonue.
Treatment method：
299 patients are divided into 13 groups, wherein every group has an articulatio genus hyperosteogeny 9, lumbar vertebrae hyperosteogeny 7,
Cervical vertebrae hyperosteogeny 7；In 13 groups 1 group as a control group, 12 groups are used as treatment group.Control group takes GUCIPING PIAN, one time 5
Piece, 3 times a day；Chinese medical concrete made from embodiment 1-10 is diluted 11 times with water by volume, is taken respectively to 10 groups for the treatment of groups
With a 100ml, 3 times a day, remaining Liang Zu treatment groups are utilized respectively drug therapy made from embodiment 11 and embodiment 12；
Control group and treatment group all continuously treat 6 months.
Therapeutic evaluation：
It is divided into invalid, effective, notable, recovery from illness.Effective percentage plus notable rate add cure rate to be total effective rate.It is 1. invalid：Treatment
Front and rear sings and symptoms is not any change, or aggravation.It is 2. effective：The improvement of symptom and sign limited extent, function have
The recovery of limit degree.It is 3. notable：Symptom and sign disappear substantially, and functional rehabilitation is normal, but because Changes in weather or fatigue etc. still can
There is sense of discomfort.4. fully recover：Symptom and sign are wholly absent, and function recovers normal completely.
1 each group therapeutic effect of table counts
From efficacy experiment as can be seen that curative effect of the present invention is more than other treatment medicine, and match somebody with somebody better than similar in the prior art
Made from side the effect of Chinese medicine, especially with the best results of embodiment 5, therefore this efficacy of a drug is lasting, and drug effect is gentle, curative effect
Significantly, it is safe, particularly suitable for middle-older patient, it is worth clinically applying and promoting.
Claims (1)
1. a kind of Chinese traditional compound medicine for treating osteoproliferation, the Chinese medicine matched by following weight forms：Pueraria lobata 15, radix astragali 10,
Angelica sinensis 10, Ligusticum wallichii 10, earthworm 10, cassia twig 8, Radix Paeoniae Alba 8, the root of Chinese clematis 5, radix glycyrrhizae 5；Preparation method：To clean 9 taste medicinal materials, by than
Example mixing, 5 times of water of dosing material gross weight decoct 2 times, every time 1 it is small when, merge 2 decoction liquors, filtering, and concentrate, obtain
Proportion is 1.09 liquid extract at 60 DEG C, and using conventional fabrication process, above-mentioned Chinese medicine preparation is made in any type pharmacy
Described formulation, including tablet, capsule, granule, oral liquid, pill or syrup.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110364279.8A CN102370688B (en) | 2011-11-17 | 2011-11-17 | A kind of compound Chinese medicinal preparation for treating osteoproliferation and preparation method thereof |
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| CN201110364279.8A CN102370688B (en) | 2011-11-17 | 2011-11-17 | A kind of compound Chinese medicinal preparation for treating osteoproliferation and preparation method thereof |
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| CN102370688B true CN102370688B (en) | 2018-04-27 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103599233B (en) * | 2013-11-16 | 2015-05-13 | 李培良 | Bone hyperplasia rehabilitation medicinal liquor |
| CN103961424B (en) * | 2014-06-04 | 2016-06-01 | 杜黎明 | A kind of treat the Chinese medicine formula of cervical spondylosis and the preparation method of capsule preparations thereof |
| CN111773268A (en) * | 2020-08-04 | 2020-10-16 | 曹崇维 | External ointment for treating hyperosteogeny |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031186A (en) * | 1988-03-29 | 1989-02-22 | 吴大勇 | The prescription and the facture of specially good effect bony spur antiphlogistine |
| CN1150910A (en) * | 1996-04-18 | 1997-06-04 | 花茂时 | Osteophytosis pill and its compounding method |
| CN101121017A (en) * | 2006-08-09 | 2008-02-13 | 张跃进 | Traditional Chinese medicine formula for cleaning moisture and dispelling cold |
| CN101406645A (en) * | 2008-11-21 | 2009-04-15 | 张云庆 | Chinese medicinal composition for hyperosteogeny |
-
2011
- 2011-11-17 CN CN201110364279.8A patent/CN102370688B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031186A (en) * | 1988-03-29 | 1989-02-22 | 吴大勇 | The prescription and the facture of specially good effect bony spur antiphlogistine |
| CN1150910A (en) * | 1996-04-18 | 1997-06-04 | 花茂时 | Osteophytosis pill and its compounding method |
| CN101121017A (en) * | 2006-08-09 | 2008-02-13 | 张跃进 | Traditional Chinese medicine formula for cleaning moisture and dispelling cold |
| CN101406645A (en) * | 2008-11-21 | 2009-04-15 | 张云庆 | Chinese medicinal composition for hyperosteogeny |
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