CN115068401A

CN115068401A - Long-acting oil-control plump and fluffy bionic amino acid shampoo and preparation method thereof

Info

Publication number: CN115068401A
Application number: CN202210761789.7A
Authority: CN
Inventors: 刘伟
Original assignee: Guangzhou Meisi Biotechnology Co ltd
Current assignee: Guangzhou Meisi Biotechnology Co ltd
Priority date: 2022-06-30
Filing date: 2022-06-30
Publication date: 2022-09-20

Abstract

The invention discloses long-acting oil-control plump and fluffy bionic amino acid shampoo and a preparation method thereof, and the long-acting oil-control plump and fluffy bionic amino acid shampoo comprises 40-50 parts of water, 2-10 parts of bionic amino acid, 1-3 parts of a pH regulator, 1-3 parts of decanediol, 1-5 parts of PCA zinc, 3-15 parts of a repairing agent, 5-15 parts of a plant extract, 2-10 parts of a soothing agent, 1-5 parts of a foaming agent, 1-3 parts of xylitol and 1-3 parts of essence. Has the advantages that: the royal jelly contains natural omega-hydroxy acid serving as an oil control component, and the royal jelly oil control factor simulates 10-hydroxydecanoic acid serving as the oil control component contained in the royal jelly through technical research and development, can control the generation of grease by reducing the number of active sebaceous glands and reducing sebum secretion, has excellent antibacterial activity, can strengthen the inhibition effect of the sebum secretion under the cooperation of PCA zinc, simultaneously maintains the moistening of the scalp, reduces the sensitivity and the activity of the sebaceous glands, achieves the state of water-oil balance, and has a more complete oil control mechanism.

Description

Long-acting oil-control plump and fluffy bionic amino acid shampoo and preparation method thereof

Technical Field

The invention relates to the technical field of shampoo production, and particularly relates to a long-acting oil-control plump and fluffy bionic amino acid shampoo and a preparation method thereof.

Background

The shampoo is a hair care product capable of cleaning hair, for example, an amino acid washing hair care shampoo with the publication number of CN 109602639B and the preparation method thereof comprise the following components in percentage by weight: 1% of PEG-60 amygdalin, 2% of PEG-7 glyceryl cocoate, 1% of PPG-3 octyl ether, 0.01-2% of glyceryl oleate, 0.01-2% of cocoyl glucoside, 1-30% of cocamidopropyl betaine, 1-30% of sodium lauroyl sarcosinate, 0.1-10% of decyl glucoside, 0.1-5% of PEG-80 sorbitan laurate, 1-15% of sodium methyl cocoyl taurate, 1-30% of sodium C14-16 olefin sulfonate, 0.1-5% of cocamidomethyl MEA, 0.1-5% of polyquaternium-6, 0.1-5% of polyquaternium-53, 0.01-0.5% of piroctone ethanolamine salt, 0.1-1% of phenoxyethanol, 0.1-0.5% of sodium benzoate, 0.01-1% of sodium citrate, 0.01-1% of citric acid, 0.01-1% of metal chelating agent, 0.01-1% of flavoring agent and the balance of deionized water, and meanwhile, the amino acid washing shampoo does not contain silicone oil, has good hair conditioning and hair nourishing effects, and can effectively solve the problem of dry and dry hair.

However, with the increase of the current social pressure, many people like staying up night, endocrine disorders are caused, immunity is reduced, nutrition of hair cannot be absorbed, and seborrheic alopecia is formed, the seborrheic alopecia is alopecia induced on the basis of excessive seborrhea, is often accompanied by increase of dandruff, greasy scalp and obvious pruritus, is mostly generated in young and strong years with vigorous sebaceous gland secretion, the hair is thin and soft, is accompanied by scalp seborrheic dermatitis, and gradually begins to lose hair from the top of the head, spreads and is greasy and bright red on the forehead, yellow and oily crusts are formed, and the seborrheic alopecia is a main cause of alopecia.

Therefore, the shampoo is urgently needed to solve the problem of seborrheic alopecia and enable the hair to be long-term, rich and fluffy.

An effective solution to the problems in the related art has not been proposed yet.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides the long-acting oil-control plump and fluffy bionic amino acid shampoo and the preparation method thereof, and the shampoo has the functions of purifying scalp by bionic amino acid components, inhibiting the activity of 5 alpha-reductase, efficiently controlling oil, resetting scalp microbial community, balancing scalp microecology and removing dandruff in a synergistic manner, thereby solving the problems in the prior art.

(II) technical scheme

In order to realize the functions of purifying the scalp by the bionic amino acid components, inhibiting the activity of 5 alpha-reductase, efficiently controlling oil, resetting the microbial community of the scalp, balancing the microecology of the scalp and cooperatively removing dandruff, the invention adopts the following specific technical scheme:

the invention is realized by the following steps:

according to another aspect of the invention, the long-acting oil-control plump and fluffy bionic amino acid shampoo is provided, and the shampoo comprises the following components in parts by weight:

the plant nutrient solution comprises 40-50 parts of water, 2-10 parts of bionic amino acid, 1-3 parts of a pH regulator, 1-3 parts of decanediol, 1-5 parts of PCA zinc, 3-15 parts of a repairing agent, 5-15 parts of a plant extract, 2-10 parts of a soothing agent, 1-5 parts of a foaming agent, 1-3 parts of xylitol and 1-3 parts of an essence.

Furthermore, the bionic amino acid comprises 1-5 parts of sarcosine and 1-5 parts of 10-hydroxydecanoic acid.

Further, the pH regulator comprises 1-3 parts of sebacic acid.

Further, the repairing agent comprises 1-5 parts of nicotinamide, 1-5 parts of biotin and 1-5 parts of zinc gluconate.

Further, the plant extract comprises 1-3 parts of yeast extract, 1-3 parts of aesculus hippocastanum seed extract, 1-3 parts of pomegranate bark extract, 1-3 parts of ammonium glycyrrhizinate and 1-3 parts of caffeine.

Further, the soothing agent comprises 1-5 parts of panthenol and 1-5 parts of beta-glucan.

Further, the foaming agent comprises 1-5 parts of sodium cocoyl isethionate.

Further, the essence comprises lavender oil and one or more of malthate and bergamot oil.

According to another aspect of the present invention, there is provided a method for preparing ammonium glycyrrhizinate, comprising the steps of:

s101, grinding 4-10 parts of glycyrrhizic acid crude product, adding 100mL of hydrochloric acid acidified 75-95% ethanol, wherein the pH value of the hydrochloric acid acidified ethanol is 3.5-4.0, extracting for 3-5h at the power of 150-300W by using an ultrasonic generator at the temperature of 40-50 ℃, and filtering the liquid.

S103: extracting the filtered filter residue with 50-150mL of ethanol under the same condition for 2-4h, combining the extracting solutions, dripping ammonia water while using an ultrasonic generator to keep the pH value of the solution between 7.2-7.5, and then standing in an environment at 15-25 ℃ for 0.3-0.7h to precipitate the solution.

S105, adding a proper amount of glacial acetic acid after precipitation, heating to 45-60 ℃, dispersing and blending into paste after 1-5 minutes, standing for 0.5-1.5 hours, and filtering.

S107: washing with a small amount of glacial acetic acid for 1-3 times after crystal separation, and decoloring and recrystallizing with 70-80% ethanol to obtain 1-3 parts of white crystals.

According to another aspect of the present invention, there is provided a preparation of an extract of pomegranate rind, comprising the steps of:

s201, removing impurities from immature pomegranate rind, crushing and crushing to obtain 3-10 parts of crude pomegranate rind.

S203, the treated crude pomegranate bark product is put into 65-75% ethanol for crude extraction for 2-5 times, and then is put into an ultrasonic generator with the power of 250-300W for extraction for 2-4h, and is heated to 40-60 ℃.

S205, adding acid liquor to adjust the pH value of the solution to 2-6, and adsorbing by using a macroporous resin chromatographic column, wherein the macroporous resin is one of D-101, D-201 and HP-20 type macroporous resins.

S207, washing the chromatographic column by using deionized water, eluting the chromatographic column by using an eluent with the ethanol concentration of 20-40 percent, and finally carrying the colloidal extract.

According to another aspect of the invention, a preparation method of a long-acting oil-control plump and fluffy bionic amino acid shampoo is provided, and comprises the following steps:

s301: heating 20-25 parts of water to 50-70 ℃, then grinding 1-3 parts of yeast extract, 1-3 parts of aesculus hippocastanum seed extract, 1-3 parts of pomegranate bark extract, 1-3 parts of ammonium glycyrrhizinate and 1-3 parts of caffeine, mixing with water, and stirring for 4-6 hours to obtain solution A.

S303: then adding 1-5 parts of nicotinamide, 1-5 parts of biotin, 1-5 parts of zinc gluconate and 1-5 parts of xylitol into the solution A, and simultaneously mixing for 1.5-2h in an ultrasonic generator at the power of 200-.

S305, heating 20-25 parts of water to 40-65 ℃, adding 1-3 parts of decanediol, 1-5 parts of PCA zinc, 1-5 parts of panthenol and 1-5 parts of beta-glucan into the water, stirring and mixing for 2-3 hours to obtain a solution B.

S307, simultaneously adding the solution A and the solution B into a stirring device, stirring at the temperature of 55-60 ℃, simultaneously adding 1-5 parts of sodium cocoyl isethionate in the stirring process, then adding 1-3 parts of sebacic acid, adjusting the pH value of the solution to 7.5-8.0, and stirring to obtain the shampoo.

The raw material components adopted by the invention are explained as follows:

sarcosine: when used in shampoo products, it is useful for preventing hair damage and promoting the self-repair of damaged hair to enhance the luster and elasticity of hair, and is prepared from bark of Quillaja saponaria Molina by extracting with hot water or aqueous ethanol, precipitating with diethyl ether or acetone, recrystallizing, and refining.

10-hydroxydecanoic acid: through technical research and development, the oil control component 10-hydroxydecanoic acid contained in the royal jelly is simulated, the generation of grease can be controlled by reducing the number of active sebaceous glands and reducing sebum secretion, and meanwhile, the royal jelly has excellent antibacterial activity.

Sebacic acid: is a pH adjusting agent and is obtained by purchasing.

Decanediol: reducing water activity, inhibiting microbial growth, and obtaining by purchasing.

Zinc PCA: the process of sebum secretion from sebaceous glands is called seborrhea, the zinc PCA can control the secretion of grease, meanwhile, the zinc PCA is zinc pyrrolidone carboxylate, and the shampoo containing the zinc PCA has the function of removing dandruff and is obtained by purchasing.

Nicotinamide: the nicotinamide can promote the circulation of the cuticle and accelerate the metabolism of epidermal cells, has a certain antioxidation effect, and can promote the blood circulation and enhance the nutrition supply of hair so as to achieve the effects of strengthening hair roots and reducing hair loss, and is obtained by purchasing.

Biotin: biotin belongs to vitamin B group, can maintain organism nutrition, prevent dermatosis, promote lipid metabolism and other physiological functions, and is obtained by purchasing.

Zinc gluconate: helps to treat dandruff and thereby improve hair health, and is available commercially.

Yeast extract (B): the yeast extract is a product obtained by completely autolyzing yeast by using a self-hydrolytic enzyme system after plasmolysis, and removing cell walls and insoluble molecules. The hydrolysis degree of the yeast protein is strictly controlled in the production process to meet different application requirements; finally, the yeast extract is concentrated into a semi-paste and paste product, the oil-embedded, microcapsule and microparticle powdered product is suitable for different application requirements, the yeast extract and panthenol are applied to the scalp environment to remove excessive oil of the scalp, the water-oil balance of the scalp is maintained, the hair follicle is in a healthier environment, can breathe freely, and the hair follicle is obtained by extraction.

Horse chestnut seed extract: is rich in saponin compounds, has effects of removing oil and fat, mildness, bioactivity, good permeability, and anti-dermatitis, can be combined with strong eliminating effect on superoxide radical, can relieve skin allergy, can prevent and treat skin erythema, edema, inflammation and allergy, can enhance skin metabolism, and has anti-aging effect.

Pomegranate rind extract: the immature pomegranate peel has high and rich polyphenol content, has the functions of reducing oil secretion, improving skin hyperkeratosis, inhibiting inflammation, inhibiting harmful bacteria, inhibiting generation of a biological membrane and the like, and is obtained by extraction.

Ammonium glycyrrhizinate: extracted from liquorice, has high sweetness and foamability, is safe and nontoxic, has the functions of resisting inflammation, resisting oxidation and inhibiting bacteria, effectively removing superoxide ions and hydroxyl free radicals and obviously inhibiting liposome peroxide, can be used for sun protection, whitening, conditioning, relieving itching, growing hair, protecting hair and the like, and is obtained by purchasing.

Caffeine: the main causes of AGA are dihydrotestosterone, testosterone is said to be the first follicular killer, caffeine is present to counter the damage of DHT to the hair papilla, and has some hair growth promoting effects, hair loss occurs most easily in the forehead and the top of the head, these areas are poorly resistant to DHT, the follicular killer, and caffeine ameliorates this problem and is purchased.

Panthenol: the panthenol can be covered on the surface of hair to protect the hair and deeply permeate into the hair, and the hair care effect is a lasting moisturizing function, so that the hair is prevented from being split and damaged, the density of the hair is increased, and the luster of the hair is improved.

Beta-glucan: polysaccharides consisting of glucose units, most of which are bound via beta-1, 3, have an effective soothing and moisturizing effect on hair in shampoos.

Xylitol: can inhibit the expression of various genes related to synthesis, thereby preventing the generation of biological membranes.

Sodium cocoyl isethionate: the natural vegetable oil is derived, can be completely degraded, has better environmental protection property, can provide rich and fine foam, and has excellent degreasing capability.

(III) advantageous effects

Compared with the prior art, the invention provides the long-acting oil-control plump and fluffy bionic amino acid shampoo and the preparation method thereof, and the preparation method has the following beneficial effects:

(1) the royal jelly contains natural oil-control component omega-hydroxy acid, and the royal jelly oil-control factor simulates oil-control component 10-hydroxydecanoic acid contained in the royal jelly through technical research and development, can control the generation of grease by reducing the number of active sebaceous glands and reducing sebum secretion, has excellent antibacterial activity, can strengthen the inhibition effect of sebum secretion under the cooperation of PCA zinc, simultaneously maintains the moistening of scalp, reduces the sensitivity and the activity of the sebaceous glands, achieves the state of water-oil balance, and has a more perfect oil-control mechanism.

(2) The added pomegranate bark extract has the functions of reducing oil secretion, improving skin hyperkeratosis, inhibiting inflammation, inhibiting harmful bacteria, inhibiting the generation of a biological membrane and the like, and the expression of various synthesis related genes is inhibited by matching xylitol, so that the generation of the biological membrane is prevented, and the generation of dandruff is reduced.

(3) The invention can repair cuticle, promote the circulation of the cuticle and accelerate the metabolism of epidermal cells by adding the nicotinamide, the biotin and the zinc gluconate, has certain antioxidation, and enhances the nutrition supply of hair by promoting blood circulation, thereby achieving the effects of strengthening hair roots, reducing hair loss, maintaining the nutrition of organisms, preventing skin diseases, promoting lipid metabolism and other physiological functions.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

FIG. 1 is a flow chart of preparation of ammonium glycyrrhetate for a long-acting oil-control plump and fluffy bionic amino acid shampoo and a preparation method thereof according to an embodiment of the invention;

fig. 2 is a flow chart of preparation of pomegranate bark extract for the long-acting oil-control plump and fluffy bionic amino acid shampoo and the preparation method thereof according to the embodiment of the invention;

fig. 3 is a flow chart for preparing a long-acting oil-control plumping and fluffy bionic amino acid shampoo and a preparation method thereof according to an embodiment of the invention;

FIG. 4 is a statistical table of maximum value of scalp oil detection data of volunteers of the long-acting oil-control plump and fluffy bionic amino acid shampoo and the preparation method thereof according to the embodiment of the invention;

fig. 5 is a statistical table of minimum value of scalp oil detection data of volunteers of the long-acting oil-control plump and fluffy bionic amino acid shampoo and the preparation method thereof according to the embodiment of the invention.

Detailed Description

For further explanation of the various embodiments, the drawings which form a part of the disclosure and which are incorporated in and constitute a part of this specification, illustrate embodiments and, together with the description, serve to explain the principles of operation of the embodiments, and to enable others of ordinary skill in the art to understand the various embodiments and advantages of the invention, and, by reference to these figures, reference is made to the accompanying drawings, which are not to scale and wherein like reference numerals generally refer to like elements.

According to another aspect of the invention, a long-acting oil-control plump and fluffy bionic amino acid shampoo is provided,

the long-acting oil-control plump and fluffy bionic amino acid shampoo comprises the following components in parts by weight:

Wherein, the bionic amino acid comprises 1-5 parts of sarcosine and 1-5 parts of 10-hydroxydecanoic acid.

Wherein the pH regulator comprises 1-3 parts of sebacic acid.

Wherein, the repairing agent comprises 1-5 parts of nicotinamide, 1-5 parts of biotin and 1-5 parts of zinc gluconate.

Wherein the plant extract comprises 1-3 parts of yeast extract, 1-3 parts of aesculus hippocastanum seed extract, 1-3 parts of pomegranate bark extract, 1-3 parts of ammonium glycyrrhizinate and 1-3 parts of caffeine.

Wherein, the soothing agent comprises 1-5 parts of panthenol and 1-5 parts of beta-glucan.

Wherein the foaming agent comprises 1-5 parts of cocoyl isethionate sodium.

Wherein the essence comprises lavender oil and one or more of malthate and bergamot oil.

In order to clearly understand the technical scheme of the invention, the technical scheme of the invention is described in detail through specific examples.

The first embodiment is as follows:

40 parts of water, 2 parts of bionic amino acid, 1 part of pH regulator, 1 part of decanediol, 1 part of PCA zinc, 3 parts of repairing agent, 5 parts of plant extract, 2 parts of soothing agent, 1 part of foaming agent, 1 part of xylitol and 1 part of essence.

Wherein, the bionic amino acid comprises 1 part of sarcosine and 1 part of 10-hydroxydecanoic acid.

Wherein the pH regulator comprises 1 part of sebacic acid.

Wherein, the repairing agent comprises 1 part of nicotinamide, 1 part of biotin and 1 part of zinc gluconate.

Wherein the plant extract comprises 1 part of yeast extract, 1 part of aesculus hippocastanum seed extract, 1 part of pomegranate bark extract, 1 part of ammonium glycyrrhizinate and 1 part of caffeine.

Wherein, the soothing agent comprises 1 part of panthenol and 1 part of beta-glucan.

Wherein the foaming agent comprises 1 part of cocoyl isethionate sodium.

Wherein the essence is lavender oil.

The preparation method of ammonium glycyrrhizinate comprises the following steps:

s101, grinding 4 parts of glycyrrhizic acid crude product, adding 100mL of 755% ethanol acidified by hydrochloric acid, wherein the pH value of the ethanol acidified by hydrochloric acid is 3.5, simultaneously extracting for 3h at the power of 150W by using an ultrasonic generator in the environment of 40 ℃, and then filtering the liquid.

S103: extracting the filtered residue with 50mL of ethanol under the same conditions for 2h, mixing the extractive solutions, adding ammonia water dropwise while ultrasonic wave generator to maintain pH of the solution at 7.2, and standing at 15 deg.C for 0.3h to precipitate the solution.

And S105, adding a proper amount of glacial acetic acid after precipitation, heating to 45 ℃, dispersing and blending the mixture into paste after 1 minute, standing for 0.5 hour, and filtering.

S107: washing the crystal with a small amount of glacial acetic acid for 1-3 times after crystal separation, and decoloring and recrystallizing with 70% ethanol to obtain 1 part of white crystal.

The preparation method of the pomegranate rind extract comprises the following steps:

s201, removing impurities from immature pomegranate rind, crushing and crushing to obtain 3 parts of crude pomegranate rind.

S203, the processed crude pomegranate peel is put into 65% ethanol for 2 times of crude extraction, and then the crude pomegranate peel is put into an ultrasonic generator with the power of 250W for extraction for 2 hours and is heated to 40 ℃.

S205, adding acid liquor to adjust the pH value of the solution to 2, and adsorbing the solution by using a macroporous resin chromatographic column, wherein the macroporous resin is one of D-101, D-201 and HP-20 type macroporous resins.

And S207, washing the chromatographic column by using deionized water, eluting the chromatographic column by using an eluent with the ethanol concentration of 20 percent, and finally bringing the colloidal extract.

The preparation method of the long-acting oil-control plump and fluffy bionic amino acid shampoo comprises the following steps:

s301: heating 20 parts of water to 50 ℃, and then grinding 1 part of yeast extract, 1 part of aesculus hippocastanum seed extract, 1 part of pomegranate rind extract, 1 part of ammonium glycyrrhizinate and 1 part of caffeine, mixing with water and stirring for 4 hours to obtain a solution A.

S303: then 1 part of nicotinamide, 1 part of biotin, 1 part of zinc gluconate and 1 part of xylitol are added into the solution A, and are mixed for 1.5 hours in an ultrasonic generator at the power of 200W.

S305, heating 20 parts of water to 40 ℃, and adding 1 part of decanediol, 1 part of PCA zinc, 1 part of panthenol and 1 part of beta-glucan into the water to stir and mix for 2 hours to obtain a solution B.

And S307, simultaneously adding the solution A and the solution B into a stirring device, stirring at the temperature of 55 ℃, simultaneously adding 1 part of cocoyl isethionate sodium in the stirring process, adding 1 part of sebacic acid, regulating the pH value of the solution to 7.5, and stirring to obtain the shampoo.

Example two:

45 parts of water, 6 parts of bionic amino acid, 2 parts of pH regulator, 2 parts of decanediol, 3 parts of PCA zinc, 9 parts of repairing agent, 10 parts of plant extract, 6 parts of soothing agent, 3 parts of foaming agent, 2 parts of xylitol and 2 parts of essence.

Wherein, the bionic amino acid comprises 3 parts of sarcosine and 3 parts of 10-hydroxydecanoic acid.

Wherein the pH regulator comprises 2 parts of sebacic acid.

Wherein, the repairing agent comprises 3 parts of nicotinamide, 3 parts of biotin and 3 parts of zinc gluconate.

Wherein the plant extract comprises 2 parts of yeast extract, 2 parts of aesculus hippocastanum seed extract, 2 parts of pomegranate bark extract, 2 parts of ammonium glycyrrhizinate and 2 parts of caffeine.

Wherein, the soothing agent comprises 3 parts of panthenol and 3 parts of beta-glucan.

Wherein the foaming agent comprises 3 parts of cocoyl isethionate sodium.

Wherein the essence comprises malthate.

s101, grinding 7 parts of glycyrrhizic acid crude product, adding 135mL of hydrochloric acid acidified 85% ethanol, wherein the pH value of the hydrochloric acid acidified ethanol is 3.7, simultaneously extracting for 4 hours at the power of 225W by using an ultrasonic generator in the environment of 45 ℃, and then filtering the liquid.

S103: extracting the filtered residue with 100mL of ethanol under the same conditions for 3h, mixing the extractive solutions, adding ammonia water dropwise while ultrasonic wave generator to maintain pH of the solution at 7.3, and standing at 20 deg.C for 0.5h to precipitate the solution.

And S105, adding a proper amount of glacial acetic acid after precipitation, heating to 57 ℃, dispersing and blending into paste after 3 minutes, standing for 1 hour, and filtering.

S107: washing with small amount of glacial acetic acid for 2 times after crystal separation, and decolorizing and recrystallizing with 75% ethanol to obtain 2 parts of white crystal.

s201, removing impurities from immature pomegranate rind, crushing and crushing to obtain 6 parts of crude pomegranate rind.

S203, the processed crude pomegranate rind product is put into 70% ethanol for 3 times of crude extraction, and then is put into an ultrasonic generator with 275W power for extraction for 3 hours, and is heated to 50 ℃.

S205, adding acid liquor to adjust the pH value of the solution to 4, and adsorbing the solution by using a macroporous resin chromatographic column, wherein the macroporous resin is one of D-101, D-201 and HP-20 type macroporous resins.

And S207, washing the chromatographic column by using deionized water, eluting the chromatographic column by using an eluent with the ethanol concentration of 30 percent, and finally bringing the colloidal extract.

s301: heating 20-25 parts of water to 60 ℃, and then grinding 2 parts of yeast extract, 2 parts of aesculus hippocastanum seed extract, 2 parts of pomegranate rind extract, 2 parts of ammonium glycyrrhizinate and 2 parts of caffeine, mixing with water, and stirring for 5 hours to obtain a solution A.

S303: then adding 3 parts of nicotinamide, 3 parts of biotin, 3 parts of zinc gluconate and 3 parts of xylitol into the solution A, and simultaneously mixing for 1.75h in an ultrasonic generator at the power of 200-300W.

S305, heating 20-25 parts of water to 55 ℃, adding 2 parts of decanediol, 3 parts of PCA zinc, 3 parts of panthenol and 3 parts of beta-glucan into the water, and stirring and mixing for 2.5 hours to obtain a solution B.

And S307, simultaneously adding the solution A and the solution B into a stirring device, stirring at the temperature of 57 ℃, simultaneously adding 3 parts of cocoyl isethionate sodium in the stirring process, adding 2 parts of sebacic acid, adjusting the pH of the solution to 7.7, and stirring to obtain the shampoo.

Example three:

50 parts of water, 10 parts of bionic amino acid, 3 parts of pH regulator, 3 parts of decanediol, 5 parts of PCA zinc, 15 parts of repairing agent, 15 parts of plant extract, 10 parts of soothing agent, 5 parts of foaming agent, 3 parts of xylitol and 3 parts of essence.

Wherein, the bionic amino acid comprises 5 parts of sarcosine and 5 parts of 1 hydroxydecanoic acid.

Wherein the pH regulator comprises 3 parts of sebacic acid.

Wherein, the repairing agent comprises 5 parts of nicotinamide, 5 parts of biotin and 5 parts of zinc gluconate.

Wherein the plant extract comprises 3 parts of yeast extract, 3 parts of aesculus hippocastanum seed extract, 3 parts of pomegranate bark extract, 3 parts of ammonium glycyrrhizinate and 3 parts of caffeine.

Wherein, the soothing agent comprises 5 parts of panthenol and 5 parts of beta-glucan.

Wherein the foaming agent comprises 5 parts of cocoyl isethionate sodium.

Wherein the essence comprises bergamot oil.

s101, grinding 10 parts of glycyrrhizic acid crude product, adding 170mL of 795% ethanol acidified by hydrochloric acid, wherein the pH value of the ethanol acidified by hydrochloric acid is 4.0, extracting for 5 hours at the power of 300W by using an ultrasonic generator in an environment of 50 ℃, and filtering the liquid.

S103: extracting the filtered residue with 150mL ethanol under the same conditions for 4h, mixing extractive solutions, adding ammonia water dropwise while ultrasonic wave generator to maintain pH of the solution at 7.5, and standing at 125 deg.C for 0.7h to precipitate the solution.

And S105, adding a proper amount of glacial acetic acid after precipitation, heating to 60 ℃, dispersing and blending the mixture into paste after 5 minutes, standing for 1.5 hours, and filtering.

S107: washing with small amount of glacial acetic acid for 3 times after crystal separation, and decolorizing and recrystallizing with 80% ethanol to obtain 3 parts of white crystal.

s201, removing impurities from immature pomegranate rind, crushing and crushing to obtain 10 parts of crude pomegranate rind.

S203, the processed crude pomegranate peel is put into 75% ethanol for 5 times of crude extraction, and then the crude pomegranate peel is put into an ultrasonic generator with the power of 300W for extraction for 4 hours and is heated to 60 ℃.

S205, adding acid liquor to adjust the pH value of the solution to 6, and adsorbing the solution by using a macroporous resin chromatographic column, wherein the macroporous resin is one of D-101, D-201 and HP-20 type macroporous resins.

And S207, washing the chromatographic column by using deionized water, eluting the chromatographic column by using an eluent with the ethanol concentration of 40 percent, and finally bringing the colloidal extract.

s301: heating 25 parts of water to 70 ℃, and then grinding 3 parts of yeast extract, 3 parts of aesculus hippocastanum seed extract, 3 parts of pomegranate rind extract, 3 parts of ammonium glycyrrhizinate and 3 parts of caffeine, mixing with water and stirring for 6 hours to obtain a solution A.

S303: then 5 parts of nicotinamide, 5 parts of biotin, 5 parts of zinc gluconate and 5 parts of xylitol are added into the solution A, and are mixed for 2 hours in an ultrasonic generator at the power of 300W.

And S305, heating 225 parts of water to 465 ℃, adding 3 parts of decanediol, 5 parts of PCA zinc, 5 parts of panthenol and 5 parts of beta-glucan into the water, and stirring and mixing for 3 hours to obtain a solution B.

And S307, simultaneously adding the solution A and the solution B into a stirring device, stirring at the temperature of 60 ℃, simultaneously adding 5 parts of cocoyl isethionate sodium in the stirring process, adding 3 parts of sebacic acid, regulating the pH value of the solution to 8.0, and stirring to obtain the shampoo.

Comparative example one:

comparative example one differs from example one in that comparative example one does not contain the yeast extract, and the other is the same.

Comparative example two:

comparative example two differs from example one in that comparative example two does not contain the aesculus hippocastanum seed extract, and the rest are the same.

Comparative example three:

the third comparative example is different from the first example in that the third comparative example does not contain the pomegranate rind extract, and the rest is the same.

Comparative example four:

comparative example four differs from example one in that comparative example four does not contain the ammonium glycyrrhizinate, and the rest is the same.

Comparative example five:

comparative example five differs from example one in that comparative example five does not contain the caffeine, and the other is the same.

In practical application, by means of the technical scheme, the long-acting oil-control plump bionic amino acid shampoo can be invented, scalp is purified through bionic amino acid components, 5 alpha-reductase activity is inhibited, oil is efficiently controlled, scalp microbial community is reset, scalp microecological balance is achieved, cooperative dandruff removal is achieved, natural oil-control component omega-hydroxy acid is contained in royal jelly, royal jelly oil-control factor is 10-hydroxydecanoic acid contained in royal jelly through technical research and development, oil-control component 10-hydroxydecanoic acid can be reduced, oil production can be controlled through reduction of active sebaceous gland number and reduction of sebum secretion, meanwhile, excellent antibacterial activity is achieved, inhibition effect of sebum secretion can be enhanced under cooperation of PCA zinc, scalp moistening is maintained, sensitivity and activity of sebaceous glands are reduced, a water-oil balance state is achieved, and a more complete oil-control mechanism is achieved, meanwhile, the pomegranate bark extract has the functions of reducing oil secretion, improving the hyperkeratosis of the scalp, inhibiting inflammation, inhibiting harmful bacteria, inhibiting the generation of a biological membrane and the like, and the expression of various synthesis related genes is inhibited by matching with xylitol, so that the generation of the biological membrane is prevented, the generation of dandruff is reduced, and the nicotinamide and the biotin can repair the cuticle, promote the circulation of the cuticle and accelerate the metabolism of epidermal cells, and simultaneously have a certain antioxidation effect, and the effects of strengthening hair roots, reducing hair loss, maintaining the nutrition of an organism, preventing skin diseases, promoting the physiological functions of lipid metabolism and the like are achieved.

By means of the technical scheme, the following method is adopted to carry out experiments on the materials, and the specific steps are as follows:

s401, selecting 7 male volunteers 20-40 years old as A, B, C, D, E, F, G male volunteers and A, B, C, D, E, F, G male seborrheic alopecia patients with the same degree because male grease secretion is vigorous;

s403, aiming at the shampoo which is used by the volunteer A and does not contain bionic amino acid and plant extracts and is purchased on the market, the volunteer B uses the long-acting oil-controlling plump and fluffy bionic amino acid shampoo, and the shampoos with the comparative examples of one, two, three, four and five are respectively used by the volunteer C, the volunteer D, the volunteer E, the volunteer F and the volunteer G;

s405, comparing the sebum content of the shampoo used by a volunteer A, B, C, D, E, F, G for 30 days, and finding that the data of the top of the head are most stable and representative in the detection of different parts of the head by adopting a SEBUMEETERSM 810 skin oil tester of the German COARAGE + KHAZAKA company, so that the data of the top of the head are used as the reference data of the experiment;

s407, because the human bodies in different time periods secrete different grease, in order to enable data monitoring to be uniform, all volunteers start to use appointed shampoo at eight o 'clock in the afternoon every day, grease detection of the scalp is carried out at eight o' clock in the morning on the next day, and data are obtained by detecting the amount of sebum on the top surface of the head of the volunteer in different time periods;

s409, the data are sorted, and the data of the 11 th day, the 21 st day and the 31 st day eight morning are used for preparing a table, wherein the number +12h is 12 hours after the hair is washed for the corresponding using days, for example: 10+12h, namely the tenth day of continuous use of the shampoo, and the twelfth hour after the shampoo on the same day.

Through comparison, the quantity of the scalp sebum of the head of the volunteer B is obviously reduced after the scalp is continuously used for a certain number of days, the hair-care shampoo has a good oil control effect, can keep the dry and comfortable effect of the head for a long time, prevents the sebum from being generated too fast, keeps the hair fluffy, has the same obvious control effect on the quantity of the scalp sebum of the hair shampoos containing the amino acid analogues used by the volunteer C, the volunteer D, the volunteer E, the volunteer F and the volunteer G, controls the sebum generation by controlling the activity of the 5 alpha-reductase activity, reducing the number of active sebaceous glands and reducing the sebum secretion to control the grease generation, and further solves the problem of the seborrheic alopecia from a root source.

In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "disposed," "connected," "secured," "screwed" and the like are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate, and may be communication between two elements or interaction relationship between two elements, unless otherwise specifically limited, and the specific meaning of the terms in the present invention will be understood by those skilled in the art according to specific situations.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. The long-acting oil-control plump and fluffy bionic amino acid shampoo is characterized by comprising 40-50 parts of water, 2-10 parts of bionic amino acid, 1-3 parts of pH regulator, 1-3 parts of decanediol, 1-5 parts of PCA zinc, 3-15 parts of repairing agent, 5-15 parts of plant extract, 2-10 parts of soothing agent, 1-5 parts of foaming agent, 1-3 parts of xylitol and 1-3 parts of essence;

2. The long-acting oil-control voluminous biomimetic amino acid shampoo as claimed in claim 1, wherein the pH regulator comprises 1-3 parts of sebacic acid.

3. The long-acting oil-control plumping and fluffy bionic amino acid shampoo as claimed in claim 2, wherein the repairing agent comprises 1-5 parts of nicotinamide, 1-5 parts of biotin and 1-5 parts of zinc gluconate.

4. The long-acting oil-control voluminous bionic amino acid shampoo as claimed in claim 3, wherein the plant extract comprises 1-3 parts of yeast extract, 1-3 parts of aesculus hippocastanum seed extract, 1-3 parts of pomegranate peel extract, 1-3 parts of ammonium glycyrrhizinate and 1-3 parts of caffeine.

5. The long-acting oil-control voluminous bionic amino acid shampoo as claimed in claim 4, wherein the soothing agent comprises 1-5 parts of panthenol and 1-5 parts of beta-glucan.

6. The long-acting oil-control plump and fluffy bionic amino acid shampoo as claimed in claim 5, wherein the foaming agent comprises 1-5 parts of cocoyl isethionate sodium.

7. The long-acting oil-control plump and fluffy bionic amino acid shampoo as claimed in claim 6, wherein the essence comprises lavender oil and one or more of malthate and bergamot oil.

8. The long-acting oil-control plump and fluffy bionic amino acid shampoo as claimed in claim 4, wherein the preparation of the ammonium glycyrrhetate comprises the following steps:

s101, grinding 4-10 parts of glycyrrhizic acid crude product, adding 100-170mL of 75-95% ethanol acidified by hydrochloric acid, wherein the pH value of the ethanol acidified by hydrochloric acid is 3.5-4.0, extracting for 3-5h at the power of 150-300W by using an ultrasonic generator at the temperature of 40-50 ℃, and filtering the liquid;

s103: extracting the filtered filter residue with 50-150mL of ethanol under the same condition for 2-4h, combining the extracting solutions, dripping ammonia water in an ultrasonic generator to keep the pH value of the solution between 7.2-7.5, and then standing in an environment at 15-25 ℃ for 0.3-0.7h to precipitate the solution;

s105, adding a proper amount of glacial acetic acid after precipitation, heating to 45-60 ℃, dispersing and blending into paste after 1-5 minutes, standing for 0.5-1.5 hours, and filtering;

s107: washing the crystal with a small amount of glacial acetic acid for 1-3 times after crystal separation, and decoloring and recrystallizing with 70-80% ethanol to obtain 1-3 parts of white crystals.

9. The long-acting oil-control plump and fluffy bionic amino acid shampoo as claimed in claim 4, wherein the preparation of the pomegranate bark extract comprises the following steps:

s201, removing impurities from immature pomegranate rind, crushing and crushing to obtain 3-10 parts of crude pomegranate rind;

s203, placing the treated crude pomegranate peel product into 65-75% ethanol for crude extraction for 2-5 times, then placing the crude pomegranate peel product into an ultrasonic generator with the power of 250-300W for extraction for 2-4h, and simultaneously heating the crude pomegranate peel product to 40-60 ℃;

s205, adding acid liquor to adjust the pH value of the solution to 2-6, and adsorbing the solution by using a macroporous resin chromatographic column, wherein the macroporous resin is one of D-101, D-201 and HP-20 type macroporous resins;

s207, washing the chromatographic column by using deionized water, eluting the chromatographic column by using an eluent with the ethanol concentration of 20-40 percent, and finally bringing the colloidal extract.

10. The preparation method of the long-acting oil-control plump and fluffy bionic amino acid shampoo, which is used for preparing the long-acting oil-control plump and fluffy bionic amino acid shampoo according to claim 7, comprises the following steps:

s301: heating 20-25 parts of water to 50-70 ℃, then grinding 1-3 parts of yeast extract, 1-3 parts of aesculus hippocastanum seed extract, 1-3 parts of pomegranate bark extract, 1-3 parts of ammonium glycyrrhizinate and 1-3 parts of caffeine, mixing with water, and stirring for 4-6 hours to obtain a solution A;

s303: then adding 1-5 parts of nicotinamide, 1-5 parts of biotin, 1-5 parts of zinc gluconate and 1-5 parts of xylitol into the solution A, and simultaneously mixing for 1.5-2h in an ultrasonic generator at the power of 200-;

s305, heating 20-25 parts of water to 40-65 ℃, adding 1-3 parts of decanediol, 1-5 parts of PCA zinc, 1-5 parts of panthenol and 1-5 parts of beta-glucan into the water, stirring and mixing for 2-3 hours to obtain a solution B;