CN115057865A - 一种磷酸可待因半水合物的制备方法 - Google Patents
一种磷酸可待因半水合物的制备方法 Download PDFInfo
- Publication number
- CN115057865A CN115057865A CN202210505813.0A CN202210505813A CN115057865A CN 115057865 A CN115057865 A CN 115057865A CN 202210505813 A CN202210505813 A CN 202210505813A CN 115057865 A CN115057865 A CN 115057865A
- Authority
- CN
- China
- Prior art keywords
- codeine
- preparation
- codeine phosphate
- hemihydrate
- phosphate hemihydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210505813.0A CN115057865B (zh) | 2022-05-10 | 2022-05-10 | 一种磷酸可待因半水合物的制备方法 |
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CN202210505813.0A CN115057865B (zh) | 2022-05-10 | 2022-05-10 | 一种磷酸可待因半水合物的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN115057865A true CN115057865A (zh) | 2022-09-16 |
CN115057865B CN115057865B (zh) | 2023-03-31 |
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CN202210505813.0A Active CN115057865B (zh) | 2022-05-10 | 2022-05-10 | 一种磷酸可待因半水合物的制备方法 |
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CN (1) | CN115057865B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090304584A1 (en) * | 2006-07-17 | 2009-12-10 | Ramot At Tel Aviv University Ltd. | Conjugates comprising a gaba- or glycine compound, pharmaceutical compositions and combinations thereof and their use in treating cns disorders |
DE102015012195A1 (de) * | 2015-09-23 | 2017-03-23 | Rougé Lüloff | Codein zur Verwendung bei der Behandlung von Allergien |
GB201910294D0 (en) * | 2018-07-20 | 2019-09-04 | Wockhardt Uk Ltd | Liquid pharmaceutical composition for oral administration comprising paracetamol and codeine phosphate |
-
2022
- 2022-05-10 CN CN202210505813.0A patent/CN115057865B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090304584A1 (en) * | 2006-07-17 | 2009-12-10 | Ramot At Tel Aviv University Ltd. | Conjugates comprising a gaba- or glycine compound, pharmaceutical compositions and combinations thereof and their use in treating cns disorders |
DE102015012195A1 (de) * | 2015-09-23 | 2017-03-23 | Rougé Lüloff | Codein zur Verwendung bei der Behandlung von Allergien |
GB201910294D0 (en) * | 2018-07-20 | 2019-09-04 | Wockhardt Uk Ltd | Liquid pharmaceutical composition for oral administration comprising paracetamol and codeine phosphate |
Non-Patent Citations (5)
Title |
---|
LANGES, CHRISTOPH等: "Codeine dihydrogen phosphate hemihydrate", 《ACTA CRYSTALLOGRAPHICA, SECTION C: CRYSTAL STRUCTURE COMMUNICATIONS》 * |
PETRUSEVSKI, GJORGJI等: "Solid-state transformation of the pseudopolymorphic forms of codeine phosphate hemihydrate and codeine phosphate sesquihydrate monitored by vibrational spectroscopy and thermal analysis", 《JOURNAL OF MOLECULAR STRUCTURE》 * |
PETRUSEVSKI, GJORGJI等: "Solvatomorphism of codeine phosphate sesquihydrate-Vibrational spectroscopy and thermoanalytical characterization", 《VIBRATIONAL SPECTROSCOPY》 * |
RUNCEVSKI, TOMCE等: "On the hydrates of codeine phosphate: the remarkable influence of hydrogen bonding on the crystal size", 《CHEMICAL COMMUNICATIONS (CAMBRIDGE, UNITED KINGDOM) 》 * |
王雪等: "磷酸可待因平衡溶解度及油水分配系数的测定", 《药物分析杂志》 * |
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Publication number | Publication date |
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CN115057865B (zh) | 2023-03-31 |
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Inventor after: Zhao Yuefeng Inventor after: Si Langyun Inventor after: Cai Lai Inventor after: Guo Yingshan Inventor after: Li Liping Inventor after: Wang Qian Inventor after: Li Xiaopeng Inventor after: Miao Qingzhu Inventor after: Li Yuanyuan Inventor after: Zhu Jingya Inventor after: Liu Tongbin Inventor before: Zhao Yuefeng Inventor before: Si Langyun Inventor before: Cai Lai Inventor before: Guo Yingshan Inventor before: Li Liping Inventor before: Wang Qian Inventor before: Li Xiaopeng Inventor before: Miao Qingzhu Inventor before: Li Yuanyuan Inventor before: Zhu Jingya Inventor before: Liu Tongbin |