CN115040604B - 一种心神安胶囊的中药组合物及其制备方法 - Google Patents
一种心神安胶囊的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种心神安胶囊的中药组合物及其制备方法，包括：绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡。本发明所述的一种心神安胶囊的中药组合物及其制备方法，通过诸药配合，气旺血充，心脾得以补益，则诸证自愈，方中的绞股蓝、石菖蒲和缬草能增强益气、宁心安神，五味子和麦冬，能养阴生津，丹参、川芎、延胡索和柴胡能起到活血、疏肝祛瘀的功效，远志，能起到安神益智、交通心肾的功效，人参，能起到生津养血的功效，诸药配合增强了健脾益气，养血安神的功效，在治疗心脾两虚证时能起到到良好的效果。
Description
技术领域
本发明涉及心神安胶囊的中药组合物领域，特别涉及一种心神安胶囊的中药组合物及其制备方法。
背景技术
心神安胶囊是治疗心脾两虚证的产品，具有健脾益气，养心安神的功能。症见倦怠乏力，神疲健忘，心慌，失眠多梦。
心脾两虚证，中医病证名，是指心血不足，脾气虚弱所表现的证候，其病机是脾为气血生化之源，又具统血功能，脾气虚弱，生血不足，或统摄无力，血溢脉外，均可导致心血亏虚，心主血，血充则气足，血虚则气弱，心血不足，无以化气，则脾气亦虚，心血不足，心失所养，则心悸怔忡；心神不宁，故失眠多梦，头目失养，则眩晕健忘；肌肤失荣，故面色萎黄无华，脾气不足，运化失健，故食欲不振，腹胀便溏；气虚机能活动减退，故神倦乏力，脾虚不能摄血，可见皮下出血，妇女经量减少，色淡质稀，淋漓不尽，舌质淡嫩，脉细弱，皆为气血不足之征。
发明内容
本发明的主要目的在于提供一种心神安胶囊的中药组合物及其制备方法，可以有效解决背景技术中的问题。
为实现上述目的，本发明采取的技术方案为：
一种心神安胶囊的中药组合物，包括：绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡，所述绞股蓝的重量配比为300-350、所述黄芪的重量配比为130-150、所述延胡索的重量配比为60-70、所述当归的重量配比为50-80、所述人参的重量配比为50-80、所述白术的重量配比为60-70、所述茯苓的重量配比为60-70、所述龙眼肉的重量配比为60-70、所述酸枣仁的重量配比为60-70、所述石菖蒲的重量配比为60-70、所述远志的重量配比为60-70、所述五味子的重量配比为300-350、所述麦冬的重量配比为60-70、所述丹参的重量配比为60-70、所述川芎的重量配比为60-70、所述木香的重量配比为60-70，所述缬草的重量配比为60-70、所述柴胡的重量配比为60-70。
优选的，所述绞股蓝的重量配比为325、所述黄芪的重量配比为140、所述延胡索的重量配比为65、所述当归的重量配比为75、所述人参的重量配比为60、所述白术的重量配比为68、所述茯苓的重量配比为64、所述龙眼肉的重量配比为63、所述酸枣仁的重量配比为66、所述石菖蒲的重量配比为61、所述远志的重量配比为69、所述五味子的重量配比为330、所述麦冬的重量配比为68、所述丹参的重量配比为68、所述川芎的重量配比为65、所述木香的重量配比为67，所述缬草的重量配比为62、所述柴胡的重量配比为64。
优选的，所述绞股蓝的重量配比为345、所述黄芪的重量配比为145、所述延胡索的重量配比为67、所述当归的重量配比为77、所述人参的重量配比为69、所述白术的重量配比为62、所述茯苓的重量配比为69、所述龙眼肉的重量配比为69、所述酸枣仁的重量配比为60、所述石菖蒲的重量配比为69、所述远志的重量配比为60、所述五味子的重量配比为350、所述麦冬的重量配比为60、所述丹参的重量配比为62、所述川芎的重量配比为69、所述木香的重量配比为61，所述缬草的重量配比为69、所述柴胡的重量配比为69。
一种基于心神安胶囊的中药组合物的其制备方法，包括以下操作步骤：
S1：原料的处理：按照分量分别将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡清洗干净并进行挑选、祛除泥土、非药用部位；
S2：按分量将清洗好后的将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡分别破碎并过筛；
S3：将经过破碎和过筛后的人参、当归、石菖蒲、白术4味药材粉碎成细粉；其余绞股蓝、黄芪、延胡索、茯苓、龙眼肉、酸枣仁、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡14味药材放入同一个提取罐内，在提取罐内加入超过原料8-12倍的水，将水与原料进行充分搅拌，并对原料进行提取，提取次数需两次，第一次提取时间在1-3小时，第二次提取时间在1-2小时，将两次提取出来后的2次药液合并，过滤，对滤液进行减压浓缩至密度1.1-1.3的稠膏；
S4：将粉碎的人参、当归、石菖蒲、白术4味药材细粉加入到S3提取浓缩的稠膏中混合均匀、干燥、粉碎，制成胶囊剂、片剂、散剂、丸剂等任何一种药剂学所说的剂型，即成为本发明的治疗心脾两虚证的产品。
优选的，所述清洗过程中需将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡其中包含的杂物进行去除。
优选的，所述所有所选所用的材料应当全部检验合格，在挑选时要去掉其包含的杂质、非药用部位等，同时洗涤时不要接触地面。
与现有技术相比，本发明具有如下有益效果：
本发明中，此心神安胶囊可提高心脾两虚型患者的临床疗效，调节外周血NK细胞活性，同时能改善T淋巴细胞亚群水平，本发明制备出的心神安胶囊的中药组合物，经过对147例心脾两虚型的患者进行临床观察，经过连续治疗8周，治疗后，本发明制备出的心神安胶囊的中药组合物可提高心脾两虚型CFS患者临床疗效，调节外周血NK细胞活性，改善T淋巴细胞亚群水平，治疗6个疗程后心脾两虚型患者头痛、睡眠质量下降、关节肌肉疼痛和记忆力减退临床症状、体征消失，本发明制备出的心神安胶囊的中药组合物中的人参、五味子、麦冬、丹参可敛阴滋养、补气生津，黄芪、白术、龙眼肉、远志、木香可补血养气、护心益脾，茯苓、川芎、当归、酸枣仁可清热安神、养心除躁；绞股蓝、石菖蒲、延胡索可醒脑镇静、安神益智，诸药合用，共奏健脾益气、养心安神的功效，同时可治疗阴虚火旺型失眠症疗效确切，可改善患者临床症状，促进其病情康复，同时能有效改善患者中医症候，调节外周血NK细胞活性，改善T淋巴细胞亚群和免疫球蛋白水平，安全性好。
具体实施方式
下面将结合本发明的实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
具体实施例一：
本发明涉及一种心神安胶囊的中药组合物，包括：绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡，绞股蓝的重量配比为300-350、黄芪的重量配比为130-150、延胡索的重量配比为60-70、当归的重量配比为50-80、人参的重量配比为50-80、白术的重量配比为60-70、茯苓的重量配比为60-70、龙眼肉的重量配比为60-70、酸枣仁的重量配比为60-70、石菖蒲的重量配比为60-70、远志的重量配比为60-70、五味子的重量配比为300-350、麦冬的重量配比为60-70、丹参的重量配比为60-70、川芎的重量配比为60-70、木香的重量配比为60-70，缬草的重量配比为60-70、柴胡的重量配比为60-70。
绞股蓝的重量配比为325、黄芪的重量配比为140、延胡索的重量配比为65、当归的重量配比为75、人参的重量配比为60、白术的重量配比为68、茯苓的重量配比为64、龙眼肉的重量配比为63、酸枣仁的重量配比为66、石菖蒲的重量配比为61、远志的重量配比为69、五味子的重量配比为330、麦冬的重量配比为68、丹参的重量配比为68、川芎的重量配比为65、木香的重量配比为67，缬草的重量配比为62、柴胡的重量配比为64。
一种基于心神安胶囊的中药组合物的其制备方法，包括以下操作步骤：
S1：原料的处理：按照分量分别将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡清洗干净并进行挑选、祛除泥土、非药用部位，清洗过程中需将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡其中包含的杂物进行去除，所有所选所用的材料应当全部检验合格，在挑选时要去掉其包含的杂质、非药用部位等，同时洗涤时不要接触地面。
S2：按分量将清洗好后的将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡分别破碎并过筛。
S3：将经过破碎和过筛后的人参、当归、石菖蒲、白术4味药材粉碎成细粉；其余绞股蓝、黄芪、延胡索、茯苓、龙眼肉、酸枣仁、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡14味药材放入同一个提取罐内，在提取罐内加入超过原料8-12倍的水，将水与原料进行充分搅拌，并对原料进行提取，提取次数需两次，第一次提取时间在1-3小时，第二次提取时间在1-2小时，将两次提取出来后的2次药液合并，过滤，对滤液进行减压浓缩至密度1.1-1.3的稠膏。
S4：将粉碎的人参、当归、石菖蒲、白术4味药材细粉加入到S3提取浓缩的稠膏中混合均匀、干燥、粉碎，制成胶囊剂、片剂、散剂、丸剂等任何一种药剂学所说的剂型，即成为本发明的治疗心脾两虚证的产品。
具体实施例二：
本发明涉及一种心神安胶囊的中药组合物，包括：绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡，绞股蓝的重量配比为300-350、黄芪的重量配比为130-150、延胡索的重量配比为60-70、当归的重量配比为50-80、人参的重量配比为50-80、白术的重量配比为60-70、茯苓的重量配比为60-70、龙眼肉的重量配比为60-70、酸枣仁的重量配比为60-70、石菖蒲的重量配比为60-70、远志的重量配比为60-70、五味子的重量配比为300-350、麦冬的重量配比为60-70、丹参的重量配比为60-70、川芎的重量配比为60-70、木香的重量配比为60-70，缬草的重量配比为60-70、柴胡的重量配比为60-70。
绞股蓝的重量配比为345、黄芪的重量配比为145、延胡索的重量配比为67、当归的重量配比为77、人参的重量配比为69、白术的重量配比为62、茯苓的重量配比为69、龙眼肉的重量配比为69、酸枣仁的重量配比为60、石菖蒲的重量配比为69、远志的重量配比为60、五味子的重量配比为350、麦冬的重量配比为60、丹参的重量配比为62、川芎的重量配比为69、木香的重量配比为61，缬草的重量配比为69、柴胡的重量配比为69。
一种基于心神安胶囊的中药组合物的其制备方法，包括以下操作步骤：
S1：原料的处理：按照分量分别将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡进行挑选、祛除泥土、非药用部位，清洗干净并干燥，清洗过程中需将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡其中包含的杂物进行去除，所有所选所用的材料应当全部检验合格，在挑选时要去掉其包含的杂质、非药用部位等，同时洗涤时不要接触地面。
S2：按分量将清洗好后的将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡分别破碎并过筛。
S3：将经过破碎和过筛后的人参、当归、石菖蒲、白术4味药材粉碎成细粉；其余绞股蓝、黄芪、延胡索、茯苓、龙眼肉、酸枣仁、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡14味药材放入同一个提取罐内，在提取罐内加入超过原料8-12倍的水，将水与原料进行充分搅拌，并对原料进行提取，提取次数需两次，第一次提取时间在1-3小时，第二次提取时间在1-2小时，将两次提取出来后的2次药液合并，过滤，对滤液进行减压浓缩至密度1.1-1.3的稠膏。
S4：将粉碎的人参、当归、石菖蒲、白术4味药材细粉加入到S3提取浓缩的稠膏中混合均匀、干燥、粉碎，制成胶囊剂、片剂、散剂、丸剂等任何一种药剂学所说的剂型，即成为本发明的治疗心脾两虚证的产品。
此心神安胶囊可提高心脾两虚型患者的临床疗效，调节外周血NK细胞活性，同时能改善T淋巴细胞亚群水平，本发明制备出的心神安胶囊的中药组合物，经过对147例心脾两虚型的患者进行临床观察，经过连续治疗8周，治疗后，本发明制备出的心神安胶囊的中药组合物可提高心脾两虚型CFS患者临床疗效，调节外周血NK细胞活性，改善T淋巴细胞亚群水平，治疗6个疗程后心脾两虚型患者头痛、睡眠质量下降、关节肌肉疼痛和记忆力减退临床症状、体征消失，本发明制备出的心神安胶囊的中药组合物中的人参、五味子、麦冬、丹参可敛阴滋养、补气生津，黄芪、白术、龙眼肉、远志、木香可补血养气、护心益脾，茯苓、川芎、当归、酸枣仁可清热安神、养心除躁；绞股蓝、石菖蒲、延胡索可醒脑镇静、安神益智，诸药合用，共奏健脾益气、养心安神的功效，同时可治疗阴虚火旺型失眠症疗效确切，可改善患者临床症状，促进其病情康复，同时能有效改善患者中医症候，调节外周血NK细胞活性，改善T淋巴细胞亚群和免疫球蛋白水平，安全性好。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (3)
1.一种心神安胶囊的中药组合物，其特征在于：由如下重量配比的原料制成：绞股蓝300-350、黄芪130-150、延胡索60-70、当归50-80、人参50-80、白术60-70、茯苓60-70、龙眼肉60-70、酸枣仁60-70、石菖蒲60-70、远志60-70、五味子300-350、麦冬60-70、丹参60-70、川芎60-70、木香60-70，缬草60-70、柴胡60-70；
或由：绞股蓝325、黄芪140、延胡索65、当归75、人参60、白术68、茯苓64、龙眼肉63、酸枣仁66、石菖蒲61、远志69、五味子330、麦冬68、丹参68、川芎65、木香67、缬草62、柴胡64；
或由：绞股蓝345、黄芪145、延胡索67、当归77、人参69、白术62、茯苓69、龙眼肉69、酸枣仁60、石菖蒲69、远志60、五味子350、麦冬60、丹参62、川芎69、木香61、缬草69、柴胡69。
2.根据权利要求1所述的一种基于心神安胶囊的中药组合物的制备方法，其特征在于：
包括以下操作步骤：
S1：原料的处理：按照份量分别将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡清洗干净并进行挑选祛除非药用部位；
S2：按份量将清洗好后的将绞股蓝、黄芪、延胡索、当归、人参、白术、茯苓、龙眼肉、酸枣仁、石菖蒲、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡分别破碎并过筛；
S3：将经过破碎和过筛后的人参、当归、石菖蒲、白术4味药材粉碎成细粉；其余绞股蓝、黄芪、延胡索、茯苓、龙眼肉、酸枣仁、远志、五味子、麦冬、丹参、川芎、木香、缬草、柴胡14味药材放入同一个提取罐内，在提取罐内加入超过原料8-12倍的水，将水与原料进行充分搅拌，并对原料进行提取，提取次数需两次，第一次提取时间在1-3小时，第二次提取时间在1-2小时，将两次提取出来后的2次药液合并，过滤，对滤液进行减压浓缩至密度1.1-1.3的稠膏；
S4：将粉碎的人参、当归、石菖蒲、白术4味药材细粉加入到S3提取浓缩的稠膏中混合均匀、干燥、粉碎，制成任何一种药剂学所述的剂型。
3.根据权利要求2所述的一种基于心神安胶囊的中药组合物的制备方法，其特征在于：所述剂型选自胶囊剂、片剂、散剂或丸剂。
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