CN110237182A - 一种缓解体力疲劳的组合物、制备方法和用途 - Google Patents
一种缓解体力疲劳的组合物、制备方法和用途 Download PDFInfo
- Publication number
- CN110237182A CN110237182A CN201910680338.9A CN201910680338A CN110237182A CN 110237182 A CN110237182 A CN 110237182A CN 201910680338 A CN201910680338 A CN 201910680338A CN 110237182 A CN110237182 A CN 110237182A
- Authority
- CN
- China
- Prior art keywords
- parts
- physical fatigue
- composition
- fruit
- dry powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 47
- 239000003814 drug Substances 0.000 claims abstract description 42
- 239000000284 extract Substances 0.000 claims abstract description 41
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 37
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 34
- 235000008434 ginseng Nutrition 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 31
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 30
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 241000830535 Ligustrum lucidum Species 0.000 claims abstract description 16
- 210000000582 semen Anatomy 0.000 claims abstract description 16
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 15
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 14
- 241001278833 Rosa laevigata Species 0.000 claims abstract description 14
- 235000000661 Rosa laevigata Nutrition 0.000 claims abstract description 14
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 14
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 14
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 14
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 241000208340 Araliaceae Species 0.000 claims abstract 6
- 239000000463 material Substances 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 18
- 229940079593 drug Drugs 0.000 claims description 15
- 238000001035 drying Methods 0.000 claims description 15
- 241001247821 Ziziphus Species 0.000 claims description 14
- 239000012535 impurity Substances 0.000 claims description 14
- 238000004140 cleaning Methods 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 7
- 238000007908 dry granulation Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000003595 mist Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000002224 dissection Methods 0.000 claims description 3
- 238000002203 pretreatment Methods 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 235000020985 whole grains Nutrition 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000005498 polishing Methods 0.000 claims description 2
- 241000167854 Bourreria succulenta Species 0.000 claims 1
- 235000019693 cherries Nutrition 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 4
- 238000007905 drug manufacturing Methods 0.000 abstract description 2
- 240000008866 Ziziphus nummularia Species 0.000 abstract 1
- 240000005373 Panax quinquefolius Species 0.000 description 31
- 230000000694 effects Effects 0.000 description 23
- 241000699666 Mus <mouse, genus> Species 0.000 description 18
- 210000003734 kidney Anatomy 0.000 description 14
- 210000004185 liver Anatomy 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 235000009508 confectionery Nutrition 0.000 description 10
- 150000004676 glycans Chemical class 0.000 description 9
- 229920001282 polysaccharide Polymers 0.000 description 9
- 239000005017 polysaccharide Substances 0.000 description 9
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 8
- 241000096284 Gynochthodes officinalis Species 0.000 description 7
- 230000002929 anti-fatigue Effects 0.000 description 7
- 210000000952 spleen Anatomy 0.000 description 7
- 239000009636 Huang Qi Substances 0.000 description 6
- 229940088597 hormone Drugs 0.000 description 6
- 239000005556 hormone Substances 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229930182494 ginsenoside Natural products 0.000 description 4
- 229940089161 ginsenoside Drugs 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 241000005787 Cistanche Species 0.000 description 3
- 241000804384 Cynomorium songaricum Species 0.000 description 3
- 235000017276 Salvia Nutrition 0.000 description 3
- 240000007164 Salvia officinalis Species 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 240000004638 Dendrobium nobile Species 0.000 description 2
- 240000008397 Ganoderma lucidum Species 0.000 description 2
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 2
- 241000892865 Heros Species 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 240000000759 Lepidium meyenii Species 0.000 description 2
- 235000000421 Lepidium meyenii Nutrition 0.000 description 2
- 244000241838 Lycium barbarum Species 0.000 description 2
- 235000015459 Lycium barbarum Nutrition 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 238000009661 fatigue test Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000012902 lepidium meyenii Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 230000009182 swimming Effects 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 241000110637 Cuscuta chinensis Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 235000002722 Dioscorea batatas Nutrition 0.000 description 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 description 1
- 240000001811 Dioscorea oppositifolia Species 0.000 description 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 244000179525 Dracocephalum moldavica Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000009429 Ginkgo biloba extract Substances 0.000 description 1
- 241000256602 Isoptera Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000756042 Polygonatum Species 0.000 description 1
- 235000008737 Polygonatum biflorum Nutrition 0.000 description 1
- 229920001231 Polysaccharide peptide Polymers 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 241001165494 Rhodiola Species 0.000 description 1
- 229910003978 SiClx Inorganic materials 0.000 description 1
- 244000303286 Stachys officinalis Species 0.000 description 1
- 235000009225 Stachys officinalis Nutrition 0.000 description 1
- 240000003186 Stachytarpheta cayennensis Species 0.000 description 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- 244000077233 Vaccinium uliginosum Species 0.000 description 1
- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940068052 ginkgo biloba extract Drugs 0.000 description 1
- 235000020686 ginkgo biloba extract Nutrition 0.000 description 1
- 229930184727 ginkgolide Natural products 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002687 intercalation Effects 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 108010022457 polysaccharide peptide Proteins 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于一种医药技术领域，具体是涉及到一种缓解体力疲劳的组合物、制备方法和用途，包括如下原料组分，人参超微粉10～25％、中药材水提物超微干粉60～80％、二氧化硅1～5％、微晶纤维素5～10％、硬脂酸镁0.1～0.5％；所述中药材水提物超微干粉包括黄精5～8份、淫羊藿2～4份、枸杞子2～4份、女贞子2～4份、菟丝子1～2份、丹参2～4份、金樱子2～4份、大枣2～3份；本发明药物制造成本低廉，见效快，可有效的缓解体力疲劳。
Description
技术领域
本发明属于一种医药技术领域，具体是涉及到一种缓解体力疲劳的组合物、制备方法和用途。
背景技术
随着社会的发展，科技的进步，工作、生活节凑的加快，工作压力与精神压力的逐渐增加，疲劳已成为成年人的一个普遍现象，也成为一个全球性现象。因此研发具有强身健体、缓解体力疲劳的保健产品，是社会的需求、时代的需求，具有重要的经济社会意义。
现代中医认为，疲劳为一个病名，有其病因病机，是临床上常见病、多发病，是必须重视的新病种，归于亚健康范畴，涉及五脏六腑，主要以脾、肝、肾为主。疲劳为元气耗伤之虚证与心理变化或不畅双重因素所致，治疗上不仅要补虚扶正，也应祛疲安神。一方面，补虚固元，滋养机体，虚得补，正则旺，疲劳自除；另一方面，调畅心志，舒心畅意，神得安，心则宁，疲劳可消。
已有研究表明，虫草、当归、肉苁蓉、唐古特青兰、云芝糖肽通过改善心、脑、骨骼肌的缺血、缺氧缓解体力疲劳；银杏黄酮、银杏内酯、构杞多糖、红景天、锁阳、刺五加、马先蒿、乌饭树等通过改善肝脏代谢和酶的活性、抗氧化清除自由基和乳酸缓解体力疲劳；人参皂苷、虫草等通过提高人体激素水平缓解体力疲劳；灵芝、白蚁等通过增加机体的营养物质缓解体力疲劳。
目前市面上缓解体力疲劳的产品良莠不齐，大多围绕虫草、肉苁蓉、灵芝、锁阳、人参等名贵药材，尤其是野生珍稀药材，破坏了药材的自然资源；或大多围绕肉苁蓉、锁阳、人参、玛咖、淫羊藿、巴戟天、刺五加等提高人体激素作用的药材。
已发表的专利也有上百个，如CN 107875216 A公开了一种具有缓解体力疲劳功效的组合物及其制备方法，由人参、黄芪、淫羊藿和巴戟天的混合水提物600～700份、微晶纤维素200～400份、淀粉100～260份、糊精50～150份、蔗糖30～50份和硬脂酸镁5～10份组成，其中最重要的抗疲劳成份人参皂苷在水提过程将大量损失，且人参、淫羊藿、巴戟天均有提高人体激素的作用，三者用量过大，可能引起人体激素失调。CN 103504299 B公开了一种缓解体力疲劳的保健食品，由玛咖粉4～80份、人参粉2～60份、牛磺酸0.6～30份、淫羊藿提取物0.6～30份、山茱萸提取物0.6～30份、巴戟天提取物0.6～30份、二氧化硅0.5～15份、硬脂酸镁0.2～10份组成，玛咖、人参、淫羊藿、巴戟天等均有提高人体激素的作用，用量过大，可能引起人体激素失调。CN108095078 A公开了一种增强免疫力缓解疲劳用组合物及其制备方法，该组合物由西洋参20～40份、黄芪30～60份、黄精30～60份、麦冬20～50份为原料，水提，制成固体颗粒产品、固体粉末饮品或液体饮料，其中最重要的抗疲劳成份人参与人参皂苷在水提过程将大量损失。
增强免疫力的中草药有很多种，比如人参、西洋参、黄芪、麦冬、山药、白芍、党参、当归、冬虫夏草、石斛、鹿茸、地黄等许多中草药，这些药物或多或少都具有增强免疫力的功效，但是想要达到较好的抗疲劳效果，一般需要使用到一些较为昂贵的中草药，比如野生人参、冬虫夏草、石斛，造成成本高昂，难以推广，且药物有效成分较为单一，起效时间较长，一般仅仅作为保健品使用。
发明内容
本发明要解决的技术问题是提供一种缓解体力疲劳的组合物、制备方法和用途，本发明药物制造成本低廉，见效快，可有效的缓解体力疲劳。
本发明的内容包括如下原料组分，人参超微粉10～25％、中药材水提物超微干粉60～80％、二氧化硅1～5％、微晶纤维素5～10％、硬脂酸镁0.1～0.5％；所述中药材水提物超微干粉包括黄精5～8份、淫羊藿2～4份、枸杞子2～4份、女贞子2～4份、菟丝子1～2份、丹参2～4份、金樱子2～4份、大枣2～3份。
优选的，包括如下原料组分，人参超微粉20％、中药材水提物超微干粉70％、二氧化硅3％、微晶纤维素6.6％、硬脂酸镁0.4％。
优选的，所述中药材水提物超微干粉包括黄精6份、淫羊藿3份、枸杞子3份、女贞子3份、菟丝子2份、丹参3份、金樱子3份、大枣2份。
本发明提供一种缓解体力疲劳的组合物的制备方法，包括如下步骤：
1、药材前处理：取人参药材，清洗、除杂、烘干、灭菌、超微粉碎，得人参超微粉；取黄精药材，清洗、除杂、切块；取淫羊藿、枸杞子、女贞子、菟丝子、金樱子和大枣药材除杂；取丹参药材，清洗、除杂、切段；
2、药材提取、浓缩与干燥：将处理后的黄精、淫羊藿、枸杞子、女贞子、菟丝子、丹参、金樱子和大枣的混合物在80℃，真空水提至少2次，第1次料液比为1:(10～15)，提取时间1～2h，第2次料液比1：(5～10)，提取时间0.5～1h；100目筛过滤，合并2次滤液；－0.03～－0.06Mpa、60～90℃减压浓缩成相对密度为1.2～1.3的浸膏；进行真空带式干燥，参数为：-95KPa～-100KPa、加料泵频率7～9Hz、传动频率15～17Hz、涂料频率7～9Hz、输料角度40°、一区温度100～105℃、二区温度80～85℃、冷却区温度25～30℃；
3、超微粉碎：将上述干燥后的提取物干膏于超微粉碎机超微粉碎，粉碎温度-15℃，得到水提物超微干粉；
4、干法制粒：指步骤1所制备的人参超微粉与步骤3所制备的水提物超微干粉于混合机混均，添加二氧化硅、微晶纤维素、硬脂酸镁，混合10～15min，混合均匀；于干法制粒机干法制粒，制粒压力5Mpa，垂直转速18转/min，水平转速48转/min，压辊转速13转/min，整粒转速120转/min，得到缓解体力疲劳的组合物；
优选的，包括如下步骤：将缓解体力疲劳的组合物进行胶囊填充，抛光，得到复方胶囊。
本发明还提供一种缓解体力疲劳的组合物在制备缓解体力疲劳药物方面的用途。
本发明的人参，甘，微苦，微温，归脾、肺、心、肾经；具大补元气、复脉固脱、补脾益肺、生津养血、安神益智功效。
淫羊藿，辛、甘，温，归肝、肾经，具补肾阳、强筋骨、袪风湿功效。枸杞子，甘，平，归肝、肾经，具滋补肝肾，益精明目功效，用于虚劳精亏、腰膝酸育等。
枸杞子，甘，平，归肝、肾经，具滋补肝肾，益精明目功效，用于虚劳精亏、腰膝酸软等。
女贞子，甘、苦，凉，归肝、肾经，具滋补肝肾，明目乌发作用。
菟丝子，辛，甘，闰，归肝、肾、脾经，具补益肝肾、固精缩尿、安胎、明目、止泻作用。
金樱子，酸、甘、涩，平，归肾、膀胱、大肠经，具固精缩尿、固崩止带、涩肠止泻功效。
丹参，苦，微寒，归心、肝经，具活血袪瘀、通经止痛、清心除烦、凉血消痈功效。黄精，甘，平，归脾、肺、肾经；具补气养阴、健脾润肺益肾功效，用于脾胃气虚、体倦乏力、精血不足、腰膝酸软等。
大枣，甘、温，归脾、胃、心经，具补中益气、养血安神之功效。
本发明的有益效果是，本发明配伍、配比科学合理，按传统中药理论结合现代临床医学理论配伍，以人参为君药，补虚固元；以黄精、淫羊藿、枸杞子、女贞子、菟丝子为臣药，滋补肝肾，生津造血，滋养机体；以金樱子、丹参为佐药，通过补气、活血、固精，调节精气血；以大枣为使药，调和诸药。以高效抗疲劳成分人参皂苷为主成份，以具有抗疲劳作用的淫羊藿多糖、枸杞子多糖、女贞子多糖、菟丝子多糖、金樱子多糖、丹参多糖、黄精多糖为辅助成分。
本发明配伍、用量科学合理，本发明所用药材均为人工栽培的大宗药材，所涉及工艺为简单生产工艺，成本低，易于实施、转化。即解决了部份野生珍稀药材的资源保护问题，又避免了过度使用提高人体激素水平药材的副作用问题，还解决了产业化成本问题。
本发明采用-15℃低温超微粉碎，最大程度的保留了人参药材中的皂苷成分，且超微粉极易被人体吸收，又大大提高人参皂苷及营养成份的生物利用度，保证了产品缓解体力疲劳的作用。另外，本发明处方中含有大量粗多糖，疗效好，但生产实施存在困难，药液粘稠，干燥存在困难，喷雾干燥容易堵喷头、粘壁，损耗大，如果采用抽真空干燥，时间长，本发明采用带式干燥，时间短，耗能小，温度相对较低，有效成分损失小。带式干燥收料后，采用-15℃低温超微粉碎，解决浸膏粉碎难题，同时，超微粉极易被人体吸收，又大大提高水提物中多糖及营养的生物利用度，进一步提供了产品缓解体力疲劳的作用。制粒采用干法制粒，区别于湿法制粒，直接制粒，不用再次干燥，减少损耗，减少工序及生产周期。
附图说明
图1为本发明的干颗粒的形貌图。
图2为本发明的胶囊的形貌图。
具体实施方式
实施例1
本实施例的一种缓解体力疲劳的组合物，其原料配比为：人参超微粉10％、黄精等8味药水提物微粉干粉80％、二氧化硅4％、微晶纤维素5.8％、硬脂酸镁0.2％。黄精等8味药水提物微粉干粉为黄精6份、淫羊藿3份、枸杞子3份、女贞子3份、菟丝子2份、丹参3份、金樱子3份、大枣2份的混合物的水提产物。
制备方法为：
①药材前处理：取人参药材，清洗、除杂、烘干、灭菌、超微粉碎，得人参超微粉；取黄精药材，清洗、除杂、切块；取淫羊藿、枸杞子、女贞子、菟丝子、金樱子和大枣药材除杂；取丹参药材，清洗、除杂、切段；
②取处理后的黄精等8味药的混合物80℃、真空水提2次，第1次料液比1:10，提取时间1.5h，第2次料液比1：8，提取时间1h；100目筛过滤，合并2次滤液，－0.03～－0.06Mpa、60～90℃减压浓缩成相对密度为1.3(60℃)的浸膏，-99KPa、加料泵频率8Hz、传动频率16Hz、涂料频率8Hz、输料角度40°、一区温度105℃、二区温度85℃、冷却区温度25～30℃带式干燥。
③取黄精等8味药水提物干膏于超微粉碎机超微粉碎，粉碎温度-15℃，得到超微干粉；
④按比例取人参粉、黄精等8味药水提物干粉、二氧化硅、微晶纤维素、硬脂酸镁于混合机混合10～15min，混合均匀；于干法制粒机干法制粒，制粒压力5Mpa，垂直转速18转/min，水平转速48转/min，压辊转速13转/min，整粒转速120转/min，得到缓解体力疲劳的组合物；
⑤胶囊填充，取干颗粒进行胶囊自动填充、抛光。
本实施例组合物，成人每日2次，每次2粒，空腹服用。
实施例2
本实施例的一种缓解体力疲劳的组合物，其原料配比为：人参超微粉15％、黄精等8味药水提物超微干粉75％、二氧化硅2％、微晶纤维7.5％、硬脂酸镁0.5％。黄精等8味药水提物超微干粉为黄精5份、淫羊藿2份、枸杞子4份、女贞子3份、菟丝子1份、丹参2份、金樱子4份、大枣2份的混合物的水提产物。
制备：同实施例1。
本实施例组合物，成人每日2次，每次2粒，空腹服用。
实施例3
本实施例一种缓解体力疲劳的组合物，其原料配比为：人参超微粉20％、黄精等8味药水提物超微干粉70％、二氧化硅3％、微晶纤维6.6％、硬脂酸镁0.4％。黄精等8味药水提物超微干粉为黄精6份、淫羊藿3份、枸杞子3份、女贞子3份、菟丝子2份、丹参3份、金樱子3份、大枣2份的混合物的水提产物。
制备：同实施例1。本实施例组合物，成人每日2次，每次2粒，空腹服用。
实施例4
本实施例一种缓解体力疲劳的组合物，其原料配比为：人参超微粉25％、黄精等8味药水提物超微干粉65％、二氧化硅3％、微晶纤维6.8％、硬脂酸镁0.2％。黄精等8味药水提物超微干粉为黄精6份、淫羊藿3份、枸杞子3份、女贞子3份、菟丝子2份、丹参3份、金樱子3份、大枣2份的混合物的水提产物。
制备：同实施例1。本实施例组合物，成人每日2次，每次2粒，空腹服用。
对比例1
一种缓解体力疲劳的组合物，其原料配比为：西参粉20％、中药水提物干粉70％、二氧化硅3％、微晶纤维素6.6％、硬脂酸镁0.4％。中药水提物干粉为黄精6份、淫羊藿3份、枸杞子3份、黄芪3份、丹参3份、巴戟天3份、冬虫夏草2份的混合物的水提产物。
制备方法为：
①取西洋参药材，清洗、除杂、烘干、粗粉，过80目筛，灭菌；取黄精药材，清洗、除杂、切块；取淫羊藿、枸杞子、黄芪、巴戟天、冬虫夏草药材除杂；取丹参药材，清洗、除杂、切段。
②取处理后的黄精、淫羊藿、枸杞子、黄芪、丹参、巴戟天和冬虫夏草的混合物80℃、真空水提2次，第1次料液比1:10，提取时间1.5h，第2次料液比1：8，提取时间1h；合并2次滤液，减压浓缩成相对密度为1.1(60℃)的浸膏，低温带式干燥。
③取上述中药水提物干粉干膏低温粉碎。
④按比例取西洋参粉、中药水提物干粉、二氧化硅、微晶纤维素、硬脂酸镁混合均匀，干法制粒。
⑤胶囊填充，取干颗粒进行胶囊自动填充、抛光。
本实施例组合物，成人每日2次，每次2粒，空腹服用。
实验例1
为了证明本发明公开的组合物具有较好的缓解体力疲劳作用，本发明以实施例3制得的组合物进行了如下的抗疲劳试验：
以昆明种小鼠为实验对象，选用18～22g的健康小鼠20只，雌雄各10只，分为五组，每组两只雌两只雄：
第1组为空白组；
第2组为每天喂服一次实施例3，1次1粒，连续喂养30天；
第3组为每天喂服两次实施例3，1次2粒，连续喂养30天；
第4组为每天喂服两次实施例3，1次3粒，连续喂养30天；
第5组为每天喂服两次实施例3，1次4粒，连续喂养30天。
①负重游泳试验
未次给药后30min，同时将五组小鼠投入到25℃的温水中，鼠尾根部捆上体重5％的石块，记录小鼠坚持的时间，结果如表1所示。
表1 不同剂量小鼠的平均负重游泳时间表
| 第1组 | 第2组 | 第3组 | 第4组 | 第5组 | |
| 平均负重游泳时间(s) | 252 | 340 | 720 | 760 | 790 |
②跑步试验
未次给药后30min，同时将五组小鼠置于转动鼠笼中，记录小鼠跑动时间及休息次数，结果见表2所示。
表2 不同剂量小鼠的跑步试验数据表
| 第1组 | 第2组 | 第3组 | 第4组 | 第5组 | |
| 平均跑步时间(min) | 39 | 63 | 112 | 122 | 135 |
| 平均休息次数 | 3 | 3 | 2 | 2 | 2 |
由表1和表2可以看出，第1-5组的小鼠，耐力和体力都是逐渐增加的，说明本发明所制备的组合物具有较好的缓解体力疲劳的作用。综合考虑第3-5组的增幅与成本，选择第3组为服用剂量。
实验例2
为了证明本发明公开的组合物在缓解体力疲劳作用方面见效快，本发明以实施例3制得的组合物和对比例1的组合物进行了如下的抗疲劳试验：
以昆明种小鼠为实验对象，选用18～22g的健康小鼠40只，雌雄各20只，分为二组，每组十只雌十只雄：
第6组为喂服一次实施例3药物，1次4粒；
第7组为喂服一次对比例1药物，1次4粒。
①负重游泳试验
给药后30min、1h、3h、5h、10h、1天和2天，同时将2组小鼠投入到25℃的温水中，鼠尾根部捆上体重5％的石块，记录小鼠坚持的时间，结果如表3所示。
表3 小鼠的平均负重游泳时间表
| 0.5h | 1h | 3h | 5h | 10h | 1天 | 2天 | |
| 第六组平均负重游泳时间(s) | 234 | 325 | 334 | 327 | 305 | 215 | 206 |
| 第七组平均负重游泳时间(s) | 221 | 310 | 322 | 325 | 297 | 211 | 202 |
②跑步试验
给药后30min，同时将二组小鼠置于转动鼠笼中，记录小鼠跑动时间及休息次数，结果见表4所示。
表4 不同剂量小鼠的跑步试验数据表
| 第6组 | 第7组 | |
| 平均跑步时间(min) | 65 | 43 |
| 平均休息次数 | 3 | 3 |
由表3和表4可以看出，第6组的小鼠，在给药后半小时后的耐力和体力都明显优于第7组的小鼠，其高峰时期的峰值数据都差不多，所能影响的时间也差不多，证明本发明药物和对比例1的药物具有相当的长期疗效，但是本发明的药物的见效速度更快。
Claims (6)
1.一种缓解体力疲劳的组合物，其特征是，包括如下原料组分，人参超微粉10～25％、中药材水提物超微干粉60～80％、二氧化硅1～5％、微晶纤维素5～10％、硬脂酸镁0.1～0.5％；所述中药材水提物超微干粉包括黄精5～8份、淫羊藿2～4份、枸杞子2～4份、女贞子2～4份、菟丝子1～2份、丹参2～4份、金樱子2～4份、大枣2～3份。
2.如权利要求1所述的缓解体力疲劳的组合物，其特征是，包括如下原料组分，人参超微粉20％、中药材水提物超微干粉70％、二氧化硅3％、微晶纤维素6.6％、硬脂酸镁0.4％。
3.如权利要求1或2所述的缓解体力疲劳的组合物，其特征是，所述中药材水提物超微干粉包括黄精6份、淫羊藿3份、枸杞子3份、女贞子3份、菟丝子2份、丹参3份、金樱子3份、大枣2份。
4.一种如权利要求1、2或3所述的缓解体力疲劳的组合物的制备方法，其特征是，包括如下步骤：
①药材前处理：取人参药材，清洗、除杂、烘干、灭菌、超微粉碎，得人参超微粉；取黄精药材，清洗、除杂、切块；取淫羊藿、枸杞子、女贞子、菟丝子、金樱子和大枣药材除杂；取丹参药材，清洗、除杂、切段；
②药材提取、浓缩与干燥：将处理后的黄精、淫羊藿、枸杞子、女贞子、菟丝子、丹参、金樱子和大枣的混合物在80℃，真空水提至少2次，第1次料液比为1:(10～15)，提取时间1～2h，第2次料液比1：(5～10)，提取时间0.5～1h；100目筛过滤，合并2次滤液；－0.03～－0.06Mpa、60～90℃减压浓缩成相对密度为1.20～1.30的浸膏；进行真空带式干燥，参数为：-95KPa～-100KPa、加料泵频率7～9Hz、传动频率15～17Hz、涂料频率7～9Hz、输料角度40°、一区温度100～105℃、二区温度80～85℃、冷却区温度25～30℃；
③超微粉碎：将上述干燥后的提取物干膏于超微粉碎机超微粉碎，粉碎温度-15℃，得到超微干粉；
④干法制粒：指步骤1所制备的人参超微粉与步骤3所制备的水提物超微干粉于混合机混均，添加二氧化硅、微晶纤维素、硬脂酸镁，混合10～15min，混合均匀；于干法制粒机干法制粒，制粒压力5Mpa，垂直转速16～20转/min，水平转速45～50转/min，压辊转速12～15转/min，整粒转速110～130转/min，得到缓解体力疲劳的组合物。
5.如权利要求4所述的制备方法，其特征是，包括如下步骤：将缓解体力疲劳的组合物进行胶囊填充，抛光，得到复方胶囊。
6.一种如权利要求1-3任一项所述的缓解体力疲劳的组合物在制备缓解体力疲劳药物方面的用途。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910680338.9A CN110237182B (zh) | 2019-07-26 | 2019-07-26 | 一种缓解体力疲劳的组合物、制备方法和用途 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910680338.9A CN110237182B (zh) | 2019-07-26 | 2019-07-26 | 一种缓解体力疲劳的组合物、制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110237182A true CN110237182A (zh) | 2019-09-17 |
| CN110237182B CN110237182B (zh) | 2021-10-01 |
Family
ID=67893568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910680338.9A Active CN110237182B (zh) | 2019-07-26 | 2019-07-26 | 一种缓解体力疲劳的组合物、制备方法和用途 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110237182B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407851A (zh) * | 2020-05-29 | 2020-07-14 | 湖南新汇制药股份有限公司 | 一种中药组合物、制备方法及其在制备抗疲劳药物中的用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547171A (zh) * | 2014-12-25 | 2015-04-29 | 湖南炎帝生物工程有限公司 | 一种缓解体力疲劳的中药组合物、制备方法和应用 |
| CN104547523A (zh) * | 2014-12-31 | 2015-04-29 | 贵州泰尔医药研究所 | 一种增强免疫力的药物及其制备方法 |
-
2019
- 2019-07-26 CN CN201910680338.9A patent/CN110237182B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547171A (zh) * | 2014-12-25 | 2015-04-29 | 湖南炎帝生物工程有限公司 | 一种缓解体力疲劳的中药组合物、制备方法和应用 |
| CN104547523A (zh) * | 2014-12-31 | 2015-04-29 | 贵州泰尔医药研究所 | 一种增强免疫力的药物及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 蔡璐等: "人参超微粉与细粉的体外溶出度比较", 《南方医科大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407851A (zh) * | 2020-05-29 | 2020-07-14 | 湖南新汇制药股份有限公司 | 一种中药组合物、制备方法及其在制备抗疲劳药物中的用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110237182B (zh) | 2021-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1951481A (zh) | 一种治疗脑血栓的药物 | |
| CN102178867A (zh) | 一种益气健脾补肾的中药方剂及其制品 | |
| CN104524424A (zh) | 一种美容排毒祛斑口服液及其制备方法 | |
| KR20160119999A (ko) | 동의보감 원문에 근거한 국산 유기농 공진단 및 이의 제조방법 | |
| CN106377646A (zh) | 一种六味地黄颗粒剂及其制备方法 | |
| CN102406714B (zh) | 一种有助于通便的药物组合物及其制备方法 | |
| CN110237182A (zh) | 一种缓解体力疲劳的组合物、制备方法和用途 | |
| CN108355088A (zh) | 一种改善睡眠质量的酸枣仁药酒及其制备方法 | |
| KR20160000695A (ko) | Dha 함유 기억력 강화 및 피로회복 증진용 한약재 조성물 수능환 및 그 제조방법 | |
| CN105994867A (zh) | 一种具有提高免疫力的巧克力及其制备方法 | |
| CN105146649A (zh) | 一种具有益脾健胃功效的玫瑰花复方中草药保健饮料 | |
| CN104906366A (zh) | 一种治疗月经后期的药物制剂 | |
| CN1181966A (zh) | 一种治疗老年痴呆的药物及其制备方法 | |
| CN113018404A (zh) | 一种血瘀体质保健固体饮料及其制备方法 | |
| CN101843740B (zh) | 一种治疗更年期综合症的中药 | |
| CN1125580A (zh) | 抗衰老中成药 | |
| CN116251152B (zh) | 用于生发乌发的中药组合物、中药制剂的制备方法以及应用 | |
| CN103816433B (zh) | 一种治疗气虚型便秘的中药 | |
| CN109170747A (zh) | 一种养生中药蜂蜜及其制备方法 | |
| CN109170744A (zh) | 一种养生中药蜂蜜及其制备方法 | |
| CN104027535A (zh) | 中药复方组合物 | |
| CN105748735A (zh) | 一种治疗卵巢囊肿的药物组合物及其制备方法 | |
| CN105167078A (zh) | 一种益脾健胃玫瑰花保健饮料 | |
| CN109954082A (zh) | 养颜回春茶及其制备方法 | |
| CN1415363A (zh) | 五加生化药及其制造方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |