CN109172785A - 一种琥枣宁神胶囊及其制备方法 - Google Patents

一种琥枣宁神胶囊及其制备方法 Download PDF

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CN109172785A
CN109172785A CN201811034470.4A CN201811034470A CN109172785A CN 109172785 A CN109172785 A CN 109172785A CN 201811034470 A CN201811034470 A CN 201811034470A CN 109172785 A CN109172785 A CN 109172785A
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radix
amber
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mind
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葛健文
葛庭含
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Tianshui Hospital Of Traditional Chinese Medicine
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Abstract

本发明公开了一种琥枣宁神胶囊及其制备方法，琥枣宁神胶囊按重量份计包括以下组分：龙眼肉12‑18份、夜交藤18‑22份、苦荞12‑18份、丹参10‑15份、琥珀3‑6份、茯神10‑15份、白术8‑10份、酸枣仁12‑18份、桔梗8‑12份、远志8‑12份、五味子8‑12份、木香3‑6份、赤芍12‑18份、柴胡10‑15份、当归10‑15份、生姜8‑10份、半夏8‑10份、苏子10‑15份、香附15‑20份、甘草8‑12份、黄连2‑5份、陈皮3‑5份，本发明所得中药组合物具有宁神宣肺，化痰定志，活血的功效，主治：痰火扰心，心血不足所致的失眠难寐，心烦心悸，胸闷，健忘等因失眠症、抑郁症症见上述证状者。制作简单，服用方便，且无毒副作用。

Description

一种琥枣宁神胶囊及其制备方法
技术领域
本发明涉及中药领域，尤其是涉及一种琥枣宁神胶囊及其制备方法。
背景技术
不寐属于现代医学的失眠症，是现代社会睡眠障碍性疾病中患病率最高的一种，由于诊断标准的不同，报道的流行病学资料差别较大，约10％-50％不等。
现代医学治疗本病措施有：(1)以镇静安眠药为主，较常用的有苯二氮类和非苯二氮类催眠药物。美国睡眠障碍联合会曾推荐非苯二氮类催眠药物可作为原发性失眠的首选药物，并建议“按需用药”和“间断性用药”原则，但目前尚无成熟的间断治疗模式，且尚无一种药物完全符合理想催眠药要求。(2)其他类药物是褪黑激素和一些镇静作用较强的新型抗抑郁药。因褪黑激素替代疗法的疗效并不确切，且在超过生理剂量时会抑制内源性褪黑素的分泌，可能有加重抑郁的倾向，不推荐作为失眠症治疗的一线用药。曲唑酮和米氮平是近年开始使用的新型镇静性抗抑郁药，但曲唑酮导致嗜睡和直立性低血压的发生率较高，使其应用受到一定限制。米氮平改善睡眠的作用随着用药时间的延长，抗组胺产生的镇静作用会发生耐受，其治疗效果会有所降低。但此两种药没有依赖性，可以有效治疗苯二氮类药物依赖后的焦虑、抑郁及戒断症状。(3)非药物疗法主要包括认知行为治疗及各种物理疗法，这些治疗方法基本没有副作用和成瘾性，远期效果较好，但起效较慢，需要专业人员及患者的配合，耗费较多的人力和时间等。大量的临床研究证实了认知行为治疗的有效性和持久性，但一年以上的研究报道尚不多见，在不牺牲疗效的同时如何加强患者治疗的依从性也是有待研究的问题之一。
西医医治失眠症方法虽然起效快、作用强，但存在一定的副作用或潜在的成瘾性，并且部分药品价格高或疗效不稳定，而中医药以其辨证治疗、疗效稳定、价格低廉，能明显改善患者睡眠时间及质量，只有轻微或无成瘾性，不良反应轻，不易复发等特点，逐渐成为治疗失眠症的首选疗法。
发明内容
本发明为克服上述情况不足，旨在提供一种能解决上述问题的技术方案。
一种琥枣宁神胶囊，按重量份计包括以下组分：龙眼肉12-18份、夜交藤18-22份、苦荞12-18份、丹参10-15份、琥珀3-6份、茯神10-15份、白术8-10份、酸枣仁12-18份、桔梗8-12份、远志8-12份、五味子8-12份、木香3-6份、赤芍12-18份、柴胡10-15份、当归10-15份、生姜8-10份、半夏8-10份、苏子10-15份、香附15-20份、甘草8-12份、黄连2-5份、陈皮3-5份。
作为本发明进一步的方案：一种琥枣宁神胶囊，按重量份计包括以下组分：龙眼肉12份、夜交藤18份、苦荞12份、丹参10份、琥珀3份、茯神10份、白术8份、酸枣仁12份、桔梗8份、远志8份、五味子8份、木香3份、赤芍12份、柴胡10份、当归10份、生姜8份、半夏8份、苏子10份、香附15份、甘草8份、黄连2份、陈皮3份。
作为本发明进一步的方案：一种琥枣宁神胶囊，按重量份计包括以下组分：龙眼肉18份、夜交藤22份、苦荞18份、丹参15份、琥珀6份、茯神15份、白术10份、酸枣仁18份、桔梗12份、远志12份、五味子12份、木香6份、赤芍18份、柴胡15份、当归15份、生姜10份、半夏10份、苏子15份、香附20份、甘草12份、黄连5份、陈皮5份。
作为本发明进一步的方案：一种琥枣宁神胶囊，按重量份计包括以下组分：龙眼肉14份、夜交藤19份、苦荞16份、丹参13份、琥珀4份、茯神11份、白术9份、酸枣仁15份、桔梗12份、远志10份、五味子10份、木香5份、赤芍16份、柴胡14份、当归13份、生姜9份、半夏9份、苏子14份、香附17份、甘草10份、黄连4份、陈皮4份。
作为本发明进一步的方案：一种琥枣宁神胶囊的制备方法，包括以下步骤：称取龙眼肉、夜交藤、苦荞、丹参、琥珀、茯神、白术、酸枣仁、桔梗、远志、五味子、木香、赤芍、柴胡、当归、生姜、半夏、苏子、香附、甘草、黄连、陈皮中药饮片，其中琥珀粉碎成细粉，备用；黄连、五味子、远志、夜交藤、丹参先加70％乙醇提取1次，10倍量/2小时，醇提的药液单独减压回收乙醇，至相对密度为1.06～1.08(70℃)的清膏；药渣再加入龙眼肉、苦荞、丹参、茯神、白术、酸枣仁、桔梗、木香、赤芍、柴胡、当归、生姜、半夏、苏子、香附、甘草、陈皮，加水煎煮二次，第一次10倍水/2小时，第二次8倍水/1小时，合并煎液，滤过，滤液浓缩至相对密度为1.07～1.09(80℃)的清膏，合并醇提与水提的清膏，喷雾干燥(进风温度160℃～180℃，出风温度85℃～95℃)，粉碎成细粉，过筛，加入琥珀细粉混匀、麦芽糊精适量，干压制粒，然后再加入硬脂酸镁适量，装胶囊，0.4g/粒。
本发明的有益效果：本发明所得中药组合物具有宁神宣肺，化痰定志，活血的功效，主治：痰火扰心，心血不足所致的失眠难寐，心烦心悸，胸闷，健忘等因失眠症、抑郁症症见上述证状者。制作简单，服用方便，且无毒副作用。
本发明的附加方面和优点将在下面的描述中部分给出，部分将从下面的描述中变得明显，或通过本发明的实践了解到。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本发明实施例1中，一种琥枣宁神胶囊，按重量份计包括以下组分：龙眼肉12-18份、夜交藤18-22份、苦荞12-18份、丹参10-15份、琥珀3-6份、茯神10-15份、白术8-10份、酸枣仁12-18份、桔梗8-12份、远志8-12份、五味子8-12份、木香3-6份、赤芍12-18份、柴胡10-15份、当归10-15份、生姜8-10份、半夏8-10份、苏子10-15份、香附15-20份、甘草8-12份、黄连2-5份、陈皮3-5份。
本发明实施例2中，一种琥枣宁神胶囊，按重量份计包括以下组分：龙眼肉12份、夜交藤18份、苦荞12份、丹参10份、琥珀3份、茯神10份、白术8份、酸枣仁12份、桔梗8份、远志8份、五味子8份、木香3份、赤芍12份、柴胡10份、当归10份、生姜8份、半夏8份、苏子10份、香附15份、甘草8份、黄连2份、陈皮3份。
本发明实施例3中，一种琥枣宁神胶囊，按重量份计包括以下组分：龙眼肉18份、夜交藤22份、苦荞18份、丹参15份、琥珀6份、茯神15份、白术10份、酸枣仁18份、桔梗12份、远志12份、五味子12份、木香6份、赤芍18份、柴胡15份、当归15份、生姜10份、半夏10份、苏子15份、香附20份、甘草12份、黄连5份、陈皮5份。
本发明实施例4中，一种琥枣宁神胶囊，按重量份计包括以下组分：龙眼肉14份、夜交藤19份、苦荞16份、丹参13份、琥珀4份、茯神11份、白术9份、酸枣仁15份、桔梗12份、远志10份、五味子10份、木香5份、赤芍16份、柴胡14份、当归13份、生姜9份、半夏9份、苏子14份、香附17份、甘草10份、黄连4份、陈皮4份。
当归、龙眼肉均为甘温之品，奏补血养心之效，茯神、远志、酸枣仁皆为宁心安神之品，茯神安心神有良效，远志交心肾又滋养心之阴血，酸枣仁养心肝而化生气血，木香辛香，为善调气机之枢，佐治以理气醒脾；黄连苦寒降泄，入心经而功专清泻中焦之火，又因痰湿多并存，半夏为化痰之要药，燥湿化痰，消痞散结和胃；生姜杀半夏而制约其毒；方中琥珀古称虎魄、兽魂。甘平，入心肝膀胱经。定惊安神，散瘀止血，利水通淋之功。《别录》谓“主安五脏，定魂魄，消瘀血，通五淋”酸枣仁味酸甘，性平，入心、肝、脾、胆四经。具有养心安神之效。《本经》云“主治心腹寒热邪结气，四肢酸疼，湿痹。”方中以琥珀酸枣仁养心宁神为君药；重用桔梗，其性平，味苦辛，归肺经，作为舟楫之剂，具有宣肺祛痰，调理气机，载药上行入心之功效，我们在临床上汤剂中重用桔梗30g时，安眠作用非常显著，并且未见不良反应；柴胡辛苦凉，归肝、胆、脾、胃、三焦经，具有疏肝解郁、和解泄热，升阳举陷之功。为少阳经要药，功擅疏肝理气。具有镇静抗抑郁作用。多项实验证明，多种柴胡的制剂以及柴胡的根、果实中提取的柴胡粗皂甙及柴胡皂甙元A等均有明显镇静作用，小鼠口服柴胡粗皂甙200～800mg即可出现镇静作用；丹参味苦，性微寒。功能活血化瘀，凉血安神，归心、心包、肝经；夜交藤性平，味甘，归心、肝经，能养心安神，祛风通络，补益心肾。具有改善睡眠的活性成分；五味子甘酸辛苦咸五味俱全，入心肺经，具有补气宁心，益智安神敛涩之效。具有镇静催眠作用，与夜交藤共为使药；苏子降气消痰，止咳平喘，润肠通便。用于痰壅气逆，咳嗽气喘，肠燥便秘；香附疏肝解郁，理气宽中；苦荞味甘、性凉，有清热解毒、益气宽肠之功效；甘草与白术同用，用于心气虚；诸药辛酸相伍，散敛有致，治节得权，共奏宁神宣肺，化痰定志之功效。
一种琥枣宁神胶囊的制备方法，包括以下步骤：称取龙眼肉、夜交藤、苦荞、丹参、琥珀、茯神、白术、酸枣仁、桔梗、远志、五味子、木香、赤芍、柴胡、当归、生姜、半夏、苏子、香附、甘草、黄连、陈皮中药饮片，其中琥珀粉碎成细粉，备用；黄连、五味子、远志、夜交藤、丹参先加70％乙醇提取1次，10倍量/2小时，醇提的药液单独减压回收乙醇，至相对密度为1.06～1.08(70℃)的清膏；药渣再加入龙眼肉、苦荞、丹参、茯神、白术、酸枣仁、桔梗、木香、赤芍、柴胡、当归、生姜、半夏、苏子、香附、甘草、陈皮，加水煎煮二次，第一次10倍水/2小时，第二次8倍水/1小时，合并煎液，滤过，滤液浓缩至相对密度为1.07～1.09(80℃)的清膏，合并醇提与水提的清膏，喷雾干燥(进风温度160℃～180℃，出风温度85℃～95℃)，粉碎成细粉，过筛，加入琥珀细粉混匀、麦芽糊精适量，干压制粒，然后再加入硬脂酸镁适量，装胶囊，0.4g/粒。
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。

Claims (5)

1.一种琥枣宁神胶囊，其特征在于，按重量份计包括以下组分：龙眼肉12-18份、夜交藤18-22份、苦荞12-18份、丹参10-15份、琥珀3-6份、茯神10-15份、白术8-10份、酸枣仁12-18份、桔梗8-12份、远志8-12份、五味子8-12份、木香3-6份、赤芍12-18份、柴胡10-15份、当归10-15份、生姜8-10份、半夏8-10份、苏子10-15份、香附15-20份、甘草8-12份、黄连2-5份、陈皮3-5份。
2.根据权利要求1所述的琥枣宁神胶囊，其特征在于，按重量份计包括以下组分：龙眼肉12份、夜交藤18份、苦荞12份、丹参10份、琥珀3份、茯神10份、白术8份、酸枣仁12份、桔梗8份、远志8份、五味子8份、木香3份、赤芍12份、柴胡10份、当归10份、生姜8份、半夏8份、苏子10份、香附15份、甘草8份、黄连2份、陈皮3份。
3.根据权利要求1所述的琥枣宁神胶囊，其特征在于，按重量份计包括以下组分：龙眼肉18份、夜交藤22份、苦荞18份、丹参15份、琥珀6份、茯神15份、白术10份、酸枣仁18份、桔梗12份、远志12份、五味子12份、木香6份、赤芍18份、柴胡15份、当归15份、生姜10份、半夏10份、苏子15份、香附20份、甘草12份、黄连5份、陈皮5份。
4.根据权利要求1所述的琥枣宁神胶囊，其特征在于，按重量份计包括以下组分：龙眼肉14份、夜交藤19份、苦荞16份、丹参13份、琥珀4份、茯神11份、白术9份、酸枣仁15份、桔梗12份、远志10份、五味子10份、木香5份、赤芍16份、柴胡14份、当归13份、生姜9份、半夏9份、苏子14份、香附17份、甘草10份、黄连4份、陈皮4份。
5.根据权利要求1所述的琥枣宁神胶囊的制备方法，其特征在于，包括以下步骤：称取龙眼肉、夜交藤、苦荞、丹参、琥珀、茯神、白术、酸枣仁、桔梗、远志、五味子、木香、赤芍、柴胡、当归、生姜、半夏、苏子、香附、甘草、黄连、陈皮中药饮片，其中琥珀粉碎成细粉，备用；黄连、五味子、远志、夜交藤、丹参先加70％乙醇提取1次，10倍量/2小时，醇提的药液单独减压回收乙醇，至相对密度为1.06～1.08(70℃)的清膏；药渣再加入龙眼肉、苦荞、丹参、茯神、白术、酸枣仁、桔梗、木香、赤芍、柴胡、当归、生姜、半夏、苏子、香附、甘草、陈皮，加水煎煮二次，第一次10倍水/2小时，第二次8倍水/1小时，合并煎液，滤过，滤液浓缩至相对密度为1.07～1.09(80℃)的清膏，合并醇提与水提的清膏，喷雾干燥(进风温度160℃～180℃，出风温度85℃～95℃)，粉碎成细粉，过筛，加入琥珀细粉混匀、麦芽糊精适量，干压制粒，然后再加入硬脂酸镁适量，装胶囊，0.4g/粒。
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