CN115040433B - Stable whitening and antioxidant composition and preparation method thereof - Google Patents
Stable whitening and antioxidant composition and preparation method thereof Download PDFInfo
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- CN115040433B CN115040433B CN202210848518.5A CN202210848518A CN115040433B CN 115040433 B CN115040433 B CN 115040433B CN 202210848518 A CN202210848518 A CN 202210848518A CN 115040433 B CN115040433 B CN 115040433B
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- vitamin
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- laurate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention belongs to the technical field of cosmetics, and in particular relates to application of an additive in increasing moisturizing feel and improving stability of a cosmetic composition containing vitamin C and the cosmetic composition, wherein the additive at least comprises the following components: 1 to 10 weight percent of polyethylene glycol; and 1 to 20% by weight of vitamin C laurate. The invention overcomes the defects of poor stability and weak moisturizing feel of the existing high-content vitamin C cosmetic composition, provides an additive capable of increasing the moisturizing feel of the vitamin C cosmetic composition and improving the stability of the vitamin C cosmetic composition, and develops a stable whitening and antioxidant product.
Description
Technical Field
The invention belongs to the technical field of cosmetics. More particularly, relates to a stable whitening and antioxidation composition and a preparation method thereof.
Background
Vitamin C (also called ascorbic acid, VC) is an acidic hexose derivative, namely diluted alcohol type caprolactone, and has a molecular formula of C 6 H 8 O 6 . Vitamin C has high activity, can effectively inhibit tyrosinase activity as strong antioxidant in cosmetic field, and has effects of whitening skin and resisting aging, but Vc water solution is extremely unstable and is easily subjected to light, heat and O 2 And the like, and reduces the activity thereof.
In addition to being unstable in nature, high concentrations of vitamin C cosmetic compositions can provide an unpleasant application experience, such as an insufficient level of moisturization.
Disclosure of Invention
One of the objects of the present invention is to provide the use of an additive comprising polyethylene glycol for increasing the moisturising feel and improving the stability of a cosmetic composition comprising vitamin C.
In one embodiment of the invention, the use of an additive for improving the stability of vitamin C in an aqueous solution, said additive comprising at least:
1 to 10 weight percent of polyethylene glycol; and
1 to 20% by weight of vitamin C laurate.
The use of polyethylene glycol for stabilizing vitamin C is known, as is the irritation caused by it. However, during the course of the test, the deliberate effect was observed, and in the presence of vitamin C laurate, a small amount of polyethylene glycol was able to stabilize vitamin C in aqueous solution with superior stability, and this synergistic effect was not observed when other vitamin C esters were combined with polyethylene glycol.
In one embodiment of the invention, the use of an additive for increasing the moisturising feel and improving the stability of a cosmetic composition comprising vitamin C, said additive comprising at least:
1 to 10 weight percent of polyethylene glycol;
1 to 20% by weight of vitamin C laurate; and
1 to 10% by weight of vitamin E linoleate.
Surprisingly, it was found that the addition of vitamin E linoleate imparts a stronger moisturizing feel to the high content Vc cosmetic composition, which may be related to the stronger moisturizing effect of vitamin E linoleate, but is distinguished by the fact that the moisturizing feel of the cosmetic composition is improved while the effect of the polyethylene glycol to stabilize vitamin C is not affected, but is enhanced to a small extent, compared to other moisturizing ingredients, which are not observed in other types of moisturizers.
In one embodiment of the present invention, the additive is used for improving the moisturizing feel and improving the stability of a high-content vitamin C cosmetic composition, wherein the weight ratio of vitamin C laurate to polyethylene glycol to vitamin E linoleate is 1:0.1 to 1:0.1 to 1.
The weight ratio for vitamin C laurate, polyethylene glycol and vitamin E linoleate may be 1:0.1 to 1: any ratio between 0.1 and 1, but the amount of vitamin C laurate must be greater than the other two, preferably 1:0.5:0.2, 1:0.2:0.5, 1:0.5:0.5, and most preferably 1:0.2:0.5.
in one embodiment of the present invention, the vitamin C is added in an amount of 1 to 15% by weight to improve the moisturizing feel and stability of a high-vitamin C cosmetic composition. The amount of vitamin C can be any value between 1 and 15 percent, and can be stably stored in the system when the content of the vitamin C is up to 15 percent under the action of the additive.
The invention also provides a stable whitening and antioxidation composition, which at least comprises the following components:
1 to 15 wt% of vitamin C;
1 to 10 weight percent of polyethylene glycol; and
1 to 20% by weight of vitamin C laurate.
For the molecular weight of polyethylene glycol, lower molecular weight stabilizing effect was found to be superior to that of high molecular weight polyethylene glycol (this part of the experimental data is not disclosed), and polyethylene glycol 400 and polyethylene glycol 600, preferably polyethylene glycol 400, are the alternatives.
In one embodiment of the invention, the composition further comprises vitamin E linoleate.
In one embodiment of the present invention, the vitamin E linoleate is added in an amount of 1 to 10% by weight to the composition.
In one embodiment of the present invention, the weight ratio of vitamin C laurate, polyethylene glycol and vitamin E linoleate in the composition is 1:0.1 to 1:0.1 to 1.
The weight ratio for vitamin C laurate, polyethylene glycol and vitamin E linoleate may be 1:0.1 to 1: any ratio between 0.1 and 1, but the amount of vitamin C laurate must be greater than the other two, preferably 1:0.5:0.2, 1:0.2:0.5, 1:0.5:0.5, and most preferably 1:0.2:0.5.
The stable whitening and antioxidant composition of the present invention may be formulated as an essence, a suspension, preferably as an essence.
The stable whitening and antioxidant composition of the present invention may not include oils and fats, and the oils include, but are not limited to, vegetable oils and fats, and synthetic oils and fats, which can also increase the moisturizing feel of vitamin C to some extent, but can maintain good moisturizing feel without adding oils and fats in the composition containing the additive of the present invention.
The stable whitening and antioxidant composition of the present invention may not include other alcohols such as ethoxydiglycol, dipropylene glycol, glycerol, butylene glycol, etc., and although these alcohols can also improve the dissolution stability of vitamin C in aqueous solutions, the composition containing the additive of the present invention can exert satisfactory effect of stabilizing VC without the need of adding additional alcohols. In addition, these alcohols tend to be irritating to the skin, whereas the additives of the present invention, although containing the same alcohols, are less irritating to the skin than the prior art and in the synergy of vitamin C laurate and vitamin E linoleate.
The stable whitening and antioxidant composition of the present invention may include water, and although vitamin C is extremely unstable in aqueous solution, this phenomenon is improved to a great extent after the addition of the additive.
The stable whitening antioxidant composition of the present invention may also include a preservative.
If more efficacy is sought, the composition of the present invention may further comprise other plant efficacy ingredients, plant efficacy ingredients with a maintenance and comfort, plant efficacy ingredients with an antioxidant, plant efficacy ingredients with a moisture retention, etc., as long as the addition of these efficacy ingredients does not affect the stabilizing effect of the additive.
The invention has the following beneficial effects:
the invention overcomes the defects of poor stability and weak moisturizing feel of the existing high-content vitamin C cosmetic composition, provides an additive capable of increasing the moisturizing feel of the vitamin C cosmetic composition and improving the stability of the vitamin C cosmetic composition, and develops a stable whitening and antioxidant product.
Drawings
Fig. 1 shows the results of stability tests of vitamin C in different additive solutions.
Detailed Description
The present invention is further illustrated below with reference to specific examples, which are not intended to limit the invention in any way. Unless specifically stated otherwise, the reagents, methods and apparatus employed in the present invention are those conventional in the art.
Reagents and materials used in the following examples are commercially available unless otherwise specified.
Test example I, research on the influence of additives on the stability of vitamin C
1. Test method
1.1 Preparing Vc standard solution: accurately weighing 0.15g of Vc by an analytical balance, dissolving in distilled water, quantitatively transferring to a 100mL volumetric flask, and diluting with distilled water to a constant volume to prepare a standard stock solution; preparing Vc standard working solution with the concentration of 0.15g/L by adopting standard stock solution; preparing Vc standard application liquid with the concentration of 0.015g/L by adopting standard working liquid; all reagents were ready for use.
1.2 additive solution preparation: accurately weighing VC laurate (called as Vc-laurate) by an analytical balance to prepare 0.2g/L Vc-laurate solution, adding 10mL of 0.15g/L Vc standard working solution, transferring to a 100mL volumetric flask, and adding distilled water to prepare 0.02g/LVc-laurate+0.015g/LVc solution; the preparation of the 0.004g/L PEG+0.015g/LVc solution and the 0.01g/L VE linoleate (hereinafter referred to as VE-La) +0.015g/LVc solution were similar to those described above.
On the basis of the above, 0.02g/L Vc-laurate+0.004g/L PEG+0.015g/LVc solution, 0.02g/L Vc-laurate+0.01g/L Ve-La+0.004g/L PEG+0.015g/LVc solution and 0.02g/L VC palmitate (hereinafter referred to as Vcpalmitate) +0.01g/L Ve-La+0.004g/L PEG+0.015g/LVc solution were continuously prepared.
1.2 absorbance measurement
Taking a proper amount of newly prepared Vc standard application solution and detecting at 265nm wavelength to obtain absorbance A 0h The absorbance of the standard application solution at different time intervals was then separately measured and noted as A 1h 、A 2h 、A 3h …A nh Drawing a standard application solution stability curve by taking time (t) as an abscissa and absorbance (A) as an ordinate; the absorbance of the additive mixture solution prepared in 1.2 was measured at different time intervals under the same conditions and compared with the stability profile of the standard application solution (graph1) The absorbance change rate was calculated (table 1).
1.3 analysis of results
Table 1: effect of different additives on VC absorbance variation
Note that: absorbance change rate (%) = (a) 12h -A 0h )/A 0h ×100％
As can be seen from analysis of fig. 1 and table 1, the absorbance of the 0.015g/L VC aqueous solution is obviously reduced with time, the decrease trend is obvious, the absorbance is reduced by 80.65%, and the VC aqueous solution and its instability are illustrated; the PEG composite VC laurate can obviously delay the oxidation speed of VC, improve the stability of VC, the initial value of the absorbance of the solution is 0.93, the absorbance after 12 hours of standing is 0.80, and the absorbance is only reduced by 13.98 percent; after VE linoleate is continuously added, the effect of stabilizing VC by PEG is not negatively influenced, the initial value of absorbance of the solution reaches 0.98, and the absorbance is reduced by 8.16% after the solution is placed for 12 hours; however, the synergistic effect is not generated after the VC palmitate is adopted to replace the VC laurate, and the absorbance is reduced by 36.62 percent.
Table 2: stable whitening and antioxidant essence
The preparation method comprises the following steps:
mixing the raw materials with water according to the formula shown in Table 2 at room temperature, stirring uniformly, freezing at-5 ℃, balancing for 30min, filtering, and filling to obtain a sample.
Test example two, sample irritation test
The skin irritation/corrosiveness test of products 1# to 8# was referred to in the cosmetic safety technical Specification, 160 persons included in volunteer subjects were randomly divided into 8 groups of 20 persons each, and the test results were as shown in Table 3 below, in accordance with the subject's volunteer selection criteria.
Table 3: skin irritation test results
| Product(s) | Stimulation integral mean value | Stimulus intensity |
| 1# | 0.22 | No irritation |
| 2# | 0.31 | No irritation |
| 3# | 0.36 | No irritation |
| 4# | 0.87 | Light irritation |
| 5# | 1.12 | Light irritation |
| 6# | 0.55 | Light irritation |
| 7# | 0.62 | Light irritation |
| 8# | 0.35 | No stimulation |
Test example III, low temperature stability test
Each group of samples was poured into 2 test tubes, the liquid level was 80mm, a cork was plugged, one of the test tubes was placed in a-15 ℃ refrigerator, and after 24 hours of holding, the test tube was taken out, and after the temperature was returned to room temperature, the test tube was visually compared with the test sample of the other test tube, and the comparison results were shown in table 4 below.
Table 4: low temperature stability test
Test example four, evaluation of moisturizing feel
160 females are selected as test subjects, the average age is 25+/-1 years, the females are randomly divided into 8 groups, each group of test subjects use samples after cleaning the face every night, the test subjects are smeared on the skin, the moisturizing feeling of the product is subjected to sensory evaluation by a 5-minute system, and the evaluation results are shown in the following table 5.
Table 5: moisturizing feel evaluation
| Product(s) | Score value |
| 1# | 4.89±0.68 |
| 2# | 4.63±0.52 |
| 3# | 4.69±0.36 |
| 4# | 2.75±0.28 ** |
| 5# | 2.61±0.33 ** |
| 6# | 3.16±0.14 ** |
| 7# | 2.98±0.21 ** |
| 8# | 3.36±0.26 * |
In contrast to the number 1 of the present invention, * P＜0.05， ** P＜0.01。
the above examples are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above examples, and any other changes, modifications, substitutions, combinations, and simplifications that do not depart from the spirit and principle of the present invention should be made in the equivalent manner, and the embodiments are included in the protection scope of the present invention.
Claims (3)
1. A stable whitening and antioxidant composition, characterized by comprising the following components:
1-15 wt% of vitamin C;
1-10 wt% of polyethylene glycol; and
1-20 wt% of vitamin C laurate;
1-10% by weight of vitamin E linoleate, and
the balance of water.
2. The stable whitening and antioxidant composition according to claim 1, wherein the weight ratio of vitamin C laurate, polyethylene glycol and vitamin E linoleate is 1: 0.1-1: 0.1 to 1.
3. The stable whitening and antioxidant composition according to claim 2, wherein the weight ratio of vitamin C laurate, polyethylene glycol and vitamin E linoleate in the composition is 1:0.2:0.5.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162419A (en) * | 1996-11-26 | 2000-12-19 | Nicholas V. Perricone | Stabilized ascorbyl compositions |
| CN106580755A (en) * | 2017-03-02 | 2017-04-26 | 武汉百思凯瑞纳米科技有限公司 | Nanometer composition containing skin-moistening and whitening components, and preparation method and application thereof |
| CN111557866A (en) * | 2019-02-14 | 2020-08-21 | 株式会社爱茉莉太平洋 | Additive composition for improving use feeling of cosmetics |
| CN111836613A (en) * | 2019-02-14 | 2020-10-27 | 株式会社爱茉莉太平洋 | Additive composition for improving use feeling of cosmetics |
| CN112587438A (en) * | 2020-12-25 | 2021-04-02 | 彭氏(惠州)实业发展有限公司 | Cosmetic composition with high vitamin C content as well as preparation method and application thereof |
| WO2021112398A1 (en) * | 2019-12-06 | 2021-06-10 | (주)이시스코스메틱 | Composition comprising vitamin c |
-
2022
- 2022-07-19 CN CN202210848518.5A patent/CN115040433B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162419A (en) * | 1996-11-26 | 2000-12-19 | Nicholas V. Perricone | Stabilized ascorbyl compositions |
| CN106580755A (en) * | 2017-03-02 | 2017-04-26 | 武汉百思凯瑞纳米科技有限公司 | Nanometer composition containing skin-moistening and whitening components, and preparation method and application thereof |
| CN111557866A (en) * | 2019-02-14 | 2020-08-21 | 株式会社爱茉莉太平洋 | Additive composition for improving use feeling of cosmetics |
| CN111836613A (en) * | 2019-02-14 | 2020-10-27 | 株式会社爱茉莉太平洋 | Additive composition for improving use feeling of cosmetics |
| WO2021112398A1 (en) * | 2019-12-06 | 2021-06-10 | (주)이시스코스메틱 | Composition comprising vitamin c |
| CN112587438A (en) * | 2020-12-25 | 2021-04-02 | 彭氏(惠州)实业发展有限公司 | Cosmetic composition with high vitamin C content as well as preparation method and application thereof |
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