CN115040433A - Stable whitening antioxidant composition and preparation method thereof - Google Patents
Stable whitening antioxidant composition and preparation method thereof Download PDFInfo
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- CN115040433A CN115040433A CN202210848518.5A CN202210848518A CN115040433A CN 115040433 A CN115040433 A CN 115040433A CN 202210848518 A CN202210848518 A CN 202210848518A CN 115040433 A CN115040433 A CN 115040433A
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- laurate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to an application of an additive in increasing the moisturizing feeling and improving the stability of a cosmetic composition containing vitamin C and the cosmetic composition, wherein the additive at least comprises the following components in percentage by weight: 1 to 10% by weight of polyethylene glycol; and 1-20 wt% of vitamin C laurate. The invention overcomes the defects of poor stability and poor moisturizing feeling of the existing cosmetic composition with high vitamin C content, provides an additive capable of increasing the moisturizing feeling and the stability of the cosmetic composition containing vitamin C, and develops a stable whitening and antioxidant product.
Description
Technical Field
The invention belongs to the technical field of cosmetics. More particularly, it relates to a stable whitening antioxidant composition and a preparation method thereof.
Background
Vitamin C (also called ascorbic acid, abbreviated as VC) is an acidic hexose derivative, namely diluted alcohol type hexonic acid lactone with molecular formula C 6 H 8 O 6 . The vitamin C has high activity, can be used as a strong antioxidant in the field of cosmetics, can effectively inhibit tyrosinase activity, has the effects of whitening and resisting aging, but the Vc aqueous solution is extremely unstable and is easy to be subjected to light, heat and O 2 Etc. to decrease its activity.
In addition to being unstable in nature, high concentrations of vitamin C cosmetic compositions can result in an unpleasant application experience, such as an inadequate moisturized feel, when used.
Disclosure of Invention
One of the objects of the present invention is to provide the use of an additive comprising polyethylene glycol for increasing the moisturized feel and improving the stability of a cosmetic composition comprising vitamin C.
In one embodiment of the present invention, the use of an additive for improving the stability of vitamin C in an aqueous solution, said additive comprising at least:
1-10 wt% of polyethylene glycol; and
1-20 wt% of vitamin C laurate.
The use of polyethylene glycol for stabilizing vitamin C is known, as well as its irritation. However, it was unexpectedly observed during the test that a small amount of polyethylene glycol was able to stabilize vitamin C in aqueous solution in the presence of vitamin C laurate, and that this synergistic effect was not observed when other vitamin C esters were combined with polyethylene glycol.
In one embodiment of the present invention, the use of an additive for increasing the moisturized feel and improving the stability of a cosmetic composition comprising vitamin C, said additive comprising at least:
1-10 wt% of polyethylene glycol;
1-20 wt% of vitamin C laurate; and
1-10% by weight of vitamin E linoleate.
It has surprisingly been found that the addition of vitamin E linoleate imparts a strong moisturizing effect to high levels of Vc cosmetic composition, which may be related to a strong moisturizing effect of vitamin E linoleate, but vitamin E linoleate is particularly beneficial in improving the moisturizing effect of cosmetic compositions without affecting the vitamin C stabilizing effect of polyethylene glycol, but rather with a small increase, which is not observed in other moisturizing agents.
In one embodiment of the invention, the additive is used for improving the moisturizing feeling and the stability of a high-vitamin C-content cosmetic composition, and the weight ratio of vitamin C laurate to polyethylene glycol to vitamin E linoleate is 1: 0.1-1: 0.1 to 1.
The weight ratio for vitamin C laurate, polyethylene glycol and vitamin E linoleate may be 1: 0.1-1: any ratio of 0.1-1, but the amount of vitamin C laurate must be greater than the other two, preferably the ratio is 1:0.5:0.2, 1:0.2:0.5, 1:0.5:0.5, and the most preferred ratio is 1:0.2: 0.5.
in one embodiment of the invention, the vitamin C cosmetic composition is used for improving the moisturizing feeling and the stability of a cosmetic composition with high vitamin C content, and the addition amount of the vitamin C in the cosmetic composition is 1-15 wt%. The amount of the vitamin C can be any value between 1 and 15 percent, and the vitamin C can be stably stored in the system when the content of the vitamin C is up to 15 percent under the action of the additive.
The invention also provides a stable whitening and antioxidant composition, which at least comprises the following components:
1-15 wt% of vitamin C;
1-10 wt% of polyethylene glycol; and
1-20 wt% of vitamin C laurate.
For the molecular weight of polyethylene glycol, it was found that lower molecular weight stabilization was superior to higher molecular weight polyethylene glycol (data not disclosed in this section), with polyethylene glycol 400 and polyethylene glycol 600 being preferred, and polyethylene glycol 400 being the most preferred.
In one embodiment of the present invention, the composition further comprises vitamin E linoleate.
In one embodiment of the present invention, the vitamin E linoleate is added in an amount of 1 to 10% by weight in the composition.
In one embodiment of the present invention, the weight ratio of vitamin C laurate, polyethylene glycol and vitamin E linoleate in the composition is 1: 0.1-1: 0.1 to 1.
The weight ratio for vitamin C laurate, polyethylene glycol and vitamin E linoleate can be 1: 0.1-1: 0.1-1, but the amount of vitamin C laurate must be greater than the other two, preferably 1:0.5:0.2, 1:0.2:0.5, 1:0.5:0.5, and most preferably 1:0.2: 0.5.
The stable whitening and antioxidant composition of the present invention can be prepared in the form of essence, suspension, preferably essence.
The stable whitening and antioxidant composition of the invention may not comprise oils and fats, the limited oils include but are not limited to vegetable oils and fats, and synthetic oils and fats, which can increase the moisturizing feeling of vitamin C to some extent, but in the composition containing the additive of the invention, the composition can maintain good moisturizing feeling without adding oil and fat.
The stable whitening and antioxidative composition of the present invention may not include other alcohols such as ethoxydiglycol, dipropylene glycol, glycerin, butylene glycol, etc., and although these alcohols can also improve the solubility stability of vitamin C in an aqueous solution, the composition of the present invention can exert a satisfactory VC-stabilizing effect without the need to additionally add other alcohols. In addition, the alcohols are easy to cause skin irritation, and although the additive of the invention also contains the alcohols, the amount of the alcohols is less than that of the prior art, and the additive is less irritant to the skin under the synergism of the vitamin C laurate and the vitamin E linoleate.
The stable whitening and antioxidant composition of the present invention may include water, and although vitamin C is extremely unstable in an aqueous solution, this phenomenon is greatly improved by the addition of additives.
The stable whitening and antioxidant composition of the invention can also comprise a preservative.
If more efficacies are pursued, the composition of the present invention may further include other plant efficacy ingredients, plant efficacy ingredients with repairing and allergy-relieving effects, plant efficacy ingredients with oxidation resistance, plant efficacy ingredients with moisturizing effects, etc., as long as the addition of these efficacy ingredients does not affect the stabilizing effect of the additive.
The invention has the following beneficial effects:
the invention overcomes the defects of poor stability and poor moisturizing feeling of the existing cosmetic composition with high vitamin C content, provides an additive capable of increasing the moisturizing feeling and the stability of the cosmetic composition containing vitamin C, and develops a stable whitening and antioxidant product.
Drawings
FIG. 1 shows the results of stability tests of vitamin C in various additive solutions.
Detailed Description
The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.
Unless otherwise indicated, reagents and materials used in the following examples are commercially available.
Test example I study on the Effect of additives on vitamin C stability
1. Test method
1.1 Vc standard solution preparation: accurately weighing 0.15g of Vc by an analytical balance, dissolving the Vc in distilled water, quantitatively transferring the Vc to a 100mL volumetric flask, diluting the Vc with the distilled water and carrying out constant volume preparation to obtain a standard stock solution; preparing 0.15g/L of Vc standard working solution by adopting standard stock solution; preparing 0.015g/L of Vc standard application liquid by adopting standard working liquid; all reagents were ready for use.
1.2 preparation of additive solution: VC laurate (hereinafter referred to as Vc-laurate) is accurately weighed by an analytical balance to prepare 0.2g/L Vc-laurate solution, 10mL of 0.15g/L Vc standard working solution is added, then the solution is transferred to a 100mL volumetric flask, and distilled water is added to prepare 0.02g/LVc-laurate +0.015g/LVc solution; the preparation of 0.004g/L PEG +0.015g/LVc solution and 0.01g/L VE linoleate (hereinafter referred to as VE-La) +0.015g/LVc solution was similar to that described above.
On the basis of the above, 0.02g/L Vc-laurate +0.004g/L PEG +0.015g/LVc solution, 0.02g/L Vc-laurate +0.01g/L Ve-La +0.004g/L PEG +0.015g/LVc solution and 0.02g/L VC palmitate (hereinafter referred to as Vcpalmitate) +0.01g/L Ve-La +0.004g/L PEG +0.015g/LVc solution are prepared.
1.2 Absorbance measurement
Taking a proper amount of newly prepared Vc standard application solution, and detecting the absorbance A at the wavelength of 265nm 0h Then the absorbance of the standard application solution at different time intervals is measured separately and recorded as A 1h 、A 2h 、A 3h …A nh Drawing a standard application solution stability curve by taking time (t) as an abscissa and taking absorbance (A) as an ordinate; the absorbance of the additive mixture solution prepared in 1.2 was measured under the same conditions for different time intervals and compared with a standard application solution stability curve (fig. 1), and the absorbance change rate was calculated (table 1).
1.3 analysis of results
Table 1: effect of different additives on the variation of the absorbance of VC
Note: absorbance change (%) - (A) 12h -A 0h )/A 0h ×100％
As can be seen from the analysis of FIG. 1 and Table 1, the absorbance of the 0.015g/L VC aqueous solution is obviously reduced along with the change of time, the descending trend is obvious, the absorbance is reduced by 80.65%, and the Vc aqueous solution and the instability thereof are illustrated; the PEG composite VC laurate can obviously delay the oxidation speed of VC and improve the stability of VC, the initial value of the absorbance of the solution is 0.93, the absorbance after the solution is placed for 12 hours is 0.80, and only 13.98 percent of the absorbance is reduced; after the VE linoleate is continuously added, the effect of stabilizing VC by PEG is not negatively influenced, the initial value of the absorbance of the solution reaches 0.98, and the absorbance is reduced by 8.16% after the solution is placed for 12 hours; but the VC palmitate is adopted to replace the VC laurate, the synergistic effect is not generated, and the absorbance is reduced by 36.62 percent.
Table 2: stable whitening antioxidant essence
The preparation method comprises the following steps:
mixing the raw materials with water at room temperature according to the formula in Table 2, stirring uniformly, freezing at-5 deg.C, balancing for 30min, filtering, and bottling to obtain the sample.
Test example two, sample irritation test
According to the skin irritation/corrosivity test in the technical Specification for cosmetic safety, the irritation of products 1# to 8# to the skin is tested, the skin is included in 160 volunteers, the skin is randomly divided into 8 groups, each group comprises 20 persons, the test result meets the volunteer selection standard of the test subjects, and the test result is shown in the following table 3.
Table 3: results of skin irritation test
| Product(s) | Integral mean of stimulation | Intensity of |
| 1# | 0.22 | Has no |
| 2# | 0.31 | Has no irritation |
| 3# | 0.36 | Has no |
| 4# | 0.87 | Light irritation |
| 5# | 1.12 | |
| 6# | 0.55 | Light irritation |
| 7# | 0.62 | |
| 8# | 0.35 | Has no irritation |
Test example III Low temperature stability test
Each group of samples was poured into 2 test tubes, respectively, so that the liquid level was 80mm, a cork was plugged, one of the test tubes was placed in a refrigerator at-15 ℃, kept for 24 hours, taken out, returned to room temperature, and visually compared with the sample of the other test tube, and the comparison results are shown in Table 4 below.
Table 4: low temperature stability test
Test example four evaluation of moisturizing feeling
160 women were selected as test subjects, the average age was 25 ± 1 year, and the test subjects were randomly divided into 8 groups, and each group of test subjects used samples after cleansing the face every night, and applied to the skin, and sensory evaluation was performed on the moisturizing sensation of the product at 5 points, the evaluation results being shown in table 5 below.
Table 5: evaluation of feeling of moisture
| Product(s) | |
| 1# | 4.89±0.68 |
| 2# | 4.63±0.52 |
| 3# | 4.69±0.36 |
| 4# | 2.75±0.28 ** |
| 5# | 2.61±0.33 ** |
| 6# | 3.16±0.14 ** |
| 7# | 2.98±0.21 ** |
| 8# | 3.36±0.26 * |
Compared with the No. 1, the method has the advantages that, * P＜0.05， ** P＜0.01。
the above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. Use of an additive for increasing the moisturized feel and improving the stability of a cosmetic composition comprising vitamin C, characterized in that said additive comprises at least:
1-10 wt% of polyethylene glycol; and
1-20 wt% of vitamin C laurate.
2. Use according to claim 1, wherein the additive further comprises vitamin E linoleate.
3. The use according to claim 2, wherein the vitamin E linoleate is added in an amount of 1 to 10% by weight in the additive.
4. Use according to claim 3, characterized in that the weight ratio of vitamin C laurate, polyethylene glycol and vitamin E linoleate in the additive is 1: 0.1-1: 0.1 to 1.
5. Use according to any one of claims 1 to 4, wherein vitamin C is added in an amount of 1 to 15% by weight in the cosmetic composition.
6. A stable whitening and antioxidant composition is characterized by at least comprising:
1-15 wt% of vitamin C;
1-10 wt% of polyethylene glycol; and
1-20 wt% of vitamin C laurate.
7. The stable whitening and antioxidant composition of claim 6, further comprising vitamin E linoleate.
8. The stable whitening and antioxidative composition of claim 7, wherein the vitamin E linoleate is added in an amount of 1 to 10 wt%.
9. The stable whitening and antioxidant composition of claim 8, wherein the weight ratio of vitamin C laurate, polyethylene glycol and vitamin E linoleate in the composition is 1: 0.1-1: 0.1 to 1.
10. The stable whitening and antioxidant composition of claim 9, wherein the weight ratio of vitamin C laurate, polyethylene glycol and vitamin E linoleate in the composition is 1:0.2: 0.5.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162419A (en) * | 1996-11-26 | 2000-12-19 | Nicholas V. Perricone | Stabilized ascorbyl compositions |
| CN106580755A (en) * | 2017-03-02 | 2017-04-26 | 武汉百思凯瑞纳米科技有限公司 | Nanometer composition containing skin-moistening and whitening components, and preparation method and application thereof |
| CN111557866A (en) * | 2019-02-14 | 2020-08-21 | 株式会社爱茉莉太平洋 | Additive composition for improving use feeling of cosmetics |
| CN111836613A (en) * | 2019-02-14 | 2020-10-27 | 株式会社爱茉莉太平洋 | Additive composition for improving use feeling of cosmetics |
| CN112587438A (en) * | 2020-12-25 | 2021-04-02 | 彭氏(惠州)实业发展有限公司 | Cosmetic composition with high vitamin C content as well as preparation method and application thereof |
| WO2021112398A1 (en) * | 2019-12-06 | 2021-06-10 | (주)이시스코스메틱 | Composition comprising vitamin c |
-
2022
- 2022-07-19 CN CN202210848518.5A patent/CN115040433B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162419A (en) * | 1996-11-26 | 2000-12-19 | Nicholas V. Perricone | Stabilized ascorbyl compositions |
| CN106580755A (en) * | 2017-03-02 | 2017-04-26 | 武汉百思凯瑞纳米科技有限公司 | Nanometer composition containing skin-moistening and whitening components, and preparation method and application thereof |
| CN111557866A (en) * | 2019-02-14 | 2020-08-21 | 株式会社爱茉莉太平洋 | Additive composition for improving use feeling of cosmetics |
| CN111836613A (en) * | 2019-02-14 | 2020-10-27 | 株式会社爱茉莉太平洋 | Additive composition for improving use feeling of cosmetics |
| WO2021112398A1 (en) * | 2019-12-06 | 2021-06-10 | (주)이시스코스메틱 | Composition comprising vitamin c |
| CN112587438A (en) * | 2020-12-25 | 2021-04-02 | 彭氏(惠州)实业发展有限公司 | Cosmetic composition with high vitamin C content as well as preparation method and application thereof |
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