CN115039873A - Superfine brewing powder for regulating spleen and stomach, and preparation method and application thereof - Google Patents
Superfine brewing powder for regulating spleen and stomach, and preparation method and application thereof Download PDFInfo
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- CN115039873A CN115039873A CN202110222480.6A CN202110222480A CN115039873A CN 115039873 A CN115039873 A CN 115039873A CN 202110222480 A CN202110222480 A CN 202110222480A CN 115039873 A CN115039873 A CN 115039873A
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- spleen
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- stomach
- regulating
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Classifications
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/05—Mashed or comminuted pulses or legumes; Products made therefrom
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Abstract
The invention discloses ultramicro brewing powder for regulating spleen and stomach, a preparation method and application thereof. The ultramicro brewing powder prepared by the scientific formula can be used as a dietotherapy health food for mainly treating weakness of spleen and stomach, short spirit and tasteless diet.
Description
Technical Field
The invention belongs to the field of health-preserving foods, and particularly relates to ultrafine brewing powder for regulating spleen and stomach and a preparation method thereof.
Background
With the continuous improvement of modern living standard, the work rhythm of people is continuously accelerated, and the pressure is increased day by day, so that irregular diet, excessive anxiety, hunger and satiety and the like are caused, and the health of the spleen and the stomach is seriously influenced. The spleen and stomach are the basis of original qi, and the spleen and stomach are injured internally, so that all diseases are caused. The weakness of the spleen and the stomach in traditional Chinese medicine is mainly divided into three types: deficiency of spleen-stomach qi, deficiency of spleen-stomach yang, deficiency of spleen-stomach yin. Deficiency of spleen-stomach qi can cause symptoms such as short breath, asthenia, dizziness, gastrectasia, stomachache, singultus, anorexia, fullness after meal, loose stool, and sallow complexion; the yang deficiency of the spleen and stomach is mainly manifested by cold pain in the stomach and abdomen, and the symptoms of abdominal pain, diarrhea, loose stool and the like can be caused by eating uncooked cold and greasy food; deficiency of spleen-stomach yin is mainly manifested by up-flaming of deficient fire, dry mouth, easy hunger, gastric acid, dull pain and discomfort, sores in the mouth and tongue, etc. This brings great trouble to people's normal work life.
At present, people use traditional Chinese medicines or western medicines to condition the spleen and stomach, but the traditional Chinese medicines or the western medicines have the following problems: the western medicine treatment has more toxic and side effects, the medicine stopping is easy to repeat, and the traditional Chinese medicine has large dosage and slower treatment effect.
As early as 2400 years ago, Huangdi's classic on medicine indicated that "the upper medical science is treating no disease", and "the goddess are not treating disease and are treating no disease", explaining the reason of paying attention to the prevention of disease. In the traditional Chinese culture, the theory of homology of medicine and food is long-flowing, traditional Chinese medicine always stresses that medicine tonifying is not like food tonifying, and the record of food medicine is available in Zhou Li Tian guan in China, so that the food therapy can be used for regulating the spleen and the stomach.
CN 110882367A discloses a prescription medicine for regulating spleen and stomach, which is prepared from 7 traditional Chinese medicines by decocting with water, spraying and drying the decoction, and preparing into granules. CN 109938331A discloses a food formula for invigorating qi and blood, strengthening spleen and stomach, and improving sleep and its preparation method, which comprises 8 kinds of medicinal and edible raw materials, and is prepared into granule or dried bean curd by extraction. CN 111135278A discloses a dietetic therapy formula for recuperating human spleen and stomach with homology of medicine and food, which is prepared from 20 raw materials and prepared into dosage forms of aqua, capsule, oral liquid, tablet and the like. The above patents provide the formula for regulating spleen and stomach through food therapy, but a large amount of excipient is required to be added, the material basis is substantially changed, and the therapeutic effect is greatly influenced; in addition, after the medicinal raw materials are subjected to a complex extraction process, a lot of active ingredients are lost, and the exertion of the drug property of the diet therapy formula is also influenced; in addition, the scientificity and the rationality of the compatibility of the components are to be further questioned, and a certain safety problem exists because part of the raw materials are not derived from the homology of medicine and food.
Disclosure of Invention
The invention aims to provide ultramicro brewing powder for regulating spleen and stomach, which is prepared by adopting an ultralow temperature and ultramicro crushing process, has reasonable formula, homology of medicine and food, no toxic or side effect, furthest reserves volatile components by ultralow temperature treatment and reserves the originality of the basis of medicinal substances.
In order to achieve the purpose, the invention provides the following technical scheme:
the ultrafine mixed powder for regulating the spleen and the stomach is prepared from the following raw materials: white hyacinth bean, Chinese yam, lotus seed, malt, coix seed, gordon euryale seed, tuckahoe and taro.
Preferably, the weight parts of each component are as follows: 15-30 parts of white hyacinth bean, 15-30 parts of Chinese yam, 15-30 parts of lotus seed, 15-30 parts of malt, 15-30 parts of coix seed, 15-30 parts of gordon euryale seed, 15-30 parts of poria cocos and 10-30 parts of taro.
Preferably, the weight parts of each component are as follows: 20-25 parts of white hyacinth bean, 20-25 parts of Chinese yam, 20-25 parts of lotus seed, 20-25 parts of malt, 20-25 parts of coix seed, 20-25 parts of gordon euryale seed, 20-25 parts of poria cocos and 15-25 parts of taro.
Preferably, the ultramicro brewing powder is wall-broken powder, and the particle size of the wall-broken powder is not more than 70 μm.
Preferably, the particle size of the wall-broken powder is 25-55 μm.
The invention also provides a preparation method of the ultrafine mixed powder for regulating the spleen and the stomach, which comprises the following steps:
step 1, coarsely crushing raw materials, and sieving (24-50 meshes) to obtain mixture coarse powder;
step 2, drying the mixture coarse powder obtained in the step 1 at a low temperature (-20 to-10 ℃), and performing ultra-fine grinding at an ultra-low temperature (-35 to-30 ℃) to obtain mixture ultra-fine powder;
and 3, mixing the mixture obtained in the step 2 into superfine powder, and sieving to obtain the wall-broken powder with the particle size of not more than 70 microns.
Preferably, the raw materials are crushed and then mixed.
Preferably, the raw materials are mixed and then pulverized.
On one hand, the food therapy formula for regulating spleen and stomach is provided, the formula is scientific and reasonable, and the food therapy formula is composed of medicinal and edible raw materials; on the other hand, provides a preparation method and clinical application of the ultra-low temperature ultra-micro pulverization technology, and has incomparable advantages: (1) due to the adoption of a wall breaking technology, the particle size reaches 25-55 mu m, so that the dissolution rate of active ingredients is faster, and the bioavailability and the drug effect of the drug are remarkably improved; (2) the whole herbal raw material is used as a medicine, the integrity of all components is kept, and the originality of the drug effect substance basis is kept to the maximum extent; (3) the complex procedures of the traditional decoction are avoided, and the traditional Chinese medicine is convenient, simple and flexible to take; (4) the whole process of the preparation process adopts low-temperature or ultralow-temperature treatment, so that volatile components in the raw materials are retained to the maximum extent; (5) the utilization rate of the medicinal materials is high, and the resources of the Chinese medicinal materials are saved; (6) the safety is high, the raw materials are both medicinal and edible, the disease can be treated, and the essential attributes of natural and comfortable food therapy and no toxic or side effect are met. (7) The carrying and the application are more convenient. The traditional Chinese medicine composition can provide balanced nutrition, has the effects of mainly treating weakness of the spleen and the stomach, short spirit, tasteless diet and the like, has a remarkable curative effect, effectively solves the problems of poor effect, long period, easy relapse after withdrawal, more toxic and side effects and the like of the prior art for regulating the spleen and the stomach, and is worthy of clinical popularization and application. In addition, the invention can also be used for treating chronic gastritis with syndrome of dampness-heat in spleen and stomach.
The source and the function of the bulk drugs are as follows:
white hyacinth bean: also called hyacinth bean, hedgerow bean, and moth bean, is dried white ripe seed of hyacinth bean (Dolichos lablab L.) belonging to Leguminosae family. The book Ben Cao gang mu states that the hyacinth beans regulate the liver and stomach, clear summer-heat and dispel dampness, stop diarrhea, the book Lu Dou she Zhong Xian Qi from Ming Yi Bie Lu records that the hyacinth beans can ascend the clear and descend the turbid, so it has the efficacy of regulating the liver and stomach. The Chinese pharmacopoeia records: white hyacinth bean, [ nature and taste ] sweet, slightly warm; it enters spleen and stomach meridians. [ FUNCTIONS ] can invigorate spleen, eliminate dampness, regulate the middle warmer, and remove summer-heat. Can be used for treating weakness of spleen and stomach, anorexia, diarrhea, leukorrhagia, summer heat, dampness, vomiting and diarrhea, chest distress, and abdominal distention. The white hyacinth bean has high nutritive value, the carbohydrate content is as high as about 57%, and in addition, the white hyacinth bean also contains protein, fat, trace calcium, phosphorus, iron, various vitamins and the like. The white hyacinth bean is clinically applied by 30-60 g, boiled and cooked, and drunk to treat chronic diarrhea and acute gastroenteritis, vomiting and diarrhea caused by spleen deficiency [ the sinus auspicious, the kidney bean for resolving the clear and descending the turbid, the J.TCM (1994), 35(12):755, 756 ].
Chinese yam: is tuber of Dioscorea opposita Thunb (Dioscorea opposita Thunb). The Chinese pharmacopoeia records: chinese yam, rhizoma Dioscoreae, etc.; it enters spleen, lung and kidney meridians. [ FUNCTIONS ] can tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and arrest seminal emission. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat. The Chinese yam is not only a good medicine for tonifying spleen and qi, but also a traditional health food. The Chinese yam nutritional health-care product mainly contains nutritional ingredients such as starch, protein and free amino acid, various active ingredients such as polysaccharide, allantoin, choline and sterols, and some trace elements, and the chemical ingredients form the nutritional value and the activity of the Chinese yam. Research shows that the Chinese yam has the functions of strengthening spleen and stomach, benefiting lung and kidney, lowering blood sugar, resisting senility, regulating immunity, resisting mutation, lowering blood fat, etc. The Chinese yam is a Chinese medicine for tonifying middle-jiao and benefiting qi, and has good regulating effect on the functions of the digestive system of a human body. Experiments on gastrointestinal functions of spleen deficiency model mice are adopted, and the Chinese yam water decoction has strong pharmacological effects on the aspects of inhibiting gastric emptying and intestinal propulsion functions of the spleen deficiency mice [ Chen Lin, Chen and Chua Baochang ] Chinese yam and different polarity parts of water extracts of bran-stir-fried products thereof on the gastrointestinal functions of the spleen deficiency mice. 168-171.].
Lotus seed: is dried mature seed of Nelumbo nucifera Gaertn belonging to Nymphaeaceae. The Chinese pharmacopoeia records: lotus seeds, nature and taste, are sweet, astringent and neutral; it enters spleen, kidney and heart meridians. [ FUNCTIONS ] can tonify spleen, check diarrhea, stop leukorrhagia, tonify kidney, astringe essence, nourish heart, and induce tranquilization. Can be used for treating diarrhea due to spleen deficiency, leukorrhagia, spermatorrhea, palpitation, and insomnia. Lotus seed is a traditional nourishing product, which is rich in nutrition and contains biological active ingredients such as flavonoid, water-soluble polysaccharide, superoxide dismutase (SOD) and the like besides protein, carbohydrate, vitamins, various essential amino acids for human bodies, a large amount of trace elements such as calcium, phosphorus, iron, zinc and the like. Researches show that the lotus seeds have a two-phase regulation effect on gastrointestinal motility of mice, can relieve constipation symptoms and promote the absorption function of small intestines; the gastrointestinal mucosa barrier can also be protected by regulating intestinal flora, enhancing intestinal immunity and the like [ Wu Xiao nan, Chen Jie, Wang Jia Li, and the like. 2535-2539].
Malt: is a germinated and dried processed product of mature fruit of barley (Hordeum vulgare L.) belonging to the family Gramineae. The Chinese pharmacopoeia records: malt, [ sex, taste ] sweet, neutral; it enters spleen and stomach meridians. [ FUNCTIONS ] can promote the circulation of qi, promote digestion, invigorate the spleen, stimulate the appetite, promote lactation and relieve distension. Can be used for treating dyspepsia, abdominal pain, deficiency of spleen-deficiency food, breast milk stagnation, breast pain, breast weaning, hypochondriac pain due to stagnation of liver-qi, and pain of liver and stomach. The malt contains amylase, invertase, esterase, protease, phospholipid, vitamin B, vitamin C, maltose, glucose, and maltodextrins. Clinical application shows that: the water decoction of malt is used for filling the stomach of a patient, so that gastric acid secretion can be slightly increased, and pepsin secretion is also slightly promoted [ hypersensitiveness to the study, and the like. People health press, 2003, 392 ].
Coix seed: is dried mature kernel of Coicis semen (Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.) of Gramineae. The Chinese pharmacopoeia records: semen coicis (nature and taste) is sweet, light and cool; it enters spleen, stomach and lung meridians. [ FUNCTIONS ] has effects of promoting diuresis, eliminating dampness, invigorating spleen, relieving diarrhea, removing arthralgia, expelling pus, removing toxic substance, and resolving hard mass. Can be used for treating edema, loempe, dysuria, spleen deficiency, diarrhea, damp arthralgia, spasm, pulmonary abscess, intestinal abscess, wart, and cancer. Semen Coicis contains fatty acids and esters, coixol, saccharides, flavonoids, glycoproteins, sterols, and lactams. Modern pharmacological research shows that the coix seeds have various pharmacological activities of resisting tumors, resisting inflammation and easing pain, reducing blood sugar, reducing blood pressure, improving the immunity of organisms and the like.
Gorgon fruit: is dried mature kernel of Nymphaeaceae plant Gorgon Euryale ferox Salisb. The Chinese pharmacopoeia records: gorgon fruit, semen euryales (nature and taste) is sweet, astringent and neutral; it enters spleen and kidney meridians. [ FUNCTIONS ] can tonify kidney, arrest spontaneous emission, tonify spleen, arrest diarrhea, remove dampness, and stop leukorrhagia. Can be used for treating spermatorrhea, enuresis, frequent micturition, spleen deficiency, chronic diarrhea, whitish and turbid urine, and leukorrhagia. The semen euryales mainly contains sterol, flavonoid, cyclic peptide, lipid and other components, and has pharmacological effects of resisting oxidation, delaying aging, resisting fatigue, resisting myocardial ischemia, resisting cancer and the like.
Tuckahoe, poria cocos: is dried sclerotium of Poria cocos (Schw.) Wolf) belonging to Polyporaceae. The Chinese pharmacopoeia records: poria cocos, poria cocos (wolf.) wolf, sweet, light and mild; it enters heart, lung, spleen and kidney meridians. [ FUNCTIONS ] has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. Can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. The Shen nong Ben Cao Jing listed as the top grade of 'reducing weight, tonifying qi, not aging and prolonging life'. Poria mainly contains polysaccharides, triterpenes, sterols, etc., and has various biological activities of resisting tumor, regulating immunity, resisting inflammation, resisting oxidation, resisting aging, improving memory, regulating urinary system, lowering blood sugar, reducing blood lipid, tranquilizing, hypnotizing, and protecting liver.
Taro: is tuber of Colocasia esculenta (L.) Schott of Araceae. The taro contains rich starch, protein, dietary fiber, vitamins, mineral substances and other ingredients, and has a soft and sweet taste. Taro is sweet, pungent, mild, and slippery in nature, and toxic when it is used in the intestine and stomach meridians. Has effects in invigorating spleen, regulating intestine and stomach, lowering blood pressure and blood lipid, resisting aging, and enhancing immunity.
The invention has the advantages that: the spleen and stomach are the acquired origin and the source of qi and blood generation, mainly for the reception, transportation, transformation, absorption and metabolism of food, while the spleen qi is powerful in transportation and transformation, the food is refined, and nourishes the five viscera through the function of ascending clear. The traditional Chinese medicine has the dietetic therapy view that five cereals are nourished, five fruits are helped, five animals are benefited, and five vegetables are used as supplements (the 'Huangdi's plain inquiry and Qi-storing method 'theory) and' millet flesh, fruit and vegetable and food are kept completely '(the' Huangdi's plain inquiry and five regular political major theory'); the formula has the advantages that the medicine and the food are obtained simultaneously, the traditional Chinese medicine compatibility degree of the traditional Chinese medicine theory is followed, and the pharmacological analysis of the modern traditional Chinese medicine and the related theory and clinical achievement of the modern medicine are combined; the ingredients have mild drug property, sweet and palatable taste, clear and balanced nourishment and consideration of both principal and secondary aspects, and the formula adopts the raw materials which are homologous with medicine and food, has no addition, is safe and nontoxic, and accords with the essential attribute of food therapy; the process adopts superfine pulverizing process, so that the active ingredients can be quickly absorbed, and the drug effect and bioavailability can be obviously improved.
Detailed Description
The following examples are intended to illustrate the invention, but are not intended to limit the scope of the invention. It is intended that all modifications or alterations to the methods, procedures or conditions of the present invention be made without departing from the spirit and substance of the invention.
Example 1
Raw materials: 250g of white hyacinth bean, 250g of Chinese yam, 250g of lotus seed, 250g of malt, 250g of coix seed, 250g of gordon euryale seed, 250g of tuckahoe and 250g of taro.
The preparation method comprises the following steps:
firstly, selecting, cleaning, slicing and drying, weighing the raw materials of white hyacinth bean, Chinese yam, lotus seed, malt, coix seed, gordon euryale seed, tuckahoe and taro according to the mass, drying at 40 ℃, carrying out coarse crushing, and sieving by a 24-mesh sieve to obtain mixture coarse powder; drying at low temperature (-20 deg.C), micronizing at ultralow temperature (-35 deg.C), sieving to obtain micropowder of no more than 70 μm, mixing, sterilizing, and packaging to obtain superfine powder.
Example 2
Raw materials: 150g of white hyacinth bean, 150g of Chinese yam, 150g of lotus seed, 150g of malt, 150g of coix seed, 150g of gordon euryale seed, 150g of tuckahoe and 100g of taro.
The preparation method comprises the following steps:
firstly, selecting, cleaning, slicing and drying, weighing the raw materials of white hyacinth bean, Chinese yam, lotus seed, malt, coix seed, gordon euryale seed, tuckahoe and taro according to the mass, drying at 40 ℃, carrying out coarse crushing, and sieving with a sieve of 65 meshes to obtain mixture coarse powder; drying at low temperature (-10 deg.C), micronizing at ultralow temperature (-30 deg.C), sieving to obtain micropowder no greater than 70 μm, mixing, sterilizing, and packaging to obtain superfine powder.
Example 3
Raw materials: 300g of white hyacinth bean, 300g of Chinese yam, 300g of lotus seed, 300g of malt, 300g of coix seed, 300g of gordon euryale seed, 300g of poria cocos and 250g of taro.
The preparation method comprises the following steps:
firstly, selecting, cleaning, slicing and drying, weighing the raw materials of white hyacinth bean, Chinese yam, lotus seed, malt, coix seed, gordon euryale seed, tuckahoe and taro according to the mass, drying at 35 ℃, carrying out coarse crushing, and sieving by a 24-mesh sieve to obtain mixture coarse powder; drying at low temperature (-10 deg.C), micronizing at ultralow temperature (-30 deg.C), sieving to obtain micropowder of no more than 70 μm, mixing, sterilizing, and packaging to obtain superfine powder.
Example 4
Raw materials: 200g of white hyacinth bean, 200g of Chinese yam, 200g of lotus seed, 200g of malt, 200g of coix seed, 200g of gordon euryale seed, 200g of poria cocos and 150g of taro.
The preparation method comprises the following steps: the preparation method comprises the following steps:
firstly, selecting, cleaning, slicing and drying, weighing the raw materials of white hyacinth bean, Chinese yam, lotus seed, malt, coix seed, gordon euryale seed, poria cocos and taro according to the mass, drying at 50 ℃, carrying out coarse crushing, and sieving by a sieve of 65 meshes to obtain mixture coarse powder; drying at low temperature (-20 deg.C), micronizing at ultralow temperature (-35 deg.C), sieving to obtain micropowder no greater than 70 μm, mixing, sterilizing, and packaging to obtain superfine powder.
Blank control group 1
Raw materials: 500g of starch.
The preparation method comprises the following steps: prepared as described in example 1.
The quality of the ultrafine blending powders prepared in examples 1 to 4 was checked, and the detection results are shown in table 1:
TABLE 1 quality test results of ultrafine powder
| Item | Example 1 | Example 2 | Example 3 | Example 4 |
| Moisture (%) | 5.4 | 5.0 | 5.2 | 5.1 |
| Lead (mg/kg) | Undetected | Not detected out | Not detected out | Not detected out |
| Arsenic (mg/kg) | Not detected out | Not detected out | Not detected out | Undetected |
| Mercury (mg/kg) | Not detected out | Not detected out | Not detected out | Undetected |
| Total number of colonies (cfu/g) | <10 | <10 | <10 | <10 |
| Coliform group (cfu/g) | Not detected out | Not detected out | Not detected out | Not detected out |
| Mold (cfu/g) | Not detected out | Not detected out | Not detected out | Not detected out |
The following describes the application effect of the product:
clinical observation of superfine brewing powder for regulating spleen and stomach to treat chronic gastritis with syndrome of dampness-heat in spleen and stomach
1. Data and method
1.1 clinical data
120 patients with gastritis and damp-heat syndrome of spleen and stomach are selected, and the selected patients are respectively included into 80 cases of treatment groups and 40 cases of control groups according to the diagnosis sequence by adopting a random digital table. The general data of sex, age, course of disease, etc. of two groups of patients have no obvious difference, P is more than 0.05, and the statistical significance is avoided, and the groups have comparability.
1.2 diagnostic criteria
Western diagnostic criteria: the clinical symptoms of chronic gastritis have no specificity, the common symptoms comprise epigastric pain, abdominal distension, early satiety, anorexia, heart burn, acid regurgitation, hiccup, eructation and the like, and basic symptoms such as congestion and edema of gastric mucosa, erythema (punctate, sheet and strip), bleeding points (spots) and/or erosion (flat or bulge), exudation and the like can be seen under a gastroscope mainly through the lower gastroscope expression and the lower endoscope pathological examination; there are also signs of bleeding, gross folds or bile reflux. The clinical study is mainly used for determining the clinical condition of a patient according to the clinical symptoms of the patient and the condition of the patient under a gastroscope which meets the diagnostic standard of the chronic superficial gastritis.
The traditional Chinese medicine diagnosis standard is as follows: according to the study and observation of patients with chronic superficial gastritis who are patients with spleen and stomach damp-heat syndrome based on traditional Chinese medicine differentiation, referring to the guiding principle (trial) of new traditional Chinese medicine clinical research and the consensus opinion of combined traditional Chinese and western medicine diagnosis and treatment of chronic gastritis, the clinical symptoms mainly comprise abdominal fullness and distention or pain, and the secondary symptoms comprise poor appetite or no appetite, belching and acid regurgitation, heavy and sleepy body, nausea and vomiting, pale and dull taste, red tongue, white and greasy or yellow greasy tongue coating and slippery or rapid pulse. The tongue pulse can be diagnosed when the tongue pulse basically conforms to the main symptoms 2 or the main symptoms 1 plus the secondary symptoms 2 or more.
1.3 inclusion criteria
The patient who accords with the diagnosis of the western medicine, namely the chronic superficial gastritis and the dialectical typing standard of the traditional Chinese medicine is 18-65 years old, and the patient agrees with the information and voluntarily joins the clinical research.
1.4 exclusion criteria
Patients who do not meet inclusion criteria; patients with peptic ulcer, peptic tumor, and pyloric obstruction; patients with severe center of gravity, lung, brain disease and mental illness; pregnant and lactating women.
1.5 methods of treatment
Example 1 was used for treatment group 1, example 2 was used for treatment group 2, example 3 was used for treatment group 3, and example 4 was used for treatment group 4, 2 times/d, 30 g/time, and 4 weeks was used as a treatment course. The control group 2 adopts western medicine therapy, and the administration comprises taking magnesium aluminum carbonate tablet 1 g/time, 3 times/day, and domperidone 50 mg/time, 3 times/day; a treatment course is 4 weeks. The treatment effect of each group is compared after 1 treatment course is finished.
1.6 evaluation method of therapeutic Effect
The curative effect is judged according to the clinical curative effect standard set by the consensus opinion of the chronic gastritis and the opinion of the traditional Chinese medicine and the traditional Chinese medicine for treating the chronic gastritis. Each case was subjected to the integration of the symptoms before and after treatment, and then the integration was counted, and the degree of change in the integral of the symptoms after treatment and after treatment was compared with that before treatment, and the efficacy index (integration before treatment-integration after treatment)/integration before treatment × 100%) was obtained. The observed clinical symptoms, physical signs and the change condition of the curative effect index are calculated according to the following treatment effect evaluation standard, and the curative effect is evaluated.
And (3) healing: the clinical symptoms completely or basically disappear, the change of the active inflammation of the gastric mucosa under the gastroscope disappears, the chronic inflammation is improved to be mild, and the curative effect index is more than or equal to 95 percent;
the effect is shown: the symptoms are obviously improved, the acute inflammation change of gastric mucosa under gastroscope basically disappears, the chronic inflammation is improved, and the curative effect index is more than or equal to 70 percent and less than 95 percent;
the method has the following advantages: the symptoms are obviously improved, the lesion area of the gastric mucosa under the gastroscope is reduced by more than 1/2, the inflammation is improved, and the curative effect index is more than or equal to 30 percent and less than 70 percent;
and (4) invalidation: the general symptoms and gastroscopy are not obviously improved and even have aggravation signs, and the curative effect index is less than 30 percent.
The total effective rate (%) - (cure + significant effect + effective) cases/group number × 100%.
1.7 statistical analysis
Analyzing and processing each data by adopting statistical software SPSS 22.0, and expressing the measurement data by adopting the mean value plus or minus standard deviation of a sample; the comparison among groups adopts t test; the comparison of the counting data and the inter-group rate adopts non-parameter test, and the difference is that P is less than 0.05, which has statistical significance.
1.8 results
The results are shown in Table 2.
TABLE 2 comparison of clinical effects of the groups
The difference was statistically significant (P < 0.05).
1.9 conclusion
The ultrafine brewing powder for regulating spleen and stomach provided by the invention has a remarkable curative effect on treatment of chronic gastritis and spleen and stomach damp-heat syndrome, and no relapse of patients in a treatment group is observed in a follow-up process; in addition, no adverse reaction and toxic or side effect are found in the process of verifying the curative effect, and the preparation is worthy of clinical popularization and application.
The previous description of the various embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. The superfine mixing powder for regulating spleen and stomach is characterized by being prepared from the following raw materials: white hyacinth bean, Chinese yam, lotus seed, malt, coix seed, gordon euryale seed, tuckahoe and taro.
2. The ultrafine powder for regulating spleen and stomach according to claim 1, wherein the weight parts of the components are as follows: 15-30 parts of white hyacinth bean, 15-30 parts of Chinese yam, 15-30 parts of lotus seed, 15-30 parts of malt, 15-30 parts of coix seed, 15-30 parts of gordon euryale seed, 15-30 parts of poria cocos and 10-30 parts of taro.
3. The ultrafine powder for regulating the spleen and stomach according to claim 2, wherein: 20-25 parts of white hyacinth bean, 20-25 parts of Chinese yam, 20-25 parts of lotus seed, 20-25 parts of malt, 20-25 parts of coix seed, 20-25 parts of gordon euryale seed, 20-25 parts of poria cocos and 15-25 parts of taro.
4. The superfine brewing powder for regulating spleen and stomach according to any one of claims 1 to 3, wherein the superfine brewing powder is a wall-broken powder, and the particle size of the wall-broken powder is not more than 70 μm.
5. The ultrafine blending powder for regulating spleen and stomach according to claim 4, wherein the particle size of the wall-broken powder is 25-55 μm.
6. A preparation method of the ultrafine powder for regulating spleen and stomach according to claims 1 to 5, which is characterized by comprising the following steps:
step 1, coarsely crushing the raw materials, and sieving to obtain coarse powder of a mixture;
step 2, drying the coarse powder of the mixture obtained in the step 3 at a low temperature, and carrying out ultra-low temperature superfine grinding to obtain superfine powder of the mixture;
and 3, mixing the mixture obtained in the step 4 with superfine powder, and sieving to obtain the wall-broken powder.
7. The method for preparing ultrafine powder for regulating spleen and stomach according to claim 6, wherein the raw materials are pulverized and then mixed.
8. The method for preparing the ultrafine powder for regulating the spleen and stomach according to claim 6, wherein the raw materials are mixed and then pulverized.
9. A drug for regulating the spleen and stomach, which comprises the ultrafine powder for regulating the spleen and stomach according to claims 1 to 8.
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