CN115023227A - 用于治疗癌症的PD-1拮抗剂、VEGFR/FGFR/RET酪氨酸激酶抑制剂和CBP/β-联蛋白抑制剂的组合 - Google Patents
用于治疗癌症的PD-1拮抗剂、VEGFR/FGFR/RET酪氨酸激酶抑制剂和CBP/β-联蛋白抑制剂的组合 Download PDFInfo
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Abstract
Description
原始残基 | 保守取代 |
Ala (A) | Gly;Ser |
Arg (R) | Lys;His |
Asn (N) | Gln;His |
Asp (D) | Glu;Asn |
Cys (C) | Ser;Ala |
Gln (Q) | Asn |
Glu (E) | Asp;Gln |
Gly (G) | Ala |
His (H) | Asn;Gln |
Ile (I) | Leu;Val |
Leu (L) | Ile;Val |
Lys (K) | Arg;His |
Met (M) | Leu;Ile;Tyr |
Phe (F) | Tyr;Met;Leu |
Pro (P) | Ala |
Ser (S) | Thr |
Thr (T) | Ser |
Trp (W) | Tyr;Phe |
Tyr (Y) | Trp;Phe |
Val (V) | Ile;Leu |
第1天 | 第4天 | 第8天 | 第11天 | 第15天 | 第18天 | 第22天 | 第25天 | 第29天 | |
对照组 | 62 | 93 | 152 | 297 | 419 | 618 | 822 | 1101 | 1160 |
乐伐替尼组 | 62 | 82 | 102 | 134 | 152 | 175 | 162 | 166 | 151 |
抗PD-1抗体组 | 62 | 86 | 124 | 165 | 222 | 274 | 347 | 414 | 482 |
E7386组 | 62 | 93 | 148 | 210 | 301 | 408 | 588 | 723 | 923 |
乐伐替尼+抗PD-1抗体双组合组 | 62 | 73 | 78 | 92 | 86 | 72 | 58 | 49 | 38 |
E7386+乐伐替尼双组合组 | 62 | 70 | 74 | 83 | 84 | 83 | 78 | 71 | 68 |
三重组合组 | 62 | 70 | 61 | 55 | 31 | 21 | 12 | 7 | 4 |
Claims (29)
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US201962927334P | 2019-10-29 | 2019-10-29 | |
US201962927576P | 2019-10-29 | 2019-10-29 | |
US62/927334 | 2019-10-29 | ||
US62/927576 | 2019-10-29 | ||
PCT/US2020/057650 WO2021086909A1 (en) | 2019-10-29 | 2020-10-28 | Combination of a pd-1 antagonist, a vegfr/fgfr/ret tyrosine kinase inhibitor and a cbp/beta-catenin inhibitor for treating cancer |
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Publication Number | Publication Date |
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CN115023227A true CN115023227A (zh) | 2022-09-06 |
CN115023227B CN115023227B (zh) | 2024-06-18 |
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CN202080075657.8A Active CN115023227B (zh) | 2019-10-29 | 2020-10-28 | 用于治疗癌症的PD-1拮抗剂、VEGFR/FGFR/RET酪氨酸激酶抑制剂和CBP/β-联蛋白抑制剂的组合 |
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US (1) | US20220409724A1 (zh) |
EP (1) | EP4051278A1 (zh) |
JP (1) | JP2023500575A (zh) |
KR (1) | KR20220092540A (zh) |
CN (1) | CN115023227B (zh) |
AU (1) | AU2020374883A1 (zh) |
BR (1) | BR112022007971A8 (zh) |
CA (1) | CA3155672A1 (zh) |
MX (1) | MX2022005056A (zh) |
TW (1) | TW202137984A (zh) |
WO (1) | WO2021086909A1 (zh) |
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CA2988707C (en) | 2015-06-16 | 2023-10-10 | Eisai R&D Management Co., Ltd. | Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer |
AU2022342537A1 (en) * | 2021-09-08 | 2024-02-15 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating solid tumors |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2016141218A1 (en) * | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
WO2018147275A1 (ja) * | 2017-02-08 | 2018-08-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
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US20040072831A1 (en) | 2001-10-12 | 2004-04-15 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US7576084B2 (en) | 2001-10-12 | 2009-08-18 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
IL149820A0 (en) | 2002-05-23 | 2002-11-10 | Curetech Ltd | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency |
EP2206517B1 (en) | 2002-07-03 | 2023-08-02 | Ono Pharmaceutical Co., Ltd. | Immunopotentiating compositions comprising anti-PD-L1 antibodies |
BR0316880A (pt) | 2002-12-23 | 2005-10-25 | Wyeth Corp | Anticorpos contra pd-1 e usos dos mesmos |
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EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
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WO2016141218A1 (en) * | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
WO2018147275A1 (ja) * | 2017-02-08 | 2018-08-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
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CN115023227B (zh) | 2024-06-18 |
BR112022007971A8 (pt) | 2023-02-07 |
US20220409724A1 (en) | 2022-12-29 |
EP4051278A1 (en) | 2022-09-07 |
CA3155672A1 (en) | 2021-05-06 |
TW202137984A (zh) | 2021-10-16 |
AU2020374883A1 (en) | 2022-05-26 |
BR112022007971A2 (pt) | 2022-07-12 |
WO2021086909A1 (en) | 2021-05-06 |
KR20220092540A (ko) | 2022-07-01 |
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MX2022005056A (es) | 2022-05-18 |
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