CN115003800A - 治疗血管疾病的方法 - Google Patents

治疗血管疾病的方法 Download PDF

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CN115003800A
CN115003800A CN202080075675.6A CN202080075675A CN115003800A CN 115003800 A CN115003800 A CN 115003800A CN 202080075675 A CN202080075675 A CN 202080075675A CN 115003800 A CN115003800 A CN 115003800A
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樱井渚
M·弥罗特索
N·普拉萨恩
A·辛格
R·兰沙
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Astellas Institute for Regenerative Medicine
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CN202080075675.6A 2019-08-28 2020-08-27 治疗血管疾病的方法 Pending CN115003800A (zh)

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US201962892712P 2019-08-28 2019-08-28
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PCT/US2020/048080 WO2021041592A1 (en) 2019-08-28 2020-08-27 Methods of treating vascular diseases

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116832051A (zh) * 2023-07-08 2023-10-03 首都医科大学 新型抗氧化抗炎和促脂质代谢协同纳米给药系统

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102411018B1 (ko) 2015-08-18 2022-06-20 아스텔라스 인스티튜트 포 리제너러티브 메디슨 임상 제제
US20230027007A1 (en) * 2021-07-02 2023-01-26 Regeneron Pharmaceuticals, Inc. Treatment of Hypertension With Solute Carrier Family 9 Isoform A3 Regulatory Factor 2 (SLC9A3R2) Inhibitors

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101534747A (zh) * 2006-07-10 2009-09-16 哥伦比亚大学 从组织祖细胞和血管祖细胞从头形成和再生血管化组织
US20130171110A1 (en) * 2011-12-05 2013-07-04 DeWitt Ross & Stevens S.C. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
CN103221058A (zh) * 2010-08-27 2013-07-24 迈阿密大学 用于心脏修复的骨髓衍生cd271前体细胞
CN105101979A (zh) * 2012-12-21 2015-11-25 奥卡塔治疗公司 由多能干细胞制备血小板的方法及其组合物
CN105209609A (zh) * 2013-03-13 2015-12-30 威斯康星校友研究基金会 用于限定条件下的人多潜能干细胞的血内皮分化的方法和材料
CN106434527A (zh) * 2006-04-14 2017-02-22 安斯泰来再生医药协会 血管瘤集落形成细胞
CN107429230A (zh) * 2015-01-26 2017-12-01 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
US20180142207A1 (en) * 2016-11-18 2018-05-24 Wisconsin Alumni Research Foundation Induction of arterial-type of hemogenic endothelium (ahe) and enhancement of t cell production from pscs through overexpression of ets factors or modulating mapk/erk signalling pathways
CN108601356A (zh) * 2015-12-03 2018-09-28 布里格姆妇女医院 生成功能性造血干细胞的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070083A2 (en) * 2002-02-15 2003-08-28 Cornell Research Foundation, Inc. Endothelial precursor cells for enhancing and restoring vascular function
BRPI0912201A2 (pt) 2008-05-06 2019-09-24 Advanced Cell Tech Inc células formadoras de colônias de hemangios e células de hemangio não enxertantes
PL2785359T3 (pl) 2011-11-30 2018-12-31 Astellas Institute For Regenerative Medicine Mezenchymalne komórki zrębowe i związane z nimi zastosowania
JP6746313B2 (ja) * 2012-08-01 2020-08-26 ユナイテッド セラピューティクス コーポレイション プロスタサイクリン処理された内皮前駆細胞による肺動脈性高血圧症の処置
CA2930304A1 (en) * 2013-11-13 2015-05-21 Cornell University Post-natal hematopoeitic endothelial cells and their isolation and use
KR102411018B1 (ko) 2015-08-18 2022-06-20 아스텔라스 인스티튜트 포 리제너러티브 메디슨 임상 제제

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106434527A (zh) * 2006-04-14 2017-02-22 安斯泰来再生医药协会 血管瘤集落形成细胞
CN101534747A (zh) * 2006-07-10 2009-09-16 哥伦比亚大学 从组织祖细胞和血管祖细胞从头形成和再生血管化组织
CN103221058A (zh) * 2010-08-27 2013-07-24 迈阿密大学 用于心脏修复的骨髓衍生cd271前体细胞
US20130171110A1 (en) * 2011-12-05 2013-07-04 DeWitt Ross & Stevens S.C. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
CN105101979A (zh) * 2012-12-21 2015-11-25 奥卡塔治疗公司 由多能干细胞制备血小板的方法及其组合物
CN105209609A (zh) * 2013-03-13 2015-12-30 威斯康星校友研究基金会 用于限定条件下的人多潜能干细胞的血内皮分化的方法和材料
CN107429230A (zh) * 2015-01-26 2017-12-01 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
CN108601356A (zh) * 2015-12-03 2018-09-28 布里格姆妇女医院 生成功能性造血干细胞的方法
US20190177695A1 (en) * 2015-12-03 2019-06-13 The Brigham And Women's Hospital, Inc. Methods for generating functional hematopoietic stem cells
US20180142207A1 (en) * 2016-11-18 2018-05-24 Wisconsin Alumni Research Foundation Induction of arterial-type of hemogenic endothelium (ahe) and enhancement of t cell production from pscs through overexpression of ets factors or modulating mapk/erk signalling pathways

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
DUONG H 等: "Pro-angiogenic hematopoietic progenitor cells and endothelial colony-forming cells in pathological angiogenesis of bronchial and pulmonary circulation", 《ANGIOGENESIS》, vol. 14, no. 4, 28 July 2011 (2011-07-28), pages 411 - 422, XP019976523, DOI: 10.1007/s10456-011-9228-y *
JANKOWSKA-STEIFER E 等: "Vasculogenic and hematopoietic cellular progenitors are scattered within the prenatal mouse heart", 《HISTOCHEM CELL BIOL》, vol. 143, no. 2, 9 September 2014 (2014-09-09), pages 153 - 169, XP035429548, DOI: 10.1007/s00418-014-1269-z *
LOISEL F 等: "Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy?", 《PULM CIRC》, vol. 8, no. 2, 26 February 2018 (2018-02-26), pages 1 - 17, XP055736793, DOI: 10.1177/2045893218755979 *
SCOTT, ELIZABETH STEPHANIE: "Derivation of vascular endothelium from human embryonic stem cells: the roles of microRNAs in endothelial differentiation and commitment", 《UNIVERSITY OF GLASGOW博士论文》, 10 February 2016 (2016-02-10) *
UENISHI G 等: "NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells", 《NAT COMMUN》, vol. 9, no. 2, 8 May 2018 (2018-05-08), pages 1 - 14 *
WANG L 等: "Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow", 《BIOMICROFLUIDICS》, vol. 10, no. 1, 13 January 2016 (2016-01-13), pages 1 - 13, XP055736650, DOI: 10.1063/1.4940041 *
刘婷 等: "低氧通过上调Wnt5a促进人胚胎干细胞向生血内皮细胞分化", 《中国科学:生命科学》, vol. 43, no. 10, 20 October 2013 (2013-10-20), pages 877 - 885 *
刘治全 等主编: "《高血压病诊断治疗学 第2版》", vol. 2006, 31 July 2006, 中国协和医科大学出版社, pages: 192 *
单威: "三维自组装多肽生物材料介导的小鼠多能干细胞向造血细胞分化的作用及机制研究", 《中国博士学位论文全文数据库(电子期刊)医药卫生科技辑》, no. 8, 15 August 2018 (2018-08-15), pages 080 - 6 *
徐学受 主编: "《临床肺科手册》", vol. 2008, 31 March 2008, 上海科学技术出版社, pages: 558 - 559 *
朱晓东 主编: "《中华医学百科全书 临床医学 心脏外科学》", vol. 2018, 31 December 2018, 中国协和医科大学出版社, pages: 109 *
沈利亚 等主编: "《实用临床老年病学》", vol. 2014, 30 June 2014, 湖南科学技术出版社, pages: 58 - 59 *
赵月: "内皮微环境NOTCH信号通路促进人多能干细胞造血分化的实验研究", 《中国优秀硕士学位论文全文数据库(电子期刊)医药卫生科技辑》, no. 1, 15 January 2019 (2019-01-15), pages 059 - 72 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116832051A (zh) * 2023-07-08 2023-10-03 首都医科大学 新型抗氧化抗炎和促脂质代谢协同纳米给药系统
CN116832051B (zh) * 2023-07-08 2024-02-09 首都医科大学 抗氧化抗炎和促脂质代谢协同纳米给药系统

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WO2021041592A9 (en) 2021-06-24
AU2020337929B2 (en) 2026-07-16
US20220280572A1 (en) 2022-09-08
JP2022547832A (ja) 2022-11-16
WO2021041592A1 (en) 2021-03-04
AU2020337929A1 (en) 2022-03-24
JP7876440B2 (ja) 2026-06-19
CA3151637A1 (en) 2021-03-04
KR20220054359A (ko) 2022-05-02
EP4022042A1 (en) 2022-07-06
WO2021041592A8 (en) 2021-04-01
IL290892A (en) 2022-04-01

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