CN115003387A - 用于活化和扩增肿瘤浸润淋巴细胞的方法 - Google Patents

用于活化和扩增肿瘤浸润淋巴细胞的方法 Download PDF

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CN115003387A
CN115003387A CN202080093941.8A CN202080093941A CN115003387A CN 115003387 A CN115003387 A CN 115003387A CN 202080093941 A CN202080093941 A CN 202080093941A CN 115003387 A CN115003387 A CN 115003387A
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til
population
agonist
days
expansion
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迈卡·本森
尼古拉斯·约翰·科莱蒂
诺亚·雅各布·图博
迈克尔·施拉巴赫
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Ksq Treatment Co
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Ksq Treatment Co
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CN202080093941.8A 2019-11-25 2020-11-24 用于活化和扩增肿瘤浸润淋巴细胞的方法 Pending CN115003387A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962940035P 2019-11-25 2019-11-25
US62/940,035 2019-11-25
US202063081539P 2020-09-22 2020-09-22
US63/081,539 2020-09-22
PCT/US2020/062094 WO2021108455A1 (en) 2019-11-25 2020-11-24 Methods for activation and expansion of tumor infiltrating lymphocytes

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CN115003387A true CN115003387A (zh) 2022-09-02

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US (1) US20240376428A1 (https=)
EP (1) EP4065233A4 (https=)
JP (2) JP2023502780A (https=)
KR (1) KR20220119038A (https=)
CN (1) CN115003387A (https=)
AU (1) AU2020392094A1 (https=)
CA (1) CA3162272A1 (https=)
WO (1) WO2021108455A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025055493A1 (zh) * 2023-09-15 2025-03-20 毕诺济(上海)生物技术有限公司 基因编辑的肿瘤浸润淋巴细胞及其在免疫细胞治疗中的应用
WO2025092690A1 (zh) * 2023-10-30 2025-05-08 苏州沙砾生物科技有限公司 一种修饰的细胞及其用途

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AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
US12365871B2 (en) 2020-04-28 2025-07-22 Lyell Immunopharma, Inc. Methods for culturing cells
WO2021252804A1 (en) 2020-06-12 2021-12-16 Nkarta, Inc. Genetically modified natural killer cells for cd70-directed cancer immunotherapy
CN114901805B (zh) 2020-11-19 2023-07-25 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的培养方法及其用途
CN117616115A (zh) * 2021-08-03 2024-02-27 苏州沙砾生物科技有限公司 一种修饰的肿瘤浸润淋巴细胞及其用途
WO2023039410A1 (en) * 2021-09-08 2023-03-16 KSQ Therapeutics, Inc. Lymphocyte potency assay
CN118414422A (zh) * 2021-12-30 2024-07-30 苏州沙砾生物科技有限公司 一种修饰的肿瘤浸润淋巴细胞及其用途
WO2023138598A1 (zh) * 2022-01-19 2023-07-27 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞在疾病治疗中的用途
EP4471128A4 (en) * 2022-01-29 2026-03-04 Suzhou Grit Biotechnology Co Ltd Modified tumor infiltrating lymphocyte and use thereof
CA3254363A1 (en) * 2022-03-07 2023-09-14 Nkarta, Inc. Multiplex gene-edited cells for CD70-led cancer immunotherapy

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US20140087462A1 (en) * 2012-09-25 2014-03-27 Miltenyi Biotec Gmbh Method for polyclonal stimulation of t cells by flexible nanomatrices
US20160068811A1 (en) * 2014-09-04 2016-03-10 Stemcell Technologies Inc. Soluble Antibody Complexes For T Cell or NK Cell Activation and Expansion
US20160185861A1 (en) * 2014-12-29 2016-06-30 Felipe Bedoya Methods of making chimeric antigen receptor -expressing cells
CN108473957A (zh) * 2015-04-17 2018-08-31 诺华股份有限公司 改善嵌合抗原受体表达细胞的功效和扩增的方法
US20180250338A1 (en) * 2015-11-18 2018-09-06 Duke University Tumor infiltrating lymphocytes for treatment of cancer
WO2019178421A1 (en) * 2018-03-15 2019-09-19 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy

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WO2010098429A1 (ja) * 2009-02-27 2010-09-02 国立大学法人大阪大学 免疫アジュバント組成物、及びその利用
WO2015188228A1 (en) * 2014-06-10 2015-12-17 Monash University Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer
TWI788307B (zh) * 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
US11261428B2 (en) * 2018-03-15 2022-03-01 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy
US20200224161A1 (en) * 2017-05-10 2020-07-16 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
CN108753718A (zh) * 2018-06-20 2018-11-06 淮安诺康生物科技有限公司 肿瘤浸润淋巴细胞til的体外扩增方法

Patent Citations (6)

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US20140087462A1 (en) * 2012-09-25 2014-03-27 Miltenyi Biotec Gmbh Method for polyclonal stimulation of t cells by flexible nanomatrices
US20160068811A1 (en) * 2014-09-04 2016-03-10 Stemcell Technologies Inc. Soluble Antibody Complexes For T Cell or NK Cell Activation and Expansion
US20160185861A1 (en) * 2014-12-29 2016-06-30 Felipe Bedoya Methods of making chimeric antigen receptor -expressing cells
CN108473957A (zh) * 2015-04-17 2018-08-31 诺华股份有限公司 改善嵌合抗原受体表达细胞的功效和扩增的方法
US20180250338A1 (en) * 2015-11-18 2018-09-06 Duke University Tumor infiltrating lymphocytes for treatment of cancer
WO2019178421A1 (en) * 2018-03-15 2019-09-19 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025055493A1 (zh) * 2023-09-15 2025-03-20 毕诺济(上海)生物技术有限公司 基因编辑的肿瘤浸润淋巴细胞及其在免疫细胞治疗中的应用
WO2025092690A1 (zh) * 2023-10-30 2025-05-08 苏州沙砾生物科技有限公司 一种修饰的细胞及其用途

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CA3162272A1 (en) 2021-06-03
AU2020392094A1 (en) 2022-06-23
WO2021108455A1 (en) 2021-06-03
US20240376428A1 (en) 2024-11-14
EP4065233A1 (en) 2022-10-05
EP4065233A4 (en) 2024-07-10
JP2025159098A (ja) 2025-10-17
KR20220119038A (ko) 2022-08-26
JP2023502780A (ja) 2023-01-25

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