KR20140072035A - 상피세포 성장 인자 수용체 유전자에서의 돌연변이 - Google Patents
상피세포 성장 인자 수용체 유전자에서의 돌연변이 Download PDFInfo
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Abstract
본 발명은 세투시마브(cetuximab)를 포함하는 치료 요법에 대한 저항 및 패니투무마브(panitumumab)를 포함하는 치료 요법에 대한 민감성과 매우 상관이 있는 아미노산의 변경을 유도하는, 상피세포 성장 인자 수용체 유전자에서 새롭게 식별된 돌연변이에 관한 것이다. 본 발명은 세투시마브 및/또는 패니투무마브를 포함하는 치료요법에 대한 대상의 반응을 예측하기 위한 키트는 물론, 그러한 돌연변이를 검출하기 위한 펩티드 서열, 프라이머 및 탐침을 포함한다. 특히, 본 발명은 전이성 결장암 및 두경부암에 적용가능한 치료 요법에서 유용하다.
Description
본 발명은 단일클론 항체 치료에 대한 반응을 결정하기 위한 마커로서, 인간 상피세포 성장 인자 수용체 유전자의 돌연변이에 관한 것이다.
상피세포 성장 인자 수용체 유전자(EGFR)는 4개의 밀접하게 관련된 수용체 티로신 키나아제: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) 및 Her 4 (ErbB-4)를 포함하는, 수용체의 상피세포 성장 인자 패밀리(ErbB 패밀리)에 속하는 트랜스멤브레인 티로신-키나아제 수용체이다. 리간드 결합 시에, EGFR은 아포프토시스, 세포 성장, 혈관형성 및 전이와 같은 핵심적인 종양형성 이벤트를 조절하는, 세포내 신호 경로, 주로 RAS-RAF-MEK-ERK 캐스케이드 및 PI3KAkt 경로를 활성화한다. EGFR의 이상 활성화 또는 과발현은 여러 유형의 암에서 보고되었다(즉, 멘델손 제이, 바셀가 제이 등, "암에서 표적으로 하는 상피세포 성장 인자 수용체". 종양학 세미나-2006, 33권, 369-38쪽). EGFR 유전자에서 돌연변이는 폐암에서 설명되었다. 그러한 돌연변이의 사례가 예를 들어, 린치 티제이 등, "제피티니브에 대한 비소세포 폐암의 상피세포 성장 인자 수용체 기저 반응성에서 돌연변이를 활성화", 뉴 잉글랜드 의학저널-2004, 350권, 2129-2139쪽의 문헌에서; 또는 파에즈 제이지 등, "폐암에서 EGFR 돌연변이: 제피티니브 치료에 대한 임상 반응과의 상관관계", 사이 언스-2004, 304권, 1497-500쪽에서; 또는 파오 더블유 등, "EGF 수용체 유전자 돌연변이는 "흡연 미경험자"로부터의 폐암에서 공통적이고 제피티니브 및 에를로티니브에 대한 종양의 민감성과 연관된다", 미국국립과학원회보-2004, 101권, 13306-13311쪽에 개시된다).
전이성 결장암(mCRC)은 세계 서방 국가에서 암으로 인한 사망의 제 2의 주요 원인이다.
EGFR에 대항하는 단일 클론 항체(moAb), 예를 들어, 세투시마브 및 패니투무마브에 기반한 치료는 mCRC를 갖는 환자에게 현저한 생존 혜택을 제공하고 현재 이들 환자에 대한 치료 요법의 표준 성분이다, 즉, 단독으로 또는 다른 항종양성 약물(들)과 조합해서. 이들 moAb 중 하나, 세투시마브(얼비툭스(Erbitux))는 백금 기반 화학요법과 조합해서, 두경부암으로도 명명된, 두경부의 편평상피암을 갖는 환자의 치료를 위해 역시 처방된다.
moAb는 암 세포 상에 발현된 외부 항원에 결합한다. 일단 결합되면, 암 세포는 환자의 면역 시스템에 의해 파괴된 것으로 표시된다. 암 세포를 표적으로 하는 것에 더해서, moAb는 종양 성장에 필요한 다른 세포 유형 및 분자 상에 작용하도록 설계될 수 있다. 예를 들어, 항체는 성장 인자를 중화시키고 그로써 종양 팽창을 억제시킬 수 있다. 대개의 임의의 세포외/세포 표면 표적(암 세포와 같음)에 특정한 moAb를 생성하는 것이 가능하다. 요약하면, moAb는 악성 종양 세포를 파괴하고 특정 세포 수용체를 차단하는 것에 의해 종양 성장을 방지하도록 사용될 수 있다. 치료적 moAb 세투시마브 및 패니투무마브는 EGFR에 결합하고 EGFR에 의해 유도되는 세포내 신호 경로(즉, RAS-RAF-MEK-ERK 캐스케이드 및 PI3K-akt 경로)의 활성화를 방지한다.
불행히도, mCRC를 갖는 모든 환자가 moAb를 포함하는 치료 요법에 반응하는 것은 아니다. 그러한 치료에 대해 mCRC를 갖는 환자의 반응 부족은 1차적일 수 있다, 즉, 항-EGFR moAb 치료의 시작 이후; 1차 저항으로 공지됨. 게다가, 항-EGFR moAb에 대해 처음에 반응하는 모든 mCRC 환자는 변함없이 2차 저항을 전개한다, 즉, 항-EGFR moAb에 대해 얻어진 저항. 두 경우 모두에서, 결과는 치료 실패이다. mCRC 환자에서 그러한 치료 저항의 획득에 기여하는 기전은 여전히 충분히 알려지지 않고 있다. 항-EGFR moAb 치료(1차 또는 2차)에 대한 동일한 저항이 두경부암을 갖는 환자에서 관찰된다.
KRAS(V-Ki-ras2 커스텐 쥐 육종 바이러스성 종양유전자 동족체로도 공지됨)는 EGFR 하류 이펙터이고, 항-EGFR moAb에 대한 1차 저항의 마커이다. KRAS는 mCRC환자의 치료의 최적화에 대해 상당한 영향력을 가진다. 결장 종양의 40퍼센트가 KRAS 유전자에서 돌연변이를 품고 있고 이들 환자는 항-EGFR moAb로부터 혜택을 받지 못한다. 현재 임상 실시에서 항-EGFR moAb 치료에 대해 고려되는 모든 mCRC 환자는 KRAS 테스팅을 거쳐야만 하고, KRAS 돌연변이가 검출된다면 환자는 세투시마브 또는 패니투무마브 치료로부터 배제되어야만 한다.
그럼에도, 야생형 KRAS 종양을 갖는 mCRC 환자의 일부는 여전히 항-EGFR moAb로부터 혜택을 받지 못한다. 아마도 등, "야생형 KRAS는 전이성 결장암을 갖는 환자에서 패니투무마브 효험에 대해 요구됨", 미국 임상종양학회지-2008, 28권, 1626-1634쪽으로부터 유도되는 바와 같이, 야생형 KRAS 대상에서 항-EGFR moAb에 대한 반응률은 화학요법과 조합될 때 대략적으로 60%이고 화학요법-불응 환자에서 단독으로 투여될 때 20% 미만이다.
PTEN(포스파타아제 및 텐신 동족체)의 발현의 손실은 물론, BRAF(세린/트레오닌-단백질 키나아제 B-Raf) 및 PI3K(포스파티딜이노시톨 3-키나아제)와 같은 다른 EGFR 하류 유전자의 돌연변이를 활성화하는 것, 및 다른 EGFR 조절 단백질에서의 변화는 이제까지 결정적이지 않은 결과를 갖는 항-EGFR 치료에 대한 반응에 있어서 유력한 후보로서 평가되고 있다. 이들 유전자에서 돌연변이 사이의 상관성 및 항-EGFR 치료에 대한 반응에 관한 정보는 드 루크 등의 문헌, "화학요법-불응성 전이 결장암에서 세투시마브 플러스 화학요법의 효험에 대한 KRAS, BRAF, NRAS, 및 PIK3CA 돌연변이의 효과: 회고 컨소시엄 분석", 란셋 종양학회지-2010, 11권, 753-762쪽으로부터; 또는 루파키스 등의 문헌, "전이성 결장암을 갖는 환자에서 세투시마브 플러스 이리노테칸의 혜택의 예측에서 1차 종양과 전이 대한 PTEN 발현 및 KRAS 돌연변이", 임상종양학회지-2009, 27권, 2622-2629쪽에서 유도될 수 있다.
항-EGFR moAb에 대한 반응의 마커로서 EGFR의 잠재적 역할을 설명하도록한 이제까지 수행된 연구는 결정적이지 않다. 면역조직화학에 의해 검출된 바와 같이, EGFR 단백질 발현은 항-EGFR moAb에 대한 반응의 신뢰할만한 예측 마커가 아니다. 그러나, 항-EGFR moAb에 대한 반응의 잠재적 바이오마커로서 EGFR 유전자 복제 개수를 지지하는 증가하는 증거가 있다. 항-EGFR moAb-기반 치료에 대해 반응하는 EGFR 유전자에서의 뉴클레오티드 변화의 연관성을 고려할 때, 기술의 현재 수준, 특히 곤칼브스 등 "EGFR 세포외 도메인의 다형성은 세투시마브-기반 치료를 수용하는 전이성 결장암 환자에서 무진행 생존과 연관됨", BMC 암-2008, 8권, 169쪽은 mCRC 환자에서 세투시마브 혜택과 연관된 아미노산 치환 R521K를 초래하는, EGFR 유전자의 세포외 부분에서 다형성을 설명한다. 다형성 또는 단일 뉴클리오티드 다형성은 데이터베이스 인셈블(www.ensemble.org)로부터 검색가능한, 2011년 1월부터 변이 CM942312로서 식별된 것이다. 그것은 젠뱅크로부터 2011년 06월 26일에 이용가능한, NM_005228 버전 3로서 식별된 mRNA 서열에서 위치 521 AGG-AAG에서의 코돈 변경에 대응한다.
부가적으로, 문헌 WO2008/88860은 전이성 또는 비-전이성 위장 종양 또는 EGFR 유전자에서 다형성 R497K를 갖는 악성 종양을 갖는 환자는 단일 제제 항-EGFR moAb-기반 치료(예, 세투시마브 또는 패니투무마브)에 대한 반응성을 나타내는 경향이 있다. 이러한 돌연변이는 곤칼브스 등(위에)에 의해 개시된 바와 동일하지만, 고대의 지정으로 식별된다. 최종적으로, 문헌 WO20050854732는 환자에서 암의 치료를 위한 EGFR-표적 치료제의 감소된 효험으로, EGFR 단백질의 과발현을 유도하는, EGFR 유전자의 조절 영역에서 12개의 다형성의 연관성을 개시한다.
요약하면, 기술의 현재 수준에 포함되는 문헌에서 나타난 결과는 결정적이지 않을 뿐만 아니라, 여전히 항-EGFR mAb-기반 치료로부터 혜택을 받지 못하는 야생형 KRAS 종양을 갖는 mCRC 환자의 일부를 완전하게 설명하지 못한다.
위의 관점에서, 그러므로 mCRC를 갖는 환자에서 항-EGFR moAb 치료에 대한 저항의 추가적인 예측하는 바이오마커를 식별하는 것이 필요하다.
발명자는 암 치료에 사용된 일부 moAb를 갖는 치료에 대한 저항과 상관되는 EGFR(도메인 Ⅲ)의 세포외 도메인에서 돌연변이를 식별했다. 특히, 본 발명은 EGFR 단백질의 위치(492)에서 아르기닌 아미노산 치환에 의한 세린의 놀라운 식별을 토대로 한다. 돌연변이된 단백질은 SEQ ID NO:10으로서 여기에 식별된 아미노산 서열을 가진다. 야생형 단백질은 아미노산 서열 SEQ ID NO: 8을 가진다. 돌연변이는 S492R로 여기 알려진다.
돌연변이를 갖는 개인은 세투시마브로의 치료에 대해 저항을 나타냈고, 따라서 그러한 치료적 접근을 유용하게 하고, 그리고 다른 약물 전략을 강제가능하게 했다.
따라서, 본 발명의 제 1 측면은 SEQ ID NO: 1(TKIIRNRGE)를 포함하는 펩티드 서열에 관한 것이다. 이러한 아미노산 서열은 아미노산 서열 SEQ ID NO: 8에 대응하는, EGFR을 코드화하는 전체 아미노산 서열로부터 유도된 단편이고, 위치 492에서 세린은 아르기닌에 의해 치환된다.
바람직하게는, SEQ ID NO: 1을 포함하는 돌연변이된 펩티드는 암 치료에서 사용에 관련이 있는 세투시마브와는 달리 항-EGFR moAb에 여전히 민감하다. 특히 그것은 전이성 결장암(mCRC)의 치료 및 두경부암에 대한 화학요법에 유용한 moAb에 민감하다.
제 2 측면에서 본 발명은 SEQ ID NO: 1에 대한 서열 코딩을 포함하는 올리고뉴클레오티드를 목적으로 한다.
본 발명의 또 다른 측면은 SEQ ID NO: 3(gggacctccggtcagaaaa) 및 4(cggtgacttactgcagctgttt)로 구성되는 프라이머의 세트이다.
이러한 프라이머의 세트는 EGFR 코딩 영역의 부분을 포함하는 게놈 영역을 증폭시키는 것을 허용하고 본 발명의 돌연변이를 초래하는 뉴클레오티드 변경이 위치된다. 따라서 그들은 발명자에 의해 식별된 신규한 아미노산 돌연변이와 관련된다.
특히, 본 발명은 EGFR 단백질의 위치 492(S492R로서 여기에 공지된 돌연변이)에서 아르기닌 아미노산 치환에 의한 세린의 놀라운 식별을 토대로 한다. 이러한 아미노산 변경은 EGFR 유전자의 mRNA 변종 1의 위치 1722에서 뉴클레오티드 변경 C→A(C1722A로서도 여기에 공지됨)의 결과이다. 본 발명의 아미노산 변경은 또한 EGFR 유전자의 mRNA 변종 1의 뉴클레오티드 위치 1720에서 뉴클레오티드 변경 A→G(A1720G로도 공지됨)의 결과일 수 있다. 최종적으로, 본 발명의 아미노산 돌연변이는 또한 EGFR 유전자의 mRNA 변종 1에서 다음의 뉴클레오티드(들) 변경의 각각의 결과: 위치 1722에서 C→G(C1722G로도 여기에 공지됨), 위치 1720에서 A→C 및 위치 1722에서 C→T(A1720C/C1722T로도 여기에 공지됨), 위치 1720에서 A→C(A1720C로도 여기에 공지됨); 및 위치 1720에서 A→C 및 위치 1722에서 C→G(A1720C/C1722G로도 여기에 공지됨)일 수 있다.
본 발명의 또 다른 측면은 SEQ ID NO: 5(cacctctgtttcttataatt)로 구성되는 올리고뉴클레오티드이다.
이러한 SEQ ID NO: 5의 올리고뉴클레오티드는 EGFR 코딩 영역의 돌연변이된 영역에 대해 상보적이고 여기서 본 발명의 돌연변이를 초래하는 뉴클레오티드 변경이 위치된다. 따라서, 그것은 돌연변이를 싣고 있는 뉴클레오티드 서열의 단편과 교잡된다. 그것은 위에 개시된 위치 1722 및/또는 1720에서 뉴클레오티드 변경 C→A를 검출하는 것을 허용한다.
이미 위에 지시된 바와 같이, 위의 뉴클레오티드 변경의 각각은 EGFR 유전자의 mRNA, 트랜스크립트 변종 1 서열을 말한다(ERBB1, PIG61, 원종양유전자 c-ErbB-1, 조류 적아세포 백혈병 바이러스(v-erb-b) 종양유전자 동족 수용체 타이로신-단백질 키나아제 erbB-1, 또는 HER1로도 공지됨). EGFR 유전자의 mRNA, 트랜스크립트 변종 1의 서열은 임의의 그것의 변종은 물론 SEQ ID NO: 7(또는 2011년 06월 26일에 이용가능한, 젠뱅크 기탁 번호 NM_005228.3)에 대응하는 것이고 여기서 언급된 변종은 EGFR 단백질에 대해 코딩한다. EGFR 단백질은 SEQ ID NO: 8(2011.07.17의 젠뱅크 기탁 번호 NP_005219.2 버전) 또는 EGFR 단백질의 기본 구조를 유지하는 임의의 변종에 대응한다.
또한 본 발명의 또 다른 측면은 SEQ ID NO: 6(cacctctgttgcttataa)로 구성되는 올리고뉴클레오티드이다.
이러한 SEQ ID NO: 6의 올리고뉴클레오티드는 EGFR 코딩 영역의 야생형 영역에 대해 상보적이고 여기서 식별된 돌연변이가 위치된다(돌연변이가 존재하는 경우에).
올리고뉴클레오티드는 세린 변경에 의해 아르기닌으로 유도하는 돌연변이의 존재 여부를 검출하는 것을 허용한다.
본 발명의 또 다른 측면은 앞서 정의된 바와 같이 SEQ ID NO: 5에 대응하는 올리고뉴클레오티드를 포함하는 키트이다.
바람직하게는, 본 키트는 돌연변이된 EGRF 코딩 영역에 상보적인 탐침을 포함하기 때문에 쉽고 빠른 방법으로 S492R 돌연변이의 존재를 검출하는 유용한 툴이다.
본 발명의 또 다른 측면은 세투시마브 및/또는 패니투무마브를 포함하는 치료 요법에 대한 대상의 반응의 예측에서 사용을 위해, 위에 정의된 바와 같은 키트이다.
또한, 본 발명은 유전자형 방법, 및/또는 단백질 서열화 방법으로 구성되는 그룹으로부터 선택된 수단에 의해 SEQ ID NO: 8의 위치 492에서 아미노산을 결정하는 것을 포함하는, 대상으로부터 취해진 시료에서 SEQ ID NO: 8에 대응하는 아미노산 서열의 위치 492에서 아르기닌의 존재 또는 부재를 식별하는 인 비트로 방법에도 관련된다. 본 발명의 인 비트로 방법은 SEQ ID NO: 1(TKIIRNRGE)을 포함하는 펩티드 서열을 식별하는 것을 허용한다.
최종적으로, 본 발명의 또 다른 측면은 세투시마브 및/또는 패니투무마브를 포함하는 대상 치료 요법의 반응을 예측하는 인 비트로 방법이고, 그 방법은: ⅰ) 위에 개시된 방법에서 정의된 바와 같이, 대상으로부터 취해진 시료에서 SEQ ID NO: 8에 대응하는 아미노산 서열의 위치 492에서 아르기닌의 존재 또는 부재를 결정하는 단계; ⅱ) 세투시마브를 포함하는 치료 요법에 대한 대상의 저항과 단계 ⅰ)에서 식별된 아르기닌의 존재를 상관시키는 단계, 또는 패니투무마브를 포함하는 치료 요법에 대한 대상의 반응과 단계ⅰ)에서 식별된 아르기닌의 존재를 상관시키는 단계를 포함한다.
세투시마브 및/또는 패니투무마브를 포함하는 치료 요법에 대한 대상의 반응을 예측하는 인 비트로 방법의 실시는 대상에 대한 더 적합한 치료를 수용하는 이점을 내포하고, 특히 대상이 암으로 영향받고 있다면, 대상과 치료의 성공에서 핵심적인 측면인, 시간낭비를 발생시키는 치료적으로 잘못되거나 충분히 유용하지 않은 접근을 피한다.
실시예 3에 관련된, 도 1은 야생형 EGFR(wt EGFR) 및 S492R EGFR과 상호작용하도록 세투시마브 및 패니투무마브의 상호작용을 나타내는, 직접 결합 분석이다. WT-ECD-Fc는 세포외 도메인 Fc(결정화가능한 단편)를 의미하고; S492R-ECD-Fc는 세포외 도메인 Fc를 의미하며(결정화가능한 단편); [Ab](ng/ml)는 밀리리터 당 나노그램에서 시험된 항체 농도이고; 그리고 OD 450/620 nm는 광학 밀도이다.
도 2a는 EGFR 도메인 Ⅲ와 세투시마브 사이의 상호작용의 구조적 모델링이고, 양쪽 분자의 인터페이스에서 본 발명의 돌연변이의 위치(EGFR 단백질의 위치 492에서 아르기닌)를 확인한다.
실시예 3과 관련된 도 2b는 세투시마브 또는 패니투무마브의 존재 하에 배양된 야생형 EGFR(wt EGFR) 및 S492R EGFR 돌연변이를 과발현시키는 총 그리고 인산화된 EGFR(Tyr1068에서; 여기 pEGFR로 명명됨) NIH3T3 세포 용해물의 웨스턴 블럿 분석이다. Tub는 튜블린을 의미한다.
실시예 3에 관련된, 도 2c는 세투시마브 및 패니투무마브로 면역이된, 야생형 EGFR (wt EGFR) 및 S492R EGFR을 발현시키는 NIH3T3의 용해물의 총 EGFR의 웨스턴 블럿 분석이다. E는 공백; SN은 상청액 그리고 IP는 면역침강됨을 의미하고; 그리고 I는 입력을 의미한다.
실시예 3에 관련된, 도 2d는 1차 항체로서 세투시마브 또는 패니투무마브로 배양되고 인간 IgG에 지향된 피코에리트린과 접합된 2차 항체를 사용하여 야생형 EGFR(wt EGFR) 및 S492R EGFR 돌연변이를 과발현시키는 트립신화된 NIH3T3의 유동 세포계수 결합 분석이다. C는 카운트를 의미하고; FL2H는 피코에리트린(PE) 형광을 검출하도록 사용된 585±21의 대역 통과를 갖는 형광 검출의 제 2 채널에서 최대 신호 강도를 나타내고; E는 공백을 의미한다.
도 2a는 EGFR 도메인 Ⅲ와 세투시마브 사이의 상호작용의 구조적 모델링이고, 양쪽 분자의 인터페이스에서 본 발명의 돌연변이의 위치(EGFR 단백질의 위치 492에서 아르기닌)를 확인한다.
실시예 3과 관련된 도 2b는 세투시마브 또는 패니투무마브의 존재 하에 배양된 야생형 EGFR(wt EGFR) 및 S492R EGFR 돌연변이를 과발현시키는 총 그리고 인산화된 EGFR(Tyr1068에서; 여기 pEGFR로 명명됨) NIH3T3 세포 용해물의 웨스턴 블럿 분석이다. Tub는 튜블린을 의미한다.
실시예 3에 관련된, 도 2c는 세투시마브 및 패니투무마브로 면역이된, 야생형 EGFR (wt EGFR) 및 S492R EGFR을 발현시키는 NIH3T3의 용해물의 총 EGFR의 웨스턴 블럿 분석이다. E는 공백; SN은 상청액 그리고 IP는 면역침강됨을 의미하고; 그리고 I는 입력을 의미한다.
실시예 3에 관련된, 도 2d는 1차 항체로서 세투시마브 또는 패니투무마브로 배양되고 인간 IgG에 지향된 피코에리트린과 접합된 2차 항체를 사용하여 야생형 EGFR(wt EGFR) 및 S492R EGFR 돌연변이를 과발현시키는 트립신화된 NIH3T3의 유동 세포계수 결합 분석이다. C는 카운트를 의미하고; FL2H는 피코에리트린(PE) 형광을 검출하도록 사용된 585±21의 대역 통과를 갖는 형광 검출의 제 2 채널에서 최대 신호 강도를 나타내고; E는 공백을 의미한다.
일반적으로, 다음의 단어 또는 어구는 설명, 실시예 및 청구항에서 사용될 때 지시된 정의를 가진다.
기술의 현재 수준에서 그리고 또한 여기 사용된 바와 같은 용어 "치료 요법"은 전암성 병변, 암 또는 암 전이의 성장을 예방하거나, 지연시키거나, 저지하거나 또는 역행시키도록 의도된 임의의 치료를 말한다. 그것은 화학 요법, 방사선 치료, 면역 요법, 단일클론 항체 치료 또는 다른 방법을 포함한다.
"반응"은 종양 크기에서의 측정가능한 감소 또는 질병의 증거 또는 질병 진행, 안정적인 질병, 무진행 생존의 증가 또는 연장 또는 독성에서의 감소로부터 선택되는, 그러나 그것으로 한정되지 않는, 임상 또는 비임상 중 어느 하나의 종류의 개선으로 이해된다.
"무진행 생존"은 암이 성장하지 않는 치료 동안 그리고 이후 시간의 길이를 나타낸다. 무진행 생존은 환자가 안정적 질병을 겪은 시간의 양은 물론, 환자가 완전한 반응 또는 부분적 반응을 겪는 시간의 양을 포함한다.
치료에 대한 "완전한 반응"은 종양 및 모든 질병의 증거가 사라진, 가치있지만 측정가능하지 않은 질병을 갖는 환자를 정의한다.
치료에 대한 "부분 반응"은 완전한 반응보다 적은 반응을 갖는 환자를 정의한다.
표현 "유전자형 방법"은 소정 위치에서 뉴클레오티드를 식별하도록 동일한, 유전자형을 결정하기에 적합한 모든 이러한 방법론 및 과정을 포함한다. 언급된 방법론의 실시예는 생어 서열화, 파이로서열화, 대립 유전자-특이적 PCR, 변성 고압 액체 크로마토그래피(DHPLC), 대립 유전자 특이적 프라이머 연장(ASPE), DNA 바이오칩/마이크로어레이 및 동적 대립 유전자-특이적 교잡(DASH)을 포함한다.
"단백질 서열화 방법"은 단백질이 채택하는 형태 및 임의의 비-펩티드 분자와 혼합되는 정도는 물론, 단백질의 아미노산 서열을 결정하는 것을 허용하는 임의의 기술로 이해되어야 한다. 아미노산 성분의 결정은 아미노산의 가수분해 또는 분리에 의해 수행될 수 있다. 공지된 기술은 생어 서열화, 에드먼 분해 및 질량 분석을 포함한다.
이미 위에 설명된 바와 같이, 기술의 현재 수준에 따른 교시는 한편으로, 대응하는 단백질의 과발현을 초래하는 EGFR 유전자의 조절 영역에서의 돌연변이가 환자에서 암의 치료를 위한 EGFR-표적 치료제의 감소된 효험과 연관된다(WO2005/854732 참조);는 것은 물론 EGFR 유전자의 코딩 영역에서의 뉴클레오티드 변경이 전이 또는 비-전이 위장 종양 또는 악성 종양을 갖는 환자에서 단일 제제 항-EGFR mAb 기반 치료에 대한 반응성과 연관된다(WO2008/88860 참조)는 것을 제안한다. 게다가 예를 들어, 적어도 인 비트로 분석에 의해, 뉴클레오티드 변경의 효과가 EGFR 유전자의 코딩 영역에서 식별되고, 그렇기 때문에 EGFR 단백질에 영향을 미친다는 더 확인되지 않은 모순적인 결과가 있다. 결과적으로, WO2008/88860에서 식별된 뉴클레오티드 변경이 반응성을 일으키는 돌연변이인지, 또는 반대로, 그것과 연결 불안정에 있고, 그리고 또 다른 유전자에 위치된 또 다른 돌연변이가 반응성을 일으키는지 분명하지 않다.
기술의 현재 상태에서 개시된 발견들과는 반대로, 본 발명은 EGFR 유전자의 코딩 영역에서 신규한 돌연변이를 토대로 한다. 본 발명의 신규한 돌연변이는 mCRC 및/또는 두경부암을 갖는 환자의 moAb 기반 치료에 대한 반응성을 예측하기에 유용하다(편평상피암).
위에 이미 나타난 바와 같이, 개시된 뉴클레오티드 변경의 각각은 SEQ ID NO: 8에 대응하는 단백질 서열의 위치 492에서 아르기닌으로의 세린의 치환으로 유도한다.
세린 492는 EGFR의 세포외 도메인 내에 위치된다(도메인 Ⅲ로서도 공지됨). 아르기닌은 벌키 측쇄를 갖는 아미노산인 반면에, 세린은 극성 아미노산이다. 그렇기 때문에, 본 발명은 벌키 아미노산(예, 아르기닌)에 의해 EGFR 단백질(즉, 세린)의 위치 492에 위치된 아미노산의 치환이 EFGR에 대한 mAb 세투시마브의 결합을 방해한다는 발견을 토대로 한다. 달리 말해서, 세투시마브에 결합하는 EGFR의 에피토프에 위치된 본 발명의 아미노산 변경은 세투시마브-EGFR 상호작용을 특히 방해한다.
또한, 그리고 더 놀랍게도, 세투시마브 저항을 초래하는 본 발명의 아미노산 변경은 전이성 결장암(mCRC)의 암 치료를 위해 폭넓게 사용되는 moAb인, 또 다른 moAb, 즉, 패니투무마브의 EGFR 결합에 영향을 미치지 않는다.
따라서, 본 발명은 mCRC를 겪는 환자를 위한 적합한 치료를 선택하는 방법을 제공하고, 그 적합한 치료는 세투시마브 및/또는 패니투무마브의 유효량의 투여를 포함한다.
SEQ ID NO: 1을 포함하는 격리된 펩티드는 암 치료의 분야에서 큰 관심의 EGFR 단백질의 돌연변이된 형태의 검출로 유도하는 핵심 제품이다. 이러한 단백질의 돌연변이된 형태는 또한 SEQ ID NO: 1에 대한 시퀀스 코딩을 포함하는 올리고뉴클레오티드의 형태로 검출가능하다.
바람직한 실시예에서 SEQ ID NO: 1에 대한 올리고뉴클레오티드 코딩은 SEQ ID NO: 2, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16 및 SEQ ID NO: 17로 구성되는 그룹으로부터 선택된 핵산 서열을 포함한다. 모든 이러한 서열은 식(Ⅰ):
ccaaaattataXYZaacagaggtga (I)
에서 정의된 일반 서열에 의해 개략적으로 표현될 수 있고 여기서 뉴클레오티드 XYZ은 AGA, AGG, CGT, CGC, CGA 및 CGG로 구성되는 그룹으로부터 선택된 뉴클레오티드 조합이다.
본 발명에서 개시된 EGFR 유전자에서 뉴클레오티드 변경의 검출은 다음의 방법으로 바람직하게 수행된다: SEQ ID NO: 9에 대응하는 표적 DNA 서열의 증폭 후에, 앰플리콘은 돌연변이된 탐침(SEQ ID NO: 5) 및 야생형 탐침(SEQ ID NO: 6)을 사용하여 분석된다. SEQ ID NO: 9은 2011년 06월 19일에 이용가능한, 젠뱅크 수탁 번호 NG_007726, 버전 1(NG_007726.1)에 대응한다.
바람직한 실시예에서 돌연변이된 탐침은 SEQ ID NO: 5에 대응하는 것인 반면에, 야생형 탐침은 SEQ ID NO: 6에 대응하는 것이며, 이들 탐침은 5' 단부에서 6-카르복시플루오레세인(FAM) 및 라벨 VIC®로, 그리고 3' 단부에서 형광의 비-형광 익스팅터를 포함하는 마이너 그루브 바인더(MGB)로 라벨링된다. 개략적으로, 탐침은 다음과 같다:
야생형 탐침(라벨링된 SEQ ID NO: 6):
VIC-5'-CACCTCTGTTGCTTATAA-3'-MGB
돌연변이-특정 탐침(라벨링된 SEQ ID NO: 5):
FAM-5'-CACCTCTGTTTCTTATAATT-3'-MGB
EGFR 유전자의 표적 단편으로 일단 가수분해되면 탐침은 또한 동일한 것의 특정 검출을 허용하는 다른 적합한 라벨을 포함할 수 있다. 다른 라벨의 실시예는 화학 발광 라벨, 방사성 동위 원소의 라벨, 비색 라벨 등을 포함한다.
출원인의 지식으로는, 본 발명의 돌연변이를 초래하는 뉴클레오티드 변경이 위치되는 EGFR 게놈 영역의 특정 부분은 산업적 응용성을 갖는 어떠한 돌연변이도 그 안에서 식별되지 않았기 때문에 기술의 현재 수준에서 관심이 없었다. 결과적으로, 기술의 현재 수준은 언급된 게놈 영역을 가수분해하고 증폭시키는 프라이머를 개시하지 않는다.
그러므로, 본 발명의 돌연변이를 초래하는 뉴클레오티드 변경이 위치되는EGFR 코딩 영역의 부분을 포함하는 게놈 영역을 증폭시키도록 특별히 설계된 본 발명에 개시된 신규한 프라이머는 발명자에 의해 식별된 신규한 아미노산 돌연변이와 분명히 연결된다.
증폭을 위해 사용된 바람직한 프라이머는 SEQ ID NO: 3 및 SEQ ID NO: 4에 대응하는 이들이다. 이들 프라이머는 EGFR 유전자, SEQ ID NO: 9(2011년 06월 19일에 이용가능한, 젠뱅크 수탁 번호 NG_007726, 버전 1(NG_007726.1)에 대응)의 게놈 서열의 뉴클레오티드 위치 146318-146297, 및 146253-146271에 각각 위치된다.
이들 방법은 본 발명의 뉴클레오티드 변경을 식별하도록 사용된 기술에 의해 한정되지 않는다. 관심의 뉴클레오티드 변경의 검출에 적합한 해당 기술분야에 공지된 임의의 기술이 본 발명의 방법에 사용될 수 있다. 적합한 기술은 증폭 반응을 포함하지만 그것에 한정되지 않는다. 바람직한 실시예에서, 사용된 증폭 기술은 폴리메라아제 연쇄 반응이다. 더 바람직한 실시예에서, PCR은 실시간 PCR이다. 증폭 조건은 해당 기술분야의 당업자에 의해 필요에 따라, 그리고 용이하게 조절될 수 있다; 본 발명의 방법에 적합한 증폭 조건의 실시예는 실시예 섹션에 제공된다.
대안적으로, 관심의 돌연변이는 관심의 영역에 존재하는 코돈 또는 아미노산 의 정보를 주는, 생어 서열화와 같은, 서열화 반응에 의해 검출된다. 돌연변이를 검출하기 위한 적합한 방법의 실시예는 생어 서열화, 파이로서열화, 대립 유전자-특이적 PCR, 변성 고압 액체 크로마토그래피(DHPLC)를 포함한다.
따라서, 대상으로부터 취해진 시료에서 SEQ ID NO: 8에 대응하는 아미노산 서열의 위치 492에서 아르기닌의 존재 또는 부재를 식별하기 위한 본 발명의 인 비트로 방법은 유전자형 방법론을 사용하여 바람직하게 실행된다. 또 다른 바람직한 실시예에서 SEQ ID NO: 8에 대응하는 아미노산 서열의 위치 492에서 아르기닌의 존재 또는 부재는 단백질 서열화 방법에 의해 단백질 레벨에서 실행된다.
본 발명에 따른 키트의 바람직한 실시예에서, 키트는 SEQ ID NO: 5(cacctctgtttcttataatt)로 구성되는 올리고뉴클레오티드 및 SEQ ID NO: 6(cacctctgttgcttataa)로 구성되는 또 다른 올리고뉴클레오티드를 더 포함한다.
더 바람직한 실시예에서 키트는 KRAS 및/또는 PIK3CA 및/또는 BRAF 유전자에서 돌연변이를 검출하기 위한 시약을 더 포함한다.
위에 노출된 바와 같이, 이들 유전자는 moAb(KRAS)로의 암(즉 mCRC)의 치료에 대한 저항과 관련되거나, 또는 그들은 약물 표적 치료에 대한 유력한 후보로서 평가된 EGFR 조절 단백질(PIK3CA 및 BRAF)에 대해 코드화한다.
그런 후에, 더욱 더 바람직한 실시예에서, 키트는 또한 카라페티스 등, "발전적 결장암에서 세투시마브로부터의 K-ras 돌연변이 및 혜택", 뉴 잉글랜드 의학 저널-2008, 359권, 1757-1765쪽에 의해 정의된 바와 같은 G12A; G12C; G12D; G12R; G12S; G12V; G13A; G13C, G13D; G13V로 구성되는 그룹으로부터 선택된 KRAS에서 돌연변이를 검출하기 위한 툴과 수단(시약)을 포함한다. 모든 이러한 돌연변이는 2011년 07월 24일로부터 젠뱅크 기탁 번호 NP_004976.2(GTP아제 KRas 이소폼 b 전구체로 명명됨) 및 2011년 07월 24일로부터 NP_203524.1(GTP아제 KRas 이소폼 a 전구체로 명명됨)로 식별된 K-ras의 단백질 서열의 코돈 12 및 13 상에 위치된다.
또 다른 바람직한 실시예에서 키트는 또한 2011년 07월 17일로부터 젠뱅크 기탁 번호 NP_006209.2를 갖는 PIK3CA 단백질; 및/또는 2011년 07월 24일로부터 젠뱅크 기탁 번호 NP_004324.2로 식별되는 BRAF의 단백질 서열의 코돈 600 상에 위치된 V600E 돌연변이에 대해 코드화하는 PIK3CA 유전자의 엑손 9 및 20에서 돌연변이를 검출하기 위한 툴과 수단(시약)을 포함한다.
세투시마브 및/또는 패니투무마브를 포함하는 치료 요법에 대한 대상의 반응의 예측에서의 사용을 위한, 본 발명의 키트는 전이 결장암 및 두경부암으로 구성되는 그룹으로부터 선택된 암에 대한 대상의 반응을 예측하기 위한 바람직한 실시예에 있다. 바람직하게 키트는 전이성 결장암의 경우에 반응의 예측을 위한 것이다.
세투시마브 및/또는 패니투무마브를 포함하는 치료 요법에 대한 대상의 반응을 예측하는 인 비트로 방법의 바람직한 실시예에서, 대상은 세투시마브를 포함하는 치료 요법으로 이미 치료되었다.
또 다른 바람직한 실시예에서, 예측의 인 비트로 방법은 암에 걸린 대상에게 적용가능하다. 바람직하게 암은 전이 결장암 및 두경부암으로 구성되는 그룹으로부터 선택된다.
세투시마브 및/또는 패니투무마브를 포함하는 치료 요법에 대한 대상의 반응을 예측하는 인 비트로 방법은 암에 걸린 대상에게 특히 적합하다. 특히 바람직한 암은 전이성 결장암 및 두경부암으로 구성되는 그룹으로부터 선택된다.
본 발명은 ⅰ) 본 발명의 S492R EGFR 돌연변이의 존재를 결정하는 단계; 및 ⅱ) 돌연변이가 부재하다면, 세투시마브, 또는 그것의 조성물의 유효량을, 또는 돌연변이가 존재한다면, 패니투무마브, 또는 그것의 조성물을 언급된 대상에게 투여하는 단계를 포함하는, 암, 바람직하게 mCRC 또는 두경부암에 걸린 대상을 치료하는 방법을 더 제공한다.
항-EGFR moAb, 세투시마브 및 패니투무마브는 조성물로서, 단독으로, 또는 화학요법 약물과 같은, 다른 조성물을 포함하는 치료 요법에서 투여될 수 있다.
항-EGFR moAb, 세투시마브 및 패니투무마브, 또는 그들의 조성물은 암(mCRC 또는 두경부)을 치료하기에 효과적인 양으로 그리고 예를 들어, 약학적으로 허용가능한 담체를 포함하는, 임의의 적합한 제형으로 투여되거나 전달된다. 제형은 하나 이상의 방부제 및/또는 안정화제를 더 포함할 수 있다.
세투시마브 및/또는 패니투무마브를 포함하는 치료 요법에 대한 대상의 반응을 예측하기 위한 인 비트로 방법은 본 발명의 EGFR 유전자에서의 뉴클레오티드 변경이 검출될 수 있는, 종양을 포함하는 시료에서 실행된다. mCRC의 경우에, 시료는 소스로부터 얻어지는 바와 같이 직접적으로 또는 시료의 전처리에 이어서 사용될 수 있다. 시료는 언급된 종양에 인접한 정상 조직을 추가적으로 포함할 수 있다. 따라서, mCRC의 경우에 시료는 1차 결장암 생체검사 또는 그것의 전이의 생체검사로부터 선택된다. 달리 말해서, 시료는 1차 종양 및 전이를 포함하는 결장암 시료로부터의 생체검사일 수 있다. 바람직한 실시예에서, 전이는 간 조직에 있다.
대상은 인간 또는 인간이 아닌 포유류를 포함하지만 그것으로 한정되지 않는 임의의 포유류를 포함한다. 바람직하게 대상은 인간이다.
본 발명의 S492R 돌연변이를 갖는 환자는 무진행 생존에서 임의의 적합한 임상 또는 준임상 증가 또는 연장에 의해 측정되는 바와 같이 세투시마브를 포함하지 않는 치료 요법에 대해 반응을 나타내는 경향이 있다.
바람직한 실시예에서 치료 요법은 단독으로 또는 이리노테칸, 옥살리플라틴 및/또는 5-플루러유러실(5-FU 또는 5FU)을 기반으로한 화학치료 요법과 조합해서 세투시마브이다. 바람직한 실시예에서 치료 요법은 단독으로 또는 이리노테칸, 옥살리플라틴 및/또는 5-플루러유러실을 기반으로한 화학치료 요법과 조합해서 패니투무마브이다.
설명 및 청구항에 걸쳐 단어 "포함하다" 및 그 단어의 변형은 다른 기술적 특징, 첨가제, 성분, 또는 단계를 배제하도록 의도되지 않는다. 또한 단어 "포함하다" 및 그것의 변형은 표현 "구성된다"를 포함한다. 본 발명의 추가적인 대상, 이점 및 특징은 설명의 검토 시에 해당 기술분야의 당업자에게 명백해질 것이고 또는 본 발명의 실시에 의해 습득될 수 있다. 다음의 실시예 및 도면은 도시에 의해 제공되고, 그들은 본 발명을 한정하도록 의도되지 않는다. 또한, 본 발명은 여기에 설명된 특정 그리고 바람직한 실시예의 모든 가능한 조합을 포함한다.
실시예
실시예
1. 종양 시료 및 환자
종양 시료가 mCRC 환자에 대한 진단 동안 또는 수술 절차로부터 얻어졌다. 생체 검사가 가장 접근가능한 악성 병변(1차 종양 또는 전이)으로부터 얻어졌다.
필요할 때, 세투시마브 기반 치료에 대한 최초 반응 후에 종양 재성장(질병 진행)을 나타내는 환자로부터 종양 병변의 생체 검사가 수집되었다. 일치된 정상 조직으로부터의 시료가 대조군으로서 얻어졌다.
DNA 추출 및 KRAS(코돈 12 및 13), BRAF(V600E)의 돌연변이 분석이 몽타구에트 등, "미토겐-활성화된 단백질 키나아제 포스파타아제-1(MKP-1)은 전이성 결장암 환자에서 항-상피세포 성장 인자 수용체(EGFR) 항체 세투시마브에 대한 반응을 손상시킨다", 영국 암 저널-2010, 102권, 1137-1144쪽에 의한 문헌에서 돌연변이 분석에서 앞서 설명된 바와 같이 수행되었다.
PIK3CA의 돌연변이 분석이 드 루크 등의 의사록, "화학요법-난치성 전이 결장암에서 세투시마브 플러스 화학요법의 효험에 대한 KRAS, BRAF, NRAS, 및 PIK3CA 돌연변이의 효과: 회고 컨소시엄 분석", 란셋 종양학회지-2010, 11권, 753-762쪽에 개시된 바와 같이, DxS PI3K 돌연변이 테스트 키트(DxS, 맨체스터, UK)로 수행되었다.
EGFR의 증폭이 파오 등, "제피니티브 또는 에를로티니브에 대해 폐 선암의 얻어진 저항은 EGFR 키나아제 도메인에서 제 2 돌연변이와 연관된다", 국립과학도서관 의학지 2005; 2:e73에서 앞서 설명된 바와 같이, LSI EGFR/CEP7 탐침(애버트 몰레큘러 인코퍼레이션, 데스 플레인즈, 일리노이)을 사용하여 형광동소혼성화(FISH)에 의해 평가되었다.
EGFR S492R의 분석이 직접 서열화에 의해 수행되었다. 간략하게, 돌연변이된 영역을 포함하는 EGFR 엑손(12)의 영역이 다음의 조건으로 적용된 바이오시스템 베리티 서멀사이클러에서 프라이머 5'-TTGCAGTCGTCAGCCTGAAC-3'(직접 프라이머 또는 SEQ ID NO: 11) 및 5'-TTAAATGGGAATAGCCCTTCAATATT-3'(역 프라이머 또는 SEQ ID NO: 12)로 증폭되었다: 10분 동안 95℃; 95℃의 40 사이클, 1분, 60℃, 1' 30" 및 72℃ 1분; 및 72℃에서 10분의 최종 연장. 제조자의 지침에 따라 빅다이 v3.1(적용된 바이오시스템, 포스터 시티, 캘리포니아)로 수행되었고 그리고 3500Dx 유전자 분석기(적용된 바이오시스템) 상에 분석되었다. 시퀀스 데이터 파일이 SeqScape 소프트웨어(적용된 바이오시스템)를 사용하여 분석되었고 모든 돌연변이는 독립적인 PCR로 확인되었다. DNA의 PCR 증폭의 실시간 모니터링이 ABI 프리즘 7500 패스트(적용된 바이오시스템)에서, 각각의 탐침의 37.5 nM nM 및 각각의 프라이머의 37.5 nM을 사용하여 타크만 유니버셜 마스터 믹스(적용된 바이오시스템)로 수행되었다. 모든 결정은 내부-분석 변동을 최소화하도록 두 번씩 수행되었다.
실시예
2.
S492R
EGFR
돌연변이 및
세투시마브에
대한 1차 저항
세투시마브(에르비투스) 및 패니투무마브(벡티비스)가 하스피틀 델 마스 파머시로부터 얻어졌고, 양 단일클론 항체는 사용할 준비가 되었다. 제피티니브가 셀레크 케미칼(휴스톤, 텍사스, 미국)로부터 얻어졌고 DMSO에서 용해되었으며 부분표본화되어 -20℃에서 저장되었다. 정제된 EGF 재조합형 단백질은 칼바이오쳄(샌 디에고, 캘리포니아, 미국)으로부터 구입되고 PBS 0.1% BSA에서 용해되며, 부분 표본되고 그리고 -20℃에서 저장되었다.
EGFR 세포외 도메인이 시퀀스되었고 1차 종양 시료에서 KRAS 및 BRAF 돌연변이 상태가 세투시마브 기반 치료의 투여에 앞서 83명의 전이성 결장암 환자로부터 분석되었다. 그룹으로서, 이들 환자는 세투시마브를 받아들이기 전에 다른 치료 요법으로 충분히 미리-치료되었다. 환자의 82%에서, 세투시마브가 이리노테칸과 조합해서 주어졌다. 현저하게, 대응하는 EGFR 단백질(SEQ ID NO: 8)에서 S492R 아미노산 변경을 초래하는, SEQ ID NO: 7의 뉴클레오티드 1722에 대응하는 위치에서 C→A 뉴클레오티드 변화는 두 명의 환자의 시료에서 검출되었다. 양쪽 종양은 KRAS, BRAF 및 PIK3CA 야생형이었고 EGFR 유전자 증폭을 나타내지 않았다. S492R EGFR 돌연변이는 언급된 환자에 대해 이용가능한 일치된 정상 조직에서 검출되지 않았다.
실시예
3.
S492R
EGFR
돌연변이의 존재 및
세투시마브에
대한 저항
본 발명의 S492R EGFR 돌연변이가 세투시마브에 대해 관찰된 저항에 반응하는지 여부를 확인하기 위해, 전체 길이의 야생형 EGFR 및 S492R EGFR 돌연변이가 검출가능한 내생 EGFR 발현이 부족한 배양된 NIH3T3 마우스 배아 섬유아세포 셀 라인에서 이소성으로 발현되었다.
EGFR은 형질주입된 셀에서 세투시마브 또는 패니투무마브의 존재 하에서 천연 리간드 EGF로 자극되었다. 야생형 EGFR 셀에서, 세투시마브 및 패니투무마브 모두다 EGFR 활성화를 억제했고, 반면에 S492R 돌연변이를 전달하는 셀에서, 세투시마브를 제외한 패니투무마브가 EGF-유도된 EGFR 활성화를 효과적으로 차단했다(도 2b).
이들 결론은 세투시마브 또는 패니투무마브의 존재 하에 배양된 야생형 EGFR(wt EGFR) 및 S492R EGFR 돌연변이를 과발현시키는 총 그리고 인산화된 EGFR(Tyr1068에서; 여기 pEGFR로 명명됨) NIH3T3 세포 용해물의 웨스턴 블럿 분석인, 도 2b에서의 분석으로부터 유도되었다. 야생형 EGFR(wt EGFR) 및 S492R EGFR 돌연변이를 과발현시키는 NIH3T3 셀은 세투시마브 또는 패니투무마브(10㎍/ml)의 존재 하에 배양되었고, 2시간 후에 셀은 15분 동안 EGF 10㎍/mL로 자극되었다. 세포 용해물은 수용체의 활성화를 결정하도록 총 그리고 인산화된 EGFR(SEQ ID NO: 8로부터 Tyr1068)의 웨스턴 블럿 분석에 대상이 되었다. 세투시마브는 분석이 이러한 moAb로 수행될 때 pEGFR에 대응하는 대역에서 관찰되는 바와 같이, S492R EGFR 돌연변이 세포에서 유도된 리간드의 활성화를 돌이키게 할 수 없다.
용해물을 수집하기 위해, 세포를 PBS로 세정하고 용해 버퍼 논이데트 P-40 버퍼(트리스-HCL(pH=7.4) 50mM, NaCl 150mM, 1% NP40, EDTA 5 mM, NaF 5 mM, Na3VO4 2 mM, PMSF 1 mM, 류펩틴 5 ㎍/mL 및 아프로티닌 5㎍/mL)에서 긁어냈다. 4℃에서 30분 동안 흔든 후에, 시료를 30분 동안 13200 rpm에서 원심분리시키고 상청액을 부분 표본화하고 사용시까지 -20℃에서 저장했다. 시료(30 ㎍/레인)가 SDS-페이지에 대상이 되고 나일론 멤브레인에 전달되었다. 웨스턴 블럿팅이 신호 검출을 위해 겨자무과산화효소-접합된 2차 항체를 사용하여 표준 절차에 따라 수행되었다. 표적 단백질이 멤브레인의 향상된 화학 발광 처리 및 이어지는 X-레이 필름에 대한 노출 후에 시각화되었다. 이어지는 항체가 아래에 나열된 제조자로부터 구입되었다: 포스포 EGFR(Y1068 또는 Tyr1068), EGFR은 셀 시그널링 테크놀로지로부터 얻어졌다(베벌리, 매사추세츠, 미국).
게다가, 생화학 결합 분석은 물론 유동 세포분석법 및 면역 침강은 야생형 EGFR을 발현하는 셀에서, 세투시마브와 패니투무마브 모두는 EGFR을 결합시킬 수 있지만; 그러나, S492R EGFR을 발현하는 셀에서, 패니투무마브는 EGFR에 결합할 수 있는 반면에 세투시마브-EGFR 결합은 검출되지 않았다는 것을 나타냈다(도 1, 도 2c 및 도 2d).
도 1은 직접 결합 분석에 의해 인 비트로 야생형 EGFR 및 S492R EGFR 돌연변이와 상호작용하는 세투시마브 및 패니투무마브의 능력을 나타낸다.
위에 지시된 바와 같이, 이러한 분석은 S492R EGFR이 세투시마브로의 결합에 직접적으로 영향을 미친다는 것을 더 검증하도록 수행되었다. 인 비트로 생화학 결합 연구는 야생형 EGFR과 S492R 돌연변이의 세포외 도메인(EC)의 정제된 재조합 형태를 사용하여 수행되었다(도 1).
경쟁적인 결합 분석이 다음과 같이 수행되었다: 야생형(WT)에 결합하는 항-EGFR Ab 결합 그리고 EFGR의 돌연변이 세포외 도메인(ECD)이 경쟁적인 샌드위치 ELISA에서 비교되었다. 재조합 EGFR ECD 인간 Fc 융합 단백질(도 1에서 WT, WT-ECD-Fc; 또는 돌연변이, S492R-ECD-FC)이 밤새 플라스틱 표면 상에 고정되었다. 그런 후에 플레이트가 BSA를 포함하는 PBS로 차단되었다. 항-EGFR Ab 및 음성 대조 hulG Ab는 순차적으로 희석되었고 고정된 농도에서 동일한 양의 비오틴-라벨링된 패니투무마브 또는 세투시마브로 혼합되었으며, 그 혼합물은 플레이트 상에 첨가되었다. 시료는 2시간 동안 배양되었다. 플레이트가 세정되고 스트렙타비딘-겨자무과산화효소(SA-HRP) 접합이 검출로서 첨가되었다. 기질 테트라메틸 벤지딘(TMB)이 플레이트에 첨가되었고, 반응이 산으로 정지되었다. 플레이트가 2개의 파장 값(OD 450/620 nm)에서 판독되었고 WT 및 돌연변이 ECD로부터의 Ab 경합 결합 결과가 비교되었다.
셀 기반 분석에 일치해서, 생화학 결합 연구는 S492R EGFR 돌연변이가 패니투무마브가 아닌, 세투시마브에 대한 결합에 있어서 선택적으로 결함이 있다는 것을 확인했다. 비오틴-라벨링된 세투시마브에 대한 어떠한 검출도 S492R 돌연변이를 갖는 실험에서 임의의 항-EGFR Ab 농도에서 관찰되지 않았고, 그것은 어떠한 결합도 존재하지 않는다는 것을 의미한다.
이것은 역시 10㎍/ml 세투시마브 및 패니투무마브로 면역화된 후에 야생형 EGFR(wt EGFR) 및 S492R EGFR을 발현하는 NIH3T3로부터의 세포 용해물의 면역침강 분석(도 2c)의 결과로부터 결론지어졌고, 비-특정 lgG는 음의 대조로서 사용되었다. 도 2c에 도시된 바와 같이, 총 EGFR의 웨스턴 블럿 분석은 세투시마브가 S492R EGFR 돌연변이에 결합할 수 없고 그것을 침전시킬 수 없다는 것을 확인했다. 침전물의 입력(I) 및 상청액(SN) 일부는 세포 용해물에서 EGFR의 존재를 확인하도록 대조로서 사용되었다.
최종적으로, 위의 결과는 또한 유동 세포 계측법에 의해 확인되었다. 도 2d는 세투시마브 및 패니투무마브는 야생형 EGFR(wt EGFR)을 발현시키는 셀의 60%와 상호작용할 수 있었던 반면에, 패니투무마브는 S492R EGFR 돌연변이를 발현하는 셀에만 결합할 수 있었다는 것을 나타낸다. 야생형 EGFR 및 S492R EGFR 돌연변이를 과발현시키는 트립신화된 NIH3T3 셀이 1차 항체로서 세투시마브 또는 패니투무마브의 1㎍/ml로 배양되었다. 결합은 인간 lgG를 향하여 피코에리트린과 접합된 2차 항체를 사용하여 유동 세포계측법에 의해 분석되었다. 공 벡터(E)를 표현하는 NIH3T3 셀이 음의 대조로서 사용되었다. 히스토그램은 양쪽 항체에 의해 검출된 세포의 퍼센트를 나타낸다.
유동 세포계측법이 다음과 같이 수행되었다:
세포 사이클 분포 분석에 있어서, 세포는 24시간, 48시간 및 72시간 동안 세투시마브로 성장되고 처리되었다. 처리 후에, 세포가 트립신화에 의해 얻어지고, 차가운 PBS로 2회 세정되고 밤새 70% 에탄올로 고정되었다. 에탄올이 차가운 PBS로 2회 세포를 세정하는 것에 의해 제거되었다. 세포는 빛으로부터 보호된 4℃에서 적어도 48시간 동안 50㎍/ml 프로피디움 요오드화물 및 100㎍/ml의 RN아제를 포함하는 PBS로 DNA에 대해 염색되었다. 세포 사이클 분포가 FAC스칼리부르 유동 세포계측기(벡톤 딕킨슨)을 사용하여 측정되었다. EGFR에 결합하는 세투시마브 및 패니투무마브를 측정하기 위해, 세포는 트립신화에 의해 얻어졌고 PBS로 2회 세정되었다. 세포는 이모누글로불린의 비특정 Fc 결합을 차단하도록 얼음 위에 15분 동안 Fc 차단 시약(MACS®)으로 배양되었다. 세포는 세정되고 얼음 상에 30분 동안 EGFR 결합을 검출하도록 단일 클론 항체로 배양되었다. 염소 항-인간 lgGy 피코에리트린 접합(인비트로겐)이 2차 항체로서 사용되었다. EGFR 결합이 FAC스캔 유동 세포계측기(벡톤 딕킨슨)를 사용하여 분석되었다.
실시예
4.
세투시마브에
대해 얻어진(또는 2차 처리) 저항을 나타내는
결장
암
환자에서
S492R
EGFR
돌연변이의 검출
세투시마브에 대해 얻어진 저항의 기전으로서 이러한 돌연변이의 임상 적절성을 평가하기 위해, S492R EGFR 돌연변이가 세투시마브에 대한 최초 반응에 이어서 질병 진행을 겪는 전이성 결장암을 갖는 환자에서 발견될 수 있는지 여부가 검토되었다.
세투시마브 치료를 받기 전 및 치료 실패 후(치료 후 시료) 10명의 환자로부터의 쌍을 이룬 종양 시료가 분석되었다. 시료가 1차 mCRC로부터 전이된 조직인, 간 병변으로 얻어지는 경우를 제외한 모든 치료 전 시료는 1차 클론 종양으로부터 얻어졌다. 치료 후 시료는 초음파 유도로 경피 생체 검사에 의해 얻어진 간 전이로부터 유래한다. 대부분의 환자는 전이성 질병에 대한 화학 요법 중 적어도 하나의 라인을 앞서 얻었고 세투시마브는 모든 경우에 이리노테칸 또는 옥살리플라틴과 함께 투여되었다.
KRAS, BRAF 및 PIK3CA는 물론 EGFR 단백질의 세포외 도메인 영역의 돌연변이 상태가 DNA 서열 분석에 의해 평가되었다(위에 구체화된 바와 같음). EGFR 유전자 복제 개수 역시 FISH에 의해 연구되었다(실시예 1에 구체화된 바와 같음).
모든 치료전 생체 검사는 EGFR, KRAS, BRAF 및 PIK3CA에 대해 야생형이었다. 사후 세투시마브 처리된 종양 시료는 임의의 공지된 KRAS, BRAF 또는 PIK3CA 돌연변이를 품지 않았다; 그러나, S492R 돌연변이는 두 명의 환자에서 식별되었다. 특히, 한 명의 환자에서 관찰된 돌연변이는 SEQ ID NO:7의 뉴클레오티드 1720에서 뉴클레오티드 치환 A→C 변경과 연관되었고, 그것은 또한 EGFR 단백질(SEQ ID NO: 8)의 아미노산 492에서 세린 아르기닌 치환을 초래한다. 환자로부터의 정상 세포의 서열화는 S492R 돌연변이가 체세포 돌연변이었음을 나타내는, 야생형 서열만을 나타냈다. 다른 환자에서 관찰된 돌연변이는 인 비트로 연구와 동일했다.
S492R 돌연변이를 보유한 두 명의 환자 중 한 명이 1일에 세투시마브(400 mg/m2 최초 용량 그런 후에 250 mg/m2/주로 이어짐) 플러스 옥살리플라틴 85 mg/m2, 1일과 2일에 22시간 동안 플러스 류코보린 200 mg/m2 및 400 mg/m2 볼러스로서 이어서 600 mg/m2 주입에 의해 플루러유러실로 치료되었다. 치료를 시작한 지 3개월 후, 계산된 단층촬영(CT) 스캔은 고형 종양(RECIST)에서 반응 평가 기준에 따라 부분 반응을 나타냈다(아이젠하우어 등, "고형 종양에서 새로운 반응 평가 기준: 개정된 RECIST 가이드라인(버전 1.1)", 유럽 암 저널 2009, 45(2)권:228-247). 그러나 치료 10개월 후, 간 병변은 명백한 진행을 나타냈고 새로운 간 병변이 나타났다. 세투시마브 치료는 중단되었고 기존 간 병변으로부터의 생체 검사가 그런 후에 분자 분석을 위해 얻어졌고, S492R EGFR 돌연변이가 나타났다. 환자가 그런 후에 이리노테칸 기반 화학 요법으로 치료되었지만 반응하지 않았다. 2주 마다 단일 제제 패니투무마브 6mg/Kg으로의 치료가 그런 후에 시작되었고, 치료 2달 후, CT 스캔은 50%보다 더 큰 모든 간 병변에서 감소를 나타냈다.
출원에서 인용된 참조문헌
멘델손 제이, 바셀가 제이 등, "암에서 표적으로 하는 상피세포 성장 인자 수용체". 종양학 세미나-2006, 33권, 369-38쪽(Mendelsohn J, Baselga J et al., "Epidermal growth factor receptor targeting in cancer". Semin Oncol - 2006, Vol. 33, pp.: 369-38)
곤칼브스 등 "EGFR 세포외 도메인의 다형성은 세투시마브-기반 치료를 수용하는 전이성 결장암 대상에서 무진행 생존과 연관된다", BMC 암-2008, 8권, 169쪽(Gongalves et al., "A polymorphism of the EGFR extracellular domain is associated with progression free-survival in metastasic colorectal cancer pateints receiving cetuximab-based treatment", BMC Cancer 2008, Vol 8:169.)
아이젠하우어 등, "고형 종양에서 새로운 반응 평가 기준: 개정된 RECIST 가이드라인(버전 1.1)", 유럽 암 저널 2009, 45(2)권:228-247(Eisenhauer et al., "New response evaluation criteria in solid tumours: revised RECIST guideline (version 1 .1 )", Eur J Cancer 2009. Vol. 45(2):228-247.)
드 루크 등, "화학요법-불응성 전이 결장암에서 세투시마브 플러스 화학요법의 효험에 대한 KRAS, BRAF, NRAS, 및 PIK3CA 돌연변이의 효과: 회고 컨소시엄 분석", 란셋 종양학회지-2010, 11권, 753-762쪽(De Roock et al., "Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastasic colorectal cancer: a retrospective consortium analysis", Lancet Oncol - 2010, Vol. 11 , pp. :753-762)
루파키스 등의 문헌, "전이성 결장암을 갖는 환자에서 세투시마브 플러스 이리노테칸의 혜택의 예측에서 1차 종양과 전이 대한 PTEN 발현 및 KRAS 돌연변이", 임상종양학회지-2009, 27권, 2622-2629쪽(Loupakis et al., "PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit of cetuximab plus irinotecan for patients with metastasic colorectal cancer", J Clin Oncol - 2009, Vol. 27, pp.:2622-2629.)
카라페티스 등, "발전적 결장 암에서 세투시마브로부터의 K-ras 돌연변이 및 혜택", 뉴 잉글랜드 의학 저널-2008, 359권, 1757-1765쪽(Karapetis et al., "K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer", The New England Journal of Medicine - 2008, Vol. 359, pp.: 1757-1765.)
몽타구에트 등, "미토겐-활성화된 단백질 키나아제 포스파타아제-1(MKP-1)은 전이성 결장암 환자에서 항-상피세포 성장 인자 수용체(EGFR) 항체 세투시마브에 대한 반응을 손상시킨다", 영국 암 저널-2010, 102권, 1137-1144쪽(Montagut et al., "Mitogen-activated protein kinase phosphatase-1 (MKP-1 ) impairs the response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab in metastasic colorectal cancer patients", Br . J Cancer -2010, Vol. 102, pp.: 1137-1144.)
아마도 등, "야생형 KRAS는 전이성 결장암을 갖는 환자에서 패니투무마브 효험에 대해 요구된다", 미국 임상종양학회지-2008, 28권, 1626-1634쪽(Amado et al., "Wild-type KRAS is required for panitumumab efficacy in patients with metastasic colorectal cancer", J. Clin Oncol - 2008, Vol. 28, pp.: 1626-1634)
파오 등, "제피니티브 또는 에를로티니브에 대해 폐 선암의 얻어진 저항은 EGFR 키나아제 도메인에서 제 2 돌연변이와 연관된다", 국립과학도서관 의학지 2005; 2:e73(Pao et al., "Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain", PloS Med 2005; 2:e73)
린치 티제이 등, "제피티니브에 대한 비소세포 폐암의 상피세포 성장 인자 수용체 기저 반응성에서 돌연변이를 활성화", 뉴 잉글랜드 의학저널-2004, 350권, 2129-2139쪽(Lynch TJ et al., "Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib", N Engl J Med-2004, Vol. 350, pp:2129-2139.)
파에즈 제이지 등, "폐암에서 EGFR 돌연변이: 제피티니브 치료에 대한 임상 반응과의 상관관계", 사이언스-2004, 304권, 1497-500쪽(Paez JG et al., "EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy", Science-2004, Vol. 304, pp. :1497-500.)
파오 더블유 등, "EGF 수용체 유전자 돌연변이는 "흡연 미경험자"로부터의 폐암에서 공통적이고 제피티니브 및 에를로티니브에 대한 종양의 민감성과 연관된다", 미국국립과학원회보-2004, 101권, 13306-13311쪽(Pao W et al., "EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib". Proc Natl Acad Sci U S A-2004, Vol. 101 , pp.:13306-13311)
SEQUENCE LISTING
<110> Fundaci?Institut Mar d'Investigacions M?iques (FIMIM)
<120> Mutations in the epidermal growth factor receptor gene
<130> P2029PC00
<150> EP11382270.4
<151> 2011-08-03
<160> 17
<170> PatentIn version 3.5
<210> 1
<211> 9
<212> PRT
<213> Homo sapiens
<400> 1
Thr Lys Ile Ile Arg Asn Arg Gly Glu
1 5
<210> 2
<211> 25
<212> DNA
<213> Homo sapiens
<400> 2
ccaaaattat aagaaacaga ggtga 25
<210> 3
<211> 19
<212> DNA
<213> Artificial
<220>
<223> Reverse primer for amplification of fragment of human EGFR gene
<400> 3
gggacctccg gtcagaaaa 19
<210> 4
<211> 22
<212> DNA
<213> Artificial
<220>
<223> Direct primer for fragment amplification of human EGFR gene
<400> 4
cggtgactta ctgcagctgt tt 22
<210> 5
<211> 20
<212> DNA
<213> Artificial
<220>
<223> Probe for detection of mutation in EGFR gene
<400> 5
cacctctgtt tcttataatt 20
<210> 6
<211> 18
<212> DNA
<213> Artificial
<220>
<223> Probe for detection of wild-type EGFR gene
<400> 6
cacctctgtt gcttataa 18
<210> 7
<211> 5616
<212> DNA
<213> Homo sapiens
<400> 7
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg 60
gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac 120
aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc 180
gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga 240
gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc 300
tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc 360
acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt 420
gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc 480
ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga 540
attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc 600
ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga 660
aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac 720
gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg 780
gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc 840
tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag 900
tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca 960
ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc 1020
acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat 1080
gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat 1140
tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg 1200
gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac 1260
ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac 1320
ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt 1380
gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta 1440
aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat 1500
gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt 1560
gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat 1620
ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa 1680
aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc 1740
tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg 1800
gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag 1860
tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc 1920
cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac 1980
tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga 2040
gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac 2100
ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg 2160
aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg 2220
gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg 2280
ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct 2340
cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg 2400
ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt 2460
aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa 2520
atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg 2580
ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc 2640
ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt 2700
gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg 2760
gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg 2820
gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc 2880
aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg 2940
agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc 3000
cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata 3060
tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc 3120
ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac 3180
cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac 3240
cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc 3300
ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg 3360
agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt 3420
cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact 3480
gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc 3540
aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg 3600
cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat 3660
ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc 3720
cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc 3780
aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta 3840
agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc 3900
ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac 3960
agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta 4020
gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac 4080
tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat 4140
ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg 4200
ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag 4260
gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag 4320
gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt 4380
ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta 4440
ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga 4500
agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta 4560
cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt 4620
cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag 4680
caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc 4740
atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt 4800
tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg 4860
catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca 4920
accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc 4980
aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc 5040
cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag 5100
ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg 5160
aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc 5220
agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg 5280
gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg 5340
actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc 5400
catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca 5460
gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca 5520
gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa 5580
ctatattcat ttccactcta aaaaaaaaaa aaaaaa 5616
<210> 8
<211> 1210
<212> PRT
<213> Homo sapiens
<400> 8
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
1 5 10 15
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
20 25 30
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
35 40 45
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
50 55 60
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65 70 75 80
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
85 90 95
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
100 105 110
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
115 120 125
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
130 135 140
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145 150 155 160
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
165 170 175
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
180 185 190
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
195 200 205
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
210 215 220
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225 230 235 240
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
245 250 255
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
260 265 270
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
275 280 285
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
290 295 300
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305 310 315 320
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
325 330 335
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
340 345 350
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
355 360 365
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
370 375 380
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385 390 395 400
Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
405 410 415
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln
420 425 430
His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu
435 440 445
Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser
450 455 460
Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465 470 475 480
Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu
485 490 495
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro
500 505 510
Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn
515 520 525
Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
530 535 540
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro
545 550 555 560
Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro
565 570 575
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val
580 585 590
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
595 600 605
Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys
610 615 620
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly
625 630 635 640
Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu
645 650 655
Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His
660 665 670
Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu
675 680 685
Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu
690 695 700
Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser
705 710 715 720
Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu
725 730 735
Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser
740 745 750
Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser
755 760 765
Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser
770 775 780
Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp
785 790 795 800
Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn
805 810 815
Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg
820 825 830
Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro
835 840 845
Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala
850 855 860
Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp
865 870 875 880
Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp
885 890 895
Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser
900 905 910
Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu
915 920 925
Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr
930 935 940
Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys
945 950 955 960
Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln
965 970 975
Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro
980 985 990
Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp
995 1000 1005
Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe
1010 1015 1020
Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu
1025 1030 1035
Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn
1040 1045 1050
Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg
1055 1060 1065
Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp
1070 1075 1080
Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro
1085 1090 1095
Lys Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln
1100 1105 1110
Pro Leu Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro
1115 1120 1125
His Ser Thr Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln
1130 1135 1140
Pro Thr Cys Val Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala
1145 1150 1155
Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln
1160 1165 1170
Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe Lys
1175 1180 1185
Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln
1190 1195 1200
Ser Ser Glu Phe Ile Gly Ala
1205 1210
<210> 9
<211> 195307
<212> DNA
<213> Homo sapiens
<400> 9
attagccagg tatggtgatg catgcctgta gtcagagcta ctcaggaggc taaggtggga 60
ggatcacctg agcctgggaa gttgaggttg cagtgagcca aggtcacgcc actgcactct 120
ggattgggca acagagccag accctgtctc aaaaaaaaga aaaattccat ggctctgctt 180
acattatcca tctgatctta catgttgcct attttttcca ttaaaactcc tagcctatta 240
atcatagttt ttttataatt aatactccga tgtgataatg tcttagtcca attactgtgg 300
ttataacaga atgccacaaa ctgggtgatt tataaacaaa agaagctgat ttaggctgat 360
ttagaggctg gggagtccaa gagcttggtg ctagcatctg atgagtgtct tcttgcttca 420
tcataacatg ggagagggca tcacgtgtga agagagctta ctcttataac atagccactc 480
ccacaagaat taacccaccg ccatgagagc catgtgaatt cattcatgag gacagcgggt 540
taagtttcca atatatggac ttttcgggga cacattcaaa ccacagcagt tagttgtaac 600
gttcgtgtca tgtctcattc tggttctgat gcttgtgcag tctcttcaaa ctgcgtcttt 660
gccttttagt gtgccttgca atgtggaaat gatatactgg gtaagaggag ctgtagtaaa 720
gaggcttcta gtgacgtagt gacaagctgt ggggagaggg agtgttgcac agtcctgccg 780
catgtcacag tcttccagtg agcctgtgtc cctggactgt gaacttcatg cttgcttctc 840
agcttcccca gccccttaga tggtacagaa ctgttggagg ggggtggagt tgtatatttc 900
ccttgctctg ggtaggtcac cctctgataa aacaccaggt taggcctctg gtgaaataat 960
ttctcctgag ggcagacctt ctattaataa tagaatgttc caacctattt caaaatggtt 1020
cctcttctcc ttccactgcc agaagcataa tgagattttc cccctaatat tcgtggtaag 1080
gacctagcag agctccagga ggtaacactc tcaagtgtct catactaccc tgcaccatga 1140
ctgggctctg ctggagttct taatttgcag aactgcccac actgagcctc ccgcaatttc 1200
tcaattacag ggcaaacttt cccagccggc actgggtcct tggaggtttc tgtctgctgg 1260
tttcttcctc tggaggttgt gcttctgtgt ttgcctgtct ctccaatttg gggggcagtg 1320
gtttgcccaa tgacctcaat tctctgaaag agctaagaag aggtgttaat ttttcggttt 1380
gctcagcttt ctacttgttg ctagaatgga gcgccaatag tgcctcctat agtgacatgt 1440
aaccctcaac tctagagatg atgaagcata ctaatgacaa aggagaaatg cttcagcagt 1500
tttctgtcag cacattaccc cttgaaaaag ctgcttcttc cacattctgc aagagatggg 1560
tctcaactca gagctcaagg caaatgactt ccttcaagga gaaggaataa acagtctcag 1620
aaaccatgaa agcctgcccc caggagtgtc cctgaacctc agcaggggcc acacttacct 1680
tgcagaaata ggtgaggcat gctcctggta caaaatccca atggtacaga aggacaaatt 1740
gaaaaacaag tctccctcta aacccctgac cccgagctac ctagttctcc tccctagagg 1800
caaagctgtt accagattct tgtatctcct taacatatat ccttagaaga gctgtcaagt 1860
gaacacatgt ttaagtgaaa acctatttta gaagtgcatt ttcttaagga actttagggt 1920
tggaaggaac ctgtgtcagt ccttaattca caacctccat tagtacttat tgttcttgca 1980
caaaaatctt tctcaaaaaa gccctttcca ctctgacata gcttattcta cttttactta 2040
gctccaataa cttataaaac atatttttga aagtctaaaa tctgccacta tgtttttttt 2100
tcctaatcaa tctttacttt gacctctaag ccagagaaaa caggtggtca aatgcctttt 2160
gcctaagatg gaacttagaa tatttgaaga cctcagatct tcaccctgcc aaataacgtg 2220
tttctcctcc cctttcacag agcatttggt tttaggaaat tcagagccac attccttata 2280
gacaagacta aactcttatt caacatactc agaaacttct tctaagagga taaccactca 2340
tcagaggaaa aaagtttctc atgtacagct ggcaaaggga tggaaccatc tgtgttatta 2400
aaattgacag acgcttatga gatttattaa gggaaatact agagtcttag tacatacttg 2460
ctaatatagc atacatgaag gctttatcta taattttttt ggccaagcag aaattttggt 2520
attactcacc ctaacaaatt tccaagacat tatgaaatag aattttaggt cctgacatca 2580
ccatttgtct caggttttga agcgttgctg gacaagaggg gtaaaacacg gctctgcctt 2640
ggattcaaag ttggcctctc atactagcaa gtataccttg gtatcctggt cacttctccc 2700
ggccacagca tcacattgct ataaaaggca gatacaagta ttaaccagct cacaggttat 2760
cagataagct tagtctgacc aatgcttaac acagcaactg ggccactatt gtcattcctg 2820
tggtggtggc acacacaccc agcctctgtc cgggccatgg tctaggacca ccctccacag 2880
aggctgtgag ctagagccct aactgtgcag ggccctaact atgccaggct acttatctct 2940
cttaagagga cttcattagt gcctgctcgg ccatacagtt ttttacttac caagtaacac 3000
agttatcagc acactccagg tactagccaa ggactacaaa atcaacgtga atgtcagctt 3060
ttgtatcaaa agctcaaagg agaaactcaa actttacata gatgtcccat gaagatgttc 3120
agcaaaccca ttcttctctg ttccctggaa tccatcccag tattgtgcta tgtgtgtgtc 3180
tagtaattct ttacaaaaag ctctgtttct tgtgatgcta tcagatcaca ttgaagaata 3240
tacaagccgt actatgaagg ctgttgtctc atatagtcct aacgtagtga gaactgatgt 3300
tcttacatgc tgtctttttg ggcactcaaa gaaattcctg tacagtctta caaatcagtt 3360
gtagcttaaa ttgatttgtg ttgtgacttg tacacacagg tcacattccc ttgacagaaa 3420
atatagttta aaaccaaatt tgcagccctt gttaagtgaa tgcacaggac tttattgtat 3480
tcaggtcttt tattgtaaga ctcactcctg tcttcatttt atgttccact gttgtgcttc 3540
ccatttgcct ttctctagtt ttgttttctg tgtttctacg gactgctctc agcccaggtg 3600
tgcaggaagc acacacatgc ctgcagagcc ttcatggcct ctgcattcag ggcatgactt 3660
caacgcacag tggctgtact gatttgttaa aacaaaggaa cagattactt ctcctaattc 3720
acagggaagt tccaggttgt gcgggcagtg agcagacctg tgtctgtctg cgcttgccct 3780
ggtgaaaaac cccaccgttc aggctgcagg gtgcgagacc caggcacaaa cattttgctg 3840
gatgaggagg aaagatgtaa ggttgctccc cttcagagac agcaaagggc aggtctgtag 3900
cttcacttac ttcaggattg tgatttttga cagagccgag agatcagggt tgttgaacca 3960
ggcctgaagg tcctagtgaa tctcgtgaag agaggagggg tctggctgta acatggacct 4020
agaggacatt tttactgcag gagaaggaac agtggggatg gggtggactt gccaaaggaa 4080
tatagctcaa gttcctgcag cccaaaaaag ctcagtttct tttggccaaa gcttccgcga 4140
gtttccctgg catttctcct gcgggagcta caggggcagt gggacactta gcctctctaa 4200
aagcacctcc acggctgttt gtgtcaagcc tttattccaa gagcttcact tttgcgaagt 4260
aatgtgcttc acacattggc ttcaaagtac ccatggctgg ttgcaataaa cattaaggag 4320
gcctgtctct gcacccggag ttgggtgccc tcatttcaga tgatttcgag ggtgcttgac 4380
aagatctgaa ggaccctcgg actttagagc accacctcgg acgcctggca cccctgccgc 4440
gcgggcacgg cgacctcctc agctgccagg ccagcctctg atccccgaga gggtcccgta 4500
gtgctgcagg ggaggtgggg acccgaataa aggagcagtt tccccgtcgg tgccattatc 4560
cgacgctggc tctaaggctc ggccagtctg tctaaagctg gtacaagttt gctttgtaaa 4620
acaaaagaag ggaaaggggg aaggggaccc tggcacagat ttggctcgac ctggacatag 4680
gctgggcctg caagtccgcg gggaccgggt ccagaggggc agtgctggga acgcccctct 4740
cggaaattaa ctcctcaggg cacccgctcc cctcccatgc gccgccccac tcccgccgga 4800
gactaggtcc cgcgggggcc accgctgtcc accgcctccg gcggccgctg gccttgggtc 4860
cccgctgctg gttctcctcc ctcctcctcg cattctcctc ctcctctgct cctcccgatc 4920
cctcctccgc cgcctggtcc ctcctcctcc cgccctgcct ccccgcgcct cggcccgcgc 4980
gagctagacg tccgggcagc ccccggcgca gcgcggccgc agcagcctcc gccccccgca 5040
cggtgtgagc gcccgacgcg gccgaggcgg ccggagtccc gagctagccc cggcggccgc 5100
cgccgcccag accggacgac aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc 5160
gccaacgcca caaccaccgc gcacggcccc ctgactccgt ccagtattga tcgggagagc 5220
cggagcgagc tcttcgggga gcagcgatgc gaccctccgg gacggccggg gcagcgctcc 5280
tggcgctgct ggctgcgctc tgcccggcga gtcgggctct ggaggaaaag aaaggtaagg 5340
gcgtgtctcg ccggctcccg cgccgccccc ggatcgcgcc ccggaccccg cagcccgccc 5400
aaccgcgcac cggcgcaccg gctcggcgcc cgcgcccccg cccgtccttt cctgtttcct 5460
tgagatcagc tgcgccgccg accgggaccg cgggaggaac gggacgtttc gttcttcggc 5520
cgggagagtc tggggcgggc ggaggaggag acgcgtggga caccgggctg caggccaggc 5580
ggggaacggc cgccgggacc tccggcgccc cgaaccgctc ccaactttct tccctcactt 5640
tccccgccca gctgcgcagg atcggcgtca gtgggcgaaa gccgggtgct ggtgggcgcc 5700
tggggccggg gtcccgcacg tgcgccccgc gctgtcttcc cagggcgcga cggggtcctg 5760
gcgcgcaccc gaggggcggg cgctgcccac ccgccgagac tgcactgttt agggaagctg 5820
aggaaggaac ccaaaaatac agcctcccct cggaccccgc gggacaggcg gctttctgag 5880
aggacctccc cgcctccgcc ctccgcgcag gtctcaaact gaagccggcg cccgccagcc 5940
tggccccggc ccctctccag gtccccgcga tcctcgttcc ccagtgtgga gtcgcagcct 6000
cgacctggga gctgggagaa ctcgtctacc accacctgcg gctcccgggg aggggtggtg 6060
ctggcggcgg ttagtttcct cgttggcaaa aggcaggtgg ggtccgaccc gccccttggg 6120
cgcagacccc ggccgctcgc ctcgcccggt gcgccctcgt cttgcctatc caagagtgcc 6180
ccccacctcc cggggacccc agctccctcc tgggcgcccg cgccgaaagc cccaggctct 6240
ccttcgatgg ccgcctcgcg gagacgtccg ggtctgctcc acctgcagcc cttcggtcgc 6300
gcctgggctt cgcggtggag cgggacgcgg ctgtccggcc actgcagggg gggatcgcgg 6360
gactcttgag cggaagcccc ggaagcagag ctcatcctgg ccaacaccat ggtgtttcaa 6420
aatggggctc acagcaaact tctcctcaaa acccggagac tttctttctt ggatgtctct 6480
ttttgctgtt tgaagaattt gagccaacca aaatattaaa cctgtcttac acacacacac 6540
acacacacac acacacacac accggattgc tgtccctggt tcaagtgtgc caagtgtgca 6600
gacagaacat gagcgagtct ggcttcgtga ctaccgacca taaacccact tgacagggga 6660
aacatgcctt ggaaggttta attgcacaat tccaaccttg agctgcgcgg gttccaagag 6720
ccaggcccgt acttgctgtt gatgtcattg gcttggggag ttggggtttg gtgcccagcg 6780
cggtcgttgg gggaggggca aggcatagaa cagtggttcc cagaccttgc tgcacattgg 6840
aattacctgg gattaaaaaa aaaaaaatca aaacaaaaac cagtgtctgg ctcccgcccc 6900
cagacattct gatttaattg gcatggggca agacctggac ttgggatttt ttttaatgct 6960
cttcatgtga tctgttgggc agccagattt ggggatcact agacggaaga aggattgtta 7020
aagtctccgg agatgttact tgccaatgct aagagctctt tgaggacatc tggaattgtt 7080
acaatattgc caaatatagg aaagagggaa aaggtagagt gtgattccaa taataaagga 7140
ttccgctttt cattgaagga actggtggaa aggtttcttc tctgctgagc ctgcaggccc 7200
gtcctgcctg cctggggtgc ccgggagacg cgggcctgct ccggagactg ctgactgccg 7260
gtcctgttag tcaggtgtca gccctgtctc tgccgaagag actcttctct ttattttaaa 7320
ttaaaccctc agagcaccac caaagcatca cttttctccc tccattggtg ttctcattct 7380
ttgatgttac ttgtttgaac accactatta gtagttggag atttgttcct gagaaaaata 7440
taaataccac ttaatttgcc tgtttgtccc gcattcactc aaaacagaat gctcctgaag 7500
acaagagaga gagtaggaga acagacgcta ttccattaca gtaacataaa agactggatt 7560
ttcaggggca aattattaaa ataggagatg agctctttta acagaaattt gtttaaggcc 7620
tgtgtctatc aaattcagtg gattttattc aagatgcact ttgtttagtg ggagttttgt 7680
ttggttctgg gacatgctaa cttctagact tgctgctctt agaggtaatg actgccagac 7740
accatttcat gagtcctaat ccccacatta agcataagag gtgcacactc tcctcctatg 7800
ggggaaactg aggtacgaag aactaaagtg actttcccac agctggtggg aggcagacgg 7860
gaaattcaca ccaggggctt ccaactccag atccctctct caacttccaa actccactgc 7920
cttgtccgag ttctggtttc aggagatcca aatcaggtgt gtgcaaatgt ctaatgtcag 7980
agctggcaag gggaaagggc ccagggagcc ggctcatgac gatgagcctg tctgaagctt 8040
caacgcgggc tgtccggcag tctgcattcc tgccgagttc ctcagccctc tgttgggtca 8100
ccttccatag aggcagctta gtcctcagtt cagtgagcat ggagtggaga ctgcttgagg 8160
ggtgctgagc aaagccctgc ctcttacagg atgaaggtgc tctccagaag ggacactgga 8220
aagtattcca aggcgagtcg aattcccaac tgagggagct ttgtggaaat aagcccgccc 8280
agccccactt ctggagacgt tcccattcag taggtccgag ctgtcttaaa gagaaaccaa 8340
agtggggata ttaatggtat ccaaagtgag atctacccca ccctccctcc tcaaaggagg 8400
tcagatcaag aaagcccaag cccggcctgg caattgggac ctttcttctc actccagccc 8460
agggtgaagg tggacaagtc actttgaccc ttcaggcttc tgagctgttg tttctgaatt 8520
cagtgaatat ttactgagtg catagaatat gctagatatt ctgggctaaa ggttgaaggg 8580
ggggtgagtt ttaagggttt ctgctcttgc ttccagattg ctttcaaatc tggaaaggac 8640
accagtggtt tgtgtgttag acccacactg ccgtagcaca gaatacaaga aactggctga 8700
gagctccaat aggcttttaa cagtaatttc tggcttcacg tatttagttt cataactcat 8760
gatttttcaa aaacttctgg tttgaagaca ccgattgccg aaagtccatt gtgctgcata 8820
attacacttg gtccacgtga cagcactaac atgttctgaa atgtttttag aagtagtctc 8880
agcaaagatg aaggattcct ccctgtttga aaagaaaata ttctttgttt tttctttgat 8940
ctaagctcta agactagcag ctagcatctg aaactttttt gacgagagtg acaaaccaac 9000
tctaatatta aaggcaattg atgattatgg gcactgaagg gaaggtaacc ccaggctggt 9060
gccccggaat agggatgggt cacaatgttg aggacatttc gcctgttgca gaacccacct 9120
gcaacacagt gtggcccttg ccatgtgact tgtgtgtgtg cctgtgtgtc tgtgtgtgcg 9180
tgttttaatt ttgacttcat aagtactcta gttatgagct tatttaacat tgggttttac 9240
taataggggt atgtgttgag aaaatttcaa agttttagaa tatggttcac ccacatgttg 9300
cttccctgta aatataattt ttaaaaccag attctgggcc gggcatggtg gctcacctct 9360
ataatcccaa aacgttggga ggccgaggca ggcgaatcat gaagccagga gtttgagacc 9420
aggctgacca acacggtgaa acccagtctc tactaaaaat acaaaaaaaa ttagctgggc 9480
gtggtggcag gtgcctgtaa tcccagctac tcaggaggct gaggcaggag aattgcttga 9540
acccaggagg cagaggttgc agtgagccaa gatcgcacca ttgcactcca gcccgcgcga 9600
cagtgtgaga ctccatctca aaaaaaaaaa aaaaaaaaca gattctgttc ctcagatcca 9660
ttccattttt gttttccttt atcacttatg gacatttgaa attatggtaa taaacattgt 9720
tagtctcagt taattattac tggtttattc ttgaaccact aatccataga gaatagagtg 9780
taaatcttaa cttgttcctg taggccatcc ccattaaaca tcatagtgtt ttctcattcg 9840
ttctttttcg ttttcctcct acaggaatga attttctaag aaaattccag cagttggctc 9900
tttggacgac atctctagat tgtcctccat tgggcccata ggcacaagct ggccagtttg 9960
aatttgggca agaatccagg cattggaact tattcaaata actagtttgc ctgtaatttt 10020
cactttttca gagtcatctg ataaagcttt cttgctacac atttagatag atacactcaa 10080
tccagttgtc tagaaagttc cctgagccag ctgggagcag gaggggtagt tggggccagg 10140
aatattgggg gtgtgtttac tgagccccta gaaagtaagt gctagatttg acatttcaat 10200
ccctgaaggc cctgaagttc agtatcaaat gactggtcct gtggactgag catctgtgaa 10260
ttgcatatgc ttagagtaaa ttttactcct accagtttca gcagcttgct ttagcaagca 10320
gtatggaaac actaacatgg gggagtagaa tttctctctc tgatccaagt tttatctcat 10380
tctggtgggt tttcaaggag agactcggag tccaagtgtc ctttctgaat atatctggaa 10440
cttctcatta acaaaagact caagttataa tttaggggac aaggcaccca atgagaatgc 10500
cttgcaggca gccctaagta cacctgcaat tacaccatta ctagcgcggc agcacacatg 10560
gccctgactt agtttaaata attacgtaag tcaaccatga ttgtttgccc tttgcataga 10620
agggcaagta ttggtacctg ttacaactta ggcttttttt tctttatgtt tgagccatga 10680
tgagtgattt acactgttgc atccatatgt tgagatgtaa gaataaatta gacttggtaa 10740
ttgcccttaa gtgtctggaa gtcaactggg gaaagagagc tagagataat aagtgtgaaa 10800
caatgtcaca gaatcaatga cggaactctt cccaggacaa aggatgactt ttgagttcag 10860
tctttgcctt taattctaca tggggaggag agcacgttta gccacaaatg gaagggatta 10920
ctcatttgag ctatttggtt atatgattat ttccccagag aataggatgt gcagggcatt 10980
acacaagcag tgccaatagc agcaaagttc ttgagagtgc tagtaattca aatggcagga 11040
agagaaggaa taaatggtaa ggctacctac agttcacaga gagctccatc ctcactgtgg 11100
ctttggattt tgtcctgtgt gaaagagaag tgactgtgaa ctgacatgct gtgtttggtg 11160
ttttagaaag atggctgcag cagcggtttg gggaatggac tgcaggagtg gcattggaaa 11220
caggaaggtt catgactatt gccagagaca gaggatgaag caggagcaag gaagattcag 11280
gacaggggac tccggggctg atcaggaggc agaactggtt gataagtata tgtagcagca 11340
taagaaagaa agaatcccag attgacaccc aggcttctca cttggaagcc tggatagata 11400
ctgaatgcaa tcacaaaggc tgggaagtca atgggactgc agggaaggga agggaaggga 11460
ggagaagagg aagggcagga gggtccaata tcaatattca gcttttagat gtgttgagct 11520
tgaagtgctc agatggagaa gtccaggagg cagtagaata cggtggtcca gagcacagga 11580
gagcaatgtg gcttgagttg tcatttgctc acatatttcc gtgtcagtta cttgtcttag 11640
atcacagaac aagttctcct ctcacagttt cctggctcca cctgtctcat gctcaccgtc 11700
agcatcgaaa ttgagccaca ccaggggttc tggataccag cttctctcta ggtgaggctg 11760
ctatagtcag cagctgatta gttgcagtta tcagcaactg gtaatataat atattgtgca 11820
tataagtgta ccagaagtca tgtttatata ttgctgcaaa tactcggaat ggggatctct 11880
tgttccctgc ttaagaccac atcacattac ttggttttgt acgctagtgg ctgaaccaaa 11940
aaaagtagga gatgattttt tttctttttt cttaaagcag tagcttttga accttgacca 12000
tgctttctaa ccagctgagg ggcttttgaa aaagagggtg ccttactgtg ccccagacca 12060
ggacaatcag tatttctggg gaatggagcc tggcacacac acatttctta aagctccctt 12120
ggcaattctg aggagtggat tacatgttgt atgtagctcg taacgaaaga aatcttgtct 12180
ttgctctcag acccccattt cttactcatc tcatgagctc cttcgagatc cagaaacagt 12240
tgcatatttc attagtaaat cagttccaga gtcacatttt atttcacaag ttagtccatt 12300
aaaagtttcc tgcagtgagg aaatagccag aaagaacact ccacccctcc tcctttttat 12360
aactataggg tctggctcga cagagcagga gcatcgccat cttggacaag cccctcattc 12420
taaagttcac cttaataaaa aactgcctaa attcaaactg catcagccta atggctaagg 12480
tcagcatgac cataaaccac aaataacatc tccaaccgga aacattcgaa actcctcctc 12540
gaccagagac atgctagtcc cgagataacc cccctccagc agggaagatg ccagtctcgg 12600
gataacctct ctctggccgg aaagatgcct gccccaagat aaacttgcct cctcccagag 12660
atattccaac cctgccataa aacttctccc tcaaacagga acattccaaa attctgataa 12720
tctccctcac cctaaaacca atatatactc ctagtctgta agagaaagcg ctcttgacca 12780
aaattcacca ggagtgcctc ccaggtttta actaaagaaa acctctcttt aactgccaaa 12840
aaaaaaaagg gaaaaaaaaa agctttctgc agtggctttc agcgggccca gcatggcagc 12900
agcacctgag aacctgttgg agatgcacac tcttggaccc caccctggcc tctgagtaag 12960
acactggaag ggcaggcccc ggtctgtgca cacaagtcct cagggagatt ctgactgatg 13020
catgccagat tttgagaact gctgatatac tccaggcaca tcgcatgctg ggatctagat 13080
acaccaaggg aacaaaataa ctgcacttgt cctctgagga ccgacttacc ttttggaagg 13140
gctgagaaag agagacacat acaagatcac tccctgtaat gcaatgtttt ataacagatg 13200
tgatttggga tttcagtggg agcccaaaag agggactgac taattcagcc tctgtgacaa 13260
ggggagtttc tcagaaacag aatgcttagc tgggcctcca ggcacaggga caggaatgag 13320
gaaatacttg taggccctgt gctccttcag caaaaccctc agtttcttgt tatttttata 13380
aatgcaaaca tcttattaaa gtagatgcta aggcattaga atttcctgct ttatttttct 13440
aaatgaccat gaggaaacct ggaatgtcaa agataaagtg caacacattc tgcatttaaa 13500
aattaaaatg atccttttta aaagtagcaa ccagatgtga aaaattggac tggagtccag 13560
gttatagttg atagctttaa ctttctcccc aacagcaaca gcacaatttt ccctaaaatg 13620
tgttatgaat aagtaaaatg actacttcac atcctttaac tcttcctaca gaaatctaag 13680
agagaaatga aacaaaagtt tgcacagttc tagacacgat aaatacatgt gaaatcacac 13740
aactcagaaa atgtccctta aattaattga gccattggta cttgtgaatt agaagagaca 13800
tctatgttct gatccactgt tgaaagctgt acaatgttac ctatttattt gcagacatcc 13860
tttggaaaca aataggtaga tttgcaacaa ataaagagtg gagtacagct gctgacatta 13920
ccttgtatat tcatgccttt atgtaaaaaa aaaaaaaaaa atatatatat atatatatat 13980
atatatatat atatacacac acacacacat atggaggtaa agaccactgc ttgctttgca 14040
gttgttttaa gagcattcat gaaggatttt attttataag cagaaatgtg atatctgacg 14100
attttaccac tacatgcttg caggccagtg cacagcagat gacgtcatga ttgttttagc 14160
agtcctatcg ttttacttat gatgtcatta caaccctttg ctaaaatttc tttcctttac 14220
tccaggtttt ggataaaatt gatgcattgc acatagtctc tctgataaga caaactggca 14280
tttgtatgtg aaaaactgtg catgttttag tgtctctgct gatactcaaa ttatccatta 14340
ttttagtgct ggaataaaaa caaaccactt agtgaatttg tgcaggtcct taaggacagg 14400
caaaggtgtc ctgagatttt ctgatcattg tataccaaat tttagaaact ttttcaaaaa 14460
cattttttta atttcaaaaa cctggttttg tttatttacc agcaatcatt gaatacctga 14520
aagctttcag gagattttat tacaatggtt tctattcact tacaaaatta tctcctagtt 14580
cattctcata cactgtaagc cattgtaaat gcttcaaatt gtgccgaaca agataaacta 14640
gacaaactat tttaagtttg ttctagtgct aacttgcaag atctaatggc tccaactaga 14700
tttttaaaat aaagtatatt ttaatatatt attagaaagt taagcaatta tctgtttata 14760
ggtaacaaaa accctggaac cccaatgtca gatgtcatcc acttttgatt aagtccaaac 14820
atatgacaga taaacaaaag atggttggct gggctcagtg gctcatgcct gtaatctcag 14880
cactttcaga ggccgaggcg ggcggatcac aaggtcagga gtttgagact tgcctgacca 14940
acatggtgaa acccgcctct actaaaaata caaaaaaaac agctgggtgc ggtggcacgt 15000
gcctgtagtc ccagctactc aggaggctga ggcaggagaa tcacttaaac ctggaaggca 15060
ggggttgcag tgagctgaga tcacaccact acactccagc ctaggcgaca gagcaagact 15120
cagtcaaaaa acaaaaaaaa agtggtcatt ggagaattat tgtgtcacct gttgtttttt 15180
aatgtactaa ttttgagagg cttttaaata gagtgcacta tagaactttt tcttggcttc 15240
aatttgctac aatgttaata gagaatcaga aaccttatcc ttatagatgt ttcttgattt 15300
ttttaatttc tggtgacatt tatgagtgag aatagtgtat tgccctgttt tctttcttac 15360
tcccctttct tcttccttcc ttgctttctt tcttcttccc ttccttcttt ctcttcctcg 15420
ctccttcttt tttacaagct gttatgaatt agccttcaca gagaaagaaa aatttttata 15480
aataactgga aatgaaactt tgcaaaggac tgcagatgaa aaactttgtc aaatgactgt 15540
aaaaatatac tatataattt tcaaaagtta gaaagtacca aacacactca gtattcatgg 15600
ttatacaagt atgcatacac atgtattgct ccctgaaaag tggtgttgtt aagggagttt 15660
ttcttagtac gcggcttaac atattttttt ctgtaatttg ttgttagtta taatggggag 15720
agaaaacagg ttagagtctc ccctctcagt ttcaccttcc ataaaacagc taaactagac 15780
gatcgtcaga ctccttccag ctgaaaacat ctgtaaaatt aaaaacaaat ctaaatgtat 15840
gcaagatatg tatttaaaca tgctggtaat aagtgtgctg tccctataat ttagatgcta 15900
aaacattgat gtcataataa taacaacacc tcgcatttgt acagcacctc atagtttaca 15960
caatgcctta acattcttct ctctcagcct cctacaaccc cacaggattg ggatagcttt 16020
ccagattggg aggtgaggga cccaggctca gagcgattct gctgttgtcc gtaatcacca 16080
ggctggtgat cagtgggcac tgggtgctct cctgctacac agcactgtct ctcaacatgc 16140
aggtcaaggt tacttattcc tccttcaaga cgtcattggg ttttttagct atggatgccc 16200
catcactttt agttctattt gtgaatcaaa ggctaaataa agtattcctc aaaatttgtt 16260
atacttctgt tactaatgct taatgtccct cacaatttct gtatatttct gtgtatttct 16320
gctctgtttt ggttcctttc ccaggtttct tttttgttat gaagtagttt ttagactcaa 16380
gtctcttctg tatgtgttat aactgcccat tccataagat acagggcagt gaatttgtga 16440
gccttgaaaa tatttacttt agaaatgaga agtatgactt ttcaacgttg tgtcatcaac 16500
ttctgtaaat tttccagacc tataaatact tgcagaaaaa aaatgaaagg agaaggcaac 16560
ttgatttagc agttgggtca gttagcaatg cctatggcaa gctgtagtaa ttcccttaca 16620
tagatttgta agactcattt ctatgattta aatgaaggca tacacttaac ctctttaggg 16680
tgtgaaacag cttttacaaa aagagacaaa cttaagaaac agtgtggccc tccaagagtg 16740
ttcattttcc atatcatacc atttgtaata agctattctg gctgggattt acttgcaagc 16800
attggctttt aagaagagat ggtttcacac atcaaattat tcacttggag gcactttctg 16860
ggttgaagga atggaatgga gagtgcggca gtgagtagat ctctcagtga cggtgatgtg 16920
cctctcccag aagaaatttc aaaatgcagt gttcattttc ctccacaaga aaggaagaaa 16980
ctgttttgtt attgtttatt cctaacatag tggaaacttt tcagtactct ggcagaaatt 17040
tcccaaaagc aattttctat ttcatgatta taaagtagca aaggaaaaag tcctgcactc 17100
cagctgagca atggatctcc agttgttatc taggtgctgc aggtttagag aggattgcca 17160
ggagaacaca tcgatttttc aggcctgtga tgacgtatct cttgttgaat aagtaaaccc 17220
ttccagtaaa cagacagtta gtatattgat ttcagggtgg ctttagccac tgaacctgta 17280
agtcttgcaa aggttacttg ggcaaaagca tcattatttt accttcagtc aacaaaaatc 17340
tacctggcca aggcagaaca gaaagttcag caatttgatg aagtgggaca acatgaagaa 17400
tcaggtgagt tgcctacttt ttcacttcac tttccacctt tagagattct tgtttagatg 17460
cagagtagtg acgtgcctgg tgtcagggag agagttgaat gagaaaagtc ccagaagggc 17520
agaagacttg ggtgattatc tgagtccatc tttccttatc acatgacaga gttcttgaag 17580
tcttggctag gaattctagg cttttagatt ctttgggcaa tggctactaa atgttcataa 17640
tgttgctcag ttgcaaaaac aagacattca aactatagcc agggagataa gtagtcacga 17700
actcaaggcc taaattctgc tgatggagcc gatgagaatt gggtgctaag gcaaagagag 17760
ttgccaatat tatattcttc ggggtttttt gtttttattc gcattttgga aaaggaaaat 17820
attagcattc ctctgactta atattgagaa gacattgggc actctttttc ctcccacact 17880
tgtcttcttt cactaggtga caagggaaga ggtagcatga ggtggtggtc acaggtgaga 17940
ggggctgttg tgagcacagg catgttgact gcacattggt cacctagtag aagttttgca 18000
ggcttggtga cttctgaaca ctgttttcaa ggttgatttt tagttgagag aacctctagg 18060
taccacgtaa tgttattaac agtagtactg atctcacaat cgccctatgt cccattcaca 18120
agatgttctg ccaagccata aaaggcccag ttaagtttaa gagaagtctc aaaagtaaca 18180
gatgataact aattaatacc cagtgatttt gaaatgtaga catcaaacat accaattcag 18240
tggtatcatc cttagaggca gacagaggat gattaaatca ttcagcccat ctctgtctga 18300
ggacgcagct tagcacagca tggtggaggc taaatgggcc ttaagggaaa aaatgatatc 18360
tgaagatgca atttatttca aaaagagttt gctcccgtga attttcactc tctatgtaga 18420
acggcaccag cacacacttt tcctgagcct ttgcatgtgt ggcaggcagc ggcctggcat 18480
cctggggaac tgaatgagga cgcagatgac ccggacgtgt tcacagtttg acacatctga 18540
ctcccagatc agggacagct agctttgctg gctggttaag ttgatgattc catctttgcc 18600
tggttctctg actgtctcat gctttctgtt attactattt tgcagcagat atttctgctc 18660
atttttcaat catatatgca tcctggatgg catagagttg attctcctaa caaatcagtg 18720
tccctttgta tttttttctg gccataagat agaatatata tgtcatttat taaaaatgga 18780
gaaaatgttc aggagtttct tgactcagag agggaaaagg gatactcagg gcactttttc 18840
agccaggaat ttactacctt tgcagggtaa aggggactca ccacgctgga agtcaaaata 18900
agccaccagt gccaagtgtt caaagccctt agaatcacaa tgctcttaaa gcaaagtctt 18960
caacaatgct tgaaaacttc cactggttct cagtatgtcc aaaattgtca tgtctatgaa 19020
tgattttctc aatctgaaaa tttttatagc aggctaaaga atgagatagg tcagtgtgat 19080
tctagaacta atcattaaca ttcaatagat gactatttta ttctagaaaa agcagcaact 19140
ttctatttac tctctatttt gagggtaaat tctctgtaag tagaaaaagc aaaatgtgga 19200
catgggacta acatatgaat atacaaagca aatgtaccga aaaaatctta agacctgcct 19260
tgtggtgttt tttgttttgt tttgttttca ttaaagtgac ttgttagcct cttgctccct 19320
gtgaagcaca gggaggtgac gtgatgtgca cagggcagac tctgccatat gccctggcct 19380
tgaactcagg gccccctggg gactgcaggg gatgctggcc atgctgagca atgcctgtgg 19440
gtgtcagttt cctcatctgc agaatgaggg taggcctggt gcttatttca tagggtcgca 19500
gaggggattc agtgacaggg tggtgtagag gctggagcgt gccccatgtg tgcacgacag 19560
ccttccaact aggggaggcg ggcctgggct ctcaccagag agcctgtgtt ctccatggct 19620
acatgacttt gccccagacg tccttcccgt ggtctggacc ctgggaagtc gccaagagcc 19680
agacaggaga aaggctccac ttggctctcc tctttggtga ccatcccttg cctccatggc 19740
gggactctca ggtgacatcc caccaaccct cactttgctt ccctggtggg tctcactttc 19800
cctcaagagt gttgcttttt tgtttcctgc atagtcctgg gccagttttg ataaccctct 19860
tcatttcact tcagaaaccc tgatgatttc ttcctgtgct ctttttacct taggactttt 19920
actatgacga ctgtgactgg cccatttctt gttttttttc tcttgctctg ctttctcccc 19980
catcatcact aaagcagaca tggcaatgat ggccatgcac actttccaag ggtccagctg 20040
tagatcttca tggttcccca ggtgcctgga ccatcttgtg aggagggagg caaacacacc 20100
ctgcctggag cacttggccc tttcggcaat gttttggctt cctcaagtga gaaaagaatg 20160
gatttgtatt ccccctctgc attattgttt ttgttttgtt tgtttgtttt gttttgtatt 20220
gagacagagt ctcacttttt tccccaggct ggagtgcagt ggcccgacct cggctcactg 20280
caacctccac cttccgggtt caagtgattc tcctgtctca gccccctgag tagctgggac 20340
tacaggtgcc cgccaccaca cctgactaat ttttgtatgt tttgtagaga cagggtttca 20400
ccatgttggc caggtgccca ttattatttg atctggaatt aactgagcta ctgcaggaat 20460
tgcttgattc actgatgact ggtgttgagc cagtacacac ccacacccaa ggactgtgac 20520
tgtcttctga ggtccatcct cagaaattcc tgtctcttca cctagtgtgt aataaggcct 20580
gcgcgtgtta tatggaactg taaaaaatgc gccaaccatc tgtccttcct ctttatctga 20640
ttacttatca ttgttctcta agttgcaagt taatagactg atcataaatt aatgcatgct 20700
ggagacttgc tgtttcctac tagcagcata taaaagttat ttttaaagtt gttttaaatc 20760
tgtgagtaaa aataaattgc tttgctgcaa gaaacaccaa acatggaaaa gctaacggtt 20820
caaagttaat aatttatctt atggacatca ctagtggcat agttgcttta aacagtgaga 20880
ggatttaata gatatttgat ttgcaagtgg gatgaagggt ggtctaacct ttgtcctgtg 20940
tttaccttcc atgagatcct agaggttgta cagcacagta gtggcatgtg acacacttga 21000
gagtgcctgt tctgtttgga aacctggaaa ctatgaaggg aagtggcctt cgagcttaac 21060
acataagact tgggaggcaa aaccttttat tctctttaaa tattcacttt aggataagca 21120
tttttttagg tgttaggaac agggaaaact gtgtggttag gaaggaagaa agaagaaagt 21180
taactgttgt acattcccta ggtaatgttt ttaagcattg ttattcactt tcaaaacaca 21240
ttttatttat ttggacttaa tattttgatc ttattttttc aatttctttt aatttaacag 21300
acaggatgag tttttttata gttgtattac ttagaaatta tactaaaaat ggccgagtgt 21360
ggtggctcac acctgtaatc ccagcacttt gggaggccaa ggcaggtgga tcacttggat 21420
cacttgaggt tgggagttca agaccagcct ggccaacata gcaaaacccc gtcttcacta 21480
aaaaaaaaaa acaaaaaaaa aactagccac gcatggtggc aggtgtgcct gtaaccctat 21540
ctactaggga gactgagaca taagaatcac ttgaatccag gaagcagagg ttgcagtgag 21600
cagagattgc accactgcac ttcagcctgg gtgacagagc aagactctgt ctcggaaaaa 21660
aaaaaaaaaa aggataaaga aatcatacta aaaacaaaac agaatgctga ccaccttata 21720
gaaatagaaa tagtggtttg ctgtgatagc aaattttctt gttaactttt tatttttaaa 21780
gaattgcaca ttcacaggaa gttgcaaaaa atctactggg aggtcctatc ccccttcccc 21840
caacctcctc cagtagtaac atcttagtag caaagttttg tatatttatt ttgatatcat 21900
tatctaagtt tgacatcatt atctaatatt aacctaagcc aaaagcccac tattttaatt 21960
atctagtgat gcagtgttat agaactcata gcctttcaca gcattatttg gaagttaatt 22020
ttcttaagtg aaatgttttt ggtctttaag gtttggaggc catggaggca tgaggagaaa 22080
tgggatgagg gagagagagc taagatagat aaagacagag atggggagat ccactgattc 22140
gttgaacaaa ccagatactt ccttatagtt tttggattaa cttacatgag ctaagtttat 22200
attctgttca gatcacaagt ggtcaagttt gtgtgtgtgt gggggggggg gggtgggtgt 22260
gtgtgtgtac cactctaccc atcctatatt tattgtcctg tatttggtct gttctgcctt 22320
ctttattttc aggataggtg tcctaaatga gggtctttgg aaagctggtg aggccatgtt 22380
gcccgtttca ggtgttccgt gctcaaatgt attcatttct tgaaaaattc agggagtgca 22440
cacttttgta cattttccta tgtgtatatg ataccattat ataaatctta aaaatatata 22500
tggttcacct gaatccccag ccatttggta gagaagatag aaaacctaca gaggaggcta 22560
agattttatt agaaaattca gcttctcgac ggaggtattg gctttaaagt caaggcaatg 22620
catctattct ttcttttgat ataactagct aaaagatctc ttaaattcaa agtggccctc 22680
atcttactgt tactgcaatt tactcttaat tacaaattat ataaaaatag gttttgaaat 22740
actgtagcga caaagtaaca tacctctgct ccattacaca gataaaacct ctaaggaaca 22800
cctcctctct taacaggcat taaccaactg cagaaactgc agaaggacag ggctatttgg 22860
gaataacaca gctcccttcc ttgtctgttc cctcccattg tcaggcttct gtggagccat 22920
attcagagca acatagggag ggggaagaga aaatcaaccc cttggtgaag gaaagctccc 22980
aattcacaga gcaaacatgg gtactcttgt ttgtgggagc tcccagggcc tcccagctca 23040
ccgagcattc tgagccctga tccttacact aattgtatta tgcaaccata aatgatgtct 23100
gctgtaccag cggggacagt ttattttaat agattggtat aacttggcag aatcttatct 23160
gcatgtttca tcttggattt ttagctcaat tcaactcaat aggcatgtgt caaatgtcta 23220
ctgcagactg agcactgaaa agctgctggg tacagggtta catggataga aaacgtagcc 23280
tctgacccct aaggagcctg taatccagat ccccattctt tccatcccat tctcccaagc 23340
aagaatttac ctaatgtggt ttgcgagaat ttaagagctg gaaaggtggt cacgagaagc 23400
cggaatgggt tcgctaaaat gtgtctatat gattaagcat aacgtagctt tgcagcactc 23460
ttcacagctt cctcagagcc ttccgcacgc ggtgtctcat ttgaatactt gtgtgaggat 23520
agcctcatac ccctcagtga gctcttcatg gagtgatgca gtagacagca agcctcacac 23580
ttctatgctc acggaagacc aaatttgcct tgaaaaatct ttatagtctc ttcacatttc 23640
taagttgaca tcaaaaatcg gttaccataa aatcctaata gttgaagaga tgtaatttca 23700
attatttggt aaacctgacc ttcattgtca aagcaattag tcaactcaga tttactttct 23760
cccagataat agattctgac ttcttttttt ctgattaaaa aacttaacac cttcctcagg 23820
agatctatct cagttctgaa tgctgattct aactaagaag gatatttggc tacatgctgg 23880
gaagaggggt actgaggcac gccgcgattc cactccagca tttccagtta gtcgggtgcc 23940
tctgcactcc cggtgttccg gcgcccagtt agttgtgtac tctgggctgt ccctatactg 24000
gagtcctaaa acacttacga ctgcagatag ggggaggttt ttcaaaacct tggtctgaaa 24060
agccatagaa gggagatagg aaagcggggg ggtggagcca cagtacattc aggtggatcc 24120
gtttttggaa atagtacaaa ctggaggtga aaccctggaa attgatctgt cgttcacatg 24180
cttcatgccg agtccttgtg gacccacaga gacacactcg ccccagtttg aaggctgcta 24240
acttgattct gaggacacca gtgaggtggt agtgtgcaaa tgatgtgtga ggaaactttg 24300
gaggagtctc accctgcctg gagcacgtgg cccctaaaac agcgcagcct cccaaagaca 24360
gaagatgtgg actagtgaga agccaggtat ggtgactgct gctggatgaa gcttgtccca 24420
ccagaggctc gcttgtttca ttgagcacct actgtgtgct tgtgggatgc aaacacacgt 24480
gtggtccctg ccctcaggtt aataggcagg ggtggaacag ttatgaaact gctctaaagt 24540
cattttctca aactgggagt gacaaatgta tccacttgga aaagattgag aattttataa 24600
gatttttaaa tttttgttta ttcacattga ggagaatcta aattcttttg aacttatgta 24660
tagatttcac cattttatag taataaatca gtcctcctgt gtgtgtgtgt gtatgtgtgt 24720
gtgtgtgtat gtaaacctca ccttgcaata ttattatttt aaatagccac ttgcatctta 24780
aggaaattaa gaggacaaaa gaaaagctgc tgttttgtat gtatccacat atttaccagc 24840
tgcttccctg ccggcaggtg ctctggttct gcactgcctg ttgtcccttg cctgaaaatg 24900
gttgcctcca atattttgct cagttttctg attgtttaca gtggcagagg agggtagatc 24960
tggtaccagt tagtaattgc cagaggtgga agtctgtgga tgaaatttgt ataacatgga 25020
acgttagttc cacagttaat gctactcaat tggaacccat ggaaattatt ttttggtgaa 25080
aagggcccat gcgttatgaa atttgagatc catcacttta agtgaatgta ggccctggat 25140
acagtgggag ctcagaagag caaatcagtt ggtcaccttg ctcaacgtat tttactaagg 25200
gcatcagtaa ggctttctat gacctgctcc ttcaatgctt ggttgacatt tggggagcaa 25260
agataaacta aggattctaa gttctgtcct gtgatgctgt aaggggaatc tcaaacctct 25320
aggtggagga gtgcagagat gaccaggatg gtggaagcct gcaggagagc tgaacacctg 25380
aagacaccca gtgggaagac caggaccttt aacgcccata tctgctgctc aagactggca 25440
gagagaagag ggtttgtgat gagaaaaggt ggtgaaaggc acaaggaggc acagagcatg 25500
tcaggtccca tatcccaaaa ggaatgtgct tgggtgaggg agagctcctc catggctgga 25560
ggcattcaga gaccaggcag tcgcttgtgg gtttgtgatt agagtgaggt tcttttataa 25620
agggagtgag aagagaaggt ctgtggatac ttgagtgtat cggtaattaa gaaataaatt 25680
gtgtacatcc catttctttc cacattttcc tgggctgtca cagtggctgc aaagaaagca 25740
gtccgtgaac tgaactgtga tcccagacag gcaagcacac caggaatctc ttctcagctg 25800
ttgataatga gggagcgctg gggagagaaa tggggtcctc tttgagtttc ctctgtgccg 25860
atacctttct ctttgttaaa acagctaatt aaacactgaa gcagtatagc tctcttacta 25920
tacactggta gtcatagttc tcttactgtt ctcttcactg acagttctct tactatacac 25980
tgatggtgac gcagaaattc agaattcccc gcatgtgtcc cggtttgaaa gccactgtgc 26040
tttgctgtgg attaggatca gacagttgag tcttgttcca acaaggaaag ttgcttattg 26100
gaaagttttg ctgcagggag ccttgagttc tgcatcaggc ttggaagtgg gctctgtgga 26160
ggtcagaagg aggatccccc acccgcagcc tcaagaaaaa tatgaaaagt ggattatgcc 26220
tctgtagcta tattgcctat aaactttctg cagaatgaca gtattcatat cctacatttt 26280
ttcaaagcga tattaatcct gagacctgca gctaaagtca agtagaattt agggataatt 26340
aataggagga aggtggggtt ggaagatctg catgattata gtcctctgat ataactggaa 26400
aattctttcc attagcaagg agctttggtt aatataaaat ggacagatta aacctaggca 26460
atttatttta ctcattgctg tatttttatt tcagagctgg ttgaaaatat tacaaagtaa 26520
tattttaaag tgcttatcta aactcttact ctgcatttta tcattgggtt atgaaatgac 26580
tggggaaaga cttttcttgc ttttatttct cagtgtctac ttataaacat gttttttgaa 26640
ctactgtttt tgtgacaaca tgcctttttc ccagaaaatc tcaggttaac attaaatagg 26700
cactggatgt ttatctgatc ttgtttatag aaacacaaga aaattttaac cttgtatata 26760
ctttactcaa ttaactaggt aagaggtcat tgaaacattt agaattccac tctacatttc 26820
aataattatc aggtgaaagc tactgcatct acatcagaag atgtttgtaa tttatttaag 26880
aataaaatta gctatgcaag aaatagtatg tggagtccta tgtggaaatc acagaaaccc 26940
tgacaacttg atgatctttc cgcaagctaa aaatatcact ctggatcaca gcagtagagg 27000
actctgtaaa tttaatctgt gtgtctcctg taaataagtg cattagcagt acacaggtgg 27060
tgtcagagtc agtgatgatg gatagaaatt ctacataaaa tccaggctca gtggctcatg 27120
cctttaatcc cagcactttg ggagtctgag gcgggtggat cacctgaggt caggagttcg 27180
agaccagcct ggccaacatg gcaaaacctc gtctctacta aaaatacaaa aattagctgg 27240
atgatggcac atgcctgtaa tcccagctat tcgggaggcg gaggcaggag aatctcttga 27300
acctgggagg tagaggttgc agtgagccga gatcacgcca ttgcactcca gcctgggcaa 27360
aagagcgaca ctccatcgca aaaaaaaaag aagtaagaag ttttacataa aaacgtggag 27420
tgagcccaag gtgccattta tccagcccat acacatcgta ccatgtacag agtggacacc 27480
agataaatac attgactgca tgccacaaac atatatatgt aggcaccgtt gcattcaaat 27540
acacatctgc agccctaaca catctttatt tgctaacgag catcaatgta tttaaaaaca 27600
aacatgttta aactagtgaa tgattagatt ataatgatct taattcataa gttttctcat 27660
tggccttttg tatacttcaa ttgtaatacc tagaaaaaca gttatgtcca aaggagtgaa 27720
taggccttat ctgaaacagg tgagcgtgac aagtgttttc ttacttattt tacttttcag 27780
ataattcatc cttaaagtac attagtttaa aagtactgtt taaggaaaca gtacttggat 27840
taaaacttga atcattgtta aggaaaacta taccttaact tcatgtaatc acaattaaac 27900
ctcttcatat agaaggatct aagaattttc tgcagcattc accagcacca aaaagctcag 27960
agacatatat ttctttctct gtatatgtat tttaaattca agttagtata aattgacagg 28020
caggtcagag taatatatga tcttctgagt ccccttagta attaaaagaa atgattattt 28080
ttgcatgaaa tatgataaag tgattttaag tgcctgataa aaagtcttaa ccatgacaac 28140
cattaaagat tacatcaaag aaaaataagt ttgactttca tttaccttgg aaacagctat 28200
taactggtaa cctcaagaaa caccatgaag agtcagtttg ctccacacat gtcttgtaaa 28260
agtcaaataa ctggtggtta tccagtaatg acaagaggta gaagttacat ccttgctgtc 28320
tgattgaacc ttcccagagc tggcacaagg ctgggaagac cataggtgct aaatgaggaa 28380
ctacttaaag aaagaaaatg gaatttcacg gacaagaaaa tccatgtcca tttggttctg 28440
tgacccacat cctttgtatc ctatgctttt ttacacttgg tacatggttg caagattgcc 28500
cctgttttct acttatagtt ccatgcagca tggatgtggg aaaaagtctc ctctgcaaag 28560
ggggttaatg caggtcactc tacgtatgtg cacgaggtcg ttataaagct cgaaaatatg 28620
ggctcaccaa ccaggtgatt tttttaatta tccaaccaga agacataaca tataggggaa 28680
tcaaaagaaa tctctgagta aaataatgat aacaggtcaa actttgcggt cccacgtgag 28740
gctggagatg cgtattgtct tgactttgca tctacaagtt taacaaatga tgctttctca 28800
gtttacctct ggaaatggaa attagcattg caaatgactt catgaggagg tagaagctat 28860
ctgtgaattt cctttcgctg tgtttacgat agactctcac gtctagatgt gtcatgtatt 28920
atgttaaatt ggtatgtctt gaagttataa agcacagccc tctataagta tatatattcc 28980
acctctttca aatcggatgg tacctatcct tcaaactgct atttaatgac tgtctgctat 29040
gttcaaggca ctgctctcaa tgttaatact tgatgagatc gggcgcgttc aaggtggcat 29100
ggccgtagac tcaatgttag tatctgaaat atggcctacg agctgagttg tgaatcaagt 29160
taatagattt tcggaatgtt aaggtctaaa ccagtagctc ttaactgaga caatcctgtc 29220
ctcatctcac ctgggagaca tctggcaatg tttggagaac cttttggttg tcacactggg 29280
gcatctagtg agtagaggtc agggatggtg gtaaacaagt ttttttgttt gtttgttttg 29340
tttttgagac agagtctcac tttgtcaccc aggctggagt gcagtggtgt gatctcagct 29400
cactgcaacc tctgcctcct aggttcaagc aattcttatg cctcagcctc ccaagtagta 29460
gctgggatta caggtgtgca ccactacact cagctaattt ttgcattttt agtagagacg 29520
gggttttgcc atgttggcta ggttggtctc gaactcctgg cctcaagaga accgccccct 29580
tcttggcctc ccaatatgcc gggattacag gtgtgagcca ccgtgcccag gctaacattc 29640
tttaatgcat aggacagccc ccaccataca gaggaatccc cagcccagaa tgttaatagt 29700
tctaaggttg agaaacccaa ggttaagcca agtcaactta tctatcttct ttaaaattgc 29760
ataagaatgc agtcctgttc ttcattcctc ttgctttgca gttaatgatc ctttgcctgg 29820
actttctaag tgcccagaag agcaacagcc agcatgcagg atggcattcc tgaccagttg 29880
cacttggcct agcattccaa cctcacctgc ctcagcttgt tcaacctgaa aacctaccaa 29940
gtgaaagcaa gagccacgtg aagacgcctt agttatatgc acccacccag acacttgctc 30000
agaaaggaat cagtggggcc ctggccttag aaactggctc cttcactgct gtagaaacaa 30060
cataaattta acataaaaca cgtgcttttc ttttttcttc ttactttttc ctgtcttggc 30120
aatgcaagga tgccattagg taaagaaatc cttcaccaca ctaatcctgc agagccagaa 30180
gagaaaccag cttgttctaa cccagctttg tcatggagag aaggcagctg ctccagtctg 30240
aactattctt tcttttggta gcagcctgcc caagggtgaa agtgtgttta atagtttgaa 30300
ttacacaagt gaacagtaaa tgtatgcctg tttctgcttt atgggacttt gaaataatgt 30360
tgtttgtgcc aaggttttag attactatac ctaacaacct agaaaaagaa atgaaaagga 30420
agccttctgc caggcagagg tcactacggg cctggagctg ggcacctgac tcagcagctg 30480
cccagatccc cagagctgag aagtcaccat gcatttgtgg tgcttcgagc gagttaccag 30540
agtcctggaa cagagcagca cacctgcggg gtgtcccctt ggcatttggg cagggcaggt 30600
gaccaagggt cttgttggaa ctgaagtcca gcttgaaaag caaatctggt tgtgagctag 30660
agtccagtaa cacttgtttc ccgccgcccc ccgcataact cgtgtgtcct aaaatacaat 30720
aatttcttga acttcagtca cttatgccta taagcgggca tacaacaggg gcacaataaa 30780
tgtttgttaa gtgaatgaat tctttcagaa ctagatggga tcttagtcca actctcttat 30840
ttaacgaggt ccacagaggt tctgcgattg tctaagaaag aaggctgtgt tcatggcctt 30900
tgttgtttac gtggccctgt gattctcttg gctccgtgaa agtcctgatg cagacattcc 30960
ggccatctag aaaggcatgc agacaagcca tccagctggc atgatcctga gtccagcttt 31020
ctttaaaaga gcttccaaaa ctgcttaagc tttgactgca caaaacctgc atcacctcca 31080
gttgagaaac tcaagagaat aagtaagtta tggagttgga gaccccagct taactactag 31140
ttttaaaata gtgaaatcaa cattttcaaa tctttgactt cactaagatt taataaagtt 31200
tattaatcat atattatgag ttattgctct ctctttatgt ctgtaatgca gttgctcctc 31260
tctgtataaa ttaataagtt ttagagatcc aaaatgagaa ttttaaaata aattacgtat 31320
attttaatca agtttaattt gactatatcc agctaaacaa ttgattgaac ttcacttgct 31380
tttctatgac aggttttttg ttcttagtaa aagaccccag ttttctcact tgtgaacaga 31440
aggggttaga cttcatgaca gctaaggttc cttccgtctc taacaaaagt ggcctgaaga 31500
gaggcttcta gactatactc acggtgggtt cttgggacct cagagtcagc tccatcactt 31560
aagtggctgt gtgattgagt ggagacacct caatctcttt gtgcctcagt ttcctcacct 31620
gtcgagtgtc aacatgatgg cacctaaagc tgttgagact tcagaaaggt aatgtgtgaa 31680
aagtgaaaag tgcctggcat ccaggaagta ctcaataaat accaactatt ttattgctgc 31740
agctgttctt atagatgtga tttctagaac attgccttct aatagggtag ccatgggcca 31800
caattgttgg ctgttcggtg tttcacatat ggttagtcca aactaagatg tgttgtgagt 31860
ctcaaataca cactggattg tgaagactta ggacaaggaa aacaatgtta ataaaatctc 31920
attgataact tttaaattaa ttacatgttg aaatgaaaat atttgggaca tattgagtta 31980
aataaaacag gagattaatt tcttctgttt ctttctactt tttttattag tgtggctact 32040
caaaaatgtg acattatgta tgcatctcgt attacatttc tattggacag cagcgctcta 32100
gacagtacta tgggtagtat ctgtggggag gttctcagaa acatgtcgca tgctctttta 32160
gaaccttaaa gtattcctag tctcctctac ttccagccct tggctcttgg gcctcagtct 32220
ttttactttt gcggctgtgt ttctctgaag gcttggcatt agtagattga aaagaataac 32280
catctaggga aatgtgaatt cagtttcttt ctgacattct gctctctaca aggggatatt 32340
atgtacacat aaacctactt ccaaaataat gaagtgaggc ctaattcctt actcttcaga 32400
gagcccactg tggaagtgtc actgaccttg tgtatgggct gcccttcatg gctctgggag 32460
tcattataaa gggcagcatt tggcgtggtg cgtcctaagc cagtgtttct cggctctgtt 32520
ccttagacat gtgttagtgt taatagatgt tcttggaaaa aaaaaaaaaa aacagcattc 32580
tgaggtcaaa catgctcaga aagcttggaa tctgcactac gcttctcgta cacatttcat 32640
attaaagatt ttggaaagtc ctgcaataca gagccctgtc taatattgcc acaacccaca 32700
attgctcaaa tgtaaataga tttgagttta ttcacattca gatcacctct taaggcccca 32760
cctcccaatg ctgtcacaat ggcaattaga tttccacatg agttttggaa gggacattca 32820
gaccacagca ggggaaagca gggtacttgc tgctttgcaa gtgtgtccac atctaattaa 32880
tagtacagtt cttactcttg gtgtgtccgg tgatattaaa aattaatgtg ccttatttag 32940
ataagtaaca taaaaatcac aaaatgtatg ccttagattt atatgtattt ataactagtc 33000
tatttcctga aaacagttga gacaccttgt aaaagttacc ggtacgatag ggccattcca 33060
acaaagctgt aaagtggtga taacacagtc ataaagaaga ggagatagct ctgggagaaa 33120
aggtggccca gaaaccagct ctgagcctca tggctgcagg caaggtctgc aggttcctgg 33180
tcctgattgc aggccatttg ctgccttgag tggtggttac acaaggccag ccctgggggt 33240
atcacccaga acacctagta cacgaatttc agtttagagg acgaagcatt actggagtat 33300
tgttatgcag gaaaactttt tcctaaaaat gccctgaaaa gagagtagcc taatgcattc 33360
aatcaaaatg tttttaagtg gaaaacatat tgtgtgtact tgatctggcc tgctgctttt 33420
aaaagattaa aactgggact gggcatggtg gctcacacct gtaatcccag cactttggga 33480
ggcagaggca ggtggatcac ctgaggtcaa gagttggaga ccagcctgac caagatggtg 33540
aaaccccatg cctactaaaa atgcaaaaag ttagccaggc ttggtggcgc atgccggtaa 33600
tcccagctag ttgaggggct gaggcagggg aatcacttga acctgggagc cggaggttgc 33660
agtgagctga gatcgcatca ttgtactcca gcctgggcaa caagagtgaa actccatctc 33720
gaaaacaaac aaacaaacaa aaaaacactg gggccaaaga actctgtgtg ctgtatcacc 33780
taaccacatt tcatgacacg gctagagaag aatcatgcaa ataaaaattt ccaacatgtt 33840
cgtaaactgg gaaagtattt cactggggag tgagcagaaa agtaatacta taacctctat 33900
atctagacaa atgtgaattc agtttcacat ataaatatat aagtgaaaaa atatataaat 33960
ataaataata tgaaataatg gttatctcac cactttctac atcttttgtg aatattttat 34020
agtgctcaaa tatattagtg cactagtata tgtacattac attaaataac taatcattta 34080
ttaggaggat gtgcttgttt tttgctaata aagatgataa taaaaaaatc cttagacccc 34140
ccctcggttt gttttcagtt aggaattagg gatatttata agaatatctt taaatgacac 34200
atgccttgct ctgggacgag gcatctgcat gggtgacaca tatgtgttgt gtgtacaggc 34260
tcccagcatt tccagggccc tgctcagaat gtaggcctta ctgattctta cagagttaca 34320
agcgctggtg aggttggcga agtttaggta aacacagctg ggaatgcccc atggcctctg 34380
ggtgactttg gacatcactg aactttaccc ttagagatgc atacctgcat cttttttacc 34440
ctgatagggc cttccatgat gctttcaaag tgtttttgtc tgcttttcgg ttaatagact 34500
ttcacagtag ccaattgaat atattggtta aatgcatctc tttatacaca gactggattc 34560
aaactgaggt tgtgtctctc cctggctgtg tgacgttggg tatgatccaa gtgtcagatt 34620
actcaacttc aaaatgagga cagagccttt cccttctagg gctgccagga acattgaatg 34680
agagagtgct ggcagcttag tacaggtgtt cattgctctt gtatggtact gtctgtggca 34740
cggctagata aaatacagta gccactgatt caaatttcaa ctgaggagta aaataaactg 34800
aataacttag aaaagttttc ttcttttgaa tgactctaag aatttaagga gcatgtgagt 34860
gttgatggct ctaaaagggt aacagagccc aactagctca gttctcagca tgaaaatagt 34920
catatggcac agactcagtg gagtgggtgc acttcaataa ctggaagcac agatgcccta 34980
cagcagcatc aaagatggca ctctaaacta ctttcaatcc tttaaaataa atggaaacgc 35040
acatttagta tgcatatgac aacacgaagg acttcgattt tgctgatgca atacagtttt 35100
acaggatttt ttatactcaa attagtaaaa ttctgtattg catccaaatt ataaattata 35160
atatcatcta gattggacat aggaataacg accactggta tctgcccaga aagctctacc 35220
gcctgtttat aagctcctgc aggagacaca aaaagaagag aatttgaata taacttgaaa 35280
tgaccgtaat ctcctgcccc aactcatttc attaccaaac cgcctctttc ttcattattt 35340
ctcctgaagc acaaatctat agagaactca gctgccagtc tctcccactg cactcagcag 35400
tgaaagggtt aggcctaggc ttttcaaaca gaccagtgct tgtatcagcc cttaaacatc 35460
tctggagaag gaaatgggat ccttctttgg taattcattt ttgacagttg gggattaggt 35520
gttctgtatc tggggggcct tgctgtcttc tctcctcctc ctcccactgc agaccctctc 35580
ctcccctccc ctctccagct ctctgatgac tgcttcatgc tccttccacc tgaggactgc 35640
cagcacagcc tattgcagga acagccaatg aggggctggc tgtgctcttt tatttataaa 35700
attataaact caagcaaaat ctagactatg tgtccccaag atcagaggag cacaaatccc 35760
ttgcttacag attgcatggg gggcacattc tttaaaattg gtccctgatc tagactctag 35820
cctgagaatc atctttaagt tcagaatttc cactcatgac ctcacatctg tgggctccca 35880
cattgtcttc caaaacacac atggcatctg gcatcacctt cacccccacc ctcagagcct 35940
catctccctg caggtagata gtcaaggcaa cctcttcact cttctgccaa gcctcctctc 36000
ctcagctctt cccttcctct ctctttttga aaatattttt aattgtggca aaatatacac 36060
aacataaaat ttaccatctt aatcatgtat aaaagtggag ttcagtggca ttaaatacat 36120
tcacgttgtt ctatagccat aaacaccatt catctccaga gctcctttca tcttgcaaag 36180
ctgaaactct gtccccatta agcaatggct ctgttttcct ccgttccccc agcccctggc 36240
caccatcctc agttttctgt ctctgtgagt ttgattactc taagcacctc ttataagtgg 36300
atcatacaat gtatctgtct ttttgtgact ggcttgtttc actttccata atgtcttcaa 36360
ggttcatcca cgttgcagca tatggcagaa catctgtcca tttccaggct gaatggtact 36420
cttttgtacg tgtggaccac atttcattta tccattcatc cacgggaggg cacttgggtt 36480
gcttctgctt tttagctatt gtgaataacg ctgctatgaa catagctgta tgcctttgtc 36540
ttttaaagcc caaatctgat caagtcactc cccagcttaa aaccttccac tgctccccag 36600
cagtgggata aaggccagtc tcccctgtag gtctctcccg ccagccctgc tcagtcttct 36660
tgcttgtcat ccttggctag gccttgcatt gccatagccc tctgcctctg ttcacgctct 36720
ctcatcttgg agcatgagcc ttccatcatc tctaccagat gaactctcat ttcttctttc 36780
aaaaaataaa aaacccaaaa aacccagaga tcccaactgt cctggtgtct gcatagtctg 36840
cagcacacgc cccctccatg gcccttcctc cataagcaga atcactcctc actgttcctg 36900
cagcacctcc tgtgtgccca cacagctgtc ctgcggtggg ctgtgtgtgt gagtgtgccc 36960
cctctaggac ctgagctcct tctggagggt gggcacagca tccattcatt ctgggaatcc 37020
tggtcggcac catgctagaa cttctgcaag tgagtgcctt tggtgctggc ccatgggaga 37080
gctgttggta aggcatactt ttgcagattc cagttgctgc tgaggttgtt gctctttgca 37140
caagtttctt ctagtcacca gtgaagtgac atgtgtggca ggcatggccc agggaggctt 37200
tttcataaag aagaggttga atctttgggg ctgtggtttg aatatgtccc tcaagcttat 37260
gtgttggaaa cttaatccca aatgcaatag tgttaggagg tggggcctaa tcacaggtga 37320
ttaggtcata aggctctgcc ctcatggatg gcttaacatg tttagtgagg cagtgggtta 37380
gctattgtga gagtgggctt gttagaaaat tgagtgcagc cccctcttgc ttgctggcta 37440
ccatgctctc ttgcttttct gccttctgcc gtggggtgac acagcaagaa gaccctcccc 37500
agatgctggc accatgccct gggactttcc agccttcaga accacgagcc agacaaattt 37560
cttttcttta taaattaccc agtctgtggt attctgttat agaaacacaa aatggactaa 37620
gacaatcttc tttcatcaag ttagggtacc aacctttaaa gactgccagt ccaaggttaa 37680
aggaaacttt tcaagagcag tccaaacatg atctggccct cagctactct ccagggtcat 37740
gccaccctat cacccactgg ctcacacaga cgctgaccac tgcttagttt ctcaaactga 37800
agttttcctc ctcagagctt ttgcaaaacc ttttctttgc ctggaaaact ccccccacaa 37860
atctttagtt gtaggttcct tctcatcttg cagaattatt agtttgctct tcaaatagtc 37920
tctccagcta gactatcaac tccaggaggg cagagttctt cttcgcttcc ttcacccatg 37980
tgcccactga gtccagaact gtatagcagt ttgattgaaa aaatccacag ggtggaggat 38040
gagaggaccc tggatcccag cctcacagcc tcttacttca cctgtgtgat tttggtcaag 38100
tcctttattc ttcctgggct ttagttttcc cttatctaaa atatgagaaa agttcccctc 38160
tcctgggtat tctgggagac tcatgtaaaa ggcactgagc cagtgcagca catctatgac 38220
caggaagggt cagcttcctg ccttgcatga gacacacatt cccttcttca tgcacagtta 38280
ttcatgagtt aaatatgtat tgagaagtgg gttctcagga gatgatgcat ccacagcatt 38340
gtttgtatgc ctctgtcttt gatgtccctg cctgagtcgc ccactttaga gcccttctgt 38400
tcttcagaaa ccagactttt ctttcaatag tttcagtaat caatcgatca atcaatcaac 38460
caatcaacag tgataataat catgagtgag cccctgcccg tgctggctgt gtcctgctga 38520
aggcacacta agtgctgccc ttcccagaag cctcaggaag cttgcgaagc tcaggtgcat 38580
ggatgcctgg tggaatgagg aagggatgca gccaggtaga gaaatgccct gccatcactt 38640
gcatcagcat ctgtgaagag ctggccaggc ttttgctcac agtggttgac acagtcaagg 38700
agcaagggcc ccgtaggaga ggggagtcaa gggctccggg tgggaatgga gctgggggct 38760
gatgctggct tctggagcac tgtaatgtga ctgagaaagg tgaaggagcc gttctgaaaa 38820
agaagaaggc aggagctcgc acagctcttg actcatcttg acttcttttt cctgcttcat 38880
ccaagcaggt cgactctctc gtgatctcag agacagagtg aagtcatgag tgggagggga 38940
gcacagaaaa taagaccttg attcccagca ttgggagact ccctgctccc ctgagtctcg 39000
gaaaatagca cccttcaaat gttttaggga tccagatttg atgaagagat gttattttgg 39060
cttttagatt cttaggagag atttgtcttt ctcaggtcag gaagaaaatg ctgcccgctg 39120
cacattcttc gggacagact cttttaatta ttactagttt aatgtatgtt ttgcttagtt 39180
aaggaaaacc cctgtggttt cttgacgtgc ttcagtattc taactcacag ctgattcagt 39240
tcagggggct ggggagatgt cctcgacctc tggaaaggag ggtgcatctc tagaaataag 39300
gctaagtatg ccactgacac tgtctgcata aacgtgtgtg atctcaggtc caaaggatgg 39360
ggcctggtct aagccaggga cgtgggaaat cattttcctg tggcaacttg tgaagaccat 39420
tctgtgacct tggtgtctct gggccttctc ttagattttc taagttggct agtcagtgga 39480
gctgccatcc ctcctttgcc catgttctac tcccagagtt cctccaagaa attgcggagc 39540
aatgcctgtt tcatgagagc tgagtttgct gtgtcttcca cttagaaaca acactgtgga 39600
ccaggaggac acacagctcc cagggccatc accacacaaa gtgaaggctg gtgaatccga 39660
ggcttctagc ccttgccggg ccaggcccgc agcactccgc tccccaaccc agccgctgct 39720
ttgtcgcagg aacctcagca gggcagggtg tttcctagga ggacatccga ttcccagcca 39780
ttcctttcag tgaatcacct gagctcacat tcttttttct tttatttttg aagctcttag 39840
ccaatctgct tcgcgatgaa ccagttttgc ttgaagcaga caaacccgat tgtcaggaga 39900
cagtgatgat ttcttcagtc tctgaggaag agttttcatt ttccccaatt cgcaaaaaaa 39960
gtcaggtccc tccctccctc cctctccgta gaatattttc catgtgtgtt aacaatggct 40020
gagcgtggta gatgccagga atttctgtca accctcaaag aggaaagccc tgcctaatgg 40080
tctgcccgtt cttgttcact ccctgcccca ggctccccac ccgccttctt tctggaaggt 40140
ataaaggctc ctgcttatac ctggcactgc acgcttcgct ccctctgatc tcctgactgt 40200
catgcccagt gtctcagcct atcattctac ctctaactcg accttgagtg accttgagca 40260
agtttctcag gattccacct ccaagtcact ctccctttgg gatatgcagc actaagttaa 40320
gcttgcctgg aaaacatcac ttgaagctgg aaaaccactt ttaacacagc gggaaaagct 40380
atttgttcag acaggagtgg ggtgggtctg ggcagagcac tgctctaact tggccatgcc 40440
gtggcagcag ctcctttaat gccacttttt cctggcgcgc ccgcggggcc tggagctcag 40500
aaagagggga acgctccctc gtctctcaac agttgctcca gacaggtcag caaacatgga 40560
attcagaatg ttcattaaac actggctgtg tcttttgtgt tcaaaagcaa gacactctct 40620
ctgaaccatg gccccacaga gagtgcagaa tgtgtgaaac ctgccgggaa ggtctggacc 40680
ccttgcgggg cagtgggcag caccgtgcct ccgttcacac cactcacatg gctgtgcctc 40740
tgcttccttc tggcatggct gcttcttcct caggtctcaa ccatctccct cagatgctct 40800
ttcccatgtt tgtggctaca ggtccccgtg acctgcagag gcagagcact caccagcagc 40860
ccagcctcgt tgcgcaccca tgtttgcatt tgcaggccct agaaccactc caagctccgt 40920
gtggcgagat gcaccctcct gcccttcact ggggagctgc cctcctgttc acagcggcac 40980
ctgagtcaca catctggagc catcctggac tgcctcattt ccccgatggg gggtttccct 41040
gacttcatcc atcctgtctt ttgggtcccc ataataactg acatgggtcg gcccgtacca 41100
gcccctgtga gaagggcttt aactgccttc ccaccccctg ctcatcttag agtctctcta 41160
tagtgctgct gaaagaatct ctaaatcagt ggttctcaac ctcagccgca cattgagaat 41220
cacctgggac ccttaaaaaa atcttaactc ttggtccaag aattctatta caatcggtct 41280
gggatggggc cctacaggta tttttttaaa gctctccagt tggtaatgca tagctagagt 41340
tgagtatcgc tgttctaacg tgcagatctg gtcatgttac cagcctttta ggtggtcttc 41400
tttggctttc tctatctaaa gttcaaaacc gaacatgtgc gcattcagtg cacccatttt 41460
caactgtgca ttaacacatt cagcccacca gcaagattta tgaaccattt tctgctgttg 41520
tatataacat atcatatgca taatggcata ggttattgtt ttcttcaaaa tatatgagat 41580
gtgagtcctt ctacgaactg actcacactg attgcccaac ttcctctctc gaggtctcat 41640
cctctttccc tgcagccgtc tccctcttgc acgcacacac acacacacac accacacaca 41700
cacacacacc acacacacca gggtcgatgc catctaccct ggacttcatc ttgaactcct 41760
tcgagtgtga gtcattactc ctttgtgcac ctctgctttc tcttctcaag atgttcacct 41820
gcttgaggtc agttccttga gcgtcttcca cttgccatgt tcaccacagt gctcaacatg 41880
cctgaatgca tggatggcga cttctcagat cctcagtctc ctcatctggg taataaggca 41940
ttgggttggc gggtccatct ggtttcttcc agctctgaga gtgcatttgc tctgtgattc 42000
attcgttcca caacacttca ccaattaaag agagggtaca aaaggtgaac atccttggct 42060
cccagcagat gctcctcaaa acctgaaaaa tcagataggt gagggaagat tgaatgaaag 42120
gcctcttatg attctgcagc aattttggtg gtttaagaac tctatggaaa aatcatcagt 42180
atttctggaa ttgaagtaaa atggatagtg agcctctgtg tatgtgaagg cccgcatctg 42240
gaacatgaaa gaacctgtct gatgtgttct agtcaggaaa gcaggtagcc aatactattt 42300
atagaattta cagaaactga agattttgtt tctactgatt ttcaaaatag tattatgtct 42360
gatttttttc ctcagaaata tacttcctgc tcttctcaac aaactcattt gaaaatatga 42420
ttagaacatg atagaatttt actcatttgc caactgcggt tcccatttca catattgtta 42480
gaattctgca tggtggcttt gccctttaac cactaactga taaatgatgt agttagcttt 42540
taaatgtgtg gaaaaatata atttcaggtt caaccatagg tcagaagtac acgtgttttg 42600
ttagtctatt tgtctctcag tcatctcatg gaaaattctc agcttttggt atggaaataa 42660
ttttcttgaa ggcaatattt gttgagtgac tgacggaatg aaaaacgcca gttgcgtaag 42720
tgtgaaaaag atctgggtgt tttcattgga tccaaattcc acatgagcca acaacagcgt 42780
ggtgtggagg ctggagcaca ttaataagaa cagtgtccta aattcaggag gtaatgctct 42840
gcccatgccc tgtgcagctc agacggtgtg tgcagtgcag tatgtaaccc agggcacatt 42900
tcaggggccc acagggagct gcagcttgta aggtggagtg cagccaacag agcagagagt 42960
cagaatcccc gcagagtggt tgaaggcaca aggatgcgca gcaaggaaga cagacttata 43020
ggtggtgcga ctgccatcct ctggtactga aggtgctatc atggagggag ggaagtagat 43080
tgaccctcct ggctccagag tacggaactc agacaaacgg tcagaagctt acagggaggc 43140
caattttgga tcaactttaa gaagaatttt ttaaaagcta gagcaatcct aaaatggaat 43200
ttgctcttta taaagttgcg aatgcctcac cctggaattg cttaagcaaa gttgggacgg 43260
gcagttgtga gtaatctcct ttccaatcca tacccgcaat caccagaaac gtggacttcc 43320
ctgacactga gcacctctta attaagcatc tcataagtga acaaaaccca gcccttcaaa 43380
gaagtcactt tatttatgtg tgggtctgca gcttggattt cttgataatg ttaaataaaa 43440
ctccatctac tcttccacaa acacttcaag aaacctaaga cttttggcca gagtaacacc 43500
gaggtttgag agaaaggata tgtgtgtgag aggtgtggtt tcattagaac atattatttg 43560
acttcatgtt gaatcaacac ttttgtgcaa aatgcagttt taccagcctc tttccttgtt 43620
ttggtcacat aatttaactt aacattctcg gtacttgatt ttctaacata aaatgggatt 43680
gagaggggaa ttttgaagtt cccatggtct gtcctctaca ttctgacagc tcattatctc 43740
tgcggtattg ttctcacatt taagtgaggt tagcggaggc agaggcctct caggcctgaa 43800
gatagcctct gttttcaggg aaatactaga ctgtgagatc tgtgacactg aagcactaag 43860
ttcatctcac aaaagcaacg tgctcttttt aaatggttga tcaaagttac tttcaaaagg 43920
aagtgttagt ttttgttatt agccgaaaca agagctgctt taatgtagta tatttaaaat 43980
catatctcaa ttaagatgtt attcaaatac tatttgaccc accaatctca ttactggata 44040
tatacccaaa ggaatagaaa tcattctatt ataaaaacac atggctgggc acagtggctc 44100
acgcctgtaa tcccagcatt ttgggaggcc gaggcgggtg gatcacgagg tcaggagttc 44160
aagaccagcc tggccaagat ggtgaaacct catctctact aaaaatacaa aaattagcca 44220
ggcgcggtgg caggcacctg taatcccagc tactcggaag gctgaggcag gaaaattgct 44280
tgaacgcggg aggcggagtt tgcagtgaac agagatgaag ccactgcact ttagcctagg 44340
tgacagagcg agactctgtc tcaaaaaaaa aaaaagaacc acttgcatat acactattca 44400
caatagcaaa gacgtggaat caacctaaat gcccatcggt gatagactgc ataaagaaaa 44460
tgtggtacat atataccacg aaatactatg cagccataaa aaagaacaag atcatgtcct 44520
ttgcggggac atggatggaa ctgcaggtca ttatccttag caaacgaata agaaaagaaa 44580
acaaaatacc gcatgttatc acttataagt gggaggtaaa tgatgagaac acaaggatac 44640
actggggcct acttgagggt agagggttga agggagagaa gcagaaaaaa taactattgg 44700
ggtactaggc ttagtaccag ggtgacaaaa taatctgtac aacaaactac tatgacacaa 44760
gtttacctgt ttaacatacc tgcacatgta cccctgaact taaaaaaatt tttaaaaaga 44820
tgctatgcaa taaaattctc aattaagaat ttaacttggt aaatgttcat ttaatgatct 44880
aaaaatatgt gtctggatgg ctctagcaaa aaaataaata ataagtttct cagagatggt 44940
aaggctgaaa taaatgggga aaaatctgaa ttgtaatcct ttttctgttg gacctggtgt 45000
tggggtttca cacttgtggg tgaatgtggg cctcctgtga gcaccagcac aaaagactaa 45060
actgaacaaa agattaaatg tcacctctaa aattctgtgc aacaagactt ccagccacag 45120
aatgtgcaac tcagatttcc aagtaaaaac acaccaggaa gcagatctta gatctctgtt 45180
atctccttgg caccagctgg tattcatcct caatgctagc tagagttgaa ataaagagtg 45240
aaagaacttt ctcttttatt acttaataaa cttccttttt tgagctgttt taggcttaca 45300
gaaaaattga gtggcagttt cagggagttc cagcacggcc cctgtttctt tctcatggtc 45360
cctgcaggtt tcccctatta ttaacgtctg tcattagcat ggcacatttg ttacaattaa 45420
tgagccaata ttgatacatt attcactaaa gcccacaggt tgcgttaggg gtcattcttg 45480
gtggtgtacg ttcttcaggt ctggacaaat ctataatgac atgcattcac cattactata 45540
tcacgcagag tcgtctcctg gccctacaag tcccctcctt ccccacctgc tcactcctcc 45600
ttcccaccct ccccaaactg tggcaaccat ttaacttttg actgaatgga tttattctta 45660
ttctgcctta ttgtatgtac accatatttt aataagataa aataatagtc tatagtagac 45720
ttctgtaaat actcaatgaa taaatacttg catgaatgca ggaaaaatca atcagtcttg 45780
caggatttct tatgcgttac atcgtcctta taagaaagca gtcattctca ccgagatgtg 45840
ctgagcagat actggacatg ttctgaccca gataagggct gggtggaagt agggctggag 45900
acacagagac ccagtgccaa cttccaggac ctcggaagaa ctgaaggcag agaggtcctc 45960
tcagtgtgga ctgggcctct gctggcagcc accagcgggc acagagctga tgtgtgttat 46020
gccacgtggg gaaaacctac agacgattct gagaaaggct cacagggaca ccctctgccc 46080
ctaaaagaac aatttaactc taatttattt ctgtcactct gcattttctg acctttccca 46140
agtgtacagt tttatatgca tttaactgcc aaattgtcat gtgagattat atggttatat 46200
ttcattaata tattctagtt tgttcagctg ttcttactgg gtgaatttgt gtggtttcct 46260
gacatttttg tttttagtag tgcctcagta gttttataca taattacgtt tcccttctgg 46320
attatttcct tagtatctag ttcaagaagt gaaatcgctg gattcttgtg gtaaattttt 46380
gaatttcaca gtataatgct gattttctca aagtctcaca ttctaagaaa gtataatgag 46440
gcaaaacaaa caacaaacat cttaagttga ttttttccta gcatcttttc cttccatctt 46500
tgcttgtaga atctagacta tttcatgaac ccaagatata atcagtatcc ttcttcagta 46560
tggccaaagt gagtttctca ttattttacc tccccttcag gaaatgactt ttcatcttgt 46620
gttttgggag ccatagatgg ttctgggcag gaaactggct ttggatagac ccagcatgta 46680
gatggctatt tggccttgct cccagtataa cgatgcagtt ccctgtgaaa gggtatgagt 46740
aggttttggg gctctggata ccgtgtggcc tgaagagaca agggctcaat gccaactctg 46800
cctgtttcca actgtgtaac catgtgagcg tcaaaaatca tggacgtgct ctggttaaca 46860
ctgagtggga gctcaacaaa ttattatttt taattgttac ttggacatgg ccaagttgac 46920
tacactttat gttctgctac ctgccagtct gaaagtgacg ccacagaagg tgaaccgcat 46980
gttgggagat gctcctcatc tgcttaaatg aggtgcaaac acagcccatg cgcctgctct 47040
tcatgactgt atctgtacca gcaatatttg tattggcaaa tcacatgccc cagtgggaac 47100
tacttaaggg gaattcaatg gatttcattc cttttatgta attggccact tagtaataga 47160
cgtgtaggtc tcttgtgtgg ataaggattc tgccttttat gtaagatatg tgttgcaatt 47220
cagctttcag gtcccagccc cgggaaggct ccaggccttc acaaactggc ccacccacga 47280
gaaggaaagc aattgtccaa atgtgggtag cttttcttcc cactgttgtc agctgcttcc 47340
aattagcccc catatacata atcccagttt gtgtctgtat cagtacaatt ctcccatgtc 47400
aatgtgaatt ttaagccaca gagggaaagg ggacagagaa tatgctttca ttcagctctc 47460
ctcgtctcac acctcttgcc ctgcatgcat ttctttgctc tgattaaacg agcattttat 47520
aagccacatt tgctgtgtga aaggcaaagt cttccctccc acggatgacg gtctccaggg 47580
atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtga gagagagaga gagagagaga 47640
gactgtaaac atatatctct gtgaaacttc attttccata tgtgaatttt tggaaccgag 47700
acaaatggaa cttagctaaa agatgggaaa ggtagactga ctctgactta atctacttaa 47760
cctaccaggc aatttataac ttgatggcct aatttttgca gcacccagaa gcaagcctgt 47820
ttcagcacgg caaaggctca gctgctaagt gggcagcatt gttggaggtg agcagcttag 47880
gctgactgtt catcaaagga ccaagcgctt gaggttcgct catcgctgga ggccagagtg 47940
gggagggcca tttaactgct caaggccatg gaactctact gtcagtttca gggaaatttg 48000
ggaccctgga gcacaaacca aaactccaat taaccaggag aggaactcga tccccaggag 48060
ataagtgaag agtaagaagt ctatctttag aaacaagaga tgtccaaggc tagaaagatg 48120
gggaaggagg gtggaactgt tctggaagtg ggtctcaatc tcagcaccag cagctctcaa 48180
gactttctag agaaggaaac ttcatttctg aattaaaatt agtcttcaat gacatggcag 48240
ggatttcggc acactctctt gcgtcatagg ccactgtgtt ggaggcagga gtgttggctt 48300
tggaggcata gagattaaaa ttagagtaac acgtgagcac tgaaaaggtt aaacagtaga 48360
gacatggagg actcccgacc cccatgtacc cctttcttaa ccctttaatt aagatcacag 48420
ccctagaaat agcttgcaaa ataattaact actgatcatt tataccttag tgcttctgtg 48480
agcatgtttt ctctttcatt gctgctcatc tgcatggaaa aatgtgcatg ggtttctgaa 48540
tataactcca tggtgcttgc ttccattata tttgtgccat ttggatcata actgataagc 48600
aaccaaagag tcccatatta ctgcacgttc ccatcgctat tttatgtgaa ggtggtcctg 48660
ggggctgttc tgaattctca gtttcctttt ttcccctccc cagttctttg aaaatatcag 48720
aaacggactt gtggcatctt tgaaaagcta cttaaaatgt gctgctgtgc tctgaacttg 48780
aaaatgtgct tttaatacaa agtttgtgca gcccttgctg ctcatacgag atgaatctta 48840
ccatgtggtg gatgcccgtc tcatgccagg cactgtgctc taagcccatt ggtttatttc 48900
agtgcttgaa attggctttc gagagaggca ccacggttcc ctttttacag gagaggaaac 48960
accagaggat cagagatgga gagtctttct ccacaaactc acagacccca aaggcaagct 49020
cagggttgtc agcttccaaa gtctgcctgc tccaggacct catgttgcat ctccattctc 49080
ttcactgagg gtcaaatgga aagaacacat gggggtcaag tttcagaaaa taagagaaat 49140
gaagaaatat gtgcccggaa gcaagaacga ccgacctcat taaactggct cccttcacct 49200
cctctcacat ctttttctgc cttttggcca agttttctct cccccgcatt tcctccttga 49260
tctcgtttga atcctcttcc ctggtgaagt catttaggtt caggctctta ttttactttg 49320
gtccataatt tagatcgaac cacatgtgct gatgtgattg aaacgatgtg gaattctctg 49380
gacagagata gaattatgga ggggttagtg tgtgtgttta agattaaaag accaggtgta 49440
tgggaggaaa tataatgaac aaaaaatagt attttaaatg aatactaaac ttgcactcat 49500
ggaaaaagtt ctcttcccat gaggttctcg caaagcattt taccatcagc acacgcagtt 49560
tttctcagtt ttctgagatg gggccatctt gaatccaaca gacaacacac agcatcagcc 49620
agactaacac aaaggacgtc atgggcatgg acgtaaatac tggtgtcaac actaggtctg 49680
cacctcgaga ggagtggagc aaaaggatgg agtggcagat gaaggtatgc tgttcagaaa 49740
ggaggcagaa atgaaaggaa gaccatcagt gcgctccaca gcttgaggac cgtcctggag 49800
ggcaaatgcc agctgctcac ttctgaaaag aaaaattcca gtgaaatgag tacagtcatt 49860
cttaggatta ctcacttgat actgtgtatg tctcttcttg gcttctcatc tccacacaaa 49920
accctcaggt ggtaaaaatc taattaaaaa aattatataa agtcttgtag atttattagc 49980
ctgaacataa tagatttttt ttaagcacgt taagtcttcc atggactaaa agaaaacttg 50040
taaacctaag agaacctcta tttttgatat acaaaataat acatttcctt aaactatgat 50100
cttgatacta gaattttaat taaaaaatac ctgcagttta tatgcaaagt tatagattaa 50160
tgcttaaaaa taggttgtat gtagtatcca caggtcatgt ttgactgtca aatagatgta 50220
attttaattc ataataattg tgtcgtgttc ttccccacta gaagccaatt atgcaagctt 50280
caccattcac acatggaaaa taatttaatg gagtactcat tgcaatttca cttatccaga 50340
attggctgtt gttctcagag cagcttgtgt tgccttgtta aggagaatat gttagtatcc 50400
agacatccag aaaggatcct ttactgtttc agagtccatt ttccccactt ttgaaataca 50460
cacacaaaca cccattcatg caaaccaaac agagattgta aagtgattcc actgacattt 50520
atgcacttct tttttctctt tggttcttca aactctcagt cagtgcgcat ttactcttaa 50580
tttagatacg gtttaaacct aattagaaac cagaagctct tgtatttcca caaaggatta 50640
tgacagcccc aagaaaagat agtgaaacca ttatataaca agataaaggc ttcttaacaa 50700
tacaaggatg gattttctca ttgatcttag ccttctgaat tttagaaatt gccatttcaa 50760
agtctaaaac aaaggaaaat cagggaataa aagaatggta agtagacaca aacctactgg 50820
ctccatcatt tctgttttag caaataacct gccacatata ccaatagccc aagagatggg 50880
catgtccctg catttcctgg tcaaggtgac aacactgcgt cctcctggaa gaggtctgcc 50940
actcaccata ccacaaacca aatataataa aatcagaagg cacactatag tgaatttttt 51000
agaggcatgt attgaaaagc atctcaaaaa gcattctcga agcttccaga agtcaactca 51060
agttatctga aaagtgacac ttttgatgat tgctcgctta atactgggag agccagatga 51120
agattcctcc ccacttcctc agatgtgcaa ctctggaatt tcttagtgtt actggagatt 51180
cctgctgcat tctgggcctt taatgcataa acactgagat gttctaagga aattactccc 51240
tagggaggag aggggtggac gaggagtaag ctttgctggt gactcatgcg ctgtgtggaa 51300
actccctgca caagtgagct gcgcagggtg agtctaaagg gttaatgcac tttcaaaagc 51360
ctctaatttg ttattccaga agagtaattt actcactaga agtatctggg tggctactaa 51420
cacatttgtg tctttaaaaa gatcagtttt attttaagat taaaaatata aagcaagagc 51480
tggaaagtca ctaaaaactg acagccagtt tcccattttc aagagtattt attaaaaggt 51540
tctggttgca gaaggaataa gaaatggctt gagatcatga cacagtgaat catgttgtaa 51600
acatgttagc tatggctgtg aattcaacca gcgatgagtt caagcgtccc cagaaggtgt 51660
tgggggaatt agggacatgg ctgtgtttcc ccagagaaaa gtggccattt tactttccct 51720
cttcactaac atgcttttga catgcatggc agagctgaag gcaaggggaa ggggacaaca 51780
tagtaagtga ctaagtggct tttttttttt tttttttgcc aagtgaagct gagtcatatg 51840
gcctctgtca ttccaaaact attctctacg gctgcattcc tttcgctctt gccttccttt 51900
agaaccctgg agaaggcctc ctgaagcctg gccctattat gtatcctgac aaagataaac 51960
ttttccaaaa agctgcatgt tgtttctagc acagtttttc ctcgcagtga ctacgtgatg 52020
aaagtaccat gcagaggagg tgtctgactg aggcgttcgt ggtgtgtgac agagtcccct 52080
gcacaggaca gccgcactcc cctcttgcgt cctttcctcc catgtttgca aagcctcttt 52140
ccctgtcagc agggggtgtt ctggcagttg acatttctga aaactacagc ctacattttt 52200
aaaaaatcca gtaagtgaaa actaaaaaat taataccgtg gtcataatag tgtggcattt 52260
gataactaat gaggcactgt cgtgccagct attattttca gacatttaca gtcctttttt 52320
aaatacaaag aaatatttgg tgtgaaatgt tccccgggag ctggtgcaag cagaggcgac 52380
agggcaaggg agcttgggtt gtagcctcga attcctccgg ccagggctac cgtcagcctg 52440
cggcacacaa gtaaatcaaa tataaaacca aaatttctgt aagcaaatca gtttctaact 52500
cactgtaacg aattatcttt cgcacatcac agaggcatct cttttcactg tcgagtttgg 52560
tttgcttggt tacaaaaagg gcagttcaaa agctttggtt gctattgtga aagtcagctg 52620
aattccttcc accgtgctgg ggtggggtgg ggttcacgca ggttctcttt tgtcaccagg 52680
ggtgctgtgg attcacaagt aagcaagagg ctcctcaggt caagcctctg gctgctccct 52740
gaggtcagct gcctagcttc tcctcctctg agatagacgg gaacaaagtc tttgatgtgt 52800
gcatttctca agcttgacaa tgatacagct acataaaaac ccatgatttc atatagatat 52860
tccaaaacgt aaaagtaaac catgcatcca cagagacatg gaattacaga actggatgct 52920
gagctggtca cttgggaggc aggcgtcctt gccattggtt tatgcctcag ccccaccatg 52980
cagtggctgg ccaggtgacc taggccagtc ctgcatcctc ggctcctcac ctgcctggtg 53040
ggacagtgac atctctcctg cagcactgct gtcagggtga gggaggtagg gcgcagtttc 53100
agaaaaccat tgggctgcac ctgcgtgagc acagctgcag gagcaaaagt cagaaaggtc 53160
agcaaaggat ttcaggagca aaggtcagaa gaaaccctca aggtggttgt gtctgcagga 53220
aagtgctgtc gtctcctgca atgctttcaa gactattcag aagcacagtg tgaagggaga 53280
gccggagccc atggggaaat gactccagag tgttccacgt gttggaaggc atctgttgga 53340
aaacggacat tcaagcaaat agttgcctgc atagacaacg cagaatgact gggaaagccc 53400
caacaagtta cctactggta aatgaggtga gaagcttaaa gtgagaaccc cattgctgcc 53460
tctttttcac tttaaaaaca tttaagtttt gaattatggt aaaatacacg taagatttac 53520
tactgtaacc atttttaagt gtacggttca gtagtgttaa gtatattcac attgctaagg 53580
aaccaatctg ctacttttgt ttattaattt tttcctgagg ggaaatattt ttaaatttta 53640
aaatatttaa ttgacaaata aaaattgtgt atattcaagg tgtagaacat gatttcatat 53700
gcacgtacat tgtatactca ttaccacaat caaagaaatt aacacatcca acccacccat 53760
agttgccatt gtgtgtgcgc ggatgtgcgt gtatgtgtgt gtatgtgtgc acgtgtgcgc 53820
ctgtgtgtgt ctgtgtgtct ctgtgtatac gtgtgtgtac atgtgtgtac gtgtgtgttc 53880
ctgtgtatgt gtgtctgcgc acgtgtgtat gcatgtatat gggtatgtgt gtacgtgtgt 53940
acgtgtgtgt gcatgtgtgt atatgtgtgt ctgtgggcac aggtgtgcct gtgtgtatgt 54000
gtatatgtgt atgtgtgtac atgtatgtac gcgtgtgcat acgtgtgtgt gtgtgcacag 54060
gtgtgtatgt gtgtgcctgt gtgtgtgtgt gcatgtgtgg tggggacact aaaaatctct 54120
catcaccttt ttagtcaaaa gaacagttgt tttggtttgg ctcttctgtt ttaaaatatc 54180
agaacaataa taatttccca cagacaaaat cctcaatcct caccatcctt ctatttccta 54240
tattcatcat aaacttcatg cttgatgttg aaattgtttt ctgaaaatag agaatacaaa 54300
gaggagattt taaaatgtca gtggcagccc cacactcctt tttaatctta tttcctgata 54360
tcttgagttt acttggacgt agagttttcc ttgactatgg ttatttctgg tagtagcagc 54420
tccagattag gcaatggttt tcttcagaga tagcttagag tgagccccag aacaaggtca 54480
atgcgaagat tgcttgtgtc tgcgtgtcca gggcacagtg atcctcatca ctagccgggg 54540
ggctccgtga ggatctgctc ctggtcgttt ctgttctgta tcttctctgc agcccttact 54600
gaagccgtta ccaactggca caattcaatt cctactgtac ccatcatgca cagatggctg 54660
aagtattgag aacgctccag tgaccgggag gcaatagtct gtccacatct aagaacacac 54720
ttggaataac cttagagaag agagagagag agagaatgca tggttagtag gttatcaaac 54780
tcctatgact tttcacagga aaagccctca tccacaccaa ctttaggaat gtgtagaaag 54840
aagggtcagg gacaggggtg agtggtgggc agagcagttg gagggcacag ggaaaaggca 54900
tctggtcatg tatttggagt aggaggtctt gctttactat tgaattgcag ggacactttg 54960
ggaacagtgt tcacttcttt ttgcaaccat ttcttcagag aaaagtcatg atactcaagt 55020
cttcttacaa agcagtttga ggctttgagt accagactga ttacagagat gagtatgaag 55080
cattattgta gtatttttaa gtgaaattca ctaaatgcaa ataaacctag caaatgctct 55140
atggttaatt tttttctaaa attcagataa ttaagacaat tcattctcct gaaactgctg 55200
ttcatgtaaa aaggaatttt atcgaggtgg cccttgagtg ccaaacagcc tgtcctcagc 55260
tgcaaaatga gtcgttgatg atcctccagc aagggatact ttttagctcg tgtggtgatt 55320
gctgcacacg ggatatgtgc agcaagtatc tgctgagcta ataataaaca gcctcagaca 55380
gaaagacagt gggcacaagg tcatgcttaa aaagacccct tgttctactg catcccagct 55440
ccccaccatg gggcctcaca ggccctggtg accaagcaca tcagacctgg ttcttgctca 55500
gtcctgggag ccacagaacc cagcacgtac tttaccccca agaccagact ccagcttggc 55560
ttttgtcctc ctctccagga ttggtgacct cctaggtcgt gaagctgtga tgagcaaaga 55620
cacactcctc tccattctcc caacttcagg tccctttgac agtgtcagca ggcatttaaa 55680
tagcagacca cccacagcag ggctggtaga tgcagtgaac tcaggaagat gcctgcatag 55740
actctagtgt taaagacaga atccttacaa ggaaccccca tagttaccta actgctgtct 55800
ccagtggtca tagaagtgtg ataacccact aatcatcatt ctctgtctct ctgtctttct 55860
catacacact tacacacaca tacacacaac cttgttgctt aattttcaga gagtctactt 55920
tcagaaaagc cttcaggaat acatcatgta caaaactgag aaattacctg aagtatcttt 55980
aaatttagta aaaagttgca ttgttttttg aacatcacac ttgaaaagta catgaataca 56040
aacatactta ggaaaaaaag ctttaattaa tttaaaaagg agaacaatgc tatatgctgt 56100
atcccacctt tctctgaatg ttacattttc tcccctatcc caggctgcat ctaagaaaac 56160
tcagagggaa tatgctatct atcttttccg agcaatgaaa gctctgggtt ttttccttgc 56220
ttttcagggc acaatacttc tctttcttcc tggttagaca ggataagttc tgagtcccct 56280
ggtatcatca gcttacttct tctctgttaa atattcacaa aaaatcacta actttcatgc 56340
ctcagcaaac ctccactgcc taaaatatag tgaggtcatt catcttcgga caaattgccc 56400
caactacggt gggaaaagaa ccaatgtgtt ggactattta tctaattttt gtttagttcg 56460
gggatacaaa taaatgcata gatacataca aacatgcgta cataatagca gcagcagcct 56520
gtgaaacatt gacaagacct ggagttggaa gaggactttg ccatcctcca gtccaacagt 56580
tgcctgtcac agattagacg actgggatgt gcgcaggcga ttatttgcaa acggccctga 56640
gtcccccagt ttatgtctta attcgcagcc agggctgatt gtagaagcaa atttgcaaac 56700
atgtgcaaga agaaatcaca catcctagag cttggatttc ctcgtttctt gctatttcta 56760
tccgtagaca gaaccattgc tgagctgtta aatttgtctc cttcccctat accagtcttg 56820
aaaaaggaaa ggaagtggag caaagaaaaa gaaattaata aagccggcag atcctaggag 56880
aatcttattt aatccaagct ttgtaaagtt ttgctttatt ccatggcaac atgggtatac 56940
acatcccacc ggctgtttca gtggctcaga gcaggtaagg cctgtgccaa acgccgctag 57000
caggaggaac aacgtggaga cagccccaga ggtggaacgt tggcccttct gtggctccgg 57060
tgtctcagga cctccctaaa gcccagccct gacactgagc aagtttccac cactgttagg 57120
aagaagtaga aaggaatttg gagggttggt gttactgttc aagagctgga aggcttctgc 57180
ccccattccc attccattaa ttgcgtgagg tagagaactc atagaagata ggaacacata 57240
tgctgatttc caaaattgcc tttgtatatt ttcacgtgaa gactttaggg gcaaaagaaa 57300
agaagcaagc attttgaata tgtgtttcaa tttgccttct gttatataaa attgtatttt 57360
gcctattctt ttttcattat tcggaacctt caagaaataa attaagttct ctcaaaaatg 57420
tgttttttga aaagaggact aaaacagatg gcctggctgt gttaaacaca gggaccagac 57480
cagcacccac ctctccacct gccctgcctt cactggcaga attgtgatcc atcatgttct 57540
ctgttcaatg tcatcatccc tttcagagca tgggtctctt cctttctagg cagtcttacc 57600
aggatgcatg ggtgtgcctg cgtaggcaca cgcacagctc ccaaggactc taaaaaaaga 57660
tatttttctg cttatatact aataatatgt tagagattta tgtttcaaat tagtacagaa 57720
tcacatggtt ctctccaaat tatatttgag agagaaagaa tagaacaaaa tttattttac 57780
aaaaatactc agtacattta gggcatatac aaagatgttc cagaatgtag cttatctctt 57840
taaagacaat taacacagtt tctgggcaag gcaaggcaaa atattcagta acttagcaac 57900
accaacagaa gacagccaat attgcagcac atttttctct tggattgggt cagagagtac 57960
tgcagagaaa atggagtaga gagacctgaa atactttcgc acacactgtg gtcagtgcag 58020
cgtccactgt gtgccacagt aatactagaa actccctggt taggccttgg aatccagctc 58080
tcatttcgta tgtgacctgc agggaagtaa gttaaatgca cacgttttat caagttcaaa 58140
tgcaaactta attttaaatg tatgcaacat cagtttaagc gttgtagcta ttactagcaa 58200
ttgtacctat tactagtctg tactctgcac aactttggag tatactgcct actcaaggtg 58260
gattttagag ctctatttgt ggcattatat cacggacaaa agcacgttca tcagagtcag 58320
aggaatgtgg tgcaaatccc agctgtccca cttaccagct gtgggacttg agtaagctcc 58380
tgaagcagct gcacctgcat tttctggtgg gcaccatgga gctgtcagca gtgctttcct 58440
cagagggctg cgggctggat gaggtttgct ggtgcatgtg aagtgtcaat cattgctctc 58500
atgagtggtg atgctgatgc cgttcccttt tttagggaag tgattttccc ttacaaagtt 58560
accaacagtt tcatgttggc ccatttttct attaattgtt tccactaata ggaccaacag 58620
tggtagtccc atcattttat tactgcttgt cgtagcacaa gcagttgctt cattgtgttt 58680
agataaatat tgacggctgc ttttaacagt ctgctgtttt gtctcctttt gaggtcctta 58740
aagtaatcct taaaaagata gtgcagatgg aaagatgtct ggagtcagtg aacctgcctt 58800
ctttcctgtg tgcttgtcag tttctaaaat gccatacaca aaggactttc atgatttctt 58860
tttaggtaca tgattacagt tcaattcact tcactgtctg gaaaatttcc ttataatcag 58920
gatgaaattt ctcatgttag cctttcacat ttcactactt ttagataagg aattctcagg 58980
ctttgctata tctgactgct cttggaggct gagcttttgg ctaactacct gactactttg 59040
tcgtttctct tcccttggaa tgaagcaaat atctaacttc tcactcattg tttctgctat 59100
tttaccattt agtcatctgt gatttttcta aatactgaaa gacttccctc aattcaaact 59160
atgtgccgga tcaaggaaag ggcagttgga tattgcagac agcatagtgc aattgtgaag 59220
agtgtctgct taccagccac gctgccttgc acaagttatc aagcctctca acccacttcc 59280
tcaatctgta aaataggtat gagtgtagga ccttcccagg ggattttttt gtgactatag 59340
aatgattctc agaagacttt caggcagtat gtgggtgagg cacatgctgg aaaggcttct 59400
gcaggtgcag tgatcaatgc ttttctcagt gtgtacatcc cataatacag acacgttacc 59460
agaaactccc tagccaggac tttgattgca gctcacattt tgtatatggc ccatagggaa 59520
atgaagtgtg tattttttat aaagttcaag tgttaactta atttggaatt tactatcaaa 59580
tctcagttgt tatgggcatt tatagctatt aatacttcgt cccatgtgtc ccatgaggaa 59640
accaaggaac agaaattaaa gttctttctg gagtcccctg aatctcgttc ctgttctttt 59700
gcaccctgtt aattacatag agacattcac agctcttctg accttatcag cgttaaggaa 59760
aacagaaaac cagcgtgcta tttgttctgt cccttagtca agccttctca acatatattt 59820
ttcttccaag attttgcatg tgcacaggga tgcctatcct ctacaagaaa cacattttag 59880
gcaaattata attaaaatgc tgtttacatc tcttcacctt tagaatttaa agaatgatca 59940
tttcttagat tgcatctcag acacaccctt cccctagtct ggagagggcg aggcccatgg 60000
gtactgcaaa cagcctgacg ttgtcagggg cggtctcaac ggctcattca ccacatctgc 60060
ctcgcgaagg ctaagccatg tgctgttacc cctgctgcgc tctggctcat tctaaggtac 60120
acgctattaa ccttgtgaga aaacaaagag gccagcccca cccttcctgc tcactctgag 60180
tcacggtgaa aatgtttcag gatctcgggt tcgaccatga gtcctgtcca ggtccaggag 60240
gaaattcgga aggaccacat gttcactctg agatcccact ttcatttccc tcctggttga 60300
gcagcattaa tactctggct agatttaaat tctggctttc tccagttaga actgaaagtt 60360
atgacaatgt aatcaaaata gaatgtgggt ttacagctgg ccccctggcc tggtttgtga 60420
acataaaaca gaaacagaaa gtgtaagtgg tgacatcata ttctctcatt caatgtgaaa 60480
ggccaccgaa gtctttccag aattattttt gagaataata tgaattttta aaaaatacct 60540
aattatttta aatatcgtct tgcttgctcc ccaaatacct actgttttca acttggatat 60600
acgacatgat taaagaatat ctaatatttg ggaatgcata ctttaacctt ataaactacc 60660
actgtaaata gacagactca ttaaagtgaa aggacatttt aaatcaatta gtaagcaaat 60720
caattaggtg gcaaagacaa gattattttt ccttatggta gttgaagaat aatgcttaac 60780
ctgtcattct aattaccaag cacggtgttc tctttggaag atcatttcaa caaaacatta 60840
ttttcatcca gaatttgaac cttgagattg catggtattt tagaaatcta ttttagaaat 60900
ctttggcaaa ggttactatt aaaacaatca cattcatgga aaatcagtat aagagcaact 60960
aaaataactc acaataccag taaaatcact ttgtcatctt cttaagactt ttaaagagca 61020
tttgtaagta actgaataga aggccaaagg gtgtgtaggt agcccagacc atcagtgggc 61080
agccagggcc agggcagggg ccacggttgc agcctgcatt cttctaaagg gcagagcaaa 61140
ttaaagttga agcaggagct aaaaaaaaaa aaaaaaatgt ttcaaagaat tccaccaacc 61200
agaggatact acctaggaca gtttgggcct aacttatctg tgaaggcctc cagcttcctc 61260
cacaccggtg gccacttttc attcactctg aacccttctt tgtatggagg tcattttatt 61320
aattgagctg tgaccaacat gacagaattt cctgttttag ggcttttata atatagatag 61380
tttatatcta atttcagaat atattcactg gggaatggac ttagcaacca ctaccacaac 61440
aatgcaacaa tgtgttttgg aacaaattta ccaatctgaa tttcccccta gattaggtca 61500
caggaacatt gcagctgatg tacagctatg ttcctcctga aacttggaga cacatcctct 61560
tgagctgggt tataatgggc cacccaaagc tcgagttcct gtaatggata cactcaggca 61620
gcagaaccta ccaccgtagt gaggacagca cccagagccc tcagaggcca tcacaagtgc 61680
accacagctg ccttctctgg cacgctcaga gctacacagt gtactctggg attggaactc 61740
tttatttttt tttcagttga tttgtaaata agattgcaca aaaatccatg cacatcaact 61800
ctccaaatca gaatttgctg agctaaaaag agcattaaat tagatgggct ggctttcaag 61860
gggtgggggt gcaatagtgg aactctgcac aacagttctt tacaaagaga caagcaagca 61920
catcgcgtgg aaatttccat tcaactggaa atgtccaagc ctgtttacct caattaattg 61980
tccttgttca cttgtccagc ctagcaattg tccattagta atttgttata aatgagacat 62040
ttggtattaa agcatctctt tgggatactg gtatggttta ttataacatt ctgttagtag 62100
tgttgtacaa gcttgagatg tattaatacg aaatccaagc tgcatgaggg ctttattttt 62160
caagcctaca ccttgctgaa attctgaatt aaaatatgat tctcagtaca aatgaataaa 62220
tcaacagaaa tggtaacgca tgtcaaatat tcttaaaacc caagaaagcc ttgtaacttc 62280
cttcaatcta atgggaaatg caggcaaata caagactgat gtccttgagt tttattatca 62340
agactcaagg gcaccagtaa aatctagttt cattggttgg aaaaaaaatc ctgataagca 62400
ctgttaggca tattaacttt aatgattaca atttttagga cactctgtgg cctagactta 62460
gaaacacaac taatgtccag aaaaagattc ctctttttat tccatcatct gataggccta 62520
tttttacaca tacacaccaa ccaaaagtag ccaagcaaac aaaacaacat actcacaccc 62580
cttcgcctat tatcatctag gtgattttca atgctcattg caatgaaacc tacttattgt 62640
gcatggcacc cacccccact gaggaatact gtagtttctt tccctttgaa cttcattagt 62700
agagcacatg gttcattcac tcctgaagag ttcttcgtat gtcagaatat atatactaca 62760
acataatttc catcagagct ctgaccaccc gcttatctat tttcataatg cctgccactc 62820
catcattagc tgttgtcatg taggctatca ataaatatat gacaaataaa acagttaggg 62880
aatgagggaa attgactagc agccaaagac ctaagccatc ctctgcttgg acattagaaa 62940
actgagttca ctacagtcat aagatacaca aaggcagaat gtaagccata caaaaatcca 63000
tgtcaatccc aatatgtgag tacaactatt gaacaccatg tactaatgga tgagttggta 63060
aatcattcaa tgtcttcatg aggtcaatta cagattatta tttagacccc aaagattcca 63120
aagatggtat ttcggtcaga tcttcatcct ttgtaagcct agcagaaaat atggcagttt 63180
tattgactac tattctttgc tgggtgtggt atttttaaac tgagacatca gtgtgcctag 63240
cacagggcct caagcacaca gaaaaattcc ttgataataa ttaaataaaa tttcagcaaa 63300
aaatatcatc ttaaggctgt gaaattatct tcctgtgtgg ctaaaatagt gaataaaatt 63360
cagcgcaata taaatcatag tacaatttca tcactaaatt ttctgatctt gatcttgtca 63420
ttttacattg gaagtaaaaa tgtgtcctcc tttttttctc tgacagtgaa aagtgtgtgt 63480
gtgttgtgtg cccttttgca caccctgcct cacacttgct ggtctaattc cttccagcat 63540
gattatgata taattaaatg acagaaatgt ttacttccaa gtggaactaa gccagggtaa 63600
ctcagggtag ggcagctgct tgcaccgaaa gaccaagact gctagagaac taggaaacag 63660
gcggtgcaag aactccaggc tctcatggaa gagcgggagg cttctatggg gctgcagaaa 63720
ctctttggtg cttggggaaa aaatgggtta aatgctctta aaaaagaaac ctgggagagg 63780
tagtttccag atgcaggccc gtcttttctt ttaaacagag gcagctccga agagctggac 63840
attgaaccct gagcaggaac tggaggccgt cagcgcagct ttgtttggcg agcggagctt 63900
tgcaagggtg taatgctgca ccagggagac gctatctgca gggaccggtg acgccgtggg 63960
tgtggagggg gaggcagtgg ctggccctct tggggtaagg tacgcccagg aacagtttag 64020
aataacgtgc gcgagtcaaa gggaagaaga agctcctgca gaccttctgg gcactgtgca 64080
gggtttgctc ctgtccaccg tgccgtgttc ctgtcctggg gtatttgggt gtgtggcgtg 64140
tggggagggg agaaggagca aggcggcagg gaggggatga ggaccaccct gtccatggga 64200
caggccctgg gccccgcaca caccccaagc cccgcgtccc gcgtcctcac tgtcctggga 64260
caccccccac cccaccccac cgccacagcc cagagcggtg ccaggaagcc gcctcgacgc 64320
agccgtatct tgaggctcca gccccatccc cagggtacca cgccacgtag agacactatt 64380
tttcacttcg tgtttgtcac tcctaaagca tgtgtgctag ctgcaccaac cctgggatgc 64440
ctcggtgcat agggtttatg tgcgtcctcc tccttccctc tgagctggtc ccccgtgggg 64500
aactgctgcc cagactgacc tgcgtccttc cgcacgtgca ggaaaatgtc cacgtgcact 64560
tgtcagggtg ggggccacac gggcaccacc actgatcatc tgtgggatcg agttactgcc 64620
catgcagatc ccacgtgcag ggcccagtcg ctttggtgag agagtggacg ctgtggtgac 64680
tccacggtct gtggctgtgc tcaggaggac agagagggga catcctgaga tggtttgggc 64740
agcccgcgga tcctgtgcat gtccccagag cgtccacttt ctccatggag cagtggagtg 64800
gcgttgctga gacagaaagt tcaggttctc cactccccat gcagccccca ctcccctgtc 64860
tccggccagg cacgcgtctg gggtggagac tcccggtgcc cggggccctc cagacctctt 64920
tccccacccc agggagcagg cgggtacttc tattccgttt ggcttcagaa gggaaaagag 64980
aacgtaagtt cagggagttc tcgtccattc ctctcccgtg ggccgggcag gcagcaggga 65040
cagccttcag gagccaggag gggctcgagc tgcgaggccc tggaatgagg caggcatggg 65100
ctgaggctgg agggaaagcc ccgctaaggc tgggcggggg cgggaaaact taccaccagg 65160
ggactcgaga tggggaagga aaggtcagaa gaggagaggc caggcacggg gtgtgggcgg 65220
cctgcagagc tggagcaggt gctccgccca gagccaggca tgcacactca gagtaggtgg 65280
cctgtgcagc ggggaagagg ggcgggtcgg cgtgctgctg aagatgcagg agctgcggcc 65340
tgctctgtgc gtgctgaagg tgtggtgaga agcacttaca aaaagaaatg gactgtgtta 65400
ggattgcaca ttttactttg tttctcccaa atacgtgttc tttgaatttt tttccttcca 65460
gggccaggac tggagtgatg gttgagacag gcacgcactg ggtcttgtct gcatttacat 65520
tttgagattt tgttcagcat ggattttatg gcgttttttt gtttgtttgt ttgttcgttt 65580
tcaaaatact gcacggttta tcgtgaagac agggtccttt gctgccgtct taagttttgg 65640
gcccaagaac gtgccccacc ctaggcccgg gcctgctggc ttcatagctc tcatcattcc 65700
cacggaacct taagacctga ggacagaaag gaaggaaaca agcccagtag tccgtgaaaa 65760
tccagggtcc cgccactcca ggtgtctgca gcagagctga acacacgtag gctcttgcca 65820
ggaggggcat ttgtatgtgc tgagcattcc ttatattctc aatatgacgc ctttgaaaga 65880
tctgtggttt gcaaatattt actctcagtc cataacttat ctttccaacc tcttaccagg 65940
ctcttttgct gaataaaagt tttaaatttt gaagtctaat atatttttaa tttttttatt 66000
ttatggatca tactttttgt gtcaggtttg agaagtctgc accaaagtat gtcctgtggt 66060
tttcccttag gtcatcttca acaagtttca tagtattttg tttagatgta aatctgtggc 66120
ccattttgag ttagtttttg cacaagagtt gaggtcaagg ttcttttttt gcctgtgatg 66180
ttcagtggct ctggcaccat ttgttgaaaa catgatagcc aatgtcaaga cttaatagtt 66240
ataataatca ggagcttttg tttctttttg ttttgttttt agtaactgcc agtcactgct 66300
tgtggtatac atacacaatg gaatactatt cagtcttaaa aaaaaaaaaa gaaggaaatc 66360
ctgtcatttg catacctgga ggacattatg ttaagtgaaa taagccaggc accaaaagaa 66420
aaacattgca tgatctcact ccttcatgga atctaaaaaa ttgtattcag agaagcagag 66480
agtggaatgg tggttaccag gggctgggaa ggtgtgagct tggggagatt tggtgaaagg 66540
acatagaatc tcagttagac aggaggaata agttaaagag atctattgca catcatggta 66600
actgtagtta gtgacaatgt attgtataca tgaaaattgc taagagagta gattttaagt 66660
gttctcacca caccaaaaaa aggtatgtgc agtaatacag tcattaatta gcttgatgta 66720
gccattccac aatggataca tatatcaaaa catcatgttg tataccataa atatatactg 66780
tctctttatg taaatttaaa aataagataa aataaatgtt attcacttgt cgtggatgtg 66840
gtggggacag gtgtgggata gccctccctg tacaactagg acccaggggt gatctagtga 66900
cactagccat ttatcaggac gtatgggtgc cagtcaggat gataaagctt ccttttggcc 66960
actatactac ttagaaatgc cctgcaaaag gtgcacatca aagattgaaa gctcaatcct 67020
ggattttaag tgcttcaaaa gtgcacttaa ttgccacatt tttgtcaaac attttcccag 67080
gtagtatttt tcctcatgta aaacaacagc aatttaattt gaacagaaag cattttgaaa 67140
catacttttg gcagggttcc ttgcagatca gaatggaaat gattaacagg gcaattatca 67200
atcatggact tttggcggca gaaggaactg tattgtttgg tacagtctgg gccagggcca 67260
cacaccgtaa cggagatact ctattctgtg gacggttgga gggggctgtg ctgagcaggg 67320
taactgcatc ttttcctaga ctgttcacac tgctgccacg aaggagtctt gtttagactg 67380
gacctggctt tcttcttcgc aatgagtgtt gcagactccc gacaaaggcc aggtggtaaa 67440
gtgtggtgtc tgtgagcgag agcctgagat gcctgagctg acctgtcctc agccacctgc 67500
catcgtgcag aggtgagagc agcccctgaa ttctgcccct cggtctctcc atagctaaag 67560
caaaaccatc cttccgtgct cccaggacaa gcaggctatt accaaatcac ccactaaccc 67620
tgggcgagga ggggccatca ctgcacaatt catcagtgtc tgtgacagga agagattgtt 67680
ttagactggt tttttttttt ttatttgcaa gcttttttct ctctccaaaa cgtgctgtca 67740
gtgtgttcta atttactctg taaggaattc tggagctaat cataggctca caaaaagcag 67800
cacaggaaag tttcccagat aacatctatt tcagtggctt tcaaacattt ttgaccttac 67860
caaagtaaga aatacatttt aatatcatgg cacacataca gctgtatcta aactttcata 67920
atactgcctt tacgatatca ctctgatatt gtctattctt ttctgtttat ttttcttttt 67980
gttccttgtt atgctggttg tgacccactc cagtgatttc acaatgcagg ctgggtggtg 68040
tcccacagtt tgaaatccca atctagggcc ttcctctcac tgtacaaagt aggtaactgg 68100
ggacattagt ggatcagtga tcaaaccaaa gttatttgat cttaccaagt gatatcagga 68160
tgagaaagct gttagagtgt cagatatgtg aaggaacttg ggtcattcct gatacctcaa 68220
agagaaaaaa ggtagtcctt gaacacctcc tacttgtaaa ggatgcacaa tcctacatgc 68280
ccctcccttt cctttcctcc cctctgtacc ccacccctgc ccacattttc ttcataagca 68340
gctttggtgt tttggcttgt ttgtttccct tgtctcctac ctgtgacttt atagcctttt 68400
ggagactcac agcaatagtt gtatttaaac tcagtgggtg gcatccaagg ctaaaaagga 68460
gattgcctag acacaaaacc acccaaggga gaaagcagga cagcatctta ctatgattgt 68520
ttcttgtttc ttcctgtctc ataaggatta ttacccaggg ttttcatttt tttcatttca 68580
tggttcattt tcgctccagt gtagacatac aatagaccac tcgtccctgt ggctccgggc 68640
agcagcctca tctgagaccc tcctgagaca tctcgtgcag ggcagccgta gtgtgtggct 68700
tccccagggc tgctctaaca gatcaccatc cttgccatgg cttaagaagc tgcagattta 68760
tttgcttaca gctctggaag ccagaagtcc aaaatcaagg tgtcagtaga gtctctctct 68820
ctgaaacctg ctgaggatga tgcccctggc ctctccccag cctctggtgt tcccagcagc 68880
ccttggcatt ccttgccttg tagatgcaaa actccgatct ccacctctat cctcacagtg 68940
agttctcctg catgtctgtc tctgtgcctt cacattcctc tctgtgtgtc tgtgtttcca 69000
tctccttatg aggacaccca tcactgaatc agggcccact ctataccagt aagacctcat 69060
ttcaactcca ttacatcttc aaaaacccca ttctcaaata aggttacttc acaagtgctg 69120
gaggttagga cttgaacata ccttattgaa caatccaact gatgacacat agtaatttat 69180
gcactcgttc ttggagacgt tgactttatt tagtagcatt aaccatggca atgtcaccag 69240
catcgctgac agcctgaagc atatgatctc cagaatgtat ttcaatcatc atgttcactt 69300
ccttggtatt ctttagacaa taactcagcc ttgaactcca gtaaagggtt tccctgggat 69360
tttcttcttg actcactcca ctgtggcctc cctcatccag gactgtaaca gacgcctgac 69420
gtcagtggtc tagacctctc tgctgaatgt catctttggt gaatgtctta tgagaaaaca 69480
catggttggt cactcttaga agggcatgaa agcctgtctg cagtataacc aaaacaggca 69540
catggcgagg cacactgtgc gcatgtgtgt acaattaata tcatggtttt aaattatttt 69600
caggccaagg ggagatcttt gctgcatcta ctgaagaaag cgaatctttt tcttcctgaa 69660
aaaaaatggc tacttattag tcgaatttgt gttttaaaaa tatgtgaact aatataatgc 69720
agacatgcat taatgtttaa atatactgga agtttttggt aaaatgaaac ccattgtctc 69780
tgttgattac tttgatgagt caagaagtaa catcctggga atgattggcc agtttaaatg 69840
agtgcctcag gtttttggaa tacaagaaat caagaggaag ggattagaac atataggtta 69900
gcaagattgg gatcctaaaa tacagaccca aatgaatgga acaaaatcag ggaatttatt 69960
aataacaggg tcaaggccaa atcagtaaca aatatcctga gtggaagaaa ggtggtttaa 70020
caaatgcccc tatgaaagat agagattggc ttaccatgat gagatgtaag cccaagttat 70080
gaggttggca cacaaaacca caaatgtcat agcttaaaac aacacacact tcttatctct 70140
gtttctgtgg gtcagggtct gggttctcag ggactcacaa agtatgtttt catctggagc 70200
tccaggtcct cttccaggct cataagggtt cttggcagaa ttcagtttct tgaggctgta 70260
ggactgaggt cctggctcct agaggccacc ctctccataa gcagttctta gcatggccgc 70320
ctgcttctcc aggcccagtg ggaaagcatg tgcctccagg agggctcagt ccattcttca 70380
tggcttttac ctggttaagt caggcccact caggataact tcattttgta ttaaatcaaa 70440
accagctgat ttgggatgtt aattacatct gcacaacttc aactttgcca tataacctaa 70500
ccatgggact gatatttatc atgcatttgg gtcaagttgc attaagagat ataataaagc 70560
tggacaagct tctgttgatt agaagagttc agttacaagg ctacacttgg gaggaatgtt 70620
tacaaactgg aatggtcaga ggatggggaa gacacttgag aaaagtcaag tgacggatga 70680
aggcaaatgt ggatatttat ctgggagaaa actaagagga gttataatag ctgtcttcaa 70740
atatttaaag ggcttttatt aggaagagga atttggcata ttggattttg ccttcagaga 70800
agtggagtcc tgagatgctc ttagccattc attccagcct ccagggctca cctgctgtct 70860
tctgtccagg ttctcggtag cagggcagta cagccccatc cgtgatcttc catagtcagg 70920
catattgtca cactcagtga gcggagagtc aaccgggagg aaggcacagt ttctctggaa 70980
tgacctacgg aatggtacgc tcaaatgcaa attctccttc ccttccccag tccttgtcct 71040
tcagatggta atttaggagc tgaaggtcag ggcaccagca gcctttggaa gcctacagga 71100
caacagtcag cctggctaga aaaaaaaaca atgtcacagg catgttgtgt ttaatcacat 71160
gaaggatatt tgcattgttt tccaactgat gccagcagac acattgtcag tggtatcatg 71220
cctggggtat cagagttgac attgggttgc cccttctctg aggcattcat gtaaatcctt 71280
ttaagtttat aaaacctcca tgtggctcct gcatgcttca tcatttgcat gtgtctcttt 71340
ttccagggga ggcagcatgg ggagcaggat gctggtgggc tccaggtgca gagagcaggg 71400
tgggcgtcag accccaggtc cactgtgcac gccctcttgt agagcccgtt ccgttgtcca 71460
tgagatgagg agtgttctta tctctaaagt attatcatga aaacctaaca atgtagaaag 71520
actaaagcac atgggtggtg cttcataaat agtatttctc ccactttctg aaaactcctg 71580
ctgaagtaac tgcacaagaa tccttgaaca tttagaattc tggttttagc cataccataa 71640
agtcagtagt gcgtggtgga attctgctaa cgaaaattgc gaaggatcaa ggcagagtac 71700
agagctggtg tgtagcgggt accttctgtc tgctggcact aggtatttta cacattaaat 71760
cagctcgttc tcacatcagc tcttttaaaa ataaggaaat gaggagccac agtggcccaa 71820
ctgatgcagt ggcagaagta gaatttgagc ttgtgcagat gtgcctccgt gttttgtctc 71880
ctgagcatgc tgccccaagt ttgacaatac caagatttgt actggaacat tccctcccat 71940
ccccaccccc tagaagcccc tcttcctccc ttagatttga cacatagttt gaaaccacta 72000
ttaactacct tatgagagcc actgtttgtg aagtgctgac tatgtgccag gtcccgtgcc 72060
gtgcaatttt tgtgaattat ctcgtgtcta cagtgcctca caatttctct gctcaatacc 72120
tccatgttac tgccgaggaa agggaagctc agagagagta agtaatttgc tcgagttaaa 72180
gagctggcca ggacagccag gggcttgcac cccggagcct tcatccacta cactgtcagc 72240
tggtatctca accagccatt acaggctgta aaaaaattat ataagatagt ctatggtaat 72300
gcagaaaagt gaggttattt tgctcccttt ccctttgaag aaaaaagccc tggaaagaca 72360
tatcacttga gtatgggaaa aaatgaagct gtggcttttc tgtgagtcaa ttctttcctg 72420
gcagcttctt ggaataagac caagtatagc agcagagttt tctgttttaa tttgagctgc 72480
agggtgactt tttttcttct atgctttcat ctctctgtgg cttcttttgc ctcgttaatt 72540
tcatgccctg cccaggcggg ctactgtgct gcccagtcac ccgggtctgg ggcggccacc 72600
gctggccagc aggcaggccc tccagaggca gaggtggcca cgcttaggtc gctcccgctg 72660
tggaggcggc acacttgggt ggcagcacag ctgtgatgtg gcggcagctg gcagccccat 72720
gggaaagatg tgtgaagtgt ggggtttgac gacccatggg agaacagact ttcttcctct 72780
tcttgttttc ccttcaaagc cgtgagtcaa cctcaaattc tctgtctttt ttctccaccc 72840
cctcgtgcct ctctccctca cgctctgcat ctctcattgc aagcttgcat ttttttgcac 72900
acaacactat cttaatattt ctcttttctg caggcaggaa atgagaagtc atttttcagg 72960
gtcattcagg aagtcatcca gagttataat ggcccattat ctactggtca gagtttactt 73020
aggctttcac tacttccact gcccacttga aacagggaaa aatattttcc ccccgcgctg 73080
tgagtgtgct atttagagct gaccacaagc ggggggaaga gaggatggct cggatgctgc 73140
atttccactg agaacacaag gctggcaaag cttgtctgct gcccagcaag cacttcaggc 73200
tcacaccatt ttaggttcac tttaagtagt ttctcaattg ttaaaaaaaa aacaaaaaaa 73260
aaaaaacctg tactctgagg atatgcttat aatcccatag ctaacccaga atttcttaga 73320
gaactgatca acatcagcag tggcacttac tgaaaatgca cattctcagg ccctgcgtag 73380
ggcctactga gttagaatat tagagagcag gtctcagaaa cattctatcc ggcagtctta 73440
ttctatgcac ccgaagggat aagagccatg ctttcatgaa acatgggttg tgtgtaaaat 73500
gtttaaaagg tatggcaaaa tgtgtttgat tggcaccaag gatttctggt tcctcctaga 73560
atcattaatc aaactttgaa ggagaaataa gagagtcggc attttcttgc acattctttg 73620
tgatgttgtg atgagttgga aacttcccga ttgggtttat tagagcatga acacccaggc 73680
acccagcttc tagccagccc tgtcaggcag agtctcctcg aagatgtgga aaggactgac 73740
caacagctga ggcctacagg aacctgagca ggcaagggga gaggcacccc ggaaccagga 73800
gcaatggcct tcccaccctc cctcgtcctc tcctcttctc cttttggagt tgcaggccac 73860
agaaaggaag tgacatgagt cactttgggc cttcttaatt ccttcatcaa aggcagcaca 73920
ggtgtgtatg tgtgttggtg gctaattgag gtaggcccac agaggagata acagatggac 73980
atactatttc ctttcttcca ttctgatata attcagggta taaacacaca cacacacaca 74040
cacacacatt ctcacttctt tggcatctac cacacctgcc ccagtgccca tttctctccc 74100
acctgaataa aaagccccca caaagcctga ggtacatgga aaggagcagt ggtctggctc 74160
ccaggagtgt gagaagcagc catgttttca gaggctgtat tccacttgga cttggcccta 74220
cgctgaaggt aggagcggat gggggaggcc cccttcgcac aaagagcccc atgaaagagt 74280
gcacagtcca gtctataaaa cagacgcaga aaatgtgtgt aggacttctt cctgaaaaag 74340
agcgtggtgc gtccagtacc tccatgttca tggaacttcc cagtctgcag tttacccttt 74400
tgtgcaactc ccttttggta aagccctggt cacacttctg gttgttcaga ttatacaggg 74460
ataattccag agtgatttta aagtcaactg ccaggcatcc gcacttgcaa attagatgcc 74520
tggcacatgc ttgtgttaag gtaataattc attacaatac aaattacagg ggagttcctc 74580
tgggcatgcg acctttcccg tcatttggct ttccctgtga ttatcagggg agcttccatc 74640
gtgctgctaa tgggacctta accatgtgtc aacccatggc tgtaatgctg acactgtttt 74700
ctttctggaa tgaaaggcct tcgcaattga aaccaaaatg ttatccaact cagtcctgtc 74760
cctttgacga tgaaaacatc aagttctgga gactggccat ccagcctccc tgcctcatct 74820
cccacgccct ccatcatttt ttgtctctac ttacttattt atttggctgt attttacgta 74880
catcatgcaa aaatattcct ctttgtaaaa agtataatga tttcaggaaa ttagagggta 74940
aaaagcaaga accatgcttt cactccactg tcaagagttg tggaagaatc cttccagcat 75000
tttttctgtg tattttacat acatacaaat atatgtacaa ataaaggtcg atcatttagg 75060
ttttgtttat atttttgtat atatgagctt atgtcattca tacatattgt tttgcctctt 75120
gctttttttt aacttaattt tactttgctt gagagctttt tgaactgaag tacgtgtaag 75180
tcagcctatg catgtaatgg ctccctcatc ttctgtgagg ctgtcactaa aaaggggatt 75240
tagcttgttc tgggctttgc agcccgtaca ctgggcactg ttcatacgta cttctctgtg 75300
cacgcaaagg agggcttgct agggaggcct ggcagagggt gccattcaaa taggattttc 75360
aatggaggaa tttttaaatt ttcagttatt tgaataagtt ttaatatata tccagaaccc 75420
caaatcatca agtttgtttt cttccacatc tgtccttcca tttctgaact attttaaggc 75480
cagtcatgtc tcatccaaga aatcccatcc tttcacacaa cactatctcc gtttcatggt 75540
tatgaatctc taaaagcatg atttttaaaa cataatcaca atgctgtcat cgaacttaaa 75600
aattagccat aaatctctta tgttacccaa caaccagcct actgacacat ctccagttgt 75660
ctcaaaaatg tgttttccat tgtggtttgt ctgaaacatg atccaaaagt cagacccacc 75720
tctcaccttt ccctaacctg ccggagccca tgtttctttc cagccaggct tggagaccac 75780
cacacgggat ttgcttcttg gggcctccct ctaaccagct atgcaggatg ccctctttcc 75840
tgtcaataca agctgctcaa aggactcatt cagttcaaat tcacctatgt gagcctaggt 75900
gatgctactt atttatttat ttatttattt atttatttat ttatttattt attttgagat 75960
ggagtctcac tctgttgccc aggctggagt tcagtggcat aatctgggct cactgcaagc 76020
tctgcctccc gggttcaagt gattctcctg cctcagcctc ctcagtagct gagattacag 76080
gcacgtgcca ccacgcccag ctaattttta tagttttagt agagacaggg tttcaccatg 76140
ttggtcaggt tggtctcaaa ctcctgacct cgtgatccac ccacctcggc ttcccaaagt 76200
gcttcatgtt ttcaggagct gtacgtgcat ttttagtttt gatgaccagg tcctttttct 76260
gttttttaaa gaacttcaaa tgatctccag ggtacacagc gcttgtgtgc tgatgaaaaa 76320
gctggcagta caaaggccac cagccaaggt cacacagcca aaaagcccct gacctcgggc 76380
cccttcccag accctgggtc ttttgctgcc acatgaatct tcttcaaggt cctatgtgta 76440
gattttcttg acttggccat attatttagg attcagatat aataacaaaa tagatgttaa 76500
agcataacat gaaggcattt aaaagggtag aaagcacatg atttactaaa accataaatc 76560
ttatgacctg aaagtttcac ctaatctctt aaaaaatacc gtactaaacc ctgattgaaa 76620
atcagagctc agacatacag cctgagatgc caaaaaatgg ccaggcttgt ctgttgagaa 76680
agccatatgt aactaactgt ttggaaattc aaaatatatc ttatcatttt aaaaacatct 76740
ttcttctaaa gacaatcatc ttggcttcag gaatgaggct agtaaaaagt gaaatactcc 76800
tacttgtgga agaaatcctc attttaacca tgaagaactg aaaaatgcat tctgatgttg 76860
atggacccaa cctatatttg ggtattttat gatgtacaca atatactttt gtatatgaga 76920
ttgttattaa atgtgacttt gctttttcaa gacatacaat gttcctccgg gggtcaggca 76980
ctgtgtttag cactttgtcc tgacctcatc tgacttctca gctgtccctg agaggtacca 77040
gtgtgcaaga tcgctgagtt ggcaagtgat agtgacaata ttttcacccc aatttctaat 77100
ttaaagaccc cgatttctag ttttgttttg tattggattt gcacaatttc acgttctgaa 77160
agaggatgcc ctcaactttg caaaatgggc cttttgaatg aaaaggatca gtcatgtcag 77220
gaaaagcgct acaatgatga aatatgataa ataagtcagt ctttcatctg taattatcta 77280
ctatggggta aaaagtgatg aaaactacca tcttgaaagg ttctggtgat agtggttcct 77340
aatgcagtga aagatgtgta agtcaaagat ttgtaaccag ccagggaatg agaggcgaag 77400
ccatagctgg tggcgggggc cacatctggg tgtggggagg ccacagttgg gttgggggtg 77460
gggcctgcag ttatccacac ccctcccacc tcccttcgac agtacaggct tcctggttac 77520
cttccagaga gtaaggccag ggagagttga ataagttgag aaatgtcatg tcgaagctat 77580
tggtggaaag agttccatta attgacaata caagtcccta ctacattcta aaatctggtc 77640
ctgactagtg gcaagccggg cccaggagta gcacttaaac aatggcaggc ttgtgttgct 77700
ggcaggatac ttcagcctca gaggagctgt gtgcagctgg ggagactcac actcagagga 77760
tttcaaagca gagggcatct cgtagagcaa cttatccaaa ccctgaccca ctgtaaacac 77820
acacacacac acacacacac acacacacac acacacacac cctgagagag agaaagagag 77880
agagataact aaagagagag aactaaagtt tggcaaaata atacatgctc taatgaaggt 77940
ttattaatga ttaatctact cctagcattt cctagtccac tctatctcct taaaaaaaaa 78000
ttctggttgc agcccactaa cttgattgta cagctgctta atggatagca ggctgtaatt 78060
ttcagagaac tgtttaatgc gggctacctc tgttcttcca tgctgcttgt ggttcctgct 78120
ctgctcagga cagaatgggg aggaaaacag gctctgcggc acaatattgg caagtgaaat 78180
tttgtaaacc ggccctccct tccttttgca tttggtctga aaattcaatt agatgctgag 78240
tcctacaatg tatttgagaa gcccaggagt gccctagagg atgagactgg gtggctccct 78300
gtcaggttga acatttgcct taattacttt ggcaagattt gcatcagtgg tattagtccc 78360
tgcctcactt ggaggcctgc acttaagtgg ccacattcag gctccaattt cctggtgatt 78420
tcatagtgta gggcacttgc aatcaaaact aggcttaaag cccaaccctc ttacatttta 78480
cccaccccca caaatgcagc aaataaaatg actctgattt tcattcccta gacctctttt 78540
ctatatttat tacattattg ttaagacagt ttttgaagaa agctgtttta tttaacaaaa 78600
tagctttatg gaatcaactt catatatctt ctccgccaga tcaaaacaag ctcgtagtat 78660
tagatgtcac cgagcaccat gacaggcaga tgaacatcat ccctgtgccc ggctaatgat 78720
agctcggcct gccccggcgt cagccgctcc tggcagggcc agcgggcggt gtgggaccgg 78780
caccgtatct ccagcaattc gcagataaca aatatggttc tgatgatgtt actaaagatc 78840
tgtccctttc aagattggat tagacattag gaatttggag ggctttttat tgctagcatt 78900
tttaagaata accaattaga gtattgattc taaagtctga aagccacatg gacagagttc 78960
atgtaattgg ctactttatg tgcctcttcc tagattgccc tgcattttca aaacaagagc 79020
ctttctattt taatcaaaag aatccagaat gaaatgaggc tttgaaaact cagcctatgt 79080
ttgtcttgat ttccttaact gacatctaga agaaaatatg agctcagggg tccgctgggt 79140
tccttccagc gcctaagcct gtaagctctt cctgctggaa ccaagcttta aatgcacttg 79200
tcagtcatgt cccatgagaa tagatactgc cttccatgtt tttttgttct gatttccgtg 79260
tttgaaatga tgaaaatcat ttttctgtgc tttttaaaaa tggaattgct tttgtgttgg 79320
gaattgtgct gttcattttt actctacctc gttttggaat cactaatgtg gccaatttat 79380
agccaaaaat cagtatcgta gagtgagcaa tgaatggcat ggtgactgtg tgagcgaatt 79440
catgccctcc ctccccaccg ctcgccccgc gtctcagtcc tcagtgatgg taaacagaat 79500
gaggaccttc tcccgaccgt gatgcgcctc agccctactt cccttgtcct ttcctatcat 79560
aaaatcttct ttcatagaaa tggtcatttc tgttcatatc tgtggactgt aaataacaag 79620
gaagtcattt ttgaggtgaa aactgcactt agactcattc caattttgat ggaaactttt 79680
agctggtgga tggcattttg ttttgtctta gttttgcaag gagttatctt aatttaggga 79740
gatgaaacta gtctgtgatc cgaggtctca cttccataca tttctctcgg gcagtgtggc 79800
tgcctgaatc atgcctggat gccacaggtg cttagccagc tggtcctgtc gtaactgtca 79860
ctggtagctc agggagtgca gaggtgccag cagacactat gaaattggcc tcgtaaagca 79920
tcagttatgt tgtgatggtg gcaaagctgc aggcgagatg ggaagtgcag ccactgagaa 79980
ctcacagtag agcgtgtgta acgtaaaaag atgaaaccca ttgtacacag ctgtgtactg 80040
cctccttgaa gtcaaatttc ccccattacc aaggaaaagt tttttctgaa gggggctgct 80100
tgacaggatg acatctggtg atatcattta ttcctttgga aatcaatctg tggaagtgag 80160
tttccactga ctgatgagga gaaaaatgaa ttggcttcac ccagcatcca gcttcttatc 80220
ctgggagaga tagctcttgg tctgtcatcc acgcagctgc ctggtgcaag agccaagttt 80280
gtgcagcctg cagagcactc ttcctgagct gtgggctgcc aggtcggggg gcaggggggg 80340
cctcactgtg cagcctcctg ccacccactg atcatctggg gagactggcc tatcctgtca 80400
ggagacgcag ttgcccagac gttttcaagg gcctaagatg taggcagttg atccacagat 80460
ttttggagag tccttgagtt ggagattaca ggtgacctca gaggagggag tgagaacatc 80520
tgggtcatgg gtttctacta ggagtccaca gtgaaaacaa gaagaggaat ttacgacaag 80580
acagtccagc aacttccttt ctaacttctc ctttcacata tgctggatac tccaagactt 80640
tgcatttaca tggacatcac agatccactt tgagagaagt agggtaaaaa gaaataaata 80700
catagtgctt taggtgtatt tctatacatc ttaattgata tgggattaca ttttcacttg 80760
tgtttactgt acagactcta gacagatcct gctcttttgc aggtaaaaca aatatttctt 80820
aaaacctaga aagacccaaa acaatttaac agaaacattt tggaccattt tggaccttgg 80880
cagttaggcc ccagtgcagc agcggcaacc ataaacctct ccataggtgc tgaacccagg 80940
tgatccctgg caccggcagc cttatgtcag ggctctctta tcgctggttt ttatttctcc 81000
taataaaagt gattaaaaga ttcatctttt aaagaaagca aggacacaga ggtggattct 81060
ccctgacgct agcacagctc atgcccaagc cactcctgca gggctctggt ctaagtgcaa 81120
aagctggaaa agctgcaggt cccgcaagac acagagcaac cctgcaagcc aggtcacctt 81180
ccctcttctc tgctgtccga ctggccctcc accatgtgac attcaaaagc tcaagttact 81240
taacctctca aaactcagca tccttttctg tacagtgggg aagatactgg actgttgtga 81300
ggattaagtg aggagagtgg cccaatgagg ttgacagtta ttactgtcat tgtcattatt 81360
tgccttctca caggcaggcg tgccacagtc attttactga agctgcttca gtgggtcctg 81420
aattaggccc tgtcctttgg gagagacagt cctggttcaa cacacagctc cctgcccagg 81480
gcagcttggg agtgtgggcc agtttcgcct ttagaaccac aattctctga tatgtgcaat 81540
gagagaatta attatagact caaaggattg catgcagaca cacacagata caaacacata 81600
cacacaacac acagagttac acacagacat gctcacaata cacagaaata cacacagaca 81660
cacgcacaca gcacacagag atacacacag acacacacac acacacacac agacatacgc 81720
acagatgggc acacacagag acacactcac agagacacac agatacacac aggcacacac 81780
acagagagac atacacacag cccacaggga tacacacaga cacacagaga catacctaca 81840
acacacagag atacacacag tcacacacag agagacatac atacaataca cagagataca 81900
cacagagaca cagatacaga cacagacaga catacacaca gacacgggca cacacagaga 81960
cacacagaca cacacaggca cacacgtgca gataaggtaa tattagctag ttcaggagga 82020
gaaagagata aagataaagt aatattagct agttcaggag gagtgaaaga agccttgttt 82080
ttctccactt tttatagaag agaaagtgaa gattcgattt gaggtgagtt cagcacaaaa 82140
gcgtatccca ggccctctgg ctccaactgc agccctttct acctcattcc cagaccccac 82200
ctaagccttt tctcttcaaa atcttctcag gcacactgat acacatacct cagattttta 82260
attctccggt tgtgttcacc aggtgcttgg tcatgattaa gaattccgtg atgtgtaccc 82320
catgtgttta aatttgctgc tgagttaact ttgtggcggc ctgtggacta gacctctgca 82380
catgcaatgc agaacggcag ggccagattt gaaatcctgc tatcttttcg gctgccttgt 82440
aaaaataaca tcaggcgatg gggatacgat gccagaggtc acctgtgata agttctgttt 82500
atggccattt tacttctagg aagacaggaa gtgtcaggat ctcagggatc taggaagcca 82560
aaatgttttt ccactctgaa ataaagtgac tgaccaggag ttcccggcca cgcagccctg 82620
tgggaactgc cgcacggcca cttttatgaa gtggacacgt gttggtccca ctgaaaagaa 82680
actccccacc catggctccc tcacgctgca gcagaggccc tgccacagca cctgtcagcc 82740
cctgccagct tgcaggggcg caggcgcaga gcggtttgtg cccttgctgg agccagggaa 82800
gggcacaggg tccctcctgg agtcatggga ggtgcagccg aggttctata ttaaaataca 82860
gaggctagca catgtgcttg gggaatgcag ctacagtagt ggaatgaaag tgctgtccgt 82920
tccttacccc cccagctcct cacctgtcct ccacacgcat atccctggct ccctttccct 82980
agtaaggaga ctgaattgaa attgtggctt gcccgaggct gcatacctgt gctctttctg 83040
aagcccaagt cactggctct agaattctaa cctgtgagga agccactgag gatgtttgtc 83100
aaaatacata tttctgtgcc ttgccccagt tccacggccc aggaatctgc agttttcaca 83160
agcaccccca ggtgattctg gtggtgtctt tgcacttctt caaggcagta ctgcctggaa 83220
cgcagaatcc cagcctcctc tatcctcctt gcctaatggc ctggatgctc tcagatctac 83280
aggggaaggg aaggtcacac agtcatcgca atagtaacct cagctgataa atcctccccc 83340
ataaaactta ttccccagtg ttttttaata ggaaacaata aaactgtaac cagcccaaat 83400
atccatcaaa gagaaaatgg agaagtaaat catcgcacat tcacctggac cagatctatt 83460
gtaaagccaa taatactgaa gccccttcca aggccctggg agtcctaaca gtgcactggc 83520
agtgtctata atttatatta tgaaatttgc ataaggaaaa cattttgtct catttgtgca 83580
atttctcctt ctaaatatac gtgtcacttt gtacctgatt tctataagac ccaggaccta 83640
caaaccctgt gtctgcccct gcagccaccc agggaaggac tgcacagcag caagacagat 83700
tgccatggag catgttgtgc ccaactaggg acagcgcaga tagattctgt aatttgccta 83760
acaatgtcta taggatgatc ccatttgtca aaaaaaaaaa agaactgggc tttattgatg 83820
tcacctaaat gcacctaaac ttcttttttg ccccatgctc ttctgtactc ttgatctttc 83880
cccaaatttt taaaaacatg acactcattc ccttattttt cctacttaga aaagtgtaga 83940
tggttttatc ataggaagtt caaaaaaatt aaaatataat gaaaaatact caaatagtgc 84000
ctcacaacag taactactgc taacataaat aaaatccata tttcctctca tacagacccc 84060
agagttgctt tgcctgacag tgtagttgat ggagaaaata atctttatcc ttagcctcca 84120
tctggttgca gaccataaag acagggaaaa aatgagggtg ttggtagctt cgttagaaac 84180
tgaaagctca ctgatttttt caaaacctaa atagcctgtg tttctccaaa taactaattt 84240
gcagccttcg gcagccagga ctggcaggga tggggctagg gggactgggg agaactgctc 84300
tctcctgagg gtggtctgac ccgacagcac gcatgacctt cccacagtca ggaactgctc 84360
agagacgtga tggcaactcc atagaatgaa atactcttca gccagtaaaa tgtatttttg 84420
gataaatatt tgctttaaaa aactttacta tatgttgtta aatgaaaaaa aaaccttaag 84480
gcatcagaaa ttatgtgcag taaaatctca cttttgtaaa taaatatacc tgtttactac 84540
gtatgcataa aaagaatcct gagaaatata agtactgtat gcatattgtt gttaagtatt 84600
ttttctgttt gcttatctat aattctaatt ttgcttcaaa gaacaagtta ctccggcaat 84660
ataaaaataa aataactaat ttgtcttgtc atcaaacaga tagtaagaac aggcaaacct 84720
ggccctccac actgccagcc ttttgtgatt caaggcttca gtttcctcca cttgttaaaa 84780
agattcaaca aagtagttga aatagtatgt gaaccagtaa accctaaaag gtgtccagtg 84840
ttgtctgtga gctaattaag tgatttgatt ctgactcccc gagtcttctg atttcgaagc 84900
agtggggagt cagacaggag cctcaggtgg cctctcctga gaggccctgg aaagtgatga 84960
gaacctggcc tctggcagct cttcataaac gtccatgttt tccctctact ctctcactct 85020
tttcccaggg cctcaaacag aagatgaaaa tcaatttcta aaacagccct ctgtgtgctc 85080
tctcgtatct ctccttttca cacatcgtgg tggtggcttt ctctgtgttc ctctgttgat 85140
tcagtctctg gaattaacgg atcaggattc catgcccaga atgctacaaa gactgtgctt 85200
gagttctccc acatctcact caattacaca gaagtttcag attatgtaac agatgctgtg 85260
ctgggttagg cagagccatc tgacttgttt tgctttattt tagaccatga gatgggtgag 85320
tttttctttt taatgccaca ttcttttaag aattaaaaac ctccacttgg ctgtcagcat 85380
tggaaatcag agtgatggtg caagccctga tgaggacaat gtccttgtct atgaaaaggt 85440
gaaatcattg cttgaaatcg ctaagcagga catgcagtcc cagatggagg ggggaattcg 85500
ggagctggtt ggaaaagagt atttggcact ttgcagcctt gagaggtgca gaagagacac 85560
cgaggggttc accaccagag ccaccattgt cagagaggcg tccagctgtg tccacctggg 85620
actctgcctt cagggcttct tgcctggctg ggagctgcac aggcagactc ctgggacggt 85680
gtgccgacag ctctgggcac ccccttctag gatctgattc ctgaggaatc acaatgtgga 85740
tttcacaatc acttccagtg tcttttgcca acctctgtga acagatgtgc aattaaaaaa 85800
aaaaaaagaa aggggcccaa ttctcaacac tgtaagtgga aactttttaa tggaaaagga 85860
taggctaatg aattgaattt gaaatctgag acagaaccga tgcatcaaat gtgctggtgt 85920
ttacagataa tacaaggggg gctgcatctt atggtttcaa tcctttttta aatttttgtt 85980
ctgagagacc cagccagcag actgccgcca gtcttgtcag agatgtcagt ggtggccact 86040
ctgaatggaa agcagcatct ctcagcatct ctgaggcact gctcctcagc ggagactgtg 86100
gtggctttgc ctttcagcac gcatcctttc tacgatgcct gacagtgccc agggaatggg 86160
cagagctggg agctctgaag ccctttcacc taaaccaccc tgggtcacct gacctagttt 86220
tcctcccaat tttaattatg tcaggcactt cacaaaggcc tccttgggga caccatgagc 86280
tcactgtcat cagattgctc caatcacagc tgtggcttgc acacaaccgc catctctgcc 86340
ccagcagatg ctgtgtgtaa acagttgtat taattacatc tcaaaaacat ggttcttgcc 86400
agatcctcag gatttgggtg cagcctctga ggtgggtggg aggccctcga gggagaaatg 86460
tctgcaggaa attcttcccc tacgagaggt ctgttttcta agttatctaa gagctactgc 86520
agctgtttac tgcagagtga ccctgctcaa agctgtggtc acccaaggct ttgaaagggg 86580
acctccactt ccgccctggg tggagcaccg tgctggagac ccacgcctgc caaggcctca 86640
ttgtcatctc cacacgccgt ccttggggtg ggccactcct gggacacgca gacaggaagc 86700
cggccacctg agccactcgg aggctctatc cagagtcagc tgccaagcct cacgtcacac 86760
atcactgtta gtcttggagg gctggcgggg ccctgaagtc aattgaacac ttggatgaca 86820
gggaacttgc cactgccaga ggcaatatgc tccatttttt tgacagttcc aacaattttt 86880
ctttaaactg tcataaaaaa ttgctgctgt gaataccagt gtcggcgtcc ctgcctcacc 86940
tttacctggt gcttttccac cacacaaaac tgtttctcct cgtgctggcc ttgggcttgc 87000
agacagctga ttcttctcct cccgcggctg agcagcctcc tccgagcaac cctctgacaa 87060
ctctgctcct tctgacaacc tctgcaaggg ctgccagatg tgaacaaggg gcccgggcag 87120
aaggtatcca ggaagactgg aaactcgagg aagcctgccc tgtcctgtcc accagacttt 87180
acgcttgcgt cactgggctt tgggacctaa gtcctcgtca tttgttcctt ttgcagttcc 87240
tactgttctc agcacttcct tccagcttac tgaggtacac tcagatgtga tatgccatcg 87300
gtacagacac agttctgctc cagcatttcc ccgtgttctt tctgtcgctc tatttactga 87360
attaccgtga ggatgtggag cgaggctgag ttctgtattt taacaccatt ttaattctca 87420
cctactgaga aatccatcct cttatcactg tgcttttttt aacctgtcac gaatccatga 87480
aatcctatca gccagcctgc atacttcctt ttaaggtgca gttgaatcag gagaaacttg 87540
ccgcacatgc tgcgtccggg cacagcattg gctgaggctg ctgccctgac ctgtccgctt 87600
tgtagtactg cccagctatg aaacaggtta gccacacatg acctgcattt aggagtaaca 87660
agtctgtctg tacatgcaca tacagcaact tttttaaact gtctatattt tttcctgaga 87720
taggtattta taatatctcc atcttctttc ccattttgaa acttagaaca agtttgcctg 87780
tcaacagttc tccacagcat actgtgtatt ctaggatttt ctaaggttga gcaacggagg 87840
ttcagcaatt ttgacttaat ttcttcccat cccttttcca cgcagcccag aagccttgga 87900
tcacgtggtg aggggaagag gttgtgctat gtcgggaaac tctgtatcga agctcggctc 87960
agatcatgac attctcttga ctaaaaccct cagtttccat caaacttgtc actctggcat 88020
taaagcctgt cactgtgtgg ctctgaaaac ctctctgaac gtgttccctg cctctgccct 88080
gcaggtccct gtgctccaca gaagcccact tatgtgaccc acccccactc atcaccacct 88140
tccctcaccc agagcctcag ctccccactc ccacctgtaa gacccctact ggaaagattc 88200
ccacctgccc ctcaagatta atctccaagg acatttccaa attcctctcc ccatctctca 88260
gccagatggc tttgctccct ccaggaaccc cagccacctt cgacctccag cagggcactc 88320
cactccacat tctcctggtc tgtctggctc atcttacctg agccatgctc tccaggtgaa 88380
ggactatgtc taactcaact ctgctttaaa agcagctaac acattgctct ttgcatattg 88440
ttcactcact aagttgaact ggacttggac atgcacactg aactgcagcg tctgctgctt 88500
cttggtggcc cagctcgtca aaagaataag atttcagcaa aacaatgtaa caattttttt 88560
taccaaaagt aatgttaaca atatatggtt ttcccctgat gtttgcgtca aaatgctttt 88620
tggaaaaaac atttttcaac tctttagggt cagaattaag caatgaaatt tatataccac 88680
atgtataatg tgtatgttta tctaagtatc tgttcattta tatatcttaa atagaaattt 88740
taaaaatttt tttaaaactc ctgataaaca ttctcaggag gcacactatg taactgttgg 88800
ttgatatacc tagctagatg gtgaaatcag attttgttta aagcatggag gagagggaaa 88860
aattaaatct tgcagattct gcagtcctta acatctttga aagaggaaca tttcagacaa 88920
tgtaataaga aggccacgtg ctttgacttc tgtagatttt aaaaatactt ctgtatagtt 88980
tcttcttcct ttgaagaagt ttggggagtt tgggaagatg gagaaagata taagaataga 89040
ctccccatat gggtcatgaa ttatcttttt gcatcagaac tcttagtgca gtttcagtat 89100
tttcttcctc aggagggtga gctgcttccg aatgtcctcc ccttctttga ggcatcctct 89160
gttggtgaac tttgagagca tccatttatg aagttgatga cctttcccag tctctgcaag 89220
cccttcagtg tgtgtcctct ctgagcaaat ctgaattgtg tgcttaatac atggaaaggg 89280
atttgggagg gttgcttttt aaactgattt cttaattaat attatggttt agttaactag 89340
acagtctcat tgcagaagtg cataaccata atatgtcttc aaatatatct cccttcctaa 89400
caccctgtaa tatacttttg taaagatacc cttacagaat gtgatccacc atttatgaac 89460
ctgcagcatt gcattcagag actaagtgaa aagctggcag attttcattt aaagcacaag 89520
ctaaggaaga aagctggtct agaaggagct acagaagggt aatgcttagg gagggaatga 89580
tgtgcctgtg ggtggtggta gttaaatcta accaaagaat gatgtcgtgg gtgtttggat 89640
attggatggt ccacattggg ccacattctt tcaaacataa gagtctgtag aaatatgacc 89700
tgtaaaagac tcttaaatat tctggaaact gtttcttcct tgtcacatcc ttatatatac 89760
ttgaacctat gcctaccaga catgacatgt gactattcat acagatttca tcatctctgg 89820
tttaagaata aaggatgctg catagaaggc tcacatcttt taattcacaa gactgaaact 89880
gttctgaaat gacattgttt ctaaaaattc attacttgca ttatattcat ttttattttt 89940
ccatgccaga agggtagaag ttcctgtgct catattaaga aacagcaatg tcaatcgagg 90000
cccaactcaa atccaattta taggagttat aaagggcgtg tgcctgtttt gtctagaagc 90060
agtgttgggc agcactgagt aggatagacc acctgttgct accgataaag gagcagcttc 90120
tcgaatgctc ctgtctggta ggcactatcc cgagtgcttt ggcccctcat ccacaatctg 90180
tgtggcaaaa ggcattgcag gcaattcagt gaggagaccg aggcatggag agcaagtgcc 90240
atggaattcc ctaaggccgt gcagggagca ggttgccaag ctgggttgaa accgtcctcc 90300
gtaggctccc aactccgccg tcgctgctac tgtgctggat gatgcctggt agatgcagat 90360
gtggagcccc atggattctg agacaggccg ggtttcagtc ctgccctagc tgcctattgg 90420
ctggatgacc ttggcaagtt gactttcgtg agcctcattt gtctcatctc tcaattaaga 90480
aaacctagag cctatctgtg ggggttatct gaaggattcc agggatgcat atggcactgt 90540
ctaccgcatg cggtaactgt ttcacaaatg atgaggagcg atttatgttc ttagtggaaa 90600
tatgtcggcg tgtgaagtcc caaagctctg ccctgcctgg cttgatccag tgcctaggca 90660
ctgcccctct tcccctctct cccaacccac tgtaagaggc taggctgcct cagtaactct 90720
gaggggcatt gactcttttc atccaaaaat tcatgttact gccccacatt ttttctgttg 90780
ttttacaacg cagtaggaag tgggcagact gtcaggaaaa gtgatttata gtcatgtatt 90840
gcttgtgctt tggcttcatt tgatccaatg cagatcagct gcactcagaa aactactcaa 90900
gtgaaagaga aaaagtaact gaagggggaa atctggatga gtaagaattc cagggatagg 90960
aatattaata gcaagctttt tgcctgatat agtcacttta tgctgcaggg gtgccccttt 91020
ataaagtgct tgtacaatgg atgtttgctt ttgattttgg atttggagtc taatgaatgt 91080
tctaaattat tattagagga gcttgcggtt gttacatgtc tgcctttatt gcttattttt 91140
agccatctcc cctgatgtca aatgctcagg caagaatgat acattcattt ataatgtggc 91200
tccttcagaa atataccaca taccttttgg tgtggtttgt ggctgagaag agtggggaat 91260
gcacaagtgg aaaactgcag aaagattatg ccttcatcac ttcaagtatt tgagatgaaa 91320
ctagatcatt tgctgttgct ttttattctc attctaagtg cttttcaaag tcagcgctaa 91380
gattttaaaa tggttttctg ttgttggcag agagggaatt actctattac tttctgataa 91440
aacagagtct ttcatgatca aagagaacca ggctctagta gttccagtat cctaacgtgg 91500
acactaattg tttccctcct tttcttcatg aaaacagctt ctgcacaaat gatagccttg 91560
tgaactagcc atgggcacaa ctggagaagc atttagggag ctttagtgca aattgagacc 91620
acctacacat ctgactctac agggtttgac aacatccagg gtgaatcaca aaacatcagt 91680
ctaatcaggg cttatataga aagagtgaaa gaactctgat ttcatcctaa agattattta 91740
tattaaccat tgttccaaat gcattaacta ttttaattta gttgttttga ttgttaaaaa 91800
aaacacatct gtttggtaga taagacataa tttaagacaa atgttctatt tgataagctt 91860
ttagaaacaa cttattttta ttctttcctg tgagataact cagatgtgga gaatgtgaca 91920
aaattttaag cataacatga gaagggctga cacacataga tttctgtgtg cttacttgaa 91980
aacaacaaaa tttaagaatt tggtatagga gttgtatcag gtagtgcaga gtccccagga 92040
gacctagaga cccaggtctg ggagcctagc ggcaagggct gaatgtggga tgacatcagc 92100
agaaactcac agccactgct attccaaaaa cccagcagca gctcagtgca gggcagtgct 92160
gatagtacag tgcctgcaat cctggagtgg atttggatgt gtcaggtacg cacacgctca 92220
ctgctccccc agcagtacgt tgaacagtgt gcgtccaggt gtctgtaggg cccctcgccc 92280
taactcacaa aaccattctg ggtcagaagc caccaatatt gtcatcatcc tcccttttct 92340
gagaacccta gtaagtccct ccagtggggc aagcccacct tttcccttca ttctgtggca 92400
atatgccttc atttcctaat cagttttgcc ctgctcattc aatgcaaaat ggatctgctt 92460
tccttgggca ccaatatgtc cagggattgt ttatcaatct tcagttctgt ttcctttaca 92520
tatccctcca aaaatcaggc ctgcactgcc tgtgcactcc acaatccaca ggcctgaagg 92580
aaatgttatc tttgatgtag agacttaaag taaaactctt caaattaatt atttcatgca 92640
aaaggctagt cctgactcta attctaagac atgtctccta aactctggaa gtctgatgta 92700
tcctattatc aacatttatc cttaatgtga tggtttatca tttatcctca aagctgcatt 92760
gtaaaatgta cactgtaaag tgtacatttt aaagtcggtt ttaaaaaatc atatttagag 92820
atcctggtaa aaatctatca agtcaagaca ttaccttatt acccatggaa ttgtcttcaa 92880
ctcttacagt tcaaatattc ctgaattggc tttcacaata aacatcctaa atatgtaagt 92940
agaaacatat atattgccaa ctttgtgcct tcccaagcaa aattaaaata caggaaaagt 93000
cagtttgttt tgcccataaa taaatatatg tgtgtgtgta tgtgtgtgta tacacataca 93060
cactcagaaa agatagaagc agcagcatat tttggcagca tctggtttat tggaactcaa 93120
acgttctgat tgtgcataca gactagttaa tgtggtaaca attatgtatt tcttccctgc 93180
tccttgcctt ctttccctcc ccagtttttt tcttcctgat agtaggtgtg tacttttttc 93240
ctatttccat tggcaagcca catgacaagc aaaacgatca ctcgaagaat attgttccct 93300
caatcaagaa aaatgcccat tgggttttgt tatttgatgt tatttgatga cagagaccta 93360
ttgtttttcc atttttcttt ttttgttttc cgtggcacct atggaattaa gcaatataaa 93420
aaatctatta tttcagatgt tcacgtctaa tgaatttcat gtgaaatact ggcagtataa 93480
ccccaaatag aggaaatttg tgaagagtgg atgctgcagg gcatgagaca tctgcacaga 93540
gttcatctct tccagcatct tgcatgtccc aagcactgcc ctgccaggca gagaatgctg 93600
cagatcacgg cagtgaattc cagttgttca gagcacattt gacttccaaa ttctcaaggc 93660
cacagatttg aggacagaac aatatttgca tttgaaattg gaagattatt ttttgcacaa 93720
gtgcctatat gctatataga gtttgcccac tctgcattat cttccccctg ttcccccgtt 93780
atctggcaca agctattcaa aagacacgcc tacttgtaaa ataaatggtt tgcaaactaa 93840
ggaaaatact taaatctcat gtaaatggta ctatactatg tataaaaatg tgaagaaaca 93900
cagaacagct catgaacacc tccactgctg tataaaagaa ccatcttttt tctggctcct 93960
attggatgcc ttagaaaaat ctgtatttcc tctttagtta ttgtgtttga aagatgaagt 94020
tgagacaaaa gttctattct ttttaagttg gcagaacttc tgaaaggtga tttttagctg 94080
cagtgtgact cattccaaat gcagaaatct ctgaccctga gttagtctat ttgtcatgca 94140
agagcctaga aaagccctga gtgataagaa atggccatag gccattccca cagaattttc 94200
aacaaaaata gaatcatgct tatgttctag tcatgactta gaacttataa ctcatgttcg 94260
gaactgtcca tgttcacgca caggggccgt atcactccgc cagagctgcc ctgggtgccg 94320
gtgtgcagag gggtccgaga gtgactgtct cttcctctgt tgtcgaatgt gtgggttatc 94380
tccataaatg gctgccatga gcatccttgt tcacacattt ttaggtactt gagtgagtgt 94440
ctgtggaata attttgggaa gtgaaatctg tggtcagagg tttgtgagtt ttacatgcta 94500
cattttcaga agttgagaaa tagcagtagg ctgaaggcaa gtcgccatgc ctggaattca 94560
tgaacactag ttgaaagaac tggcgtgagt tagtcatgac aggagagatg gggaagggag 94620
ttgcaggtag gagggccatc ttcaaattct caaagtatag tcactccaaa ccaaaattcg 94680
atttaatctg taggactcca ttctcaaagc acagtcactc caaaccgaaa ttcgatttaa 94740
tctgtaggac tccaggtggc agaataagag gcaatggatg ggtggaagcg aaacagggcc 94800
aaagtttgac ttcatgtgca acttcctaag gagtgatttg aactccacaa acatgaacta 94860
agcacctcaa cacaggctgg gcaagttgct gttcttttgg agcttacatc ttagtgggga 94920
aagagaaatg cctatgtaaa catataaatc agcaggatac attgtgagga cggtcattgc 94980
tcagtgagac tgcaatagag tgatacgctg gagggggctg caagggagaa ggtgggaggg 95040
acagcattta gcagaatgag cagcacagtc ccataggaag aagaatttat tgcctcctta 95100
ggcaaataaa ttcccaaacc ttgaacatca gaaaggaaat agattaatgt gcacagagga 95160
ttaaattatg tgatctgcaa agtcatttaa aatctatttc cacataaaac atattaatgc 95220
aacctaaaca aaaggggtct ggataccctc atcttcttcc caagcatcaa gtctttctat 95280
agttaaactg agatgctttt attcttggaa aattttaagg actatctaca gcaatggaag 95340
aatcgggtgt tgggatgtgt tcccaggtaa taatgactgc aggctgattt ggcccttgag 95400
gtgtggcctc atggccctct ccaaaaaaaa tcaaggacct gctacaaagc acaaagccga 95460
ctgcaatgct tgctgcttac tggttagggc agctcctctt tgccagcgac caagcagaaa 95520
gcaagacaag acaggttctg aagcagtaat tcaaagcctt cctcgctttc ccatgtgagt 95580
cattgctagt cagaatatta cctttgcaga gaggcttaat tccaaatttg ctcttaaagg 95640
gatatcctct cctggtttag gtataaactt ttgactcaca ggacaaattc tatcattcct 95700
ttgggcctag gattgcattt atttccatga caaaagggcc tgtctggtgt ttcagcaaat 95760
gaaaacaaaa atataaagcc catctccttt tgaatgagct ctaaaacagt tctccactgg 95820
acttcagaac aagagggagc tctgggctgc tggctggttg tgcatttgct gtgggttccc 95880
tccggcaggc gacctctccg cgctgagaag gttatccgga taaccaagta agaaagtaca 95940
tgaggaggca cagaaagaaa aatgtgagag ataacagcat aaacacacag tgtatgttgt 96000
tatgaggcat cacatgatga gatactgctg gggagggaag aagtgaggag attcctagga 96060
atcttatgag aatttccaga gacaacaagt tttgagcttt tttttaattt agaaaattta 96120
ccttattttt aaaagaatat gtaacatatc ccatgctata aaattctaga catagtagat 96180
ttaaaacagc ataatggaaa atataaatat ctattttctt ttcctattta tgtattctgt 96240
gccagtagga atgtagccaa aaagagagaa aaggggtctc tgcagacatg gatgtctctg 96300
tgacttgatc actgctaacc caagaagata ataaagcaga agcatgtatc caggttgctg 96360
cagccaagcc tgcccggtct gcggggcgtc ctcacacatg gggcagctct cccaccccac 96420
acactgggaa aggcggacag aggctgggca aagcccccaa ttttcgttgg cactgacccc 96480
gatgatttat aggcctttgt ttcccatgtt aaatgtctta cgatcattaa attatttata 96540
gctcaattag catgtgtcca aaaccaggaa gttcatagga gactgtgtga ctgggaatta 96600
aggagcaaag caactttcca gtctgtgatt tactgggttt ccattctgtt tcctgttcgg 96660
atccggaagt agaatttcaa atattgcttt tcatgcttta tttgggaccg attttagccc 96720
cgctctcctt tctcttgcca ttcgctggcc attagccacc agcctctgca caatgaccag 96780
ctggcccctg gcagatcttg ggcccaggtg tgaagtcgct ggagaagcat ttcagggcca 96840
agatgggagt gatttcattt tccattgaca ctatgcagaa atgaagggga ttcaagtgcc 96900
ttcagaaaag cttccttcca gcgaatggag ttttgggggt tttccagact tgcaactgct 96960
tttattcttg gaagcatcat tgttgctttt tccccccttc catttatatc ccaggaactg 97020
attcagaaac catagaaatt ggatttggaa tcgctgaatg ctagcagaca gctgactgca 97080
ctcttcccaa gaaaccctgc cagctgggtt cgggtatcgc gcggtgtgtg ctctctctgc 97140
ctggcccgct gagtcctcta actctaatgg attccttctt acaccaaagt gcactagaac 97200
taaagtgttt tgcttcattc tttagacatt ttgtggttta gggctcaatc agccagggta 97260
tgatttgcaa tccacagtaa ccggtttcag agcagctgcc cagcgaggca ggtttcatct 97320
cgcttgctag acgttttgtt tttttttttt tctaaacctc acacctttta tttattagac 97380
ttggattcca gtttcctgag cctgtttgtg ccactgatta gacaggcttg aagcagaacc 97440
caccaggctt cctgaataaa atgcagcagt gattgtatta gggggtttta aattgctcaa 97500
aatactgtct aaaaaacact aaaaatcatg ttactttcta gattgaataa aatcctatag 97560
aaatgaattc ctggacttga tatgtagcaa gctggcattg gctcgggagt gagtgggctc 97620
agttaagtga gctaagatga gatggtgcac aggcgagcac ccacctgagg agtgtttgga 97680
tgttatgata gccagctcct ctgtaaagac ctgtccttct atgtcagcag cccagcagat 97740
aaatgacgtg taaataccac atttaggagg gcttatgatg atgccaatta atggagacct 97800
ttttgaaaca ggaaggaggt gaaacatatt cctttgcttc tacatcactg tgtgccaggc 97860
actgtttaca gcatctcgtt taaccagcag tcaccacctg acggatggct gatgtggggt 97920
ggggtcccag ggtgggattg cgtgatgggc ttggggtctc tggctgatgg gtgccagagc 97980
tgggactgga actcctggcg tgactgaggc agacacctgg gctacccagc ctcacccacg 98040
acgccctcac taagtgaccc acaggactca ccggaagcag ggcagcaagg tccccctaca 98100
gaggtcccca ctgcaaaccg atacccagct tagacagcag ttctgcagtc ggcgtctcac 98160
cccttcgggt ctcattgtga ctcactttga tagccacacg atttaagggt ggttcagtag 98220
tgatttgatg agtgctgtgg ctcagggtca ttcccctgcc caagcatttc aaattccaga 98280
agttcatgcc ctgcatggtg ggtgaaaagt ctcaggccaa ccatgagcac acagcagcca 98340
ggcgactgag gcagctgccc ggggtggcac gttgctcaaa cccatcattt ggagtcaaaa 98400
caaacagatg attagctggg gtggtcactt tcaatcaaga gttttcacat cgcctagaca 98460
tggcctcaga atcaggcctg gtgtggccag gggctgatct cacagtagac aggaagtgtg 98520
gcccgagggc catggctgcc ccctcagaag gccctgtgga gtggctggcc gagcctcagc 98580
agcctcctgt gaagcgagga agggtcttcc tgccggcctc tggagatcag tatgggaatg 98640
cacaagtagg aaacgctgga tgggaatccc tctgccctgt gataccaagg cagtgagttt 98700
gtagactatg gaattgctgt cggagggctc tgtaaccggc caaggtcaca caggtagcca 98760
ttggtagagc agggactgga atcccagacc cccaacttcc aggactgtgc acctttcttt 98820
atcccataca gccttacagt caagtgccag tgcaacacct gattcccagg ttccagcctt 98880
tgtcttttat aatgggaatc aaccttatct tgacgatcca gagatagtca tcaaggaaga 98940
ttaaattatc cccttagact cagagtgacc atatcatttt ccctccacac aaggacactt 99000
ttgagaatga aaaggaggag atgtctgtac cagacgctgg atgacaggca ccgacaggct 99060
gtctgccagg ggagcagcga ttcctgtatg ttgtagaaag tttttcaaaa gtcaccttgg 99120
aaagaggttt tgttccttaa ccttctgtta aataggaagc tccgtgaatg aaaacaactc 99180
ccttccctaa acattctagt aatgacccaa cactgccaag cctgccagct ctgcctcatg 99240
gtcgtgttga ctgtgtgaga ctatgtgagt gcctgctaca cagtacgctt tcagtaaaca 99300
tggtattgcc tcgataatcc cacaaaaatg tcctattcaa atcacctggc acccaggaaa 99360
tttccttctt ttttttccca ggtgaaatat acagttgaaa acacctgaca gcaattcccc 99420
tctcccatgt gtttgcagga tggtggtttt ggttcctcca tctttgatgt gtacaagtgt 99480
gatgttttcc ccccacagac aagtaaacca cattctcttc acattcccaa tgttttgtca 99540
atgtacctcc ttcaatagag gatcgataag gaaaaaaatc attgacaatc tcaattagat 99600
tcactatttc atccaaaagc atagcttaga actctagttt ttgttcaaca ctcttgccct 99660
atgagtgcac agaactttaa ttctgataca aacatccctg aatgtttagc tttgacagag 99720
attccaaggt gatttgataa gaagcagggc tgtgtttggg ctctgggagt ttttgatatg 99780
gtttcaagcc ccatccaaaa cccacagacc tctagaaagt aggtgcctgc cttcctgcag 99840
cagccctgga gcctgctggg ggctttgagc agctgctgcc aagccaggcc tcacccgaca 99900
ctctgatggg cacggccatg gtggcagggg cttggacgct gccaggtgac tctaacttgt 99960
ggccagggtg ggaagcactg ctccacagag gtgccaaaac caggttcctt cctgtgttct 100020
cacatttcac agcctcaatg taaaaagtaa gacatgggca ctctggaata ttacaaaaat 100080
atagaaaagc atgttatagt aaataaaagg ctcacagaat tttgtcattt aggaacaatg 100140
attattaata tattagtgtg tgtttttgct cattaacagt atatcctgag atatttccta 100200
taccatttaa tattttaaaa gatgtttaca ctggccacag tagctcatac ctataatccc 100260
aacactttag agggcaaggc aggaggatca cttgaggctt aaaaattagc caggtgtagt 100320
ggcacatgcc tgtagtccca gctactcagg aagctgaggc tggaggatca cttgagccca 100380
ggagttcaag gctgcagtga gctataattg caccattgca ctccagccta ggtgacacag 100440
tgagaccctg tttctaaaat aaataataaa taaattaaaa catttaaaaa tacatgatgt 100500
ttaattatta gaggactcaa ttttatatct atgtatacaa taatttttaa gtttcttaat 100560
attggacttt tagtaccttt ttaaaaatac tatttttaaa aaaatctgta tttctaactt 100620
tttataacaa ggaacctttg gctttgagat gactggggaa tccattcttt cctatagtat 100680
ccatgtccaa tggacttaaa gtattaatca atgtgtttat gttttgttat ttttctggca 100740
ttacaaaaaa ttctaaatat attgttaccg cctgtataaa tatcagcttt tgagagaagg 100800
acattgtgta gaaataatga aacactgcaa cttgtatttg tattattctt tttttttttt 100860
ttttttttga gatggagtct cgccctgtca cccaggctgg agtgcaatgg tgcgatctct 100920
gctcactgca agctccgcct cccaggttca caccattctc ctgcctcagc ctcctgagta 100980
gctgggacta caggtgcccg ccaccgcgcc gggctaattt tttgtatttt tagtagagac 101040
ggggtttcac catggtctcg atctcctgac ctcatgatct gcccgcctca gcctcccaat 101100
gcactgggat tacaggcatt atattattct ttaaattcac atgagaattt agtatggctt 101160
caaaaaatac cataagttaa aatatcacca agactctgtt cagacaaaag tatcagaaaa 101220
gtgagccagg cactcacata gtttatagtt tataaaagtg agacaggcat gatctcttaa 101280
cctcactata gtcctgtgaa taaggtttat ttacatttca ttttacctgc caggattatt 101340
gtaaaaacgc caagcacatt gcctacacaa actaaatatt cagtcaatgg ctgctatttt 101400
catgagttcg ttttaacata tatttattgt cctctactgg atttaagaag ttatatttat 101460
tatcatctaa gattttagct attccttctc ttaaaaatag attttataat caatggcagt 101520
aagggagagt aactcgcagt tctctgaatc tcaaggggtt cctggaagcc ttcctgaagg 101580
tatagtgaaa tttcagcttc acattcccat ccatgagctc cctgcaaata tcccggtctg 101640
ctctcaggac ccagtgactt acctatgcag aggctgtaga tagcacctgg agcttcctgt 101700
gtgccctcct caaactcagc caatgccgtc atacagtagc aggcaggtgt ctttgctggg 101760
tagttggact ggatgtccct gggattgcag aactggaatg gggagtgaca tcaggaaact 101820
ataatcatca ggacaacatg gtttgccata actttaagtt ttaagcgacc gcagattatg 101880
cggagagaga tgcatgccca cagccatgct tcccatgtaa ctggagaggg gtctgaagtt 101940
tgaaacaagt gttcctaggc acgggttaca gtgtttgtta tcatcatact tgatttagaa 102000
tggggcacaa catgtggatt catggtaact gttacaacct tactcatttt aatacctgaa 102060
aacatgcttt ccccatgctg ggaatcgaaa gattctccta ggaaaagaaa ggcttgacaa 102120
catcgattca aaaagggcat gcattttcct catttaaata actctaatgt gcaagtagat 102180
cccctgacct caagctcaga agagtccagg ccttcacacc ttctctgctt ctgctctggg 102240
gccagctatt gagattcctg tgcccacgca atgcgcacat cccacccctg gccgctgtcc 102300
acaagaaatc cagttgcacc aagcacccca ctttttgcac ctctcattta tgtactccta 102360
agagcctcac cacaactccc ttctaaaaac atgagttcct gactgggaat tcgatgctgc 102420
ccaggcagct ttgctcagag ggagcagcct tctagaaatg tttcaagtaa actttcaagt 102480
ataactaaat tcaaaaaaaa cacatacaca cacacacaca cacacaagtc aaaggtgtgt 102540
aatttggcca atatcacaaa ccaattagcc ctttgtaagt ggcacccaga tcaggacagc 102600
tgaccatacc agcaccctag aagcaccccg tgctgcctcc tgggacaggg ctaccaccat 102660
cctaaggcca gcacgatggg ccagctttgc ctgctgttga attttgctta catagaatcc 102720
tccagtaggt actcctttgg gtcaggttct ttcactcaac attatgtgtt gatatttttc 102780
catgctgtgc tgcaaaattg tatttcttgc attccataac tgggcagttc catcatagga 102840
gaataccaca ctgcgttcgt ccattctacc gccaatggac atatgggttc tttctctttt 102900
cttgcagtta caagtttatg aatattgtcc cacgtgtccc tggtgaactt ttgtttgcat 102960
ttctgttggg tacctcagag tggcgttgct gggtcagagg gtactggtcg ctttagtagc 103020
tttgaaagat attgccaaaa cattttccag cgcagttata gcaaattata caccaccagc 103080
agtagaaaac atctcctaat tgctcacagt aaacccccaa agattgccac atacatcttc 103140
catatcaatt acttaactat tcagcaaatt tgaagggaaa tatatttaat ctttttattc 103200
aaatagttta taaagtggaa tagagatgtg ggtaaaagtt gtcttgccac ctttttagat 103260
cggtaaaagt ttgttgaatg caggcaagaa aagatgagaa ataatggtac ccaatgaaag 103320
acatagcagt ctacaaggag gggcatttcc cggggtgggg gggacccaca ctctgtaact 103380
cccacattca attagcatgt tataggtaag ctgcagaaaa cgaggcagct tgtcaaagag 103440
gaacggctct tggccatggt tgctgcccta ggaggatatt tgatactagc agagctgggg 103500
caaccctgga ggaaaccacc tggaatgatg ggagaactcc tccagggaac atggcccttt 103560
aatagatctc tgttataaaa aataatccca aagcagccac cagggcatac tgctgcgatc 103620
aagtcctagg cggtattccc ttctgcgcca tagaccctgt gcagagtgcc ctcaacgaag 103680
gagcaaggaa gaccaagtct cccgagggtt tgcatatgtg tatgtgattc tgcagtcatg 103740
gtgaatgaca cagtcagggc tgcggaaaag cattggtaaa gtgtatattt gaggcttcag 103800
aagtttgaaa aggctagatt tcctaggcca aaacactgaa aatttgcaat tagaacttca 103860
gtgctgatgc tgggaagact ggagttagtt tgagacatgc acctgtgcag aactgggccc 103920
ccagaaaagg agaaggaagg gaatccagac cagagtaggg cctgacacca ctcagactcg 103980
gcgtgtctat aaattagaat tgcgttacaa ttacactttg acattttagt ggtttttaaa 104040
gtgcccagca caagttaatt tttcattaat gaatccttta ttcataaaat gcttagatgg 104100
agattaccct tttgagcatt ttgccagtgc ttctgaaatt aatggggacc tcctgttgga 104160
ggacacagtc tgttgcaata ggtgaccact gctctgaatc tatgtcacct ctccaggacc 104220
acgggcacaa ccatcacctg aggcatgttg gagatgcaga tggtcaggcc ctcctagaat 104280
ctcagaatct gcattttagc aaagtcctgg gtaattccta tgtccattgg agtttgagaa 104340
gcactggtaa tctcaaatac tttaaaagat tactagagta agataggctc agtaggtacc 104400
tgaaggcacc atcccaaaga ccagagtggt agaagcaggt ggaccagcct ctgaacacat 104460
ttctccccca ctccccggct gtgtggaagg ttgccacctt tggggtagtc attcaacaaa 104520
cacgtgtcaa ctgtccacta tgtgtcaggc caccactggg cactggctgt ggctagctgg 104580
atagacacca tttctgccct ccagaaatgt catgtccact ggcacatgac aagtcactaa 104640
gtcattcaga gccatgggtg acagctccag gggccgacaa aggagctgtg atctcacaga 104700
tccacagaga agtgtcccag ggcgggcggg aaccaggact gcacagggag gggtgaagtg 104760
acacataaga agtcagccca tcagcctgaa atgctccccc aaatcttccc attcagtgtt 104820
ttctcagtag caaactcgtg ggaaaattgg ttattttact taaaaaactc atactagaaa 104880
gctagtttaa ctttaaaaat aaattttaaa aacattttta ttaacaaatc ctacctttcc 104940
tccaaagtca aggagaaaag aatagaagtg aacaatggac caagtaagcc taaaactctg 105000
ctctttcccc tgctcatttt acagttcaag tgccattcaa tttatcctgg caagaagagg 105060
aaggcatcat caagacctta attttctaat acatctgatc tgagaagaat gtgaaagcta 105120
taaaattaat ttttgatcaa taactacagg ccttttgaga gagtgccctc ctaatgaatt 105180
gagtacctat ttctccatac acagtgtcta tcatgaccta caaacccttt tcccatgagg 105240
tgtaacagag agagattaca gccttggaac tggatgtcag actctcctgg tttaagacaa 105300
taagccatga catagagcct gaaaccaaca caatcttccg agtggttcca gaaacatata 105360
ggggataatg ttggctctga tgctgtacat ccccaacaac catcaactat ttggaaacta 105420
gaatttcagc ataattggag ttggtgttac cctagcaaat gctgtgggaa gagagtctca 105480
ctgtgtatct tctcctgttt aaagcctgaa tttgttcaga atgtaatatc tctgtttagc 105540
cactctactg aaactgatct aggaaatgtt caaaaaaagg tatcccaagg atccctttgt 105600
agctacatct gtgggattcc cctcgctctg gcgtggcctg gcccctctgc atttgacaat 105660
acggtcctat gcttttgtct tcctgggctg cgtgaaccca ccctgccctg gttcacctct 105720
cctcttgacc catccttatc agtgtcttga aaggtccttc tattggagga cacattctgt 105780
tgcagcaggt gaccactgcc ccaaatctgt ttcacctccc cagggccatg ggcacaacca 105840
tccctggagt gtgttagaga tgcagttggc caggtcctcc aaaatctcag aatctgcatt 105900
tttgcaaagt cctgggtaac tcctatgtcc atgagagttt gagaagtact ggtctcatga 105960
gttcctgaca tacaaatagt gctgaggcca gtatgctgac tgggtagcca gatacaagtg 106020
aaaaccttcc tgttttttgc aaacctggat ggacccgagg ccgctgacgt gggccaggac 106080
aagctactct ttttcagtgt ttctgttgca tcgctgtgtc tctctgtgat caggtgctgc 106140
cctccctggc aggaggactg cagacaggat gaccaagagc actctacaca gcctgctctc 106200
cagtgttggg ggacgccacc caccctcgtg gttcctgttc atctgcctac acgtggaggg 106260
cccaagaggg ctaatatgtg actatctcca cttcctggta ccctgtgtga ataacttcac 106320
ttactaaagg gatgttgagc aactttatta ataatgaaga aagcactttg gtttgacaaa 106380
taatcactcc attttttcat ttgaaagtta actcttgtta gtagagaaag caatgtatta 106440
caaccacaag gacgtttaca tggaaatgaa ccatctgcaa agcatccccc attttccttt 106500
taaatcagcc aatgggtggt ggtgggagaa atattcacca gagtatttaa catctatccc 106560
ccttcctaga ctgtcagctc catccgggcg gagactgttg gtatctccac agcacacaca 106620
gggcctggca cacatccggg gctcagtgag cacttgctga atggtgaaca gattagctct 106680
cctgggaacg ttgttgacac atctcataac actggtttgg agtggagggc attcatcggg 106740
ctgcatattc ctatttttaa ttgtattctc cactggttac agcacctaca gttataaaga 106800
cattgttaac attgcttata ggaagacatt tgatggaaat gagtccaaag gcattacggt 106860
tagaaactgg ccaggtgtca tttttgagag attagataac tgttttccgg tagagtgaat 106920
tgcctgtttg ttgcaagttg ggactttgct gggctggttt acagggccaa ggggaaagag 106980
ataagtggat cttctagtga gaggtcatct gttttgaaag cctggaagat tccatgaact 107040
aaatccaagt cttacaacac agggaagtgt gtcatactgt gcagggatga agtctccaat 107100
ttagcatgaa aacaagagct cctcacactg tcctcttcag aaagcccata caatccaaac 107160
ttctgaatgc ttagctgctt acaaccatac atagattgag ggataaaact ctgatatgga 107220
agagaaggta aacatttttt ggcagacatt cccaggaaaa ggcggctctc ttctctcatt 107280
gctgctgctc tttcagaatc catttcaaca gaggaggagt caatgggagc cccgtgcctc 107340
tggcagatat catatggcgt ttcagtggca ttgtgtgtta cccttcttag gtaacagctc 107400
agccattaga agaatgtcct acacaccttc tcattttctg tgatgagagg aatgtgaggt 107460
actgcccttc gagagctgtc atttgtccta gtagccagca gcgtgactgt gctgtcttct 107520
gctctgtctc cctgtcagcc ttctgcccag ccaccaccac tatagttttg ttctctccat 107580
tggaactcct ggttcagaga attaccataa aaaacagacc cctagacata caacactcta 107640
tcacataatg gtgactttgt cttctatttt ggattactga gctttcttgg gtaacttcca 107700
ctaaatcgaa gttaatatta gaagaacttc ctcttactag aatcgaaaag catttaagtg 107760
atgcagtcaa gtttgtacca taagtaattc agtcatttaa caaatatata tggcctctgt 107820
gcgacagtga ccttgactgg gaatgaagct gtcccatgtg gggcctgttc ttcaaaggca 107880
gttccctgct gcccagttca gtccagtgga tctgggcatc tctctttaat ccgcattagg 107940
ggctctttac tgattcttca ctatccaaaa agacttggag gggagacctg agcccacttc 108000
tggaaggaaa tgataacaat ttatttagat aatctttgtg caacaagtca attcactgaa 108060
gagatctgct ctctaggagc ctctgtgacc ccaccataac tgggaaggct ctacctctcc 108120
agtcttcggg ccacatttct ctctggcctg ctgtcttccc agcactctca gccttgctca 108180
tggagcactc tagtcctccg tcgaccttgg cctttggtaa cgtgattttt cacctggcag 108240
ctcccatctg gtctcactcc ctctttttgt ccagtctgca tgacacagcc tcacatcgtt 108300
agtgttccct cactcccctc ttactgccca acctgcaaag tccatgcctg ggccagtgca 108360
gcatgtgtcc tcaatgggct gctggtggca gtggggggaa ccgcacagcc acgctgtgtg 108420
ctgctgaaga aatgcacagc ctcctaccct cgccctcaag aggcagccat ggctgcgcat 108480
ttctgccctt ctgagctccg ctcacttttg gcagcagccg ttccaacctg catgggatct 108540
tcactctctc acagatgtgc tgactcctcc tgctgcctcc cctctctgtg ccttctcact 108600
ctctgttccc tttgcccttt ctcccctttt ctcctctgcc tacctccaag ccatccatca 108660
caggacagct caagcatcag atcctctggg acactttcct tagttgttca gtctgatgag 108720
gtgtccctca tcctctctta gctgaaaatc agcagctgcc tcaacttctt ttccagcatg 108780
tctcatgagt attgccacaa cagcatctgt cacaatgtgg ggtagtggct gacttgcttt 108840
tctgccattc aactgagttc cctcagtgct ggggccagcg tgcagtgtct tgtattcagt 108900
atatagctga ttaattgatg aattgattaa ttaatggttc acactagcac agtgcaacct 108960
tcaatgcaaa gatctcatca aaataattca catggtggga tattttagaa ggatgaccag 109020
gctagtttgt agtaagaaaa aatcaacaag actaggtcag gaattctttt tttgtctaca 109080
ggcttgctat agaagatatt gaaaatcatc tacctaatta cctttatttt atcaggttgt 109140
gtattaaata tcacgtctgg gggaagaaaa tgtgatatgt gattacagac ctttcctggt 109200
acaacatagt acgtttcaga ttaactcaag gtattgtggt gatattgcgg tcaaagccag 109260
gtgattaaag agtcattctt tgaaacaaat atctgtgcaa tcaattaaga aattaatttg 109320
caaattttat ttgcttagag taattgatat atcattcctt ttacaaacaa atataaagaa 109380
aacttaacta aaaatactgc atatctcttt cagattatat atcccagaaa ggatatattt 109440
ttctcctttc tggtcttcct ttttggtgta gcatctgtag gaaatgcatt tcttcatagc 109500
taagtgtacc tccttgtgaa atatcttcag agtctactgg tgcacataag caattgctgg 109560
cagcagcttg agggtctcca tctcacattt atcatatgcc ttattgcatg aggctttgca 109620
agaggaggtc tagagctaca atatctcatg gatatgaatg tcaattcaaa tcccagtggc 109680
agtttatgag ggggaaagcc tagaagagaa gaaacctaga ggaatcaagc aggaggggag 109740
agtaataaaa gactagagca gcaggttttt cttaactcaa actagaatta aatctctgtg 109800
tgtgtgtgca tgtgaatgtg cccgtatgtg catgcatgca cgtgtgtaaa tggatgtgtg 109860
tgtgtgtgca tgtgtgtgca agtaagtgtg tatacgtgtg tgggcatgta ttgtgtacat 109920
gtatgtgtgt tttatgcatc tgtttgcaag tatgtgtgta tgcacataaa agtgtgaatg 109980
tacatgtgtg cttggtgtat gtgtgtgtat taatgtatgc gtgtagttct agagtctagt 110040
tagagaaagt gcataaagaa atagggaaat taacaagaaa gctatagctt aaattatagg 110100
aaaaactttt ctccctatca gtcatggttt taaaatgttc agacttgata tgtttcccag 110160
tgctattgtc agaaaatgtc cctatgacat tccatactac ttcaatcaaa tctaaaacct 110220
ttgttccaac atgttttatt gatatgagta tatttcaaat ttctaccagg tttttggaga 110280
ggtattttgg ccataaaatt gactaaatta ttcaaaataa aaaatgaata agcctgggcc 110340
aaggcttgga gacttgctta actcagttct taaattttca gattttcaaa attacaaatt 110400
taagctctaa aatcatggtg ctgtgtatga tattctttga ttgcaactta tggttgaaaa 110460
actatagagg gctttatgct aagagttgtg gatcttagga ttttcatgaa atctgcatta 110520
tcatcatctg caagtttaga tggggcataa ctgatccaaa ggatggatcc ctcgggggca 110580
attcaactgg ctgattccag ccaagatgac aacagtcagg atccgttccc ttctgatcat 110640
ccattgggtg ccctgatttc ctctacagcc ctagctgaaa gaccagacac tatctcaggc 110700
tggctgcccc acatgccttg ctccacacca aattcacagt ctataaacct gagcctccag 110760
tgctcctact accatactca ctcgaacatt cccgattctg acctggagat gtcaacagct 110820
acttgatgcc actctcttct atctttctgt agctaagcca tccccaagtt tgtcgattca 110880
ccctctttaa cccctgtcgg ggtgtccatt gtgccccttc accctgccat ctccctggtg 110940
cactgttttg caaagttcag catacatgag cgtcacctgg gaaccttaat aaagtgcaga 111000
tgttgattca gcaaatctgg gatgccctcg ggctgcattt ccagcaggct cctggggatg 111060
tccccgctgc tgtgctgcag atgacactct cagtggtggg actccaggct ctgctgtcgc 111120
ctcctagggg tttctccaca ctccctggag gcctaatggg cccttctcca catggcagta 111180
agatctgttt ttgtgtttgt gtttcaagtt gggagaagga gattatttaa tactaaaatg 111240
tgcaacatgg gattgagaaa actaattatt agtcataagt tgagtatgca acattgaaac 111300
cacatgcttt aaaaaattat aagaaaaaat catagtattt gaaagttaca agctattatg 111360
gctaactcca tttatctcag ttagagaaga agagtcacct gtcaccaggg cactgccaga 111420
agccaggctc atttccaaca gcactgggtg ctccagcttt ggggtgccag ctcctcccat 111480
aaagcaaaca catacctagg gatgatattt ctttgcaagg gctctgccct acagcttgta 111540
catctcaaga agttatgtaa ttaaactgtc tgttttgaga aaattgtaga ttcacacata 111600
ctagctgtaa gaaatgatgc ggataaatcc agcgtaccag ctttccccac ggagacgtct 111660
tgcagcgtca cagccaggat gaggcattga cccaggcgaa gtccagagca cctgtgcgct 111720
acagggcccc ttgcactgtg ctgtcacaga cacgcccact tccagatgcc atctaggacc 111780
ccctccaaaa agcagaggca ttcttaaaaa cacacatctg cacatgttcc tcttcatttg 111840
aatctgtcag tggcttctca gtgcctttca aatgaaatct aaagtcctta caagccttgc 111900
agcaggaacc tctccatccc acttcccctc acactctcag cttcatctct gctaggctct 111960
gttcagccag gcagcctttc acagtccctc tcctcctgcc ctgccaggaa ggtcccctgc 112020
ccccaactct tccccacatg tggcggggcc ccgcttgtcc ttagaagccc agctgaactg 112080
cttcctgaag gaacccctcc agaacctctc agaccaggtc aggtttctgc actcttagat 112140
catccccatg gcataatcac agttgtgatg ttgtgatgat tcagtgaatg tctgtctccc 112200
cactggatgg taagcttcct gagggcagga acagcattgg ttccagtcaa tgctatgtcc 112260
caggactgtt cgtttttgca catactaatc ctaaaaggac gatgacaaca gcaaccactt 112320
acatgaccta gatgctcttc tgggtgttgt gcaaatatta acaatttaat ccttgcaaca 112380
atccacgagg gaggcattct tctactccca cttaacagac aaggacagtg aagctagtaa 112440
agagaagtca tttgcccaag gggaccccac tactgttggc agagctgggt gcaaacgcag 112500
gcttgtgaag ccaggaccca tgcattcaaa gaccatgcca ggtgccccca ctgcacacct 112560
catccccaca taccagtgag ggggagagaa atgctcctgc actgcctctg attaactgct 112620
ttcctagaag tcacacatat aaaagggatt taattctagt gggattgaat ctcaatagtt 112680
tccttattag gttgatttct gttaatagtt taagtactgg atatacatga attagaaaat 112740
ctagattatt agcaaatgca aactataaag tattttataa atgttatctt gtttgtcagg 112800
ggatgagtga gatattcatt atacaaaaag tagtgtggat tttgaggtag aaggtttact 112860
aaggatcata ccgtagtatg aaatagccac aaacattcag tgaaaccaaa cacccccgct 112920
taacctcaaa ctaacactaa ataataagga atagacttgg gggcagtgca agtgtatttc 112980
taatggtgaa aaccattccc cagtgaaaac taatgtacca tctagttaat aagagctcct 113040
ctgacccacg cacatcaata cttacatccc aatggtgatg tgacattttg ggttttgtat 113100
ttcttttgca aattgagcta gcatttttga tgagtggcag ggctctgcta cccaaccttt 113160
ggacagtttc caagcataaa atcacaattc cagataattc tgtcacaaag atctgggtct 113220
cattaggaag gagaggaagc tgggagatga tccagtccaa cctcccccaa accaaacatc 113280
acggccttct cagttgtttc accaaccatc taaatgtttt agtaattcta aaaattgatg 113340
cgctttttcc acgaaaggaa gtgttaccac attttccaag tgggaggcat ctatatcctt 113400
actccttcat cctctccttc ccaccccctc accccccacc acccacacaa catctgcaat 113460
tcttaaacta aagcacaaat tgttacaaaa gttaattgca ctttcaaagg aatgcttgta 113520
tagaaacttt ctcggcttca aggaaaaata atacgctttg aatggctgtt caacagcata 113580
gaaattagct gagtagaagg cactcatata gccattagga ccaatccttt ctgccgccaa 113640
cacccccctt ataaagactt gacagtgggc cagaataaac aacttcagga tgaattcagt 113700
tgagacacaa agtacacact tccagttttt cccttctctg gttactggcc tcaataacca 113760
ggcagtcaac ttaaaaagaa aaacaaaagc ttgcttcaga ttacagattg cagacttctt 113820
ataatatgtc catttcacca ggccccgctc tcagccccgg gaaaggccac tggaaaccac 113880
ctcacatggt agggccttgc gggagccagt aataacctta tctccgtcaa catgttctgt 113940
cagattgaat ggggcagcca gagaagccag agttggcaca ggaaccaaaa caaaggcttc 114000
ccatcctcct ggagtgagcg gttgagcctg gattggtgct tagacctata atgggtgcaa 114060
gcagcgttca ttcatagtgg ctttctagac ccagggactt ggccccagcc ctgctgctcc 114120
actcctcttc ttgcttcatt accacgagtc tcctagacca ccgaacgatg cctgcatttg 114180
aaagacactt ctgctgatca aagcagctga tgtgtccctt tgcggttcat ttctaattgt 114240
ccccaaggag gagaaattca aatagtttat tactgagagt taaagaaatc cactgaaata 114300
ttctttggtc taaaattact gtcatggcgg agcagcttca ccttagtcat tgcccttaaa 114360
tatgaaagct atttaagaaa gtttgccctt aaatatgaaa gctattttaa aaagtttaat 114420
gaaagaagag aatcacaaaa cattttcaaa aagcaaaaga aaacctaaga gaaaagttga 114480
aagtaggaat tttttaaaga atatacgacg tgtgttctgt gactcacccc tgcaagttat 114540
ttgtgtgtat tcccttgcat agtaattaat aatgaagcaa agcatggcaa tgatatcttt 114600
tcttgtctag tattctagaa gactccatgt ttttggaaaa tatcactcta gttagatctc 114660
aaatatattc aatcagaaaa tgggttttct acaagattct atatctgtag tcaatagcaa 114720
atataattct attaagctag taggatgtga taggaaacta aaacctaggg gagaccaaag 114780
caaggaaaaa tacttcctca tccaaacttg agagcaattt accgtcaggc ctactattaa 114840
tagatggaat acagattcca ttttcattac tcaactgcca tattcattat tacactgtac 114900
agaaaaggga atcacatctg ttgaaaactt atatatgatg ttcatgcatg cattccagta 114960
attcaacaat ttttatttat ctttttattg cttgctaatt tttcaaaata ataagctaaa 115020
gaaaacaaaa tgtttgtgct gttctcagat gacatgttat ctctttaaag gacaaaatgt 115080
gctgtgaaat aatagaatgc tttcagcact caagtgtgag tgagtgctca tacatgagag 115140
aaagccgtgg ggactacaga agccaagaag cagatctagc tggggaggcc tttgcagagg 115200
atgtagttgt gtggagaggc cacacacgtg gaattcccag gagggctgtg gaggcgggga 115260
atctgcagga aagcactggg gtgagaaacg tgatgagaaa caattattgt cttaaaatat 115320
ctgcagggct gtaaggtaga gaagcaatac gttgcatctg tgttaagtca aacaaaatta 115380
tcaagggact ggtttcagct taacataagg aacaattatg tgatagggtt gtcaataaca 115440
agagtagact gcttcttcac acactcctag tcactcagaa tggtccagga ggagtggaca 115500
accatttggt agagtatggg aaggcagggg ccctgggtgg gagtggtgag ggtagggagt 115560
gagtatccca atctagaagt aaattgtgcc cagcacggag ctgcaacact gccctgcaca 115620
caaacacaca caaataacaa tccccagccc ctgcatttcc ctctccggtt tcaggacctt 115680
gtatcttact tcaattcctt tatttagctg atgatgaaat aggaagagct tagcactaag 115740
aaaatccttt tggagtttgg ccttggggga aaatgaatca ctccaaccag gtctgtcttc 115800
tagaaagtat aggatgaaag ggctcctcat cacatacttc ctgacctcct gctaggcctt 115860
tccctaaaac aggggctggc aaagcacaac ctgtgggtca cgcctagcct gccacctgtt 115920
tttgcaaata aagttttatt ggagcatgac tatatgtatt tgcttacagt ctgtggctgc 115980
gttcacacta tcccagcaga gttgaataat tgggacaggg accatatgat gggtgaagct 116040
gaaaacattt actctctggc tgtattcaga ggaggtttac tgagcccttc tctgagacat 116100
ggcaagcgct gcttcaggct catgcttcac tagattcagg cctggggcag taaagagcca 116160
gctcaggata gcactcccga ctcactcatt ttttcaggca ggggagccat ctaatgtcaa 116220
gtgcctacgt gcaggaactg gtctgttaat tagcagctct cctcatggaa gggataatat 116280
attctagaaa caggagtgcg gccctattgc aagaatgtcc tgagccaaaa ttaagattct 116340
tctatggcag aaacttggct ggggcttctc ctgagttaac ttggtagttg ttagtgattt 116400
ttgagtcagt ttttccttgt caacgacccc aggaatgagt ttgggattac agggtagcca 116460
gggaaaggga aagcttcacg cccgcccccg ggacaaggtc tgtcttcaca ctgctacatc 116520
ccttcaccca ctttaaaatg aaacttaaaa ggaggatttc agttgagtag gaagtgagaa 116580
gagggctcat tttaaaacaa gcgttaaatg aaaacccaca cacactcaga gcacacaaat 116640
ccaaccacgc ttacaaaacc atcacagagg gtcaggcgag gcccttttct aaatgaaaaa 116700
gaacaggggt ggagactgtt ctgagagcat gctgggttcc ctgaagggaa ttctcagctg 116760
tatgtgcccc gcacaggatc cctgctagac acaaggccag ctgccttcct ttcaagccgc 116820
agacgcatcc ctgtgtccag gcgggctggt cagctgcggt cagcaccagc ttccccgctc 116880
catggtgagg tcatcacaac atgtgagcag gagggcaggc cggcaacctc tgagtgctta 116940
gagaaaggga cgggattcct cctgtgcaac ccctctagtc tcactcagac tcaagtctga 117000
ctaaggggcc aggtgctttg accagggact ctcccctctc acttccctcc caggagtcac 117060
aggtacatga gtccttgttt tacaaatgaa gaaaacagac ccaacatgat taagatgttg 117120
ccttcatagg ggtggcacca ggattccaaa ccatggactc cactgagccc agtgcccact 117180
gacatgtgcc agtaacagtg cagctgcctg tggttctgtc gactaaactg ccggcagagg 117240
ctggctttcc accttctttt tttttttttc actcttcaaa cactttatga catgaacata 117300
aactactggc tgcatcgttc tgctgacaac atgacatgtt tctataactt gaaaaaagca 117360
agcagtggac tgctcattgg taaaattgag tcagtaatct tttaggaagg ttatttttct 117420
tccttttact gcttctcatc tgttccccgc agtaaagagg acaagatgac gacgactcag 117480
ggaacacctc cagcctgaag cagcaccatg cgagcttaga ccttagggtc ggcttagaaa 117540
ccacaggcgg ggcggcttgg gcccctcgga cactccctct cgaagctgct tctccccaag 117600
ctaccccaaa ggcactgagc gccctctgcc ccccagcaat tcaattcact ggctgtcctg 117660
ctcctgtcag tactgagagt tgcatgtttg accctcgggg gaaaagtcca gaggccctgg 117720
ggtgtccagc atgctctgag gtccctgctg ctgacccctt gcgctgtcag cattcagaga 117780
cattcacaca gcacagcctc ccaggctaac agctgtcatg gaacagtgga gcagctagac 117840
gtggccattc tgtggcccag tgctgcagag gtcaaaggga caagcgcagg gagcatcttt 117900
gctttcagaa aaaaaaaaaa aaaaaagaag cacactggtg cactgacctg ctcctggtgt 117960
ctttgtgatt gctcttttct ttcgattttt ggttgtcttt ttttttttga aagaggggct 118020
tttatgcttt tttcctaatg ttcatgggta aaccaatgta aatgtgtgta tgtttataga 118080
gatggcttta aatcgcaatt ctgcagtaga gattgatttt ttaaaaaaca tgggtaaaaa 118140
ttgaagaaaa attttaaaag aacatttaaa ccatcttggg ctaggggtgg atatgcacca 118200
ccccacggaa gccaaacaaa atctctctgc agataaacat ttgcaaaaag aatttccaat 118260
cccaattttt gagtcagaga tcttttattt ccttgcaaat tacatatctg tttcaggatt 118320
tttgactata agaagaatga atgaagatgt gtttcttaca gataactatg aacaaaccag 118380
gaaggataat aacttgtatc ccccaattcg aatccagagg atgggaaggc ataaaaaaaa 118440
gaaatggaag aaactttatt tttagtggta aatggtggga ctatgtattt tacgtatggt 118500
gaagtcacca agcccaacac ttggcacttg taggcaaggt agtcttctaa tctgaatgtg 118560
aagtattatg ttttcatttg cttggtaatg aggaatattg gtgctttcgt cccagttctc 118620
gagctgactg acttctcttt ctgacgtgtg ttcctttagc acacctctac actgcatggc 118680
tctgagatgt cctgtgactg tttcatgtgt aaagttgcct ccccaaagga ctcacatatt 118740
ccttcagggc agtgagtact tctgattcat ccttagcagc taccttcgcg ctactttact 118800
agatatgttg tagttgaatt aatgaacaaa agaacaagca actttggtgc ctggtgtgca 118860
tctcagagca gggtggagtg agcctggcca aagggtcatc atgcaacctc tgtggctgac 118920
tccatctggc cacggagctt ctcagccatg cttggtattc acatgacttc tagggcgaca 118980
gctcaaccag caaataaaca gcttcatatg ggaaatatta ctcagccttt gtcatcaagg 119040
agtgagtcac gggcctgaac tgaatagaag atagaggaga aaaggtgtgt ggactgggtg 119100
agacagcgcc cagcgaggtg aactcccggc agccctgcct gtctttacct gcacatcacc 119160
ttgctagggt gccttcggtt gtgagggcct gtctaggaag agaagagttg caccctggca 119220
ggcagcactg agctgtctca tgcaaagctg aggaagaaag agtgagctgc ccagtgagcc 119280
tgctggggtg gtggaggctg ggctgggctg tgcagtctgc agcccccagc agcccttggc 119340
acctttctac tgcctggtgc tcaccagctc tccagtaaca aagagggacg tgaagtcaga 119400
ggggaaggga ggtagcacag ggcagtcttg actttgaaca aagagctggc ttcctgaagt 119460
cagctggccg ggttttgaag ccgattttcc agcagtgatc tttgatgcca accccattta 119520
ggaattctgt atctccccct accttctacc agatgtctct gagctcacct ttggtgataa 119580
tcatgcaatc tccgtcatcc ccacgtccac actgccccat tctgtcccac cccgggttct 119640
gtggtgctgt cggctcccca gcgagccagg aagggagagg ccagctctgc tggggctcct 119700
gccgccctgg ctctgcactg cccttctctg gcaggtctga ggcgccactg gaggagccac 119760
acggccctga agcagcaagg cagatgccct ggacacagtg gaggcacaga gtgcaagcac 119820
cggcctggcc cacagacttt tggaggggaa gtggtattat tcagttcaaa agtatgcctg 119880
tgtgtaaaga gagagcccct gaacatgagt aagcaaaagt ctcagcgcag agattagaca 119940
agtagaatgc tggcccgaga ggaggcgttt actcaccctc tgtctaggaa ggaaagccag 120000
gcccagcacg ctcactgcta tctatcctct cacacagagg gattttgaat cgaagccagc 120060
atcctgtcct ttctccaatg tcccctgctc aggagtcagg actcagcaag gcccacccca 120120
gccacacaca gatacagttc caggactcag aactcagcga ggcccacccc agccacatgc 120180
aggtccagtt ccaggattca ggacacagtg aggcccaccc gagccacatc caggtccagt 120240
tccaggactc aggattcagt gaggcccacc ccagccacac acaggtccag ttccaggact 120300
caggactcag cgaggcccac cccagccaca tgcaggtcca gttccaggat tcaggacaca 120360
gtgaggccca ccccagccat atccaggttc agttccaggt aaatcatctg ccttcctccg 120420
tccaaaagcc ttgtttcctg tgtgtccttg tgtttaaaat ggaaacgtta tgagaaactg 120480
cctgccaggg caaagggtgc tgcccggcac acagtaggga ctcaaaatga aactattgta 120540
ttgaatacat aacagatcaa cgggtattgc tttctgaaat cttttttagc ccaattttgt 120600
ttcttatagt ccaataacag gtcaaattca tttctgattt actagccatt cagttgccca 120660
taaaaaatgg aaagtgattt aagattatta gtttaaaaac caatgaaggt aaaacagtta 120720
tcattgaagg cacataggca gaaatagatt gcaatagttg ctgccatgtg aagcctcagt 120780
gtcatgctcc atatttagag agatctatga tttctgaggc cctttcatgt ccatgatctc 120840
agtactgctc acaactgccc tgtgaaattc gccgagctgg ccccatgtca atcagagtac 120900
actgagcact gagacccagc atgttgagat aactggctag agatcatccc ataatggtac 120960
catcacaatc ttcacactgt agaagtttga tgatgtcact ggaagcatat tccacagtcc 121020
cttgtgaact ggccttcctg tgatcagaag catcagtgaa ctcccaagag ggtgggaact 121080
cccaagaggt attctcactc tacttagtgt atattttaca aatcacaagc ttggctttgg 121140
attcttttaa tggctagaag gagaatcatg gggttggaag tccaccagtt tgggtattct 121200
gttccctaac tcaaaataaa gagatgttat tttcaagtct tctgcttgtt aacttaatta 121260
gagatacatg agtttgcagc tgtgctgggc atgccgcagc ttggcatgtt tagtccagaa 121320
ggcatattat aatgtacatg gaagattgtc agaaattcaa aaggactttt tgagtatcac 121380
atgtgtattt tcaagttcca atatagattc acattcagtt tgacaggtat ctttggatgc 121440
ctatcagtta agaactattt attagttgtg gaataaaata gggtaaaata aggaacaact 121500
gaggaaaaaa cataaaattt gctttgtgaa taaaagttgt cttcaaaatt atgacttttt 121560
ccatcccaca aaagttttga ttaaacccac aatgaaaatt taaataagtg tatttacttt 121620
ggtttaacca cttatttcat tatgactcac aactataggt tttctagttt ccattattac 121680
aaactattgt gtggtttaaa tcaatttcat agactagtct agttctatag tcacaattta 121740
taaaattttt ttatgtggta aattgagtgt cttcatagat gtacatgatt atttctcaat 121800
ttttaaggaa tgtatttttt aagatagcct tctttagcct tctttaacac tgatttttgt 121860
aaatttttta cagatttttt taaatttttg gtaatttttt agcataaagt aatacatggt 121920
cactatggaa aacataaaaa cacaaaaact atgaagagta aataagaaaa acacccagaa 121980
atttaccatt cagaaaaggt cattgttaac aacacggtgt atcttcctcc tgtcatgctt 122040
ccgtgcattt gagcacattt gagatgtgta tacatgttca ctttgagatt ttagtatagc 122100
aaaagaaatg accggtcctg attcaatgaa acctctggca aactcgctat attttcctta 122160
catattttta agttcatcct ataaatgaac tatccattca tcttatttga gattttctta 122220
aatctttcag caagaaagcg ggaaaaaaat cctcctctgg cctttaaagc ctaattaaat 122280
atatgactaa gctagaaata ttttataatg accaaccaga aagtggcaag gactgtcact 122340
cttcccatac agcccacctc ctcctctatc tccctcaggc acacggaaac gagaaaggca 122400
gagaaaccca ggacaagtca tccaagactt tggtcacatg gccatccatt gctttcacaa 122460
caaaaatata aatccaacat gtgtgtgtgc atttcatacc agtaggtcca ataagctatc 122520
tatatataca catatgtgta cacacacaca cacacatcct tacagacact ccccagctta 122580
ctacagtttg acttaagatt ttttgacttt acgatggtgt gaaagcaatg cacattcaat 122640
ggaaaccata cttctaatgt tgaatttttt atcttttctt gggttagttg atgtctgata 122700
tgttactttc ttgcgatgcc aggcaatggc tgggagccag agctcccagt cagccatgca 122760
atcaagaggc taaacagctg atactataca gtggactgtg tcaccagcat tttggggata 122820
ttgtgttttg tgtttttgaa tcctatcatg tctacaaaat gccattttcg actgctattt 122880
tcaatttagg gtgggtttat caggacataa ccctatggaa agttgaggac catctgtata 122940
tctggtaggg aaagatggat aacaaattca taggcaaata ataatttcat gattattatt 123000
aagttattcc tacttaataa taagtagtga tcactgccag ggagcagaga atgcaggata 123060
atgtgacaga tgtaatggtg ggtacttaag ctaatgtagt tgcagaacag gcttttctag 123120
agggtaggcc tttaagcgta cctcgaagat gcaaaggaag caaagatgcg aagatctggg 123180
ctggggatgg aagcagagac aacttggagg ccaaggggag agactgacaa cagcccagct 123240
catacctcag cagcctttaa tgcatagcta agaaaacaac aaattaaaac aattatagtt 123300
tacttagacg attctaagtg tctaagtgga tttgggcaaa tctggagaaa cttgttctaa 123360
tactgtgtct taataagtaa tatagatttg cccaggcttg tgggcagagt ggtatacacc 123420
ccataatagc agaggaaggc cacagggcct accctacaaa accagaggca tttaaaaact 123480
taaaggaggc agattgcttt tattttcagt taaaataaag tgaggagttt ctcaagaaaa 123540
ataataacga gaccaccggc ccgccctaga tgtccaacaa gaatgcacag ataacttcgt 123600
atatccactt tcctgaacct gcccctgaca gccaagtgga gcacaacaac agagatgaac 123660
ctcaaaacta ctgtgctgtg acataaggct tgctcaagag gacagtgtgg tgtgagtcca 123720
tctatgttct aaagcaagca aagctattct gtagtgaaaa tggatcagga cagcagttgc 123780
ctctggtgta tgggggcagg gatcgactgg gaggggcatg agggatgaca gttagggttt 123840
cgatcatgac aggaattcag attactccag catgtgcatt tgttaaagct catcaaatgc 123900
tacacttaag attaatcctc tcacagtttg tggatgttac cttaaaaaca acaatgatga 123960
ctgcaaacta atattgaact ctggttagtg atataccaat gtgaagtata gtgatatctc 124020
tactttactt taaaatgcat ccaaaggcag actagaggac catatctgac agacagaaaa 124080
atagatatgt gataaggtga atgtagtaaa atgctaacat aaggatgttt gcggtacaat 124140
tctttcagct tttctataca tttataaatc ataataaaat tttaggacaa aaagttagtg 124200
ctttgaagtc ctaagtcata gggcctgctg ctcttgatgc agtagaattt gtcttcagat 124260
ttgcaaaggg taaggcaaac cactagcatt ttgtatggaa cttgatgcaa atacttttaa 124320
ttgtctggtt ttcaaatgta tagacttaaa gtaatatcaa ctctttcttt gaatcaacta 124380
ctgaaatacc tagtcttaaa taaatatttt tatgtaatcc ttaaagtact atgtattcat 124440
ttttctttct tctttctttt ctggtttgat aaatattcta taaagtaact gtgtttaatg 124500
gccaacattt gagtaagtcc atatgcagat ccaaacatct cagtttagac aataacttaa 124560
gacaatatag agtggctgac atcccctaac gtgggtccag atgcatgtta tgttatgttt 124620
ctgttgcatt ctcaatagtt aactttaata aaagaaagtc aaaagcttat atattttttc 124680
aatcttcaaa acatttctgg gaggttgtct tagttaattt tatgttgcta tacccatatc 124740
acagactggg taatttataa agaaaataaa tgtatttggc tcatggttct ggtggctggg 124800
aagtccaaga gcatggcatt ggcatctgct tggcagctgg tgagggcctt catgctgtgt 124860
caatctatgg tggaaggtca agagagcatg catgtgaggt ggtggggaag agaaaaagcg 124920
ggtttaactc atccttttat cagggactca ctcccgtgat agctaaccca ttcttacatg 124980
aatggcatta atccattcct tagggcacag ctctcatgac ctaattataa tacctcttaa 125040
agtttccacc tctcaacact gttgcattgg tgattaagtt tccaataaac gcactttgga 125100
aaacacattc aaaccacagc agagatcaac gttattgtca ccattttcat atttgaggaa 125160
agcatggcac agagagcttg gagaagtact tcaaggtcac ccaatgagga agtggctaaa 125220
caaaaacctt atcttaaatt aattaaaaac ctcttgctct ttgcagtttt gtcttaaatc 125280
tacctaattt gtgactgtaa tttttaagta atttactcat ataagtggtc tcacattaaa 125340
ttttctcatt gctttatatt tctaacatga gatatttggt ataaggatgg aaccaagatc 125400
ataccttgtt ttaattagaa aacctagacc aagtcattgt gatcctcatc ctagatttca 125460
gttaaatgct gctgtctcct tttgggtatg tgacagggga aagcctcaga agaaacaacc 125520
ttatgtgttt tcttttgata ctttagtaat taacccagga tagtattcaa gattgacatg 125580
ccttatattg aatcaaatag catatcaact gccttcttat tctcaagtat agacatgttg 125640
ggtaattggg catttaagtt tctttgcaat tttttccatt attaacaaaa ttaatgagca 125700
acattctgca taaggtctgt ttcctcagaa tacgtttccc aaagtggaat catcatgacg 125760
tagaatttaa gcatacttac ttgtttaaac aaattgtcca gttgcttccc aaaatgtttt 125820
gtgaattaag atttacatca agaatatgta atgttgttac tgtctcccaa atacaggatc 125880
tttttctgaa tataaaagtt atacatgcta attgtagaca atgaagggtc attatcctca 125940
tagataatga agtgcttcta atacttgtgc ttttattcat ttattcaaaa agtgctaaat 126000
aagccctgaa ggggcttttg gggggtcatt tggggcttat ttagcacttt ttgaataaat 126060
aaataaaagc acaagtacag tttttttaaa atactgtttt ctataataga ttaatcttaa 126120
atggcatgtt ttcctttatt ttactgacaa aagttactta ctctgtgatt gaataataaa 126180
aattctttgg ttcagctgag agaaacttgc aagctgacgt ccttgattat ttaaaatgaa 126240
agcagctgcc tgttttcatc tctctgcatc ctgaggaaac tcttctgcaa cgtgttccag 126300
ccctaggttc tagctgaccc tgttcatctg tttggcacga ggggcccaac taacacttgc 126360
ggctacctgg acgacagcca atctagttgg aatgagagtt agaggccata gtctgtcagc 126420
tgggaaagca gcttttattc caaggtgtgc caaccgaaag gccacatgtt attgtcacaa 126480
cctggtacct acatcagtgc tgacatcttt aagaacctta gaattgggaa atcagtttag 126540
ccctatctgc atgtgtagcc gacaaccaca caattgttcc aacttgaggt tgcattcaga 126600
gcaacctcat ttcccccata ctcctgagga aaagcagacc agagacgctg ggtcaatcca 126660
gagttatggt tggaaaaatg atggaataat tctgcccctg gtgataggag agagggactc 126720
catcttgtca actgtcatgg ttcccatgtg aaagctatca ttatcactga aattgaatga 126780
gaacacagaa gggaagaaca gggaaatccc cacagagtta aagaggatgt gaagattgct 126840
tcatgtttaa tgtttgtgta agtgctttgg gttggttatg tgctgtctga acatgtgctc 126900
atttccatgg ctcattgaga gggcagacag tccaatgata ctctttagaa tcattcccat 126960
ggggaaggaa caaagaagcc tgtaaaatag aaatgcacat gtaaaaagca ttgaagaaag 127020
tgccagtgta ttgattttgg ccatggtttg tgctctacca cctggttact gtgattgcag 127080
aagtgccttt gcagatgagg aagaacctgg ccaaggctca atccaacatc caaagccaga 127140
ggccatattt cttcactctt aagataattt gggttcaaat tatagtccct ttacacactc 127200
tctgcctcaa aaggcccaag actctctttt gttatgcttg cctaaacatg cctttcaaag 127260
aactagttct gtaaatacaa ctttattata aacctctcct ttgcttttaa aaatggatca 127320
ccacgtccat ttctatggtc caactttgtc ccttaattta aaattttttc ttggattaag 127380
tttgatgcct tgaaacatta ggaactcaag catacaagat tgtatgctgg tggtgaggga 127440
agtaactgtg cctccgcctg tgctgggtgg atcaacatgg agtgtggacg agcataggga 127500
tgtgtgggtt tctcactagc tgagagtgtt tttaaatgtt gtattttgat gtttgttatt 127560
ttctgaatat tctacagtta gacctttgat ttattctttg atgcattcat ttgaataata 127620
tttttaatct ccagccagtt aggtttttaa tttacacttt tgtccctgat tttaggtgta 127680
gtgttgtgta cactactgcc cagtgtatgt tatgtttgta aacattcatt gcacgcacaa 127740
caatgtgact cacaatattt ttgagaagta aaaagttcat tatatagtta ttaactcaac 127800
cctacagtta tattcgtgaa ataccttgtg aaatttattt tttgcctact ggagctctta 127860
caggttaatc ctgtcttcaa gattttcata gaattttcat ctaccaccca cccctttaaa 127920
tttcaacatt tttttatttt ggcattttaa tgcaattcaa tgcattatag ggacaagcta 127980
tctcttatta tgaattgcac cttatataaa cttaaagatc ttttatcaca aatttctttg 128040
ctgtgtcctt tagtgagaat ttgtattatc agtcactaaa gctcactaag ttagtaagct 128100
ttgcgcccag atgacctggg caggaatggg tgagtctctg tgtggagaga gtgaagaaac 128160
tgctaccctt aatacctgga ccttgaggga ttgttttatt ttagtttttc tgcatttctc 128220
agtatttcat gtgatatctg tctttttctt ccagtttgcc aaggcacgag taacaagctc 128280
acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt 128340
gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc 128400
ttaaaggttg gtgactttga ttttcctaca caaataaaat tggagaaaat ctaagtggag 128460
aaaggcctgg gcagaattcc acttgaagtg tgtttatttt tgctatggca atgacaagtc 128520
ttacagagct acaaacgaga gttttatgag aaagccattt taccagctaa tgtcaagtaa 128580
taactagaaa aggatatcaa atagaaacag gctaatctgg agttccatgt catcatagac 128640
actgacgttt atccctgacc attacctcag tcatgatgtg ctgccatact cgctcttaaa 128700
aacttttttt aaaagccctg ctttgcacca tttgcctatt cccttagtgt aaatactcct 128760
actatagctg atttcaaggt accaagtttc actcagctgg tcacagaatt cttatttcac 128820
gataggcgct aatgacccca taggagccag ctctgaaggc ttcagagttt cactgaattt 128880
tggatggggt ttacttagcc ttcttctgtt tttcttttac ctttcctttt taaataagaa 128940
ataatgcaag acagatacaa agtaattctt tttaatttcc attttcactg gagagtgttg 129000
aaccccgtga ggcatgagag cacagtgttc cagaacaatg cttactgctc attatcacag 129060
gggtcaaagg ctaacgtgca gggattgttg cagatcgtgg acatgctgcc tcctgtgtcc 129120
atgactgcaa tcgtctacct attttacagt tgttgagcac tcgtgtgcat tagggttcaa 129180
ctgggcgtcc tagggctccc tggacccatt ttagaccttg agttcttgag ttcctcaaaa 129240
gagaaatcac gcatttatgt tttctcttct tagaccatcc aggaggtggc tggttatgtc 129300
ctcattgccc tcaacacagt ggagcgaatt cctttggaaa acctgcagat catcagagga 129360
aatatgtact acgaaaattc ctatgcctta gcagtcttat ctaactatga tgcaaataaa 129420
accggactga aggagctgcc catgagaaat ttacagggtg agaggctggg atgccaaggc 129480
tgggggttca taaatgcaga cagcagttcc gatggctccc agcgagcttg tcactcaatt 129540
ccacctcgga gaaggctttt atttttaccc agtacacgtg cactgagtgc cggctgtgtg 129600
taagatactg caggggaagt tactgagaag atggcagata ctggaatggg aagatttaag 129660
cggggtacca gtgtttacat ggacatgaaa aaatactgag agatagtaag aaatcgtaaa 129720
gattctgagt aaaagagagt atgaccaaac aagctgagca ggaatcgtga atctatgtgt 129780
gtaggcagtg aataaactgc cagtcttatt acctggacct caaggataaa agacatacag 129840
taaaaatcaa cccacattga ggacagtttc gagagtcgcg ctgctacaca gaaagccctg 129900
tgtaagttaa ggatagagaa tgaggtgttc tagaactttg aatttttgtg agcaggactc 129960
gtgaggttcc tgtgagagga aacaatgaag gatgatagaa aagaagggaa attgatttta 130020
aaaaactgga gatagcagtg attgtgcctc actgtgcagt gggtttgggg ccaggaatgt 130080
taaattggta acttcattta acgcccacaa cctttcttca aagtaggcac tgtacagatg 130140
ccccttgact tatgatggca tcctatctgg ctggaccccg ccgagggtga aggcgtcatt 130200
aggtcggatt tcagggctaa ttgaatgtat attgccttca caccatggca aagtcgaaaa 130260
tctgtgttaa atcatgctaa gccggggact ggctgtgctc tgccatcgta caaataaata 130320
aatggaagtc aagtaactcc cttgagggcc ccagctagtg aatggagagg ccagctatgg 130380
ccaccactct ctgccccagg gcgctcaacg cccctcctgt gccatgcagt tctgacaggg 130440
aggcagtgct ggtaggaaag gggtgtgatg aaaggggtgc ccagcagagg gagtcatatc 130500
cggagtgaca ggagcccaac aggggtgcag cgctggaacc caagccagca cctctggtca 130560
tggctcctca gttcaccgcc tataaaattg tgtggttccc ccacacccct tgctgctcag 130620
agcagccgcg cacatgcttg tgctgtgcgt gcctcctgtg agatggcctg gtacaccggt 130680
tcctacagtg cgcctcacac gctgtctcgg agggaggcag cctgtgcggg tgcctggacc 130740
tccgagccag accctctggg ttcctgcctg gccccgtccc tcagcagcca gatggctcgg 130800
gagcacattc tccaatccct ccgtgtctct gtttcgtcat cttcaaaaat gtggatggca 130860
tagctgctaa aaaatggtga catacttcct aggtggtgca gaaaattaag tgactgtagg 130920
aacaggcctc agcagctcct tccacttcct tggtatgatt gttttttaaa ccaaggctgg 130980
gattgtatag atgcagatta gttaatgtga taccattaat agctaaccta gtgcctgctg 131040
cagggtgagc ctcccctaag ccaccgggaa gcggctcctg cagcctccct cacgtgtgct 131100
ggccctcctc tggcagtcat tgcctgtggt gtgctgaagg cccagctctg actgtgcctc 131160
tgtgctctcc tcgccccgcc ccctgctctc tctcaggtct ttggtctgtt gtccgagctg 131220
ccacagcagc ctggacatcc ctgttggtgt ttccagccct gtcctctcct gagttccatc 131280
cacctgtgca tggctttttc atgagtgttt tcacggatgg ttctgctgtc atctccaacc 131340
tgataaacaa agcaccacga ttcagccctt atgaccccaa gcttccttcc tcagttcctt 131400
gcttctgtgc atccactgaa gaagcctgtt ccactgtttc cctgcactgg gtctcctgtc 131460
tgcaggaagc cttcagccct cacttccaca ctcctctaag atgtgtgcct gtgcccttct 131520
ggggaagctc attttcctag cagcctccag gatcttcagg ggtgaatccc tcctttccca 131580
cgttggtact ctgtacacac aacatgccca ttccctgcct ggggagctgg gcattgcttc 131640
atgaatcaga ggtcaatttt ttctctatta aagtcacaga tgctcattgc accattgtga 131700
gaatgaatga agatagtgct tataaatcag ccagcaaggt acccagcctc actgtgtcag 131760
ggtctccctg ggcatgaggt ggttagagtg tgtgacatgt ctgtccccaa gcctgtcagc 131820
tcccagatcg aagccagtgg atctcattca tcctcgcagc gcccacagca cttgcacagg 131880
gttttgtaca cataagtcat tctgtcaatg ttcatgttta atgtcatcag tggaacactc 131940
ccactttgta aagacttgaa tgtgttcatc cctgactttt ccacatcttg ttagttcttc 132000
tttggaaaca gctgtacagt ttcaccatcc tgtgcatccc tggagtctac ctgtctctgt 132060
catacattca gattcttctt gtttcgtgtc actctcatat ccttttctct aatgaaaagc 132120
tccgcctggg catgcaaggt ggagccctgg atgccagccc ctcacctggc atccagggct 132180
gtagcactca ggaactgcct ccctgccctg cctaccccct acatcatgcg accattccag 132240
tccagccaat cagccccttg ggacccagct taccacatgc atatcattta tgctgtgacc 132300
actgactaaa ccattctctt ccttcctccc catatttcta aatttctaat cattgctcaa 132360
agcccaattc agagaaaacc ctagctcctc catggcacca tcattaacaa ttttatctgg 132420
ccgccccccg ggaagttcac tgggctaatt gcgggactct tgttcgcacc atggcatctc 132480
tttagcagaa cataaatgcg aagagcacat gcatccttca tgggaattta aaggagctgg 132540
aaagagtgct caccgcagtt ccattctccc gcagaaatcc tgcatggcgc cgtgcggttc 132600
agcaacaacc ctgccctgtg caacgtggag agcatccagt ggcgggacat agtcagcagt 132660
gactttctca gcaacatgtc gatggacttc cagaaccacc tgggcagctg taagtgtcgc 132720
atacacacta tctctgcctc cagctcctat gggggacagc tctacagcac tggggcaggg 132780
gagagaagcc atgtttagta agtcacatta atcagaaaca aaaagtagta agcaaaatat 132840
ctgaccacta gaaaagcatg tatttaccac ggacatagag atcgtttttt tgtggcgggt 132900
ggcagcccag ctggttggca gtgcaggcca ccggaggcag atcccctgca gggacagcag 132960
agcacttgtg tcctgagaag agctgctgtt catggggctg gcagcaccag ggcctctcct 133020
agcctgccct gctgacactg gccagactcc tacatgcttc tgagtctcca gaggctaccc 133080
ggccctcctg aagcaccagg gctgaatcca cccccagctg agggcatgaa cactgccaca 133140
tggagtcaca cacacagctg ggcactgcca tggagaggaa gtctgtccat gtttccttga 133200
atactggtgg cctggtccct gtcccattcc ccagtgaggc agcctgtggg gaagcctggc 133260
agggaaccag gcgcaggtca gcgtggcgcc ctgactcagg ccagcactga tgggggactc 133320
tgagacgcaa gctcacactc acccagctcc cctgggctgc gcccgttcct gatcgcttgg 133380
actttctgtt ctttagagta agaagtgatc accatttcct gcttctttgt ttctccacaa 133440
ctgtgcagtg gatgcctgtt tgttttctgc cctcagaaca aaaaaaaaaa aaaatagagc 133500
tgacgtgaat cttcaaaatc atcaactaca gggctttgga tttttgtgta tttgttttat 133560
tttcatttta tggatggatt gtgatgaaat gcccgtaata caagattttc catcttaacc 133620
attgtaagtt acaatgtcag tggcattata catccacatg ggtgtgtggc catcaccacc 133680
gtccacacac agaactcttt tatcttgcaa agctgaaact ctacccatta gacagtaact 133740
ctctgctctc ccttccttcc cagcctctgg ccctggcagg caacagtcca cttgatgtct 133800
ctatgaattt gactgctctg gggctctcat acaggtggaa tcatgtagta tctgtccttt 133860
tgtgtctggc ttatttcacc tagcaaaatg tcccgaaggt ttatccatgc tgtagcacgt 133920
gttaagaatg tccttcctct tcatggctga ataatattcc attgtatgtt gacactacat 133980
tttgtttgtc cattcaccta tctacagaca ctggggttgc ttccatcttt tgactgtttg 134040
aataatgctg ctgtgaacat gggtattgag gctctttgtt ttatagacat attattccac 134100
cagataccca tcctgacacc tactatgttt gcaagaaact gaaagcttta ttttacattg 134160
caaaatttca tattatgaga tcaaggttag catttcctca gctgtctggt ggacaatggg 134220
gaggttaaac tgtgcacatt ttattttttt ttaatgaacc tggaacggtt atggggccag 134280
tgtttgccat ggatcaggtc aggcagccca caatggcagg tctccatgtt ctgtacaaca 134340
actgtgggaa agacccacag agaaagtgct ggaaagggga atgatgggta ggttcatgca 134400
gtaaaaagat tcaaatacta cagggcattg aactataggc caatatagca ttgctttaag 134460
aataaacaaa aaataagaca gtaagaataa gcctagcaaa atcaaaagtc tataaagaac 134520
tgacatttca agccaataag agaataattc cttattcaat aaattgtctg gaatgactta 134580
actattaggg gtgaaaatat caaagtgaga gaactataaa gggtttttaa aaaggaatta 134640
ggtatgttgg gttagtcgca ttggagagtg caaattcacc atcgacctga tacctgaaat 134700
ttcctcctta ccatctagag gcaagttggg aatgctgcca ggctcctgtg gtaaaggaag 134760
ctcctctctt gactggtgct ttatggctac acgttcctgc tcagaatgga tctcatttag 134820
tcttcaccaa aaaaaaaaat ctcatgagat gatttaagtg ttttatggac aagatgtcta 134880
aaactcagaa aaatttcaca gtgtgcctag cttttatgtt tatgttgaag ttgggcatta 134940
gaagttagaa tgaatgggtt tacttcagag aaaattaaat ccatcaccca ctccttgtac 135000
tatgaattcc aaatacatat taaatacata taataaaata tttaatatat atgtaagtgc 135060
cagaaggaaa cataaatatg aatattttgt aatatcaagt tgaagaaaag ccaaaatctg 135120
acatcataaa agaaaacttt caagtaaaat atgttaatgg ctaccaggaa aatattgtgc 135180
aatgtctgat tgccatgaag agggttaata tccttgctat atcactctgt gaagtcatct 135240
ttaaaagact aagaaaaaga tgaatctctt aataaaaacc tggcccagaa catgagcagc 135300
ctctctctct cactctcact gtctctcttt ctgtcacaca cacacacgca cacatacaca 135360
cacacacaca aatatggcca agaaataaag taaaatgtta tttctaatgt aataagtagg 135420
tcaaaataga aaaagaaagc atcacacctt cctttgcaaa gtatttgggt tccttttgct 135480
tttaaacacc tgggtcagct ggggtgtcga gaaacagaaa ttctcacgtt ctgcttgtgg 135540
gcatatatgt taataaaacc aagcttggca atatgcctgc aatatgtatc taaagcttca 135600
aagtatgtat agctttgacc aatcaatatc acatttcgga ataagagaaa aagaaataat 135660
gaaagtgaaa atcataagag atgtagaaac atattcttat acaagaattc cttgcagcct 135720
tatttataat aaattttgtg aacaaattat atatctaaaa ataagagatt ggttgaaaaa 135780
attatgcagc agccatgcta ttgataatca tgttagatag aagcatattt aaaggcatgg 135840
aaaaattgcc atgttttata tgggttttta aggttataac acaatgtata gtgggattcc 135900
aattcctgta tatacataga cttatatgtc tatattgatt aactctggat gagtctcatg 135960
tcttcttttt gctttcttct attatccata ttttatacga tgtgcctgca tttctttttt 136020
gtaacagatg gtcaatacta gaatcataaa cagatcttgt ttgtttattg gcaaatgttt 136080
cccgttagaa aaagatgcat ttttctttta aatattttta ttttatacaa tgattacaag 136140
cttataatag aaatttgaaa attatatgtg agtacagggt aaaaagttga aagaatggga 136200
ttgcacgcta cagatctagc tgcttttagc acgcctgcgt aggaccttgc tttctctaga 136260
cctctgttgc agtctctctg cctacctcct cacaacgtcc atcccccgcg gtcactgtcg 136320
tgatgccagc ctccccggcc ttcatgtctc taaggagcac cagcgcggca attagcgccc 136380
tttgccttgg tggtattctg gcttcacagt cacatgggag atcaatcgtc agcttttctg 136440
tttgaaatct aaattcttcc tgactgcagg ggacctcggg acccatgaac acctctagtt 136500
tactatgtct tcacagtaaa agatatctgc atgactggac tctttaacaa atttggtggt 136560
taacctactc tttctatata gatatagcac ttcgaccttc agacttctca atactgataa 136620
aaagaaaaca cgacagatga caggaaaacc tttgcagcta taatttgtaa tcggccaatt 136680
ataaaaactg caaaaattga ccagatagct aaggttttac acagtcatga aagtgatctg 136740
cactgttaac atttcaccct ctgtgcacca ttctgtgctt ctctctggtt tggagtctag 136800
aaggttttat ttacaggcta tgacttaaca atcccagaac ggctgacaca tgcagtcact 136860
caagactgga cacagcaagg aagtagtggg tccatgccaa aggctcagcc agacgagaca 136920
ctctagctgt ggcaggagat gccagggaat gctccaagcc taagcagatt gtaaacaagg 136980
aacctcaaat tcatgaaaaa ttcttgctta tgtggcccat gtcagtaatt actctctgcc 137040
tcagtttccg cagctgacat gtaaataaaa gcagttcatg gttcatcttc ttttcttatc 137100
ggggtctcaa gtgattctac aaaccagcca gccaaacaat cagagaataa gttgaaaaga 137160
ttgtcttcat ttattgaatg tgcttaactc aggcccggga aagggcgtca tcagtttctc 137220
atcatttcac tgagatatgc atctattact tttacatttc aggccaaaag tgtgatccaa 137280
gctgtcccaa tgggagctgc tggggtgcag gagaggagaa ctgccagaaa cgtaagtcag 137340
tgaacagcct cagacccatg tgtgaccgcc cctctcttcc ttcacttgct taggtgattg 137400
gatttgtttt ccctctgaag actccaaaga gttactttat tacagggtca gatgtgaacc 137460
agtaggtgaa ggacagtctt gcaaatctca ccgcatgcag ttaatccagg gtgggctatt 137520
ttgggagctt cagcctatca caaataagtg aacatcagca ggggctgggc gcggtggctc 137580
acccctataa tcccagcact ttgggaggcg gaggcggtcg gatcacgagg tcaggagatc 137640
gagccattct ggttaacaca gtgaaacctc gtctctacta aaaatacaaa aaattagccg 137700
ggcgtggtgg cgggcgcctg tagtcccagc tactcgggag gctgaggcag gagaatggca 137760
tgaacctggg aggcggagct tgcagtgagc cgagattgtg ccactgcatt ccagcctggg 137820
cgacagagcg agactccgtc tcaaaacaac aacaacaaca acaacaacaa taagtgaaca 137880
tcagcaagta ccccagccct gtcctctgaa cacagcacac tttcccagga atggaagact 137940
tgctcctgtt gacagcagtc accagacttc ttgtttcctc tccctccctg gctttctttg 138000
gtacccacct acacagaagc ctgagcacgg gttctcatgg ggacttttcc atgtggaccc 138060
tgctttacga tggagagggc cattctccta ggtatggttg tctggctcag cctctcagtg 138120
gccaaggaac ctggggacat gagctcaaaa acggacacta tgtccttaag ctgaattgtg 138180
ggggggctgt taggcccttc taaacactac ttcccagcag gtatttttgt tctttgtatg 138240
tgctttctgc attgcccaag atgcatctaa ttatttagca ggtctcaaag tctagacttg 138300
atctcatgag ttctcttaag tgattaaaaa taaatcagga gaaaaaagag gcaatcagaa 138360
aagggcatgg tttgacttag tttgaatgtg gtttcgttgg aagcaaatgt gtcttcactt 138420
tttcatgaaa aagtctgcaa gtgctctgcg acatccctgg gaaatgatcc taccctcact 138480
cttcagctca cagggaacct ttgctctttt tcagtgacca aaatcatctg tgcccagcag 138540
tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca 138600
ggctgcacag gcccccggga gagcgactgc ctggtaagat gcccctccag cagcctccct 138660
ggagcaggct ggggctgcac ccgccccacc cacaccagga cagaagactt cctgtggggg 138720
agctgtcaat tagcatttgt cataacagac aggatattgc cctctgcctg gtgacaaagt 138780
atctttagta tcctgcctcc accactcact gagaccttgg gaaaatgatg ggactaccat 138840
gcctccattt ccttacctga caatgatgca taacaaagtc tctcccagtt gaatgcttaa 138900
atgatgagat gcctgtgatg tccgtcatta ggacctgggc acagaacaag cactaaatac 138960
tacatgcaag tatttgtcat gaatgtgcct tgttgccagc agcacactct ctttattgtt 139020
tgacttcggc tatacctcta gagacttgac actgtgaggt ccctaagaga cccatggaga 139080
gccacacagg tcttgctggc tggggctggg ttagggcctc ctgacacgga tccctcggct 139140
cctccaccac tgctcaggca cctcctgagc tgcaccctgc cctcaagggg tcctgaagta 139200
ctcactgtcg ccccattgct ccagaaagtg ccagcagaag ccttgctgcc ccagcgggct 139260
ctgagcagca ctggagggta caggtcagaa gcgtcttgga agtcctggag acgccaaggc 139320
tggtggatgt gactcctgga gtgggagctg gtgtgacgaa gcccttccta agactaaatc 139380
cagagcactc tgtggtttca gagaagattc ctaaattcca gagtttggac ccagacccag 139440
gaattgtgac ttggttggcc tgagctgttt ctaatgtgag ccccagggag aagactgtgc 139500
gtggggttgg tcctaggaaa agccctcgct gtattgggtc tggctccttt acacggcatt 139560
gttctagcaa ggctttctgc cattcagcaa tacattataa aatataccct caattgtact 139620
ttataaggga agcccaatgt cctttataag ggaaattaaa cataatttca ttccatagtc 139680
accgctataa tgtgtgaact ccatcatcta tacgttagta aacagacgta tttttatcat 139740
aatccataaa ttatgatagg tgggacagtg cacctaagaa aaaaatggac tttttagaga 139800
agggtctttc tgactctgca gagggcgcca gctgggtttt cccacactag tggaacacta 139860
ggctgcaaag acagtaactt gggctttctg acgggagtca acaccgtgct gcgcttcctc 139920
cgtgtgtggc gctgagtgta cttacctcac ttgcccagcg tgtcctctct cctccatagg 139980
tctgccgcaa attccgagac gaagccacgt gcaaggacac ctgcccccca ctcatgctct 140040
acaaccccac cacgtaccag atggatgtga accccgaggg caaatacagc tttggtgcca 140100
cctgcgtgaa gaagtgtccc cgtgagtcct cctctgtggg ccctctaact ggtcaggcat 140160
ccttgtcccg ctctgtctcc tgctgagccc tggagtatcc catcttggag agtctttggg 140220
tggatgtgtt tgccttgctt ggaggaggcg accctgtgcc cgtccaggca cacaggcgag 140280
gggaggggct ggcttgctac cgaggagcgg gcaggtggtg gccatctcca cccatggggg 140340
ctgctcagtg cacagggcag atctgggtgg ccaggccacc tcacaggaga aacacctgct 140400
gctcagccct caccactcat ccagcagcca cagccgtggg tattcagttg tctgctgggc 140460
acaaagccgt gggcatgcca ctgtttagtg cttgtgccaa gcaggtattt aatacaccga 140520
aatcagagag tctatcagaa gacctgcctt cttgagtggt taaaattcta gtgaaagtta 140580
tgcctcttag gagtattgca gaggttttgt ttttgttttt attttgtttt gttttaatgg 140640
tttgggtttg agttttgctt gtttgtactt acatttgtac tggtggctcc agggtttagg 140700
gaaattgtga cataaaataa ttcctgacag agaaagcaaa actttgtcta atgaaagagt 140760
tttagaagcc actcttgatc tctagaaggg gagattaact gagaaaaaaa attgaaagaa 140820
caattatgag ggggagattt taccctgcca gatttgtgta catgaaaaat tttacattcc 140880
gtatggaaaa aaaaaacaca aaataataag ccattataag gtaaatgaca aacaaagcta 140940
aagaaaaatg tgccacagtg atgacacaga tatatctttg agatagggct taacagagct 141000
ttaaaatcca taggaaaaca cttcgagcct gagataccaa gagcagatgg ttcacagaag 141060
aatcatcaat gtcctataaa tatttttgag gatcttcttg gggaacttaa aacaggaaca 141120
ggccaggcac agtggctcat tggctcatgc ctttaatccc agcactttgg gagactgaag 141180
gggctggatt gtctgaggtc aggagtttgg gaccagcctg gccaacaggg tgaaacctcg 141240
tctctactaa aaatacaaaa attagccggg cgtggtggcg cacgcctgta atcacagccg 141300
ctcaggaggc tgaggcagga gaattgcttt aacccaggag gcggaggttg cagtgagctg 141360
agatcacacc actgcactcc agcctgggtg acagagcaag actccatctc agacaaacaa 141420
aaaaggaaga catagagctc ctaaaaataa cgcagaagtc tgctattaat acaaatgaat 141480
tactttaaag gtgagagcag gtggaggaga gggctgaggt gcctgctggg acgcaaaaca 141540
gctggcccct caagggaccc agtgtttcct gccatgatga aacacctgta ttgtccacat 141600
tgcggcctag aatgttatta aactcttgaa cgggattcct tctctatttg caacctttca 141660
ttctttgtcc ttaaagtaaa taaagccaaa ggaggatgga gcctttccat cacccctcaa 141720
gaggacctgg accgcctgtg tgaggcccga gcacctggtg ccaccgtcat caccttcctt 141780
tcatgctctc ttccccaggt aattatgtgg tgacagatca cggctcgtgc gtccgagcct 141840
gtggggccga cagctatgag atggaggaag acggcgtccg caagtgtaag aagtgcgaag 141900
ggccttgccg caaaggtagg aagcccgccg gtgtgcggac gaggcttgtt ctcggctgct 141960
gaggctgggc tctcatgcca cctccaaagg aacacatctt cctcttctca ttaaaaaaca 142020
actatacata tcgtttcttt aaaacagaag ataaagctgt aaagctaggt taggcaatgg 142080
gaaggcactg aaggttgtga cggggtgggg ggctctgatg agaacagtca cagagccagc 142140
cccgctcagc agctgccagg tgcccagccc tggggagaat ccagggaagg cagagctgga 142200
agcagtgcag ctccaagcgg cccatgggaa ataatgagga gaacgcaagg tcagtgtgag 142260
gtgacaggga tggcatctcc tacaccgccg tagccccaaa gtgtactata ggtcctggtg 142320
tccccccttc ccgcctgcac tctccccagc cccttcagtg tttgttgagt gaatgaagga 142380
tgatgtggca gtggcggttc cggtgaccgg aattccttcc tgcttccctc tgcctgtgga 142440
tccctagcta ttcttaatcc aacaaatgtg aacggaatac acgtctctct tatctctgca 142500
gtgtgtaacg gaataggtat tggtgaattt aaagactcac tctccataaa tgctacgaat 142560
attaaacact tcaaaaactg cacctccatc agtggcgatc tccacatcct gccggtggca 142620
tttagggggt gagtcacagg ttcagttgct tgtataaaga aaaacaaaat ctgccttttt 142680
aactggtaga gattggtgat caataatcac cctgttgttt gtttcagtga ctccttcaca 142740
catactcctc ctctggatcc acaggaactg gatattctga aaaccgtaaa ggaaatcaca 142800
ggtttgagct gaattatcac atgaatataa atgggaaatc agtgttttag agagagaact 142860
tttcgacata tttcctgttc ccttggaata aaaacatttc ttctgaaatt ttaccgttaa 142920
tggctgatgt tttgatattt ttcaaaagtg cagtttctcc tgcaggcaaa aggggacacg 142980
ttaagtccag gcttgggtca ttcactgcgg tgtaaacacg ctttctccct cccgcccggc 143040
cccagccagc tgccttggtg gcccataacc cctgagggta gagggagggg acaggggtag 143100
gtgacaggca gcctgggcct caggcttttg aaactggacg ccagagcctt gtggggccac 143160
gggcaagcct cgggtctatg actgccgcct gagctccgct tccttcctct ctaaaatggg 143220
aagattagac caaaataaca agactgtttt aaggttggaa tcaaataagg aaaatttgta 143280
aagctccttg tatgtgatac cagatccaca attggcagat aatcgcagca ggagcctctt 143340
cggggtaatc agatacgcgg cgcagcaggg gtctcagggc cacagccagg ggggcggcgg 143400
gagacatgcg gaatcgcagc ggaaggcggg aggcagctgt gaactgtggc tcggcctgcg 143460
tccgccctgc gcatgtacac tcagagaaga tgataatgaa aaagaaagca aatccaattt 143520
tcccacttac tgttcatata atacagagtc cctgagagtc tagagtaatg tctcatacaa 143580
aaaagaaact cctacgtggt gtgtgtctga agtctttcat ctgccttaca gggtttttgc 143640
tgattcaggc ttggcctgaa aacaggacgg acctccatgc ctttgagaac ctagaaatca 143700
tacgcggcag gaccaagcaa cagtaagttg accacagcca aagcctggta gattacattt 143760
gcctttttag ttggaaatta ggcttaacag gagagttgct aagatagggc acagagctcc 143820
tgcatctctc gccggcattc ccaaatgcta tctcacatga gcaggcacag ggagcaagac 143880
tgcacgacca ctggcacagg ctgtccgcta aaccacagac ttctcagcgc tcgccagtgc 143940
ttctgcttct gtgtccactc cagatcccac attgcactta gttgtcaaat cttttcagtc 144000
catttctaac ctatattagc tcctgtgtct ttccttgtct ttcacggcct tgacacttac 144060
aaaacgtgtg ggtcaggtac tttgcacact gtctaaccat gtctgttcag ctggtgtttt 144120
ctcaggatgc aattgaggtt atgcacatct tatcacaggg accagagaga ctttttagca 144180
ccactcttca agaatttcca ctttttcagc tttgacagtg gaatagacat gcaggtgctc 144240
acacacaagc atctttaata tggtaatggt aatcatcagt ttagtggtgt ggaggaggag 144300
atgggaatct cttagtgaaa cccgccttgg aagcagcctc gttatgagaa ctgctgcccc 144360
tacttgactc ttaaagcact agataatact gtgcaacatt aaagagaata agagtgcgtg 144420
aaatatgcat tgcctcccat aaactccctt ggctctgaat ctctgatact aaatatgtgg 144480
ctaccgttgc ttcccagaaa ggcctttttg ctctgaattc tctggaatgc tttctttgac 144540
caagattctt ataaaaataa gagatttaga gcaattttct tggatggctg gtatgagcca 144600
gttggcttag ttgtagggat ttaaacaaga taagggttac ttacttttca catttaatga 144660
gaagtctggt gattccagct cctactgaga cagggtggcc acacgttcca gggtgtgact 144720
cactgaggcc ccagacctgc cctgcaagga aaacctggct ctgccctggt gtcctggcct 144780
ccctgggcat atgtggggga gaattcctaa tggtattggt tacaggctcc tatgcgagac 144840
cactcatctg tgtaggagaa aggaaaaaga tgggggaaag aagagcagca gggagaggag 144900
aagcctctgg atgatactct aaccccctgc catccaacac ctgaacatca gtctcttcat 144960
ccagtgctct cagctggccc agcccccagc ctggggtcag atgagagctt cctgcaaatg 145020
cagatctctt tcctgtggct ccttctcaat tacagacagc tcctccacaa ggtgcactct 145080
ggccttgtgc tccctcccca aaccagccca gccctcccag cctgcatcat cgtggtcctg 145140
taggggctag aggttctcac acccatcgtg gtctggcaga ggctggtggt tctcacaccc 145200
atcgtggtcc ggcaggggct tagtggttct tatacccatc gtggttcagg aggggctagt 145260
ggttctcaca cccatcgtgg tctggctggg gctagtggtt ctcatgtcca ccgcgtgctt 145320
tcctgctcct ccaggtggct gaggacatcc ccccttcggt ctgaatgact tccatccagt 145380
catctgatat acacattgga ccacccaata gcatcctagt gtcatgttgg atggtgaaga 145440
aaatgccaca gttactgctt tcagggcctc acaaccttgg gcatagcttt ttggaggaag 145500
gccccacttc ccaggcatcc ctcccagacc tggtcagagg cccctgctct ttgcttccat 145560
gttgcccaca ctcactgtgc tcttcacacc ggctcaaaat gatctgctta cggggttgtg 145620
tcaccaccag atcaagcgtc ctggagagga ggaaacatat ttaacctgca cagaatttgg 145680
gacagagaac ctctagtgtt tgttcaataa atatatgaat ggatagaggg acaggttggg 145740
tggtggatag atggatgaac ccacaccttt gaagtgtatt tggctgtttg agaggttaga 145800
atatgttctc aatttccagg caaaatgaaa atggagaaaa tataatgaca ttaaggcatt 145860
ttattcatcc tccccatctg ccactgggtt aaagatacta aataaacaag gaactatctt 145920
ttgcctggag gaactttaaa aacacctgca gttttcaaaa ggtgcagtgt gtgcctccca 145980
cagcatgacc taccatcatt ggaaagcagt ttgtagtcaa tcaaaggtgg tctggagaaa 146040
caaagttttc agggatacat tgtttttata atttttcacc acatgatttt tcttctctcc 146100
aatgtagtgg tcagttttct cttgcagtcg tcagcctgaa cataacatcc ttgggattac 146160
gctccctcaa ggagataagt gatggagatg tgataatttc aggaaacaaa aatttgtgct 146220
atgcaaatac aataaactgg aaaaaactgt ttgggacctc cggtcagaaa accaaaatta 146280
taagcaacag aggtgaaaac agctgcagta agtcaccgct ttctgtttag tttatggagt 146340
tggttctaat gggtccttta tttgtattta gaatattgaa gggctattcc catttaaatt 146400
acttttttca gttccttaag aagcaaatta aaatcttaag attcctaact gtgaaattac 146460
catgtgaatt ccattaaaac tttttccaga tcattaccat tcaatgggat gaatttaccc 146520
tgaggtttag gctaccaatt atttgtaatg taagtaacta aatttagtat tagttatatt 146580
accttttagt tgtaggtcac tctctgctca tttcagcctg taaagactac agctacacac 146640
atacacacac agaggaatgg aatgagcact ttacatcaac acttcctgtt ctggctctag 146700
agcctcagct tttgaagctg gtgagagcct ggcctgtgct gggccttggc cacgggcagc 146760
gtcagctttg agtcaagtgc tggtctggcc tccctagctt tgagcctctg tcaattccct 146820
taatctgttt aggctttggc ttcctcatcc atagaatgga gatatgaatg attcctacgc 146880
cgtagtgctt tgagagaatt cagtgaaatt cctgtgtgta aaacccttcc atggtgccta 146940
gcacacagca cacagccaat ggcccaatgg ctcctatcag ctgtgggatt tgtcatcaga 147000
acaccaccag ctctgctcca ggctgccctg ggtaccatca aaacacaccc tgtgcccagc 147060
agcacctgct cctctgcaca cctggttcct tcagcagggg cagtggccgt gggagcacag 147120
aaaacatgga gtcccatctg gtttaattga tgccattgcc aaaggggagg actcacggca 147180
ccccctctcg ggtgccaggg tgcctggctc ccaccaggag gaagacctgt cctccactgt 147240
caggcacatt tcagtcttcc cagcagccag cacaactact ttgtccttcc agtcacggtc 147300
ggcctctggg aagcccagtc tgtgtcctcc tccttcaggg gtagccagca tgtctgtgtc 147360
acccaaggtc atggagcaca gggcccctcc cgggaaggtg ccgtctcctc cggcccctcg 147420
ggtccctgct ctgtcactga ctgctgtgac ccactctgtc tccgcagagg ccacaggcca 147480
ggtctgccat gccttgtgct cccccgaggg ctgctggggc ccggagccca gggactgcgt 147540
ctcttgccgg aatgtcagcc gaggcaggga atgcgtggac aagtgcaacc ttctggaggg 147600
gtaggaggtt atttctttaa tccccttgcg ttgatcaaaa ataaggctcc aggttgttgt 147660
tatagcttta caggcattct gtttgatttt ctcttccttt tattctttgc ccttggcttt 147720
tggaggtttt gggttttctg tggggagacg ggaagttgtt tgattgcgtt atttttggca 147780
aatttaagca caataggaaa taagcaagta ttattgccta atataatcca ataatttata 147840
gaatctcttt tcctggaagt atcttaaatt tttctaagct acaaaaagtt cctaagacaa 147900
atgagacagt catcaatggt tcatctagcc aacaccgtgg ccatttgggc ttttctttgt 147960
agtgcccgat tcctggtgtg tgaaaataaa ttaacacaaa ttatattgcc aagttaatat 148020
ctgttttatg tgcccccagc atgtgttgaa catcaaacag taccagggac tttaaatata 148080
cccacggaca aagaaataat tcataatgat gtttgttgaa tttagttgca atcaataaaa 148140
agtgcagttt gtgaatgctc tgaggttctt gatattgatg taaggctttg aacgacaaat 148200
gaggacaaaa cataaatagg aaagtaaaac tgaaggatag aggccaaggc catgttttag 148260
aagatttaaa gaaaaaggga aatttggtga gcaccatagg aattacagat ggctgtagga 148320
attcttcctg ttttactctc tgggcatgga ccacagcttg gatccagaaa tatttaggag 148380
caggataaga ggaccaagtt caattctata ggaatccttt agctgatagg ctcagaacaa 148440
atcacataat tgatagtgct gcttcaactt caagtaagga atattgatgc aatccttaca 148500
gctacaaatg gacagtggtc tcatgttttc agttttcaag tgtttcttaa gaggcaaggt 148560
gatgaaaacg cccacgtggg gagccccatg tccttccatt agtgtagaga aacctggtgt 148620
ccagcagcac ctgctccctc tgcaagccca gcccccttca gcaagggcag tgacccagag 148680
aagaagcaca gaagacacaa ccctgtatca cattttgttt aatggtgcca ttgaccaaag 148740
gggaggatga aaggcacaca cttttttgtt gttttttgag acagagtctc acgccatcac 148800
ccaggctgga gtgcagtgat gtgatctcaa ctcactgcaa cctctgcccc ctgagttcag 148860
gtgattctcc tgcctcagcc tcccaactag ctggaattac aggtgtgcac caccatgtcc 148920
agctaatttt ttgtagtttt agtagagacg gggtttcacc acgttggcca ggctggtctc 148980
aaactcctga cctcaagtga tctgcccgcc tcggcctccc aaagtgttgg gattataggc 149040
ataagccact gcacctagcc aaggcacaca ctttggagaa taaacactcc ttgttcgctg 149100
ctggagggta gaactatgct tgactactag gcagagtcca gtcttactga caaacagccg 149160
tacatctgtt ctgtcttttc aatcaaacat cagcttcttg cttaacattg atgtgtacat 149220
cttgagggat gtcaaaatat tgtaagctaa gtttttcata cctgtgttcc acactcacca 149280
tttttagtaa taaccattga gcgagttcat tctccctcct tcctttttct atcacttaat 149340
ctaaaattat catttttcca gcttaatttt gataaccatg aatctggtat tagaggcagg 149400
gaacacctcc tcaggactat cttttctttt atcatttggc ttgcttaccc aatatgcaaa 149460
aactatgctg tagaaaaagc agaaaagata tcttgattat gaatgaagct cctgtgttta 149520
ctcagagaga agatgaccca ggattcagtt aacaaaatca gctgattata ttactatata 149580
gtcctggagt cccaactcct tgaccattac ctcaagttat ttggaatttt gaagaggtga 149640
tttgtgttcc tgcaataatg tctcaggggt gggctgacgg gtttcctctt cctcctctca 149700
gtgagccaag ggagtttgtg gagaactctg agtgcataca gtgccaccca gagtgcctgc 149760
ctcaggccat gaacatcacc tgcacaggac gggtaagagc cccttgctgc tatccacgtc 149820
catttcatgg gaagggcctt cacagaagcc gaacagtgat gatggcccag ggcatcctgt 149880
gtgggcagga cggccatcag agccacttcc cagaggagac ggcaggcgct gacagcgctg 149940
tccgggcagg gtgtcggtga cattagcaca cacattagcc tgcgatgaac attcactctt 150000
tctgctgaca cccccaacct tatctaagct tatcaaatcc tcacatttaa cggaggctgt 150060
tttcacctgg tttcccccat ccctgaccta gtcagcattg ctttatcgct ttcatcaaac 150120
atcctcaaat tcttaacatt agcttgtaat taattgaaga atttttaaag aaattgctag 150180
caaaactttt taaactgcac aactttgtat ctatatgttc aataacatat agatacaata 150240
ttctttacaa taatctttta aagaatatga gtgagaattc gggcccctct cacaccaaat 150300
gtcctgatgt tgttaattct caatgttatt atatagggag ctctgttttc ttgtgagctt 150360
caacagccag ttctaaatct actaactgaa aacatttttt agacattctc taaattgggc 150420
agaagatgac aggactgtgt tttgagggat aggctgccag cgtggctgct tacaaagtaa 150480
agacttggtt tataggtttg catggtgttg ggttaaattt ctgtcattaa aataattggc 150540
gatattgaca tagtcatcta attatgctgg ctctgggcac acacagccct tgagtggaca 150600
aaaccaacat gagagaactt agccaagggg aaagcctttc cctgctggtt ttatttctgc 150660
tacttctgaa gtgtggggca cacaacctga gcagtgcttt tatttgagtc ccaatgcttt 150720
tatttgagtt ttgcaaggtt attccaagtt ttacaaatag aaggtagcgt atgactcagt 150780
ccttgatatg ccaaccactg cacagagact tgccaccttc ctgtcactgg agaaacactc 150840
atgtgggttt tcttaaattt gcctccctct gagcttccct ttaacttcaa ctataatatg 150900
caagaaagac tatctgacca taaatacaca tttgggccaa tcaagatggt tttgccaagg 150960
aaagatgccc acaatggtta agcagaatgc aataatgtag agaatatcat ttctttcatg 151020
ctggtgtata tcatatgcat tcaaaaacag ggagaacttc taagcaacta acagtgacca 151080
tatcaagcag gtgcaatcac agaataactg gttttctcct ttaagaattt ttctatcatt 151140
tggctttccc cactcacaca cactaaatat tttaagtaaa aagttacttc cattttgaaa 151200
gagaaaagaa agagacatgc atgaacattt ttctccacct tggtgcaggg accagacaac 151260
tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga 151320
gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac 151380
ctgtgccatc caaactgcac ctacgggtga gtggaaagtg aaggagaaca gaacatttcc 151440
tctcttgcaa attcagagat caaaaatgtc tcccaagttt tccggcaaca aattgccgag 151500
gtttgtattt gagtcagtta cttaaggtgt tttggtcccc acagccatgc cagtagcaac 151560
ttgcttgtga gcaggcctca gtgcagtggg aatgactctg ccatgcaccg tgtccccggc 151620
cgggcctgtg ttgtgcaatg ctgcacatca caacaggagg gtagggggac aaaagagcac 151680
aggtcctggc agctgccaca gtctccaggg gcttttgcgt ttctctccag atttctaagg 151740
ttaacatggg gattagctgt tttgcaatga ataaaaggta acattgcctg gaatgttgct 151800
taaagacact tttttaaagc tagttgattg ttaagctgtt gctacttaaa ttaaaactac 151860
tttgggccag acgcagtggc tcacgcctgt aattccagca ctttgggatt ccaaggcagg 151920
cagatcactt gaggtcagga gcttgagacc aggctggcca acatggtgaa accccacctc 151980
tactaaaaat acacctgtag tcccagctac tcaggaggct gaggcaggag aattgcttga 152040
acccgggagg cagaggttgc agtgagccaa gatctcgcca ctgcactcca gcctgagcac 152100
caagagcgaa actctgtcgc aaaaaacaaa aacaaaaaaa aaagctactt tgactggaat 152160
tagcagaagc actctgattg tgtgtatctt atttactgga ataataaagc tgtcaatcaa 152220
actggatccc actcaacaat cagaaagaga agttgagctg tcatatagta gttcacactt 152280
acttctgttt ctcaaaatcc tcagctttgt ttggaactgt tactcattct ttctctgaat 152340
ccatctgtat gagttgtgtg cccttgggca agggtcttac cttctctgtg cctcactttc 152400
ttttctgtaa attgggataa taatgctgca tagctcacag gatttttatg accatgagtt 152460
aagatatgtc atatacttaa aatggtgcct ggaaaatggt gaatactgag tcaatgatag 152520
catcattgat ggtgggatgg tgatgaggag gtgggagtca caatggtggt gttgatggtg 152580
gtgatggtgg tgaggaggtg ggagtcacag tggtggtggt gttgatggtg gtgaggaggt 152640
gggagtcaca atggtggtgg tgatggtgtt gatggtggtg aggaggtggg agtcacaatg 152700
gtggtagtga tgatggtgtt gatggtggtg aggaggtgag agtcacaatg ttggtggtgt 152760
tggtggtggt ggtggtgagg aggtgggagt cacaatggtg gcagtgttgg tggtgaggag 152820
gtgggagtca caatggtggt agtgatgatg gtgttgatgg tggtgaggag gtgagagtca 152880
caatgttggt ggtgttgatg gtggtgatgg tgatgaggag gtgggagtca caatggtggt 152940
gatgagggtg gtgatgatga tgaggaggtg ggagtcacaa tggtgtcagt gttgatggtc 153000
cgatggtgat gaggaggtgg gagtcacaat gttggtggtg ttgatggtgg tgatgatgat 153060
gaggaggtgg gagtcacaat ggtgtcagtg ttgatggtgg cgatggtgat gaggaggtgg 153120
gagtcacaat ggtggtggtg atgacggtgt tgacagtggt gacgaggcgg gagtcacaat 153180
ggtgtcggtg gtgatggtgg tgaggaggtg ggagtcacaa tggtggtggt ggtgatggtg 153240
gtgatggtgg tgaggaggtg ggagtcacaa tggtggtggt gttgatggtg gtgatggtgg 153300
tgaggaggtg ggagtcacaa tggtggtggt gttgatggtg gtgatggtgg tgaggaggtg 153360
ggagtcacag tggtggtggt gatgagggtg gtgatggtga tgaggaggtg ggagtcacaa 153420
cgttggtggt gatgatggtg ttactggtgg tgacgaggtg ggagtcacaa tggtggtggt 153480
ggtgatggtg gtgaggaggt gggagtcaca gtggtggtgg tgttgatggt ggtgatggtg 153540
gtgaggaggt gggagtcaca gtggtggtgg tgttgatggt ggtgatggtg gtgaggaggt 153600
gagagtcaca atggtagtgg cgatgatggt gttggtggtg aggaggtgga agtcacggtg 153660
gtggcgatga tggtggtgag gacgtgggag taacaacagt ggcagtgacg gtgattgaga 153720
catgatgatg atttgtcaac tttctaggaa aacaatcata taatctccaa cagtgatatc 153780
ttaatatctt ttccaaaagt atcagatcat attataaggg ccaagtttcc agaataatat 153840
cagacataat gacagtggac atcagagctt ggcatctaaa ggtaatggga atagctctaa 153900
tgtctcagcg tgaaaaacaa catttgctat tagtctgaga tactaattat ctagttaagg 153960
aagtactcac ctatacctag tttttaactg ttttttaaaa tctggaattg attttgaatt 154020
ttaacaaata tttccctggg aacaatgtaa gattcttcat attttcgcct ttgggtatac 154080
caacatgcca gctctgttgg ccactttgtg agctcgatga agcatggtat aaaagatgct 154140
ttgctagtgt ttcacgtaat ctatttctat aagcaatttt ggagctaagc ctctgaaaca 154200
gaattatatt atctgtatag aataaatgtt ttatcttccc ccttttcttt cttctggaat 154260
agatgtgcat cagtatctct gcatcaatat ctctatatca gtatctctgt gtcagtgagc 154320
atatgttgct gggcttaggg gaggtccaga aagtgattgg gttttggcat tttcaataca 154380
cttactttgt ataagaaata gtttgccaaa tatagaaaga ggggatttag tcaagattta 154440
aattaaaaat gttagtggtc atttttctaa tgtctttcta ttttttccca ggtcctaata 154500
aatcttcact gtctgacttt agtctcccac taaaactgca tttcctttct acaatttcaa 154560
tttctccctt tgcttcaaat aaagtcctga cactattcat ttgacatatg gaattttata 154620
aatattttct ttagtatgtg tgattacatt cctgattctg agccttttta gatgagtata 154680
tagtttgata taatcttgtt attgccacct gtgtcttctc ccaaagccat taattatata 154740
ggaattacac gatagaaatg ggtttaattt ttaaaatacg gccaagtgtt gatgagaggg 154800
aaaatttttt taatttcttt cactgagtat ttatgacgtg cacaacattc ctgaatatat 154860
tgtctctctc atttctcaga tgggatgtat tgccttctcc atttctattg ttaaagaaac 154920
acttacaggg gtttctttaa caacttgtga acagcagcat cagagcccag actacagcat 154980
aagcagctgc tgattccaaa agccctacct tccaaccggg caggtgcagc cacccagacg 155040
agggggagga accctggagg aatagctatt tctttttttt ttttgtcgag acggagtctt 155100
gttctgtcac cctggctgga gtgcagtgcc gtgatcttgg ctcactgcaa cctccacctc 155160
ccaggttcaa gcaattctcc tgcttcagcc tcccgagtag ctgggattac agacacctgc 155220
caccacgcct ggctaatttt tgtattttta gtacagacag ggtttcacca tgttggccag 155280
gcttgtcttg atctcctgac aagtgatcca cacaccttgg cctcccaaag tgctgagatt 155340
acaggcgtga gccactgcgc ccagcaggaa tatctatttt taaatggaac tgtgttttca 155400
tagtacacgg tgaggagaaa gttgctttga aatctttatc ctaataaacc aaataatatg 155460
aaaatttgcc tattttaatt atatgtaaca aagtttagtt actgctataa ttgcaaatat 155520
gtataaattc cttaccaaaa aaaaaagaat caagtgggag ccagagaata atttttctga 155580
cagaattaaa taacatgcta tagctgcttg agttcatact caatagtcat ttctgcagag 155640
ttaccgaggg cctcatcagc gtcagcagga gcccctcgcc ttctgacgct ctcacatcct 155700
tctctcctgc agccccgtcc tgccactgtc cttgtccagc ttctcttcaa gggtcaactg 155760
gtctaccttt ccctacaagt ctgtcacagc ttcttgttag caatccctat ggttgcccaa 155820
aagcattttc agagcctgca taagactgca tcttgtagaa aatttgcagt ttcaatctgc 155880
cctccctctg ccgggtgttc ccattgtatt gcattcagca ggcagggaga gactgctatt 155940
aggtctgttc ctgagtgact gctttctgtc tcagactgtt tggtgtctgt aggaggtagt 156000
ggggtgggca gtaacgaggt ctcctgtata ttccacccct acgaagcctg tgtgtttggt 156060
ttatgaacta agctcaaaag caccacaggg gtaagactgc agtacatgac accatggaaa 156120
agagggagca cccagacccc caaattaaga agagcagtgt agagaacaga gacctggaga 156180
gcagagatag aaactgttag gatcagatta tagtgttaca ccagggctcc ccaggcctct 156240
cacatattga aatgtacttg tccatctttc tccaggccag gaaatgagag tctcaaagcc 156300
atgttattct gcctttttaa actatcatcc tgtaatcaaa gtaatgatgg cagcgtgtcc 156360
caccagagcg ggagcccagc tgctcaggag tcatgcttag gatggatccc ttctcttctg 156420
ccgtcagagt ttcagctggg ttggggtgga tgcagccacc tccatgcctg gccttctgca 156480
tctgtgatca tcacggcctc ctcctgccac tgagcctcat gccttcacgt gtctgttccc 156540
cccgcttttc ctttctgcca cccctgcacg tgggccgcca ggttcccaag agtatcctac 156600
ccatttcctt ccttccactc cctttgccag tgcctctcac cccaactagt agctaaccat 156660
cacccccagg actgacctct tcctcctcgc tgccagatga ttgttcaaag cacagaattt 156720
gtcagaaacc tgcagggact ccatgctgcc agccttctcc gtaattagca tggccccagt 156780
ccatgcttct agccttggtt ccttctgccc ctctgtttga aattctagag ccagctgtgg 156840
gacaattatc tgtgtcaaaa gccagatgtg aaaacatctc aataacaaac tggctgcttt 156900
gttcaatgct agaacaacgc ctgtcacaga gtagaaactc aaaaatattt gctgagtgaa 156960
tgaacaaatg aataaatgca taataaataa ttaaccacca atccaacatc cagacacata 157020
gtgattttaa ttatttaaga gtagtttagc atatattgct ttatgattta attaaaaatc 157080
tccaaaatat atgccaaaga agtagaatga gaaaaatgta tatttctctt tcacttccta 157140
cagatgcact gggccaggtc ttgaaggctg tccaacgaat gggtaagtgt tcacagctct 157200
gtgtcacatg gacctcgtca agaatgacca cactgctgtg ggtgaagatg ctttcctgca 157260
tttctgactg tcctctgtcc tgatcaagtt tctatggctc tgggccagcc taccctcagc 157320
cagggtttct gcagagactg cccagctggt tccacgtggc tccacgtgcc aactttgtcc 157380
tcagtggagg gaaagttgga cacacagtgc tggggctgct ccctgctccg ccgttgctcg 157440
atgcatggcc tgcctctgaa ttccttggtt ccactggttt tgctgggtcc ttctgtgcct 157500
ctagctcctc tttttttctg tccacttacc ccattggtcc catcacaagc ctgtgtgtga 157560
gtggcctttc tgttcgatga caacctccag cataggggag tgtttctcct tgctttcttt 157620
cccagacaca ctgcccagca aaggcaaaag ggcttccttc aacatcagct ctggccagtt 157680
tgccagagca aagccctgag aaaagcaagg ttgaaaagtc ttattcaaac tcaccaggaa 157740
agagtggtgt tactctcgat ggcgtctagc caggaatcat ggaattatac accgagcacc 157800
tgtttgccat tttggatgtt tccaaacatg aaccaaactt ccaggcccct ctgccatctc 157860
tggtaacatt tacaaagtcc cttcctcacc actgcccttc cttcattttg gcatgctcct 157920
ccgcccccga gttgacagcc atagctctct ctcctgccac cagtgtcaca tgatcgagga 157980
agaaggcaac ttcaaaaaga ctgggtcccc ttccactccc atctcttcag tgagctgcta 158040
ggacacccag cagaacttcc ccactccaca ctgcaatctc agggatctta gtcacggggc 158100
tttccaccat gtctccacct ggaaaccagt catggccatt ccttcttaca tctgctcttt 158160
tccatctttt tcttctcctc ctgttcaccc gcccttactc ttgtggcgcc ctatggatat 158220
gcgctccata gcaaatgatt ctttatatct tacggtattc tagtgagctg gcacatgtgg 158280
cttctggttt cctctctctg gaactagaca tgacctctgt gggagggagg attaaatgca 158340
ccctacagtc tgaggctgca tgatgacatc actcatcaca atgatgcttt ctatgtctga 158400
atcctattcc tttataaccc ctttcaagct cgttcagaga gtatttcaca caatccatgt 158460
gctcatctta aaagccaagg acccagagga gtctcagcat tgccaaaaag tcccttcacc 158520
cagcctggcc agaggcagtg cctggtccat gtgtatggac tatggcactt caattgcatg 158580
gaaatactct tggaatgaac aaaataccaa tccatgaaaa agcattattg aagtctaagt 158640
tattttttga atcatatttt gttaatcaac aaattgaaaa atactcatta tatggagagg 158700
tccagataaa gcctcaattt taaaaaatga ggaaaagtgt gcctggtagg ggactgggga 158760
gagcttgaga aagttggaaa cgttgcctta gaagcctgtt ttttctcctt ttagaagcta 158820
catagtgtct cactttccaa gatcattcta caagatgtca gtgcactgaa acatgcaggg 158880
gcgtgttgag tgccaaggcc atggaatctg tcagcaacct cacccttcct tgttcctcca 158940
cctcattcca ggcctaagat cccgtccatc gccactggga tggtgggggc cctcctcttg 159000
ctgctggtgg tggccctggg gatcggcctc ttcatgcgaa ggcgccacat cgttcggaag 159060
cgcacgctgc ggaggctgct gcaggagagg gaggtgagtg ccagtcctgg gtgggctcag 159120
gagccctcgc accccgacag gaacaagggc cagccccgag aacgggccat tagcagttgt 159180
gtatgttaga tacataattg tattatgatg cagaaagaat ctctgaatgt gcagttatac 159240
ccagttggtg acatgttggt acatccatcc gaggaaatgg caatgtttct aggctgcacc 159300
cttcaatgtc cacaaagctg tgtggcatct gcttaggacc cggtgcctgt gtgtgcatag 159360
gagggaggcc aggaagcctg gctgttgatc ccatgctggc actgtggcga aggcgagaga 159420
ttcctgcttt ggaaaacacc attgtccaca cagtggcttt gtccatgatg gacttcgcca 159480
cagcccagtc ctgtgctgga agccatgttc tctggaaaga gcaacccagc ggctcataag 159540
cataagcgcg tgtgatgtgc cccaaccaaa cgaccgccat gcacaacttc cctaccggag 159600
ttttcaatcc agttaatagg cgtggaaaca gacatagaaa ttgtgtttgt tgaaaggtag 159660
ctgttcagtt aaagaacacc tgtatcagag cctgtgtttc taccaacttc tgtcaagctc 159720
tgtagagaag gcgtacattt gtccttccaa atgagctggc aagtgccgtg tcctggcacc 159780
caagcccatg ccgtggctgc tggtccccct gctgggccat gtctggcact gctttccagc 159840
atggtgaggg ctgaggtgac ccttgtctct gtgttcttgt cccccccagc ttgtggagcc 159900
tcttacaccc agtggagaag ctcccaacca agctctcttg aggatcttga aggaaactga 159960
attcaaaaag atcaaagtgc tgggctccgg tgcgttcggc acggtgtata aggtaaggtc 160020
cctggcacag gcctctgggc tgggccgcag ggcctctcat ggtctggtgg ggagcccaga 160080
gtccttgcaa gctgtatatt tccatcatct actttactct ttgtttcact gagtgtttgg 160140
gaaactccag tgtttttccc aagttattga gaggaaatct tttataacca cagtaatcag 160200
tggtcctgtg agaccaattc acagaccaaa ggcattttta tgaaaggggc cattgacctt 160260
gccatggggt gcagcacagg gcgggaggag ggccgcctct caccgcacgg catcagaatg 160320
cagcccagct gaaatgggct catcttcgtt tgcttcttct agatcctctt tgcatgaaat 160380
ctgatttcag ttaggcctag acgcagcatc attaaattct ggatgaaatg atccacacgg 160440
actttataac aggctttaca agcttgagat tcttttatct aaataatcag tgtgattcgt 160500
ggagcccaac agctgcaggg ctgcgggggc gtcacagccc ccagcaatat cagccttagg 160560
tgcggctcca cagccccagt gtccctcacc ttcggggtgc atcgctggta acatccaccc 160620
agatcactgg gcagcatgtg gcaccatctc acaattgcca gttaacgtct tccttctctc 160680
tctgtcatag ggactctgga tcccagaagg tgagaaagtt aaaattcccg tcgctatcaa 160740
ggaattaaga gaagcaacat ctccgaaagc caacaaggaa atcctcgatg tgagtttctg 160800
ctttgctgtg tgggggtcca tggctctgaa cctcaggccc accttttctc atgtctggca 160860
gctgctctgc tctagaccct gctcatctcc acatcctaaa tgttcacttt ctatgtcttt 160920
ccctttctag ctctagtggg tataactccc tccccttaga gacagcactg gcctctccca 160980
tgctggtatc caccccaaaa ggctggaaac aggcaattac tggcatctac ccagcactag 161040
tttcttgaca cgcatgatga gtgagtgctc ttggtgagcc tggagcatgg gtattgtttt 161100
tggtattttt tggatgaaga aatggaggca taaagaaatt ggctgaccct tatatggctg 161160
ggatagggtt taagcccctt gttatttctg actctgaaac ttgcattcaa ttcactccac 161220
caagttatct catctttgaa atggcttttt ttaaaggtgc ctagaatatg atggcgtgca 161280
gtctataaac tgttgcccac cttctgtact ttctctcaga ataattcaca ttcttctcca 161340
gtgtctgttg attgttactt tgtggaataa gttcttggaa aattccacaa gattattgtt 161400
atcttcttac taccaattct attgaacttt ctccaccttc tctgggcctt ccccagccag 161460
tggtgggaag atgctggctg gagtctgaca gagcctcttc tacactggcc tgggcttgct 161520
gtgagttggt ggaaaccttt gctcttgtcc caacacagag caagtgaaag aggaggtcaa 161580
ggggctcagg cagcggacta gggaagcaga atcgaggaaa aggaaaaatg gctgacttat 161640
tacctcaaaa ctctagagaa tttagttgat cttacagcca agaaggacaa aagccagaga 161700
gtaatatcct ccgcctcatg tctaacccac agaatacata gcaagtaaag agaacatggg 161760
cctttataaa aatgtcttaa gatacaattt tttaattgga ggaaatctac agtttaattt 161820
tctctgggca gcttttcttc cttttattat agtaggggaa atcccatgtt gatatacttc 161880
taaatgaaag atgatgaatt gatataatac aataaaaaat ctgtaaaatt gatgatatac 161940
ttatcaagaa aaattagctt tcattttaac ggtttacaaa ttgagtcaag tcctagtaac 162000
aaaatgttaa gtctattaac ataaccacaa gaaatacagg aagacgggca atctgtgaag 162060
cctttcactt acaatctctg gcccctcacc tgtgctgtgt aggaaaatct ttgtgcacaa 162120
tttgcttcct taattcattt tttattcatt caacacattc taataaatta tacaaaatca 162180
tgttgaaatg tgaatttcag tggtatttat aaatgcagtg tgaggagggt ttggatgtat 162240
tctaagacaa tagttgtgct ttgggaagga agcagtgttc actgaaaagt gcccccagga 162300
ccttttaatt ggaggaaata tgcttctgtg gagttggaaa tggggtagaa gatagataag 162360
gtcaaggctt aaaagttaag tgcacccaac atctgaagcg tccatgggcc tggcatggtg 162420
gctttcgcct gtaatcccag cactttggga ggctgaggca ggaggatccc ttgagcttag 162480
gagtttgaga ccagcctggg caacatactg agacccagtc tctacaaaaa ataaaaaatt 162540
agctgggtgt ggtgtctcat gcctgtagtc ccagccactc aggagatggg aagatggctt 162600
gagtccagga gatctaggct gcagtgagct aaaatctcac cactgcactc cagcctgggt 162660
gacaaagcaa gaccctgctc aaaaaaatag ttagatataa atattaatat agatacctat 162720
atatatctga atatagatat ctatatatac tctgtatata gttatttaga tatataaata 162780
tatatgatat atatttagag agatatatat ttagagagat atatatttag agatttatat 162840
atattttata tatatttaga gatatatatc tctaaatata tatctctctc taaatatata 162900
tatatctctc tctaaatata tatatatccc taaatatatt aaataaataa aagaaataaa 162960
agaaagctca gtttggcctc ctgcttgtcc tgtctcctca tcccctcttc cccctccatc 163020
attttatttc cttgccccat gtttcttcac tgcggccatg tcccccctcc tctccaatga 163080
tggatgtcat gtctgctgca gtcagagggc gacaagcctg gagtgttccc tgaagcctgt 163140
ggtttgtggt ttgtcctgca gctcaggctg cccaggcctc accagcaatc ctggcgggca 163200
gggcaccaca ctgggatgga gagggggaag ctggaggagg cactttctgg taaagaaagc 163260
aaaagccagc agtgcccagg ccaatttcaa cagggagtta aatagcacct taatcctgtg 163320
gcaggacagc tcatggggcc atgtgtgctc ttagaaagac tcacatgcac gcatgcacgg 163380
cagcaatgac tccatactca cgttcccctg cagacaccag gcccccacag ccggcacaca 163440
cactgcagcc ccagttccat gttgctagca gtggcttagt gaatgagtaa agttcttaaa 163500
atgcagggga cacctgccct tcattcataa ggctggacgt acacctctcc ttaaggagtt 163560
caagagctag tggaatccca attcatacgg tagagccatt cacagatgag agagacaagc 163620
cagaaggaag gaaccaaaag tcatgtcagc agttaggaca aaataacagg ctttcaaggt 163680
cacaaagcct cagggacact cctgcggtgg gactgggcta ggagccatgg gggctccaac 163740
tgtgcgctct gcctgccagc ctgtgggtgc tggggctcca cgaagattgt tgtggaatac 163800
caagcatgct tgctgtaggt cacggtgcac gtttactact tccaagacaa acagccgaga 163860
acaaagctcg ctttagcttc tgcgtacacc gaacgggaca cacgactgaa cagcgttccc 163920
attgtgcctg ctgggtgggg aggaagtgat ggcccagtgg gtctatcaga tgttagtagg 163980
atggggcctg gcggggctcc aggctctgtg tggccgacac ccacgccccc cgctctgctc 164040
cccattccca gccccaggtc agccctgcga ggccctgcag cagatgggct gctcaaactg 164100
ctctggtttg cagatttttc ttccctctca aatgaataca atatgttttc aagtctcaac 164160
cagatcttga gaaaatagga agagccagag ggtttctttg gtgttatggt tgtacagctt 164220
cccagactcc gggggagaga tgtgatttgt gctttctggc aatcccatgg cgtattaaat 164280
tttcataggc tttccagttt aaatttaggg taggcaatgg aagggaacgc aaaacagatt 164340
tctaggtgta ctgtgtgtgt gtctcccacg tctaaagtct gttaactgga gcacccaaca 164400
ggccccacag gctgccttca cacagaggac ctggggcgcc tccgacccat tggggtgagc 164460
agtgggccat ggagggagcc agggtcagga gacctggttg tgggcctgac ctgaccctgc 164520
tcagggtggc ctcaggtggg ccgttcacct cgtcagcctc agcttaccct ctgactacag 164580
tgacctcaga caaaatacgc ttcctggccc tgtccagttc tgacttttta taaacaagca 164640
cttatccaag ttaaagggat attttcaata tctactgagt ccacagatat taaatatctc 164700
ctctcttctt taaaattgtg gcattatctt tagaatataa aaggaaaata acacacactc 164760
tccttgaaaa tagagagcct aaacactctg caggaaatat ttaaagctat agtttttgtt 164820
tgtttgtctt gaatgcaagt ggcctggact ttgacttgct ttgagtcttt gaccttcatg 164880
acttcagtac agttcaaccc tgacagtttt gaagtaggta tgtgcctaga tctgccctag 164940
tccctgctgg aatgttgaag aagcaaaggt ccaggccctc agagcacttg ccacgtactt 165000
gccaacagat acggggcgga gacttgagtc aacgtaagag caagtgtgtg ccgggtgatc 165060
cgacactgca gagcgccagc tagaccctaa gcgtgtgcta ggggctgacc aagccgttct 165120
ttcctcaaaa acttggtggg gagggtattt ttaaaatcac acaaatattt aagtacagat 165180
tatgatgact gcctcaaagc agtggctctt cagcttcatc aagcttcaga gtccagaggg 165240
tttgttcata tggaaggcta ggcctgtctc ctgcatttca ccctcttggc ctgggggcgg 165300
gacccaagaa tgtgtggctc taaaaggttc ccaggcaatg ctgaggctgc tttctgaagg 165360
aaaaactgca agataccagg agagtttcat ttagattgaa gagtcgagga aggctcctct 165420
gagaaagagt ctgctaagga aggaggaggt gggttctggg gacagaggtt ctcccgtggg 165480
taagggtgga gggaagctct cctggggaga aggtgggcag gaggaccaga ggctggaggg 165540
aggagggcag tcagcctcgg ggcttcccag gaacagggac ggccagggca gggtttaggg 165600
caaggaaagc gtgtgagcat atttgtattt tagtaaatat ttacagtttg ccctccatgt 165660
ctgcagtttc atatccatgg attcaatcaa ccacaatgaa aaacgttggg gaaaaaaatt 165720
gcatcggtac tgaacatata cggacttttt ttcttgtcat tattccctaa acaatacagc 165780
ataacaatta ttcacatagc atttgcactg tattaggtac tataggtaat caggagatgc 165840
tgtagatggg aggatgtctg taggttacac acaaatgctg tgccacttta tatcaggggc 165900
ttgagcatcc tcacattttg atatttaagg gaggtcctgg aaccaattcc ccagatactg 165960
agggtccact gtctgtgtcc cctcgcccca ccttgccttt gtctcctgtc tcctatctcc 166020
accctgcctc ccgccagcct gttgctcctg acctgcccgg gcaccctgga gcagcaccct 166080
atctcagagc ctggctcagt gtgttcactt ctgcagagaa actaacttgc ccaagtccac 166140
actcaaaaca taggcattgc tgagatgtga aaagcagctg tggatgcttt ctgctacagt 166200
ctgtgtgttc ttttccatat ctgaataaaa ggtcaccacc atttgtattt taaagagaaa 166260
gagaatttat gggtggaaat tggggattcc ctcattctca gtcagacaga aaagagggcc 166320
ccattgtgtg cctgattgca aataaattta gcttcctcag cccaagaata gcagaagggt 166380
taaaataaag tctgtattta tggctctgtc aaaggaaggc ccctgccttg gcagccagcc 166440
ggaattagca gggcagcaga tgcctgactc agtgcagcat ggatttccca tagggagcct 166500
gggggcacag cacagagaga ccacttctct ttagaaatgg gtcccgggca gccaggcagc 166560
ctttagtcac tgtagattga atgctctgtc catttcaaaa cctgggactg gtctattgaa 166620
agagcttatc cagctactct ttgcagaggt gctgtgggca gggtccccag cccaaatgcc 166680
cacccatttc ccagagcaca gtcagggcca agcctggcct gtggggaagg gaggcctttc 166740
tccctgctgg ctcggtgctc cccggatgcc ttctccatcg cttgtcctct gcagcaccca 166800
cagccagcgt tcctgatgtg cagggtcagt cattacccag ggtgttccgg accccacaca 166860
gattcctaca ggccctcatg atattttaaa acacagcatc ctcaaccttg aggcggaggt 166920
cttcataaca aagatactat cagttcccaa actcagagat caggtgactc cgactcctcc 166980
tttatccaat gtgctcctca tggccactgt tgcctgggcc tctctgtcat ggggaatccc 167040
cagatgcacc caggaggggc cctctcccac tgcatctgtc acttcacagc cctgcgtaaa 167100
cgtccctgtg ctaggtcttt tgcaggcaca gcttttcctc catgagtacg tattttgaaa 167160
ctcaagatcg cattcatgcg tcttcacctg gaaggggtcc atgtgcccct ccttctggcc 167220
accatgcgaa gccacactga cgtgcctctc cctccctcca ggaagcctac gtgatggcca 167280
gcgtggacaa cccccacgtg tgccgcctgc tgggcatctg cctcacctcc accgtgcagc 167340
tcatcacgca gctcatgccc ttcggctgcc tcctggacta tgtccgggaa cacaaagaca 167400
atattggctc ccagtacctg ctcaactggt gtgtgcagat cgcaaaggta atcagggaag 167460
ggagatacgg ggaggggaga taaggagcca ggatcctcac atgcggtctg cgctcctggg 167520
atagcaagag tttgccatgg ggatatgtgt gtgcgtgcat gcagcacaca cacattcctt 167580
tattttggat tcaatcaagt tgatcttctt gtgcacaaat cagtgcctgt cccatctgca 167640
tgtggaaact ctcatcaatc agctaccttt gaagaatttt ctctttattg agtgctcagt 167700
gtggtctgat gtctctgttc ttatttctct ggaattcttt gtgaatactg tggtgatttg 167760
tagtggagaa ggaatattgc ttcccccatt caggacttga taacaaggta agcaagccag 167820
gccaaggcca ggaggaccca ggtgatagtg gtggagtgga gcaggtgcct tgcaggaggc 167880
ccagtgagga ggtgcaagga gctgacagag ggcgcagctg ctgctgctat gtggctgggg 167940
ccttggctaa gtgtccccct ttccacaggc tcgctccaga gccagggcgg ggctgagaga 168000
gcagagtggt caggtagccc tgcctgggtg ctggagacag gcacagaaca acaagccagg 168060
tatttcacag ctggtgcgga cccagaaaga cttctgcttt tgccccaaac ccctcccatc 168120
tccatcccag tcttgcatca gttatttgca ctcaacttgc taagtcctat ttttttctaa 168180
caatgggtat acatttcatc ccattgactt taaaggattt gcaggcaggc cctgtctctg 168240
agaatacgcc gttgcccgtc atctctctcc gacagcaggg cagggggtcc agagatgtgc 168300
cagggaccag agggagggag cagacaccca cccggcctgg gcaggtcctc ctcattgctt 168360
gcatccgcct ggttagcagt ggcagtcagt cctgccgagt cattcgtgag gcgctcaccc 168420
aactccaggc agatgtaaaa ggtgacctac aagaagacaa acaaaaacat ctggagcgct 168480
cttatgccag catctgccct tgacaccacc aggcaggctg ttgctgggag ccgtggtgct 168540
tgggtaagct ccttcccatg gcagagctcc tgggacgcat tgtagaagca gggaccacct 168600
cccaggataa ccagatagca gcacaccctg cacagcccct tttactccag catcatcggg 168660
cattgatatc tcagctgcag ccacaggcgg cccccagcac cccaggaagt ggggagcgct 168720
catgcttctc tgagcacaaa aatcactgaa tatttttgcc attctcatgg tcataacccg 168780
ggccacagag tagaacactc ctatcactgt tgttagacag tggtcctggg agagggtctt 168840
gtgtgcctcg gatgccaggg cctcttttta ttgggaggtg cttgttattt ctgtgtgtgg 168900
ctgcatttgt ttcccaagac tgccacaaca aatcatcacc aacttggtag ctcaacatag 168960
cacagcttta ttccctcctg gctctggagg ccaggtgtct aaaaggccat gctcccacaa 169020
tggttctgag gaggatcctt cctgcctctc tggcttctgg tggctccagc atccctgggc 169080
tgtggctgca cctccccatg tcaacctccg tcttcacaag gccttttcct gtgtctctgc 169140
aaccacaggc ccctctcctt tctcttaata aagataccag tcattgagtt tgaaaattgc 169200
taagagagtc tgttgtaaat cttcttagca caaaaaaaaa tgacagatat gtgaagtggt 169260
agatatatta attagtttga tttgatcact ccgctatgtg tataaatgtc aaaacaaaca 169320
ttgcactcca taaatatata tattaaaaaa gatcccagtc attgcattta ggacccaccc 169380
taaatccagg atgatttcat ttcaagactt ttaactagat ttgcaaaacc ccatttccaa 169440
ataaggtcac attctgcagt tttgggtaga cgtgaaatgt ggagacactg tgcaacccac 169500
tgtcttgggg agggggtggt cagcctgggg cagatgttgc tgggtgtgga gctacatcca 169560
ctcatgccct gacctggaac ccagacctgc ttccccagct ctcctcctgg ttatctgaag 169620
cagggaatgg agagcactgc cctccttgcc caggcagtct ctatcacctg gttttagttt 169680
cttcttagca catattgccc cagaatatct ggttggttta tggcttactt gagtttgtgc 169740
ctacctgtcc caaccgggag gtgagccctg gctattcccc aaacccggcc ctgcatgtgg 169800
gagctgccct tcctccgttc atcagagggg gccaacagtc cacagctgtt cttaatcatc 169860
tcccagtaac ccccagctcc acaaaggtga ctccttacat ggtggagagg tggtcgggcc 169920
atccgtgtga aatgtgtatg tgaccgtttt ccttaagggg cacgtagtct tggcaggttt 169980
cgctcaatat aggatgagct caggactcca gtggactgtg gattcagatc tggattctgg 170040
cgcattcgcc gtgtgaacgg gggcacgttg ctggcctgtc tgcgcctcgt ctcccgactg 170100
tggagtgtgt tctgcccctt gtctttctgg gaggtaggga gggcagtgag ccccttcgca 170160
tcgcccacca caggcccagc acatggctga tccccactga gtgttctttt cctcctttga 170220
tcccctttgg ctgacctagg ttggagcagc cactaaaata tacccagaaa catcttccta 170280
atctacatct gtgccaaccc tcattccctg gcgcagcatg accatcacat gcccgccatt 170340
gttcctgatc tctgctgctc atgacctgct ctccagcgct ccttctcatg ctcacattcc 170400
agttggcctg acctagataa gtggaggttt atttgacccc aaaaattagc cttctacaaa 170460
cgaatataat agtgtccatt acagagaata aacttagtgc gtgtcccatt taagcagaag 170520
ttactgaaag cctgagttta agtttccagg gcctgaaagt tttccatgac agttttctgc 170580
ataatattac ctacaatttc aatctgttat ttaaagccat tcttgtgttt gttgtacttt 170640
gattagcttt attttgattt gaagtccttt tacattacgg gcagttaacg ctttgtctct 170700
gttagatttg ctttttagtt cacaagagaa acctcattcc tctgtatttg aatagttgca 170760
atgatggaac agctgtccct ggagggaaat gaaaacagtg attccccaaa ttgtgacaat 170820
agaaatttgc tcttgggtta cttacaatgt atctgagtat taaaaaattt tctttttaaa 170880
cgtttgaagt aaaactaccc agaaacactt agtggctgac cagaaactaa actcctggca 170940
tcctcaaaat gggatttatt ggcttataaa tgtcctgtgt tgactcacaa aggcacaaac 171000
tatctaggta agttttcttc taaatgttga tgggagagct ggccactgtt atgcaagttt 171060
cattgtcctg actaaactgc caaagagatt acataaaatt atatcaacta gacaaaagga 171120
aaaaggaaaa aaaacagagg tgtcttggga ggaatccata tgagaccagt agaccatgag 171180
agagacatcc cttgccatct acaaggaaaa tggattttgt tctccatatg caaaaccatc 171240
tcaggagctt gcggagacac cacttgctta ctagccagaa agagcaggtg cctcctaaat 171300
tccccacaca ggagctcaca gtggctttca tgcactggga ttaagttaga cttaagaaag 171360
cctgtctact cttcctggga tttacaagcc agctagtaaa tcccagaata aatcacacgg 171420
cacagtcatc caaagatccc gtcatccgtg ccgtttggaa agccctgctc ctgtgccacc 171480
ctctccccgt ggagcctccc atgcccagga ctgcagagtc ctgccattca gactgcaact 171540
catctcacat tcttccaaac tatttggaca acagagcttt ctcatcacct aatgcagatt 171600
acagtctcac agaattgagt gttcaggcag acactgatgt ggttctgtag tacagcaaac 171660
aatatcagtt tacagtcctg aggccaggcc tggtgaacaa cgcacggtag cggtggggca 171720
gggttctcag aatgaaactg gcttacacat ggcactctct gaccacaact gtataagcac 171780
caaactacac ttagttccat ctatgaggta aaatttaatg cagatgaaca tcaaagaaaa 171840
cgtcaaaggc tcctttttac aagtacgtgg gctacttaat ttggtccaag tccattttaa 171900
aaagccctag gtgctttcac ggctctgcta ctgacaagaa gccccagtgc ctgtgagctg 171960
ctaatgggag ggagaggaag atgagctgag tgggccgggc tatcccgtcc acaccgggag 172020
acagggaagg agactccaag ctggtggtgc cagcacattc caggccactc aggcctattc 172080
ctaggtgcca ggtcacgaaa accacgctga cagatcgtgc tgtgtgcgtg tcatagcaca 172140
caagcaggac tgtgagagag tgaaagtgac actgggtgga gcactgagga agggccacag 172200
tgtgttggtg gagataggct gtcatggaga agagaccctg gcttgctcta cattgcttcc 172260
aatgcaactg caaggcaggt cccagagggc tccggccttc gtcatccagg tttgctccct 172320
cccctcatgg ctttcccatc ctcagatgag gactcggcag agcctacccc tgctgactaa 172380
ctgtggcccc agggtggtga ctcagccctg cacctcctga tcccgtctgc actgggccag 172440
agaggatgac ttacccagca cgttcacatc acacagcttt gtggattcct aggtccaagg 172500
accagagatt tcagttatgt gagttatttt ttttatttgt tcttgcgtat tccacaaagg 172560
gtcgcagcta aacttaacct aatgatcact ttagtatatc actaaaaaga caaagctcac 172620
agtgctgttg aagcacattc atcatcttta gacattttga ctagttattt cttaagcatt 172680
tacctgctag tgttaagcat cacatgaaat acatatagaa gtaagacaaa atttcttatc 172740
tccccaagtt tgccaacaaa tacagagcag gaagggaagc aggtcagagc aggaggcgca 172800
gctatagtga ggccaccatg caaggcacag ggagggtgag ctccaagttt gaatggaatg 172860
ggtctgtcag ccaagccccc tggctctggg aagatagcag tgaacaagcc agatggcccc 172920
tcaccctcca gagccgtgag tcctgcagac caaacagcgt gacaggtcct ttccctgtcc 172980
aggaggcctc tgtgggtgag agttggctgc ggacagggcg tgaaggcact tgagggtggg 173040
gaagtgactc tgactgggag atgctgagga cagggaggaa accaccagat aagggacact 173100
ggggaggagg ggtggacccc tcagggccaa gcacatggag cctcatcaca aaggcaagat 173160
ggtggccaaa ttcaaggtcg ctgcaaaagg aatggagaag agagaataga tttggcattt 173220
ggaggaaatg gtgacaatca tgagcaccta cccgggactc tccatgggtg ctatctctac 173280
ataaactcat tccaccctct gattaatcca ttctacatat ggggaaacaa aggcatgcgg 173340
tgtttacgtc acttgccaag atctcaggat ttgatccagg tggcctggtt ccatggtgca 173400
gcctctcagc ctgcatggat gccccagctc agagcatgac tctcaggaca ggggtcccag 173460
cagccctccc tccctgagca gcagggtgcc cgtgctgcac cacttctgtc taggaatagg 173520
acattctgac actttcctgc ctcttccgag gtctagcact tactctatgc ctgcctggga 173580
aggtggcaag ctggcctgag gaacagactc ttccattttt tagggagctc aaggccacag 173640
atgctctgag atctggagtc cagagacagg agcggaggct tctcctggtg accactctgc 173700
ttaaaaactt catcagatcc gtagtttcag agcccccctg aaccccatcc cttacctcta 173760
ccagttgcag gtgggtctct ggggtggggc tgccctcccc accagcaccc caagggctaa 173820
aaggttgagg ggagaacacc atcatttgta cagggggatc ctggaagatg aggcctgaga 173880
aagccctgcg gggcccctca ccttctccct agctgtggcc aagagtgtct ggccttgcct 173940
gcctcaggac cagcccaaag tggaggtgag aggtgagccc cagcccccag gggaagggtg 174000
atggtggtct tggtctcagc atggttctgg tagaggtggg ttattttgaa gatgatgaac 174060
cttaagcctc tttctgatct tgctttaaat aaatacttct gaacaacagc aacaacagaa 174120
tagtgttgat aggaaagccc tccactccac cagaaccacg cggccttctc gtcctcccct 174180
cctccacttc cttcctaagt cactgctcca tgagctcttc cacaggagat ttacaaaata 174240
gaacacaaac aatccagttc ccgcctctca ctctgaactc ctcccaagac tcgtggggtg 174300
cggcagcccc tgggaacacc cagcccttca aggtcaaaca cagcccccgc ccctcactct 174360
ggggtaccct gccagaataa gccccgacag ccatgtggag cagagccttc ttttttgtaa 174420
gtggaagttc caggctggct tttcaaatcc ccttttaacc tcagtgctgt atttcaaaat 174480
tcattccagt tttcctgtag taattaacaa aaataaatat tttaatttca attaaagtga 174540
gggtctcgga gaagaagcag gaactgagtt tcctgagagg ccccgctgag gctttgttga 174600
tatttcttcc tgcgacctct gctcggaccc tgggagctca caggccgtat cgcagctctt 174660
atctttgggg accagttaaa gcataactgc gccaggcaca gagttgtcct ttcaaatgtg 174720
ccggcagtgg gacggagacc catgcgtcaa gtctcctcta agttcacatg ggattctctc 174780
cttgtcccaa agctgtctct gacttaaaac cctccaactg attacctgaa ttccagaata 174840
tgtcctgtgc tctctgccct ttcccacgcc tttggtgaag accggtgttc tgaggaaaca 174900
gacactgtgt agaaatggct caggtccttt aaagccctgg tgtgaggagt ggggaagggc 174960
tgggccagag gtcagctgga tttgttagat tgacagagtg acgcggactt ccccagaggc 175020
acgggaccaa ggtgcatgct cacgctgtct catgctctca cacataatgt gtgtgtgtgt 175080
gtgtgtgtat atatatatac acatatacat atatatatat acacacatat gcatatatat 175140
aaaaccccaa gcagcctctg gcttagcagg tgcatttccc agcagggcaa ttaaagccat 175200
ggtcccagta gtggtcttgg ggtctcaggg tatttggtct gtgcagccac atgcttcagt 175260
ctctggaccc caggtcatct aacgaggtgg tcgtgtgggg actgggatag aaaaggtgtc 175320
tgcacggacg tgtgtgaaag ggctggcaca tcgccagtgc tcagcactgt cagctgctat 175380
caccagtcat tcaatcattc attcattcag ttgttcattc ttcaacaggc cgttttaaaa 175440
atgtgcccag tataccaaaa tctccgctaa gcatttaaag aggcagaatg aaagttagca 175500
gtggtggtga aacgaagctg ggaatgtgct ctgagggcct ccttgtgggc ttaatgaata 175560
tgtagaaacc acgcatttta aatagagagg gagaaaggga gaggttcctg gtcctctgca 175620
tggggacttg tgtgtggctc tttactgtag gcctgtgcca ctcctgctca acagctacca 175680
cagaggacgc cttcaacaaa tgtgaagaac gaacaaaagg tacaaatgtg aagaacgaac 175740
agggtagaaa gaaaggagaa agcaagggtg agggtgagaa atcaagggac agagaagaga 175800
gaagaggaga tagcctggga gttcacacag ccaagaaggt agacactcag ttgaaccagc 175860
aagaggctga gcctaactct ccctttcgaa tgggcaggag ttcatgatat ttaataaaca 175920
gaggccttgc tctgtaagag acagggtacc aggcagagag caagtcagca tcgcaggagt 175980
caaacgaggc agacagcggg ggcagggagc ttgcctctga aggagaccca ggctgccaga 176040
gtagcaggga gtctgggcca gtcctctttt gggaagcgct tcctcggctt ctgccccccc 176100
tctcctctcc ctttccaccc accatcctga cataatactt cctaatctgg aagtgttgtc 176160
cagagaagaa cctgctcatt tcctcttaag taggcaggga agcactaacg tccagcagca 176220
tcggaaaccc gtaggagcgc tctcggcagt gcagggtgag gggacagtcc atgtagtcat 176280
gagacgtggg tgtcaggcaa gcgtctcttt tccaaaagag aaaaacatta aaggcctcac 176340
aaacggcgcc caaagactaa ttctgcatag catctttgcg agaccctagg ttcttatgat 176400
gactggtttt gcctgagaaa gaaaaaattt taattttgct ctgacatgcc aattcaacaa 176460
atcattttca cataatattc atgcaaaaaa aaaacaattt gccagaaaac ttgggaatcc 176520
atccacatct acagcttttc cctgcagtca cactacagtg ggatccctcc atacaggagc 176580
ggcagagtgg agcaggctag agatgcctgt ttgtttctgt ttgctgcacc gcagcaagca 176640
tttctgtcgt gcccactctg tactagaaag tacatgaaca tcagccataa agggaactag 176700
aaaggtggcc caccctcttg gtggagagag aagagagtgt ggtagaaaca ataataagaa 176760
gtctgcagaa cttgacccct cccagcctct cccacctgcc agcctggccc ttgcagagag 176820
atgcaggctg ccattcttag gccaaagcct gggacagttg ggctcagcaa ggtaggcatc 176880
cgtcaagcaa ggaggagcag gggtcagcag tgaccccagc agccagcagg gagaaaggtg 176940
catgtgacaa ggacaccaga ggccgtgggt caggatcagc cagggtcagg gtagcatttc 177000
taggaattca ctctgttggg cgctgtgctg gctgcttctc acatattatt cctttcttac 177060
tctcagagca gagatttcaa ttgcagcgag attgtggagg cagccaggga ggtggggagg 177120
gtggtgtctt ctaaaagcat tttcagtatc catgtggttt cagtaataat aataataata 177180
aaccagtgaa aagtaaaaca ggacaaaaat cttcataggc agtgaaccat atcagagagt 177240
ccaagaaagc acaatgagag tgtggcttaa aaaccctgaa cgacattcct ttgcaccagc 177300
ttggtgagga gggcatggtc cccgccaccc cccaccccca ctttgcagat aaaccacatg 177360
caggaaggtc agcctggcaa gtccagtaag ttcaagccca ggtctcaact gggcagcaga 177420
gctcctgctc ttctttgtcc tcatatacga gcacctctgg acttaaaact tgaggaactg 177480
gatggagaaa agttaatggt cagcagcggg ttacatcttc tttcatgcgc ctttccattc 177540
tttggatcag tagtcactaa cgttcgccag ccataagtcc tcgacgtgga gaggctcaga 177600
gcctggcatg aacatgaccc tgaattcgga tgcagagctt cttcccatga tgatctgtcc 177660
ctcacagcag ggtcttctct gtttcagggc atgaactact tggaggaccg tcgcttggtg 177720
caccgcgacc tggcagccag gaacgtactg gtgaaaacac cgcagcatgt caagatcaca 177780
gattttgggc tggccaaact gctgggtgcg gaagagaaag aataccatgc agaaggaggc 177840
aaagtaagga ggtggcttta ggtcagccag cattttcctg acaccaggga ccaggctgcc 177900
ttcccactag ctgtattgtt taacacatgc aggggaggat gctctccaga cattctgggt 177960
gagctcgcag cagctgctgc tggcagctgg gtccagccag ggtctcctgg tagtgtgagc 178020
cagagctgct ttgggaacag tacttgctgg gacagtgaat gaggatgtta tccccaggtg 178080
atcattagca aatgttaggt ttcagtctct ccctgcagga tatataagtc cccttcaata 178140
gcgcaattgg gaaaggtcac agctgccttg gtggtccact gctgtcaagg acacctaagg 178200
aacaggaaag gccccatgcg gacccgagct cccagggctg tctgtggctc gtggctggga 178260
caggcagcaa tggagtcctt ctctcccttc actggctcgg tttctcttag ggaccctcac 178320
agcactaagg ggtgcgcgtc ccctgtcagg ccctcgaatg ccctcccaca gccaggcccc 178380
tctgaggttt cactctggcc tgcttggctc ctagcagcca ccaacccatg atgctgggcc 178440
ctgaaaacac acgcagacct ggatgagtga ggccactggg cacaaccagg gctcccagct 178500
caccagagca gcctgggaca cagagggtgc tcagaaacct accagagcag ccctgaactc 178560
cgtcagactg aaatcccctg ttgccgggag gaggcgccgg gcctggggga cgggtcctgg 178620
ggtgatctgg ctcgtctgtg tgtgtcactc gtaattaggt ccagagtgag ttaacttttt 178680
ccaacagagg gaaactaata gttgtctcac tgcctcatct ctcaccatcc caaggtgcct 178740
atcaagtgga tggcattgga atcaatttta cacagaatct atacccacca gagtgatgtc 178800
tggagctacg gtgagtcata atcctgatgc taatgagttt gtactgaggc caagctggct 178860
tttattgtta gttaatttac attatatcct ctgacatgca agtattttct ttcgagataa 178920
tgactaatga taatgtaatc attgctgtct atctattgta ctgagaaaac acggcagagg 178980
aaatcgagtc cagctgccgt ccaaaagtca ctggagattg caatgagctc gtctggcagg 179040
gtggggggta tgggagggaa agagcttagg aaacggctct ccctgcaaag tccaaccaaa 179100
ctttaacgtt aaccaaacca ttaatgttgc catgaatttg aagtgaacca gagggaggtg 179160
gcagaagaag cttaatgggg aatagttccg gtagagaaat gaggcttaag atgaactacc 179220
ctggccctta tgtgtcagag agaacggctt gacaaacaca cactgaggat gtctgcaggg 179280
ataaaagaag aaagggagat gacccttgct tctcgctctc gggaggacca tctggtccgg 179340
ccctggggat tctctgtttc ctcttctgaa tcccagtgtt gcccagcact ggcctgtacc 179400
catcctcacg agggccgctc tcctcacccg gccctaggtc cctgccctgt cctgagccta 179460
caggggcctc ccatgttgag aaagtgttgc tgacacattg tctctgaccg ctgtgccagg 179520
cattttctgc tgaattaccg cacttggtcc ttgaatttca cccagcaact tactgaaagg 179580
ctggaaccca tgaacctacc ccttcactga ggaaaataag ttaccccagc catctacagc 179640
gacaggagca agggaggagt cgcctcacct ctctagaaat gtgtatttga ggagaacact 179700
attgaaatga atttccaaga ataatctagt cagtattaca aaagcaaaat tatttgggat 179760
atcgtccttt tttacttagt attttttctt tttcctatag cattattaac tttctgattt 179820
tccaaataca tacacatttt taaatttcct gagtctttat ctcttctgtt aaaatgtaag 179880
atttatgata caaaggcaga gatttgtgtc catgaataag tgaagtttgg tgtgcacctg 179940
tgagctgagc cacctcaatt aatggaacag ataaggaaat aaaggtctgc tgatgcattg 180000
ttatttacag ccattttcag aatgtatctc ctctccacga gggaactgca gggtcctgcc 180060
ccaagccatt tattttgtcc tcaagcagcc cgcccctccc actccaggca cagcccggtc 180120
tcctgctggt ctcccctctt cccacttgct ccccctcatc tatgctccag acagaggcca 180180
catatatttt ttaacttttt tttttttttt tttgagacag agtcttgccc tgtcacccag 180240
gctggagtgc agtggtgcag tctcggctca ctgcaacctc cacctcccgg gttcaagtga 180300
ttctcctgcc tcagcctcct gagtagctgg gattacaggc gcacaccacc atgcccagct 180360
aattttttgt atctctagtt gagacagggt ttcactatgt tggccaggct ggtctcgaac 180420
tcctgacctc atgatctgcc cgcctcggcc tcccaaagtg catatttttt aactttatca 180480
gacttttcat tctctgctca acatctttct ttggtcctcc aggtatgttc agataaaacc 180540
tgagcacctg gccatgactg atgggttgct gggccatctg gccctggcaa ctctcccgtc 180600
caccaggtcc ccctcccgtc acgctccagg catagcctgt gtgtgccagc gcaatgccca 180660
cactccatgc acaagtggaa gccctctcaa agtcagtggc ttagtgcctt gatgtggtca 180720
cacccattct caggaagtcc gttcccactg aaaacattgt gtgttttcaa catcattgag 180780
gctgccacgg cagattataa tcactggcct aggcagccca ctggaactac cagaccatga 180840
gcctgaattt tttgtttaaa aatcatatcc tgttttctct actctctagt ctctagtcaa 180900
ggtgaattat tcaatttaat aaattagggg cctagtgtgt tgtaccaagg agctaaaaag 180960
agagaactcg caacaccttc cagcccattc tccacctaac actggctata ctggctctcc 181020
tctctctcgc tgtttgttcc aaaatctaat aacctgtctt cccactagaa ttcatcatac 181080
atgtttaaaa acctagttaa atagtagtta aactgactgc atagatctgg aaatgagaca 181140
gtctttcttt tacaaatcca tatagactat gagttggggg caggggatga cacaagaatc 181200
tattttcttg cccccaaacc attgctttcc ttccaatgtt aagcttgtat tctgtgtatt 181260
aattcaggtg gttccgtttg ggaatggcct ctgttaccca gagatgggag ggccatcaga 181320
actcggggtt gtctgaaaaa acactggttc taaaattatc actgctttca cttgttttta 181380
accatcatag ttgtttgatt ttgaaggaaa aacatgaggg tttttattct atgcttgtta 181440
tatctatatt gtggtttcgt attttttaga ttttagtacc tgacattttt ttaactttta 181500
ttttaggttc aggggtacat gtgcaggttt gttatatagg taaatttgtg tcatgggggt 181560
ttgttacaca gattatttta tcacccaggg attaagccta gtacccatta gttatttttc 181620
ctgatcctct ccctcctccc atcctccacc gtcctataga ccccagtgtg tgttgttccc 181680
ctctaagtgt ccatgtgttc tcatcattta gctcccactt ataagtaaga acatgcggta 181740
tttgattttc tgttcctgca ttagtttgct agggatgatg gcctctagct ccatccatgt 181800
tcttgcaaag tacatgatct cattctcttt tgtggctgcc tagtgttcca tggtgtatat 181860
gtaccacatt ttctttatcc agtctgtcat tgatgggcat ttaggttgat tccatgtctt 181920
tgctattgta aatagtgctg cagtgaaaat acgcatgcat atgtctttat ggtagaatga 181980
tttatattcc tttgagtaat gggattgccg ggtcaaatgg tagttctgtt tttagctatc 182040
tgagaaattg ccacactctt ttccacaata attgaactaa tttacattcc caccaacagt 182100
gtaaaagcat tcctttttct ccacaacctc accagcatgt gttgggattt tttttttttt 182160
ttacttttca ataatagcca tctgactggt atgagatggt atctcagtgt ggttttgatt 182220
tttatttctt taatgatcag tgatgttaag ctctttttca tatacttgtt ggctgcatgt 182280
atgtcttctt ctaaaaagtg tctgctcatg tcctttgccc actttttaat gggattgttt 182340
aattttttct tgtgaattta cttaagttcc ttatagatgc tggttattag acccttctca 182400
gatttgtagc ttgcaaaaat gttcacccat tctgtgggtt gtcttcactc tgatgatagt 182460
ttcttttgct gtgcagaaga tcttcagttt agttagatcc catttgtcaa tttttgcttt 182520
tgttgcaatt gcttgatgtg ttttcatcat gaaatcttag cccattccta tatccagaat 182580
ggtattacct aggttgtctt ccagggtttt tatagtttgg ggttttacat ttaagtcttt 182640
aatccatgtt gagtttattt ttgtgtatgg tgtaaggaag gagtccagtt tcaatcttct 182700
tcatggctag ctagtcatca tttattgagt agggagtcct ttattcattg cttttttttt 182760
tttgtcaact ttgtcaacga tcacatggtt gtaggtgtgc agccttattt ctgggctctc 182820
tattctgttt cattggtctg tatgtctgtt tctgtactag taccatgctg ttttggttac 182880
tgtatccctg tagtttaaag tcaggtagca tcatgcttcc agctttgttc tttttgctta 182940
ggattgcctt ggcaattcag gctctttttt ggttccatgt gaatttttaa attgtatttt 183000
ctagttctgt gaagaatctc attggtagtg tgataggagt aacattgaat ctataaaata 183060
ctttgggcag tatagtcatt ttaatgatat tgattctttc tatccatgag catggaatgt 183120
ttttccattt gtttgtgtca tctctgattt ctttaagcag tgttttgtgg ttcttattgt 183180
agagatcttt cactttcctg gtttactgta tttctaggta ttttattctt tttgtggcaa 183240
ttgtgaattg aattgcattc ctgatttggt tctcagcttg actgttgttg gcatattgga 183300
atgctaatta tttttgtaca ttgattttgt acaactgagt cttcactgaa gttgtttatc 183360
agcttaaggg gttttgggtc aagactatgg ggttttctag atataggatc atgtcatctg 183420
caaacagaga tagctgtttt cctctcttcc tgtttggatg tccattattt ctttctctca 183480
cctgatttat ctggccagga cttccaatac tatgttaaat aggagtgttg agagagggaa 183540
tccttgtctt gtgtcaattt tcaaggggaa tgttttcaac ttttgcccat tcaatatgat 183600
gttggctgtg ggtttgccat agatggctaa tatgttgagg tttgttcttt aaatacctag 183660
tttattgaga attttaaaca tgttgaattt tattgagagc cttttctgca tctattgaga 183720
tgatcatgtg gcttttgtcc ttagttctgt ttgtgtggtg aatcacattt attgatttgc 183780
atatgttgaa ccaatcttgc atcccaggga tgaagccgac ttgattgtgg tggcttaagc 183840
tttttgatgt gctgctggat tcgatttgcc agtattttgt tgaggatttt tatgtctatg 183900
ttcatcagag atattggcct gaagttttct ttttttgttg tatctctgcc aagctttggt 183960
atcaggatga cattggcctc atagaatgag ttaaggaaga gtccctcctt ctcaattttt 184020
ttggaatagt ttcagtagga atggtaccag ctttttttgt acatcttgta gaatttggct 184080
atgaatccat ctagtcttag gctttgtttt ggttggtagg ctatttatta ctgattcaat 184140
tttggagctc attattggtc tgttcaggga ttcagtttct tcctgaggtt tttattttta 184200
tcaaatggaa cttaagcttt ttcatttcca atttttttat gatctaaaaa tgtgcagttt 184260
acagccctgt tcagaatctg catcttcctc attctgcaga tacaggtccc tcagagcagg 184320
tgactgagtg tgtatcctgt ctggagcata atacttatgc tagtagagtt actgttgtct 184380
ttattgttaa ttaccaaagt ttaccactta tcagtcactt actacttgct gggcattgca 184440
ctaagcattt cagttgtatt atcttgttgg gtccttacag caatcctgtg aaacagatac 184500
tgctattacc ccactttata gagaggtaga ctgaggcttc cagcattgaa gcaaattgcc 184560
caagactaca gaaatgtagg tttctaaaca tcaagaaaca gtaaccagta atgatgacta 184620
aagcaaggga ttgtgattgt tcattcatga tcccactgcc ttcttttctt gcttcatcct 184680
ctcaggggtg accgtttggg agttgatgac ctttggatcc aagccatatg acggaatccc 184740
tgccagcgag atctcctcca tcctggagaa aggagaacgc ctccctcagc cacccatatg 184800
taccatcgat gtctacatga tcatggtcaa gtgtgagtga ctggtgggtc tgtccacact 184860
gcctagctga gccttggtgg ctgctcttag ccaaacagct gaggcctttg catccctgga 184920
gaaatgtcat cacattactt aaggcaggca cacaaatcca gaaacatctg taaatacccc 184980
ttcaagcatt cttttaaaga cacttcttga ctcattgggc agtatgacct gacatttgcc 185040
catgtttgca agcaaataaa taaaactaaa gtcttccgca agccattaca ccaaaatatt 185100
ctattcgctg agttactcaa tgaaataccg agttgcccta tattttgaag cctgttacca 185160
gagagactga atgtttttaa atgcatggca gtgagtaaca acataaggct aatagagtca 185220
acatttctgc tttgacttaa accttttaaa ccagtggatt tatgtgaagt ctctgcagtg 185280
tggcatttaa acatttcaat ctaaataaga gtgtgtaatt tgattgatgc tattattcta 185340
ccagattcac gagtgcagtg ggctctggag gtagcattac atgcatggga tgagcatttg 185400
caaaagaaag ttgtataggg aatatgacag agccaagtta atgtaaatat taatgccttt 185460
ctgaactcta ggccacagag ttgatctttt ttaacttcct tggtttgggc taaggaagct 185520
gtgatccaga gaagccacgt gatttgtcta aggtcacata gcagtctggc ctaaaatagc 185580
ttgatatgct gtggatggaa aataaatgtg atccctcaag aggcatgagg atttccaggc 185640
agtagccata cctccaaatt gtttaatctg gatttagatt gttgggtagt cacatgcagc 185700
agcacagtta acagtgtgtc ctcctgtgga agttgccagc acagccagcc ctctcacttg 185760
catgcatgcc caccagcctt ctcacttgca tgcatgccca ctgggtatgt gctgtactgg 185820
agacgccggg ggtaggggcc cagtcccaac cccaaattct ttaaagccta tttttctaag 185880
ttgcatctgg tttcctacct gaaggaatgc taagggtgga tgttgagtga ggaccttggt 185940
gcagggcacc ctgcagtcag gatagttcat ggagagcaat tgtacagacc cacactgctc 186000
catcccctca ggcgtaacac aggatgctga ccccaggaag agtgggcgta gaaaaactag 186060
agggcattat tgttattctg attcaaatgt acagtgctgg catggtcttt aaacagtaac 186120
cagtactagc tggccaagac agaaaagtct accacaaaga cttggttctt tcatcactta 186180
tttgactgga agtgtcgcat caccaatgcc ttctttaagc aatgccatct ttatcatttc 186240
ttccagtgtt ctaattgcac tgttttttct cattccttcc ccaggctgga tgatagacgc 186300
agatagtcgc ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc 186360
ccagcgctac cttgtcattc aggtacaaat tgcagtctgt gcttccattg ggaagagtcc 186420
ctctaatgag catctcatgt cactgtgttc tgtcacatgc cagcctggcc tccctgtgtc 186480
ccagatcgca ttattaaacc ctccagcgca ttagagcaag cctcagtaag gcgcaggcca 186540
catcgtgaac taagcagcat ccgtgagtgg ggcccaccca actccatctc cccctccccg 186600
tctgaactct cctctggtgc tcgtcctcac tgtccggcta gccaaagcct cagctgggtc 186660
taagagagaa gcatggtcta ttgggctttg gtgtcaggca gacgtggctt cacacccctg 186720
actctccact tcttcgcatc acccaggcag ccgatccacc tatctccttc cataacacag 186780
gaataccaaa accaagctca caggattgtc tcaaagattc aataaaatat gttgcaaaat 186840
acgctcccta acacctcaca gcaaggtgca cactcgatga atgctgcagc ttcttccctt 186900
tctgtttcct cagaagctat ttgaatctca tgtaggggct ttcaagcatc aaaggatggt 186960
tcatgtttta ttttaaggca cccacatcat gtcatgaggg gaggcagcta taatttagag 187020
aaccaagggg gatttcatta taacaaaatt ggcaaacaca caggcacctg ctggcaatag 187080
acccctgctc ctatagccaa gaagtggaat agcatctcta cgggccattc taatagcctc 187140
aaaatctctg caccaggggg atgaaagaat gcatttgcca agtcctacag actccaactt 187200
ctaccgtgcc ctgatggatg aagaagacat ggacgacgtg gtggatgccg acgagtacct 187260
catcccacag cagggcttct tcagcagccc ctccacgtca cggactcccc tcctgagctc 187320
tctggtatga aatctctgtc tctctctctc tctcaagctg tgtctactca tttgaacaaa 187380
ttgaatttta gggaaaataa ccatctagtg aaactcacat ggatatgaag tcaattttaa 187440
ccaaatggta aaatcaaaat caaaataaat taagtgtatt aattattttg ttgcattgca 187500
acaacttgat tgtaagcctt ttaggtccac tatggaatgt aattaaatca aaactaaacc 187560
tagttgctct aaaactaacg attaagacaa aaattaaaca ccttcacaat ataccctcca 187620
tgaggcacac cacctgcatt caggaaaagt ggatgagatg tggtacaagc attccatggg 187680
caacttctct gtttcttttt cagagtgcaa ccagcaacaa ttccaccgtg gcttgcattg 187740
atagaaatgg ggtatgtatg aacaccttat aagccagaat ttacagctct ccactatggc 187800
tctattttac atggaaaatg ccttaaccta aataatttta acccagataa tcttgagttt 187860
tcttcctgtg tgggtttttc cctgcacggc tgtcacgcct cacagtgccg ttcaaagcgt 187920
gactcctgga ccagtagtag catcgcctgg ccttgttaga aacgccattt ttcaggccac 187980
tgccccagtt tgaccaaatc aggacctctg ggggtggcac ccagtagtct atgtttgagc 188040
cactttccag gtgatgctga tgtctgttga agtgtgaggc cgtggtctag accgcactgt 188100
gccatgcaga aaccactagc cacatgtggc tacttcaact taaatgttaa tgagttaaaa 188160
tgaaataaaa tataaaattc agtttctcac acatgtgaag tgtccagtag ccacacgtgg 188220
ctagtggtga ccgtattgaa gagcaccgct catagcacac ctccctcact gcggaaagtt 188280
ctgctgtaca gcacccagca cagccctgct gcccaccctg cagcctgtgg cccagtagca 188340
ccagcaccca ccagggtgca gactctcagg cctgcccaac ctactaatca gaaccagcat 188400
ctcaaggaga tctcgggtga tttttgcaaa cactgaagtt ggggcagccc tgaccggagt 188460
aaccttccct catttcctcc tgcagctgca aagctgtccc atcaaggaag acagcttctt 188520
gcagcgatac agctcagacc ccacaggcgc cttgactgag gacagcatag acgacacctt 188580
cctcccagtg cctggtgagt ggcttgtctg gaaacagtcc tgctcctcaa cctcctcgac 188640
ccactcagca gcagccagtc tccagtgtcc aagccaggtg ctccctccag catctccaga 188700
gggggaaaca gtggcagatt tgcagacaca gtgaagggcg taaggagcag ataaacacat 188760
gaccgagcct gcacaagctc tttgttgtgt ctggttgttt gctgtacctc tgttgtaaga 188820
atgaatctgc aaaatttcta gcttatgaag caaatcacgg acatacacat ctgtgtgtgt 188880
gagtgttcat gatgtgtgta catctgtgta tgtgtgtgtg tgtatgtgtg tgtttgtgac 188940
agatttgatc cctgttctct ctgctggctc tatcttgacc tgtgaaacgt atatttaact 189000
aattaaatat tagttaatat taataaattt taagctttat ccagatactc ataacctgct 189060
aacacacaca catatacaca cacatacaca tacacacata tacacacacc acacacatac 189120
acagacacca cacacatacc atacacagac acatacacat gcacacacat atacacacac 189180
acctcaaata catacacacc acacacacat acatgtatac acacatacac acaccacaca 189240
tacaccacaa aaaccccaca cacatacaca tatacacacc acacacacca catacacaca 189300
cgtatacaca catatataca cacatacacc atgcatacat acacaccaca catacataca 189360
gacacaccac acacacgtac acacaacaca caacacagac acgtacacac actacagaca 189420
tgtatgcaca catacacaca caccacacat acatacacac agacacatat acactacaca 189480
caccattaca tacacacgta cacatacacc acacacacca cacatacaca caccacacac 189540
acatacgcca cacacacacc acaaaaaccg cacacacata caaacatata cacactacac 189600
cacacataca cacacacacc acacaccaca cacacacata cacacaccac acacaccaca 189660
catacacgca ccacacatac acacacgtag acacaccaca cacaccacag aaacacacat 189720
taacacacca catacacata tgtatgtgca tatacacacc cacaccccac acacacatgt 189780
ataaagattt agatatatat aaaacatatg ttatatatat gttgatgtaa tatctaatat 189840
ctatatatct aatatgtagt ttattagcta tctaatatct atgtcatata tatcaaaatc 189900
tttatatata aaaatatgta gaaatcttta tacatatgtt atatgtatat aaagatttag 189960
atatataaca tatgtaagtt atatatatgt tagtgtaata tctaatatat agtttattgg 190020
ctatctaata taatataaac agattatcaa tattataagc tattagaaaa atgcaagtta 190080
aggcagatga tatacctctt tacacaccaa ctacacacac caactacaca cacacataca 190140
cacagacaca cacgacacac accatacaca tgtacacaca caccacatat acacaaacgt 190200
acacacacac cacacacaca tacacaccac acacacacca cacatacata cacatccaca 190260
caccacacat gtacacacgc cacacacaca catacacacc acatacacat atgtatgcac 190320
acatacacac caacaccaca cagacaccac acatgcataa acatatagac atatacacac 190380
cacacaccat atgtacacat gtacacacac accacatata cacacaacac acacaaatac 190440
acacaccaca cacacaccac aaaaacccca cacacacaca aacatataca ccccacacat 190500
acgcatatat acacacacac atacacacca cacacataca caccacacac acaccacaca 190560
tacacacacg tacacacacc acacacacac cacagacaca caccacacat acatacacat 190620
acacacacca cacacacgta cacacaccac acacaccaca gacacacata gacacaccac 190680
atacacaccc acaccacaca cacacaactc ataccacaca tacatacaca atagacacat 190740
acacaccaca cacaccatac atacacacgt atacacacac cacatataca cacacgtaca 190800
cacacaccac acacacccac atgcacacac cacacacaca tacaaatata caccacacac 190860
acatacacca cacacacggt gcacatacac acacatatac acacaccaga cacacatacc 190920
acatacacat cacacatata tgtatacatg catacacata cacacacaca tacacacact 190980
ctcctcaagg cagtttatcc tctgagaact ttaaatttac aaaagacaca tatgtccatt 191040
actttgagaa ggacaggaaa gaacccactt tcttttgcag caacagcaag agggccctcc 191100
cgaggctcct gctccctgtc ataagtctcc ttgttgagga cattcacagg gttcagaacc 191160
cagggatcct gcatgggatg gtgctttgct gattacttca cctctgattt ctttccactt 191220
tcagaataca taaaccagtc cgttcccaaa aggcccgctg gctctgtgca gaatcctgtc 191280
tatcacaatc agcctctgaa ccccgcgccc agcagagacc cacactacca ggacccccac 191340
agcactgcag tgggcaaccc cgagtatctc aacactgtcc agcccacctg tgtcaacagc 191400
acattcgaca gccctgccca ctgggcccag aaaggcagcc accaaattag cctggacaac 191460
cctgactacc agcaggactt ctttcccaag gaagccaagc caaatggcat ctttaagggc 191520
tccacagctg aaaatgcaga atacctaagg gtcgcgccac aaagcagtga atttattgga 191580
gcatgaccac ggaggatagt atgagcccta aaaatccaga ctctttcgat acccaggacc 191640
aagccacagc aggtcctcca tcccaacagc catgcccgca ttagctctta gacccacaga 191700
ctggttttgc aacgtttaca ccgactagcc aggaagtact tccacctcgg gcacattttg 191760
ggaagttgca ttcctttgtc ttcaaactgt gaagcattta cagaaacgca tccagcaaga 191820
atattgtccc tttgagcaga aatttatctt tcaaagaggt atatttgaaa aaaaaaaaaa 191880
gtatatgtga ggatttttat tgattgggga tcttggagtt tttcattgtc gctattgatt 191940
tttacttcaa tgggctcttc caacaaggaa gaagcttgct ggtagcactt gctaccctga 192000
gttcatccag gcccaactgt gagcaaggag cacaagccac aagtcttcca gaggatgctt 192060
gattccagtg gttctgcttc aaggcttcca ctgcaaaaca ctaaagatcc aagaaggcct 192120
tcatggcccc agcaggccgg atcggtactg tatcaagtca tggcaggtac agtaggataa 192180
gccactctgt cccttcctgg gcaaagaaga aacggagggg atggaattct tccttagact 192240
tacttttgta aaaatgtccc cacggtactt actccccact gatggaccag tggtttccag 192300
tcatgagcgt tagactgact tgtttgtctt ccattccatt gttttgaaac tcagtatgct 192360
gcccctgtct tgctgtcatg aaatcagcaa gagaggatga cacatcaaat aataactcgg 192420
attccagccc acattggatt catcagcatt tggaccaata gcccacagct gagaatgtgg 192480
aatacctaag gatagcaccg cttttgttct cgcaaaaacg tatctcctaa tttgaggctc 192540
agatgaaatg catcaggtcc tttggggcat agatcagaag actacaaaaa tgaagctgct 192600
ctgaaatctc ctttagccat caccccaacc ccccaaaatt agtttgtgtt acttatggaa 192660
gatagttttc tccttttact tcacttcaaa agctttttac tcaaagagta tatgttccct 192720
ccaggtcagc tgcccccaaa ccccctcctt acgctttgtc acacaaaaag tgtctctgcc 192780
ttgagtcatc tattcaagca cttacagctc tggccacaac agggcatttt acaggtgcga 192840
atgacagtag cattatgagt agtgtggaat tcaggtagta aatatgaaac tagggtttga 192900
aattgataat gctttcacaa catttgcaga tgttttagaa ggaaaaaagt tccttcctaa 192960
aataatttct ctacaattgg aagattggaa gattcagcta gttaggagcc cacctttttt 193020
cctaatctgt gtgtgccctg taacctgact ggttaacagc agtcctttgt aaacagtgtt 193080
ttaaactctc ctagtcaata tccaccccat ccaatttatc aaggaagaaa tggttcagaa 193140
aatattttca gcctacagtt atgttcagtc acacacacat acaaaatgtt ccttttgctt 193200
ttaaagtaat ttttgactcc cagatcagtc agagccccta cagcattgtt aagaaagtat 193260
ttgatttttg tctcaatgaa aataaaacta tattcatttc cactctatta tgctctcaaa 193320
tacccctaag catctatact agcctggtat gggtatgaaa gatacaaaga taaataaaac 193380
atagtccctg attctaagaa attcacaatt tagcaaagga aatggactca tagatgctaa 193440
ccttaaaaca acgtgacaaa tgccagacag gacccatcag ccaggcactg tgagagcaca 193500
gagcagggag gttgggtcct gcctgaggag acctggaagg gaggcctcac aggaggatga 193560
ccaggtctca gtcagcgggg aggtggaaag tgcaggtgca tcaggggcac cctgaccgag 193620
gaaacagctg ccagaggcct ccactgctaa agtccacata aggctgaggt cagtcaccct 193680
aaacaacctg ctccctctaa gccaggggat gagcttggag catcccacaa gttccctaaa 193740
agttgcagcc cccaggggga ttttgagcta tcatctctgc acatgcttag tgagaagact 193800
acacaacatt tctaagaatc tgagatttta tattgtcagt taaccacttt cattattcat 193860
tcacctcagg acatgcagaa atatttcagt cagaactggg aaacagaagg acctacattc 193920
tgctgtcact tatgtgtcaa gaagcagatg atcgatgagg caggtcagtt gtaagtgagt 193980
cacattgtag cattaaattc tagtattttt gtagtttgaa acagtaactt aataaaagag 194040
caaaagctat tctagctttc ttcttcatat tttaattttc caccataaag tttagttgct 194100
aaattctatt aattttaaga ttgtgcttcc caaaatagtt ctcacttcat ctgtccaggg 194160
aggcacagtt ctgtctggta gaagccgcaa agcccttagc ctcttcacgg atctggcgac 194220
tgtgatgggc aggtcaggag aggagctgcc caaagtccca tgattttcac ctaacagccc 194280
tgatcagtca gtactcaaag cttggactcc atccctgaag gtcttcctga ttgatagcct 194340
ggccttaata ccctacagaa agcctgtcca ttggctgttt cttcctcagt cagttcctgg 194400
aagaccttac cccatgaccc cagcttcaga tgtggtcttt ggaaacagag gtcgaaggaa 194460
agtaaggagc tgagagctca cattcatagg tgccgccagc cttcgtgcat cttcttgcat 194520
catctctaag gagctcctct aattacacca tgcccgtcac cccatgaggg atcagagaag 194580
ggatgagtct tctaaactct atattcgctg tgagtccagg ttgtaagggg gagcactgtg 194640
gatgcatcct attgcactcc agctgatgac accaaagctt aggtgtttgc tgaaagttct 194700
tgatgttgtg acttaccacc cctgcctcac aactgcagac ataaggggac tatggattgc 194760
ttagcaggaa aggcactggt tctcaagggc ggctgccctt gggaatcttc tggtcccaac 194820
cagaaagact gtggcttgat tttctcaggt gcagcccagc cgtagggcct tttcagagca 194880
ccccctggtt attgcaacat tcatcaaagt ttctagaacc tctggcctaa aggaagggcc 194940
tggtgggatc tacttggcac tcgctggggg gccacccccc agtgccactc tcactaggcc 195000
tctgattgca cttgtgtagg atgaagctgg tgggtgatgg gaactcagca cctcccctca 195060
ggcagaaaag aatcatctgt ggagcttcaa aagaaggggc ctggagtctc tgcagaccaa 195120
ttcaacccaa atctcggggg ctctttcatg attctaatgg gcaaccaggg ttgaaaccct 195180
tatttctagg gtcttcagtt gtacaagact gtgggtctgt accagagccc ccgtcagagt 195240
agaataaaag gctgggtagg gtagagattc ccatgtgcag tggagagaac aatctgcagt 195300
cactgat 195307
<210> 10
<211> 1210
<212> PRT
<213> Homo sapiens
<400> 10
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
1 5 10 15
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
20 25 30
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
35 40 45
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
50 55 60
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65 70 75 80
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
85 90 95
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
100 105 110
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
115 120 125
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
130 135 140
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145 150 155 160
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
165 170 175
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
180 185 190
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
195 200 205
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
210 215 220
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225 230 235 240
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
245 250 255
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
260 265 270
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
275 280 285
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
290 295 300
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305 310 315 320
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
325 330 335
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
340 345 350
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
355 360 365
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
370 375 380
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385 390 395 400
Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
405 410 415
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln
420 425 430
His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu
435 440 445
Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser
450 455 460
Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465 470 475 480
Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Arg Asn Arg Gly Glu
485 490 495
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro
500 505 510
Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn
515 520 525
Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
530 535 540
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro
545 550 555 560
Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro
565 570 575
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val
580 585 590
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
595 600 605
Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys
610 615 620
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly
625 630 635 640
Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu
645 650 655
Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His
660 665 670
Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu
675 680 685
Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu
690 695 700
Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser
705 710 715 720
Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu
725 730 735
Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser
740 745 750
Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser
755 760 765
Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser
770 775 780
Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp
785 790 795 800
Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn
805 810 815
Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg
820 825 830
Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro
835 840 845
Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala
850 855 860
Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp
865 870 875 880
Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp
885 890 895
Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser
900 905 910
Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu
915 920 925
Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr
930 935 940
Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys
945 950 955 960
Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln
965 970 975
Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro
980 985 990
Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp
995 1000 1005
Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe
1010 1015 1020
Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu
1025 1030 1035
Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn
1040 1045 1050
Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg
1055 1060 1065
Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp
1070 1075 1080
Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro
1085 1090 1095
Lys Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln
1100 1105 1110
Pro Leu Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro
1115 1120 1125
His Ser Thr Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln
1130 1135 1140
Pro Thr Cys Val Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala
1145 1150 1155
Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln
1160 1165 1170
Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe Lys
1175 1180 1185
Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln
1190 1195 1200
Ser Ser Glu Phe Ile Gly Ala
1205 1210
<210> 11
<211> 20
<212> DNA
<213> Artificial
<220>
<223> Direct primer amplification exon 12 of EGFR gene
<400> 11
ttgcagtcgt cagcctgaac 20
<210> 12
<211> 26
<212> DNA
<213> Artificial
<220>
<223> Reverse primer amplification exon 12 of EGFR gene
<400> 12
ttaaatggga atagcccttc aatatt 26
<210> 13
<211> 25
<212> DNA
<213> Homo sapiens
<400> 13
ccaaaattat aaggaacaga ggtga 25
<210> 14
<211> 25
<212> DNA
<213> Homo sapiens
<400> 14
ccaaaattat acgtaacaga ggtga 25
<210> 15
<211> 25
<212> DNA
<213> Homo sapiens
<400> 15
ccaaaattat acgcaacaga ggtga 25
<210> 16
<211> 25
<212> DNA
<213> Homo sapiens
<400> 16
ccaaaattat acgaaacaga ggtga 25
<210> 17
<211> 25
<212> DNA
<213> Homo sapiens
<400> 17
ccaaaattat acggaacaga ggtga 25
Claims (15)
- SEQ ID NO: 1(TKIIRNRGE)을 포함하는 것을 특징으로 하는 펩티드 서열.
- SEQ ID NO: 1에 대한 서열 코딩을 포함하는 것을 특징으로 하는 올리고뉴클레오티드.
- 제 2항에 있어서,
SEQ ID NO: 2, SEQ ID NO:13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16 및 SEQ ID NO: 17으로 구성되는 그룹으로부터 선택된 핵산 서열을 포함하는 것을 특징으로 하는 올리고뉴클레오티드. - SEQ ID No: 3 (gggacctccggtcagaaaa) 및 SEQ ID No: 4 (cggtgacttactgcagctgttt)로 구성되는 것을 특징으로 하는 프라이머의 세트.
- SEQ ID NO: 5 (cacctctgtttcttataatt)로 구성되는 것을 특징으로 하는 올리고뉴클레오티드.
- SEQ ID NO: 6 (cacctctgttgcttataa)로 구성되는 것을 특징으로 하는 올리고뉴클레오티드.
- 청구항 제 5항에서 정의된 바와 같은 올리고뉴클레오티드를 포함하는 것을 특징으로 하는 키트.
- 제 7항에 있어서,
청구항 제 6항에서 정의된 바와 같은 상기 올리고뉴클레오티드를 더 포함하는 것을 특징으로 하는 키트. - 제 7항 또는 제 8항에 있어서,
청구항 제 4항에 정의된 바와 같은 프라이머의 세트를 더 포함하는 것을 특징으로 하는 키트. - 제 7항 내지 제 9항 중 어느 한 항에 있어서,
KRAS 및/또는 PIK3CA 및/또는 BRAF 유전자에서 돌연변이를 검출하기 위한 시약을 더 포함하는 것을 특징으로 하는 키트. - 세투시마브 및/또는 패니투무마브를 포함하는 치료 요법에 대한 환자의 반응의 예측에서의 사용을 위한 청구항 제 7항 내지 제 10항 중 어느 한 항에서 정의된 바와 같은 키트.
- 제 11항에 있어서,
상기 환자는 암으로 영향받는 것을 특징으로 하는 사용을 위한 키트. - 제 12항에 있어서,
상기 암은 전이성 결장암 및 두경부암으로 구성되는 그룹으로부터 선택되는 것을 특징으로 하는 사용을 위한 키트. - 유전자형 방법, 및/또는 단백질 서열화 방법으로 구성되는 그룹으로부터 선택된 수단에 의해 SEQ ID NO: 8의 위치 492에서 아미노산을 결정하는 단계를 포함하는 것을 특징으로 하는 환자로부터 취해진 시료에서 SEQ ID NO: 8에 대응하는 아미노산 서열의 위치 492에서 아르기닌의 존재 또는 부재를 식별하는 인 비트로 방법.
- 세투시마브 및/또는 패니투무마브를 포함하는 대상 치료 요법의 반응을 예측하는 인 비트로 방법으로서, 상기 방법은: ⅰ) 청구항 제 14항의 방법에서 정의된 바와 같이, 환자로부터 취해진 시료에서 SEQ ID NO: 8에 대응하는 아미노산 서열의 위치 492에서 아르기닌의 존재 또는 부재를 결정하는 단계; ⅱ) 상기 세투시마브를 포함하는 상기 치료 요법에 대한 환자의 저항과 단계 ⅰ)에서 식별된 상기 아르기닌의 존재를 상관시키는 단계, 또는 상기 패니투무마브를 포함하는 치료 요법에 대한 대상의 반응과 단계 ⅰ)에서 식별된 상기 아르기닌의 부재를 상관시키는 단계를 포함하는 것을 특징으로 세투시마브 및/또는 패니투무마브를 포함하는 대상 치료 요법의 반응을 예측하는 인 비트로 하는 방법.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP11382270.4 | 2011-08-03 | ||
EP11382270A EP2554551A1 (en) | 2011-08-03 | 2011-08-03 | Mutations in the epidermal growth factor receptor gene |
PCT/EP2012/065090 WO2013017645A1 (en) | 2011-08-03 | 2012-08-02 | Mutations in the epidermal growth factor receptor gene |
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KR20140072035A true KR20140072035A (ko) | 2014-06-12 |
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KR1020147005437A KR20140072035A (ko) | 2011-08-03 | 2012-08-02 | 상피세포 성장 인자 수용체 유전자에서의 돌연변이 |
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US (1) | US9765399B2 (ko) |
EP (3) | EP2554551A1 (ko) |
JP (1) | JP6149034B2 (ko) |
KR (1) | KR20140072035A (ko) |
CN (1) | CN103717616B (ko) |
AU (1) | AU2012292024A1 (ko) |
BR (1) | BR112014002373A2 (ko) |
CA (1) | CA2842270C (ko) |
ES (1) | ES2556468T3 (ko) |
IN (1) | IN2014CN00570A (ko) |
RU (1) | RU2014107908A (ko) |
WO (1) | WO2013017645A1 (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
WO2015175705A1 (en) | 2014-05-13 | 2015-11-19 | Board Of Regents, The University Of Texas System | Gene mutations and copy number alterations of egfr, kras and met |
MA39599A (fr) | 2014-05-14 | 2016-10-05 | Merrimack Pharmaceuticals Inc | Dosage et administration d'agents thérapeutiques anti-egfr |
US11015225B2 (en) * | 2014-07-28 | 2021-05-25 | Alberto Bardelli | Method of treating cancer based on identifying mutations in the extracellular domain III of epidermal growth factor receptor gene |
CN104531854B (zh) * | 2014-11-10 | 2017-01-18 | 中国人民解放军第三〇七医院 | 检测西妥昔单抗治疗转移性结直肠癌耐药的试剂盒 |
CA2983890A1 (en) * | 2015-04-24 | 2016-10-27 | Merrimack Pharmaceuticals, Inc. | Methods of treating patients having mutations in the extracellular domain of epidermal growth factor receptor (egfr) with a combination of three fully human monoclonal anti-egfr antibodies |
RU2626682C1 (ru) * | 2016-07-20 | 2017-07-31 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ прогнозирования резистентности опухоли к таргетной терапии цетуксимабом у больных плоскоклеточным раком языка и слизистой дна полости рта |
CN111499749B (zh) * | 2020-03-13 | 2021-11-09 | 浙江大学 | 一种西妥昔单抗突变体及应用 |
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CA2558753A1 (en) | 2004-03-01 | 2005-09-15 | University Of Chicago | Polymorphisms in the epidermal growth factor receptor gene promoter |
TW200533339A (en) | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
US20110142822A1 (en) * | 2004-06-14 | 2011-06-16 | Kussie Paul H | Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof |
JP2008535477A (ja) * | 2005-02-24 | 2008-09-04 | アムジエン・インコーポレーテツド | 上皮成長因子受容体変異 |
CN1737162A (zh) * | 2005-03-16 | 2006-02-22 | 南京中医药大学附属医院(江苏省中医院) | 表皮生长因子受体(egfr)基因测序检测方法 |
US7981606B2 (en) * | 2005-12-21 | 2011-07-19 | Roche Molecular Systems, Inc. | Control for nucleic acid testing |
AU2007329740B2 (en) * | 2006-10-26 | 2014-05-01 | Genentech, Inc. | Genetic variations associated with tumors |
CA2675362A1 (en) | 2007-01-18 | 2008-07-24 | University Of Southern California | Polymorphisms in the egfr pathway as markers for cancer treatment |
WO2008091701A2 (en) * | 2007-01-25 | 2008-07-31 | Dana-Farber Cancer Institute | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
US8137919B2 (en) * | 2008-04-10 | 2012-03-20 | Montefiore Medical Center | Method of determining the sensitivity of cancer cells to EGFR inhibitors including cetuximab, panitumumab and erlotinib |
US8583380B2 (en) * | 2008-09-05 | 2013-11-12 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
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2011
- 2011-08-03 EP EP11382270A patent/EP2554551A1/en not_active Withdrawn
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2012
- 2012-08-02 AU AU2012292024A patent/AU2012292024A1/en not_active Abandoned
- 2012-08-02 WO PCT/EP2012/065090 patent/WO2013017645A1/en active Application Filing
- 2012-08-02 CA CA2842270A patent/CA2842270C/en active Active
- 2012-08-02 KR KR1020147005437A patent/KR20140072035A/ko not_active Application Discontinuation
- 2012-08-02 CN CN201280037669.7A patent/CN103717616B/zh active Active
- 2012-08-02 EP EP12745460.1A patent/EP2739648B1/en active Active
- 2012-08-02 JP JP2014523328A patent/JP6149034B2/ja active Active
- 2012-08-02 BR BR112014002373A patent/BR112014002373A2/pt not_active Application Discontinuation
- 2012-08-02 ES ES12745460.1T patent/ES2556468T3/es active Active
- 2012-08-02 RU RU2014107908/10A patent/RU2014107908A/ru not_active Application Discontinuation
- 2012-08-02 US US14/236,614 patent/US9765399B2/en active Active
- 2012-08-02 IN IN570CHN2014 patent/IN2014CN00570A/en unknown
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Also Published As
Publication number | Publication date |
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ES2556468T3 (es) | 2016-01-18 |
CA2842270A1 (en) | 2013-02-07 |
JP6149034B2 (ja) | 2017-06-14 |
RU2014107908A (ru) | 2015-09-10 |
EP2739648B1 (en) | 2015-09-16 |
EP2739648A1 (en) | 2014-06-11 |
AU2012292024A1 (en) | 2014-02-27 |
US20140170662A1 (en) | 2014-06-19 |
CN103717616A (zh) | 2014-04-09 |
US9765399B2 (en) | 2017-09-19 |
JP2014521342A (ja) | 2014-08-28 |
CN103717616B (zh) | 2016-06-29 |
CA2842270C (en) | 2019-10-29 |
EP2995623A1 (en) | 2016-03-16 |
BR112014002373A2 (pt) | 2017-02-21 |
IN2014CN00570A (ko) | 2015-04-03 |
WO2013017645A1 (en) | 2013-02-07 |
EP2554551A1 (en) | 2013-02-06 |
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