CN114983836A - Repairing type freeze-dried wadding and preparation method thereof - Google Patents
Repairing type freeze-dried wadding and preparation method thereof Download PDFInfo
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- CN114983836A CN114983836A CN202210681829.7A CN202210681829A CN114983836A CN 114983836 A CN114983836 A CN 114983836A CN 202210681829 A CN202210681829 A CN 202210681829A CN 114983836 A CN114983836 A CN 114983836A
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- 238000002360 preparation method Methods 0.000 title claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 16
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 16
- 229930195725 Mannitol Natural products 0.000 claims abstract description 16
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 16
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 16
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 16
- 235000010489 acacia gum Nutrition 0.000 claims abstract description 16
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 16
- 239000000594 mannitol Substances 0.000 claims abstract description 16
- 235000010355 mannitol Nutrition 0.000 claims abstract description 16
- 239000008213 purified water Substances 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 230000008439 repair process Effects 0.000 claims abstract description 16
- 229940016667 resveratrol Drugs 0.000 claims abstract description 16
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 16
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 16
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 16
- 229920001218 Pullulan Polymers 0.000 claims abstract description 15
- 239000004373 Pullulan Substances 0.000 claims abstract description 15
- 235000019423 pullulan Nutrition 0.000 claims abstract description 15
- 229920000084 Gum arabic Polymers 0.000 claims abstract description 14
- 239000000205 acacia gum Substances 0.000 claims abstract description 14
- 238000001035 drying Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 239000011265 semifinished product Substances 0.000 claims description 6
- 238000004108 freeze drying Methods 0.000 claims description 5
- 238000011049 filling Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000007710 freezing Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 230000037303 wrinkles Effects 0.000 abstract description 13
- 230000032683 aging Effects 0.000 abstract description 5
- 102000008186 Collagen Human genes 0.000 abstract description 3
- 108010035532 Collagen Proteins 0.000 abstract description 3
- 229920001436 collagen Polymers 0.000 abstract description 3
- 238000005562 fading Methods 0.000 abstract description 3
- 230000008929 regeneration Effects 0.000 abstract description 3
- 238000011069 regeneration method Methods 0.000 abstract description 3
- 230000022131 cell cycle Effects 0.000 abstract description 2
- 210000004177 elastic tissue Anatomy 0.000 abstract description 2
- 230000008591 skin barrier function Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 17
- 239000002537 cosmetic Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0254—Platelets; Flakes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W10/00—Technologies for wastewater treatment
- Y02W10/10—Biological treatment of water, waste water, or sewage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a repair type freeze-dried wadding which comprises the following raw materials in percentage by mass: 80-90% of purified water, 0.5-5.0% of pullulan, 0.1-0.5% of sodium hyaluronate, 0.1-0.5% of mannitol, 0.5-1% of trehalose, 2-5% of acacia gum extract and 2-5% of resveratrol; the freeze-dried wadding prepared by the invention has good stability, can reconstruct a skin barrier, has super strong cell regeneration and repair capability, can quickly replace aging atrophied cells, prolong the cell division cycle, and promote collagen and elastic fibers to be linearly arranged, so that the skin is intensively repaired, the skin is recovered to be young, and the freeze-dried wadding has the functions of resisting aging and fading fine wrinkles.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a repairing type freeze-dried wadding and a preparation method thereof.
Background
The freeze-dried wadding is in the medical field, is mainly used for stopping bleeding, promoting wound healing, participating in tissue and nerve regeneration, reducing scar formation and the like, and is known as 'hemostatic sponge'; the freeze-dried floc is active collagen with strong skin repairing function;
with the improvement of living standard, people begin to pay attention to the image problem of themselves, the demand of cosmetics is gradually increased, the product types of the existing cosmetics are generally in the states of water cream and the like, the skin state can not be really improved, and the added preservative is generally more irritant and can easily cause certain adverse reactions to sensitive skin of consumers; therefore, a loose flocculent preparation which can better improve the skin state and has the functions of resisting aging and fading fine wrinkles is needed.
Disclosure of Invention
The invention aims to provide a repairing type freeze-dried wadding and a preparation method thereof, and aims to solve the problems that the existing cosmetics are generally in the states of water cream and the like, the skin state cannot be really improved, and the added preservative is generally high in irritation and can easily cause certain adverse reactions to sensitive skin of consumers.
In order to achieve the purpose, the invention provides the following technical scheme: a repair type freeze-dried wadding comprises the following raw materials in percentage by mass: 80-90% of purified water, 0.5-5.0% of pullulan, 0.1-0.5% of sodium hyaluronate, 0.1-0.5% of mannitol, 0.5-1% of trehalose, 2-5% of acacia gum extract and 2-5% of resveratrol.
The freeze-dried wadding comprises the following raw materials in percentage by mass: 86% of purified water, 2% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 5% of acacia gum extract and 5% of resveratrol.
The freeze-dried wadding comprises the following raw materials in percentage by mass: 86% of purified water, 3% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 4.5% of acacia gum extract and 4.5% of resveratrol.
The freeze-dried wadding comprises the following raw materials in percentage by mass: 86% of purified water, 5.0% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 3.5% of acacia gum extract and 3.5% of resveratrol.
A preparation method of a repairing type freeze-dried wadding comprises the following steps:
step 1, respectively weighing raw materials according to a formula ratio for subsequent use;
step 2, uniformly stirring pullulan, sodium hyaluronate, mannitol and trehalose to obtain an A-phase material, uniformly dissolving the A-phase material and purified water, filtering through a 200-mesh filter screen to obtain a filtered solution, and standing at normal temperature for later use;
step 3, uniformly stirring the Arabic gum extract and the resveratrol, filtering through a 200-mesh filter screen to obtain a B-phase material, and standing at normal temperature;
step 4, adding the solution obtained in the step 2 and the B-phase material into a stirring kettle, and uniformly stirring to obtain a semi-finished product;
step 5, filling, subpackaging and plugging the qualified semi-finished product, wherein the allowable filling tolerance is +1 ml;
and 6, putting the subpackaged semi-finished products into a freeze dryer for freeze drying to obtain the freeze-dried wadding.
The freeze drying of the freeze dryer comprises prefreezing, refrigerating by a water catcher, primary drying and secondary drying.
Wherein the pre-freezing set temperature is-45 ℃, the set time is 120 minutes, and the duration time is 120 minutes;
the set temperature of a cold well refrigerated by the water catcher is-45 ℃, the duration time is 10 minutes, then the pre-vacuum is 300Pa, the pre-vacuum time is 30 minutes, and the duration time is 30 minutes;
the primary drying comprises a first stage, a second stage and a third stage; the set temperature of the first stage is-20 ℃, the set time is 30 minutes, the duration time is 60 minutes, and the vacuum value is 30 Pa; the set temperature of the second stage is-10 ℃, the set time is 30 minutes, the duration time is 60 minutes, and the vacuum value is 30 Pa; the set temperature of the third stage is 0 ℃, the set time is 60 minutes, the duration time is 240 minutes, and the vacuum value is 30 Pa;
the secondary drying comprises a first stage, a second stage and a third stage; the set temperature of the first stage is 10 ℃, the set time is 60 minutes, the duration time is 120 minutes, and the vacuum value is 30 Pa; the set temperature of the second stage is 20 ℃, the set time is 60 minutes, the duration time is 120 ℃, and the vacuum value is 10 Pa; the third stage was set at 25 ℃ for 30 minutes with a duration of 180 minutes and a vacuum of 10 Pa.
Compared with the prior art, the invention has the beneficial effects that:
the freeze-dried wadding prepared by the method has good stability, can reconstruct a skin barrier, has super strong cell regeneration and repair capabilities, can quickly replace aging atrophic cells, prolongs the cell division cycle, and promotes collagen and elastic fibers to be linearly arranged, so that the skin is densely repaired and restored to be young, and the freeze-dried wadding has the functions of resisting aging and fading fine wrinkles.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A repair type freeze-dried wadding comprises the following raw materials in percentage by mass: 86% of purified water, 2% of pullulan polysaccharide, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 5% of acacia gum extract and 5% of resveratrol.
Example 2
A repair type freeze-dried wadding comprises the following raw materials in percentage by mass: 86% of purified water, 3% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 4.5% of acacia gum extract and 4.5% of resveratrol.
Example 3
A repair type freeze-dried wadding comprises the following raw materials in percentage by mass: 86% of purified water, 5.0% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 3.5% of acacia gum extract and 3.5% of resveratrol.
Comparative example 1
A repair type freeze-dried wadding comprises the following raw materials in percentage by mass: 86% of purified water, 1% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 5.5% of acacia gum extract and 5.5% of resveratrol.
Comparative example 2
A repair type freeze-dried wadding comprises the following raw materials in percentage by mass: 86% of purified water, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 6% of acacia gum extract and 6% of resveratrol.
Comparative example 3
The child face beautifying and whitening essence and the facial skin nursing and repairing first-aid essence hyaluronic acid stock solution are purchased in the market (https:// detail.1688.com/offer/664392238216.htmlspm ═ a261y.7663282.10811813088311.4.6141153fkR90k & sk ═ design).
Examples of the experiments
Testing for improvement of skin wrinkles;
measuring no fine line change by using a microscope with a camera, wherein the test objects are 120 volunteers, 60 males and 60 females, the age is between 45 and 65 years, and the face has wrinkles;
dividing 120 volunteers into six groups of A group, B group, C group, D group, E group and F group, wherein each group comprises 20 persons (10 men and 10 women);
the test was performed under the supervision of a dermatologist, group a applied twice daily (morning and evening) to the face the lyophilized flock prepared according to example 1; group B twice daily (morning and evening) face application of the lyophilized floes prepared in example 2; group C twice daily (morning and evening) face application of the lyophilized floc prepared in example 3; group D twice daily (morning and evening) face application of the lyophilized batting prepared in comparative example 1; group E twice daily (morning and evening) face application of the lyophilized floc prepared in comparative example 2; f, applying the face twice a day (morning and evening) with the face whitening essence liquid level skin care repair first-aid essence hyaluronic acid stock solution purchased in the market;
after 49 days of continuous use, the repair rate of the facial fine wrinkles is measured, and the comparison result is shown in table 1;
TABLE 1
| Severe wrinkles | Moderate wrinkle | Fine wrinkles | |
| Example 1 | 54％ | 75％ | 100％ |
| Example 2 | 58％ | 77％ | 100％ |
| Example 3 | 55％ | 73％ | 100％ |
| Comparative example 1 | 47％ | 64％ | 93％ |
| Comparative example 2 | 45％ | 67％ | 91％ |
| Comparative example 3 | 34％ | 52％ | 83％ |
As can be seen from the above table, the wrinkle repair rate of the volunteers using the freeze-dried flocs of examples 1-5 was much higher than that of the volunteer of comparative example 3; wherein the repair rate of the severe wrinkles is ranked from high to low: example 2 > example 3 > example 1 > comparative example 2 > comparative example 3; the repair rate of moderate wrinkles is ranked from high to low: example 2 > example 1 > example 3 > comparative example 1 > comparative example 2 > comparative example 3; the repair rate of fine wrinkles is ranked from high to low: example 1 > example 3 > comparative example 1 > comparative example 2 > comparative example 3.
The above embodiments of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are contemplated herein. To be exhaustive. All obvious changes and modifications which are obvious to the technical scheme of the invention are covered by the protection scope of the invention.
Claims (7)
1. The utility model provides a repair type freeze-drying wadding which characterized in that: the freeze-dried wadding comprises the following raw materials in percentage by mass: 80-90% of purified water, 0.5-5.0% of pullulan, 0.1-0.5% of sodium hyaluronate, 0.1-0.5% of mannitol, 0.5-1% of trehalose, 2-5% of acacia gum extract and 2-5% of resveratrol.
2. The reconditioning type freeze-dried floccule according to claim 1, wherein the freeze-dried floccule comprises the following raw materials by mass percentage: 86% of purified water, 2% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 5% of acacia gum extract and 5% of resveratrol.
3. The reconditioning type freeze-dried floccule according to claim 1, wherein the freeze-dried floccule comprises the following raw materials by mass percentage: 86% of purified water, 3% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 4.5% of acacia gum extract and 4.5% of resveratrol.
4. The reconditioning type freeze-dried floccule according to claim 1, wherein the freeze-dried floccule comprises the following raw materials by mass percentage: 86% of purified water, 5.0% of pullulan, 0.5% of sodium hyaluronate, 0.5% of mannitol, 1% of trehalose, 3.5% of acacia gum extract and 3.5% of resveratrol.
5. The preparation method of the repairing type freeze-dried wadding is characterized by comprising the following steps:
step 1, weighing raw materials according to a formula ratio for subsequent use;
step 2, uniformly stirring pullulan, sodium hyaluronate, mannitol and trehalose to obtain an A-phase material, uniformly dissolving the A-phase material and purified water, filtering through a 200-mesh filter screen to obtain a filtered solution, and standing at normal temperature for later use;
step 3, uniformly stirring the Arabic gum extract and the resveratrol, filtering through a 200-mesh filter screen to obtain a B-phase material, and standing at normal temperature;
step 4, adding the solution obtained in the step 2 and the B-phase material into a stirring kettle, and uniformly stirring to obtain a semi-finished product;
step 5, filling, subpackaging and plugging the qualified semi-finished product, wherein the allowable filling tolerance is +1 ml;
and 6, putting the subpackaged semi-finished products into a freeze dryer for freeze drying to obtain the freeze-dried wadding.
6. The method for preparing the repairable freeze-dried floc according to claim 5, wherein the freeze-drying by the freeze-dryer comprises pre-freezing, refrigerating by a water catcher, primary drying and secondary drying.
7. The method according to claim 6, wherein the pre-freezing is performed at-45 ℃ for 120 minutes;
the set temperature of a cold well refrigerated by the water catcher is-45 ℃, the duration time is 10 minutes, then the pre-vacuum is 300Pa, the pre-vacuum time is 30 minutes, and the duration time is 30 minutes;
the primary drying comprises a first stage, a second stage and a third stage; the set temperature of the first stage is-20 ℃, the set time is 30 minutes, the duration time is 60 minutes, and the vacuum value is 30 Pa; the set temperature of the second stage is-10 ℃, the set time is 30 minutes, the duration time is 60 minutes, and the vacuum value is 30 Pa; the set temperature of the third stage is 0 ℃, the set time is 60 minutes, the duration time is 240 minutes, and the vacuum value is 30 Pa;
the secondary drying comprises a first stage, a second stage and a third stage; the set temperature of the first stage is 10 ℃, the set time is 60 minutes, the duration time is 120 minutes, and the vacuum value is 30 Pa; the set temperature of the second stage is 20 ℃, the set time is 60 minutes, the duration time is 120 ℃, and the vacuum value is 10 Pa; the third stage was set at 25 ℃ for 30 minutes with a duration of 180 minutes and a vacuum of 10 Pa.
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