CN114981287A - 阿里他汀相关化合物、经缀合阿里他汀化合物及其使用方法 - Google Patents

阿里他汀相关化合物、经缀合阿里他汀化合物及其使用方法 Download PDF

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CN114981287A
CN114981287A CN202180008396.2A CN202180008396A CN114981287A CN 114981287 A CN114981287 A CN 114981287A CN 202180008396 A CN202180008396 A CN 202180008396A CN 114981287 A CN114981287 A CN 114981287A
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S·施莱耶
B·A·门德尔松
P·查利塔-埃德
D·杰克逊
C·凯布尔
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Cytomx Therapeutics Inc
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    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN202180008396.2A 2020-01-06 2021-01-06 阿里他汀相关化合物、经缀合阿里他汀化合物及其使用方法 Pending CN114981287A (zh)

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Application Number Priority Date Filing Date Title
US202062957780P 2020-01-06 2020-01-06
US62/957,780 2020-01-06
PCT/US2021/012364 WO2021142029A1 (en) 2020-01-06 2021-01-06 Auristatin-related compounds, conjugated auristatin-related compounds, and methods of use thereof

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CN202180008260.1A Pending CN114929286A (zh) 2020-01-06 2021-01-06 抗slc34a2抗体、抗体药物缀合物及它们的使用方法

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CN (2) CN114981287A (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
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CN114929286A (zh) * 2020-01-06 2022-08-19 西托姆克斯治疗公司 抗slc34a2抗体、抗体药物缀合物及它们的使用方法

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JP2025512798A (ja) 2022-03-25 2025-04-22 サイトムエックス セラピューティクス,インク. 活性化可能な二重アンカー型マスク化分子及びその使用方法
WO2023192973A1 (en) 2022-04-01 2023-10-05 Cytomx Therapeutics, Inc. Activatable multispecific molecules and methods of use thereof
EP4504782A2 (en) 2022-04-01 2025-02-12 CytomX Therapeutics, Inc. Cd3-binding proteins and methods of use thereof
EP4565260A1 (en) 2022-08-01 2025-06-11 CytomX Therapeutics, Inc. Protease-cleavable moieties and methods of use thereof
AR130080A1 (es) 2022-08-01 2024-10-30 Cytomx Therapeutics Inc Restos escindibles por proteasas, y métodos de uso de los mismos
US20260015425A1 (en) 2022-08-01 2026-01-15 Cytomx Therapeutics, Inc. Protease-cleavable substrates and methods of use thereof
EP4565250A1 (en) 2022-08-01 2025-06-11 CytomX Therapeutics, Inc. Protease-cleavable substrates and methods of use thereof
US20260049148A1 (en) 2022-08-01 2026-02-19 Cytomx Therapeutics, Inc. Protease-cleavable moieties and methods of use thereof
WO2024216170A2 (en) 2023-04-12 2024-10-17 Cytomx Therapeutics, Inc. Activatable cytokine constructs and related compositions and methods
WO2024216194A1 (en) 2023-04-12 2024-10-17 Cytomx Therapeutics, Inc. Masking polypeptides, activatable cytokine constructs, and related compositions and methods
JP2026513839A (ja) 2023-04-12 2026-05-01 サイトムエックス セラピューティクス,インク. マスキングポリペプチド、活性化可能サイトカイン構成体、ならびに関連する組成物及び方法
WO2025131025A1 (en) * 2023-12-21 2025-06-26 Lanova Medicines Development Co., Ltd. Conjugates of anti-slc34a2 antibody and uses thereof
WO2025199352A2 (en) * 2024-03-20 2025-09-25 Juno Therapeutics, Inc. Antibodies specific for solute carrier family 34 member 2 (slc34a2)
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