CN114981264B - 脂肪酸酰胺衍生物 - Google Patents
脂肪酸酰胺衍生物 Download PDFInfo
- Publication number
- CN114981264B CN114981264B CN202080089588.6A CN202080089588A CN114981264B CN 114981264 B CN114981264 B CN 114981264B CN 202080089588 A CN202080089588 A CN 202080089588A CN 114981264 B CN114981264 B CN 114981264B
- Authority
- CN
- China
- Prior art keywords
- drug
- disorder
- alkyl
- compound
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019-232927 | 2019-12-24 | ||
| JP2019232927 | 2019-12-24 | ||
| PCT/JP2020/048117 WO2021132311A1 (ja) | 2019-12-24 | 2020-12-23 | 脂肪族酸アミド誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114981264A CN114981264A (zh) | 2022-08-30 |
| CN114981264B true CN114981264B (zh) | 2024-07-26 |
Family
ID=76574184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080089588.6A Active CN114981264B (zh) | 2019-12-24 | 2020-12-23 | 脂肪酸酰胺衍生物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US12503463B2 (https=) |
| EP (1) | EP4082616B1 (https=) |
| JP (1) | JP7662534B2 (https=) |
| KR (1) | KR20220120625A (https=) |
| CN (1) | CN114981264B (https=) |
| AU (1) | AU2020413284A1 (https=) |
| BR (1) | BR112022011844A2 (https=) |
| CA (1) | CA3161806A1 (https=) |
| ES (1) | ES3040677T3 (https=) |
| HU (1) | HUE072877T2 (https=) |
| MX (1) | MX2022007947A (https=) |
| PL (1) | PL4082616T3 (https=) |
| PT (1) | PT4082616T (https=) |
| WO (1) | WO2021132311A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220120625A (ko) * | 2019-12-24 | 2022-08-30 | 스미토모 파마 가부시키가이샤 | 지방족 산 아미드 유도체 |
| JP7655885B2 (ja) * | 2021-06-30 | 2025-04-02 | 住友ファーマ株式会社 | 脂肪族酸アミド誘導体を含有する医薬組成物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1139108A (zh) * | 1995-03-17 | 1997-01-01 | 赫彻斯特马里恩鲁斯公司 | 取代苯并噻吩基哌嗪、作为药物的用途及其制备方法 |
| CN101208314A (zh) * | 2005-04-26 | 2008-06-25 | 海普尼昂公司 | 苯并异唑哌嗪化合物及其使用方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880930A (en) | 1987-11-30 | 1989-11-14 | New James S | Psychotropic acyclic amide derivatives |
| US5880121A (en) * | 1996-01-05 | 1999-03-09 | Hoechst Marion Roussel Inc. | 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof |
| JP4497815B2 (ja) | 2001-02-16 | 2010-07-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 新規な複素環式アミド誘導体およびドーパミンｄ３受容体リガンドとしてのその使用 |
| FR2827287B1 (fr) * | 2001-07-13 | 2003-10-31 | Servier Lab | Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2006508101A (ja) | 2002-11-08 | 2006-03-09 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | フェニルアルキルおよびピリジルアルキルピペラジン誘導体 |
| PL392436A1 (pl) | 2010-09-17 | 2012-03-26 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Pochodne arylosulfonamidów do leczenia chorób odśrodkowego układu nerwowego |
| WO2014079155A1 (zh) * | 2012-11-26 | 2014-05-30 | 辽宁贝雷生物制药有限公司 | 苯并五元氮杂环基哌嗪或哌啶衍生物的用途 |
| KR20220120625A (ko) * | 2019-12-24 | 2022-08-30 | 스미토모 파마 가부시키가이샤 | 지방족 산 아미드 유도체 |
-
2020
- 2020-12-23 KR KR1020227025336A patent/KR20220120625A/ko active Pending
- 2020-12-23 PL PL20907330.3T patent/PL4082616T3/pl unknown
- 2020-12-23 CA CA3161806A patent/CA3161806A1/en active Pending
- 2020-12-23 JP JP2021567520A patent/JP7662534B2/ja active Active
- 2020-12-23 AU AU2020413284A patent/AU2020413284A1/en active Pending
- 2020-12-23 EP EP20907330.3A patent/EP4082616B1/en active Active
- 2020-12-23 MX MX2022007947A patent/MX2022007947A/es unknown
- 2020-12-23 US US17/612,099 patent/US12503463B2/en active Active
- 2020-12-23 HU HUE20907330A patent/HUE072877T2/hu unknown
- 2020-12-23 CN CN202080089588.6A patent/CN114981264B/zh active Active
- 2020-12-23 WO PCT/JP2020/048117 patent/WO2021132311A1/ja not_active Ceased
- 2020-12-23 PT PT209073303T patent/PT4082616T/pt unknown
- 2020-12-23 BR BR112022011844A patent/BR112022011844A2/pt unknown
- 2020-12-23 ES ES20907330T patent/ES3040677T3/es active Active
-
2021
- 2021-11-17 US US17/528,743 patent/US11339151B2/en active Active
-
2025
- 2025-11-18 US US19/392,712 patent/US20260078115A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1139108A (zh) * | 1995-03-17 | 1997-01-01 | 赫彻斯特马里恩鲁斯公司 | 取代苯并噻吩基哌嗪、作为药物的用途及其制备方法 |
| CN101208314A (zh) * | 2005-04-26 | 2008-06-25 | 海普尼昂公司 | 苯并异唑哌嗪化合物及其使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US12503463B2 (en) | 2025-12-23 |
| TW202136235A (zh) | 2021-10-01 |
| KR20220120625A (ko) | 2022-08-30 |
| CA3161806A1 (en) | 2021-07-01 |
| EP4082616A1 (en) | 2022-11-02 |
| US20220073506A1 (en) | 2022-03-10 |
| US20260078115A1 (en) | 2026-03-19 |
| JPWO2021132311A1 (https=) | 2021-07-01 |
| BR112022011844A2 (pt) | 2022-08-30 |
| WO2021132311A1 (ja) | 2021-07-01 |
| EP4082616B1 (en) | 2025-09-03 |
| US11339151B2 (en) | 2022-05-24 |
| JP7662534B2 (ja) | 2025-04-15 |
| CN114981264A (zh) | 2022-08-30 |
| PL4082616T3 (pl) | 2025-12-15 |
| MX2022007947A (es) | 2022-07-27 |
| EP4082616A4 (en) | 2024-01-03 |
| AU2020413284A1 (en) | 2022-08-18 |
| US20220213079A1 (en) | 2022-07-07 |
| PT4082616T (pt) | 2025-12-02 |
| HUE072877T2 (hu) | 2025-12-28 |
| ES3040677T3 (en) | 2025-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2020353984B2 (en) | 2-isoindol-1,3,4-oxadiazole derivatives useful as HDAC6 inhibitors | |
| JP4245483B2 (ja) | アデノシン調節薬としての２−アミノベンゾチアゾールの尿素 | |
| JP5502733B2 (ja) | ５−ｈｔ２ａ及びｄ３受容体の二重のモジュレーター | |
| CA2957046C (en) | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases | |
| BR112016008654B1 (pt) | Compostos bicíclicos contendo enxofre, composição farmacêutica compreendendo ditos compostos e uso terapêutico dos mesmos | |
| US20260078115A1 (en) | Aliphatic acid amide derivative | |
| BR112019015273A2 (pt) | compostos | |
| IL291774A (en) | Compounds active towards nuclear receptors | |
| JP2020506966A (ja) | 化合物 | |
| EP3148963A1 (en) | 1 -(cyclopent-2-en-1 -yl)-3-(2-hydroxy-3-(arylsulfonyl)phenyl)urea derivatives as cxcr2 inhibitors | |
| TWI860295B (zh) | 縮環內醯胺衍生物 | |
| RU2690154C2 (ru) | Производные морфолин-пиридина | |
| JP6370294B2 (ja) | 環状アミノメチルピリミジン誘導体 | |
| JP2020023570A (ja) | ２，６−ジ置換ピリジン誘導体 | |
| KR20150065190A (ko) | 피라진 유도체 | |
| JP7655885B2 (ja) | 脂肪族酸アミド誘導体を含有する医薬組成物 | |
| TWI917344B (zh) | 脂肪族酸醯胺衍生物 | |
| JP7511497B2 (ja) | 縮環ラクタム誘導体からなる医薬 | |
| JP2022541627A (ja) | 二環性ｃｘ３ｃｒ１受容体アゴニスト | |
| HK40079616B (en) | Aliphatic acid amide derivative | |
| HK40079616A (en) | Aliphatic acid amide derivative | |
| BR112020018767A2 (pt) | inibidores de secreção de proteínas à base de triazaciclododecansulfonamida (tcd) | |
| EA046822B1 (ru) | Производное амида алифатической кислоты | |
| JP2020050656A (ja) | ２，６−ジ置換ピリジン誘導体からなる医薬 | |
| JP2016108326A (ja) | 環状アミノメチルピリミジン誘導体からなる医薬 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |