CN114949066A - Composition for treating mosquito bites, preparation method and pharmaceutical application thereof - Google Patents
Composition for treating mosquito bites, preparation method and pharmaceutical application thereof Download PDFInfo
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Abstract
The invention provides a composition for treating mosquito bites, which is prepared from the following raw materials: patchouli, rhizoma atractylodis, cinnamon, schizonepeta, elsholtzia, folium artemisiae argyi, clove, pepper, mint and natural borneol. The composition for treating mosquito bites has a good treatment effect on mosquito bites, can relieve itching and pain, diminish inflammation, reduce swelling, prevent infection and prevent disease transmission, and has a mild formula without stimulating the skin. Moreover, the composition for treating mosquito bites is a traditional Chinese medicine component, and compared with chemical medicines, the composition has a good effect of treating mosquito bites and avoids side effects caused by the chemical medicines.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a composition for treating mosquito bites, a preparation method and a pharmaceutical application thereof.
Background
The bite of mosquitoes is a common and common phenomenon. Generally, symptoms such as redness, inflammation, itching, pain, etc. may appear after being bitten by mosquitoes. In addition, mosquito bites can also spread some diseases, and medicaments can be used for relieving itching and pain, diminishing inflammation, reducing swelling, preventing infection and preventing the spread of diseases.
Currently, the commonly used external medicines for treating mosquito bites are mostly chemical medicine products, and have certain side effects. Moreover, most of the drugs for treating mosquito bites contain alcohol, can irritate the skin and are not suitable for people with skin allergy. Therefore, there is a need to develop a drug for treating mosquito bites, which can relieve itching and pain, diminish inflammation, reduce swelling, prevent infection and prevent the spread of diseases, does not irritate the skin, and has few side effects.
Disclosure of Invention
In view of the deficiencies of the prior art, it is an object of the present invention to provide a composition for the treatment of mosquito bites.
In order to achieve the above object, the composition for treating mosquito bite of the present invention is prepared from the following raw materials:
4-14 parts of patchouli, 9-28 parts of rhizoma atractylodis, 0.5-4 parts of cinnamon, 1-5 parts of schizonepeta, 5-18 parts of elsholtzia, 11-33 parts of folium artemisiae argyi, 0.1-3 parts of clove, 0.5-2 parts of pepper and 2-10 parts of mint.
Preferably, the composition for treating mosquito bites according to the invention, wherein the raw material further comprises 0.01-0.2 parts by weight of natural borneol.
Patchouli has the effects of eliminating dampness with aromatics, dispelling summerheat and relieving exterior syndrome, rhizoma atractylodis has the effects of eliminating dampness and strengthening spleen, dispelling wind and cold, pepper has the effects of killing parasites and relieving itching, and the three monarch medicines are used together to kill parasites and remove dirt to relieve itching. The five ministerial drugs are combined to assist the efficacy of the monarch drug in killing parasites and relieving itching, and can also detoxify, stop bleeding and reduce swelling. The mint is pungent and cool, can reduce swelling, stop bleeding and treat insect injury, the natural borneol can clear heat and relieve pain, and the combination of the two adjuvant drugs can enhance the effects of reducing swelling, stopping bleeding and relieving pain and harmonize the property of warm and dry of monarch and minister drugs.
Further preferably, the composition for treating mosquito bites according to the invention is prepared from the following raw materials:
8-10 parts of patchouli, 18-20 parts of rhizoma atractylodis, 0.6-2.8 parts of cinnamon, 1.2-3.8 parts of schizonepeta, 10-12 parts of elsholtzia, 20-24 parts of folium artemisiae argyi, 0.4-2.5 parts of clove, 0.5-1.5 parts of pepper, 4-8 parts of mint and 0.01-0.15 part of natural borneol.
Preferably, the composition for treating mosquito bites further comprises a pharmaceutical adjuvant.
Preferably, the composition for treating mosquito bites further comprises 0.2-64 parts by weight of pharmaceutical excipients, preferably 8-46 parts by weight of pharmaceutical excipients, wherein the pharmaceutical excipients can be one or more of medium-chain triglyceride, castor oil, hemp seed oil, olive oil, soybean oil, corn oil, peanut oil, coconut oil, tea seed oil, grape seed oil, glycerol, beeswax, stearic acid, tween-80, lanolin, carbomer 980, hydroxypropyl-beta-cyclodextrin and palm wax, and preferably the medium-chain triglyceride is selected.
Preferably, the composition for treating mosquito bites of the present invention may be in the form of volatile oils, and thus, the present invention also provides volatile oils for treating mosquito bites.
Another object of the present invention is to provide a method for preparing a composition for treating mosquito bites, which can be prepared by a subcritical water extraction method, comprising the steps of:
crushing the pogostemon cablin, extracting the crushed pogostemon cablin in water for 30-40 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 140-160 ℃ to obtain pogostemon cablin volatile oil, wherein the water-material ratio is 15-20: 1(mL/g), the extraction rate of the pogostemon cablin volatile oil is 0.8-1.1%, the extraction pressure can be any pressure within the range of 5-10 Mpa, such as 5, 6, 7, 8, 9 or 10Mpa, the extraction temperature can be any temperature within the range of 140-160 ℃, such as 140, 145, 150, 155 or 160 ℃,
crushing rhizoma atractylodis, extracting the crushed rhizoma atractylodis in water for 50-60 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 150-170 ℃ to obtain rhizoma atractylodis volatile oil, wherein the water-material ratio is 15-18: 1(mL/g), the extraction rate of the rhizoma atractylodis volatile oil is 0.7-1.1%, the extraction pressure can be any pressure within the range of 5-10 Mpa, such as 5, 6, 7, 8, 9 or 10Mpa, the extraction temperature can be any temperature within the range of 150-170 ℃, such as 150, 155, 160, 165 or 170 ℃,
crushing cinnamon, extracting the crushed cinnamon in water for 40-50 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 150-160 ℃ to obtain cinnamon volatile oil, wherein the water-material ratio is 13-15: 1(mL/g), the extraction rate of the cinnamon volatile oil is 1.5-2.0%, the extraction pressure can be any pressure within the range of 5-10 Mpa, such as 5, 6, 7, 8, 9 or 10Mpa, the extraction temperature can be any temperature within the range of 150-160 ℃, such as 150, 155 or 160 ℃,
pulverizing herba schizonepetae, extracting the pulverized herba schizonepetae in water for 30-40 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 130-140 ℃ to obtain herba schizonepetae volatile oil, wherein the water-material ratio is 15-20: 1(mL/g), the extraction rate of the herba schizonepetae volatile oil is 0.7-0.9%, the extraction pressure can be any pressure within the range of 5-10 Mpa, such as 5, 6, 7, 8, 9 or 10Mpa, the extraction temperature can be any temperature within the range of 130-140 ℃, such as 130, 135 or 140 ℃,
pulverizing herba Moslae, extracting pulverized herba Moslae in water at extraction pressure of 5-10 Mpa and extraction temperature of 140-160 deg.C for 30-40 min to obtain herba Moslae volatile oil, wherein water-material ratio is 15-20: 1(mL/g), extraction rate of herba Moslae volatile oil is 0.8-1.1%, and extraction pressure can be any pressure within 5-10 Mpa, such as 5, 6, 7, 8, 9 or 10Mpa, extraction temperature can be any temperature within 140-160 deg.C, such as 140, 145, 150, 155 or 160 deg.C,
pulverizing folium artemisiae argyi, extracting the pulverized folium artemisiae argyi in water for 30-40 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 135-145 ℃ to obtain folium artemisiae argyi volatile oil, wherein the water-material ratio is 15-20: 1(mL/g), the extraction rate of the folium artemisiae argyi volatile oil is 0.5-0.7%, the extraction pressure can be any pressure within the range of 5-10 Mpa, such as 5, 6, 7, 8, 9 or 10Mpa, the extraction temperature can be any temperature within the range of 135-145 ℃, such as 135, 140 or 145 ℃,
pulverizing clove, extracting the pulverized clove in water at an extraction pressure of 5-10 MPa and an extraction temperature of 135-145 ℃ for 30-40 min to obtain clove volatile oil, wherein the water-material ratio is 15-18: 1(mL/g), the extraction rate of the clove volatile oil is 16-19%, the extraction pressure can be any pressure within the range of 5-10 MPa, such as 5, 6, 7, 8, 9 or 10MPa, the extraction temperature can be any temperature within the range of 135-145 ℃, such as 135, 140 or 145 ℃,
crushing the pepper, extracting the crushed pepper in water for 30-40 min under the extraction pressure of 5-10 MPa and the extraction temperature of 135-150 ℃ to obtain pepper volatile oil, wherein the water-material ratio is 15-18: 1(mL/g), the extraction rate of the pepper volatile oil is 4.0-5.0%, the extraction pressure can be any pressure within the range of 5-10 MPa, such as 5, 6, 7, 8, 9 or 10MPa, the extraction temperature can be any temperature within the range of 135-150 ℃, such as 135, 140, 145 or 150 ℃,
pulverizing mint, extracting the pulverized mint in water at an extraction pressure of 5-10 MPa and an extraction temperature of 135-145 ℃ for 30-40 min to obtain mint volatile oil, wherein the water-material ratio is 15-20: 1(mL/g), the extraction rate of the mint volatile oil is 0.8-1.0%, the extraction pressure can be any pressure within the range of 5-10 MPa, such as 5, 6, 7, 8, 9 or 10MPa, the extraction temperature can be any temperature within the range of 135-145 ℃, such as 135, 140 or 145 ℃,
mixing the volatile oils obtained from above raw materials.
Preferably, the preparation method of the composition for treating mosquito bites comprises the following steps:
pulverizing herba Agastaches, extracting pulverized herba Agastaches in water under 5Mpa and 150 deg.C for 30min to obtain herba Agastaches volatile oil,
pulverizing rhizoma Atractylodis, extracting pulverized rhizoma Atractylodis in water under 5Mpa and 160 deg.C for 60min to obtain rhizoma Atractylodis volatile oil,
pulverizing cortex Cinnamomi, extracting with water under 5Mpa and 160 deg.C for 40min to obtain cortex Cinnamomi volatile oil,
pulverizing herba Schizonepetae, extracting pulverized herba Schizonepetae in water under 5Mpa and 140 deg.C for 30min to obtain herba Schizonepetae volatile oil,
pulverizing herba Moslae, extracting with water under 5Mpa and 150 deg.C for 30min to obtain herba Moslae volatile oil,
pulverizing folium Artemisiae Argyi, extracting with water under 5Mpa and 135 deg.C for 30min to obtain folium Artemisiae Argyi volatile oil,
pulverizing flos Caryophylli, extracting with water under 5Mpa and 135 deg.C for 30min to obtain flos Caryophylli volatile oil,
pulverizing fructus Zanthoxyli, extracting pulverized fructus Zanthoxyli in water under 5Mpa and 140 deg.C for 40min to obtain fructus Zanthoxyli volatile oil,
pulverizing herba Menthae, extracting pulverized herba Menthae in water under 5Mpa at 135 deg.C for 30min to obtain herba Menthae volatile oil,
mixing the volatile oils obtained from above raw materials.
Preferably, natural borneol is added into the mixture of the volatile oil obtained from the raw materials, and the mixture is stirred to be completely dissolved.
Another object of the present invention is to provide a method for preparing a composition for treating mosquito bites, which can be prepared by a subcritical water extraction method, comprising the steps of:
pulverizing and mixing patchouli, rhizoma atractylodis, cinnamon, schizonepeta, elsholtzia, folium artemisiae argyi, clove, pepper and mint, and extracting the pulverized raw material mixture in water at an extraction pressure of 5-10 Mpa and an extraction temperature of 130-180 ℃ for 30-60 min to obtain the total volatile oil, wherein the water-material ratio of the raw material mixture to the water is 15-20: 1(ml/g), the extraction pressure can be any pressure within the range of 5-10 Mpa, such as 5, 6, 7, 8, 9 or 10Mpa, and the extraction temperature can be any temperature within the range of 130-180 ℃, such as 130, 135, 140, 145, 150, 155, 160, 165, 170, 175 or 180 ℃.
Preferably, natural borneol is added into the total volatile oil and stirred to be completely dissolved.
Still another object of the present invention is to provide the use of the above composition for the preparation of a medicament for the treatment of mosquito bites.
Preferably, the medicament for treating mosquito bites can be in the form of various preparations such as spray, aerosol, liniment, cream, ointment, gel, solution, smearing preparation and the like, so the invention also provides various preparations such as spray, aerosol, liniment, cream, ointment, gel, solution, smearing preparation and the like for treating mosquito bites.
Further, the spray, aerosol, liniment, cream, salve, ointment, gel, solution, and liniment for treating mosquito bites of the present invention can be obtained by a conventional method in the art. For example, the spray for treating mosquito bites of the present invention can be obtained by dispensing the above-mentioned composition of the present invention into spray bottles; the aerosol for treating mosquito bites can be obtained by subpackaging the composition into an aerosol aluminum can, pressing a cover, and filling nitrogen gas to ensure that the internal pressure is in the range of 0.8-1.0 Mpa; the liniment for treating mosquito bites can be obtained by subpackaging the composition into ball bottles.
In conclusion, the composition for treating mosquito bites, the volatile oil or the pharmaceutical preparation prepared from the volatile oil have good treatment effect on mosquito bites, can relieve itching and pain, diminish inflammation, reduce swelling, prevent infection and prevent disease transmission, and has mild formula without stimulating skin. Moreover, the composition for treating mosquito bites, the volatile oil or the pharmaceutical preparation prepared from the volatile oil are traditional Chinese medicine components, and compared with chemical medicines, the composition has a good effect of treating mosquito bites, and side effects caused by the chemical medicines are avoided.
Detailed description of the preferred embodiments
For a better understanding of the present invention, the following examples are set forth to illustrate, but are not to be construed as the limit of the present invention.
The source information of the various raw materials and reagents used in the examples of the present invention is as follows:
folium artemisiae argyi decoction pieces, batch number: 200301 Kunming dao Chinese medicine decoction piece factory
Mint decoction pieces, batch number: 200301 Kunming dao Chinese medicine decoction piece factory
Rhizoma atractylodis decoction pieces, batch number: 200301 Kunming dao Chinese medicine decoction piece factory
Clove decoction pieces, batch number: 200201 Kunming dao Chinese medicine decoction piece factory
Patchouli decoction pieces, batch number: 200201 Kunming dao Chinese medicine decoction piece factory
Herba elsholtziae decoction pieces, batch number: 1909001 Lingnan herbal decoction pieces Ltd
Natural borneol, batch No.: 202002003 Guangdong Huaqingyuan Biotech Co., Ltd
Cinnamon decoction pieces, batch number: DD20160201, department of Chinese medicine resources of Yunnan white drug group
Herba schizonepetae decoction pieces, batch number: YP20200401, department of Chinese medicine resources of Yunnan white drug powder group
The Chinese prickly ash is purchased by the market.
Examples
Example 1 preparation of a composition for the treatment of mosquito bites
1. Extraction of volatile oil
1.1 extraction of patchouli volatile oil
Pulverizing herba Agastaches, sieving with 20 mesh sieve, placing 400g herba Agastaches powder in subcritical water extractor, adding 6000mL water, extracting under 5Mpa and 150 deg.C for 30min, separating, and dehydrating to obtain herba Agastaches volatile oil with extraction rate of 0.95%.
1.2 extraction of Atractylodes lancea volatile oil
Taking rhizoma atractylodis medicinal material, crushing, sieving with a 20-mesh sieve, taking 900g of rhizoma atractylodis medicinal material powder, placing in a subcritical water extractor, adding 13500mL of water, extracting for 60min under the extraction pressure of 5Mpa and the extraction temperature of 160 ℃, separating, and dehydrating to obtain rhizoma atractylodis volatile oil, wherein the extraction rate is 1.01%.
1.3 cinnamon essential oil extraction
Taking cinnamon, crushing, sieving by a 20-mesh sieve, taking 60g of cinnamon powder, placing the cinnamon powder into a subcritical water extractor, adding 900mL of water, extracting for 50min under the extraction pressure of 5Mpa and the extraction temperature of 155 ℃, separating, and dehydrating to obtain cinnamon volatile oil, wherein the extraction rate is 1.65%.
1.4 extraction of Fineleaf Schizonepeta volatile oil
Taking herba schizonepetae, crushing, sieving with a 20-mesh sieve, taking 120g of herba schizonepetae powder, placing in a subcritical water extractor, adding 2100mL of water, extracting for 30min under the extraction pressure of 5Mpa and the extraction temperature of 135 ℃, separating, and dehydrating to obtain herba schizonepetae volatile oil, wherein the extraction rate is 0.87%.
1.5 Elsholtzia extract
Taking herba Moslae, pulverizing, sieving with 20 mesh sieve, taking 500g herba Moslae powder, placing in subcritical water extractor, adding 7500mL water, extracting at 150 deg.C under 5Mpa for 30min, separating, and dehydrating to obtain herba Moslae volatile oil with extraction rate of 0.95%.
1.6 extraction of volatile oil of Artemisia princeps Pampanini
Pulverizing folium Artemisiae Argyi, sieving with 20 mesh sieve, placing 1100g folium Artemisiae Argyi powder in subcritical water extractor, adding 16500mL water, extracting at 135 deg.C under 5Mpa for 30min, separating, and dehydrating to obtain folium Artemisiae Argyi volatile oil with extraction rate of 0.65%.
1.7 extraction of clove volatile oil
Pulverizing flos Caryophylli, sieving with 20 mesh sieve, placing 10g flos Caryophylli powder in subcritical water extractor, adding 180mL water, extracting at 135 deg.C under 5Mpa for 30min, separating, and dehydrating to obtain flos Caryophylli volatile oil with extraction rate of 17.5%.
1.8 extraction of essential oil of Zanthoxylum bungeanum
Taking a pepper medicinal material, crushing, sieving with a 20-mesh sieve, taking 50g of pepper medicinal material powder, placing in a subcritical water extractor, adding 750mL of water, extracting for 30min under the extraction pressure of 5Mpa and the extraction temperature of 140 ℃, separating, and dehydrating to obtain pepper volatile oil, wherein the extraction rate is 4.12%.
1.9 extraction of mint volatile oil
Pulverizing herba Menthae, sieving with 20 mesh sieve, placing 200g herba Menthae powder in subcritical water extractor, adding 3000mL water, extracting at 135 deg.C under 5Mpa for 30min, separating, and dehydrating to obtain herba Menthae volatile oil with extraction rate of 0.98%.
2. Preparation of main medicine mixture
And (2) uniformly mixing the volatile oil extracted in the step 1.1-1.9, adding 4g of natural borneol, and stirring to dissolve to obtain a main medicine mixture, namely the composition for treating mosquito bites.
Example 2 preparation of a composition for the treatment of mosquito bites
1. Extraction of volatile oil
1.1 extraction of the patchouli volatile oil
Pulverizing herba Agastaches, sieving with 20 mesh sieve, collecting herba Agastaches powder 800g, placing in subcritical water extractor, adding 16000mL water, extracting at 150 deg.C and 5Mpa for 30min, separating, and dehydrating to obtain herba Agastaches volatile oil with extraction rate of 0.98%.
1.2 extraction of Atractylodes lancea volatile oil
Taking rhizoma atractylodis medicinal material, crushing, sieving by a 20-mesh sieve, taking 1800g of rhizoma atractylodis medicinal material powder, placing the rhizoma atractylodis medicinal material powder into a subcritical water extractor, adding 32400mL of water, extracting for 60min under the extraction pressure of 5Mpa and the extraction temperature of 160 ℃, separating, dehydrating to obtain rhizoma atractylodis volatile oil, wherein the extraction rate is 0.95%.
1.3 cinnamon essential oil extraction
Taking cinnamon, crushing, sieving with a 20-mesh sieve, taking 150g of cinnamon powder, putting the cinnamon powder into a subcritical water extractor, adding 2250mL of water, extracting for 50min under the extraction pressure of 10Mpa and the extraction temperature of 160 ℃, separating, and dehydrating to obtain cinnamon volatile oil, wherein the extraction rate is 1.65%.
1.4 extraction of Fineleaf Schizonepeta volatile oil
Taking schizonepeta, crushing, sieving with a 20-mesh sieve, taking 300g of schizonepeta powder, placing in a subcritical water extractor, adding 6000mL of water, extracting for 40min under the extraction pressure of 10Mpa and the extraction temperature of 140 ℃, separating, and dehydrating to obtain schizonepeta volatile oil, wherein the extraction rate is 0.85%.
1.5 Elsholtzia extract
Taking herba Moslae medicinal material, pulverizing, sieving with 20 mesh sieve, taking herba Moslae medicinal material powder 1000g, placing in subcritical water extractor, adding 20000mL water, extracting at extraction pressure of 5Mpa and extraction temperature of 150 deg.C for 30min, separating, and dehydrating to obtain herba Moslae volatile oil with extraction rate of 0.90%.
1.6 extraction of volatile oil of Artemisia princeps Pampanini
Pulverizing folium Artemisiae Argyi, sieving with 20 mesh sieve, placing 2000g folium Artemisiae Argyi powder in subcritical water extractor, adding 40000mL water, extracting at 135 deg.C under 5Mpa for 30min, separating, and dehydrating to obtain folium Artemisiae Argyi volatile oil with extraction rate of 0.62%.
1.7 extraction of clove volatile oil
Pulverizing flos Caryophylli, sieving with 20 mesh sieve, placing 40g flos Caryophylli powder in subcritical water extractor, adding 720mL water, extracting at 135 deg.C under 5Mpa for 30min, separating, and dehydrating to obtain flos Caryophylli volatile oil with extraction rate of 16.8%.
1.8 extraction of essential oil of Zanthoxylum bungeanum
Taking a pepper medicinal material, crushing, sieving with a 20-mesh sieve, taking 120g of pepper medicinal material powder, placing in a subcritical water extractor, adding 1800mL of water, extracting for 40min under the extraction pressure of 10Mpa and the extraction temperature of 150 ℃, separating, and dehydrating to obtain pepper volatile oil, wherein the extraction rate is 4.07%.
1.9 extraction of mint volatile oil
Pulverizing herba Menthae, sieving with 20 mesh sieve, placing 400g herba Menthae powder in subcritical water extractor, adding 8000mL water, extracting at 135 deg.C under 5Mpa for 30min, separating, and dehydrating to obtain herba Menthae volatile oil with extraction rate of 0.95%.
2. Preparation of main medicine mixture
And (2) uniformly mixing the volatile oil extracted in the step 1.1-1.9, adding 1g of natural borneol, and stirring to dissolve to obtain a main medicine mixture, namely the composition for treating mosquito bites.
Example 3 preparation of a composition for the treatment of mosquito bites
1. Mixed volatile oil extraction
The preparation method comprises the following steps of respectively crushing nine medicinal materials of patchouli, rhizoma atractylodis, cinnamon, schizonepeta, elsholtzia, folium artemisiae argyi, clove, pepper and mint, sieving the medicinal materials with a 20-mesh sieve, respectively taking 200g of patchouli powder, 450g of rhizoma atractylodis powder, 40g of cinnamon powder, 75g of schizonepeta powder, 250g of elsholtzia powder, 500g of folium artemisiae argyi powder, 10g of clove powder, 30g of pepper powder and 100g of mint powder, placing the medicinal materials into a subcritical water extractor, adding 25000mL of water, extracting for 30min under the extraction pressure of 5Mpa and the extraction temperature of 135 ℃, separating and dehydrating to obtain mixed volatile oil.
2. Preparation of main medicine mixture
And (2) adding 1g of natural borneol into the mixed volatile oil extracted in the step (1), and stirring to dissolve the mixed volatile oil to obtain a main medicine mixture, namely the composition for treating mosquito bites.
EXAMPLE 4 preparation of spray
Adding 890g of medium-chain triglyceride or olive oil into the main medicine mixture prepared in the embodiment 1, complementing the volume to 1000mL, stirring to obtain clear liquid, and filling into a spray bottle with 10 mL/bottle to obtain the traditional Chinese medicine composition.
EXAMPLE 5 preparation of Aerosol
Adding 860g of medium-chain triglyceride or soybean oil into the main medicine mixture prepared in the embodiment 2, complementing the volume to 1000mL, stirring to obtain clear liquid, filling into an aerosol bottle, filling into the aerosol bottle with 10 mL/bottle, pressing a cover, and filling nitrogen to ensure that the internal pressure reaches 0.8-1.0 Mpa to obtain the aerosol.
EXAMPLE 6 preparation of the Liniment
Adding 900g of medium-chain triglyceride or corn oil into the main drug mixture prepared in example 3, complementing the volume to 1000mL, stirring to obtain clear liquid, and filling the clear liquid into a ball bottle with 10 mL/bottle.
EXAMPLE 7 preparation of cream
Preparing a main drug mixture according to the method of the embodiment 3, adding 10g of glycerol, 2g of stearic acid, 5g of medium-chain triglyceride or peanut oil and 1g of tween-80, stirring and dissolving on a water bath at 60 ℃, adding 40g of water, keeping the water bath at 60 ℃ while stirring, adding water, stirring for 30min, completely emulsifying, and cooling to room temperature to obtain the cream.
Example 8 ointment preparation
Preparing the main drug mixture according to the method of example 3, adding 200g of medium chain triglyceride or coconut oil, 30g of glycerol and 20g of beeswax, stirring and dissolving in water bath at 60 ℃, stirring for 30min, and cooling to room temperature to obtain the ointment.
EXAMPLE 9 preparation of sprays
Adding 900g of medium-chain triglyceride into the main medicine mixture prepared in the embodiment 1, complementing the volume to 1000mL, stirring to obtain clear liquid, and filling the clear liquid into a spray bottle with 10 mL/bottle to obtain the traditional Chinese medicine composition.
EXAMPLE 10 preparation of Aerosol
Adding 870g of medium-chain triglyceride or castor oil into the main medicine mixture prepared in the embodiment 2, complementing the volume to 1000mL, stirring to obtain clear liquid, filling into an aerosol bottle, capping with 10 mL/bottle, and filling nitrogen to ensure that the internal pressure reaches 0.8-1.0 Mpa to obtain the traditional Chinese medicine composition.
EXAMPLE 11 preparation of the Liniment
Adding 910g of medium-chain triglyceride or hemp seed oil to the main drug mixture prepared in example 3, supplementing the volume to 1000mL, stirring to obtain a clear liquid, and filling the clear liquid into a ball bottle with 10 mL/bottle.
EXAMPLE 12 preparation of the ointment
Preparing the main drug mixture according to the method of the embodiment 3, taking 800g of tea seed oil, adding 50g of palm wax, heating and stirring at 65 ℃ to completely dissolve the palm wax, adding the main drug mixture, stirring uniformly, and subpackaging to obtain the ointment.
EXAMPLE 13 preparation of gels
Preparing a main drug mixture according to the method of example 3, taking 10g of carbomer 980, adding 500ml of water to dissolve, refrigerating overnight to enable the carbomer to fully swell to obtain solution A; dissolving 100g of hydroxypropyl-beta-cyclodextrin in 500ml of water, stirring at 50 ℃, dripping the main medicine mixture, stirring to completely dissolve the main medicine mixture to obtain solution B, mixing the solution A and the solution B, adding triethanolamine to adjust the pH value to 4.5-8.5, and obtaining the gel.
EXAMPLE 14 preparation of solutions
The main drug mixture is prepared according to the method of the embodiment 3, 500g of tea seed oil is added, and the mixture is stirred evenly, so that the ointment is obtained, and when the ointment is used, a cotton swab or fingers are used for smearing on an affected part.
EXAMPLE 15 preparation of the spreading agent
Preparing the main drug mixture according to the method of example 3, weighing 200g of grape seed oil, adding 150g of lanolin and 100g of beeswax, stirring in a water bath at 65 ℃ to completely dissolve the beeswax, adding the main drug mixture, stirring uniformly, pouring the mixed solution into a lip balm mold while the mixed solution is hot, and cooling to obtain the rod-shaped smearing preparation. The coating agents with different shapes can also be obtained by using moulds with different shapes.
Experimental part
The inventor finds that the composition can be used for treating local pruritus, red swelling, inflammation and the like caused by mosquito bites. Experimental data are provided below to demonstrate that the composition of the present invention can be used to treat local itching, redness and swelling, inflammation, etc. caused by mosquito bites. By adopting a guinea pig skin itch model caused by histamine phosphate, a mouse writhing experiment caused by glacial acetic acid and a mouse auricle swelling model experiment caused by xylene, the pharmacodynamics research of the composition for mosquito bites is investigated from two aspects of relieving itching, resisting inflammation and reducing swelling.
The following experiment was performed using the composition for treating mosquito bites (hereinafter, referred to as the present composition) prepared in example 2 of the present invention.
1. Experiment of skin itch of guinea pig caused by histamine phosphate
1.1 Experimental methods
60 common-grade guinea pigs (purchased from Kunming commercial Biotechnology Co., Ltd., permitted production number of experimental animals: SCXK (Yunnan) K2018-0001) with weight of 250-300 g, half male and female, and 7 days after conventional feeding are randomly divided into 6 groups, 10 groups are respectively a model control group, a compound dexamethasone acetate cream (commercially available) group (50 mg/mouse), a low-dose (19mg/kg) group and a high-dose (38mg/kg) group of the composition, hair is shaved on the right hind instep of each guinea pig, and on the next day, the right hind instep of each guinea pig is smeared on the right hind instep of each guinea pig according to the corresponding dose and the dose is administered, the administration volume is 125 muL/kg, 3 days are continuously administered, and the model group is administered with physiological saline with the corresponding volume.
After 1h of the last administration, the shaved area of the right hind paw of the guinea pig was gently abraded with fine sandpaper to make it reddish but not bleed, and the area was 1cm 2 . The application is carried out once again, after 10min, a cotton swab is used for dipping normal saline to remove a test object, 50 mu L/body of 0.01% histamine phosphate is dripped on the wound surface, the concentration of 0.02%, 0.03% and 0.04% … is increased every 3min, 50 mu L/body of histamine phosphate is dripped on the wound surface every time, the itching relieving effect is evaluated by taking a threshold value of the itching of the guinea pig caused by the histamine phosphate (the itching threshold, namely the total amount of the histamine phosphate given when the guinea pig licks the wound surface) as an index until the guinea pig licks the back foot.
1.2 results of the experiment
TABLE 1 Effect of the compositions of the present invention on Histamine phosphate induced Guinea pig itch threshold
Note: in comparison to the model set, b P<0.01， c P<0.001。
the experimental results in table 1 show that: compared with the model group, the compound dexamethasone acetate cream 50 mg/dose group can obviously increase the itching threshold of the guinea pig in the dose groups of 19mg/kg and 38mg/kg of the compound dexamethasone acetate cream (P <0.01 or P < 0.001).
2. Glacial acetic acid induced mouse writhing experiment
2.1 Experimental methods
96 SPF-grade KM mice (purchased from Beijing Huafukang biotech GmbH, laboratory animal production license number: SCXK (Jing) 2019-. The animals were applied by abdominal smearing at 30. mu.L/mouse, and the blank group was given an equal volume of purified water 1 time/day for 3 consecutive days.
1h after the last administration, 0.6% glacial acetic acid is intraperitoneally injected at the administration volume of 10mL/kg, the writhing reaction frequency of the mouse within 15min is observed after 10min (based on the fact that the mouse has the symptoms of abdominal indent, trunk and hind limb stretch and hip uplift reaction), and the analgesic rate is calculated: the analgesic rate (%) (average number of twists in model group-average number of twists in administration group)/average number of twists in model group × 100%.
2.2 results of the experiment
Table 2. Effect of the compositions of the present invention on the frequency of writhing in glacial acetic acid-induced mice
Note: in comparison with the blank set, the results, * P<0.05， ** P<0.01
the experimental results in table 2 show that compared with the blank group, the number of writhing of the mice in the positive control dexamethasone group is obviously reduced (P is less than 0.05), and the writhing inhibition rate is 41.3%. Compared with a blank group, the times of writhing of mice in a dose group and a high dose group in the composition are obviously reduced (P is less than 0.05, P is less than 0.01), and the writhing inhibition rates are respectively 30.6% and 47.5%.
3. Experiment for mouse auricle swelling caused by xylene
3.1 Experimental methods
After completion of the acetic acid writhing test, the animals were kept overnight (during the course of the acetic acid writhing test, the abdomen of the mice was coated with the drug (30. mu.L/mouse) and the right ear was simultaneously coated with the drug (20. mu.L/mouse)). The following day, the right auricle of the animal was applied again, and 20. mu.L/mouse, that is, the right auricle was continuously administered for 4 days in the xylene-induced mouse auricle swelling experiment. Blank groups were given an equal volume of purified water. After the administration is finished, 0.03mL of dimethylbenzene is uniformly coated on the two sides of the right ear of each group of mice 1h later, and the left ear is not coated as a control. The mice were sacrificed by taking off the cervical vertebrae 1h after the inflammation, the same part of the ears was cut off in the same area by a puncher with the diameter of 7mm, the ears were weighed and the difference between the weights of the two ears was taken as the swelling degree (the swelling degree is right ear weight-left ear weight).
3.2 results of the experiment
TABLE 3 Effect of the compositions of the present invention on the swelling degree of auricles of mice with xylene-induced inflammation
Note: in comparison with the blank set, the results, * P<0.05， ** P<0.01。
the experimental results in Table 3 show that compared with the blank group, the positive control dexamethasone group which is continuously administered for 4 days obviously reduces the swelling degree of auricles of the mice with xylene-induced inflammation (P is less than 0.01). Compared with a blank group, the swelling degree of the auricle of the mice caused by dimethylbenzene is obviously reduced by the medium-dose and high-dose groups of the composition (P <0.05 and P < 0.01).
In conclusion, under the experimental conditions and the designed dosage, the composition can be used for relieving itching, resisting inflammation and diminishing swelling after mosquito bites.
Claims (9)
1. A composition for treating mosquito bites is characterized by being prepared from the following raw materials:
4-14 parts of patchouli, 9-28 parts of rhizoma atractylodis, 0.5-4 parts of cinnamon, 1-5 parts of schizonepeta, 5-18 parts of elsholtzia, 11-33 parts of folium artemisiae argyi, 0.1-3 parts of clove, 0.5-2 parts of pepper and 2-10 parts of mint.
2. The composition for treating mosquito bites according to claim 1, wherein the raw materials further comprise 0.01 to 0.2 parts by weight of natural borneol.
3. A process for the preparation of a composition for the treatment of mosquito bites as claimed in claim 1 or 2, characterized by being prepared by subcritical water extraction, comprising the steps of:
crushing the pogostemon cablin, extracting the crushed pogostemon cablin in water for 30-40 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 140-160 ℃ to obtain pogostemon cablin volatile oil,
crushing rhizoma atractylodis, extracting the crushed rhizoma atractylodis in water for 50-60 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 150-170 ℃ to obtain rhizoma atractylodis volatile oil,
crushing cinnamon, extracting the crushed cinnamon in water for 40-50 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 150-160 ℃ to obtain cinnamon volatile oil,
pulverizing herba schizonepetae, extracting the pulverized herba schizonepetae in water for 30-40 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 130-140 ℃ to obtain herba schizonepetae volatile oil,
pulverizing herba Moslae, extracting pulverized herba Moslae in water at extraction pressure of 5-10 Mpa and extraction temperature of 140-160 deg.C for 30-40 min to obtain herba Moslae volatile oil,
pulverizing folium Artemisiae Argyi, extracting pulverized folium Artemisiae Argyi in water under extraction pressure of 5-10 Mpa and extraction temperature of 135-145 deg.C for 30-40 min to obtain folium Artemisiae Argyi volatile oil,
pulverizing clove, extracting the pulverized clove in water for 30-40 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 135-145 ℃ to obtain clove volatile oil,
crushing the pepper, extracting the crushed pepper in water for 30-40 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 135-150 ℃ to obtain pepper volatile oil,
pulverizing mint, extracting the pulverized mint in water for 30-40 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 135-145 ℃ to obtain mint volatile oil,
mixing the volatile oils obtained from above raw materials.
4. The method according to claim 3, wherein the natural borneol is added to the mixture of the volatile oils obtained from the above raw materials, and the mixture is stirred to be completely dissolved.
5. A process for the preparation of a composition for the treatment of mosquito bites as claimed in claim 1 or 2, characterized by being prepared by subcritical water extraction, comprising the steps of:
pulverizing and mixing patchouli, rhizoma atractylodis, cinnamon, schizonepeta, elsholtzia, folium artemisiae argyi, clove, pepper and mint, and extracting the pulverized raw material mixture in water for 30-60 min under the extraction pressure of 5-10 Mpa and the extraction temperature of 130-180 ℃ to obtain the total volatile oil.
6. The method according to claim 5, wherein the total volatile oil is added with natural borneol and stirred to be completely dissolved.
7. Composition for the treatment of mosquito bites according to claim 1 or 2, characterized in that it is in the form of a volatile oil.
8. Use of a composition according to claim 1 or 2 in the manufacture of a medicament for the treatment of mosquito bites.
9. Use according to claim 8, characterized in that said medicament for the treatment of mosquito bites is in the form of a spray, aerosol, liniment, cream, salve, ointment, gel, solution, spread.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104274579A (en) * | 2014-09-24 | 2015-01-14 | 江苏奇力康皮肤药业有限公司 | Traditional Chinese medicine oil for preventing and controlling mosquito bite and preparation method of traditional Chinese medicine oil |
| CN108478677A (en) * | 2018-05-18 | 2018-09-04 | 王轲甫 | A kind of Chinese medicine composition of mosquito-repellent antipruritic |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104274579A (en) * | 2014-09-24 | 2015-01-14 | 江苏奇力康皮肤药业有限公司 | Traditional Chinese medicine oil for preventing and controlling mosquito bite and preparation method of traditional Chinese medicine oil |
| CN108478677A (en) * | 2018-05-18 | 2018-09-04 | 王轲甫 | A kind of Chinese medicine composition of mosquito-repellent antipruritic |
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| Title |
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| 飞天悬壶猫: "夏日必备避瘟防秽香囊，祛病又防蚊[内附制作方法]", 百度, pages 1 - 2 * |
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