CN114949001A - 孤独症谱系障碍的诊断和治疗 - Google Patents
孤独症谱系障碍的诊断和治疗 Download PDFInfo
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- CN114949001A CN114949001A CN202210623110.8A CN202210623110A CN114949001A CN 114949001 A CN114949001 A CN 114949001A CN 202210623110 A CN202210623110 A CN 202210623110A CN 114949001 A CN114949001 A CN 114949001A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7057—(Intracellular) signaling and trafficking pathways
- G01N2800/7066—Metabolic pathways
- G01N2800/7076—Amino acid metabolism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7057—(Intracellular) signaling and trafficking pathways
- G01N2800/7066—Metabolic pathways
- G01N2800/7085—Lipogenesis or lipolysis, e.g. fatty acid metabolism
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
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- Psychology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261694679P | 2012-08-29 | 2012-08-29 | |
| US61/694,679 | 2012-08-29 | ||
| CN201380056909.2A CN104768560A (zh) | 2012-08-29 | 2013-08-28 | 孤独症谱系障碍的诊断和治疗 |
| PCT/US2013/057148 WO2014036182A2 (en) | 2012-08-29 | 2013-08-28 | Diagnosis and treatment of autism spectrum disorder |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380056909.2A Division CN104768560A (zh) | 2012-08-29 | 2013-08-28 | 孤独症谱系障碍的诊断和治疗 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114949001A true CN114949001A (zh) | 2022-08-30 |
Family
ID=50184623
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210623110.8A Pending CN114949001A (zh) | 2012-08-29 | 2013-08-28 | 孤独症谱系障碍的诊断和治疗 |
| CN201380056909.2A Pending CN104768560A (zh) | 2012-08-29 | 2013-08-28 | 孤独症谱系障碍的诊断和治疗 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380056909.2A Pending CN104768560A (zh) | 2012-08-29 | 2013-08-28 | 孤独症谱系障碍的诊断和治疗 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10220089B2 (https=) |
| EP (1) | EP2890808A4 (https=) |
| JP (2) | JP6679309B2 (https=) |
| CN (2) | CN114949001A (https=) |
| AU (2) | AU2013308826B2 (https=) |
| CA (1) | CA2881656C (https=) |
| WO (1) | WO2014036182A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115482924A (zh) * | 2022-09-06 | 2022-12-16 | 浙江大学医学院附属儿童医院 | 孤独症谱系障碍儿童智力障碍诊断模型的建立方法及装置 |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| PH12013500224A1 (en) | 2010-08-04 | 2013-04-08 | Borody Thomas J | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
| MX2013010343A (es) | 2011-03-09 | 2014-04-30 | Univ Minnesota | Composicion y metodos para el transplante de microbiota de colon. |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| US10039777B2 (en) | 2012-03-20 | 2018-08-07 | Neuro-Lm Sas | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| WO2013176774A1 (en) | 2012-05-25 | 2013-11-28 | Arizona Board Of Regents | Microbiome markers and therapies for autism spectrum disorders |
| WO2014036182A2 (en) * | 2012-08-29 | 2014-03-06 | California Institute Of Technology | Diagnosis and treatment of autism spectrum disorder |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| US10060932B2 (en) * | 2013-07-09 | 2018-08-28 | Stemina Biomarker Discovery, Inc. | Biomarkers of autism spectrum disorder |
| US20150294081A1 (en) | 2014-04-11 | 2015-10-15 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| US9176113B1 (en) | 2014-04-11 | 2015-11-03 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| US9758839B2 (en) | 2014-10-21 | 2017-09-12 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome functional features |
| AU2015335907A1 (en) | 2014-10-21 | 2017-04-13 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics |
| US10265009B2 (en) | 2014-10-21 | 2019-04-23 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features |
| WO2016069792A1 (en) * | 2014-10-30 | 2016-05-06 | California Institute Of Technology | Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders |
| EA201790811A1 (ru) * | 2014-10-30 | 2017-11-30 | Калифорния Инститьют Оф Текнолоджи | Содержащие бактерии композиции и способы для улучшения видов поведения при нарушениях неврологического развития |
| WO2016069801A1 (en) | 2014-10-30 | 2016-05-06 | California Institute Of Technology | Compositions and methods comprising bacteria for improving behavior in neurodecelopmental disorders |
| SG11201704814SA (en) | 2014-12-23 | 2017-07-28 | 4D Pharma Res Ltd | Pirin polypeptide and immune modulation |
| WO2016102950A1 (en) | 2014-12-23 | 2016-06-30 | 4D Pharma Research Limited | Immune modulation |
| JP6611156B2 (ja) * | 2015-01-30 | 2019-11-27 | 史郎 栃谷 | 妊娠期母体腸内細菌攪乱による行動異常モデル動物の作製方法とその用途 |
| US10525020B2 (en) | 2015-02-11 | 2020-01-07 | Laboratory Corporation Of America Holdings | Metabolic markers of attention deficit hyperactivity disorder |
| EP3268354B1 (en) | 2015-03-13 | 2020-05-06 | Mironova Innovations, LLC | Nalpha, nalpha, nalpha-trialkyl histidine derivatives useful for the preparation of ergothioneine compounds |
| WO2016168354A1 (en) * | 2015-04-13 | 2016-10-20 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome functional features |
| CN107709576B (zh) * | 2015-04-13 | 2022-06-03 | 普梭梅根公司 | 用于神经系统健康问题的微生物组来源的诊断和治疗的方法及系统 |
| CN107708716B (zh) * | 2015-04-13 | 2022-12-06 | 普梭梅根公司 | 用于微生物组分类学特征相关的状况的微生物组来源的诊断和治疗的方法及系统 |
| CA2985827A1 (en) | 2015-05-14 | 2016-11-17 | Crestovo Holdings Llc | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
| AU2016268158B2 (en) * | 2015-05-22 | 2022-03-17 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| ME03511B (me) | 2015-06-15 | 2020-04-20 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| HRP20191949T1 (hr) | 2015-06-15 | 2020-01-24 | 4D Pharma Research Limited | Blautia stercosis i wexlerae za upotrebu u liječenju upalnih i autoimunih bolesti |
| WO2016203221A1 (en) | 2015-06-15 | 2016-12-22 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| CN105213433A (zh) * | 2015-11-06 | 2016-01-06 | 王益超 | 一种用于治疗孤独症、复发性流产和不孕症的组合物 |
| HK1254843B (zh) | 2015-11-20 | 2020-04-17 | 希杰生物科技株式会社 | 包含细菌菌株的组合物 |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| CN105543369B (zh) * | 2016-01-13 | 2020-07-14 | 金锋 | 精神障碍的生物标志物及其应用 |
| SG10201913557TA (en) | 2016-03-04 | 2020-02-27 | 4D Pharma Plc | Compositions comprising bacterial blautia strains for treating visceral hypersensitivity |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| WO2017197252A1 (en) * | 2016-05-13 | 2017-11-16 | Stemina Biomarker Discovery, Inc. | Autism subsets |
| EP4707410A3 (en) | 2016-05-23 | 2026-03-25 | California Institute of Technology | Regulate gut microbiota to treat neurodegenerative disorders |
| US20170360848A1 (en) | 2016-06-15 | 2017-12-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| US10849936B2 (en) | 2016-07-01 | 2020-12-01 | Regents Of The University Of Minnesota | Compositions and methods for C. difficile treatment |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商4D製藥有限公司 | 包含細菌菌株之組合物 |
| US20180036352A1 (en) | 2016-08-03 | 2018-02-08 | Crestovo Holdings Llc | Methods for treating ulcerative colitis |
| AU2017325986B2 (en) * | 2016-09-16 | 2023-12-14 | Takeda Pharmaceutical Company Limited | Metabolite biomarkers for diseases associated with the contact activation system |
| WO2018071537A1 (en) | 2016-10-11 | 2018-04-19 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| US10092601B2 (en) | 2016-10-11 | 2018-10-09 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| US11213549B2 (en) | 2016-10-11 | 2022-01-04 | Finch Therapeutics Holdings Llc | Compositions and method for treating primary sclerosing cholangitis and related disorders |
| WO2018089794A1 (en) * | 2016-11-11 | 2018-05-17 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions for changing metabolite levels in a subject |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| US20180168196A1 (en) * | 2016-12-15 | 2018-06-21 | Nestec Sa | Compositions and methods that modulate bacteria in a companion animal |
| US20200023018A1 (en) * | 2017-02-07 | 2020-01-23 | California Institute Of Technology | Modulation of gut microbiota in huntington's disease and rett syndrome |
| CA3053245A1 (en) * | 2017-02-09 | 2018-08-16 | Cognoa, Inc. | Platform and system for digital personalized medicine |
| US11224624B2 (en) | 2017-02-14 | 2022-01-18 | California Institute Of Technology | Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease |
| JP6978122B2 (ja) * | 2017-03-31 | 2021-12-08 | アキシャル セラピューティクス,インク. | 自閉症および関連障害の治療および予防のための腸管選択的隔離剤 |
| WO2018187464A1 (en) | 2017-04-05 | 2018-10-11 | Crestovo Holdings Llc | Compositions and methods for treating diverticulitis and related disorders |
| CN110831606A (zh) | 2017-04-05 | 2020-02-21 | 克雷斯顿沃控股公司 | 治疗帕金森氏病(pd)和相关疾病的组合物和方法 |
| WO2018213204A1 (en) | 2017-05-15 | 2018-11-22 | Axial Biotherapeutics, Inc. | Inhibitors of microbially induced amyloid |
| ES2877726T3 (es) | 2017-05-22 | 2021-11-17 | 4D Pharma Res Ltd | Composiciones que comprenden cepas bacterianas |
| EP3630942B1 (en) | 2017-05-24 | 2022-11-30 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| JP2020521760A (ja) | 2017-05-26 | 2020-07-27 | クレストヴォ・ホールディングス・エルエルシー | 糞便微生物ベースの治療剤を含む凍結乾燥組成物ならびにそれを製造および使用する方法 |
| WO2018216912A1 (ko) * | 2017-05-26 | 2018-11-29 | 주식회사 엠디헬스케어 | 세균 메타게놈 분석을 통한 자폐증 진단방법 |
| ES2841902T3 (es) | 2017-06-14 | 2021-07-12 | 4D Pharma Res Ltd | Composiciones que comprenden cepas bacterianas |
| TWI812624B (zh) | 2017-06-14 | 2023-08-21 | 南韓商希杰生物科技股份有限公司 | 包含細菌品系之組成物 |
| PL3600363T3 (pl) | 2017-06-14 | 2021-06-14 | 4D Pharma Research Limited | Kompozycje zawierające szczepy bakteryjne |
| US10939862B2 (en) * | 2017-07-05 | 2021-03-09 | Yusuf Ozgur Cakmak | System for monitoring auditory startle response |
| US11141089B2 (en) * | 2017-07-05 | 2021-10-12 | Yusuf Ozgur Cakmak | System for monitoring auditory startle response |
| US11883155B2 (en) | 2017-07-05 | 2024-01-30 | Yusuf Ozgur Cakmak | System for monitoring auditory startle response |
| EP3655544A4 (en) | 2017-07-17 | 2021-08-11 | Smartdna Pty Ltd | METHOD OF DIAGNOSING DYSBIOSIS |
| WO2019032573A1 (en) | 2017-08-07 | 2019-02-14 | Finch Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR MAINTAINING AND RESTORING A HEALTHY INTESTINAL BARRIER |
| WO2019136214A1 (en) * | 2018-01-05 | 2019-07-11 | California Institute Of Technology | Probiotics, metabolites, and uses thereof |
| EP3768287A2 (en) | 2018-03-22 | 2021-01-27 | Adare Pharmaceuticals SAS | New use of microbiological compositions |
| EP3818529A2 (en) * | 2018-07-08 | 2021-05-12 | Yeda Research and Development Co. Ltd | Person-specific assessment of probiotics responsiveness |
| US11166990B2 (en) | 2018-07-13 | 2021-11-09 | Finch Therapeutics Holdings Llc | Methods and compositions for treating ulcerative colitis |
| CN109142744A (zh) * | 2018-07-26 | 2019-01-04 | 珠海中科先进技术研究院有限公司 | 一种自闭症谱系障碍诊断试剂盒 |
| US11911419B2 (en) | 2018-09-27 | 2024-02-27 | Finch Therapeutics Holdings Llc | Compositions and methods for treating epilepsy and related disorders |
| WO2020094748A1 (en) | 2018-11-06 | 2020-05-14 | Stalicla Sa | Metabolic profiling for the diagnosis of a subset of idiopathic autism spectrum disorder patients, asd phenotype 1 |
| US11676719B2 (en) * | 2018-12-20 | 2023-06-13 | Oregon Health & Science University | Subtyping heterogeneous disorders using functional random forest models |
| CN109706235A (zh) * | 2019-01-29 | 2019-05-03 | 广州康昕瑞基因健康科技有限公司 | 一种肠道微生物菌群的检测和分析方法及其系统 |
| WO2020206444A1 (en) | 2019-04-05 | 2020-10-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Diagnostic for childhood risk of autism spectrum disorder |
| EP3948277A4 (en) * | 2019-04-05 | 2023-05-24 | Arizona Board of Regents on behalf of Arizona State University | METABOLITES AS DIAGNOSTICS OF AUTISTIC SPECTRUM DISEASE IN CHILDREN WITH GASTROINTESTINAL SYMPTOMS |
| CN113906296B (zh) * | 2019-04-23 | 2024-11-15 | 中国医学科学院北京协和医院 | 基于机器学习的使用代谢物作为标记物的孤独症谱系障碍诊断方法和装置 |
| EP3965820A4 (en) * | 2019-05-07 | 2023-02-08 | The Regents of the University of California | COMPOSITIONS AND METHODS TO PROMOTE HEALTHY NEURAL DEVELOPMENT IN AN UNBORN BABY |
| CN110178787B (zh) * | 2019-05-08 | 2022-03-22 | 河南中医药大学 | 一种运用粪菌移植法建立自闭症大鼠模型的方法 |
| US12290538B2 (en) | 2019-07-19 | 2025-05-06 | Finch Therapeutics Holdings Llc | Methods and products for treatment of gastrointestinal disorders |
| EP4041265A4 (en) * | 2019-10-11 | 2024-03-27 | Stemina Biomarker Discovery, Inc. | DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS ASSOCIATED WITH ALTERED LEVELS OF METABOLITES CONCENTRATIONS |
| WO2021079869A1 (ja) | 2019-10-21 | 2021-04-29 | ビオフェルミン製薬株式会社 | 尿毒素軽減剤 |
| WO2021081247A1 (en) * | 2019-10-22 | 2021-04-29 | Cornell University | Microbiota based therapies to promote mental health |
| CN114829629A (zh) * | 2019-12-19 | 2022-07-29 | 希尔氏宠物营养品公司 | 治疗和降低患上与犬科动物的升高的4-乙基苯基硫酸盐相关的病状的风险的组合物和方法以及鉴定有风险患上此类病状的犬科动物的方法 |
| WO2021178945A1 (en) * | 2020-03-06 | 2021-09-10 | University Of Virginia Patent Foundation | System and method for predicting risk of diagnosis for autism spectrum disorder using neonatal analytics |
| CN111455076B (zh) * | 2020-04-17 | 2022-10-21 | 济南市儿童医院 | 用于儿童孤独症评估的口腔菌群微生物 |
| CN116547520A (zh) * | 2020-09-21 | 2023-08-04 | 分子优公司 | 孤独症谱系障碍的诊断与治疗方法 |
| WO2022056646A1 (en) * | 2020-09-21 | 2022-03-24 | Molecular You Corporation | Method of diagnosis and treatment of autism spectrum disorder |
| AU2021367318A1 (en) * | 2020-10-19 | 2023-06-08 | Oregon State University | Methods for treating autism spectrum disorder |
| CN114544826B (zh) * | 2020-11-24 | 2023-12-08 | 重庆医科大学 | 检测血浆中组氨酸的试剂在制备抑郁症检测试剂盒中的用途 |
| EP4012414A1 (en) | 2020-12-11 | 2022-06-15 | Stalicla S.A. | Diagnosis of autism spectrum disorder phenotype 1 |
| CN113069469B (zh) * | 2021-04-07 | 2022-12-13 | 上海市精神卫生中心(上海市心理咨询培训中心) | 调节性t细胞在制备治疗孤独症药物或细胞疗法中的应用 |
| CN114699424B (zh) * | 2022-02-16 | 2023-07-18 | 广州知易生物科技有限公司 | 脆弱拟杆菌两性离子荚膜多糖或/和改性的两性离子荚膜多糖的新应用 |
| CN114699423B (zh) * | 2022-02-16 | 2023-06-23 | 广州知易生物科技有限公司 | 脆弱拟杆菌的荚膜多糖提取物在制备防治精神分裂症的药物中的应用 |
| CN114457153A (zh) * | 2022-03-15 | 2022-05-10 | 西安交通大学 | 一种孤独症血清神经元来源外泌体标志物chrm1的应用 |
| CN117598247B (zh) * | 2022-03-25 | 2026-02-10 | 天津中医药大学 | 咪唑丙酸在制备用于诱导溃疡性结肠炎动物模型的造模剂中的应用 |
| CN114622026B (zh) * | 2022-04-02 | 2024-10-01 | 中南大学湘雅三医院 | 拟杆菌作为预测自闭症疗效的客观指标 |
| CN116990395A (zh) * | 2022-04-26 | 2023-11-03 | 中国科学院深圳先进技术研究院 | 一种基于粪便的阿尔兹海默症生物标志物及其应用 |
| CN115368300B (zh) * | 2022-10-27 | 2023-03-24 | 北京拓领博泰生物科技有限公司 | 用于tlr8抑制剂的化合物及其制备方法、应用 |
| CN115616227B (zh) * | 2022-11-18 | 2023-05-16 | 四川大学华西医院 | 吲哚-3-丙烯酰甘氨酸检测试剂的用途、诊断或辅助诊断慢性阻塞性肺病的试剂盒及系统 |
| US12005044B1 (en) | 2022-11-29 | 2024-06-11 | Autism Therapeutics Inc. | Treatment of autism spectrum disorders with ergothioneine, selenoneine, or combinations thereof |
| WO2025007066A1 (en) * | 2023-06-30 | 2025-01-02 | University Of Massachusetts | Biomarkers and methods related to fragile x syndrome |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120087895A1 (en) * | 2010-10-07 | 2012-04-12 | Mazmanian Sarkis K | Probiotic Therapies for Autism |
| US20120207726A1 (en) * | 2009-06-16 | 2012-08-16 | The Trustees Of Columbia University In The City Of New York | Autism-associated biomarkers and uses thereof |
| US20170192019A1 (en) * | 2010-04-29 | 2017-07-06 | Wisconsin Alumni Research Foundation | Metabolic Biomarkers of Autism |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5443826A (en) | 1988-08-02 | 1995-08-22 | Borody; Thomas J. | Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli |
| AUPM864894A0 (en) | 1994-10-07 | 1994-11-03 | Borody, Thomas Julius | Treatment of bowel-dependent neurological disorders |
| US5951977A (en) | 1997-10-14 | 1999-09-14 | The United States Of America, As Represented By The Secretary Of Agriculture | Competitive exclusion culture for swine |
| US20020013270A1 (en) | 2000-06-05 | 2002-01-31 | Bolte Ellen R. | Method for treating a mental disorder |
| US20040170617A1 (en) | 2000-06-05 | 2004-09-02 | Finegold Sydney M. | Method of treating diseases associated with abnormal gastrointestinal flora |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| US20040005304A1 (en) | 2002-07-08 | 2004-01-08 | Mak Wood, Inc. | Novel compositions and methods for treating neurological disorders and associated gastrointestinal conditions |
| US7749509B2 (en) | 2003-08-29 | 2010-07-06 | Cobb And Company, Llp | Treatment of autism using probiotic composition |
| US7731976B2 (en) | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
| US20060177424A1 (en) | 2003-08-29 | 2006-08-10 | Cobb Mark L | Treatment of disease states and adverse physiological conditions utilizing anti-fungal compositions |
| US8192733B2 (en) | 2003-08-29 | 2012-06-05 | Cobb & Associates | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| US20060167057A1 (en) | 2004-11-16 | 2006-07-27 | Xianqi Kong | Compounds for the treatment of CNS and amyloid associated diseases |
| GB0504096D0 (en) | 2005-02-28 | 2005-04-06 | Tipogen As | Method |
| US20100233312A9 (en) | 2005-04-11 | 2010-09-16 | The Procter & Gamble Company | Compositions comprising probiotic and sweetener components |
| AU2008317000B2 (en) | 2007-10-26 | 2014-10-23 | Brenda E. Moore | Probiotic compositions and methods for inducing and supporting weight loss |
| WO2009061744A2 (en) | 2007-11-06 | 2009-05-14 | Edison Pharmaceuticals, Inc. | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| US20110118135A1 (en) | 2008-01-09 | 2011-05-19 | State Matthew W | Mutations in Contaction Associated Protein 2 (CNTNAP2) are Associated with Increased Risk for Ideopathic Autism |
| US20110294794A1 (en) | 2008-11-13 | 2011-12-01 | Link Medicine Corporation | Treatment of proteinopathies using a farnesyl transferase inhibitor |
| US20120190566A1 (en) | 2009-03-25 | 2012-07-26 | Susan Lindquist | Compositions and methods for inhibiting biofilms |
| US20110081320A1 (en) * | 2009-10-06 | 2011-04-07 | Nubiome, Inc. | Treatment/Cure of Autoimmune Disease |
| EP2485744A4 (en) | 2009-10-09 | 2014-01-22 | Prothera Inc | COMPOSITIONS AND METHODS COMPRISING THE PEDIOCOCCUS TO REDUCE AT LEAST ONE SYMPTOM ASSOCIATED WITH DEVELOPMENT-INVASIVE DISORDER IN A PERSON IN WHICH A DEVELOPMENT-INVASIVE DISORDER HAS BEEN DIAGNOSED |
| US9707207B2 (en) | 2010-05-26 | 2017-07-18 | The United States Of America As Represented By The Department Of Veterans Affairs | Method for diagnosing, preventing, and treating neurological diseases |
| AU2011261528A1 (en) | 2010-06-01 | 2013-01-10 | Moore Research Enterprises Llc | Cellular constituents from Bacteroides, compositions thereof, and therapeutic methods employing Bacteroides or cellular constituents thereof |
| EP2590658A2 (en) | 2010-07-08 | 2013-05-15 | Katholieke Universiteit Leuven | Compositions and methods for removal or destruction of amyloid fibril or amyloid adhesin comprising aggregates |
| US20120237482A1 (en) | 2011-03-18 | 2012-09-20 | Juan Rodriguez | Methods for treatment of neurological disorders by modulation of microglial activation |
| CN116942833A (zh) | 2011-12-01 | 2023-10-27 | 国立大学法人 东京大学 | 诱导调节性t细胞的增殖或积累的人源细菌 |
| WO2013154725A1 (en) | 2012-04-13 | 2013-10-17 | Trustees Of Boston College | Prebiotic compositions and methods of use |
| WO2014036182A2 (en) | 2012-08-29 | 2014-03-06 | California Institute Of Technology | Diagnosis and treatment of autism spectrum disorder |
| CA2899925A1 (en) | 2013-02-04 | 2014-08-07 | Seres Therapeutics, Inc. | Compositions and methods for inhibition of pathogenic bacterial growth |
| HK1218560A1 (zh) | 2013-02-04 | 2017-02-24 | Seres Therapeutics, Inc. | 组成与方法 |
| US9511100B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| FI127671B (en) | 2014-05-28 | 2018-11-30 | Filip Scheperjans | Method for diagnostics of Parkinson’s disease |
| CN104546932A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 卵形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| EA201790811A1 (ru) | 2014-10-30 | 2017-11-30 | Калифорния Инститьют Оф Текнолоджи | Содержащие бактерии композиции и способы для улучшения видов поведения при нарушениях неврологического развития |
| WO2016069792A1 (en) | 2014-10-30 | 2016-05-06 | California Institute Of Technology | Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders |
| WO2016069801A1 (en) | 2014-10-30 | 2016-05-06 | California Institute Of Technology | Compositions and methods comprising bacteria for improving behavior in neurodecelopmental disorders |
| US20170360853A1 (en) | 2015-01-07 | 2017-12-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Gastro-Intestinal Biomarkers for Diagnosis and Therapies of Proteinopathies |
| AU2016268158B2 (en) | 2015-05-22 | 2022-03-17 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| EP4707410A3 (en) | 2016-05-23 | 2026-03-25 | California Institute of Technology | Regulate gut microbiota to treat neurodegenerative disorders |
| WO2017220708A1 (en) | 2016-06-22 | 2017-12-28 | Prodigest Bvba | Microbial carotenoids affecting gut microbial composition |
-
2013
- 2013-08-28 WO PCT/US2013/057148 patent/WO2014036182A2/en not_active Ceased
- 2013-08-28 EP EP13832132.8A patent/EP2890808A4/en active Pending
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-
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- 2019-07-18 AU AU2019206081A patent/AU2019206081B2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120207726A1 (en) * | 2009-06-16 | 2012-08-16 | The Trustees Of Columbia University In The City Of New York | Autism-associated biomarkers and uses thereof |
| US20170192019A1 (en) * | 2010-04-29 | 2017-07-06 | Wisconsin Alumni Research Foundation | Metabolic Biomarkers of Autism |
| US20120087895A1 (en) * | 2010-10-07 | 2012-04-12 | Mazmanian Sarkis K | Probiotic Therapies for Autism |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115482924A (zh) * | 2022-09-06 | 2022-12-16 | 浙江大学医学院附属儿童医院 | 孤独症谱系障碍儿童智力障碍诊断模型的建立方法及装置 |
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