CN114929685A - 稠合吡啶环衍生物、其制备方法及其在医药上的应用 - Google Patents

稠合吡啶环衍生物、其制备方法及其在医药上的应用 Download PDF

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Publication number
CN114929685A
CN114929685A CN202080079266.3A CN202080079266A CN114929685A CN 114929685 A CN114929685 A CN 114929685A CN 202080079266 A CN202080079266 A CN 202080079266A CN 114929685 A CN114929685 A CN 114929685A
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China
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compound
pharmaceutically acceptable
group
acceptable salt
cycloalkyl
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CN202080079266.3A
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CN114929685B (zh
Inventor
张晓敏
胡伟民
贺峰
叶超百慧
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

一种通式(I)所示的稠合吡啶环衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂，特别是在制备用于预防和/或治疗HIV感染的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN202080079266.3A 2019-11-29 2020-11-27 稠合吡啶环衍生物、其制备方法及其在医药上的应用 Active CN114929685B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN201911198968 2019-11-29
CN2019111989689 2019-11-29
CN2020101040957 2020-02-20
CN202010104095 2020-02-20
CN202010500013 2020-06-04
CN2020105000130 2020-06-04
CN2020106560093 2020-07-09
CN202010656009 2020-07-09
PCT/CN2020/132026 WO2021104413A1 (zh) 2019-11-29 2020-11-27 稠合吡啶环衍生物、其制备方法及其在医药上的应用

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CN114929685A true CN114929685A (zh) 2022-08-19
CN114929685B CN114929685B (zh) 2023-12-12

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US (1) US20230023968A1 (zh)
EP (1) EP4067349A4 (zh)
JP (1) JP2023503672A (zh)
KR (1) KR20220108086A (zh)
CN (1) CN114929685B (zh)
AU (1) AU2020390305A1 (zh)
BR (1) BR112022010204A2 (zh)
CA (1) CA3162126A1 (zh)
MX (1) MX2022006489A (zh)
TW (1) TW202128660A (zh)
WO (1) WO2021104413A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022247942A1 (zh) 2021-05-28 2022-12-01 江苏恒瑞医药股份有限公司 一种稠合吡啶环衍生物的可药用盐、晶型及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110297A1 (en) * 2013-01-09 2014-07-17 Gilead Sciences, Inc. (hetero) arylacetamide derivatives as antiretroviral agents
WO2016033243A1 (en) * 2014-08-29 2016-03-03 Gilead Sciences, Inc. Antiretroviral agents
CN105705500A (zh) * 2013-03-01 2016-06-22 吉利德科学公司 用于治疗hiv的酰胺化合物
WO2018203235A1 (en) * 2017-05-02 2018-11-08 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
CN109890808A (zh) * 2016-08-19 2019-06-14 吉利德科学公司 用于预防性或治疗性治疗hiv病毒感染的治疗性化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1441734T1 (sl) * 2001-10-26 2007-08-31 Angeletti P Ist Richerche Bio Dihidropirimidin karboksamidni inhibitorji HIV-integraze
US7642277B2 (en) * 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US7429604B2 (en) * 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
JP6205354B2 (ja) 2011-07-06 2017-09-27 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖの処置のための化合物
AR112413A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas sólidas de un inhibidor de la cápside del vih
CA3089590C (en) 2018-02-15 2022-12-06 Gilead Sciences, Inc. Pyridine derivatives and their use for treating hiv infection

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110297A1 (en) * 2013-01-09 2014-07-17 Gilead Sciences, Inc. (hetero) arylacetamide derivatives as antiretroviral agents
CN105705500A (zh) * 2013-03-01 2016-06-22 吉利德科学公司 用于治疗hiv的酰胺化合物
WO2016033243A1 (en) * 2014-08-29 2016-03-03 Gilead Sciences, Inc. Antiretroviral agents
CN109890808A (zh) * 2016-08-19 2019-06-14 吉利德科学公司 用于预防性或治疗性治疗hiv病毒感染的治疗性化合物
WO2018203235A1 (en) * 2017-05-02 2018-11-08 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication

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Publication number Publication date
AU2020390305A1 (en) 2022-07-07
EP4067349A4 (en) 2022-12-21
KR20220108086A (ko) 2022-08-02
WO2021104413A1 (zh) 2021-06-03
MX2022006489A (es) 2022-07-04
CN114929685B (zh) 2023-12-12
TW202128660A (zh) 2021-08-01
BR112022010204A2 (pt) 2022-09-06
CA3162126A1 (en) 2021-06-03
US20230023968A1 (en) 2023-01-26
EP4067349A1 (en) 2022-10-05
JP2023503672A (ja) 2023-01-31

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