CN114917318A - Traditional Chinese medicine preparation for treating aural vertigo and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating aural vertigo and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
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- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The application provides a traditional Chinese medicine preparation for treating aural vertigo and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine preparation for treating aural vertigo comprises the following raw materials in parts by weight: 10-20 parts of radix bupleuri, 1-10 parts of rhizoma cyperi, 10-20 parts of ligusticum wallichii, 15-25 parts of rhizoma alismatis, 5-25 parts of bighead atractylodes rhizome, 10-20 parts of calamus, 10-15 parts of fructus liquidambaris, 5-15 parts of uncaria, 20-40 parts of mother of pearl and 5-15 parts of ginger. The medicinal materials have comprehensive effects of stopping dizziness and stopping reversion, and can be used for treating various vertigo.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation for treating aural vertigo and a preparation method thereof.
Background
Deafness, tinnitus and vertigo are three common clinical symptoms of otology, and the incidence rate is high; and the traditional Chinese medicine composition is frequently accompanied and mutually influenced, and brings difficulties in life, study and work and psychopsychological trauma to patients. Vertigo is an illusion of movement or position caused by a disturbance in the spatial orientation of the body, and a patient feels a rotational movement of the head or the surrounding environment, or shows an unstable feeling or a disturbance in balance. Vertigo is one of the common clinical symptoms, and 0.5 to 1.0 percent of people suffer from vertigo. The incidence rates in men and women over 70 years old were 47% and 61%, respectively. Aural vertigo refers to sudden vertigo caused by the disorder of the ear orifices and dysfunction of the ears, accompanied by tinnitus, deafness and ear distress, which is usually caused by the invasion of pathogenic factors into the inner ear, or weakness of zang-fu organs, malnutrition of the inner ear, or phlegm, turbid water and dampness overflowing the inner ear. Dizziness, nausea, vomiting, tinnitus, and difficulty in opening and closing the eyes. Patients with this disorder usually have tinnitus as a precursor, followed by deafness and vertigo. Vertigo is usually rotational, even more severe with nausea, vomiting, pale complexion, cold sweating or blood pressure reduction, but clear consciousness and other symptoms are manifested suddenly, with attack time of minutes to hours and intermittent period of days to months or more.
Vertigo is considered as some basic syndromes in western medicine, and clinical departments related to vertigo comprise otorhinolaryngology, ophthalmology, orthopaedics and internal medicine. The main treatment methods include using promethazine and tranquilization rhizoma Zingiberis recens, using atropine and anisodamine to prevent emesis, and using mannitol to promote urination. The disease is treated, symptoms can be relieved, but the disease has repeated attacks, the attack time interval is not fixed, but the attack is carried out once and no more. The disease has high incidence rate, the existing Chinese and western medicines have no special curative effect, the treatment difficulty is high, the cost is high, and the problems are all urgently to be solved.
Disclosure of Invention
The application aims to provide the traditional Chinese medicine preparation for treating the aural vertigo, and the traditional Chinese medicine preparation for treating the aural vertigo has the advantages of good treatment effect and low cost.
Another objective of the present application is to provide a method for preparing a Chinese medicinal preparation for treating aural vertigo, so as to obtain the Chinese medicinal preparation.
The technical problem to be solved by the application is solved by adopting the following technical scheme.
On one hand, the embodiment of the application provides a traditional Chinese medicine preparation for treating aural vertigo, which comprises the following raw materials in parts by weight: 10-20 parts of radix bupleuri, 1-10 parts of rhizoma cyperi, 10-20 parts of ligusticum wallichii, 15-25 parts of rhizoma alismatis, 5-25 parts of bighead atractylodes rhizome, 10-20 parts of calamus, 10-15 parts of fructus liquidambaris, 5-15 parts of uncaria, 20-40 parts of nacre and 5-15 parts of ginger.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine preparation for treating aural vertigo, which comprises the following steps:
mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, adding ethanol, reflux extracting for 2-4 times, mixing extractive solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract 1;
adding water to the rest raw materials, decocting for 2-4 times, filtering, mixing filtrates, and concentrating the filtrate to obtain fluid extract 2;
mixing the fluid extract 1 and the fluid extract 2, drying, and crushing into fine powder to obtain the final product of the Chinese medicinal preparation.
Bupleurum root: bitter in taste and slightly cold in nature. It enters liver and gallbladder meridians. Harmonize exterior and interior, soothe liver and raise yang. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, prolapse of son and sense organs, and proctoptosis.
Rhizoma cyperi: pungent, slightly bitter, slightly sweet and neutral in nature. It enters liver, spleen and triple energizer meridians. Move qi and relieve depression, regulate menstruation and alleviate pain. Can be used for treating stagnation of qi due to stagnation of liver-qi, chest pain, hypochondrium pain, abdominal distention and pain, dyspepsia, chest and abdominal distention and fullness, hernia due to cold, abdominal pain, breast pain, menoxenia, amenorrhea, and dysmenorrhea.
Ligusticum wallichii: pungent flavor and warm nature. It enters liver, gallbladder and pericardium meridians. Promote blood circulation and move qi, dispel wind and alleviate pain. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Rhizoma alismatis: sweet in flavor and cold in nature. It enters kidney and bladder meridians. Induce diuresis, clear damp-heat. Can be used for treating dysuria, edema, abdominal distention, diarrhea, oliguria, phlegm retention, vertigo, and pain due to stranguria and heat; hyperlipidemia.
White atractylodes rhizome: bitter and sweet in taste and warm in nature. It enters spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. Tu Bai Zhu strengthens spleen, harmonizes stomach and prevents abortion. Can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and threatened abortion.
Calamus: pungent and bitter with warm nature. It enters heart and stomach meridians. Resolve dampness, stimulate appetite, induce resuscitation, eliminate phlegm, refresh mind and promote intelligence. Can be used for treating epigastric fullness, inappetence, dysentery, coma, epilepsy, amnesia, and deafness.
The road is through: bitter taste and mild nature. It enters liver and kidney meridians. Dispel wind, activate collaterals, induce diuresis and dredge meridians. Can be used for treating arthralgia, numbness, spasm, edema, distention and amenorrhea.
Uncaria: sweet taste and cool nature. It enters liver and pericardium meridians. Clear heat and pacify liver, stop wind and calm convulsion. Can be used for treating headache, vertigo, common cold, convulsion, epilepsy, and eclampsia during pregnancy; hypertension is caused.
Mother-of-pearl: salty taste and cold nature. It enters liver and heart meridians. Pacify liver and subdue yang, calm fright and improve vision. Can be used for treating headache, vertigo, dysphoria, insomnia, liver heat, conjunctival congestion, liver deficiency, and blurred vision.
Ginger: pungent in flavor and slightly warm in nature. It enters lung, spleen and stomach meridians. Relieve exterior syndrome, dispel cold, warm middle energizer, arrest vomiting, resolve phlegm and stop cough. Can be used for treating common cold due to wind-cold, emesis due to stomach cold, and cough due to cold phlegm.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
the inventor believes that pathogenesis is caused by various reasons, one of the reasons is that the vertigo is caused by falling, head trauma, blood overflow, qi stagnation and blood stasis, or qi deficiency and blood stasis after a long period of disease, or phlegm and blood stasis, which cause brain collateral obstruction, auricular orifice obstruction, qi and blood can not nourish and clear orifices, so the vertigo is performed; the two livers are the viscera of the aeolian wood, send out fire internally, use yang for body yin, prefer to reach and rise mainly, mainly dredge and discharge, rely on kidney essence to nourish, if the emotion is not so good, it is apt to cause the stagnation of liver qi, the qi stagnation transforms into fire, the dark consumption of liver yin, yin does not restrain yang, wind-yang disturbs the clear orifices, then vertigo, if body yin deficiency, water fails to keep the body, then liver yang is hyperactivity, disturbs the clear orifices, also can cause vertigo; the third is improper diet or overstrain/anxiety, which damages the spleen and stomach, causing dysfunction of the spleen in transportation, inability to transport and transform water-dampness, dampness accumulation and phlegm generation, phlegm turbidity blocking the middle energizer, clear yang failing to rise, turbid yin failing to descend, and dizziness due to obstruction of the clear orifices. Based on the reasons, the inventor uses the rhizoma cyperi, the ligusticum wallichii, the ginger, the calamus and the beautiful sweetgum fruit to cooperate to play the roles of ventilating and activating channels, inducing resuscitation and dredging collaterals, facilitating qi and blood circulation, and nourishing and clearing orifices; the bupleurum, the uncaria and the nacre are matched for practical use, so as to sooth the liver, regulate qi, calm the liver, stop dizziness, lower the adverse flow of qi and stop vomiting; rhizoma Acori Calami, Atractylodis rhizoma and Alismatis rhizoma are used in combination for promoting the transportation and transformation of water and dampness, and regulating spleen and stomach to invigorate spleen and eliminate phlegm. The medicinal materials have comprehensive effects of stopping dizziness and stopping reversion, and can be used for treating various vertigo.
According to the application, the radix bupleuri, the rhizoma cyperi, the ligusticum wallichii and the uncaria rhynchophylla are extracted by using ethanol, other medicinal materials are extracted by using water, effective components in each medicinal material can be fully obtained, and the clear paste obtained by extraction is combined and dried, so that the obtained traditional Chinese medicine preparation is obvious in effect, and the raw materials are fully utilized. In addition, the raw materials in the application are all easily available, and the composition does not contain endangered or scarce medicinal materials, is easy to produce and has easily available resources.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
The embodiment provides a traditional Chinese medicine preparation for treating aural vertigo, which comprises the following raw materials in parts by weight: 10-20 parts of radix bupleuri, 1-10 parts of rhizoma cyperi, 10-20 parts of ligusticum wallichii, 15-25 parts of rhizoma alismatis, 5-25 parts of bighead atractylodes rhizome, 10-20 parts of calamus, 10-15 parts of fructus liquidambaris, 5-15 parts of uncaria, 20-40 parts of nacre and 5-15 parts of ginger. The inventor believes that pathogenesis is caused by various reasons, one of the reasons is that the vertigo is caused by falling, head trauma, blood overflow, qi stagnation and blood stasis, or qi deficiency and blood stasis after a long period of disease, or phlegm and blood stasis, which cause brain collateral obstruction, auricular orifice obstruction, qi and blood can not nourish and clear orifices, so the vertigo is performed; the two livers are the viscera of the aeolian wood, send out fire internally, use yang for body yin, prefer to reach and rise mainly, mainly dredge and discharge, rely on kidney essence to nourish, if the emotion is not so good, it is apt to cause the stagnation of liver qi, the qi stagnation transforms into fire, the dark consumption of liver yin, yin does not restrain yang, wind-yang disturbs the clear orifices, then vertigo, if body yin deficiency, water fails to keep the body, then liver yang is hyperactivity, disturbs the clear orifices, also can cause vertigo; the third is improper diet or overstrain/anxiety, which injures spleen and stomach, causing dysfunction of spleen in transportation, inability to transport and transform water-dampness, accumulation of dampness and generation of phlegm, phlegm turbidity blocking the middle energizer, clear yang failing to rise, turbid yin failing to descend, and dizziness due to obstruction of clear orifices. Based on the reasons, the inventor uses the rhizoma cyperi, the ligusticum wallichii, the ginger, the calamus and the beautiful sweetgum fruit to cooperate to play the roles of ventilating and activating channels, inducing resuscitation and dredging collaterals, facilitating qi and blood circulation, and nourishing and clearing orifices; the bupleurum, the uncaria and the nacre are matched for practical use, so as to sooth liver and regulate qi, calm liver and stop dizziness, and calm adverse-rising energy and stop vomiting; rhizoma Acori Calami, Atractylodis rhizoma and Alismatis rhizoma are used in combination for promoting digestion, regulating spleen and stomach, invigorating spleen, eliminating dampness, and eliminating phlegm with rhizoma Zingiberis recens and rhizoma Acori Calami. The medicinal materials have comprehensive effects of stopping dizziness and stopping reverse flow, and can be used for treating various vertigo diseases.
In some embodiments of the present application, the traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 15-20 parts of radix bupleuri, 5-10 parts of rhizoma cyperi, 12-17 parts of ligusticum wallichii, 20-25 parts of rhizoma alismatis, 10-20 parts of bighead atractylodes rhizome, 12-16 parts of calamus, 12-14 parts of fructus liquidambaris, 8-12 parts of uncaria, 25-35 parts of mother of pearl and 8-12 parts of ginger.
In some embodiments of the present application, the traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 18 parts of radix bupleuri, 8 parts of rhizoma cyperi, 15 parts of ligusticum wallichii, 23 parts of rhizoma alismatis, 15 parts of bighead atractylodes rhizome, 14 parts of calamus, 13 parts of fructus liquidambaris, 10 parts of uncaria, 30 parts of mother-of-pearl and 10 parts of ginger.
The embodiment also provides a preparation method of the traditional Chinese medicine preparation for treating aural vertigo, which is characterized by comprising the following steps of:
mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, adding ethanol, reflux extracting for 2-4 times, mixing extractive solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract 1;
adding water to the rest raw materials, decocting for 2-4 times, filtering, mixing filtrates, and concentrating the filtrate to obtain fluid extract 2;
mixing the fluid extract 1 and the fluid extract 2, drying, and crushing into fine powder to obtain the final product of the Chinese medicinal preparation. According to the application, the radix bupleuri, the rhizoma cyperi, the ligusticum wallichii and the uncaria rhynchophylla are extracted by ethanol, other medicinal materials are extracted by water, effective components in each medicinal material can be fully obtained, and then the clear paste obtained by extraction is combined and dried, so that the obtained traditional Chinese medicine preparation is obvious in effect, and raw materials are fully utilized. In addition, the raw materials in the application are all easily available, and the composition does not contain endangered or scarce medicinal materials, is easy to produce and has easily available resources.
In some embodiments of the present application, the weight ratio of the mixture of the bupleurum root, the cyperus tuber, the chuanxiong rhizome and the uncaria stem with ethanol is 1: (10-15). Under the proportion, the extraction efficiency is optimal.
In some embodiments of the present application, the ethanol is present at a concentration of 65% by volume. The ethanol with the volume concentration has the best extraction effect on effective components in bupleurum, nutgrass galingale rhizome, Szechuan lovage rhizome and uncaria.
In some embodiments of the present application, the reflux extraction is performed for 1 to 2 hours per extraction.
In some embodiments of the present application, the above fluid extract 1 and fluid extract 2 have a relative density of 1.1-1.15 at 60 deg.C.
In some embodiments of the present application, the weight ratio of the remaining raw materials to water is 1: (10-13), wherein the decoction time is 1-2h each time. In the proportion, the decoction is carried out, so that effective components can be conveniently and fully extracted.
In some embodiments of the present application, the above-mentioned dried fine powder is further added with an auxiliary material, and the auxiliary material comprises dextrin and/or a flavoring agent. The flavoring agent comprises sweetener, aromatic, mucilage or effervescent.
In some embodiments of the present application, the dosage form of the above-mentioned traditional Chinese medicine composition is pills, granules, capsules, tablets or powders.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A preparation method of a traditional Chinese medicine preparation for treating aural vertigo comprises the following steps:
raw materials: 100g of radix bupleuri, 10g of rhizoma cyperi, 100g of ligusticum wallichii, 150g of rhizoma alismatis, 50g of bighead atractylodes rhizome, 100g of calamus, 100g of fructus liquidambaris, 50g of uncaria, 200g of nacre and 50g of ginger.
Mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, and mixing at a ratio of 1: 10, adding 65 percent ethanol by volume concentration, extracting for 2 times under reflux, extracting for 1 hour each time, combining the extracting solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain clear paste 1 with the relative density of 1.1-1.15 at 60 ℃;
and (3) mixing the rest raw materials according to the proportion of 1: 10, adding water according to the weight ratio, decocting for 2 times, each time for 1 hour, filtering, combining the filtrates, and concentrating the filtrate into clear paste 2 with the relative density of 1.1-1.15 at 60 ℃;
mixing the fluid extract 1 and fluid extract 2, drying, and pulverizing into fine powder;
adding adjuvants into the fine powder to obtain the final product.
Example 2
A preparation method of a traditional Chinese medicine preparation for treating aural vertigo comprises the following steps:
raw materials: 150g of radix bupleuri, 50g of rhizoma cyperi, 120g of ligusticum wallichii, 200g of rhizoma alismatis, 100g of bighead atractylodes rhizome, 120g of calamus, 120g of fructus liquidambaris, 80g of uncaria, 250g of nacre and 80g of ginger.
Mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, and mixing at a ratio of 1: 12, adding 65 percent ethanol by volume concentration, extracting for 3 times by reflux, extracting for 1.5h each time, combining the extracting solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain clear paste 1 with the relative density of 1.1-1.15 at 60 ℃;
and (3) mixing the rest raw materials according to the proportion of 1: 11, adding water according to the weight ratio, decocting for 3 times, each time for 1.5 hours, filtering, combining the filtrates, and concentrating the filtrate to obtain a clear paste 2 with the relative density of 1.1-1.15 at 60 ℃;
mixing the fluid extract 1 and fluid extract 2, drying, and pulverizing into fine powder;
adding adjuvants into the fine powder to obtain the final product.
Example 3
A preparation method of a traditional Chinese medicine preparation for treating aural vertigo comprises the following steps:
raw materials: 180g of bupleurum, 80g of nutgrass galingale rhizome, 150g of szechuan lovage rhizome, 230g of oriental waterplantain rhizome, 150g of largehead atractylodes rhizome, 140g of calamus, 130g of beautiful sweetgum fruit, 100g of uncaria, 300g of nacre and 100g of ginger.
Mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, and mixing at a ratio of 1: 13, adding 65 percent ethanol by volume concentration, extracting for 3 times under reflux, extracting for 1.5h each time, combining the extracting solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain clear paste 1 with the relative density of 1.1-1.15 at 60 ℃;
and (3) mixing the rest raw materials according to the proportion of 1: 11, adding water according to the weight ratio, decocting for 3 times, each time for 1.5 hours, filtering, combining the filtrates, and concentrating the filtrate to obtain a clear paste 2 with the relative density of 1.1-1.15 at 60 ℃;
mixing the fluid extract 1 and fluid extract 2, drying, and pulverizing into fine powder;
adding adjuvants into the fine powder to obtain the final product.
Example 4
A preparation method of a traditional Chinese medicine preparation for treating aural vertigo comprises the following steps:
raw materials: 200g of radix bupleuri, 100g of rhizoma cyperi, 170g of ligusticum wallichii, 250g of rhizoma alismatis, 200g of bighead atractylodes rhizome, 160g of calamus, 140g of beautiful sweetgum fruit, 120g of uncaria, 350g of nacre and 120g of ginger.
Mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, and mixing at a ratio of 1: 14, adding 65 percent ethanol by volume concentration into the mixture, performing reflux extraction for 4 times, extracting for 2 hours each time, combining the extracting solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain a clear paste 1 with the relative density of 1.1-1.15 at 60 ℃;
and (3) mixing the rest raw materials according to the proportion of 1: 12, decocting for 4 times with water for 1.5h each time, filtering, mixing filtrates, and concentrating the filtrate to obtain fluid extract 2 with relative density of 1.1-1.15 at 60 deg.C;
mixing the fluid extract 1 and fluid extract 2, drying, and pulverizing into fine powder;
adding adjuvants into the fine powder to obtain the final product.
Example 5
A preparation method of a traditional Chinese medicine preparation for treating aural vertigo comprises the following steps:
raw materials: 200g of radix bupleuri, 100g of rhizoma cyperi, 250g of ligusticum wallichii, 250g of rhizoma alismatis, 250g of bighead atractylodes rhizome, 200g of calamus, 150g of fructus liquidambaris, 150g of uncaria, 400g of nacre and 150g of ginger.
Mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, and mixing at a ratio of 1: 15, adding 65 percent ethanol by volume concentration into the mixture, performing reflux extraction for 4 times, extracting for 2 hours each time, mixing the extracting solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain a clear paste 1 with the relative density of 1.1-1.15 at 60 ℃;
and (3) mixing the rest raw materials according to the proportion of 1: 13, adding water according to the weight ratio, decocting for 4 times, decocting for 2 hours each time, filtering, mixing filtrates, and concentrating the filtrate to obtain fluid extract 2 with a relative density of 1.1-1.15 at 60 ℃;
mixing the fluid extract 1 and fluid extract 2, drying, and pulverizing into fine powder;
adding adjuvants into the fine powder to obtain the final product.
Comparative example 1
This comparative example is essentially the same as example 3, except that: the Concha Margaritifera is replaced by Os Draconis.
A preparation method of a traditional Chinese medicine preparation for treating aural vertigo comprises the following steps:
raw materials: 180g of radix bupleuri, 80g of rhizoma cyperi, 150g of ligusticum wallichii, 230g of rhizoma alismatis, 150g of rhizoma atractylodis macrocephalae, 140g of calamus, 130g of fructus liquidambaris, 100g of uncaria, 300g of dragon bone and 100g of ginger.
Mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, and mixing at a ratio of 1: 13, adding 65 percent ethanol by volume concentration into the mixture, performing reflux extraction for 3 times, extracting for 1.5 hours each time, combining the extracting solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain clear paste 1 with the relative density of 1.1-1.15 at 60 ℃;
mixing the rest raw materials according to the weight ratio of 1: 11, adding water according to the weight ratio, decocting for 3 times, each time for 1.5h, filtering, combining the filtrates, and concentrating the filtrate to obtain fluid extract 2 with a relative density of 1.1-1.15 at 60 ℃;
mixing the fluid extract 1 and fluid extract 2, drying, and pulverizing into fine powder;
adding adjuvants into the fine powder to obtain the final product.
Examples of the experiments
87 patients with aural vertigo are selected as research objects and divided into a control group (28 cases) and an experimental group (59 cases) according to different treatment schemes, wherein the control group comprises 15 men and 13 women; the age is 22-49 years old. The experimental groups were 27 men and 32 women, aged 24-53 years. The experimental groups were randomly divided into 2 groups, 29 in experimental 1 group, and 30 in experimental 2 group.
Inclusion criteria were: the diagnosis standard of otolaryngological diseases of traditional Chinese medicine is met; the vertigo assessment scale is less than 80 points; the age is 22-59 years old; patients and family members voluntarily participated in the study.
Exclusion criteria: long course of disease and recurrent attacks; it can be used for treating hypertension, anemia, and other intracranial and otic organic diseases.
The treatment method comprises the following steps: the control group was treated with vertigo treating tablets (Guilin Sanjin pharmaceutical industry GmbH, national Standard Z45020605) which are administered after meal 3 times a day, 3 tablets per time. Experiments 1-2 groups of the Chinese medicinal preparation prepared in example 2 and comparative example 1, respectively, in the form of granules were treated. The medicine is orally taken after meals, 8g per time and 3 times per day.
And (3) clinical evaluation:
the reference Vestibular Symptom Index (VSI) of the control group and the experimental group comprises dizziness, nausea, headache, balance and visual effect, each item is 0-10 points, and the higher the score is, the heavier the symptom is prompted. The results are shown in Table 1.
TABLE 1
In combination with table 1, it can be seen that the treatment effect is most prominent in the experiment 1 group before and after the treatment, while the treatment effects are lower in both the experiment 2 group and the control group than in the experiment 1 group. Compared with the experiment 1 group and the experiment 2 group, the experiment 2 group uses the traditional Chinese medicine preparation prepared in the comparative example 1, and the difference from the experiment 3 is only that the nacre is replaced by the keel, but in terms of curative effect, the curative effect is obviously faster than that of the experiment 3, because the medicine proportion of the traditional Chinese medicine preparation is reasonably considered by the inventor of the application, although the efficacy of the nacre and the keel is similar, the efficacy of the medicine of the experiment 3 is obviously outstanding due to the cooperation of the medicines. For both the experiment 1 group and the control group, the treatment effect of the experiment 1 group was superior to that of the control group in the post-treatment scores of items of dizziness, nausea, headache, balance and visual effect. This shows that the Chinese medicinal preparation prepared by the application has outstanding treatment effect on aural vertigo.
In conclusion, the inventor of the present application thinks that the pathogenesis is caused by various reasons, one of which is that the pathogenesis is caused by falling from a sudden onset, head trauma, blood overflow and extravasation, qi stagnation and blood stasis, or qi deficiency and blood stasis after a long period of disease, or phlegm and blood stasis, so brain collateral obstruction, earhole obstruction, qi and blood can not nourish and clear orifices, so vertigo is caused; the two livers are the organs of the wind-wood, internally catch fire, use yang for body yin, like to be in a state of being in water being in a state of being in the body, being in a state of being; the third is improper diet or overstrain/anxiety, which injures spleen and stomach, causing dysfunction of spleen in transportation, inability to transport and transform water-dampness, accumulation of dampness and generation of phlegm, phlegm turbidity blocking the middle energizer, clear yang failing to rise, turbid yin failing to descend, and dizziness due to obstruction of clear orifices. Based on the reasons, the inventor uses the rhizoma cyperi, the ligusticum wallichii, the ginger, the calamus and the beautiful sweetgum fruit to cooperate to play the roles of ventilating and activating channels, inducing resuscitation and dredging collaterals, facilitating qi and blood circulation, and nourishing and clearing orifices; the bupleurum, the uncaria and the nacre are matched for practical use, so as to sooth the liver, regulate qi, calm the liver, stop dizziness, lower the adverse flow of qi and stop vomiting; rhizoma Acori Calami, Atractylodis rhizoma and Alismatis rhizoma are used in combination for promoting digestion, regulating spleen and stomach, invigorating spleen, eliminating dampness, and eliminating phlegm with rhizoma Zingiberis recens and rhizoma Acori Calami. The medicinal materials have comprehensive effects of stopping dizziness and stopping reverse flow, and can be used for treating various vertigo diseases.
According to the application, the radix bupleuri, the rhizoma cyperi, the ligusticum wallichii and the uncaria rhynchophylla are extracted by using ethanol, other medicinal materials are extracted by using water, effective components in each medicinal material can be fully obtained, and the clear paste obtained by extraction is combined and dried, so that the obtained traditional Chinese medicine preparation is obvious in effect, and the raw materials are fully utilized. In addition, the raw materials in the application are all easily available, and the composition does not contain endangered or scarce medicinal materials, is easy to produce and has easily available resources.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.
Claims (10)
1. The traditional Chinese medicine preparation for treating aural vertigo is characterized by comprising the following raw materials in parts by weight: 10-20 parts of radix bupleuri, 1-10 parts of rhizoma cyperi, 10-20 parts of ligusticum wallichii, 15-25 parts of rhizoma alismatis, 5-25 parts of bighead atractylodes rhizome, 10-20 parts of calamus, 10-15 parts of fructus liquidambaris, 5-15 parts of uncaria, 20-40 parts of mother of pearl and 5-15 parts of ginger.
2. The traditional Chinese medicine preparation for treating aural vertigo according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15-20 parts of radix bupleuri, 5-10 parts of rhizoma cyperi, 12-17 parts of ligusticum wallichii, 20-25 parts of rhizoma alismatis, 10-20 parts of bighead atractylodes rhizome, 12-16 parts of calamus, 12-14 parts of fructus liquidambaris, 8-12 parts of uncaria, 25-35 parts of mother of pearl and 8-12 parts of ginger.
3. The traditional Chinese medicine preparation for treating aural vertigo according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 18 parts of radix bupleuri, 8 parts of rhizoma cyperi, 15 parts of ligusticum wallichii, 23 parts of rhizoma alismatis, 15 parts of bighead atractylodes rhizome, 14 parts of calamus, 13 parts of beautiful sweetgum fruit, 10 parts of uncaria, 30 parts of nacre and 10 parts of ginger.
4. The preparation method of the traditional Chinese medicine preparation for treating aural vertigo as claimed in any one of claims 1 to 3, comprising the following steps:
mixing bupleuri radix, rhizoma Cyperi, rhizoma Ligustici Chuanxiong and ramulus Uncariae cum uncis, adding ethanol, reflux extracting for 2-4 times, mixing extractive solutions, filtering, recovering ethanol under reduced pressure, and concentrating to obtain fluid extract 1;
adding water to the rest raw materials, decocting for 2-4 times, filtering, mixing filtrates, and concentrating the filtrate to obtain fluid extract 2;
mixing the fluid extract 1 and the fluid extract 2, drying, and crushing into fine powder to obtain the final product of the Chinese medicinal preparation.
5. The preparation method of the traditional Chinese medicine preparation for treating aural vertigo according to claim 4, wherein the weight ratio of the mixture of the bupleurum root, the rhizoma cyperi, the ligusticum wallichii and the uncaria rhynchophylla to the ethanol is 1: (10-15).
6. The method for preparing a Chinese medicinal preparation for treating aural vertigo according to claim 4, wherein the volume concentration of ethanol is 65%.
7. The method for preparing a Chinese medicinal preparation for treating aural vertigo according to claim 4, wherein the time for each extraction of reflux extraction is 1-2 h.
8. The preparation method of the traditional Chinese medicine preparation for treating aural vertigo according to claim 4, wherein the relative density of the clear paste 1 and the clear paste 2 at 60 ℃ is 1.1-1.15.
9. The preparation method of the traditional Chinese medicine preparation for treating aural vertigo according to claim 4, wherein the weight ratio of the rest raw materials to water is 1: (10-13), wherein the decoction time is 1-2h each time.
10. The preparation method of the traditional Chinese medicine preparation for treating aural vertigo according to claim 4, wherein auxiliary materials are further added after the traditional Chinese medicine preparation is dried into fine powder, and the auxiliary materials comprise dextrin and/or flavoring agents.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1626159A (en) * | 2003-12-12 | 2005-06-15 | 董亮 | Method for preparing pills of quenching dizziness |
| CN102552860A (en) * | 2012-02-22 | 2012-07-11 | 陕西中医学院制药厂 | Chinese medicinal preparation for treating vertigo and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626159A (en) * | 2003-12-12 | 2005-06-15 | 董亮 | Method for preparing pills of quenching dizziness |
| CN102552860A (en) * | 2012-02-22 | 2012-07-11 | 陕西中医学院制药厂 | Chinese medicinal preparation for treating vertigo and preparation method thereof |
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| 潘勇;岳媛萍;陶怀燕;: "通窍活血汤合通气散治疗气滞血瘀型久聋86例" * |
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