CN106039189B - It relieves summer heat oral solution and preparation method thereof - Google Patents
It relieves summer heat oral solution and preparation method thereof Download PDFInfo
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- CN106039189B CN106039189B CN201610490565.1A CN201610490565A CN106039189B CN 106039189 B CN106039189 B CN 106039189B CN 201610490565 A CN201610490565 A CN 201610490565A CN 106039189 B CN106039189 B CN 106039189B
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Abstract
It relieves summer heat oral solution and preparation method thereof the present invention provides one kind, belongs to health food preparation technical field.The oral preparation that the oral solution of relieving summer heat is formulated by the following Chinese medicine material formed by weight: folium panacis japonici cum caule 190g-290g, elscholtiza 240g-360g, lotus leaf 150g-220g, wrinkled giant hyssop 190g-290g, radix aucklandiae 120g-180g, Semen Lablab Album 150g-220g, Cortex Magnoliae Officinalis 120g-180g, Amomum cardamomum 120g-180g, Radix Astragali 150g-220g, Rhizoma Atractylodis Macrocephalae 120g-180g, eupatorium 150g-220g, root of Dahurain angelica 150g-220g.The present invention just combines careful entirely, and compatibility is fastidious, sunstroke prevention of gathering altogether relieves summer heat, dampness elimination and in, invigorating qi for consolidating superficies the effect of, and effective component is extracted sufficiently, thus extremely hot to summer, and heat, heatstroke are hurt in prevention, and hurt the treatment of heat, heatstroke, all have excellent effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine health-care oral solutions, especially a kind of to have effects that the health food that sunstroke prevention is relieved summer heat is oral
Liquid and preparation method thereof belongs to health food preparation technical field.
Background technique
With warming for global climate, now, temperature is higher and higher, and weather is more and more warmmer, each department 35 in each year
DEG C or more the number of days of temperature increased significantly.Thereupon, because high temperature hot summer weather cause to hurt the disease incidences such as heat, heatstroke also obvious
Increase.
Hurt heat and is also known as " affection by summer-heat ".Refer to that summer wound in summer-heat evil, hidrosis body heat occurs, restlessness and thirst, rough, four limbs are tired, small
Just red puckery equal card shape.Motherland's medicine is divided into yang summer-heat syndrome and yin summer-heat syndrome heat is hurt, " person that is dynamic and obtaining is yang summer-heat syndrome ", patient's labor mostly under burning sun
Make, or activity for a long time, or long working is caused under high temperature, improper ventilation, the higher environment of humidity.Cardinal symptom has
Fever, vexed, sweating, dizziness, headache, uncomfortable in chest, nauseous, tongue fur is yellowish-white and dry, superficial and rapid pulse etc..And " yin summer-heat syndrome " is because excessively keeping away
Heat covet it is cool cause, i.e., it is so-called " quiet and the person that obtains is yin summer-heat syndrome ".It mostly dries and enjoys the cool because of hot weather, or drink is cold immoderate, in middle gas
Void is invaded and is caused so that the heresy of hot summer weather and chill is taken advantage of a weak point in opponent's defence.Main symptom have fever with chilliness, lossless, body weight pain, it is tired,
Tongue nature is light, moss thin yellow, small and wiry pulse etc..Especially old man, children, pregnant and lying-in women, it is weak and with chronic ill person be easy induce this disease.
Heatstroke refers to that physical exertion, movement, operation etc. are engaged in exposure in the high temperature environment or in hot environment for a long time
Cause one group of clinical syndrome caused by body body heat regulation dysfunction, with high fever, profuse sweating, it is thirsty, dizzy, headache, nausea,
It vomits or the central nervous system symptoms such as burst faints, twitches, is even urinary and fecal inconvenience is characterized, often the state of an illness is critical.It is reported that
Body temperature reach 40 DEG C be prognosis mala indication, body temperature be more than 41 DEG C serious heatstroke case fatality rate be 41.7%, if more than 42 DEG C,
Case fatality rate is 81.3%.
In short, in summer, or activity of being exposed to the sun under burning sun, or operation at high temperature, or leave burning sun and have a shower immediately, or
Air conditioning chamber's rapid cooling is immediately entered under high temperature or the air conditioning chamber Jiu Ju immediately enters the condition of high temperature again, so that sweaing all over or the summer
There is giddy, alliteration, headache, discomfort uncomfortable in chest, nausea, gastric disorder causing nausea, out of strength etc. and hurt heat symptom in day cold and cool cold drink of overfeeding etc., less serious case；
Severe one occurs dizzy, and alliteration, head severe pain is uncomfortable in chest, and vomiting, shortness of breath, limbs are aching and tired, fatigue and weakness or thirst and drinking or the more skins of sweat
Cold or fever and chills are lossless, and oliguria is short red, notably the heatstroke symptom of unexpected stupor, twitch etc., not only seriously damage human health, heavy
Person's threat to life.
Strictly, do not have really to prevent and release the Chinese materia medica preparation of heatstroke and health food on Vehicles Collected from Market.But demand
Crowd is usually by ageratum oral liquid (water, ball, capsule) as sunstroke prevention, the drug of relieving summer-heat.In fact, we carefully look at wrinkled giant hyssop
The related data of positive invigorating oral liquid will clearly be found: first, ageratum oral liquid derives from " peaceful the Bureau of People's Welfare Pharmacies
Just " the huoxiang zhengqi powder of a book, changing powder is oral solution (water, ball, capsule).Second, from the aspect of prescription and drug and effect,
Original side is total by Rhizoma Atractylodis Macrocephalae, dried orange peel, Cortex Magnoliae Officinalis, the root of Dahurain angelica, Poria cocos, the shell of areca nut, Rhizoma Pinelliae Fermentata, Radix Glycyrrhizae, wrinkled giant hyssop, purple perilla, campanulaceae, ginger, jujube
The drug of 13 herbal medicines composition, energy driving away summer heat only has wrinkled giant hyssop simply, after powder is changed to oral solution, also changes, goes to original prescription
Ginger is fallen, jujube, campanulaceae, Rhizoma Atractylodis Macrocephalae separately joined rhizoma atractylodis.Mainly by damp-resolving medicinal, qi-regulating drug, diaphoretic medicine composition etc., effect
It is inducing diaphoresis dampness elimination, qi-regulating is in.Third cures mainly " affection of exogenous wind-cold, internal injury humidity hysteresis disease, disease from the aspect of curing mainly symptom from original prescription
See fever with aversion to cold, have a headache, chest diaphragm hides bored, epigastric pain, nausea and vomiting, borborygmus diarrhea, white and greasy fur and clouds and mists in the mountains malignant malaria from ", this
It just clearly illustrates, the party is the exogenous diseases for treatment " affection of exogenous wind-cold, internal injury humidity hysteresis " and sets originally.In a system of former prescription
Column text solution is right, and does not refer to " heat " word, also the prescription of non-sunstroke prevention relieving summer-heat, and especially effect is little in terms of sunstroke prevention, the reason is that
Main ingredient composition in prescription is not relieving summer-heat drug, so relieving summer-heat effect is not very good.But in practical applications, many of heatstroke
Symptom is such as: dizzy, headache, uncomfortable in chest, nausea, the diseases such as vomiting are similar to the primary symptom of the party, and when use is also effective, so, demand
Crowd is just used as driving away summer heat, but said preparation and the preparation of non-optimal prevention and treatment heatstroke, in ancient prescription and clinical practice
In, the prescription for preventing and treating heatstroke is Xiangru San, and in tcm clinical practical application, perfume (or spice) is all selected in sunstroke prevention and treatment heatstroke
Ru dissipates plus-minus.
It is found through retrieval, that has announced at present has effects that the Chinese medicine patent application of reducing temperature of heatstroke prevention mainly has:
1, the Chinese patent application of publication number CN 104258267A discloses a kind of sunstroke prevention Chinese medicine on January 7th, 2015
Preparation, the Chinese materia medica preparation are made of the Chinese herb of following parts by weight: 20-30 grams of elscholtiza, 10-20 grams of Fructus Forsythiae, wrinkled giant hyssop 10-20
Gram, 10-20 grams of perilla leaf, 10-20 grams of lotus leaf, 10-20 grams of pawpaw, 10-20 grams of flower of hyacinth dolichos, 10-20 grams of luffa, tsaoko 8-12
Gram, 8-15 grams of the shell of areca nut, 8-12 grams of pueraria lobata, 8-12 grams of Radix Curcumae, 8-12 grams of Exocarpium Citri Rubrum, 8-12 grams of peppermint, 8-12 grams of five leaves lotus, purple cool
8-12 grams, 8-12 grams of cow-bezoar.All medicines are well-matched, and play nourishing yin and clearing heat altogether, throat soothing of promoting the production of body fluid, eliminating dampness and heat, and nourishing generate fluid is relieved summer heat only
Yearningly, the effect of reducing temperature of heatstroke prevention, human body can be replenished in time under high temperature environment, the moisture lost due to excessive sweating and lemon
The organic principles such as acid, glucose, multivitamin.
Motherland's medicine is dialectical to treat during preventing and curing diseases, the specification and theoretical foundation that principle-method-recipe-medicines have its stringent,
It is not at will to select several drugs, matched combined is exactly a prescription, catches main disease when dialectical, and primary symptom, protrusion cures mainly when treatment
Main method, when prescription, must there is main side's main ingredient, and monarch is clearly demarcated in prescription, and the main side of main ingredient is clear, is only a stricti jurise in this way
On Chinese medicinal formulae, could also generate strong therapeutic effect.Said preparation is from flavour of a drug, and totally 17 taste is exactly to people's impression
Innumerable and disordered, monarch is unknown, the main Fang Buqing of main ingredient.From pharmacological action and performance perspective, 5 groups can be divided into:
First group: tsaoko, wrinkled giant hyssop, purple cool, pawpaw, the shell of areca nut, luffa, common effect are row water clearing damps, middle benefit gas and
Stomach；
Second group: purple perilla, pueraria lobata, peppermint, effect is relieving exterior syndrome and dispelling cold, dispelling wind and heat from the body；
Third group: Fructus Forsythiae, cow-bezoar, five leaves lotus, effect is clearing heat and detoxicating；
4th group: elscholtiza, flower of hyacinth dolichos, lotus leaf, effect are inducing diaphoresis of relieving summer heat, and dampness elimination is in；
5th group: Radix Curcumae, Exocarpium Citri Rubrum, effect are regulating qi-flowing for strengthening spleen, relieve stagnation analgesic；
After concluding in this way, just it is not difficult to find out that, the effect of said preparation, can sum up are as follows: clearing damp and in, inducing diaphoresis heat-clearing, promoting the circulation of qi solution
Heat, with emphasis on clearing damp, followed by inducing diaphoresis heat-clearing is finally only promoting the circulation of qi relieving summer-heat.Said preparation conception is " sunstroke prevention ", but is divided from above
Analysis is seen, " anti-" this theme is not shown.Heatstroke is exactly treated, effect is also fainter.Since flavour of a drug are excessive, in a jumble, medicine
Object interaction, mutually restricts, runs counter to desire.
2, the Chinese patent application of publication number CN 104757676A discloses a kind of Chinese medicine health-care on July 8th, 2015
Beverage and preparation method thereof comprising the component of following parts by weight: 20~40 parts of lophatherum gracile, 10~20 parts of Radix Astragali, chrysanthemum 10
~30 parts, 10~20 parts of reed root, 5~15 parts of Radix Ophiopogonis, 5~15 parts of fructus lycii and 3000~8000 parts of water.The invention with lophatherum gracile,
Radix Astragali, chrysanthemum, reed root, Radix Ophiopogonis and fructus lycii be raw material, herbal cuisine is homologous, and many medicines share, can reach clearing heat and detoxicating, cooling of relieving summer heat,
Sharp fire defaecation, the effect of promoting the production of body fluid to quench thirst.Meanwhile without the chemical addition agents such as antibacterial agent, preservative, natural environmental-protective, without any poison
Side effect.However there is no " clearing heat and detoxicating, cooling of relieving summer heat " pharmaceutical compositions in the formula, so disappearing also without clearing heat and detoxicating
The effect of heat cools down, does not belong to medicine for relieving summer-heat or relieving summer-heat health care product scope.
In conclusion ageratum oral liquid is not the drug of sunstroke prevention and treatment heatstroke, only play symptomatic treatment；It is open
Patent " heatstroke prevention chinese medicine preparation (CN104258267A) " by clearing damp and in, relieving superficies by cooling has been placed on emphasis position, and driving away summer heat
It being placed on secondly, being originally intended to " prevent ", but popular medicine for heat stroke is few, ingredient is extremely low, so sunstroke prevention effect is extremely weak.Also, the magistral medicines
Taste is numerous, and prescription is mixed and disorderly, does not protrude main side's main ingredient, monarch fuzzy, it is difficult to reach ideal therapeutic effect.It is disclosed
The Six-element Chinese medicine effect of CN104757676A patent, the effect of describing and formula is not inconsistent, both without clear simply in the formula
The drug of thermal detoxification, also without relieving summer-heat driving away summer heat drug simply, therefore, said preparation is not belonging to driving away summer heat class drug.Vehicles Collected from Market as a result,
Upper no sunstroke prevention is relieved summer heat oral preparation sale.
For this purpose, the crowd under developing a kind of high-temperature situation for hot summer weather, to prevent to hurt the generation of heat, heatstroke；Or to
Hurt heat, heatstroke, the patient with sympotoms such as giddy, alliteration, headache, uncomfortable in chest, nauseous, gastric disorder causing nausea occurs and treated；And due to summer
It is cold excessively to covet cool drink, so that there is fever with aversion to cold in affection of exogenous wind-cold, internal injury summer-heat and damp, headache and adiapneustia, nausea and vomiting, abdominal pain diarrhea
" yin summer-heat syndrome ", the oral preparation of Chinese traditional medicinal that the illness such as similar air conditioner disease are prevented and treated are very necessary.
Summary of the invention
Present invention seek to address that Vehicles Collected from Market does not have effective sunstroke prevention to relieve summer heat Chinese medicine and health food, and existing it is related to heat-clearing
Removing toxic substances, the preparation of effect of cooling down of relieving summer heat, that there are flavour of a drug is excessive, mixed and disorderly, effect is little, it is difficult to reach asking for ideal treatment
Topic, thus provide it is a kind of to because high temperature hot summer weather cause to hurt the disease prevention and cure such as heat, heatstroke effect good, and have effects that replenish qi to invigorate the spleen
Sunstroke prevention relieve summer heat oral solution and preparation method thereof.
Realize foregoing invention purpose, The technical solution adopted by the invention is as follows:
One kind is relieved summer heat oral solution, it is characterised in that: it is formulated by the following Chinese medicine material formed by weight
Oral preparation:
Folium panacis japonici cum caule 190g-290g, elscholtiza 240g-360g, lotus leaf 150g-220g, wrinkled giant hyssop 190g-290g, radix aucklandiae 120g-
180g, Semen Lablab Album 150g-220g, Cortex Magnoliae Officinalis 120g-180g, Amomum cardamomum 120g-180g, Radix Astragali 150g-220g, Rhizoma Atractylodis Macrocephalae 120g-
180g, eupatorium 150g-220g, root of Dahurain angelica 150g-220g.
Further, the dosage of the Chinese medicine material are as follows:
It is folium panacis japonici cum caule 160-250g, elscholtiza 280-350g, lotus leaf 160-200g, wrinkled giant hyssop 280-350g, radix aucklandiae 130-170g, white
Hyacinth bean 160-200g, Cortex Magnoliae Officinalis 130-170g, Amomum cardamomum 130-170g, Radix Astragali 160-200g, Rhizoma Atractylodis Macrocephalae 130-170g, eupatorium 160-
200g, root of Dahurain angelica 160-200g.
Further, the dosage of the Chinese medicine material are as follows:
It is folium panacis japonici cum caule 240g, elscholtiza 300g, lotus leaf 180g, wrinkled giant hyssop 240g, radix aucklandiae 150g, Semen Lablab Album 180g, Cortex Magnoliae Officinalis 150g, white
Cardamom 150g, Radix Astragali 180g, Rhizoma Atractylodis Macrocephalae 150g, eupatorium 180g, root of Dahurain angelica 180g.
The preparation method of the oral solution of relieving summer heat comprises the technical steps that:
A, elscholtiza, wrinkled giant hyssop, eupatorium, the root of Dahurain angelica, Rhizoma Atractylodis Macrocephalae, Amomum cardamomum, radix aucklandiae, Cortex Magnoliae Officinalis eight traditional chinese medicines raw material are uniformly mixed, are added
Enter the water for 5 times of the eight traditional chinese medicines raw material gross weight, impregnates 3~5 hours, then boiled in extractor, use steam distillation
Method is extracted volatile oil 60~80 minutes, and oil extract to be evaporated is completed, and remaining medical fluid and the dregs of a decoction are separated, and collects obtain respectively
Filtrate 1 and the dregs of a decoction 1, wherein after Tween 80 is added by the 5% of volatile oil total weight in volatile oil, keep in；
B, after mixing folium panacis japonici cum caule, Radix Astragali, lotus leaf, four taste Chinese medicine material of Semen Lablab Album, four taste Chinese medicine thus is added for the first time
The water that 3 times of raw material gross weight impregnates 3~5 hours, after merging with the dregs of a decoction 1 collected in step A, is added for the second time to close
And 2 times of total weight of water decocts 50~60 minutes after the dregs of a decoction 1, filtering, collection obtains filtrate 2 and the dregs of a decoction 2；
C, the dregs of a decoction 2 that will be collected in step B are incorporated as the water of 2 3~5 times of volumes of weight of the dregs of a decoction, decoct 30~40 points
Clock, filtering, obtains filtrate 3；
D, filtrate 1, filtrate 2, filtrate 3 are merged, the ethyl alcohol that concentration of volume percent is 90% is added, until filtrate
In concentration of alcohol reach 60% until, then alcohol precipitation 24 hours precipitation solution；
E, after the precipitation solution of step D being recycled ethyl alcohol, extracting solution is collected, extracting solution is concentrated into it initially at 80 DEG C
The 15% of volume, collection obtain concentrate；
F, the resulting concentrate of step E and the step A volatile oil extracted are mixed, obtain total mixed liquor, then plus
Enter distilled water, make medical fluid overall control at 2520 milliliters, adds preservative to get oral liquid formulations product.
The preservative is the PhCOONa solution that content is 0.2%, and additional amount by weight is medical fluid total amount
2%。
The oral liquid formulations product is dispensed by 20 milliliters every, and mounted box obtains finished product after sterilizing.
Initial volume described in step E refers to: " by elscholtiza, wrinkled giant hyssop, eupatorium, the root of Dahurain angelica, Rhizoma Atractylodis Macrocephalae, white described in step A
Cardamom, radix aucklandiae, Cortex Magnoliae Officinalis eight traditional chinese medicines raw material are uniformly mixed, and are incorporated as the water of 5 times of the eight traditional chinese medicines raw material gross weight, impregnate 3~5
The volume number of the mixed liquor obtained after hour ".
Step A, in B, C, the additional amount of water is by a ml/g addition.
The instructions of taking and the course for the treatment of of oral solution of the present invention are as follows: sunstroke prevention, it is adult 2-3 times, every time 1 daily；Treatment hurt heat or
Heatstroke, it is adult 3 times a day, 1 every time；Seven years old to 12 all the time child dose halve, seven years old or less children are 5-10 milliliters each.
The material combination and major function of oral solution of the present invention are described as follows below:
Heatstroke is human body under high temperature and the long duration of action of heat radiation, and obstacle, water, electrolyte occurs in body body heat regulation
The general name of metabolic disorder and nervous system dysfunction symptom is a kind of acute disease of thermal balance disorder and generation.It can divide
At three kinds: one is the thermoplegia being easy to appear in sultry room, patient may feel that headache, dizziness, thirsty, then body
Warm raising rapidly, pulse quickening, facial flushes, or even stupor.Second is sunstroke, if people under burning sun activity or
Residence time is too long, and directly under the exposure of burning sun, strong daylight penetration head skin and skull cause brain cell impaired, into
And the hyperemia of brain tissue, oedema are caused, since the position to come to harm is mainly head, so, most start head temperature occur
Increase, then severe headache, nausea and vomiting, dysphoria, then may occur in which stupor and twitch, but body temperature not necessarily increases.The
Three kinds are heat cramps, and in the high temperature environment, body can largely perspire people, are lost a large amount of salt, are kept the sodium content in blood too low,
Cause leg even four limbs and whole-body muscle spasm.No matter which kind of situation, root is " heat ", belongs to the exogenous disease six external factors which cause diseases, is seasonal
Multiple disease there is specific season and pathogenic factor, i.e. summer hot summer weather, and heat must press from both sides wet.So prophylactic treatment should then grab
Firmly eliminate summer heat and remove dampness this emphasis, and prevention is particularly important, anti-better than controlling, and the injury that prevention is avoidable or mitigation is to human body has
Effect ground protection human health.After the onset of, traditional Chinese medicine treats with unique advantage and speciality it.For the cause of disease and morbidity
Mechanism takes heat-clearing of relieving summer heat, and dampness elimination is in, the rule to replenish qi to invigorate the spleen, produces effects very significant.Relieve summer heat heat-clearing, dampness elimination and in be needle
Is truncated by pathogenic pathways, achievees the purpose that treatment to eliminate the cause of disease for the counter-measure that the cause of disease is adopted pair；It replenishes qi to invigorate the spleen, is enhancing
Body own healing mechanism, expulsion is saturating in addition to disease and evil, so that body is not fallen ill or the state of an illness mitigates and rehabilitation.
In formula:
Folium panacis japonici cum caule, slight bitter and sweet, cold in nature, clearing lung-heat promote the production of body fluid, quench the thirst.Smell is pure and fresh, the dual work with driving away summer heat and QI invigorating
With supplementary Amplifications of the Compendium of Materia Medica is recorded: " bowl spares band table, can give birth to greatly stomach saliva, and the fire of deficiency type, the sharp four limbs head drop in driving away summer heat gas." closed with elscholtiza
The power relieved summer heat with more increasing.It is the outstanding feature of we with folium panacis japonici cum caule's sunstroke prevention relieving summer-heat.
Elscholtiza, pungent, tepor, return lung, spleen, stomach meridian.Lung channel inducing sweat and dispelling exogenous evils can be entered and cold dispelling；Its fragrant odour enters taste again
Can dampness elimination and in and driving away summer heat, be the key medicine that sunstroke prevention is relieved summer heat, be the main ingredient of this formula.It there are also a feature be summer is coveted it is cool drink it is cold
Excessive " yin summer-heat syndrome " disease has unique preventive and therapeutic action.
Lotus leaf, mildly bitter flavor is puckery, mild-natured, enters lung, the spleen channel, clearing summer-heat and damp, sending up the lucid yang, Compendium of Material Medica is stated are as follows: " refrigerant
Relieving summer-heat is slaked thirst and help produce saliva ".
Wrinkled giant hyssop, acrid flavour, slightly warm in nature；Enter lung, spleen, stomach meridian；Driving away summer heat inducing diaphoresis, removing dampness to restore normal functioning of the stomach, preventing or arresting vomiting.It is chiefly used in cold-damp affecting spleen institute
The stomach duct and abdomen ruffian of cause is bored, the diseases such as vomiting.
Radix aucklandiae, pungent, bitter, temperature enters spleen, stomach, large intestine, gallbladder, tri-jiao channel, have promoting qi circulation and relieving pain, warming middle-JIAO for easing the stomach, spasmolysis decompression and
Antibacterial action.As Compendium of Material Medica is said: " radix aucklandiae is the medicine of three burnt gas point, can go up and down all gas." clinic is chiefly used in all pains of the stagnation of the circulation of vital energy, spleen
Stomach Qi deficiency, the card such as vomiting caused by transporting inability, diarrhea, tenesmus.
Semen Lablab Album, sweet in flavor, slightly warm in nature, invigorating the spleen for eliminating dampness, and in relieve summer heat.For weakness of the spleen and the stomach, loss of appetite, diarrhea,
Summer-heat and damp is vomited and diarrhoea, abdominal distension uncomfortable in chest.
Cortex Magnoliae Officinalis, it is bitter, pungent, it is warm-natured；Returns spleen, stomach, lung, large intestine channel；For in humidity hysteresis wound, abdominal swelling and diarrhea, stagnation of QI due to dyspepsia, abdomen
Swollen constipation, sputum cough.
Amomum cardamomum, acrid flavour is warm-natured, return lung, spleen, stomach meridian, has the effect of dampness elimination promoting the circulation of qi, warming middle energizer to arrest vomiting, is usually used in spleen deficiency
The fullness and oppression of chest and abdomen of retention of damp leading to blockage of QI, it is especially most suitable with the vomiting of stagnation of cold-damp mechanism of qi.
Radix Astragali, sweet in flavor, slightly warm in nature；Return lung, spleen, liver and kidney channel；There are invigorating qi for consolidating superficies, air making-up and spleen enlivening, inducing diuresis for removing edema, detoxification, life
The effect of flesh, suitable for spontaneous perspiration, night sweat, blood-arthralgia, edema, un-festering of ulcer or bursts and does not hold back etc. diseases long.It can enhance and adjust body and exempt from
The disease resistance of body can be improved in epidemic disease function.
Rhizoma Atractylodis Macrocephalae, bitter is sweet, warm-natured, returns spleen, stomach meridian；Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis.For spleen eating less, abdominal distension
Diarrhea, phlegm retention anti-dazzle nervous, oedema, the diseases such as spontaneous perspiration.
Eupatorium, acrid flavour put down, enter spleen, stomach meridian；There are antipyretic clear heat, dispelling damp-cold from the stomach and improving appetite and digestion, preventing or arresting vomiting.For experiencing summer-heat and damp, tremble with fear
Heat headache, it is wet it is turbid in accumulate, gastral cavity ruffian is not hungry, nausea and vomiting are sweet etc. in mouth.
The root of Dahurain angelica, it is acrid in flavour and warm in nature, enter lung, spleen, stomach meridian；Fragrant odour has relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping effect.Headache is cured mainly,
Pain in the supra-orbital bone, dentalgia, nasosinusitis, cold-dampness stomachache etc. mainly take its inducing diaphoresis to relieve pain, the function eliminated dampness with aromatics here.
Further, the mutual synergistic effect in formula between each Chinese medicine material is: elscholtiza relieving exterior syndrome and dispelling cold in side, driving away summer heat
It is wet, it is the key medicine that sunstroke prevention is relieved summer heat, and we are for its " monarch " medicine in the main ingredient and side for preventing and treating main sick primary symptom.
Folium panacis japonici cum caule, lotus leaf, wrinkled giant hyssop, the clear heat of eupatorium are relieved summer heat, clearing damp stomach function regulating, and the function that enhancing elscholtiza sunstroke prevention is relieved summer heat is Fang Zhongchen
Medicine；Folium panacis japonici cum caule relieves summer heat, the double effects of QI invigorating and the good merchantable brand of sunstroke prevention, is the outstanding characteristic and advantage of we.Folium panacis japonici cum caule,
Lotus leaf shares, and enhances the power for clear heat of relieving summer heat.It focuses in " clear "；Wrinkled giant hyssop, eupatorium focus on " removing dampness by means of aromatics " with clearing damp dampness elimination weighting.
And wrinkled giant hyssop mutually must be used with eupatorium, the power of mutual assistance virtue, enhance dampness elimination effect.
The root of Dahurain angelica, relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, then this primary treatment and disease-releasing headache, eliminate dampness with aromatics, are also ministerial drug.
Radix Astragali, Rhizoma Atractylodis Macrocephalae, Semen Lablab Album invigorating qi for consolidating superficies, invigorating spleen, prominent " Gu " word, the benefits of taking its " defence ", reach memory
The purpose of healthy tendency, the benefits of " sunstroke prevention ", " Gu just " can be played.It can prevent summer-heat evil injury and treat oneself healthy tendency through injuring, i.e.,
" prevention of diseae, disease then control ", adjutant in the side of being；Folium panacis japonici cum caule has relieving summer-heat QI invigorating double effects, is also able to cooperate Radix Astragali herein and consolidates table
Power, enhance sunstroke prevention effect.
Radix aucklandiae, Amomum cardamomum, Cortex Magnoliae Officinalis play promoting the circulation of qi dampness elimination, warming middle-JIAO for easing the stomach effect altogether.Summer-heat evil is caused a disease, wound in table, it is seriously ill
Taste, therefore uncomfortable in chest, evil of vomitting is its key reaction, so the main means of prevention and treatment are then expelling superficial pathogens and clearing away summer-heats, removing dampness to restore normal functioning of the stomach, stomach function regulating then must
It need regulating functional activities of qi.Using this three taste, reach regulating functional activities of qi, removing dampness to restore normal functioning of the stomach is uncomfortable in chest to release, the disease of evil of vomitting, for making in side
Medicine.
Elscholtiza, Cortex Magnoliae Officinalis, hyacinth bean are the Xiangru San in " formulary of peaceful benevolent dispensary ", are that sunstroke prevention relieves summer heat, is also to control heat proved recipe, and main side shows
Existing primary symptom, main ingredient, main side formulation principle.
In short, the Six-elements such as folium panacis japonici cum caule, elscholtiza, lotus leaf, wrinkled giant hyssop, eupatorium, hyacinth bean are directly against heat in 12 taste Chinese medicine of this formula
Evil prevention and treatment, sunstroke prevention control having a distinct theme for heat, give prominence to the key points, and have caught " heat ", " anti-", and " disappearing " this emphasis is also simultaneous
The pathology rule wet, retardance this summer-heat evil of mechanism of qi is caused a disease must be pressed from both sides by having cared for heat, using radix aucklandiae, white peas or beans bandit, Cortex Magnoliae Officinalis, dispel the wet of taste
And regulating functional activities of qi, the effect of making main ingredient, are more significant.It is slandered to prevent summer-heat evil, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Semen Lablab Album Gu Wei is used in side
Table is protected, building up healthful vital energy more cleverly selects folium panacis japonici cum caule to relieve summer heat QI invigorating, so that heat is disappeared just and help, bring out the best in each other in addition, and effect is significant.
Mutual synergistic effect in being formulated simultaneously between each Chinese medicine material is: the root of Dahurain angelica helps scattered table outside elscholtiza, wrinkled giant hyssop evil, fragrant
The turbid function of sweetening treatment, and be yangming headache key medicine, to solve the disadvantage of headache.Since heat must press from both sides wet, injuring spleen-stomach, so after hurting heat, it is first
The symptom first occurred is exactly dizziness, and alliteration is had a headache, and uncomfortable in chest, the diseases such as evil of vomitting, we are stopped with wrinkled giant hyssop, Amomum cardamomum dampness elimination promoting the circulation of qi, middle benefit gas
Vomit, then plus eupatorium expelling summer-heat and damp, and mutually must be used with wrinkled giant hyssop, more increase the function of relieving summer-heat, stop evil of vomitting must, summer-heat and damp must be changed, summer heat from
It removes.Meanwhile summer-heat and damp injures taste then functional activity of QI being not smooth, therefore uncomfortable in chest, evil of vomitting, we use radix aucklandiae, Cortex Magnoliae Officinalis with regulating functional activities of qi, promoting the circulation of qi removes
It is full, it is drying damp and strengthening spleen.In addition, Rhizoma Atractylodis Macrocephalae, Radix Astragali take its air making-up and spleen enlivening, invigorating qi for consolidating superficies, Semen Lablab Album invigorating the spleen for eliminating dampness and in, mend without stagnant,
In addition the function of the QI invigorating of folium panacis japonici cum caule, makes the strong fortune of temper, middle controlled atmosphere and, Biao Wei get is solid, to reach healthy tendency memory, the effect that heresy can not be done
Fruit makes prevention of diseae, and disease is then controlled.Elscholtiza, Cortex Magnoliae Officinalis, " Xiangru San " that Semen Lablab Album is " formulary of peaceful benevolent dispensary " are sunstroke prevention essence sides, even more
Heat proved recipe, main side are controlled, is also the main side of this formula.
To sum up, the present invention just combines careful entirely, compatibility is fastidious, motivated, there is sunstroke prevention to relieve summer heat, dampness elimination and in,
The effect of invigorating qi for consolidating superficies, thus it is extremely hot to summer, and heat, heatstroke are hurt in prevention, and hurt the treatment of heat, heatstroke, all have splendid effect
Fruit.
Further to investigate the clinical efficacy and safety that oral solution sunstroke prevention of the invention of relieving summer heat is relieved summer heat, exist the 7-9 month in 2015
Institute of traditional Chinese medicine, the city XX, First People's Hospital, the city XX are extracted two groups of clinic cases altogether at random and are tested, and prevention group 93, wherein male
Property 52, women 41；It is the oldest 68 years old, 13 years old minimum, have and meets heat experience.Treatment group 139, wherein male 76,
It is female's surname 63, the oldest 69 years old, 11 years old minimum；It is diagnosed as hurting heat 57, heatstroke 82.
Diagnostic criteria: meet national " disease of tcm Standardization of diagnosis and curative effect ", (" traditional Chinese medicine Journal of Management " 1997 06
Phase).It works under all cases belong under hot summer weather environment or burning sun is exposed to the sun or high temperature, or immediately enters air conditioning chamber after being exposed to the sun, or
It is exposed to the sun in the case where cool environment immediately enters burning sun, then occurs hurting heat, all diseases of heatstroke；Or do not occur hurting heat heatstroke symptom, but have
Above-mentioned chance heat experience, to prevent from hurting heat, heatstroke disease occurs.
One, application method: this formula is pressed into aforementioned preparation process, hospital preparation is made.
1, prevent: all demand crowds for having above-mentioned chance heat experience make it take this preparation, 2-3 time daily, 1 time 1, be total to
It takes two days.
2, it treats: it is all because of above-mentioned reason, occur hurting heat, heatstroke symptom, is diagnosed as the patient for hurting heat, heatstroke, takes it
This preparation, it is 2-3 times daily, 1 time 1, take altogether two days.(such as patient's constitution is strong, and the inclined severe one of symptom, can aggravate dose).
Further consultation two days later, to observe the state of an illness, symptom mitigates but is not cured person entirely, then takes two days again to recovery from illness.
Two, efficacy assessment standard:
1, prevent
It is effective: to have and meet heat experience, after taking this preparation, do not occur hurting heat, heatstroke symptom or sign；
It is effective: to have and meet heat experience, after taking this preparation, still have and hurt heat, heatstroke symptom, but symptom relatively passed through and in the short period
Symptom disappears.
It is invalid: to have and meet heat experience, after taking this preparation, hurt heat, heatstroke symptom occurs and gradually aggravates.
2, it treats
It is effective: to be diagnosed as and hurt heat or heatstroke, after taking this preparation, symptom and sign disappear within a short period of time.
It is effective: to be diagnosed as and hurt heat or heatstroke, after taking this preparation, symptom and sign are gradually alleviated, after aggravating taking dose
It disappears；
It is invalid: to be diagnosed as and hurt heat or heatstroke, after taking this preparation, symptom and sign are without alleviation, or have exacerbation trend, need another
Take other treatment method person.
Three, efficacy result:
1, prevent:
Effective 67, effective 25, invalid 1, total effective rate 98.9%.
2, it treats:
Effective 86, effective 51, invalid 2, total effective rate 98.6%.
Advantageous effects and clinical effectiveness of the invention show:
1, using oral liquid formulations made from prescriptions of traditional Chinese medicine of the present invention, there is sunstroke prevention to relieve summer heat, dampness elimination and in, invigorating qi for consolidating superficies it
Effect, extremely hot to summer, heat, heatstroke are hurt in prevention, and hurt the prevention and treatment of heat, heatstroke, and curative effect and health-care effect are definite, and effect is good.
2, since elscholtiza, wrinkled giant hyssop, eupatorium, the root of Dahurain angelica, Rhizoma Atractylodis Macrocephalae, White Chloe, radix aucklandiae, Cortex Magnoliae Officinalis eight traditional chinese medicines raw material contain volatilization
Oil, and volatile oil component therein for treatment and prevention hurt heat, heatstroke has very important effect, therefore first by this eight
Taste Chinese medicine material carries out mixing extraction, and the volatile oil extracted is added in Tween 80 after dissolution is temporary, then with other raw materials
It mixes and extracts remaining effective component, to can ensure that sufficiently mentioning for volatile oil component and aqueous soluble active constituent in raw material
It takes.
3, there is preferable dissolution to most drugs effective component due to ethyl alcohol, thus uses alcohol in step D
Heavy method, and under relevant parameter control condition, thus can ensure that effective ingredient is completely dissolved in water, and impurity is then deposited
Below, then by separation supernatant, the low effective component of impurity content can be obtained.
4, the full side's combination of the present invention is careful, and compatibility is fastidious, sunstroke prevention of gathering altogether relieves summer heat, dampness elimination and in, invigorating qi for consolidating superficies the effect of, because
And it is extremely hot to summer, heat, heatstroke are hurt in prevention, and hurt the treatment of heat, heatstroke, all have excellent effect.
Specific embodiment
Embodiment 1
One kind is relieved summer heat oral solution, the oral preparation that it is formulated by the following Chinese medicine material formed by weight: people
Join 190 g of leaf, elscholtiza 250g, 150 g of lotus leaf, 200 g of wrinkled giant hyssop, radix aucklandiae 150g, 150 g of Semen Lablab Album, 120 g of Cortex Magnoliae Officinalis, Amomum cardamomum
150 g, 150 g of Radix Astragali, 120 g of Rhizoma Atractylodis Macrocephalae, 150 g of eupatorium, 160 g of the root of Dahurain angelica.
Embodiment 2
One kind is relieved summer heat oral solution, the oral preparation that it is formulated by the following Chinese medicine material formed by weight: people
Join 290 g of leaf, 320 g of elscholtiza, 220 g of lotus leaf, 250 g of wrinkled giant hyssop, 180 g of radix aucklandiae, 200 g of Semen Lablab Album, 180 g of Cortex Magnoliae Officinalis, white peas or beans
Cool 120 g, 220 g of Radix Astragali, 150 g of Rhizoma Atractylodis Macrocephalae, 220 g of eupatorium, root of Dahurain angelica 200g.
Embodiment 3
One kind is relieved summer heat oral solution, the oral preparation that it is formulated by the following Chinese medicine material formed by weight: people
Join leaf 250g, elscholtiza 240g, lotus leaf 180g, wrinkled giant hyssop 190g, radix aucklandiae 120g, Semen Lablab Album 180g, Cortex Magnoliae Officinalis 150g, Amomum cardamomum 180g,
Radix Astragali 180g, Rhizoma Atractylodis Macrocephalae 180g, eupatorium 200g, root of Dahurain angelica 150g.
Embodiment 4
One kind is relieved summer heat oral solution, the oral preparation that it is formulated by the following Chinese medicine material formed by weight: people
Join leaf 270g, elscholtiza 360g, lotus leaf 200g, wrinkled giant hyssop 290g, radix aucklandiae 160g, Semen Lablab Album 220g, Cortex Magnoliae Officinalis 140g, Amomum cardamomum 160g,
Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 130g, eupatorium 180g, root of Dahurain angelica 220g.
Embodiment 5
The preparation method of oral solution of relieving summer heat described in embodiment 1-4 comprises the technical steps that:
A, elscholtiza, wrinkled giant hyssop, eupatorium, the root of Dahurain angelica, Rhizoma Atractylodis Macrocephalae, Amomum cardamomum, radix aucklandiae, Cortex Magnoliae Officinalis eight traditional chinese medicines raw material are uniformly mixed, are added
Enter the water for 5 times of the eight traditional chinese medicines raw material gross weight, impregnates 3~5 hours, then boiled in extractor, use steam distillation
Method is extracted volatile oil 60~80 minutes, and oil extract to be evaporated is completed, and remaining medical fluid and the dregs of a decoction are separated, and collects obtain respectively
Filtrate 1 and the dregs of a decoction 1, wherein after Tween 80 is added by the 5% of volatile oil total weight in volatile oil, keep in；
B, after mixing folium panacis japonici cum caule, Radix Astragali, lotus leaf, four taste Chinese medicine material of Semen Lablab Album, four taste Chinese medicine thus is added for the first time
The water that 3 times of raw material gross weight impregnates 3~5 hours, after merging with the dregs of a decoction 1 collected in step A, is added for the second time to close
And 2 times of total weight of water decocts 50~60 minutes after the dregs of a decoction 1, filtering, collection obtains filtrate 2 and the dregs of a decoction 2；
C, the dregs of a decoction 2 that will be collected in step B are incorporated as the water of 2 3~5 times of volumes of weight of the dregs of a decoction, decoct 30~40 points
Clock, filtering, obtains filtrate 3；
D, filtrate 1, filtrate 2, filtrate 3 are merged, the ethyl alcohol that concentration of volume percent is 90% is added, until filtrate
In concentration of alcohol reach 60% until, then alcohol precipitation 24 hours precipitation solution；
E, after the precipitation solution of step D being recycled ethyl alcohol, extracting solution is collected, extracting solution is concentrated into it initially at 80 DEG C
The 15% of volume, collection obtain concentrate；
F, the resulting concentrate of step E and the step A volatile oil extracted are mixed, obtain total mixed liquor, then plus
Enter distilled water, make medical fluid overall control at 2520 milliliters, then is incorporated as the PhCOONa solution (benzene of medical fluid total amount 2% by weight
The content of sodium formate is 0.2%) to get oral liquid formulations product.
The oral liquid formulations product is dispensed by 20 milliliters every, and mounted box obtains finished product after sterilizing.
Step A, in B, C, the additional amount of water is by a ml/g addition.
It is further demonstrated that below by curative effect of the specific case to oral solution of the invention of relieving summer heat
Case 1
Zheng XX, male, 33 years old, Among The Migrant Construction Workerss, consultation time: on July 19th, 2015, temperature was 35-37 within the next few days
Between DEG C, patient removes brick in construction site, giddy when medical, headache, malaise, it is uncomfortable in chest, be intended to spit, but that spits does not go out, and sweat is more,
The white thickness of tongue fur, superficial and rapid pulse.Diagnosis: heatstroke.Prescription: oral solution 6 of relieving summer heat (hospital preparation, 20 milliliters every).Administration: every time 1
Branch, three times a day.Further consultation again after advising medication two days, patient examines again within second day.It states, takes 2 certainly for the first time, medicine 30 minutes after medication,
Symptom subtracts greatly, is that nausea is substantially reduced first, and evil of vomitting symptom disappears after one hour, and dizzy, all diseases of headache mitigate therewith, the
It more improves after secondary medication.To when going to a doctor, a micro- dusk is seen, appetite is not good enough, allows and takes two days this preparations again.Next day telephone questionnaire,
It has fully recovered.
Case 2
Xu X, female, 27 years old, office worker, consultation time, on July 26th, 2015.Because being warm, air conditioning chamber time compared with
It is more, and many times after air conditioning chamber's work, and immediately enter and be exposed to the sun under daylight, it is repeated multiple times in this way, currently there is alliteration
Bitterly, dizzy, uncomfortable in chest, do not feel like eating, abdomen secret anguish, limbs are miserable, out of strength, tongue fur is white, floating and tense pulse.Diagnosis: hurt heat.Prescription: disappear
Heat oral solution 6 (hospital preparation, 20 milliliters every), 1 every time, three times a day, third day communication on telephone, patient's readme, disease is
More, it no longer needs to take medicine.
Case 3
King XX, male, 41, porter, consultation time: on August 13rd, 2015.Medical noon before that day, weather is awfully hot, from
It after thing is carried, goes home to have a shower immediately, drying again with electric fan after having a shower, it is cool to take, and opens electric fan sleep at night, feels dizzy from morning today
Dizzy, alliteration, fear of wind, nausea be intended to spit, have aches in the limbs, inability, tongue fur are white, superficial and rapid pulse.Diagnosis: heatstroke, prescription: oral solution of relieving summer heat
6 (hospital preparation, 20 milliliters every), 1 every time, three times a day.The further consultation of third day, all symptoms of readme have been eliminated very much, disease
Feelings have been clearly better, and need to consolidate, still with this preparation oral, administration with it is preceding identical.Every communication on telephone on the two, disease recovery from illness, after
Continuous working.
Claims (4)
- The oral solution 1. one kind is relieved summer heat, it is characterised in that: the mouth that it is formulated by the following Chinese medicine material formed by weight Formulation: folium panacis japonici cum caule 190g-290g, elscholtiza 240g-360g, lotus leaf 150g-220g, wrinkled giant hyssop 190g-290g, radix aucklandiae 120g- 180g, Semen Lablab Album 150g-220g, Cortex Magnoliae Officinalis 120g-180g, Amomum cardamomum 120g-180g, Radix Astragali 150g-220g, Rhizoma Atractylodis Macrocephalae 120g- 180g, eupatorium 150g-220g, root of Dahurain angelica 150g-220g；The preparation method of the oral solution of relieving summer heat comprises the technical steps that:A, elscholtiza, wrinkled giant hyssop, eupatorium, the root of Dahurain angelica, Rhizoma Atractylodis Macrocephalae, Amomum cardamomum, radix aucklandiae, Cortex Magnoliae Officinalis eight traditional chinese medicines raw material are uniformly mixed, are incorporated as The water of 5 times of the eight traditional chinese medicines raw material gross weight impregnates 3~5 hours, then boils in extractor, mentioned with steam distillation Take volatile oil 60~80 minutes, oil extract to be evaporated is completed, and remaining medical fluid and the dregs of a decoction are separated, and collects obtain filtrate respectively 1 and the dregs of a decoction 1, wherein after Tween 80 is added by the 5% of volatile oil total weight in volatile oil, keep in；B, after mixing folium panacis japonici cum caule, Radix Astragali, lotus leaf, four taste Chinese medicine material of Semen Lablab Album, four taste Chinese medicine material thus is added for the first time The water that 3 times of total weight impregnates 3~5 hours, after merging with the dregs of a decoction 1 collected in step A, is added for the second time to merge medicine 2 times of total weight of water decocts 50~60 minutes after slag 1, and filtering, collection obtains filtrate 2 and the dregs of a decoction 2；C, the dregs of a decoction 2 that will be collected in step B are incorporated as the water of 2 3~5 times of volumes of weight of the dregs of a decoction, decoct 30~40 minutes, Filtering, obtains filtrate 3；D, filtrate 1, filtrate 2, filtrate 3 are merged, the ethyl alcohol that concentration of volume percent is 90% is added, until in filtrate Until concentration of alcohol reaches 60%, then precipitation solution is obtained within alcohol precipitation 24 hours；E, after the precipitation solution of step D being recycled ethyl alcohol, extracting solution is collected, extracting solution is concentrated into its initial volume at 80 DEG C 15%, collection obtain concentrate；F, the resulting concentrate of step E and the step A volatile oil extracted are mixed, obtains total mixed liquor, be then added and steam Distilled water makes medical fluid overall control at 2520 milliliters, adds preservative to get oral liquid formulations product.
- 2. oral solution according to claim 1 of relieving summer heat, it is characterised in that: the dosage of Chinese medicine material are as follows: folium panacis japonici cum caule 240g, perfume (or spice) It is Ru 300g, lotus leaf 180g, wrinkled giant hyssop 240g, radix aucklandiae 150g, Semen Lablab Album 180g, Cortex Magnoliae Officinalis 150g, Amomum cardamomum 150g, Radix Astragali 180g, white Art 150g, eupatorium 180g, root of Dahurain angelica 180g.
- 3. oral solution according to claim 1 of relieving summer heat, it is characterised in that: preservative described in step F is that content is 0.2% PhCOONa solution.
- 4. oral solution according to claim 1 or 3 of relieving summer heat, it is characterised in that: the addition of the preservative by weight Amount is the 2% of medical fluid total amount.
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| CN103405706A (en) * | 2013-08-29 | 2013-11-27 | 张永雷 | Traditional Chinese medicine formula for treating summer damp disease and preparation method thereof |
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