CN114874288A - β-转角环状模拟肽盐的溶液相合成和结晶 - Google Patents
β-转角环状模拟肽盐的溶液相合成和结晶 Download PDFInfo
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- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562190596P | 2015-07-09 | 2015-07-09 | |
| US62/190,596 | 2015-07-09 | ||
| CN201680040450.0A CN107849089B (zh) | 2015-07-09 | 2016-07-08 | β-转角环状模拟肽盐的溶液相合成和结晶 |
| PCT/EP2016/066281 WO2017005902A1 (en) | 2015-07-09 | 2016-07-08 | Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201680040450.0A Division CN107849089B (zh) | 2015-07-09 | 2016-07-08 | β-转角环状模拟肽盐的溶液相合成和结晶 |
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| CN114874288A true CN114874288A (zh) | 2022-08-09 |
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| CN202210654769.XA Pending CN114874288A (zh) | 2015-07-09 | 2016-07-08 | β-转角环状模拟肽盐的溶液相合成和结晶 |
| CN201680040450.0A Active CN107849089B (zh) | 2015-07-09 | 2016-07-08 | β-转角环状模拟肽盐的溶液相合成和结晶 |
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| CN201680040450.0A Active CN107849089B (zh) | 2015-07-09 | 2016-07-08 | β-转角环状模拟肽盐的溶液相合成和结晶 |
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| EP (2) | EP3319978B1 (https=) |
| JP (1) | JP6801835B2 (https=) |
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| CN (2) | CN114874288A (https=) |
| AU (1) | AU2016290654C1 (https=) |
| TW (1) | TWI708779B (https=) |
| WO (1) | WO2017005902A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2016290654C1 (en) * | 2015-07-09 | 2021-11-11 | Mimetogen Pharmaceuticals, Inc. | Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts |
| US11021514B2 (en) | 2016-06-01 | 2021-06-01 | Athira Pharma, Inc. | Compounds |
| EP3802554B1 (en) * | 2018-05-31 | 2023-12-13 | Sederma | Method for solution-phase peptide synthesis and protecting strategies therefore |
| US11427612B2 (en) * | 2018-08-21 | 2022-08-30 | Wayne State University | Epimerization-free N to C solid-phase peptide synthesis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110040087A1 (en) * | 1998-03-24 | 2011-02-17 | Mimetica Pty Ltd. | Peptide turn mimetics |
| CN102046166A (zh) * | 2008-04-04 | 2011-05-04 | 米梅托根药物公司 | 治疗干眼症的方法 |
| CN102333537A (zh) * | 2009-02-27 | 2012-01-25 | 米梅托根药物公司 | 用于治疗色素性视网膜炎的模拟肽环状化合物 |
| CN104619717A (zh) * | 2012-06-22 | 2015-05-13 | 米梅奥亨制药公司 | β-转角模拟肽环状化合物的合成 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE340571T1 (de) | 2000-01-18 | 2006-10-15 | Univ Mcgill | Pharmazeutische zubereitungen enthaltend beta- turn peptidomimetische zyklische substanzen |
| KR20080058509A (ko) * | 2002-06-11 | 2008-06-25 | 일라이 릴리 앤드 캄파니 | 흥분성 아미노산의 전구약물 |
| EP2598604B1 (de) * | 2010-07-29 | 2015-11-25 | Merck Patent GmbH | Flüssigkristallines medium enthaltend thiophenderivate |
| JP5710436B2 (ja) * | 2011-09-26 | 2015-04-30 | 株式会社東芝 | パターン形成方法 |
| JP6516974B2 (ja) * | 2013-06-14 | 2019-05-22 | 豊田合成株式会社 | ゴム組成物及びゴム製品 |
| WO2014204681A1 (en) * | 2013-06-20 | 2014-12-24 | Exxonmobil Chemical Patents Inc. | Long-bridged salen catalyst |
| AU2016290654C1 (en) * | 2015-07-09 | 2021-11-11 | Mimetogen Pharmaceuticals, Inc. | Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts |
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2016
- 2016-07-08 AU AU2016290654A patent/AU2016290654C1/en active Active
- 2016-07-08 WO PCT/EP2016/066281 patent/WO2017005902A1/en not_active Ceased
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- 2016-07-08 US US15/205,909 patent/US10125165B2/en active Active
- 2016-07-08 EP EP25158656.6A patent/EP4549450A3/en active Pending
- 2016-07-08 JP JP2017567608A patent/JP6801835B2/ja active Active
- 2016-07-08 KR KR1020187003965A patent/KR102056257B1/ko active Active
- 2016-07-08 CN CN202210654769.XA patent/CN114874288A/zh active Pending
- 2016-07-08 CN CN201680040450.0A patent/CN107849089B/zh active Active
- 2016-07-11 TW TW105121814A patent/TWI708779B/zh active
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2018
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2021
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- 2023-07-18 US US18/354,076 patent/US12281179B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110040087A1 (en) * | 1998-03-24 | 2011-02-17 | Mimetica Pty Ltd. | Peptide turn mimetics |
| CN102046166A (zh) * | 2008-04-04 | 2011-05-04 | 米梅托根药物公司 | 治疗干眼症的方法 |
| CN102333537A (zh) * | 2009-02-27 | 2012-01-25 | 米梅托根药物公司 | 用于治疗色素性视网膜炎的模拟肽环状化合物 |
| CN104619717A (zh) * | 2012-06-22 | 2015-05-13 | 米梅奥亨制药公司 | β-转角模拟肽环状化合物的合成 |
Non-Patent Citations (2)
| Title |
|---|
| ANNA S. NORGREN等: "β2-Amino Acids in the Design of Conformationally Homogeneous cyclo-Peptide Scaffolds", 《THE JOURNAL OF ORGANIC CHEMISTRY》 * |
| LOUIS A. CARPINO 等: "Rapid, Continuous Solution-Phase Peptide Synthesis: Application to Peptides of Pharmaceutical Interest", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016290654A1 (en) | 2018-01-25 |
| JP6801835B2 (ja) | 2020-12-16 |
| CN107849089B (zh) | 2022-07-05 |
| KR102056257B1 (ko) | 2019-12-16 |
| EP3319978C0 (en) | 2025-02-19 |
| US20210300966A1 (en) | 2021-09-30 |
| US20230357318A1 (en) | 2023-11-09 |
| US20170008923A1 (en) | 2017-01-12 |
| EP4549450A2 (en) | 2025-05-07 |
| HK1255355A1 (en) | 2019-08-16 |
| WO2017005902A1 (en) | 2017-01-12 |
| AU2016290654C1 (en) | 2021-11-11 |
| JP2018528928A (ja) | 2018-10-04 |
| KR20180036982A (ko) | 2018-04-10 |
| AU2016290654A2 (en) | 2020-08-06 |
| US11078234B2 (en) | 2021-08-03 |
| TW201716425A (zh) | 2017-05-16 |
| EP3319978A1 (en) | 2018-05-16 |
| US10125165B2 (en) | 2018-11-13 |
| CA2991661A1 (en) | 2017-01-12 |
| AU2016290654B2 (en) | 2021-07-08 |
| US11753441B2 (en) | 2023-09-12 |
| TWI708779B (zh) | 2020-11-01 |
| EP4549450A3 (en) | 2025-07-02 |
| US20190194251A1 (en) | 2019-06-27 |
| US12281179B2 (en) | 2025-04-22 |
| CN107849089A (zh) | 2018-03-27 |
| EP3319978B1 (en) | 2025-02-19 |
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