CN114848510A - Long-acting mosquito-repelling itching-relieving spray and preparation method thereof - Google Patents
Long-acting mosquito-repelling itching-relieving spray and preparation method thereof Download PDFInfo
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- 239000007921 spray Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims abstract description 33
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 15
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 15
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 9
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- 238000003756 stirring Methods 0.000 claims description 31
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 8
- 229960004756 ethanol Drugs 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 2
- 235000013539 calcium stearate Nutrition 0.000 claims description 2
- 239000008116 calcium stearate Substances 0.000 claims description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
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- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- VQXSOUPNOZTNAI-UHFFFAOYSA-N Pyrethrin I Natural products CC(=CC1CC1C(=O)OC2CC(=O)C(=C2C)CC=C/C=C)C VQXSOUPNOZTNAI-UHFFFAOYSA-N 0.000 description 1
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- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 description 1
- VJFUPGQZSXIULQ-XIGJTORUSA-N pyrethrin II Chemical compound CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VJFUPGQZSXIULQ-XIGJTORUSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the technical field of sanitary articles, and provides a long-acting mosquito-repelling itching-relieving spray and a preparation method thereof. The components of the spray comprise 3-5 parts of eucalyptol, 1-2 parts of menthol, 1-2 parts of trehalose, 0.5-1 part of eugenol, 1-3 parts of stearate, 22-23 parts of ethanol, 62.1-70.3 parts of deionized water, 1-1.5 parts of konjac glucomannan and 0.2-0.4 part of matrine. The invention takes eucalyptol and menthol as main mosquito-repellent itching-relieving components, the added konjac glucomannan can form a high-water-content film after spraying, which not only increases the moisture feeling of skin, but also can reduce the volatilization speed of eucalyptol and menthol through the barrier effect of the film and water, and prolongs the effective time of mosquito-repellent itching-relieving.
Description
Technical Field
The invention belongs to the technical field of hygienic products, and provides a long-acting mosquito-repelling itching-relieving spray and a preparation method thereof.
Background
In summer, mosquito bites can cause inflammation such as skin itch, red swelling and the like, can also transmit diseases such as dengue fever, malaria, filariasis and the like, can reduce sleep quality and influence mood, so that the mosquito bites are troubled by people all the time in terms of body and spirit, and the mosquito prevention and the mosquito repelling are very important. The mosquito repelling method has the advantages and disadvantages that people adopt a plurality of mosquito repelling methods, such as mosquito nets, mosquito repelling screen windows, burning mosquito repellent, electric mosquito repellent liquid, mosquito repelling gel, mosquito killing lamps, mosquito repelling medicaments and the like, and the various mosquito repelling methods have the most important attention on safety and mosquito repelling effect.
The method for repelling the mosquitoes by adopting the external product containing the mosquito repelling component has the advantage of convenient use, so the application is very common. The mosquito repellent component mainly comprises synthetic mosquito repellent component (such as deet, pyrethrin, anophelifuge, etc.) and natural mosquito repellent component. The natural mosquito repellent component has higher use safety than the synthetic mosquito repellent component, but the natural mosquito repellent component is easy to volatilize and has shorter effective mosquito repellent time, so the application of the natural mosquito repellent component is limited.
Eucalyptol (1, 8-cineole) is a natural monoterpene compound, exists in plants of Eucalyptus, Salvia, Rosa, etc., has camphora-like smell, good transdermal penetration ability, and can improve pancreatitis and resist cholesterol generation. The mosquito repellent liquid has good mosquito repellent effect and obvious itching relieving and anti-inflammatory effects, and can relieve itching feeling and eliminate red swelling and other symptoms when being applied to skin bitten by mosquitoes.
Menthol (menthol) is also a natural monoterpene compound, can be extracted from stems and leaves of mint, and is widely applied to medicines, daily necessities and foods, and the menthol can not only repel mosquitoes and expel parasites, but also has the effects of cooling and relieving itching, and can relieve the itching caused by mosquito bites.
Therefore, the eucalyptol and the menthol can not only repel mosquitoes and prevent mosquitoes, but also have the effect of relieving itching, and are very suitable to be used as the effective components of the spray for repelling mosquitoes and relieving itching. However, they also have the common defects of natural mosquito-repellent components, namely easy volatilization, short effective time and difficulty in realizing long-acting mosquito-repellent itching relieving.
Disclosure of Invention
The invention provides a long-acting mosquito-repelling itching-relieving spray and a preparation method thereof.
The invention relates to a specific technical scheme as follows:
the invention provides a long-acting mosquito-repelling itching-relieving spray, which comprises the components of eucalyptol, menthol, trehalose, eugenol, stearate, ethanol, deionized water, konjac glucomannan and matrine. Preferably, the weight parts of the components are 3-5 parts of eucalyptol, 1-2 parts of menthol, 1-2 parts of trehalose, 0.5-1 part of eugenol, 1-3 parts of stearate, 22-23 parts of ethanol, 62.1-70.3 parts of deionized water, 1-1.5 parts of konjac glucomannan and 0.2-0.4 part of matrine.
Preferably, the stearate is at least one of zinc stearate, calcium stearate and magnesium stearate.
In order to prolong the effective action time of eucalyptol and menthol, the invention creatively adds konjac glucomannan in the spray. Konjac glucomannan is a natural polymer, is safe, has no toxic or side effect, has solubility, forms transparent sol after being fully dissolved, and has good film forming capability. And the konjac glucomannan has good water absorption and can lock water, after the spray is sprayed on the skin surface, the konjac glucomannan can form a thin film layer with high water content on the skin surface, so that the skin surface can be kept moist for a long time, the skin moisture feeling is increased, the volatilization speed of eucalyptol and menthol can be reduced through the barrier effect of the film layer and the water, and the effective time of mosquito repelling and itching relieving is prolonged. The addition amount of konjac glucomannan is not too small, preferably not less than 1%, because when the addition amount is too small, a continuous film layer cannot be formed, and the barrier effect is not obvious. The addition amount of konjac glucomannan is not too much, preferably not more than 1.5%, because: firstly, the influence of konjac glucomannan on the fluidity after being dissolved in water is large, and if the addition amount is too high, the spraying viscosity is large, so that the konjac glucomannan is not easy to spray or block; secondly, the addition amount of konjac glucomannan is too high, which causes the volatilization speed of eucalyptol and menthol to the air to be too slow, and cannot realize good mosquito repelling effect.
Furthermore, matrine is added into the spray. The matrine has the antibacterial and anti-inflammatory effects, can further improve the anti-inflammatory and itching-relieving effects on mosquito bites, and more importantly, the matrine can provide a certain alkaline environment, can promote the gelation of a film layer after the konjac glucomannan is formed into the film, and improves the mechanical property of the film layer, so that the damage of the film layer during activity is reduced, and the lasting mosquito-repelling and itching-relieving effects are ensured.
In addition, trehalose and eugenol are added into the spray disclosed by the invention, the trehalose can prevent skin from being damaged when the temperature is higher in summer, the skin vitality can be kept, and the eugenol has an antibacterial effect.
The invention also provides a preparation method of the long-acting mosquito-repelling itching-relieving spray, which adopts a four-time stirring method according to the dissolving capacity and volatility of each raw material, selects proper temperature, stirring speed and time for each stirring, ensures the full dissolution of soluble components and the full dispersion of insoluble components, and simultaneously reduces the volatilization of volatile components in the preparation process. The preparation steps are as follows:
(1) preheating deionized water, adding konjac glucomannan, and stirring for one time until the konjac glucomannan is transparent;
(2) adding menthol and stearate, and stirring for the second time;
(3) naturally cooling to room temperature, adding trehalose, and stirring for three times;
(4) adding eucalyptol, eugenol, ethanol, and matrine, and stirring for four times.
Preferably, in the step (1), the preheating temperature of the deionized water is 50-55 ℃.
Preferably, in the step (1), the rotation speed of one-time stirring is 500-.
Preferably, in the step (2), the rotation speed of the secondary stirring is 200-.
Preferably, in the step (3), the rotation speed of the three times of stirring is 200-.
Preferably, in the step (4), the rotation speed of the four times of stirring is 50-80 r/min, and the time is 5-10 min.
The invention provides a long-acting mosquito-repelling itching-relieving spray and a preparation method thereof, compared with the prior art, the long-acting mosquito-repelling itching-relieving spray has the outstanding characteristics and excellent effects that:
1. according to the invention, konjac glucomannan with good water absorption and film forming properties is added into the spray, a high water content film layer can be formed after spraying, the skin moisture feeling is increased, the volatilization speed of eucalyptol and menthol can be reduced through the barrier effect of the film layer and water, and the effective time of mosquito repelling and itching relieving is prolonged.
2. The matrine is added into the spray, so that the anti-inflammation and itching-relieving effects can be improved, and the gelation of the konjac glucomannan film layer can be promoted, so that the damage of the film layer during movement is reduced, and the lasting mosquito-repelling and itching-relieving effects are ensured.
3. The mosquito-repelling itching-relieving spray disclosed by the invention is simple to prepare, convenient to use and good in safety.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments, but it should not be construed that the scope of the present invention is limited to the following examples. Various substitutions and alterations can be made by those skilled in the art and by conventional means without departing from the spirit of the method of the invention described above.
Example 1
(1) Preheating deionized water to 50 ℃, adding konjac glucomannan, and stirring at 600r/min for 1h until the konjac glucomannan is transparent;
(2) adding menthol and zinc stearate, and stirring at 250r/min for 30 min;
(3) naturally cooling to room temperature, adding trehalose, and stirring at 200 r/min for 10 min;
(4) adding eucalyptol, eugenol, ethanol, and matrine, and stirring at 80 r/min for 5 min.
According to the weight portion, 5 portions of eucalyptol, 2 portions of menthol, 1 portion of trehalose, 0.5 portion of eugenol, 2 portions of zinc stearate, 22.5 portions of ethanol, 1.5 portions of konjac glucomannan, 0.4 portion of matrine and the balance of deionized water.
Example 2
(1) Preheating deionized water to 55 ℃, adding konjac glucomannan, and stirring for 1h at 500r/min until the konjac glucomannan is transparent;
(2) adding menthol and zinc stearate, and stirring at 250r/min for 20 min;
(3) naturally cooling to room temperature, adding trehalose, and stirring at 250r/min for 8 min;
(4) adding eucalyptol, eugenol, ethanol, and matrine, and stirring at 70 r/min for 8 min.
According to the weight portion, 4 portions of eucalyptol, 1.5 portions of menthol, 2 portions of trehalose, 0.7 portion of eugenol, 1 portion of zinc stearate, 22 portions of ethanol, 1.5 portions of konjac glucomannan, 0.4 portion of matrine and the balance of deionized water.
Example 3
(1) Preheating deionized water to 53 ℃, adding konjac glucomannan, and stirring at 550r/min for 1h until the konjac glucomannan is transparent;
(2) adding menthol and zinc stearate, and stirring at 220r/min for 25 min;
(3) naturally cooling to room temperature, adding trehalose, and stirring at 200 r/min for 10 min;
(4) adding eucalyptol, eugenol, ethanol, and matrine, and stirring at 80 r/min for 5 min.
According to the weight portion, 3 portions of eucalyptol, 1 portion of menthol, 2 portions of trehalose, 0.5 portion of eugenol, 2 portions of zinc stearate, 23 portions of ethanol, 1.5 portions of konjac glucomannan, 0.4 portion of matrine and the balance of deionized water.
Example 4
Compared with example 3, the konjac glucomannan of example 4 is 1.2 parts, and other components and preparation conditions are the same.
Example 5
Compared with example 3, the konjac glucomannan of example 5 is 1 part, and other components and preparation conditions are the same.
Example 6
Compared with the example 3, the matrine of the example 6 is 0.2 part, and other components and preparation conditions are the same.
Comparative example 1
Compared with example 3, comparative example 1 has no matrine added, and other components and preparation conditions are the same.
Comparative example 2
Compared with example 3, comparative example 2 has no konjac glucomannan added, and other components and preparation conditions are the same.
And (3) performance testing:
(1) the repellent rate is as follows: the method comprises the steps of collecting larvae of aedes albopictus, breeding for 3 generations, selecting regular and healthy mosquitoes which emerge for 3-5d and do not suck blood, and testing by referring to a method in 'pesticide indoor efficacy test and evaluation for pesticide registration' (GB/T13917.9-2009). 120 healthy volunteers were selected and divided into 6 groups of 20. 4 x 4cm parts are exposed on the backs of two hands of the volunteers, the other parts are tightly wrapped, the mosquito repelling sprays obtained in the examples 3-6 and the comparative examples 1-2 are respectively sprayed on the test part of one hand of each group of volunteers, and the spraying amount is 0.2mL/cm 2 The other was used as a blank control; two arms are inserted into a mosquito cage filled with 100 aedes albopictus, the number of mosquitoes staying at an exposed part for sucking blood within 2min is recorded, the repellent rate =1- (the number of mosquito bites of a spray arm/the number of mosquito bites of a blank arm) is calculated by 100%, and the average value of all volunteers in each group is calculated; the repellency rate test is carried out after 60min, 120min, 180min and 240 min.
(2) The itching relieving effect is as follows: 120 healthy volunteers were selected and divided into 6 groups of 20. The part with the length of 4 multiplied by 4cm exposed out of the back of the two hands is stretched into a mosquito cage filled with 100 aedes albopictus, the mosquitoes are taken out after 2min, the mosquito repelling spray obtained in the embodiment 3-6 and the comparative example 1-2 is respectively sprayed on the biting part of one hand of each group of volunteers, and the spraying amount is 0.2mL/cm 2 The other hand was used as a blank control; and after 3h, questionnaire survey is carried out, the volunteers feel the itching conditions of the two hands at the moment, whether the itching relieving effect of the spraying arms is obvious or not is inquired compared with that of the blank arms, and the statistical number is recorded.
The data obtained are shown in Table 1.
Table 1:
Claims (9)
1. the long-acting mosquito-repelling itching-relieving spray comprises the following components of eucalyptol, menthol, trehalose, eugenol, stearate, ethanol and deionized water, and is characterized in that: the spray also comprises konjac glucomannan and matrine.
2. The long-acting mosquito-repelling itching-relieving spray according to claim 1 is characterized in that: the stearate is at least one of zinc stearate, calcium stearate and magnesium stearate.
3. The long-acting mosquito-repelling itching-relieving spray according to claim 1 is characterized in that: the weight portions of the components are 3 to 5 portions of eucalyptol, 1 to 2 portions of menthol, 1 to 2 portions of trehalose, 0.5 to 1 portion of eugenol, 1 to 3 portions of stearate, 22 to 23 portions of ethanol, 62.1 to 70.3 portions of deionized water, 1 to 1.5 portions of konjac glucomannan and 0.2 to 0.4 portion of matrine.
4. The preparation method of the long-acting mosquito-repelling itching-relieving spray disclosed by any one of claims 1 to 3 is characterized by comprising the following preparation steps of:
(1) preheating deionized water, adding konjac glucomannan, and stirring for one time until the mixture is transparent;
(2) adding menthol and stearate, and stirring for the second time;
(3) naturally cooling to room temperature, adding trehalose, and stirring for three times;
(4) adding eucalyptol, eugenol, ethanol, and matrine, and stirring for four times.
5. The preparation method of the long-acting mosquito-repelling itching-relieving spray according to claim 4 is characterized in that: in the step (1), the preheating temperature of the deionized water is 50-55 ℃.
6. The preparation method of the long-acting mosquito-repelling itching-relieving spray according to claim 4 is characterized in that: in the step (1), the rotation speed of primary stirring is 500-600r/min, and the time is not less than 1 h.
7. The preparation method of the long-acting mosquito-repelling itching-relieving spray according to claim 4 is characterized in that: in the step (2), the rotation speed of the secondary stirring is 200-250r/min, and the time is 20-30 min.
8. The preparation method of the long-acting mosquito-repelling itching-relieving spray according to claim 4 is characterized in that: in the step (3), the rotating speed of the three times of stirring is 200-250r/min, and the time is 5-10 min.
9. The preparation method of the long-acting mosquito-repelling itching-relieving spray according to claim 4 is characterized in that: in the step (4), the rotating speed of the four times of stirring is 50-80 r/min, and the time is 5-10 min.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424105A (en) * | 2002-12-31 | 2003-06-18 | 北京东方凯恩医药科技有限公司 | Medicinal spray |
| CN111053947A (en) * | 2019-12-03 | 2020-04-24 | 青岛职务帮网络服务有限公司 | Konjac glucomannan/fish gelatin hydrogel as well as preparation method and application thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424105A (en) * | 2002-12-31 | 2003-06-18 | 北京东方凯恩医药科技有限公司 | Medicinal spray |
| CN111053947A (en) * | 2019-12-03 | 2020-04-24 | 青岛职务帮网络服务有限公司 | Konjac glucomannan/fish gelatin hydrogel as well as preparation method and application thereof |
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