CN113476363A - Composition for repelling solenopsis invicta and application thereof - Google Patents
Composition for repelling solenopsis invicta and application thereof Download PDFInfo
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- CN113476363A CN113476363A CN202110733640.3A CN202110733640A CN113476363A CN 113476363 A CN113476363 A CN 113476363A CN 202110733640 A CN202110733640 A CN 202110733640A CN 113476363 A CN113476363 A CN 113476363A
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- Prior art keywords
- composition
- repelling
- pyrethrin
- solenopsis invicta
- azadirachtin
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- 239000000203 mixture Substances 0.000 title claims abstract description 81
- 230000001846 repelling effect Effects 0.000 title claims abstract description 43
- 241000736128 Solenopsis invicta Species 0.000 title claims abstract description 30
- VQXSOUPNOZTNAI-UHFFFAOYSA-N Pyrethrin I Natural products CC(=CC1CC1C(=O)OC2CC(=O)C(=C2C)CC=C/C=C)C VQXSOUPNOZTNAI-UHFFFAOYSA-N 0.000 claims abstract description 41
- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 claims abstract description 41
- VJFUPGQZSXIULQ-XIGJTORUSA-N pyrethrin II Chemical compound CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VJFUPGQZSXIULQ-XIGJTORUSA-N 0.000 claims abstract description 41
- 239000005878 Azadirachtin Substances 0.000 claims abstract description 27
- VEHPJKVTJQSSKL-UHFFFAOYSA-N azadirachtin Natural products O1C2(C)C(C3(C=COC3O3)O)CC3C21C1(C)C(O)C(OCC2(OC(C)=O)C(CC3OC(=O)C(C)=CC)OC(C)=O)C2C32COC(C(=O)OC)(O)C12 VEHPJKVTJQSSKL-UHFFFAOYSA-N 0.000 claims abstract description 27
- FTNJWQUOZFUQQJ-IRYYUVNJSA-N azadirachtin A Natural products C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C/C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-IRYYUVNJSA-N 0.000 claims abstract description 27
- FTNJWQUOZFUQQJ-NDAWSKJSSA-N azadirachtin A Chemical compound C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C\C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-NDAWSKJSSA-N 0.000 claims abstract description 27
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 23
- 239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 15
- 150000001412 amines Chemical class 0.000 claims abstract description 15
- 229920000570 polyether Polymers 0.000 claims abstract description 15
- 150000004668 long chain fatty acids Chemical class 0.000 claims abstract description 12
- NHOIBRJOQAYBJT-IMGVWCFESA-N nimbin Chemical compound C=1([C@@H]2C[C@H]3O[C@H]4[C@](C3=C2C)(C)[C@@H]([C@]2(C(=O)C=C[C@](C)([C@@H]2[C@H]4OC(C)=O)C(=O)OC)C)CC(=O)OC)C=COC=1 NHOIBRJOQAYBJT-IMGVWCFESA-N 0.000 claims abstract description 4
- ZQIYJHBQRBBBRZ-UHFFFAOYSA-N nimbin Natural products COC(=O)CC1C2C(C(OC(=O)C)C3OC4CC(C(=C4C13C)C)c5cocc5)C(C)(C=CC2=O)C(=O)OC ZQIYJHBQRBBBRZ-UHFFFAOYSA-N 0.000 claims abstract description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 24
- 239000002904 solvent Substances 0.000 claims description 23
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 21
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000012071 phase Substances 0.000 claims description 10
- 239000003381 stabilizer Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 8
- 239000008346 aqueous phase Substances 0.000 claims description 5
- 239000005639 Lauric acid Substances 0.000 claims description 4
- 241000257303 Hymenoptera Species 0.000 abstract description 35
- 230000000694 effects Effects 0.000 abstract description 19
- 239000005871 repellent Substances 0.000 abstract description 8
- 230000002940 repellent Effects 0.000 abstract description 8
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 239000000077 insect repellent Substances 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 description 24
- 230000000052 comparative effect Effects 0.000 description 11
- 239000007921 spray Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 7
- 239000004973 liquid crystal related substance Substances 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 241000517830 Solenopsis geminata Species 0.000 description 6
- 201000004624 Dermatitis Diseases 0.000 description 5
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- 230000000977 initiatory effect Effects 0.000 description 4
- 241000238631 Hexapoda Species 0.000 description 3
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- 241000748289 Solenopsis saevissima Species 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 239000000575 pesticide Substances 0.000 description 3
- 231100000611 venom Toxicity 0.000 description 3
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
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- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000002435 venom Substances 0.000 description 2
- 210000001048 venom Anatomy 0.000 description 2
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- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010040830 Skin discomfort Diseases 0.000 description 1
- 241001415041 Solenopsis richteri Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
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- 238000013329 compounding Methods 0.000 description 1
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- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
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- 230000014759 maintenance of location Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
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- 238000012544 monitoring process Methods 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the field of insect repellents, and particularly relates to a composition for repelling solenopsis invicta and application thereof. The composition comprises pyrethrin and azadirachtin; the mass ratio of the pyrethrin to the nimbin is (0.1-2.0) to (0.1-3.0); the total concentration of the pyrethrin and the azadirachtin in the composition is 0.2-5.0 wt%; also included are emulsifiers; the emulsifier is polyether amine and long-chain fatty acid. The composition can form very effective repelling aiming at the red imported fire ants; tests are carried out to meet the safety standard, and the product is nontoxic and harmless to human bodies in normal use; the short-term repellent effect of the solenopsis invicta reaches more than 99 percent.
Description
Technical Field
The invention belongs to the field of insect repellents, and particularly relates to a composition for repelling solenopsis invicta and application thereof.
Background
The red imported fire ant (the academic name: Solenopsis invicta Buren) belongs to the genus of fire ant, including five species of red imported fire ant, tropical imported fire ant, wood imported fire ant, black imported fire ant and Brazilian imported fire ant. The fire ant genus is generally strongly destructive, and the fire ant epidemic situation is easy to spread and spread, and the fire ant spreading epidemic situation has appeared in various countries and regions all over the world at present, so the fire ant control is reluctant.
Among them, the epidemic situation of red imported fire ants is particularly serious. By 3 months in 2021, according to the monitoring of agricultural rural departments, red imported fire ants have spread to 435 counties (cities and districts) in 12 provinces (districts and cities), particularly 191 county-level administrative areas where newly increased red imported fire ants occur in recent 5 years are doubled in 2016, and the red imported fire ants occur in green lands, farmlands, forest lands and other public areas in city parks.
The red imported fire ant has the capability of attacking and repeatedly stinging human bodies. It affects the health and quality of life of people at the site of intrusion, damages the utility electronics, and causes financial loss in communication, medical treatment, and pest control. Once the ant nest is disturbed, the red fire ants quickly come out of the nest to send out a strong attack behavior. The red fire ants clamp the skin of a person by using the palate, and the tail ends of the abdomens are used for continuously stinging the human body for many times, so that venom is released from the venom sac every time the human body stings. The human body is stinged by the red imported fire ants and feels painful as fire burns, and then blisters as burns appear. Most people only feel pain and uncomfortable, and few people are allergic to toxic protein in the venom, generate anaphylactic shock and have death risk.
Therefore, in case of a fire ant flood, the protection of the human body should be effective in addition to the killing. At present, 8 kinds of pesticide active ingredients with the effect of killing the red imported fire ants exist, 40 kinds of pesticide preparations exist, but spray preparations or applied emulsion and the like aiming at personal protection are not effectively developed, and the existing preparations have certain harm to human bodies.
Therefore, there is a need to develop a composition formulation that can achieve red fire ant repellency for personal protection.
Disclosure of Invention
The invention provides a composition for repelling red fire ants and application thereof, aiming at solving the problems that human bodies are easily bitten by the red fire ants during outdoor activities under the condition that the red fire ants are abused in various places at present and cannot be efficiently inhibited only by killing, and no preparation can effectively prevent and protect the red fire ants under the condition.
The invention aims to:
firstly, the safety and the effectiveness of the composition preparation are ensured, and the composition preparation is basically nontoxic to human bodies;
secondly, the effect of repelling the solenopsis invicta can be effectively realized, and the effective rate is over 95 percent;
and thirdly, the effective repelling of the red imported fire ants can be realized for a long time, and the effective duration is more than 4 h.
In order to achieve the purpose, the invention adopts the following technical scheme.
A composition for repelling Solenopsis invicta,
the composition comprises the following components:
pyrethrin and azadirachtin;
the mass ratio of the pyrethrin to the nimbin is (0.1-2.0) to (0.1-3.0);
the total concentration of the pyrethrin and the azadirachtin in the composition is 0.2-5.0 wt%.
In the technical scheme of the invention, pyrethrin and azadirachtin are key components for realizing the repelling of the red imported fire ants.
The pyrethrin is prepared into sanitary spray which can be used for household sanitary disinsection, and the pesticide prepared from the pyrethrin can be widely used for disinsection of economic crops such as green vegetables, green fruits, green tea leaves and the like. Studies have shown that the use of pyrethrin is not suitable for personal protection, since it is likely to cause dermatitis and even cause special allergy. Besides the insect expelling effect of the azadirachtin, the azadirachtin is generally considered to be harmless to human and livestock and widely applied to treatment of diarrhea, fever, rash, scald, incised wound, hypertension, jaundice, wound infection, leprosy, skin disease, gastric ulcer, varicella and other diseases, so that the azadirachtin and the pyrethrin are matched actually, and the azadirachtin can effectively inhibit and alleviate adverse reactions to human bodies when being used for personal protection.
Through the compounding of the two, a spray preparation or an emulsion preparation and the like are formed for the protection of the individual red imported fire ants, and the effect of insect pest repelling can be effectively realized. But generally, the total concentration of the two is less than or equal to 2.0 wt% to ensure the safety of the human body.
As a preference, the first and second liquid crystal compositions are,
the composition further comprises an emulsifier;
the emulsifier is polyether amine and long-chain fatty acid.
In the aforementioned proposal, the repelling of the red imported fire ants can be effectively achieved, but actually, the repelling cannot be kept effective for a long time. Therefore, the long-acting solenopsis invicta repellent effect of personal protection can be further realized through the improvement of other compound components. Such as by emulsifiers to improve the stability of pyrethrin and azadirachtin.
As a preference, the first and second liquid crystal compositions are,
the polyether amine is polyether amine D230 and/or polyether amine D400;
the long-chain fatty acid is capric acid and/or lauric acid.
The polyether amine and the long-chain fatty acid are matched to prepare a good emulsifier. However, the decanoic acid in a long chain fatty acid is specific to the present invention. Mainly because capric acid and polyether amine can form emulsified liquid drops with excellent amphipathy, in the actually prepared preparation, a water phase solvent or a solvent mainly comprising a water phase is selected, so that the effective coating of pyrethrin and azadirachtin can be realized, the volatilization of the pyrethrin and the azadirachtin can be inhibited to a certain extent, the onset time of the composition is prolonged, on the other hand, the emulsified liquid drops can effectively coat the pyrethrin, so that the pyrethrin can be prevented from damaging human bodies to a great extent, and the risk of the pyrethrin harming the human bodies is greatly reduced. Therefore, after the emulsifier prepared from the capric acid and the polyether amine is added into the composition, the dosage of the pyrethrin can be increased, and the long-acting prevention and the repellent of the red imported fire ants can be realized.
As a preference, the first and second liquid crystal compositions are,
the content of the emulsifier in the composition for repelling the solenopsis invicta is 0.5-2.0 wt%;
the mass ratio of the polyether amine to the long-chain fatty acid in the emulsifier is 1 (0.08-0.25) or 1 (0.8-1.1).
The dosage of the emulsifier is positively correlated with the dosage of the nimbin and the pyrethrin.
When the long-chain fatty acid is capric acid, the concentration of the long-chain fatty acid is extremely low, mainly because the long-chain fatty acid and the capric acid can form better emulsification and droplet assembly effects under the condition of low content actually, pyrethrin and azadirachtin are effectively coated, and on the other hand, targeted injury stimulation can be further realized by adopting the low-concentration capric acid, so that the influence of part of beneficial insects by the capric acid is avoided, and the pertinence of repelling is improved. Lauric acid does not have this characteristic, so that a higher amount can ensure a better emulsifying effect.
As a preference, the first and second liquid crystal compositions are,
the composition further comprises a stabilizer;
the stabilizer is 2, 6-di-tert-butyl-p-phenol;
the content of the stabilizer in the composition is 0.05-0.1 wt%.
The stabilizer can prolong the effective storage time of the composition and avoid the problems of precipitate and the like after long-time storage.
As a preference, the first and second liquid crystal compositions are,
the composition further comprises a solvent;
the solvent comprises an oil phase solvent and an aqueous phase solvent.
In order to be combined with the emulsifier, the solvent is required to ensure that the volume percentage of the aqueous phase solvent is more than 60%.
As a preference, the first and second liquid crystal compositions are,
the oil phase solvent is ethyl acetate;
the aqueous phase solvent is water.
The ethyl acetate is compatible with human bodies, basically has no toxicity and harm, is easy to decompose, has small molecular weight, and can form excellent emulsion drop assembly encapsulation effect of the pyrethrin and the azadirachtin by matching with the emulsifier.
As a preference, the first and second liquid crystal compositions are,
the solvent is composed of ethyl acetate, ethanol and water in a volume ratio of (15-25) to (70-80) of 5.
Through the tests, the use sense of the composition preparation in smearing or spraying can be improved by adopting a small amount of ethyl acetate and matching with ethanol, so that the composition preparation is more refreshing, and meanwhile, the excellent liquid drop encapsulation and assembly effects can be achieved.
The use of the composition is also disclosed,
the composition is used for personal protection and repelling solenopsis invicta.
The compositions of the present invention can be used more effectively for personal protection than the remaining pesticidal agents with biocidal properties.
The invention has the beneficial effects that:
1) can form very effective repelling for the red imported fire ants;
2) tests are carried out to meet the safety standard, and the product is nontoxic and harmless to human bodies in normal use;
3) the short-term repellent effect of the solenopsis invicta reaches more than 99 percent;
4) can realize the ultra-long-acting prevention and the repellent protection of the red imported fire ants for more than 12 hours.
Detailed Description
The present invention will be described in further detail with reference to specific examples. Those skilled in the art will be able to implement the invention based on these teachings. Moreover, the embodiments of the present invention described in the following description are generally only some embodiments of the present invention, and not all embodiments. Therefore, all other embodiments obtained by a person of ordinary skill in the art based on the embodiments of the present invention without any creative effort shall fall within the protection scope of the present invention.
Unless otherwise specified, the raw materials used in the examples of the present invention are all commercially available or available to those skilled in the art; unless otherwise specified, the methods used in the examples of the present invention are all those known to those skilled in the art.
Example 1
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
When the composition is prepared, the main effective component and the stabilizer are sequentially added into the solvent and uniformly mixed.
Example 2
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
When the composition is prepared, the main effective component and the stabilizer are sequentially added into the solvent and uniformly mixed.
Comparative example 1
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
When the composition is prepared, the main effective component and the stabilizer are sequentially added into the solvent and uniformly mixed.
Test I
The prepared composition was subjected to a solenopsis invicta repelling test, and a back-of-hand spray test with a spray bottle.
The red imported fire ant repelling test comprises the following steps: 100 solenopsis invicta taken as a group are placed in a transparent closed test box with the bottom surface of 36 multiplied by 36 cm, and air holes which cannot be passed by the solenopsis invicta are reserved at the top of the test box. Dividing the bottom part of the test box into three parallel, equal and parallel regions, wherein the area of each region is 12 multiplied by 36 cm, and the regions are an invalid region, a weak region and a strong region in sequence;
the composition preparation prepared by dripping 2 drops of the composition preparation on the edge part of the ineffective area far away from the strong area is automatically shot and recorded by an automatic timing photographic device, one picture is shot every 2 min, the average value of the number of the red fire ants in each area in 30 pictures is recorded by taking 1 h as a unit, 4 h is recorded, and a blank control group (the composition is replaced by deionized water) is used as a control.
In the hand back spray test, total 60 volunteers of 18-25 years old are selected to be divided into four groups, double-blind test is carried out, the period is 15 d, each volunteer carries out three-time spray in the morning, the noon and the evening on the back of the left hand every day, and whether dermatitis or allergy is generated is recorded.
The results are shown in the following table.
| Test group | Mean number of dead zones | Mean number of weak zones | Mean of robust region | Skin conditions |
| Example 1 test group | 0.375 | 3.008 | 96.617 | No symptoms |
| Example 2 test group | 0.058 | 1.625 | 98.317 | No symptoms |
| Comparative example 1 test group | 0.041 | 1.541 | 98.418 | 1 mild dermatitis |
| Blank control group | 33.475 | 34.733 | 31.792 | No symptoms |
It is clear that the mean of the three zones of the placebo group is essentially equivalent and completely ineffective, but the test group portion produced a clear distinction, proving to be effective. Therefore, the effect proportion of the test group is calculated by the following specific calculation method: inefficiency = mean number of null sectors/100 × 100%, efficiency = (mean number of weak sectors + mean number of strong sectors)/100 × 100%, strong efficiency = mean number of strong sectors/100 × 100%.
The calculation of the inefficiency, efficiency and efficiency from the above table is shown in the following table.
| Test group | Inefficiency of | High efficiency | High efficiency |
| Example 1 test group | 0.375% | 99.625% | 96.617% |
| Example 2 test group | 0.058% | 99.942% | 98.317% |
| Comparative example 1 test group | 0.041% | 99.959% | 98.418% |
It can be seen that the actual effective rate and the strong efficiency are both almost in positive correlation with the pyrethrin and azadirachtin contents, but it is also evident from the test group of comparative example 1 that in case of too high pyrethrin and azadirachtin contents, especially, too high pyrethrin contents, one volunteer showed a mild dermatitis symptom and recovered after about 2 days.
Example 3
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
When the composition is prepared, firstly, the pyrethrin, the azadirachtin and the 2, 6-di-tert-butyl-p-phenol are added into ethyl acetate to prepare oil phase liquid, the emulsifier is added into deionized water to prepare water phase liquid, the oil phase liquid and the water phase liquid are mixed, and the mixture is stirred at 500 rpm for 15 min to complete the preparation of the composition.
Example 4
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
Test II
The same tests as test I were carried out for examples 3 and 4 above and compared with example 2.
The efficiencies of 4 h, 6 h, 8 h, 10 h and 12 h were recorded. The records are shown in the following table.
As is evident from the data in the above table, the initial effect (effective rate of 4 h) is reduced to some extent after the emulsifier is added, but the reduction of the example 4 test group is smaller and can be basically ignored compared with the example 3 test group, which indicates that the initial effect of lauric acid on the composition is weaker compared with capric acid. It can be seen from the long-term comparison that the effective rate of the test group in example 2 decreases rapidly with the time, the effective rate decreases to about 72% at 12 h, which is only 72.1% compared with the initial effect, and the effective rate of the test group in example 4 decreases to about 79% at 12 h, which is 78.9% compared with the initial effect. However, in the test group of example 3, the effective rate of the test group is still approximately 90% after 12 h, compared with the initial effective retention of 89.8%.
Obviously, the addition of the decanoic acid can effectively realize the long-acting slow release of the pyrethrin and the azadirachtin, effectively prolong the effective time, and basically achieve the effect of 12 hours by taking 90 percent of effective rate as a limit.
Example 5
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
Example 6
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
The compositions of examples 5 and 6 were tested for effectiveness for 12 hours according to the same test method as test I. The test result shows that the 12 h effective rate of the test group in example 5 is 92.493%, and the 12 h effective rate of the test group in example 6 is 82.101%.
It can be seen that the amount of emulsifier used can affect the long-acting (12 h) effectiveness of the composition to some extent, and both are substantially positively correlated.
Example 7
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
Comparative example 2
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
Comparative example 3
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
The compositions of example 7, comparative example 2 and comparative example 3 were subjected to a back-of-hand spray test in which the volunteers of the test groups of example 7 and comparative example 3 did not exhibit significant symptoms of skin discomfort, the test group of comparative example 2 exhibited symptoms of mild dermatitis, recovered after 1 day, and three of the test groups exhibited symptoms of mild itching.
It can be basically seen from the above tests that pyrethrin does have a slight effect on human skin. However, the slow release can be effectively realized by adding the capric acid emulsifier, and the influence of the pyrethrin on human body is reduced. With the above-mentioned test groups added, the pyrethrin content of 2.0 wt.% essentially reaches the harmless critical point, above which there is a risk of damage to the skin of the user.
And the effect cannot be further obviously improved even if the dosages of the pyrethrin and the azadirachtin are further increased, so that the actual optimal dosages of the pyrethrin and the azadirachtin are both 0.1-1.0 wt% under the condition of not adding an emulsifier, and the maximum dosages can be increased to 2.0 wt% and 3.0 wt% under the condition of adding a capric acid/polyether amine emulsifier.
Example 8
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
Example 9
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
Example 10
The specific components and mass percentages of the composition for repelling the red imported fire ants are shown in the following table.
The preparation method is the same as example 3.
Using the compositions obtained in the test groups of examples 8 to 10, the same tests as in test II were carried out and compared with the data of example 3, as shown in the following table.
From the above test groups, it is obvious that, under the condition of changing the solvent system, the addition of ethanol can produce certain influence on the long-acting effective rate of the composition, and especially when the volume percentage of ethanol in the solvent is about 20% VOL, the long-acting effective rate is remarkably improved by about 2.7%.
It is obvious from the combination of the above examples and comparative test groups that pyrethrin and azadirachtin are the most effective components in the technical scheme of the invention. The effective repellent has a very good effect of repelling the red imported fire ants in a short time, controls the content of the pyrethrin and the azadirachtin, and can effectively avoid the adverse effect of the pyrethrin on human bodies. The long-acting repellent effect can be effectively realized by adding the emulsifier, and the long-acting slow release of the pyrethrin and the azadirachtin can be realized mainly because the emulsion droplets encapsulate the pyrethrin and the azadirachtin to a certain extent, so that when the microemulsion is used for a human body protection spray preparation, the adverse effect of the pyrethrin on a human body can be reduced or even almost completely avoided, the using amounts of the pyrethrin and the azadirachtin can be increased, and the repellent effect is further improved.
Claims (9)
1. A composition for repelling solenopsis invicta is characterized in that,
the composition comprises the following components:
pyrethrin and azadirachtin;
the mass ratio of the pyrethrin to the nimbin is (0.1-2.0) to (0.1-3.0);
the total concentration of the pyrethrin and the azadirachtin in the composition is 0.2-5.0 wt%.
2. The composition for repelling solenopsis invicta according to claim 1,
the composition further comprises an emulsifier;
the emulsifier is polyether amine and long-chain fatty acid.
3. The composition for repelling solenopsis invicta according to claim 2,
the polyether amine is polyether amine D230 and/or polyether amine D400;
the long-chain fatty acid is capric acid and/or lauric acid.
4. The composition for repelling solenopsis invicta as claimed in claim 2 or 3,
the content of the emulsifier in the composition for repelling the solenopsis invicta is 0.5-2.0 wt%;
the mass ratio of the polyether amine to the long-chain fatty acid in the emulsifier is 1 (0.08-0.25) or 1 (0.8-1.1).
5. The composition for repelling solenopsis invicta according to claim 1,
the composition further comprises a stabilizer;
the stabilizer is 2, 6-di-tert-butyl-p-phenol;
the content of the stabilizer in the composition is 0.05-0.1 wt%.
6. The composition for repelling solenopsis invicta according to claim 1,
the composition further comprises a solvent;
the solvent comprises an oil phase solvent and an aqueous phase solvent.
7. The composition for repelling solenopsis invicta according to claim 6,
the oil phase solvent is ethyl acetate;
the aqueous phase solvent is water.
8. The composition for repelling solenopsis invicta as claimed in claim 6 or 7,
the solvent is composed of ethyl acetate, ethanol and water in a volume ratio of (15-25) to (70-80) of 5.
9. Use of a composition according to any of claims 1 to 9,
the composition is used for personal protection and repelling solenopsis invicta.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116649338A (en) * | 2023-05-31 | 2023-08-29 | 华南农业大学 | Formica rupestris repellent and application thereof |
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