KR101167068B1 - Rodent Repellent Composition - Google Patents

Abstract

The present invention is 0.1 to 5% by weight capsaicin extract; 0.1-10% by weight of bark extract; 0.01-2% by weight of pine essential oil; 0.1 to 2% by weight sodium monofluorophosphate; 50 to 80 weight percent thickener; 0.1-2% by weight of an ultraviolet absorbent; And 10 to 40% by weight of a stabilizer.

The rodent repellent composition according to the present invention has an effect of providing a repellent learning effect by inducing a synergistic effect by formulating a complex formulation of environmentally friendly natural rodent repellent compositions in a complex manner.

Description

Rodent Repellent Composition

The present invention relates to a rodent repellent composition, and more particularly, to a rodent repellent composition capable of dissipating the odors avoided by rodents, allowing the rodents to block access.

Rodents are harmful animals that carry various diseases or cause great damage to growing crops or stocks. They are widely distributed around the world, and there are more than 1,800 species. Hereinafter, for convenience of description, the present invention will be described with reference to rats, which are the most problematic of rodents.

In the past few decades, the insecticide has been used, and the problem of human toxicity is serious, causing a lot of problems in handling, so far has not been very successful in rodent rescue, rats predatory raptors and snakes, such as pollution and overfishing Increasingly, as they disappeared, they reached their limit in reducing the density of soaring mice.

Therefore, the repellent against rats is of interest in forestry and agriculture, and the necessity of repellent against rats is increasing for the protection of goods and the safety of information and communication networks due to the surge in trade and information transport.

Previously developed rat repellents have been developed such as thiram, cycloheximide and tributyltin salts, some of which have been shown to be detrimental to stocking, and the most widely used cycloheximide is expensive and somewhat contaminated. It is known to have enemy elements.

Accordingly, in recent years, interest in non-harmful insecticides and repellents of non-target animals extracted from natural materials has been increasing. For example, Korean Patent Application Laid-Open No. 1998-075927 uses natural substances to suppress harmful rodents. A method for preparing a microbiological killing agent is disclosed. However, this has a problem of causing high pathogenicity and toxicity to rats and causing lethal epidemics.

An object of the present invention for solving the problems of the prior art as described above may be to formulate a complex environmentally friendly natural rodent repellent composition in combination to provide a remarkable synergistic effect to provide the repellent effect to the peak to provide a repellent learning effect There is provided a rodent repellent composition.

In addition, another object of the present invention to provide a rodent repellent composition comprising a pine essential oil having a high repellent activity against rodents.

The present invention to achieve the above object is 0.1 to 5% by weight of capsaicin extract; 0.1-10% by weight of bark extract; 0.01-2% by weight of pine essential oil; 0.1 to 2% by weight sodium monofluorophosphate; 50 to 80 weight percent thickener; 0.1-2% by weight of an ultraviolet absorbent; And it provides a rodent repellent composition, characterized in that it comprises a 10 to 40% by weight stabilizer.

In addition, the thickener provides a rodent repellent composition, characterized in that the polybutene.

In addition, the ultraviolet absorbent provides a rodent repellent composition, characterized in that the benzotriazole-based.

In addition, the stabilizer provides a rodent repellent composition, characterized in that the grease (Grease).

The rodent repellent composition according to the present invention has an effect of inducing a remarkable synergy by formulating a complex environment-friendly natural rodent repellent composition in combination, leading to the highest repellent effect on rodents.

Hereinafter, the rodent repellent composition according to a preferred embodiment of the present invention will be described in more detail.

The rodent repellent composition according to the present invention comprises a main component consisting of capsaicin extract, bark tree extract, sodium monofluorophosphate, pine essential oil and thickener, and a subcomponent consisting of an ultraviolet absorber and a stabilizer.

Capsaicin, one of the main components of the present invention, is a red pepper extract, and the fragrance is a dark red liquid with a red pepper flavor. Capsaicin is used as a pesticide registered in the US EPA. Capsaicin extract is commercialized as an algae repellent, but generally known to be effective when ingested.

The capsaicin extract is used at 0.1 to 5% by weight, preferably 1 to 3% by weight of the total composition. When capsaicin extract is used in less than 0.1% by weight of the total composition does not exhibit rodent repellent effect, when used in excess of 5% by weight is difficult to handle due to the irritating aroma.

In the present invention, the rodent repellent composition was completed in combination with other main ingredients in order to maximize the effect of stimulating the eyes or nasal mucosa as a repellent using aroma rather than a repellent using ingestion.

One of the main components of the present invention, the extract of the bark tree has an excellent effect in chasing animals that have become resistant to spicy ingredients such as capsaicin, and is known to be effective in other animals besides rodents.

In addition, the bark extract has the advantage of strong initial stimulation like capsaicin, and also has antibacterial, antifungal, antioxidant and antiviral effects, and repelling effect on pests, thus preventing damage or rot after pests are installed. Can be used to do so.

The bark wood is used at 0.1 to 10% by weight, preferably 5 to 10% by weight of the total composition. At this time, when the bark extract is used in less than 0.1% by weight of the total composition of the antimicrobial, antifungal, antioxidant and antiviral effect is reduced, the effect of the composition may be reduced, if the content exceeds 10% by weight viscosity problem May be caused.

Sodium monofluorophosphate, one of the main components of the present invention, is a substance mainly used in toothpaste, and is mainly used for preventing tooth decay, but is also used as an insecticide. It also contains components that stimulate nerves in rodents, and may exhibit repelling effects due to stimulating effects.

The sodium monofluorophosphate is used in 2% by weight, preferably within 1% by weight of 2% by total of the total composition. At this time, when sodium monofluorophosphate is used in less than 0.1% by weight of the total weight of the composition, the nerve stimulation effect may be reduced, and when it exceeds 2% by weight, it may not be mixed with other compositions and may not significantly affect the nerve stimulation effect. Can be.

Pine essential oil, which is one of the main components of the present invention, is also used as an inexpensive phenolic disinfectant, and plant essential oils such as pine essential oil have little or no adverse effects on non-target microorganisms and the environment, and act selectively. . It is also toxic to pests, but is known to be safe enough to be used as an ingredient in perfumes, fragrances, and cosmetics. Some of these vegetable essential oils are acutely toxic, while others are repellent-induced, spawning inhibitory, It is known to have an effect.

The virulence mechanisms of vegetable essential oils are not yet known, but the onset of symptoms is rapid, accompanied by agitation, hyper-activity, and rapid knock-down. Moreover, most vegetable essential oils are non-toxic to mammals and in general many vegetable essential oils are known to be safe by the U.S. Food and Drug Administration. In addition, these vegetable essential oils have been reported to be used as insect control agents that are toxic to insects.

The inventors of the present invention, while investigating the repellent activity of vegetable essential oils for rodents, confirmed that pine essential oils have a repelling power against rodents in vegetable essential oils.

Pine essential oil contains terpene alcohols as the main active ingredient, and has excellent antibacterial and antifungal effects and repellent effect against pests. After installation of rodent repellents, it is possible to prevent surface contamination and decay of the composition by pests. It can also be useful for prevention.

The pine essential oil is used at 0.01 to 2% by weight, preferably 0.1 to 1% by weight of the total weight of the total composition. In this case, when the pine essential oil is used in less than 0.01% by weight of the total composition, the antimicrobial and antifungal effects may be reduced, resulting in contamination by bacteria and fungi of the composition, and other strong aromas may cause the fragrance of the product itself. And when the pine essential oil is more than 2% by weight of the total composition, not only the viscosity decreases, but also the repellent of the fragrance is reduced, the effectiveness of the rodent repellent may be reduced.

Thickeners, which are one of the main components of the present invention, are used in 50 to 80% by weight, preferably 60 to 70% by weight of the total weight of the total composition. At this time, when the thickener is used in less than 50% by weight of the total weight of the composition, the viscosity may be reduced to reduce the rodent repellent effect due to tactile feeling, and when used in excess of 80% by weight, denaturation and the combined effect with other main components are reduced. Can cause.

In the present invention, polybutene may be used as the thickener. Polybutene is a polymer of isobutene (high molecular weight and low content) is mixed. This polybutene is a thickener registered as a food additive in the US FDA and EPA, and is known to stimulate tactile sensation by stickiness.

The ultraviolet absorber, which is one of the sub-components of the present invention, may cause a memory for unpleasantness in rodents when ingested or in contact, thereby maximizing the avoidance of the area.

The ultraviolet absorber is used at 0.1 to 2% by weight, preferably 0.5 to 1% by weight of the total weight of the total composition. When the ultraviolet absorber is used in less than 0.1% by weight of the total composition is less discolored effect on the light, even if used in excess of 2% by weight does not significantly increase the repellent effect.

In the present invention, as the ultraviolet absorber, a benzotriazole-based resin having a relatively low cost, excellent solubility, and low toxicity may be used.

Stabilizers, which are submaterials of the present invention, are used at 10 to 40% by weight, preferably 15 to 20% by weight of the total weight of the total composition. At this time, if the stabilizer is used in less than 10% by weight of the total weight of the composition, the film formation may be unstable, resulting in loss of the composition.If the stabilizer is used in excess of 40% by weight, the viscosity of the composition decreases, thereby reducing the rodent avoidance effect. May be caused.

In the present invention, the stabilizer uses grease, and the grease forms an oil film on the surface of the rodent repellent composition, so that moisture penetrates into the rodent repellent composition in areas with high moisture such as snow or boiling, resulting in the loss of main components in the rodent repellent. By preventing denaturation, it maintains the stability of the rodent repellent composition to act to sustain the repelling effect.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the present invention is not limited to these examples.

Example 1 Preparation of Rodent Repellent Composition

Sodium monofluorophosphate, vinewood extract (barberry alcohol extract) and capsaicin extract were put in a mixer and mixed evenly, and then mixed again by adding a thickener (polybutene) and a UV absorber (Ciba TINUVIN 99-2). Finally, grease and pine essential oil were mixed to prepare a rodent repellent composition. At this time, the content of each component 2% by weight of sodium monofluorophosphate, 7% by weight of bark tree extract, 1% by weight of capsaicin extract, 70% by weight thickener, 1% by weight of UV absorber, 18% by weight of grease, 1% by weight of pine essential oil Was used.

Example 2 Preparation of Rodent Repellent Composition

In Example 1, a rodent repellent composition was prepared in the same manner as in Example 1, except that 14% by weight of the extract of bark tree, 2% by weight of capsaicin extract, 60% by weight of thickener and 20% by weight of grease were used.

Example 3 Preparation of Rodent Repellent Composition

In Example 1, rodent repellent composition was prepared in the same manner as in Example 1, except that 21% by weight of the bark extract, 3% by weight of capsaicin extract, 50% by weight of thickener and 22% by weight of grease were used.

Experimental Example 1 Rodent Repelling Effect According to Rodent Repellent Composition

In order to evaluate the rodent repellent effect of the rodent repellent composition prepared according to the Example, SPF ICR mice (n = 15) were distributed in Oriental Co., Ltd. to confirm the rodent repellent effect on a laboratory scale.

Under laboratory conditions, feed was placed in half of the mouse cage, and rodent repellent compositions prepared according to Examples 1, 2, and 3 were applied to the remaining half of the cage at high doses (10 g) and low doses (1 g), respectively. Feed intake was measured for 1 week .

1, 2, and 3 of the graphs of FIG. 1 show that feed intake is reduced more than that of FIGS. 2 and 3, and the efficacy period is confirmed to be continued. In the case of Figure 1 Example 1 in the experimental group coated with a rodent repellent composition at a high dose (10 g) of the mouse intestine was not ingested at all of the feed portion of the coated portion, the feed was ingested normally I could confirm that. In addition, the experimental group applied a low dose (1 g) of rodent repellent composition to half of the mouse iron rod, although it was intermittently ingested, it was judged that almost no feed was ingested. Could.

In the group to which the high dose (10 g) rodent repellent composition was applied, the hair roots of the mice are maintained for a week and cause eye irritation, so it is necessary to reset the amount of the high dose, and the low dose (1 g) rodent In the group to which the repellent composition was applied, hair root standing phenomena disappeared after 4 days, and there was no eye swelling.

Experimental Example 2 Evaluation of Efficacy on Rodents According to Rodent Repellent Composition

1. Experimental Method

1) animals

 ICR mice (male n = 60) of the SIC: ICR strains were used to confirm rodent evasion effects at the laboratory scale. ICR mice have been used as a target animal because there are many research results so that it is advantageous to compare and interpret the results.

2) Breeding environment

Conventional systems equipped with HEPA filters were used for testing in healthy individuals in cages (IVC, MVS24P, Threeshine Co., Ltd.) equipped with HEPA filters in an air-conditioned room where constant temperature and humidity were maintained. Feed and negative water were fed free, and the experimental group was set as shown in [Table 1] below.

[Table 1]

3) Evaluation of efficacy on rodent repellent compositions

In order to confirm the repellent effect of the rodent repellent composition prepared according to Examples 1, 2, and 3, a video camera (SDVR-4300, NADATEL, Korea) was used for 24 hours after a 1-week purifying period under laboratory conditions. , Behavioral abnormalities of mice were observed and feed intake was measured. The rodent repellent composition prepared according to Examples 1, 2, and 3 was applied to mouse cages at high doses (5 g), medium doses (2.5 g) and low doses (1 g), and exposed for 28 days. The adaptation of the was confirmed. When the high dose (10 g) was used in Experimental Example 1, the high dose was changed to 5 g. The presence or absence of gross behavioral abnormalities in rodents due to contact and exposure of the test substance was determined to be far away from the scrub, head shaking, hair root standing and contact.

2. Experimental results

As shown in Figure 4, 5, 6, Figure 4 was confirmed that the feed intake reduced the most than Figure 5, 6, it was confirmed that the efficacy period is also long. In FIG. 4, even when the mouse was exposed to the rodent repellent composition for a long time (28 days), it was confirmed that the feed intake was reduced in the rodent repellent composition applied at a high dose (5 g), and even in the rodent repellent composition applied at the medium dose (2.5 g). Initially, feed intake decreased, but after 14 days, there was no rapid decrease in feed intake as before 14 days, but it was found to be reduced compared to the control. The feed intake of the rodent repellent composition applied at a low dose (1 g) was also compared to the control. It can be observed that after 14 days, the same result as the control group was consumed after 14 days, and the treatment was continued after 14 days when the treatment was performed at a medium dose (2.5 g) or more.

In addition, mice exposed to the high dose (5 g) rodent repellent composition did not attempt to approach near the iron rod, as shown in Figure 7, the subjects in contact with the rodent repellent composition, such as squat, stir, hair shaking, hair root erection Abnormal behavior was shown.

While the invention has been described in detail in the foregoing embodiments, it will be apparent to those skilled in the art that various modifications and variations are possible within the spirit of the invention, and such modifications and variations belong to the appended claims.

1 is a graph showing the results of measuring feed intake for one week after high dose application (10 g), low dose application (1 g) and no addition (control) of the rodent repellent composition according to Example 1 to the feed.

Figure 2 is a graph showing the results of measuring feed intake for one week after high dose application (10 g), low dose application (1 g) and no addition (control) of the rodent repellent composition according to Example 2 to the feed.

3 is a graph showing the results of measuring feed intake for one week after high dose application (10 g), low dose application (1 g) and no addition (control) of the rodent repellent composition according to Example 3 to the feed.

4 is a 28-day feed when the rodent repellent composition according to Example 1 is placed in front of a cage after high dose application (5 g), medium dose application (2.5 g), low dose application (1 g) and no addition (control) It is a graph of the measurement of intake.

5 is a 28-day feed when the rodent repellent composition according to Example 2 is placed in front of a cage after high dose application (5 g), medium dose application (2.5 g) low dose application (1 g) and no addition (control) It is a graph of the measurement of intake.

6 is a 28-day feed when the rodent repellent composition according to Example 3 is placed in front of a cage after high dose application (5 g), medium dose application (2.5 g) low dose application (1 g) and no addition (control) It is a graph of the measurement of intake.

 Figure 7 is a photograph of the behavioral abnormalities of the rat according to the use of rodent repellent when the rodent repellent composition according to Example 1 was treated for 28 days at a high dose (5 g).

Claims (4)

0.1-5% by weight of capsaicin extract; 0.1-10% by weight of bark extract; 0.01-2% by weight of pine essential oil; 0.1 to 2% by weight sodium monofluorophosphate; 50 to 80 weight percent thickener; 0.1-2% by weight of an ultraviolet absorbent; And A rodent repellent composition, comprising 10 to 40 weight percent stabilizer. The method of claim 1, The thickener is a rodent repellent composition, characterized in that the polybutene. The method of claim 1, The rodent repellent composition, characterized in that the ultraviolet absorber is benzotriazole-based. The method of claim 1, The stabilizer is a rodent repellent composition, characterized in that the grease (Grease).

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