CN114806218A - 超亮二聚或多聚染料 - Google Patents
超亮二聚或多聚染料 Download PDFInfo
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- CN114806218A CN114806218A CN202210616586.9A CN202210616586A CN114806218A CN 114806218 A CN114806218 A CN 114806218A CN 202210616586 A CN202210616586 A CN 202210616586A CN 114806218 A CN114806218 A CN 114806218A
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/109—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing other specific dyes
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/101—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye
- C09B69/102—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye containing a perylene dye
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/103—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a diaryl- or triarylmethane dye
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317192P | 2016-04-01 | 2016-04-01 | |
| US62/317,192 | 2016-04-01 | ||
| PCT/US2017/025530 WO2017173355A1 (en) | 2016-04-01 | 2017-03-31 | Ultra bright dimeric or polymeric dyes |
| CN201780000667.3A CN107580618A (zh) | 2016-04-01 | 2017-03-31 | 超亮二聚或多聚染料 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780000667.3A Division CN107580618A (zh) | 2016-04-01 | 2017-03-31 | 超亮二聚或多聚染料 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114806218A true CN114806218A (zh) | 2022-07-29 |
Family
ID=58609995
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210616586.9A Pending CN114806218A (zh) | 2016-04-01 | 2017-03-31 | 超亮二聚或多聚染料 |
| CN201780000667.3A Pending CN107580618A (zh) | 2016-04-01 | 2017-03-31 | 超亮二聚或多聚染料 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780000667.3A Pending CN107580618A (zh) | 2016-04-01 | 2017-03-31 | 超亮二聚或多聚染料 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11142647B2 (https=) |
| EP (1) | EP3436529A1 (https=) |
| JP (1) | JP7049113B2 (https=) |
| KR (3) | KR102773661B1 (https=) |
| CN (2) | CN114806218A (https=) |
| AU (1) | AU2017240154B2 (https=) |
| BR (1) | BR112018070164B1 (https=) |
| CA (2) | CA3231845A1 (https=) |
| RU (1) | RU2762328C2 (https=) |
| WO (1) | WO2017173355A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| JP6806694B2 (ja) | 2015-02-26 | 2021-01-06 | ソニー株式会社 | 共役基を含む水溶性蛍光染料または有色染料 |
| JP6982500B2 (ja) | 2015-02-26 | 2021-12-17 | ソニーグループ株式会社 | フェニルエチニルナフタレン染料およびそれらの使用方法 |
| US10865310B2 (en) | 2015-05-11 | 2020-12-15 | Sony Corporation Of America | Ultra bright dimeric or polymeric dyes |
| AU2017240154B2 (en) * | 2016-04-01 | 2021-08-12 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US11434377B2 (en) | 2016-04-01 | 2022-09-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| US9851359B2 (en) | 2016-04-06 | 2017-12-26 | Sony Corporation Of America | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| US11370922B2 (en) | 2016-05-10 | 2022-06-28 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| WO2017197014A2 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| KR102526802B1 (ko) | 2016-05-11 | 2023-05-02 | 소니그룹주식회사 | 초고명도 이량체성 또는 중합체성 염료 |
| WO2017214165A1 (en) | 2016-06-06 | 2017-12-14 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
| JP7312929B2 (ja) | 2016-07-29 | 2023-07-24 | ソニーグループ株式会社 | 超明色二量体またはポリマー色素およびその調製のための方法 |
| JP7270254B2 (ja) | 2017-06-16 | 2023-05-10 | デューク ユニバーシティ | 改善された標識検出、演算、検体感知、および調整可能な乱数生成のための共鳴体ネットワーク |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| CN111093711A (zh) | 2017-10-05 | 2020-05-01 | 索尼公司 | 可编程的树枝状药物 |
| CN111836645A (zh) * | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| CN111565756A (zh) | 2018-01-12 | 2020-08-21 | 索尼公司 | 包含生物活性化合物的具有刚性间隔基团的聚合物 |
| US12194104B2 (en) | 2018-01-12 | 2025-01-14 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| EP3737419B1 (en) * | 2018-01-12 | 2024-04-10 | Sony Group Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| KR102864292B1 (ko) | 2018-03-21 | 2025-09-26 | 소니그룹주식회사 | 링커 군을 갖는 중합체성 텐덤 염료 |
| CN119220109A (zh) | 2018-03-30 | 2024-12-31 | 贝克顿·迪金森公司 | 含侧基发色团的水溶性聚合染料 |
| US12006438B2 (en) | 2018-06-27 | 2024-06-11 | Sony Group Corporation | Polymeric dyes with linker groups comprising deoxyribose |
| EP3820944A1 (en) * | 2018-07-13 | 2021-05-19 | Sony Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| US20220160887A1 (en) * | 2019-04-11 | 2022-05-26 | Sony Group Corporation | Programmable polymeric drugs |
| WO2021062176A2 (en) | 2019-09-26 | 2021-04-01 | Sony Corporation | Polymeric tandem dyes with linker groups |
| EP4038081A1 (en) | 2019-09-30 | 2022-08-10 | Sony Group Corporation | Nucleotide probes |
| EP4251764A1 (en) * | 2020-11-25 | 2023-10-04 | Sony Group Corporation | Polymer dyes |
| WO2022125564A1 (en) | 2020-12-07 | 2022-06-16 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| WO2022216450A1 (en) | 2021-04-07 | 2022-10-13 | Becton, Dickinson And Company | Water-soluble fluorescent polymeric dyes |
| KR20250023376A (ko) | 2022-06-15 | 2025-02-18 | 소니그룹주식회사 | 스페이싱 링커 그룹을 갖는 중합체 탠덤 염료 |
| WO2023242662A2 (en) | 2022-06-15 | 2023-12-21 | Sony Group Corporation | Polymeric tandem dyes with spacing linker groups |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006020947A2 (en) * | 2004-08-13 | 2006-02-23 | Epoch Biosciences, Inc. | Phosphonate fluorescent dyes and conjugates |
| EP2366785A1 (en) * | 2008-11-14 | 2011-09-21 | Japan Science And Technology Agency | Oligonucleotide derivative, labeling agent, and use of the labeling agent |
| CN105377994A (zh) * | 2013-08-22 | 2016-03-02 | 索尼公司 | 水溶性荧光染料或有色染料及其使用方法 |
Family Cites Families (184)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450305A (en) | 1982-10-25 | 1984-05-22 | American Cyanamid Company | Poly(ethyleneoxy)-substituted-9,10-bis(phenylethynyl)anthracenes |
| US4476229A (en) | 1982-11-08 | 1984-10-09 | Abbott Laboratories | Substituted carboxyfluoresceins |
| SU1121931A1 (ru) * | 1983-01-10 | 1988-04-15 | Институт Биологической Химии Ан Бсср | Конъюгаты тиреоидных гормонов с альбумином дл выработки антител к тиреоидным гормонам у животных |
| EP0355864A3 (en) | 1984-03-15 | 1991-09-18 | Wako Pure Chemical Industries, Ltd. | Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter |
| JPH0665677B2 (ja) | 1985-03-09 | 1994-08-24 | 三菱化成株式会社 | リン脂質類似構造を有するジオ−ルおよびその製造方法 |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5053054A (en) | 1988-09-12 | 1991-10-01 | Ortho Pharmaceutical Corporation | Methods and reagents for staining intracellular components |
| US5318894A (en) | 1990-01-30 | 1994-06-07 | Miles Inc. | Composition, device and method of assaying for peroxidatively active substances |
| US6365730B1 (en) | 1990-06-19 | 2002-04-02 | Gene Shears Pty. Limited | DNA-Armed ribozymes and minizymes |
| JPH04282391A (ja) | 1991-03-08 | 1992-10-07 | Fujisawa Pharmaceut Co Ltd | エタノールアミン誘導体およびその製造法 |
| US5698391A (en) | 1991-08-23 | 1997-12-16 | Isis Pharmaceuticals, Inc. | Methods for synthetic unrandomization of oligomer fragments |
| WO1993006482A1 (en) | 1991-09-16 | 1993-04-01 | Molecular Probes, Inc. | Dimers of unsymmetrical cyanine dyes |
| EP1067134B1 (en) | 1991-11-07 | 2004-07-28 | Nanotronics, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| WO1994024120A1 (en) | 1993-04-13 | 1994-10-27 | Naxcor | Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents |
| WO1995002700A1 (en) | 1993-07-13 | 1995-01-26 | Abbott Laboratories | Fluorescent polymer labeled conjugates and intermediates |
| WO1995006731A2 (en) | 1993-09-02 | 1995-03-09 | Ribozyme Pharmaceuticals, Inc. | Non-nucleotide containing enzymatic nucleic acid |
| US5886177A (en) | 1994-01-11 | 1999-03-23 | Isis Pharmaceuticals, Inc. | Phosphate linked oligomers |
| US6171859B1 (en) | 1994-03-30 | 2001-01-09 | Mitokor | Method of targeting conjugate molecules to mitochondria |
| US5994143A (en) | 1996-02-01 | 1999-11-30 | Abbott Laboratories | Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment |
| US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
| DE19633268A1 (de) | 1996-08-19 | 1998-02-26 | Hoechst Ag | Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung |
| US5696157A (en) | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
| JP2001511128A (ja) | 1997-01-28 | 2001-08-07 | ファルマシア・アンド・アップジョン・カンパニー | 水不溶性ポルフィリンの脂質錯体の凍結乾燥物 |
| US6893868B2 (en) | 1997-02-20 | 2005-05-17 | Onco Immunin, Inc. | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples |
| US5986030A (en) | 1997-04-15 | 1999-11-16 | Nalco Chemical Company | Fluorescent water soluble polymers |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| JP3078793B2 (ja) | 1998-04-30 | 2000-08-21 | 株式会社分子バイオホトニクス研究所 | ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法 |
| US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6514700B1 (en) | 1999-04-30 | 2003-02-04 | Aclara Biosciences, Inc. | Nucleic acid detection using degradation of a tagged sequence |
| US6627400B1 (en) | 1999-04-30 | 2003-09-30 | Aclara Biosciences, Inc. | Multiplexed measurement of membrane protein populations |
| US20020142329A1 (en) | 1999-04-30 | 2002-10-03 | Aclara Biosciences, Inc. | Compositions and methods employing cleavable electrophoretic tag reagents |
| US7037654B2 (en) | 1999-04-30 | 2006-05-02 | Aclara Biosciences, Inc. | Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents |
| AU5935300A (en) | 1999-07-22 | 2001-02-13 | Nalco Chemical Company | Fluorescent water-soluble polymers |
| US6479650B1 (en) | 1999-12-14 | 2002-11-12 | Research Corporation Technologies, Inc. | Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same |
| AU2001245643A1 (en) | 2000-03-14 | 2001-09-24 | Genigma Corporation | Biomarkers for the labeling, visual detection and quantification of biomolecules |
| JP2004515208A (ja) | 2000-03-28 | 2004-05-27 | ナノスフェアー インコーポレイテッド | オリゴヌクレオチドを付着させたナノ粒子とその使用方法 |
| US20040067498A1 (en) | 2000-04-28 | 2004-04-08 | Ahmed Chenna | Detection of nucleic acid sequences by cleavage and separation of tag-containing structures |
| US6743640B2 (en) | 2000-05-08 | 2004-06-01 | Qtl Biosystems Llc | Fluorescent polymer-QTL approach to biosensing |
| AU2001265252A1 (en) | 2000-05-31 | 2001-12-11 | The Johns-Hopkins University | Biologically useful polyphosphates |
| US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
| JP2004508838A (ja) | 2000-09-11 | 2004-03-25 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 組合せ蛍光エネルギー移動タグ及びそれらの使用 |
| EP1319047B1 (en) | 2000-09-19 | 2006-01-04 | Li-Cor, Inc. | Cyanine dyes |
| US6448407B1 (en) | 2000-11-01 | 2002-09-10 | Pe Corporation (Ny) | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| GB2372256A (en) | 2001-02-14 | 2002-08-21 | Kalibrant Ltd | Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection |
| US6743905B2 (en) | 2001-04-16 | 2004-06-01 | Applera Corporation | Mobility-modified nucleobase polymers and methods of using same |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| JP3813890B2 (ja) | 2002-03-22 | 2006-08-23 | 富士写真フイルム株式会社 | 3層レジストプロセス用中間層材料組成物及びそれを用いたパターン形成方法 |
| US7270956B2 (en) | 2002-08-26 | 2007-09-18 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| US20040086914A1 (en) | 2002-07-12 | 2004-05-06 | Affymetrix, Inc. | Nucleic acid labeling methods |
| AU2003262833A1 (en) | 2002-08-23 | 2004-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent glycosides and methods for their use |
| US20040138467A1 (en) | 2002-11-26 | 2004-07-15 | French Roger Harquail | Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties |
| US7759459B2 (en) | 2003-01-10 | 2010-07-20 | Albert Einstein College Of Medicine Of Yeshiva University | Fluorescent assays for protein kinases |
| US7238792B2 (en) | 2003-03-18 | 2007-07-03 | Washington State University Research Foundation | Foldable polymers as probes |
| US7172907B2 (en) | 2003-03-21 | 2007-02-06 | Ge Healthcare Bio-Sciences Corp. | Cyanine dye labelling reagents with meso-substitution |
| ES2330115T3 (es) | 2003-08-14 | 2009-12-04 | Cellectis | Composicion antibacteriana, mas particilarmente contra las bacterias gram-negativas, que comprende un peptido y un agente antibacteriano ventajosamente hidrofobo. |
| EP1689764B1 (en) | 2003-11-19 | 2013-01-02 | AlleLogic Biosciences Corporation | Oligonucleotides labeled with a plurality of fluorophores |
| US20050123935A1 (en) | 2003-12-09 | 2005-06-09 | Richard Haugland | Pyrenyloxysulfonic acid fluorescent agents |
| AU2005325262B2 (en) | 2004-04-27 | 2011-08-11 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety |
| US8652851B2 (en) | 2004-06-17 | 2014-02-18 | University Of Florida Research Foundation, Inc. | Multi-acceptor molecular probes and applications thereof |
| US20060035302A1 (en) | 2004-06-21 | 2006-02-16 | Applera Corporation | Kinase substrates with multiple phosphorylation sites |
| EP1789794A1 (en) | 2004-09-14 | 2007-05-30 | Applera Corporation, Applied Biosystems Group | Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes |
| US8153706B2 (en) | 2004-10-25 | 2012-04-10 | Hewlett-Packard Development Company, L.P. | Polymeric colorants having pigment and dye components and corresponding ink compositions |
| ATE364643T1 (de) | 2004-11-09 | 2007-07-15 | Ipagsa Ind Sl | Thermisch reaktive, nah-infrarot absorbierende polymere und ihre verwendung in wärmeempfindlichen lithographischen druckplatten |
| EP2502946B1 (en) | 2005-01-10 | 2017-10-04 | The Regents of The University of California | Cationic conjugated polymers suitable for strand-specific polynucleiotide detection in homogeneous and solid state assays |
| CA2599709A1 (en) | 2005-03-09 | 2006-09-21 | Cepheid | Polar dyes |
| US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| EP1928822B1 (en) | 2005-09-26 | 2013-02-27 | Life Technologies Corporation | Violet laser excitable dyes and their method of use |
| US7888043B2 (en) | 2005-11-18 | 2011-02-15 | The United States Of America As Represented By The Department Of Health And Human Services, Centers For Disease Control And Prevention | Modified cardiolipin and uses therefor |
| EP1961052B1 (en) | 2005-12-12 | 2013-03-06 | Basf Se | Organic semiconductors and their manufacture |
| US20070148094A1 (en) | 2005-12-22 | 2007-06-28 | Uzgiris Egidijus E | Polymeric imaging agents and medical imaging methods |
| JP5493117B2 (ja) | 2006-02-15 | 2014-05-14 | 国立大学法人岐阜大学 | オリゴヌクレオチド誘導体及びその利用 |
| DK2029120T3 (da) | 2006-04-13 | 2011-10-31 | Midatech Ltd | Nanopartikler indeholdende tre forskellige ligander til tilvejebringelse af immunresponser mod smitstoffer |
| WO2008021208A2 (en) | 2006-08-12 | 2008-02-21 | Stx Aprilis, Inc. | Sensitizer dyes for photoacid generating systems using short visible wavelengths |
| CN101523631B (zh) | 2006-10-12 | 2010-09-22 | 出光兴产株式会社 | 有机薄膜晶体管元件以及有机薄膜发光晶体管 |
| WO2008076524A2 (en) | 2006-10-27 | 2008-06-26 | Life Technologies Corporation | Fluorogenic ph sensitive dyes and their method of use |
| US8053588B2 (en) | 2007-03-07 | 2011-11-08 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Organosilane compound and organosilica obtained therefrom |
| PT2144633E (pt) | 2007-04-23 | 2014-10-27 | Deliversir Ltd | Um sistema para a administração de agentes terapêuticos em células vivas e núcleos de células |
| US9556210B2 (en) | 2007-04-23 | 2017-01-31 | Sabag-Rfa Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
| US9156865B2 (en) | 2007-04-23 | 2015-10-13 | Deliversir Ltd | System for delivering therapeutic agents into living cells and cells nuclei |
| JP5518697B2 (ja) | 2007-05-11 | 2014-06-11 | ビーエーエスエフ ソシエタス・ヨーロピア | 高分子色素 |
| EP2014698A1 (en) | 2007-07-12 | 2009-01-14 | Crystax Pharmaceuticals S.L. | Polymers and their use as fluorescent labels |
| TWI409280B (zh) | 2007-07-31 | 2013-09-21 | American Dye Source Inc | 聚合物染料、塗覆層組合物及熱微影印刷板 |
| GB2456298A (en) | 2008-01-07 | 2009-07-15 | Anthony Ian Newman | Electroluminescent materials comprising oxidation resistant fluorenes |
| JP5467366B2 (ja) | 2008-03-10 | 2014-04-09 | 国立大学法人 東京大学 | 非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されたカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用 |
| CA2721980C (en) | 2008-04-21 | 2017-01-03 | The Regents Of The University Of California | Selective high-affinity poly dentate ligands and methods of making such |
| US20100021901A1 (en) | 2008-05-22 | 2010-01-28 | Peng Yin | Compositions and methods for detecting analytes |
| KR101041446B1 (ko) | 2008-07-21 | 2011-06-14 | 부산대학교 산학협력단 | 공액고분자 2단계 fret 시스템 및 바이오센서 |
| WO2010026957A1 (ja) | 2008-09-03 | 2010-03-11 | 国立大学法人 富山大学 | 水溶性ロタキサン型蛍光色素および蛍光性有機分子 |
| EP2366027B1 (en) | 2008-11-20 | 2017-01-11 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Rapid fret-based diagnosis of bacterial pathogens |
| CN102317332B (zh) | 2008-12-12 | 2014-04-30 | 马萨诸塞大学 | 两性离子聚合物 |
| BR112012001043A2 (pt) | 2009-07-16 | 2016-03-15 | Beckman Coulter Inc | tinturas fluorescentes e uso das mesmas |
| CN102791827B (zh) | 2009-11-09 | 2016-11-16 | 华盛顿大学商业化中心 | 官能化发色聚合物点及其生物共轭体 |
| US9400273B1 (en) | 2009-12-09 | 2016-07-26 | Life Technologies Corporation | 7-hydroxycoumarin-based cell-tracking reagents |
| JP2011135823A (ja) | 2009-12-28 | 2011-07-14 | Nagoya Univ | オリゴヌクレオチドプローブ及びその利用 |
| US9221759B2 (en) | 2010-01-13 | 2015-12-29 | Rutgers, The State University Of New Jersey | Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency |
| WO2011113020A1 (en) | 2010-03-11 | 2011-09-15 | Glumetrics, Inc. | Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| EP2577309B1 (en) | 2010-05-25 | 2016-11-23 | Carnegie Mellon University | Targeted probes of cellular physiology |
| WO2012005310A1 (ja) | 2010-07-08 | 2012-01-12 | 旭硝子株式会社 | 含フッ素芳香族化合物、有機半導体材料および有機薄膜デバイス |
| EP3345944B1 (en) | 2010-09-22 | 2020-03-18 | The Board of Regents of the University of Texas System | Novel block copolymer and micelle compositions and methods of use thereof |
| CA2821411C (en) | 2010-12-13 | 2020-02-25 | Quiapeg Pharmaceuticals Ab | Functionalized polymers |
| WO2012086857A1 (ko) | 2010-12-21 | 2012-06-28 | (주)파낙스이엠 | 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 |
| CN102174078A (zh) | 2011-01-10 | 2011-09-07 | 中国药科大学 | 肿瘤细胞选择性穿膜肽的应用 |
| EP2769226B1 (en) | 2011-07-15 | 2017-05-24 | Medtronic Minimed, Inc. | Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors |
| CA2845845A1 (en) | 2011-08-31 | 2013-03-07 | Mallinckrodt Llc | Nanoparticle peg modification with h-phosphonates |
| US20130059343A1 (en) | 2011-09-06 | 2013-03-07 | Li-Cor, Inc. | Nucleotide derivatives |
| US9085761B1 (en) * | 2012-06-14 | 2015-07-21 | Affymetrix, Inc. | Methods and compositions for amplification of nucleic acids |
| US9932578B2 (en) | 2012-09-12 | 2018-04-03 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to P53 and methods of use thereof |
| US20150258217A1 (en) | 2012-10-04 | 2015-09-17 | The General Hospital Corporation | Methods of Synthesizing and Using Peg-Like Fluorochromes |
| CN104918639B (zh) | 2012-10-22 | 2018-01-26 | 萨拜格Rfa公司 | 用于将治疗剂递送到活细胞和细胞核中的系统 |
| WO2014102803A1 (en) | 2012-12-31 | 2014-07-03 | Yeda Research And Development Co. Ltd. | Molecular sensor and methods of use thereof |
| US9545447B2 (en) | 2013-01-04 | 2017-01-17 | The Texas A&M University System | Polymer-drug systems |
| US9169256B2 (en) | 2013-03-13 | 2015-10-27 | Elitechgroup B.V. | Artificial nucleic acids |
| US9714946B2 (en) | 2013-03-14 | 2017-07-25 | Dana-Farber Cancer Institute, Inc. | Bromodomain binding reagents and uses thereof |
| JP6606487B2 (ja) | 2013-03-15 | 2019-11-13 | ビセン メディカル, インコーポレイテッド | invitroおよびinvivoイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素 |
| WO2014147642A1 (en) | 2013-03-19 | 2014-09-25 | Council Of Scientific & Industrial Research | Substituted fluoranthene-7-carbonitriles as fluorescent dyes for cell imaging applications |
| CN103319378B (zh) | 2013-06-27 | 2015-06-10 | 中国科学院宁波材料技术与工程研究所 | 两性离子有机小分子太阳能电池阴极界面材料及其制法和用途 |
| KR101572901B1 (ko) | 2013-07-12 | 2015-12-15 | 부산대학교 산학협력단 | 2-단계 fret를 이용한 공액고분자 전해질 및 압타머 프로브 기반 표적 물질의 검출 방법 및 형광 센서 |
| US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| WO2015068697A1 (ja) | 2013-11-11 | 2015-05-14 | オリンパスメディカルシステムズ株式会社 | 処置システム |
| CN105829427A (zh) | 2013-12-06 | 2016-08-03 | 蒙诺苏尔有限公司 | 用于水溶性膜的荧光示踪剂、相关方法和相关物品 |
| CA2929972C (en) | 2013-12-20 | 2018-07-24 | F. Hoffmann-La Roche Ag | Use of compounds comprising two or more hydrophobic domains and a hydrophilic domain comprising peg moieties for stabilization of a cell |
| US9689877B2 (en) | 2014-01-16 | 2017-06-27 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| JP6374172B2 (ja) | 2014-01-31 | 2018-08-15 | 富士フイルム株式会社 | 着色組成物、およびこれを用いた硬化膜、カラーフィルタ、パターン形成方法、カラーフィルタの製造方法、固体撮像素子、画像表示装置ならびに染料多量体 |
| CN104072727A (zh) | 2014-06-23 | 2014-10-01 | 华南理工大学 | 一种含磷脂酰胆碱基的2,7-芴的共轭聚合物及其制备方法与应用 |
| MX2017004580A (es) | 2014-10-10 | 2017-06-27 | Pfizer | Combinaciones de auristatina sinergica. |
| WO2016077625A1 (en) | 2014-11-12 | 2016-05-19 | Stayton Patrick S | Stabilized polymeric carriers for therapeutic agent delivery |
| EP3218414A1 (en) | 2014-11-14 | 2017-09-20 | Angiochem Inc. | Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin |
| JP6982500B2 (ja) | 2015-02-26 | 2021-12-17 | ソニーグループ株式会社 | フェニルエチニルナフタレン染料およびそれらの使用方法 |
| JP6806694B2 (ja) | 2015-02-26 | 2021-01-06 | ソニー株式会社 | 共役基を含む水溶性蛍光染料または有色染料 |
| US9758625B2 (en) | 2015-03-12 | 2017-09-12 | Becton, Dickinson And Company | Polymeric BODIPY dyes and methods for using the same |
| CN107922454B (zh) | 2015-04-15 | 2021-10-22 | 生物检索技术股份有限公司 | 双猝灭剂探针 |
| US10865310B2 (en) | 2015-05-11 | 2020-12-15 | Sony Corporation Of America | Ultra bright dimeric or polymeric dyes |
| US9670318B2 (en) | 2015-05-28 | 2017-06-06 | Miltenyi Biotec Gmbh | Bright fluorochromes based on multimerization of fluorescent dyes |
| JP6997455B2 (ja) | 2015-06-02 | 2022-01-17 | ユニバーシティ・オブ・ワシントン | 自立非汚染性ポリマー、それらの組成物、および関連モノマー |
| JP6817288B2 (ja) | 2015-08-10 | 2021-01-20 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 新規な連結体及び生体分子と薬物との特異的共役におけるその使用 |
| WO2017062271A2 (en) | 2015-10-06 | 2017-04-13 | Merck Sharp & Dohme Corp. | Antibody drug conjugate for anti-inflammatory applications |
| HRP20240795T1 (hr) | 2015-11-25 | 2024-09-13 | Ligachem Biosciences Inc. | Konjugati koji se sastoje od samozapaljujućih skupina i postupci povezani s njima |
| WO2017094897A1 (ja) | 2015-12-04 | 2017-06-08 | 全薬工業株式会社 | 血中滞留性を改善した抗il-17アプタマー |
| US9913992B2 (en) | 2015-12-22 | 2018-03-13 | Colgate-Palmolive Company | Oral treatment device |
| JP2017124994A (ja) | 2016-01-15 | 2017-07-20 | 靖彦 中村 | 癌治療及び癌再発防止のための装置並びにポルフィリン類含有製剤 |
| US11434377B2 (en) | 2016-04-01 | 2022-09-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| AU2017240154B2 (en) | 2016-04-01 | 2021-08-12 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US9851359B2 (en) | 2016-04-06 | 2017-12-26 | Sony Corporation Of America | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| US11370922B2 (en) | 2016-05-10 | 2022-06-28 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| WO2017197014A2 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| KR102526802B1 (ko) | 2016-05-11 | 2023-05-02 | 소니그룹주식회사 | 초고명도 이량체성 또는 중합체성 염료 |
| WO2017214165A1 (en) | 2016-06-06 | 2017-12-14 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
| JP7312929B2 (ja) | 2016-07-29 | 2023-07-24 | ソニーグループ株式会社 | 超明色二量体またはポリマー色素およびその調製のための方法 |
| EP3507603B1 (en) | 2016-09-01 | 2024-03-06 | Life Technologies Corporation | Compositions and methods for enhanced fluorescence |
| GB2554666B (en) | 2016-09-30 | 2019-12-18 | Sumitomo Chemical Co | Composite Particle |
| CN106589005B (zh) | 2016-11-01 | 2019-08-06 | 北京擎科生物科技有限公司 | 一种荧光信号放大探针中间体、荧光探针及其制备方法 |
| CA3054609A1 (en) | 2017-02-27 | 2018-08-30 | Ivanti, Inc. | Systems and methods for role-based computer security configurations |
| US12398104B2 (en) | 2017-04-27 | 2025-08-26 | The Procter & Gamble Company | Odorless thiols for permanent waving, straightening and depilatory applications |
| WO2019010414A1 (en) | 2017-07-07 | 2019-01-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Fatty acid derivatives and their use |
| CN111093711A (zh) | 2017-10-05 | 2020-05-01 | 索尼公司 | 可编程的树枝状药物 |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| WO2019118714A1 (en) | 2017-12-13 | 2019-06-20 | Sony Corporation | Ionic polymers comprising biologically active compounds |
| EP3727463A1 (en) | 2017-12-21 | 2020-10-28 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| CN111565756A (zh) | 2018-01-12 | 2020-08-21 | 索尼公司 | 包含生物活性化合物的具有刚性间隔基团的聚合物 |
| EP3737419B1 (en) | 2018-01-12 | 2024-04-10 | Sony Group Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| US12194104B2 (en) | 2018-01-12 | 2025-01-14 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| KR102864292B1 (ko) | 2018-03-21 | 2025-09-26 | 소니그룹주식회사 | 링커 군을 갖는 중합체성 텐덤 염료 |
| GB201807815D0 (en) | 2018-05-14 | 2018-06-27 | Hypha Discovery Ltd | Hydroxylation techniques |
| US10755781B2 (en) | 2018-06-06 | 2020-08-25 | Micron Technology, Inc. | Techniques for programming multi-level self-selecting memory cell |
| US12006438B2 (en) | 2018-06-27 | 2024-06-11 | Sony Group Corporation | Polymeric dyes with linker groups comprising deoxyribose |
| EP3820944A1 (en) | 2018-07-13 | 2021-05-19 | Sony Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| KR102606247B1 (ko) | 2018-07-30 | 2023-11-27 | 삼성전자주식회사 | 도전성 핀의 적어도 일부를 지지하기 위한 지지 부분을 포함하는 커넥터 및 이를 포함하는 전자 장치 |
| US20220160887A1 (en) | 2019-04-11 | 2022-05-26 | Sony Group Corporation | Programmable polymeric drugs |
| WO2020210692A1 (en) | 2019-04-11 | 2020-10-15 | Sony Corporation | Programmable polymeric drugs |
| EP3952918A1 (en) | 2019-04-11 | 2022-02-16 | Sony Group Corporation | Programmable polymeric drugs |
| WO2020219959A1 (en) | 2019-04-24 | 2020-10-29 | Magenta Therapeutics, Inc. | Anti-cd45 antibody drug conjugates and uses thereof |
| WO2021062176A2 (en) | 2019-09-26 | 2021-04-01 | Sony Corporation | Polymeric tandem dyes with linker groups |
| EP4038081A1 (en) | 2019-09-30 | 2022-08-10 | Sony Group Corporation | Nucleotide probes |
| EP4251764A1 (en) | 2020-11-25 | 2023-10-04 | Sony Group Corporation | Polymer dyes |
| WO2022125564A1 (en) | 2020-12-07 | 2022-06-16 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| KR20240021812A (ko) | 2021-06-16 | 2024-02-19 | 소니그룹주식회사 | 분석물 분자의 시각적 검출을 위한 형광단 및 발색단-함유 접합물의 제조 방법 |
| KR20240038965A (ko) | 2021-07-22 | 2024-03-26 | 소니그룹주식회사 | 중합체성 약물의 자동화된 합성 |
| EP4408477A1 (en) | 2021-09-30 | 2024-08-07 | Sony Group Corporation | Pyrrolobenzodiazepine conjugates for cancer treatment |
| US20250009786A1 (en) | 2021-09-30 | 2025-01-09 | Sony Group Corporation | Automated synthesis of polymeric dual drugs |
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2017
- 2017-03-31 AU AU2017240154A patent/AU2017240154B2/en active Active
- 2017-03-31 RU RU2018137690A patent/RU2762328C2/ru active
- 2017-03-31 KR KR1020237014901A patent/KR102773661B1/ko active Active
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- 2017-03-31 KR KR1020177019774A patent/KR102530707B1/ko active Active
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- 2017-03-31 WO PCT/US2017/025530 patent/WO2017173355A1/en not_active Ceased
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2021
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006020947A2 (en) * | 2004-08-13 | 2006-02-23 | Epoch Biosciences, Inc. | Phosphonate fluorescent dyes and conjugates |
| EP2366785A1 (en) * | 2008-11-14 | 2011-09-21 | Japan Science And Technology Agency | Oligonucleotide derivative, labeling agent, and use of the labeling agent |
| CN105377994A (zh) * | 2013-08-22 | 2016-03-02 | 索尼公司 | 水溶性荧光染料或有色染料及其使用方法 |
Non-Patent Citations (1)
| Title |
|---|
| 王国建: "高分子现代合成方法与技术", vol. 1, 同济大学出版社, pages: 210 - 211 * |
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| Publication number | Publication date |
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| BR112018070164A2 (pt) | 2019-01-29 |
| CN107580618A (zh) | 2018-01-12 |
| US11981820B2 (en) | 2024-05-14 |
| KR20180132501A (ko) | 2018-12-12 |
| KR102773661B1 (ko) | 2025-02-27 |
| RU2018137690A3 (https=) | 2020-07-08 |
| US20210395530A1 (en) | 2021-12-23 |
| US12577403B2 (en) | 2026-03-17 |
| WO2017173355A1 (en) | 2017-10-05 |
| CA3018564A1 (en) | 2017-10-05 |
| US11142647B2 (en) | 2021-10-12 |
| JP7049113B2 (ja) | 2022-04-06 |
| KR20250029292A (ko) | 2025-03-04 |
| CA3018564C (en) | 2024-04-23 |
| EP3436529A1 (en) | 2019-02-06 |
| RU2762328C2 (ru) | 2021-12-17 |
| CA3231845A1 (en) | 2017-10-05 |
| KR20230066652A (ko) | 2023-05-16 |
| US20190016898A1 (en) | 2019-01-17 |
| RU2018137690A (ru) | 2020-05-12 |
| JP2019516807A (ja) | 2019-06-20 |
| BR112018070164B1 (pt) | 2022-09-27 |
| AU2017240154A1 (en) | 2018-10-11 |
| AU2017240154B2 (en) | 2021-08-12 |
| KR102530707B1 (ko) | 2023-05-11 |
| US20240287314A1 (en) | 2024-08-29 |
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