CN114805342A - 氟化四氢萘啶基壬酸衍生物及其用途 - Google Patents

氟化四氢萘啶基壬酸衍生物及其用途 Download PDF

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Publication number
CN114805342A
CN114805342A CN202210129062.7A CN202210129062A CN114805342A CN 114805342 A CN114805342 A CN 114805342A CN 202210129062 A CN202210129062 A CN 202210129062A CN 114805342 A CN114805342 A CN 114805342A
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fold
compounds
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Chinese (zh)
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B.C.阿斯库
古谷建
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Scifluor Life Sciences Inc
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Scifluor Life Sciences Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202210129062.7A 2015-02-19 2016-02-19 氟化四氢萘啶基壬酸衍生物及其用途 Pending CN114805342A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562118303P 2015-02-19 2015-02-19
US62/118303 2015-02-19
CN201680022826.5A CN107531699A (zh) 2015-02-19 2016-02-19 氟化四氢萘啶基壬酸衍生物及其用途
PCT/US2016/018612 WO2016134223A2 (en) 2015-02-19 2016-02-19 Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof

Related Parent Applications (1)

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CN201680022826.5A Division CN107531699A (zh) 2015-02-19 2016-02-19 氟化四氢萘啶基壬酸衍生物及其用途

Publications (1)

Publication Number Publication Date
CN114805342A true CN114805342A (zh) 2022-07-29

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CN202210129062.7A Pending CN114805342A (zh) 2015-02-19 2016-02-19 氟化四氢萘啶基壬酸衍生物及其用途
CN201680022826.5A Pending CN107531699A (zh) 2015-02-19 2016-02-19 氟化四氢萘啶基壬酸衍生物及其用途

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Country Link
US (5) US9790222B2 (https=)
EP (2) EP3925959A1 (https=)
JP (2) JP2018510139A (https=)
KR (1) KR102647026B1 (https=)
CN (2) CN114805342A (https=)
AU (1) AU2016219906B2 (https=)
BR (1) BR112017017888A2 (https=)
CA (1) CA2976634C (https=)
ES (1) ES2892954T3 (https=)
IL (1) IL253873A0 (https=)
RU (1) RU2017132433A (https=)
TW (1) TWI736529B (https=)
WO (1) WO2016134223A2 (https=)

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PT2953948T (pt) 2013-02-07 2017-12-12 Scifluor Life Sciences Inc Antagonistas de integrina fluorada
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GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
US9790222B2 (en) * 2015-02-19 2017-10-17 Scifluor Life Sciences, Inc. Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
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KR102700471B1 (ko) 2017-11-07 2024-08-28 브리스톨-마이어스 스큅 컴퍼니 알파 v 인테그린 억제제로서의 피롤로피라진 유도체
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WO2020047208A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
CN115989235A (zh) * 2020-05-07 2023-04-18 普利安特治疗公司 使用氨基酸化合物治疗呼吸系统疾病的方法
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Publication number Publication date
ES2892954T3 (es) 2022-02-07
AU2016219906A1 (en) 2017-09-07
WO2016134223A3 (en) 2016-10-20
WO2016134223A2 (en) 2016-08-25
IL253873A0 (en) 2017-10-31
JP2018510139A (ja) 2018-04-12
RU2017132433A3 (https=) 2019-03-25
JP7191299B2 (ja) 2022-12-19
KR20170117578A (ko) 2017-10-23
EP3259271A2 (en) 2017-12-27
US20240092775A1 (en) 2024-03-21
US20210277000A1 (en) 2021-09-09
JP2021008511A (ja) 2021-01-28
CA2976634C (en) 2023-10-17
US20160244447A1 (en) 2016-08-25
KR102647026B1 (ko) 2024-03-12
US12286432B2 (en) 2025-04-29
TW201643161A (zh) 2016-12-16
US11685738B2 (en) 2023-06-27
AU2016219906B2 (en) 2020-10-01
EP3925959A1 (en) 2021-12-22
US9790222B2 (en) 2017-10-17
CA2976634A1 (en) 2016-08-25
RU2017132433A (ru) 2019-03-19
US20170369490A1 (en) 2017-12-28
US10301307B2 (en) 2019-05-28
CN107531699A (zh) 2018-01-02
BR112017017888A2 (pt) 2018-04-10
EP3259271B1 (en) 2021-05-05
US20190225609A1 (en) 2019-07-25
EP3259271A4 (en) 2018-07-11
TWI736529B (zh) 2021-08-21

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Application publication date: 20220729