CN114796361A - 一种治疗宫颈癌的中药膏剂及其制备方法 - Google Patents
一种治疗宫颈癌的中药膏剂及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种治疗宫颈癌的中药膏剂及其制备方法，所述的治疗宫颈癌的中药膏剂，由以下原料制成：白英、补血草、茯苓、桂心、生地、白花蛇舌草、王不留行、穿破石、黄荆、马钱子、丹皮、广木香和炒钩藤；本发明的中药膏剂具有清热解毒、祛湿利尿、活血通经、软坚散结的功效，同时具有滋补肝肾、调节机体免疫力的效果；采用标本兼治的原则达到对宫颈癌良好的治疗效果。
Description
技术领域
本发明属于中药药物领域，具体涉及一种治疗宫颈癌的中药膏剂及其制备方法。
背景技术
宫颈癌是指发生在子宫阴道部及宫颈管的妇科恶性肿瘤，严重威胁着女性的健康，近年来，该病发病率具有年轻化的趋势，目前治疗宫颈癌的方法主要包括手术治疗以及放疗和化疗，手术治疗可以达到切除肿瘤的目的，但是手术治疗一方面风险高，对患者身体造成的伤害较大，造成患者免疫力降低；另一方面其花费高，对患者造成巨大经济压力，且仅适用于早期宫颈癌患者；放疗和化疗的方法在杀死肿瘤细胞的同时，也会杀死白细胞、淋巴细胞等人体自身免疫细胞而破坏人体自身免疫系统，造成患者的免疫力降低，而诱发并发症，且治疗周期长，给患者的身体和生活质量带来巨大影响。
发明内容
针对现有技术的不足，本发明的目的是提供一种治疗宫颈癌的中药膏剂及其制备方法，本发明的中药膏剂具有清热解毒、祛湿利尿、活血通经、软坚散结的功效，同时具有滋补肝肾、调节机体免疫力的效果；采用标本兼治的原则达到对宫颈癌良好的治疗效果。
为达到上述目的，本发明采用的技术方案如下：
一种治疗宫颈癌的中药膏剂，由以下原料制成：白英、补血草、茯苓、桂心、生地、白花蛇舌草、王不留行、穿破石、黄荆、马钱子、丹皮、广木香和炒钩藤。
优选地，所述的中药膏剂由以下重量份数的原料制成：白英20-30份、补血草20-30份、茯苓20-30份、桂心15-25份、生地20-25份、白花蛇舌草15-25份、王不留行20-25份、穿破石15-20份、黄荆15-20份、马钱子10-15份、丹皮15-20份、广木香15-20份和炒钩藤10-15份。
优选地，所述的中药膏剂由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地22.5份、白花蛇舌草20份、王不留行22.5份、穿破石17.5份、黄荆17.5份、马钱子12.5份、丹皮17.5份、广木香17.5份和炒钩藤12.5份。
进一步地，所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加调和剂制作成膏剂即得；
优选地，所述的调和剂为蜂蜜或麦芽糖。
中医认为，宫颈癌多由肝郁气于冲任失调，肝经湿热，脾虚湿浊，瘀毒下注，湿毒未净，脾肾双亏而致；因此，本发明采用标本兼治，一方面疏肝理气，滋补肝肾；另一方面清热利湿，化瘀解毒，软坚散结为治疗原则构成治疗宫颈癌的中药组方。
本发明的治疗宫颈癌的组方中，白英清热解毒，利湿消肿，抗癌，补血草止血散瘀；茯苓利水渗湿，健脾宁心；三者共为君药，桂心消淤通络；镇心安神；生地清热凉血、益阴生津；白花蛇舌草清热解毒，利湿通淋；王不留行活血通经，下乳消肿，利尿通淋；穿破石祛风利湿，活血通经；黄荆清热解毒，利湿；马钱子散结消肿，通络止痛；共为臣药，协助君药；丹皮清热凉血、活血化瘀；广木香温中行气，健脾；炒钩藤清热平肝，熄风止痉，共为佐药；全方合用达到清热解毒、祛湿利尿、活血通经、软坚散结的功效，同时具有滋补肝肾、调节机体免疫力的效果；达到对病症局部和全身相结合的治疗效果。
本发明的中药原料来源广泛，成本低，治疗宫颈癌安全性高，无任何副作用，可解决现有技术中的放射治疗和化学治疗乳腺癌而其给患者身体带来的副作用和造成的巨大经济压力的问题。
具体实施例方式
下面结合具体实施例对本发明的技术方案进行详细说明，以使本领域技术人员可以更好的理解本发明并能予以实施，但所列举的具体实施例不能作为对本发明的限定。
实施例1
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英20份、补血草20份、茯苓20份、桂心15份、生地20份、白花蛇舌草15份、王不留行20份、穿破石15份、黄荆15份、马钱子10份、丹皮15份、广木香15份和炒钩藤10份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
实施例2
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地22份、白花蛇舌草20份、王不留行22份、穿破石17份、黄荆17份、马钱子12份、丹皮17份、广木香17份和炒钩藤12份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
实施例3
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地22.5份、白花蛇舌草20份、王不留行22.5份、穿破石17.5份、黄荆17.5份、马钱子12.5份、丹皮17.5份、广木香17.5份和炒钩藤12.5份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
实施例4
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地23份、白花蛇舌草20份、王不留行23份、穿破石18份、黄荆18份、马钱子13份、丹皮18份、广木香18份和炒钩藤13份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
实施例5
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英30份、补血草30份、茯苓30份、桂心25份、生地25份、白花蛇舌草25份、王不留行25份、穿破石20份、黄荆20份、马钱子15份、丹皮20份、广木香20份和炒钩藤15份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
毒性试验
试验方法：选择生命体征正常的20只小鼠，其中10只雄性，10只雌性；将本发明实施例3制备的中药膏剂分散于生理盐水中，对20只试验组小鼠进行灌胃，每天灌胃一次，对小鼠的生长情况进行观察，灌胃10天后，20只小鼠的生长状况良好，小鼠的活动、饮食排泄物以及精神状态未发现异常；未出现毒性反应；试验证明本发明的治疗宫颈癌的中药膏剂不具有毒性作用和不良反应，安全性高。
临床应用
典型病例
病例1，刘某，女，55岁，阴道出血，小腹胀痛，尿频尿急，经医院检查确诊为宫颈癌，已错过最佳的治疗时机，且患者自身身体状况不佳，患有高血压、糖尿病等疾病，决定放弃治疗，后经服用本发明中药膏剂6个疗程后，出血减少，症状有所缓解；继续服用4个疗程后，临床症状消失。
病例2，薛某，女，42岁，宫颈不规则出血，阴道分泌物有异味，经医院检查确诊为宫颈癌早期，在医院化疗过程中，出现恶心呕吐、食欲不振，体重下降，放弃化疗，服用本发明中药膏剂4个疗程后，腹痛症状减轻，继续服用本发明中药膏剂2个疗程后，宫颈不再出现出血症状，再继续巩固服用2个疗程后，去医院检查，肿瘤消失。
病例3，吴某，女，46岁，宫颈癌二期，在医院进行化疗4个周期，放疗5个周期后，病情不见好转，阴道不规则出血量增多，且患者因放疗化疗出现食欲不振，体重下降；神疲乏力，腹部胀痛；停止放化疗，开始服用本发明的中药膏剂，服用2个疗程后，身体状况有所好转，精气神恢复，饮食正常；继续服用4个疗程后出血量减少，临床症状缓解；再服用1个疗程后，宫颈不再出血，临床症状消失。
用法用量：所述口服本发明中药膏剂一个疗程为30天，用量依据患者病情酌情增减。
以上实施例仅为本发明较佳的具体实施方式，本发明的保护范围不限于此，任何熟悉本技术领域的技术人员在本发明披露的技术范围内，可显而易见地得到的技术方案的简单变化或等效替换均落入本发明的保护范围内。
Claims (5)
1.一种治疗宫颈癌的中药膏剂，其特征在于，由以下原料制成：白英、补血草、茯苓、桂心、生地、白花蛇舌草、王不留行、穿破石、黄荆、马钱子、丹皮、广木香和炒钩藤。
2.如权利要求1所述的治疗宫颈癌的中药膏剂，其特征在于，由以下重量份数的原料制成：白英20-30份、补血草20-30份、茯苓20-30份、桂心15-25份、生地20-25份、白花蛇舌草15-25份、王不留行20-25份、穿破石15-20份、黄荆15-20份、马钱子10-15份、丹皮15-20份、广木香15-20份和炒钩藤10-15份。
3.如权利要求1所述的治疗宫颈癌的中药膏剂，其特征在于，由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地22.5份、白花蛇舌草20份、王不留行22.5份、穿破石17.5份、黄荆17.5份、马钱子12.5份、丹皮17.5份、广木香17.5份和炒钩藤12.5份。
4.如权利要求1-3任一项所述的治疗宫颈癌的中药膏剂的制备方法，其特征在于，具体包括以下步骤：取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加调和剂制作成膏剂即得。
5.如权利要求4所述的治疗宫颈癌的中药膏剂的制备方法，其特征在于，所述的调和剂为蜂蜜或麦芽糖。
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Non-Patent Citations (1)
| Title |
|---|
| 王菊光: "中医辨证治疗子宫颈癌42例分析", 《黑龙江中医药》 * |
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