CN114796361A - 一种治疗宫颈癌的中药膏剂及其制备方法 - Google Patents
一种治疗宫颈癌的中药膏剂及其制备方法 Download PDFInfo
- Publication number
- CN114796361A CN114796361A CN202210268385.4A CN202210268385A CN114796361A CN 114796361 A CN114796361 A CN 114796361A CN 202210268385 A CN202210268385 A CN 202210268385A CN 114796361 A CN114796361 A CN 114796361A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- cervical cancer
- raw materials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 61
- 206010008342 Cervix carcinoma Diseases 0.000 title claims abstract description 35
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 title claims abstract description 35
- 201000010881 cervical cancer Diseases 0.000 title claims abstract description 35
- 239000002674 ointment Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 34
- 210000000582 semen Anatomy 0.000 claims abstract description 7
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 3
- 241001643642 Viticis Species 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000000706 filtrate Substances 0.000 claims description 21
- 238000001914 filtration Methods 0.000 claims description 21
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 10
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 10
- 240000001659 Oldenlandia diffusa Species 0.000 claims description 10
- 244000248825 Peltandra virginica Species 0.000 claims description 10
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 10
- 235000008599 Poria cocos Nutrition 0.000 claims description 10
- 244000178320 Vaccaria pyramidata Species 0.000 claims description 10
- 235000010587 Vaccaria pyramidata Nutrition 0.000 claims description 10
- 244000248021 Vitex negundo Species 0.000 claims description 10
- 235000013427 Vitex negundo var incisa Nutrition 0.000 claims description 10
- 235000014961 Vitex negundo var negundo Nutrition 0.000 claims description 10
- 235000014956 negundo chastetree Nutrition 0.000 claims description 10
- 241000208365 Celastraceae Species 0.000 claims description 9
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 claims description 9
- 244000272264 Saussurea lappa Species 0.000 claims description 9
- 235000006784 Saussurea lappa Nutrition 0.000 claims description 9
- 235000000336 Solanum dulcamara Nutrition 0.000 claims description 9
- 244000107975 Strychnos nux-vomica Species 0.000 claims description 9
- 241000157352 Uncaria Species 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 7
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 7
- 241001149105 Limonium sinense Species 0.000 claims description 5
- 240000003664 Maclura cochinchinensis Species 0.000 claims description 5
- 241000201282 Limonium Species 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 235000012907 honey Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 22
- 238000011282 treatment Methods 0.000 abstract description 16
- 230000001737 promoting effect Effects 0.000 abstract description 13
- 210000004369 blood Anatomy 0.000 abstract description 12
- 239000008280 blood Substances 0.000 abstract description 12
- 210000004185 liver Anatomy 0.000 abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 6
- 230000003213 activating effect Effects 0.000 abstract description 5
- 230000036039 immunity Effects 0.000 abstract description 5
- 210000003734 kidney Anatomy 0.000 abstract description 5
- 230000027939 micturition Effects 0.000 abstract description 5
- 230000002175 menstrual effect Effects 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 230000004936 stimulating effect Effects 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 230000001988 toxicity Effects 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 13
- 241000699670 Mus sp. Species 0.000 description 7
- 238000002512 chemotherapy Methods 0.000 description 7
- 208000004880 Polyuria Diseases 0.000 description 6
- 230000035619 diuresis Effects 0.000 description 6
- 235000013399 edible fruits Nutrition 0.000 description 6
- 238000001959 radiotherapy Methods 0.000 description 6
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 241000218211 Maclura Species 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000001914 calming effect Effects 0.000 description 3
- 210000003679 cervix uteri Anatomy 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 241000405414 Rehmannia Species 0.000 description 2
- 206010046788 Uterine haemorrhage Diseases 0.000 description 2
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000001363 autoimmune Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010008346 Cervix carcinoma stage II Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 235000015506 Solanum lyratum Nutrition 0.000 description 1
- 241000585552 Solanum lyratum Species 0.000 description 1
- 241000157373 Uncaria rhynchophylla Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000006996 mental state Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 229940042125 oral ointment Drugs 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供了一种治疗宫颈癌的中药膏剂及其制备方法，所述的治疗宫颈癌的中药膏剂，由以下原料制成：白英、补血草、茯苓、桂心、生地、白花蛇舌草、王不留行、穿破石、黄荆、马钱子、丹皮、广木香和炒钩藤；本发明的中药膏剂具有清热解毒、祛湿利尿、活血通经、软坚散结的功效，同时具有滋补肝肾、调节机体免疫力的效果；采用标本兼治的原则达到对宫颈癌良好的治疗效果。
Description
技术领域
本发明属于中药药物领域，具体涉及一种治疗宫颈癌的中药膏剂及其制备方法。
背景技术
宫颈癌是指发生在子宫阴道部及宫颈管的妇科恶性肿瘤，严重威胁着女性的健康，近年来，该病发病率具有年轻化的趋势，目前治疗宫颈癌的方法主要包括手术治疗以及放疗和化疗，手术治疗可以达到切除肿瘤的目的，但是手术治疗一方面风险高，对患者身体造成的伤害较大，造成患者免疫力降低；另一方面其花费高，对患者造成巨大经济压力，且仅适用于早期宫颈癌患者；放疗和化疗的方法在杀死肿瘤细胞的同时，也会杀死白细胞、淋巴细胞等人体自身免疫细胞而破坏人体自身免疫系统，造成患者的免疫力降低，而诱发并发症，且治疗周期长，给患者的身体和生活质量带来巨大影响。
发明内容
针对现有技术的不足，本发明的目的是提供一种治疗宫颈癌的中药膏剂及其制备方法，本发明的中药膏剂具有清热解毒、祛湿利尿、活血通经、软坚散结的功效，同时具有滋补肝肾、调节机体免疫力的效果；采用标本兼治的原则达到对宫颈癌良好的治疗效果。
为达到上述目的，本发明采用的技术方案如下：
一种治疗宫颈癌的中药膏剂，由以下原料制成：白英、补血草、茯苓、桂心、生地、白花蛇舌草、王不留行、穿破石、黄荆、马钱子、丹皮、广木香和炒钩藤。
优选地，所述的中药膏剂由以下重量份数的原料制成：白英20-30份、补血草20-30份、茯苓20-30份、桂心15-25份、生地20-25份、白花蛇舌草15-25份、王不留行20-25份、穿破石15-20份、黄荆15-20份、马钱子10-15份、丹皮15-20份、广木香15-20份和炒钩藤10-15份。
优选地，所述的中药膏剂由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地22.5份、白花蛇舌草20份、王不留行22.5份、穿破石17.5份、黄荆17.5份、马钱子12.5份、丹皮17.5份、广木香17.5份和炒钩藤12.5份。
进一步地，所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加调和剂制作成膏剂即得；
优选地，所述的调和剂为蜂蜜或麦芽糖。
中医认为，宫颈癌多由肝郁气于冲任失调，肝经湿热，脾虚湿浊，瘀毒下注，湿毒未净，脾肾双亏而致；因此，本发明采用标本兼治，一方面疏肝理气，滋补肝肾；另一方面清热利湿，化瘀解毒，软坚散结为治疗原则构成治疗宫颈癌的中药组方。
本发明的治疗宫颈癌的组方中，白英清热解毒，利湿消肿，抗癌，补血草止血散瘀；茯苓利水渗湿，健脾宁心；三者共为君药，桂心消淤通络；镇心安神；生地清热凉血、益阴生津；白花蛇舌草清热解毒，利湿通淋；王不留行活血通经，下乳消肿，利尿通淋；穿破石祛风利湿，活血通经；黄荆清热解毒，利湿；马钱子散结消肿，通络止痛；共为臣药，协助君药；丹皮清热凉血、活血化瘀；广木香温中行气，健脾；炒钩藤清热平肝，熄风止痉，共为佐药；全方合用达到清热解毒、祛湿利尿、活血通经、软坚散结的功效，同时具有滋补肝肾、调节机体免疫力的效果；达到对病症局部和全身相结合的治疗效果。
本发明的中药原料来源广泛，成本低，治疗宫颈癌安全性高，无任何副作用，可解决现有技术中的放射治疗和化学治疗乳腺癌而其给患者身体带来的副作用和造成的巨大经济压力的问题。
具体实施例方式
下面结合具体实施例对本发明的技术方案进行详细说明，以使本领域技术人员可以更好的理解本发明并能予以实施，但所列举的具体实施例不能作为对本发明的限定。
实施例1
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英20份、补血草20份、茯苓20份、桂心15份、生地20份、白花蛇舌草15份、王不留行20份、穿破石15份、黄荆15份、马钱子10份、丹皮15份、广木香15份和炒钩藤10份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
实施例2
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地22份、白花蛇舌草20份、王不留行22份、穿破石17份、黄荆17份、马钱子12份、丹皮17份、广木香17份和炒钩藤12份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
实施例3
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地22.5份、白花蛇舌草20份、王不留行22.5份、穿破石17.5份、黄荆17.5份、马钱子12.5份、丹皮17.5份、广木香17.5份和炒钩藤12.5份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
实施例4
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地23份、白花蛇舌草20份、王不留行23份、穿破石18份、黄荆18份、马钱子13份、丹皮18份、广木香18份和炒钩藤13份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
实施例5
一种治疗宫颈癌的中药膏剂，由以下重量份数的原料制成：白英30份、补血草30份、茯苓30份、桂心25份、生地25份、白花蛇舌草25份、王不留行25份、穿破石20份、黄荆20份、马钱子15份、丹皮20份、广木香20份和炒钩藤15份。
所述的治疗宫颈癌的中药膏剂的制备方法具体包括以下步骤：
取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加麦芽糖制作成膏剂即得。
毒性试验
试验方法：选择生命体征正常的20只小鼠，其中10只雄性，10只雌性；将本发明实施例3制备的中药膏剂分散于生理盐水中，对20只试验组小鼠进行灌胃，每天灌胃一次，对小鼠的生长情况进行观察，灌胃10天后，20只小鼠的生长状况良好，小鼠的活动、饮食排泄物以及精神状态未发现异常；未出现毒性反应；试验证明本发明的治疗宫颈癌的中药膏剂不具有毒性作用和不良反应，安全性高。
临床应用
典型病例
病例1，刘某，女，55岁，阴道出血，小腹胀痛，尿频尿急，经医院检查确诊为宫颈癌，已错过最佳的治疗时机，且患者自身身体状况不佳，患有高血压、糖尿病等疾病，决定放弃治疗，后经服用本发明中药膏剂6个疗程后，出血减少，症状有所缓解；继续服用4个疗程后，临床症状消失。
病例2，薛某，女，42岁，宫颈不规则出血，阴道分泌物有异味，经医院检查确诊为宫颈癌早期，在医院化疗过程中，出现恶心呕吐、食欲不振，体重下降，放弃化疗，服用本发明中药膏剂4个疗程后，腹痛症状减轻，继续服用本发明中药膏剂2个疗程后，宫颈不再出现出血症状，再继续巩固服用2个疗程后，去医院检查，肿瘤消失。
病例3，吴某，女，46岁，宫颈癌二期，在医院进行化疗4个周期，放疗5个周期后，病情不见好转，阴道不规则出血量增多，且患者因放疗化疗出现食欲不振，体重下降；神疲乏力，腹部胀痛；停止放化疗，开始服用本发明的中药膏剂，服用2个疗程后，身体状况有所好转，精气神恢复，饮食正常；继续服用4个疗程后出血量减少，临床症状缓解；再服用1个疗程后，宫颈不再出血，临床症状消失。
用法用量：所述口服本发明中药膏剂一个疗程为30天，用量依据患者病情酌情增减。
以上实施例仅为本发明较佳的具体实施方式，本发明的保护范围不限于此，任何熟悉本技术领域的技术人员在本发明披露的技术范围内，可显而易见地得到的技术方案的简单变化或等效替换均落入本发明的保护范围内。
Claims (5)
1.一种治疗宫颈癌的中药膏剂，其特征在于，由以下原料制成：白英、补血草、茯苓、桂心、生地、白花蛇舌草、王不留行、穿破石、黄荆、马钱子、丹皮、广木香和炒钩藤。
2.如权利要求1所述的治疗宫颈癌的中药膏剂，其特征在于，由以下重量份数的原料制成：白英20-30份、补血草20-30份、茯苓20-30份、桂心15-25份、生地20-25份、白花蛇舌草15-25份、王不留行20-25份、穿破石15-20份、黄荆15-20份、马钱子10-15份、丹皮15-20份、广木香15-20份和炒钩藤10-15份。
3.如权利要求1所述的治疗宫颈癌的中药膏剂，其特征在于，由以下重量份数的原料制成：白英25份、补血草25份、茯苓25份、桂心20份、生地22.5份、白花蛇舌草20份、王不留行22.5份、穿破石17.5份、黄荆17.5份、马钱子12.5份、丹皮17.5份、广木香17.5份和炒钩藤12.5份。
4.如权利要求1-3任一项所述的治疗宫颈癌的中药膏剂的制备方法，其特征在于，具体包括以下步骤：取所述重量份数的中药原料，向其中加入5-6倍中药原料重量的水，而后置于100℃下进行水煮30-60min，过滤获得滤液和药渣；向药渣中继续加入水于100℃下水煮30-60min；过滤获得滤液和药渣，重复水煮三次后；将三次过滤获得的滤液合并，进行浓缩处理后获得浓缩液；向浓缩液中添加调和剂制作成膏剂即得。
5.如权利要求4所述的治疗宫颈癌的中药膏剂的制备方法，其特征在于，所述的调和剂为蜂蜜或麦芽糖。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210268385.4A CN114796361A (zh) | 2022-03-18 | 2022-03-18 | 一种治疗宫颈癌的中药膏剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210268385.4A CN114796361A (zh) | 2022-03-18 | 2022-03-18 | 一种治疗宫颈癌的中药膏剂及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114796361A true CN114796361A (zh) | 2022-07-29 |
Family
ID=82531224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210268385.4A Pending CN114796361A (zh) | 2022-03-18 | 2022-03-18 | 一种治疗宫颈癌的中药膏剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114796361A (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464818A (zh) * | 2019-08-27 | 2019-11-19 | 贵州慈明堂健康管理有限公司 | 一种治疗宫颈癌的中药组合物 |
| CN111588780A (zh) * | 2020-07-09 | 2020-08-28 | 广西妙韵圆生药业有限公司 | 一种用于治疗宫颈hpv病毒感染的中药组合物及其制备方法 |
-
2022
- 2022-03-18 CN CN202210268385.4A patent/CN114796361A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464818A (zh) * | 2019-08-27 | 2019-11-19 | 贵州慈明堂健康管理有限公司 | 一种治疗宫颈癌的中药组合物 |
| CN111588780A (zh) * | 2020-07-09 | 2020-08-28 | 广西妙韵圆生药业有限公司 | 一种用于治疗宫颈hpv病毒感染的中药组合物及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 王菊光: "中医辨证治疗子宫颈癌42例分析", 《黑龙江中医药》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104983818A (zh) | 一种治疗妇科疾病的中药及其制备方法 | |
| CN104225441A (zh) | 一种治疗胃病的中药组合物及其颗粒剂和胶囊剂的制备方法 | |
| CN102284050B (zh) | 一种治疗宫寒不孕的中药组合物 | |
| CN101485803B (zh) | 一种治疗月经不调及痛经的中药组合物 | |
| CN101422536B (zh) | 一种治疗热盛肠燥型内痔的中药制备方法 | |
| CN104906519A (zh) | 一种治疗女性产后疾病的药物 | |
| CN103585453B (zh) | 一种治疗高血压的中药 | |
| CN104587206A (zh) | 治疗褥疮的药物及制备方法 | |
| CN101628056B (zh) | 一种治疗糖尿病性便秘的合剂 | |
| CN101700390B (zh) | 一种内服治疗脂肪肝的中药组合物 | |
| CN114796361A (zh) | 一种治疗宫颈癌的中药膏剂及其制备方法 | |
| CN100556434C (zh) | 一种治疗前列腺炎的药物及其制备方法 | |
| CN110812463A (zh) | 一种治疗盆腔炎的中药灌肠药剂及其制备方法 | |
| CN101125189A (zh) | 一种治疗肾病的中药及其制备方法 | |
| CN104547733A (zh) | 一种收白带的中药 | |
| CN103977363A (zh) | 一种治疗高血压的中药组合物 | |
| CN103599397B (zh) | 一种用于治疗慢性肾功能不全的中药组合物 | |
| CN103263645B (zh) | 一种治疗胃炎、胃溃疡的药物 | |
| CN108721422B (zh) | 一种用于霉菌性阴道炎治疗的药物组合物及其制备方法 | |
| CN105963619A (zh) | 一种治疗宫寒不孕的中药组合物 | |
| CN106266970B (zh) | 一种治疗生产引发子宫内膜炎的中药组合物 | |
| CN105456799A (zh) | 一种用于治疗小儿黄疸的中药洗液 | |
| CN104666880A (zh) | 一种治疗产后缺乳的护理药物 | |
| CN104352950A (zh) | 一种治疗妇科炎症的中药组合物 | |
| CN103585572B (zh) | 一种用于治疗子宫内膜异位的内服药物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220729 |