CN105963619A - 一种治疗宫寒不孕的中药组合物 - Google Patents
一种治疗宫寒不孕的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种治疗宫寒不孕的中药组合物，由以下重量份的原料组成，肉桂15‑20份，高良姜10‑13份，川芎10‑15份，玫瑰花8‑12份，代代花8‑10份，香橼13‑15份，山药10‑20份，巴戟天5‑10份，丹参6‑8份，黄芪10‑12份，香附5‑8份，阿胶12‑15份，两头尖6‑9份，老鹤草13‑15份，九空子5‑8份，鹿衔草3‑6份，葱子6‑10份。目前治疗宫寒不孕的药物主要从宫寒不孕的临床症状出发，缓解宫寒，提高受孕率，忽略了宫寒不孕的致病根本，目前，治疗中不同致病原因的宫寒没有特定的治疗药物，这样可能导致宫寒不孕缓解后，没有从根本上达到调理身体的目的，容易复发，使受孕后胎儿难以正常的发育或生存，容易出现不孕或流产等。
Description
技术领域
本发明属于中草药领域，尤其涉及一种治疗宫寒不孕的中药组合物。
背景技术
众所周知，“子宫寒冷”即宫寒，是中医理论下的病名，是指妇女肾阳不足，胞宫失于温煦所出现的一组症候群的病因总结。往往有下腹坠胀、疼痛、痛经得热则、水样白带等症状。临床常见于：月经失调、闭经、痛经、不孕、流产或妊娠后胎儿发育迟缓等病。临床上造成“宫寒”的原因很多，主要有一下几个方面：1、天生体质较寒，四肢容易冰冷，对气候转凉感应敏感，脸色苍白，喜欢喝热饮，很少口渴，冬天怕冷，夏天耐热；2、后天因素造成，居住环境寒冷、嗜好寒凉食物、过劳或易怒损伤身体阳气；3、遗传因素，父母体质偏寒，或者出生时由于父母年龄较大而身体阳气较少，致使后代在相同的条件下，容易出现宫寒的症状。
发明内容
提供一种治疗宫寒不孕的中药组合物。
一种治疗宫寒不孕的中药组合物，由以下重量份的原料组成，肉桂15-20份，高良姜10-13份，川芎10-15份，玫瑰花8-12份，代代花8-10份，香橼13-15份，山药10-20份，巴戟天5-10份，丹参6-8份，黄芪10-12份，香附5-8份，阿胶12-15份，两头尖6-9份，老鹤草13-15份，九空子5-8份，鹿衔草3-6份，葱子6-10份。
优选：一种治疗宫寒不孕的中药组合物，由以下重量份的原料组成，肉桂18-20份，高良姜11-13份，川芎12-13份，玫瑰花10-12份，代代花9-10份，香橼13-15份，山药15-18份，巴戟天6-8份，丹参6-8份，黄芪10-12份，香附7-8份，阿胶12-13份，两头尖6-8份，老鹤草13-14份，九空子5-7份，鹿衔草3-5份，葱子6-8份。
更优选：一种治疗宫寒不孕的中药组合物，由以下重量份的原料组成，肉桂20份，高良姜13份，川芎12份，玫瑰花11份，代代花9份，香橼14份，山药16份，巴戟天8份，丹参7份，黄芪11份，香附7份，阿胶13份，两头尖7份，老鹤草13份，九空子6份，鹿衔草4份，葱子8份。
上述的中药组合物在制备治疗宫寒不孕药物中的应用。
一种中药组合物的制备方法，以重量份计，原料由肉桂18-20份，高良姜11-13份，川芎12-13份，玫瑰花10-12份，代代花9-10份，香橼13-15份，山药15-18份，巴戟天6-8份，丹参6-8份，黄芪10-12份，香附7-8份，阿胶12-13份，两头尖6-8份，老鹤草13-14份，九空子5-7份，鹿衔草3-5份，葱子6-8份组成，取各重量份的药物，加入300ml水加热至100℃进行热浸提，15min后进行固液分离，收集滤液；加入200ml水进行二次热浸提，固液分离后，收集滤液，合并两次浸提液即可。
上述的制备方法制得的中药组合物。
一种中药制剂，由上述的中药组合物和药学上可接受的辅料组成，所述中药制剂的剂型为颗粒剂、胶囊剂、片剂、茶剂、口服液或滴丸剂。
在本发明提供的中药制剂中，药学上可接受的辅料为药物制剂中的常规辅料，如崩解剂、润滑剂、粘合剂等，但本发明中药学上可接受的辅料并不局限于此，本领域技术人员认为可行的常规辅料均在本发明的保护范围之内，本发明在此不做限定。在本发明中，中药制剂的制备方法为常规的制备方法。在本发明中，将本发明提供的中药组合物与不同剂型所需的药学上可接受的辅料混合，利用常规技术制成常用的口服制剂，本领域技术人员认为可行的制备方法均在本发明的保护范围之内，本发明在此不做限定。
我国中医药文化源远流长、博大精深，中药的配伍讲究相须、相使、相畏、相杀、相恶、相反。相须，即性能功效相类似的药物配合应用，可以增强其原有疗效；相使，即在性能功效方面有某种共性的药物配合应用，而以一种药物为主，另一种药物为辅，能提高主药的疗效；相畏指药物之间的相互抑制作用，药物的毒性或副作用能被另一种药物消减；相杀，即一种药物能减轻或消除另一种药物的毒性或副作用；相恶是指一种药物能使另一种药物原有功效降低，甚至消失；相反是指两种药物合用能产生或增强毒性反应或副作用的配伍关系。由于不同的中药之间存在着不同的配伍关系，因此在使用两味以上中药时，必须有所选择，充分发挥药物之间相须相使的配伍关系。本发明通过将各味中药的配伍，药物之间共同发挥了治疗气血两虚型体质的宫寒不孕的作用，具有明显的增效作用，充分发挥了相须相使的配伍关系，可有效治疗宫寒不孕。下面分别介绍一下各味中药的功效及主治症：
肉桂：【性味与归经】辛、甘，大热。归肾、脾、心、肝经。【功能与主治】补火助阳，引火归元，散寒止痛，温通经脉。用于阳痿宫冷，腰膝冷痛，肾虚作喘，虚阳上浮，眩晕目赤，心腹冷痛，虚寒吐泻，寒疝腹痛，痛经经闭。
高良姜：【性味与归经】辛，热。归脾、胃经。【功能与主治】温胃止呕，散寒止痛。用于脘腹冷痛，胃寒呕吐，嗳气吞酸。
川芎：【性味与归经】辛，温。归肝、胆、心包经。【功能与主治】活血行气，祛风止痛。用于胸痹心痛，胸胁刺痛，跌扑肿痛，月经不调，经闭痛经，癥瘕腹痛，头痛，风湿痹痛。
玫瑰花：【性味与归经】甘、微苦，温。归肝、脾经。【功能与主治】行气解郁，和血，止痛。用于肝胃气痛，食少呕恶，月经不凋，跌扑伤痛。
代代花：味苦、酸，性微寒。主治行气宽中，消食，化痰。用于胸腹闷胀痛、食积不化、痰饮、脱肛。
香橼：性味与归经】辛、苦、酸，温。归肝、脾、肺经。【功能与主治】疏肝理气，宽中，化痰。用于肝胃气滞，胸胁胀痛，脘腹痞满，呕吐噫气，痰多咳嗽。
山药：【性味与归经】甘，平。归脾、肺、肾经。【功能与主治】补脾养胃，生津益肺，补肾涩精。用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。麸炒山药补脾健胃。用于脾虚食少，泄泻便溏，白带过多。
巴戟天：【性味与归经】甘、辛，微温。归肾、肝经。【功能与主治】补肾阳，强筋骨，祛风湿。用于阳痿遗精，宫冷不孕，月经不调，少腹冷痛，风湿痹痛，筋骨痿软。
丹参：【性味与归经】苦，微寒。归心、肝经。【功能与主治】活血祛瘀，通经止痛，清心除烦，凉血消痈。用于胸痹心痛，脘腹胁痛，癥瘕积聚，热痹疼痛，心烦不眠，月经不调，痛经经闭，疮疡肿痛。
黄芪：【性味与归经】甘，微温。归肺、脾经。【功能与主治】补气升阳，固表止汗，利水消肿，生津养血，行滞通痹，托毒排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，内热消渴，血虚萎黄，半身不遂，痹痛麻木，痈疽难溃，久溃不敛。
香附：【性味与归经】辛、微苦、微甘，平。归肝、脾、三焦经。【功能与主治】疏肝解郁，理气宽中，调经止痛。用于肝郁气滞，胸胁胀痛，疝气疼痛，乳房胀痛，脾胃气滞，脘腹痞闷，胀满疼痛，月经不调，经闭痛经。
阿胶：【性味与归经】甘，平。归肺、肝、肾经。【功能与主治】补血滋阴，润燥，止血。用于血虚萎黄，眩晕心悸，肌痿无力，心烦不眠，虚风内动，肺燥咳嗽，劳嗽咯血，吐血尿血，便血崩漏，妊娠胎漏。
两头尖：【性味与归经】辛，热；有毒。归脾经。功能与主治】祛风湿，消痈肿。用于风寒湿痹，四肢拘挛，骨节疼痛，痈肿溃烂。
老鹤草：【性味与归经】辛、苦，平。归肝、肾、脾经。【功能与主治】祛风湿，通经络，止泻痢。用于风湿痹痛，麻木拘挛，筋骨酸痛，泄泻痢疾。
九空子：别名：路路通，【性味与归经】苦，平。归肝、肾经。【功能与主治】祛风活络，利水，通经。用于关节痹痛，麻木拘挛，水肿胀满，乳少，经闭。
鹿衔草：【性味与归经】甘、苦，温。归肝、肾经。【功能与主治】祛风湿，强筋骨，止血，止咳。用于风湿痹痛，肾虚腰痛，腰膝无力，月经过多，久咳劳嗽。
葱子：【功能主治】补肾明目，用于肾虚、阳痿、目眩。
本发明的有益效果：
目前治疗宫寒不孕的药物主要从宫寒不孕的临床症状出发，缓解宫寒，提高受孕率，忽略了宫寒不孕的致病根本，目前，治疗不同致病原因的宫寒没有特定的治疗药物，这样可能导致宫寒不孕缓解后，没有从根本上达到调理身体的目的，容易复发，使受孕后胎儿难以正常的生长发育或生存，出现不孕或流产等。
本发明的药物以肉桂、山药、高良姜、川芎为君药，玫瑰花、代代花、香橼、阿胶、老鹤草、黄芪为臣药，其它组份为辅药，各组份相辅相成，起到取长补短、增进功效、减低毒副作用的效果，能够达到安全有效治疗宫寒不孕的目的。
本发明的药物治疗气血两虚型宫寒不孕效果好，温阳化气，固本添精，调理冲任，调畅气血、改善血液循环，使全身温暖。
本发明药物能够改善较寒体质，疏通经脉，保护并滋养子宫内膜，提高受孕几率，为胎儿的生长发育提供一个健康稳定的环境，避免了孕后流产等症状。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1
取肉桂20份，高良姜13份，川芎12份，玫瑰花11份，代代花9份，香橼14份，山药16份，巴戟天8份，丹参7份，黄芪11份，香附7份，阿胶13份，两头尖7份，老鹤草13份，九空子6份，鹿衔草4份，葱子8份混合均匀，取以上药物，加入300ml水加热至100℃进行热浸提，15min后进行固液分离，收集滤液；加入200ml水进行二次热浸提，固液分离后，收集滤液，合并两次浸提液，一日分两次服。
实施例2
肉桂15份，高良姜10份，川芎15份，玫瑰花12份，代代花10份，香橼13份，山药10份，巴戟天10份，丹参8份，黄芪10份，香附5份，阿胶15份，两头尖9份，老鹤草15份，九空子8份，鹿衔草3份，葱子10份混合均匀，取以上药物，加入300ml水加热至100℃进行热浸提，15min后进行固液分离，收集滤液；加入200ml水进行二次热浸提，固液分离后，收集滤液，合并两次浸提液，一日分两次服。
实施例3
肉桂20份，高良姜13份，川芎10份，玫瑰花8份，代代花8份，香橼15份，山药20份，巴戟天5份，丹参6份，黄芪12份，香附8份，阿胶12份，两头尖6份，老鹤草15份，九空子5份，鹿衔草6份，葱子6份混合均匀，取以上药物，加入300ml水加热至100℃进行热浸提，15min后进行固液分离，收集滤液；加入200ml水进行二次热浸提，固液分离后，收集滤液，合并两次浸提液，一日分两次服。
实施例4
肉桂18份，高良姜11份，川芎12份，玫瑰花12份，代代花10份，香橼13份，山药15份，巴戟天8份，丹参6份，黄芪10份，香附8份，阿胶13份，两头尖8份，老鹤草13份，九空子5份，鹿衔草5份，葱子6份混合均匀，取以上药物，加入300ml水加热至100℃进行热浸提，15min后进行固液分离，收集滤液；加入200ml水进行二次热浸提，固液分离后，收集滤液，合并两次浸提液，一日分两次服。
实施例5
肉桂20份，高良姜13份，川芎13份，玫瑰花12份，代代花9份，香橼15份，山药18份，巴戟天6份，丹参8份，黄芪10份，香附8份，阿胶12份，两头尖8份，老鹤草14份，九空子5份，鹿衔草3份，葱子8份混合均匀，取以上药物，加入300ml水加热至100℃进行热浸提，15min后进行固液分离，收集滤液；加入200ml水进行二次热浸提，固液分离后，收集滤液，合并两次浸提液，一日分两次服。
下面结合临床试验数据说明本发明的有益效果：
1、一般资料
2013年2月-2015年12月间，发明人共收集150例宫寒不孕患者，年龄22-40岁，不孕年限3-10年。
2、治疗方法
每天早晚两次服用本发明如具体实施例1所述方法制得的煎剂，预计经前7天开始服用，1个疗程连续7天，连续服用3个疗程。治疗前后中医诊断患者宫寒状态改善情况；治疗后定期观察患者半年内的妊娠状态。
3、疗效标准
痊愈：治疗后宫寒现象消失，秋冬季节手脚温暖，治疗半年内妊娠。
好转：虽未妊娠，但治疗后宫寒状态显著改善。
无效：宫寒状态无明显好转或加重。
4、治疗结果
治疗统计结果见表1。
表1治疗统计结果
| n | 痊愈 | 好转 | 无效 | 不良反应 | 总有效率 |
| 150 | 81(54％) | 63(42％) | 6(4％) | 0(0％) | 96％ |
由表1可见，本发明的药物组合物对气血两虚型宫寒不孕者具有很好的作用，对痊愈者进行随访，无一例出现流产的症状，胎儿生长发育正常。
上述虽然对本发明的具体实施方式进行了描述，但并非对本发明保护范围的限制，所属领域技术人员应该明白，在本发明的技术方案的基础上，本领域技术人员不需要付出创造性劳动即可做出的各种修改或变形仍在本发明的保护范围以内。
Claims (8)
1.一种治疗宫寒不孕的中药组合物，其特征是：由以下重量份的原料组成，肉桂15-20份，高良姜10-13份，川芎10-15份，玫瑰花8-12份，代代花8-10份，香橼13-15份，山药10-20份，巴戟天5-10份，丹参6-8份，黄芪10-12份，香附5-8份，阿胶12-15份，两头尖6-9份，老鹤草13-15份，九空子5-8份，鹿衔草3-6份，葱子6-10份。
2.如权利要求1所述的一种治疗宫寒不孕的中药组合物，其特征是：由以下重量份的原料组成，肉桂18-20份，高良姜11-13份，川芎12-13份，玫瑰花10-12份，代代花9-10份，香橼13-15份，山药15-18份，巴戟天6-8份，丹参6-8份，黄芪10-12份，香附7-8份，阿胶12-13份，两头尖6-8份，老鹤草13-14份，九空子5-7份，鹿衔草3-5份，葱子6-8份。
3.如权利要求1所述的一种治疗宫寒不孕的中药组合物，其特征是：由以下重量份的原料组成，肉桂20份，高良姜13份，川芎12份，玫瑰花11份，代代花9份，香橼14份，山药16份，巴戟天8份，丹参7份，黄芪11份，香附7份，阿胶13份，两头尖7份，老鹤草13份，九空子6份，鹿衔草4份，葱子8份。
4.权利要求1-3任一所述的中药组合物在制备治疗宫寒不孕药物中的应用。
5.一种中药组合物的制备方法，其特征是：以重量份计，原料由肉桂18-20份，高良姜11-13份，川芎12-13份，玫瑰花10-12份，代代花9-10份，香橼13-15份，山药15-18份，巴戟天6-8份，丹参6-8份，黄芪10-12份，香附7-8份，阿胶12-13份，两头尖6-8份，老鹤草13-14份，九空子5-7份，鹿衔草3-5份，葱子6-8份组成，取各重量份的药物，加入300ml水加热至100℃进行热浸提，15min后进行固液分离，收集滤液；加入200ml水进行二次热浸提，固液分离后，收集滤液，合并两次浸提液即可。
6.权利要求5所述的制备方法制得的中药组合物。
7.一种中药制剂，其特征是：由权利要求1-3任一所述的中药组合物和药学上可接受的辅料组成。
8.如权利要求7所述的中药制剂，其特征是：所述中药制剂的剂型为颗粒剂、胶囊剂、片剂、茶剂、口服液或滴丸剂。
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