CN114788799A - Skin-beautifying cosmetic - Google Patents
Skin-beautifying cosmetic Download PDFInfo
- Publication number
- CN114788799A CN114788799A CN202210391975.6A CN202210391975A CN114788799A CN 114788799 A CN114788799 A CN 114788799A CN 202210391975 A CN202210391975 A CN 202210391975A CN 114788799 A CN114788799 A CN 114788799A
- Authority
- CN
- China
- Prior art keywords
- parts
- skin
- weight
- filtrate
- filtering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 64
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 93
- 239000000284 extract Substances 0.000 claims abstract description 46
- 235000012871 Arctostaphylos uva ursi Nutrition 0.000 claims abstract description 32
- 244000003892 Vaccinium erythrocarpum Species 0.000 claims abstract description 32
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 28
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 26
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229940119217 chamomile extract Drugs 0.000 claims abstract description 25
- 235000020221 chamomile extract Nutrition 0.000 claims abstract description 25
- 239000002904 solvent Substances 0.000 claims abstract description 20
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 19
- 239000000516 sunscreening agent Substances 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 13
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 13
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 13
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 13
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 13
- 239000000230 xanthan gum Substances 0.000 claims abstract description 13
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 13
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 13
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 68
- 239000000706 filtrate Substances 0.000 claims description 58
- 238000002156 mixing Methods 0.000 claims description 46
- 239000000243 solution Substances 0.000 claims description 42
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 40
- 238000001914 filtration Methods 0.000 claims description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
- 238000010438 heat treatment Methods 0.000 claims description 32
- 238000003756 stirring Methods 0.000 claims description 31
- 239000002244 precipitate Substances 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 24
- 238000010992 reflux Methods 0.000 claims description 22
- QWXYZCJEXYQNEI-OSZHWHEXSA-N intermediate I Chemical compound COC(=O)[C@@]1(C=O)[C@H]2CC=[N+](C\C2=C\C)CCc2c1[nH]c1ccccc21 QWXYZCJEXYQNEI-OSZHWHEXSA-N 0.000 claims description 18
- 238000005406 washing Methods 0.000 claims description 17
- 239000007864 aqueous solution Substances 0.000 claims description 16
- 239000003623 enhancer Substances 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 14
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 239000000787 lecithin Substances 0.000 claims description 12
- 229940067606 lecithin Drugs 0.000 claims description 12
- 235000010445 lecithin Nutrition 0.000 claims description 12
- 238000002791 soaking Methods 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- 230000001376 precipitating effect Effects 0.000 claims description 10
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 8
- 239000007789 gas Substances 0.000 claims description 8
- 229910000037 hydrogen sulfide Inorganic materials 0.000 claims description 8
- 229940046892 lead acetate Drugs 0.000 claims description 8
- 230000007935 neutral effect Effects 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 229920006395 saturated elastomer Polymers 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 7
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 6
- 239000004166 Lanolin Substances 0.000 claims description 6
- 229910021536 Zeolite Inorganic materials 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 6
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 6
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 6
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 6
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 6
- 235000019388 lanolin Nutrition 0.000 claims description 6
- 229940039717 lanolin Drugs 0.000 claims description 6
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 6
- 239000003208 petroleum Substances 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- 229940073490 sodium glutamate Drugs 0.000 claims description 6
- 239000010457 zeolite Substances 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- MEINCZCLWIPDPV-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;4-phenyl-1h-benzimidazole-2-sulfonic acid Chemical compound OCCN(CCO)CCO.C1=CC=C2NC(S(=O)(=O)O)=NC2=C1C1=CC=CC=C1 MEINCZCLWIPDPV-UHFFFAOYSA-N 0.000 claims description 4
- 235000013871 bee wax Nutrition 0.000 claims description 4
- 239000012166 beeswax Substances 0.000 claims description 4
- -1 polyoxyethylene Polymers 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 3
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims description 2
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims description 2
- 229940068171 ethyl hexyl salicylate Drugs 0.000 claims description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims 1
- 229910000881 Cu alloy Inorganic materials 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- GEOHSPSFYNRMOC-UHFFFAOYSA-N alumane;copper Chemical compound [AlH3].[Cu].[Cu] GEOHSPSFYNRMOC-UHFFFAOYSA-N 0.000 claims 1
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 claims 1
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims 1
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 claims 1
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 claims 1
- 229960000655 ensulizole Drugs 0.000 claims 1
- 229940075507 glyceryl monostearate Drugs 0.000 claims 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 abstract description 7
- 239000000232 Lipid Bilayer Substances 0.000 abstract description 6
- 210000001723 extracellular space Anatomy 0.000 abstract description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract description 2
- 229960004365 benzoic acid Drugs 0.000 abstract 1
- 229960005150 glycerol Drugs 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 50
- 230000000052 comparative effect Effects 0.000 description 28
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 22
- 244000042664 Matricaria chamomilla Species 0.000 description 22
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 22
- 238000012360 testing method Methods 0.000 description 16
- 239000000287 crude extract Substances 0.000 description 13
- 230000003020 moisturizing effect Effects 0.000 description 13
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 12
- 229920002674 hyaluronan Polymers 0.000 description 12
- 229960003160 hyaluronic acid Drugs 0.000 description 12
- 150000002632 lipids Chemical class 0.000 description 12
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 10
- 238000000967 suction filtration Methods 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 8
- 238000009792 diffusion process Methods 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 210000000434 stratum corneum Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 6
- 229940056932 lead sulfide Drugs 0.000 description 6
- 229910052981 lead sulfide Inorganic materials 0.000 description 6
- 235000009048 phenolic acids Nutrition 0.000 description 5
- 150000007965 phenolic acids Chemical class 0.000 description 5
- 102000003425 Tyrosinase Human genes 0.000 description 4
- 108060008724 Tyrosinase Proteins 0.000 description 4
- 239000002131 composite material Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229930003935 flavonoid Natural products 0.000 description 4
- 150000002215 flavonoids Chemical class 0.000 description 4
- 235000017173 flavonoids Nutrition 0.000 description 4
- 229940093915 gynecological organic acid Drugs 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- 235000005985 organic acids Nutrition 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000001291 vacuum drying Methods 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229960000271 arbutin Drugs 0.000 description 3
- 239000002021 butanolic extract Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 230000003467 diminishing effect Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 3
- 235000018553 tannin Nutrition 0.000 description 3
- 229920001864 tannin Polymers 0.000 description 3
- 239000001648 tannin Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000003255 anti-acne Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000011449 brick Substances 0.000 description 2
- 229940106189 ceramide Drugs 0.000 description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241000121220 Tricholoma matsutake Species 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- NKMGOVFBDKQFQY-UHFFFAOYSA-N [Cu].[Ni].[Cu].[Mn] Chemical compound [Cu].[Ni].[Cu].[Mn] NKMGOVFBDKQFQY-UHFFFAOYSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 150000004775 coumarins Chemical class 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention relates to the technical field of cosmetics, in particular to a skin-beautifying cosmetic which is prepared from the following raw materials: the skin-care cosmetic comprises chamomile extract, bearberry leaf extract, a penetration enhancer, 1, 3-propylene glycol, glycerol, ascorbic acid, xanthan gum, benzoic acid, an emulsifier, a sun-screening agent and a solvent, wherein the prepared penetration enhancer contains phosphate groups and can be easily diffused through a lipid bilayer in intercellular spaces, so that the prepared cosmetic has high moisture retention and high transdermal property and can effectively brighten skin color.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a skin-beautifying cosmetic.
Background
The cosmetic is a chemical industrial product or a fine chemical product which is spread on any part of the surface of a human body, such as skin, hair, nails, lips and teeth, by a painting, spraying or other similar method, so as to achieve the purposes of cleaning, maintaining, beautifying, modifying and changing the appearance, or correcting the odor of the human body, and maintaining a good state, and the transdermal absorption in the cosmetic refers to a process in which functional ingredients in the cosmetic act on the surface of the skin or enter epidermis or dermis according to the effectiveness of the product, and accumulate and function at the part. Transdermal absorption of cosmetic benefit agents does not require penetration through the skin into the systemic circulation, which is a major difference from drugs.
Chinese patent application No. 200810028203.6 discloses a cosmetic composition for whitening skin, the active components of which comprise licorice extract, matsutake mushroom extract, vitamin C or its derivatives, and vitamin B3. The natural extract is used as a main raw material, the vitamin active additive is compounded, and the effects of inhibiting the generation of melanin and lightening skin color are achieved through various ways by utilizing the reasonable combination and matching of various components.
Chinese patent application No. 201210407992.0 discloses a skin cosmetic prepared from the following materials: the skin whitening cream comprises hyaluronic acid, an amino acid whitening agent, essence, a moisturizing agent, an antifreeze agent, a preservative, a lubricant, a solubilizer and the balance of water, can supplement water and nutrition while whitening the skin and adjust the water-oil balance of the skin, selects mild and safe components such as corn oil extract, moisturizing factor hyaluronic acid and ceramide similar to the skin in composition structure, and can moisturize and clean the white skin, improve the roughness and dullness of the skin, and improve the skin glossiness and whiteness.
Disclosure of Invention
In order to solve the problems, the invention prepares the skin-beautifying cosmetic, and the prepared cosmetic has the effects of adjusting uneven skin color and brightening the skin color by adding the chamomile extract and the bearberry leaf extract into the cosmetic, and simultaneously has better moisturizing capability and diffusion and absorption capability.
The technical scheme for solving the problems is as follows:
a skin cosmetic comprises flos Matricariae Chamomillae extract and folium Vaccinii Vitis-idaeae extract;
the preparation method of the chamomile extract comprises the following steps: pulverizing cleaned and dried flos Matricariae Chamomillae, grinding, sieving, soaking in ethanol solution, heating under reflux, collecting extractive solution, centrifuging, vacuum filtering, dissolving in deionized water, and extracting with n-butanol;
the preparation method of the bearberry leaf extract comprises the following steps: cleaning leaves of bearberry, pulverizing, soaking in ethanol solution for extraction, filtering the extractive solution, washing, mixing filtrates, treating the filtrate with saturated neutral lead acetate aqueous solution, filtering to obtain precipitate, precipitating the filtrate with alkaline lead aqueous solution, filtering to remove precipitate, suspending in distilled water, introducing hydrogen sulfide gas into the suspension to generate precipitate, vacuum filtering, washing the filtrate with water, mixing filtrates, and concentrating the filtrate under reduced pressure.
The invention has the following beneficial effects:
1. in the process of preparing the chamomile extract, the crushed chamomile is soaked in an ethanol solution, heated and refluxed, and extracted by using a method of extracting n-butyl alcohol, so that the chamomile extract has the effects of resisting allergy, diminishing inflammation, resisting oxidation, resisting virus, inhibiting bacteria, relieving spasm, treating ulcer, clearing heat, resisting vascular proliferation and the like, and can play a good role in repairing sensitive skin, reducing fine red blood streaks, reducing redness and adjusting uneven skin color;
2. in the process of preparing the bearberry leaf extract, the bearberry leaf extract is soaked in an ethanol solution, after extraction, saturated neutral lead acetate aqueous solution and alkaline lead aqueous solution are used for precipitation, hydrogen sulfide gas is introduced into suspension to generate colloidal lead sulfide precipitate, and the filtrate is subjected to suction filtration and reduced pressure concentration to obtain the bearberry leaf extract, so that the activity of tyrosinase in the skin can be effectively inhibited, the formation of melanin is blocked, and the decomposition and excretion of the melanin are accelerated by directly combining the extract with the tyrosinase, so that the skin pigmentation is reduced;
3. one end of the prepared transdermal enhancer contains phosphate group, the stratum corneum is composed of corneocytes and intercellular lipid, and can be easily diffused through lipid bilayers in intercellular gaps, when the molecules are inserted into a lipid bilayer hydrophobic structure of the stratum corneum lipid, due to the existence of a long-chain structure, the bilayers are twisted to form a fine and easily-permeable flowing channel, so that the ordered arrangement of the stratum corneum lipid structure is effectively influenced, the diffusion resistance is reduced, and the diffusion and absorption of related components are promoted.
Drawings
Fig. 1 is a result of a moisturizing effect test of the cosmetic according to the present invention.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Example 1
A skin cosmetic comprises flos Matricariae Chamomillae extract and folium Vaccinii Vitis-idaeae extract;
the preparation method of the chamomile extract comprises the following steps: taking cleaned and dried chamomile 16 parts by weight, grinding, sieving with a 150-mesh sieve, soaking the sieved material in 60% ethanol solution, heating and refluxing for 3 hours at 55 ℃, repeating the heating and refluxing for two times, collecting and combining extracting solutions, centrifuging and performing suction filtration to obtain a chamomile crude extract, dissolving the chamomile crude extract in deionized water, and extracting the chamomile crude extract by using n-butyl alcohol, wherein the method specifically comprises the following steps: adding 180ml of n-butanol into the crude extract of flos Matricariae Chamomillae, extracting under shaking, separating n-butanol extractive solution and water phase extractive solution to obtain n-butanol phase, and vacuum drying.
The preparation method of the bearberry leaf extract comprises the following steps: washing 18 parts by weight of leaves of bearberry, crushing, soaking in 60% ethanol solution for extraction, filtering the extract, combining the filtrates after washing, treating the filtrate with saturated neutral lead acetate aqueous solution, precipitating organic acids, phenolic acids, tannic acids and flavonoids therein to generate insoluble lead salt precipitate, filtering out the precipitate, precipitating the filtrate with alkaline lead aqueous solution, filtering out the precipitate, suspending the precipitate in distilled water, introducing hydrogen sulfide gas into the suspension to generate colloidal lead sulfide precipitate, performing suction filtration, washing the filtrate with water, combining the filtrates, and concentrating the filtrate under reduced pressure to obtain the compound.
A skin-beautifying cosmetic is prepared from the following raw materials in parts by weight: 12 parts of chamomile extract, 12 parts of bearberry leaf extract, 5 parts of transdermal enhancer, 18 parts of 1, 3-propylene glycol, 35 parts of glycerol, 3 parts of ascorbic acid, 3 parts of xanthan gum, 2 parts of benzoic acid, 4 parts of emulsifier, 1 part of sun-screening agent and 450 parts of solvent.
Wherein, the preparation process of the penetration enhancer is as follows:
t1, adding 10 parts by weight of phosphoric acid into 15 parts by weight of glycerol, adding 6 parts by weight of petroleum ether into the glycerol, starting a stirring device, raising the temperature to 65 ℃, reacting for 4 hours, and then heating and refluxing to obtain an intermediate I, wherein the reaction process is as follows:
t2, adding 15 parts by weight of sodium glutamate into 20 parts by weight of glycerol, uniformly mixing, adding 5 parts by weight of zeolite and 3 parts by weight of sodium carbonate, raising the temperature to 130 ℃, reacting for 4 hours, stopping heating and stirring, standing for layering, separating a lower water layer, dropwise adding 12 parts by weight of hydrochloric acid into the mixture under a stirring state, reacting for 2 hours, filtering, evaporating and drying the filtrate, dropwise adding an ethanol solution into the filtrate, crystallizing, filtering and drying to obtain an intermediate II, wherein the reaction process is as follows:
t3, mixing 15 parts by weight of the intermediate I and 15 parts by weight of the intermediate II, adding 5 parts by weight of copper sulfate and 13 parts by weight of cyclohexane, starting stirring, raising the temperature to 110 ℃, reacting for 6 hours, filtering, and heating and refluxing the filtrate to obtain the copper-nickel-copper-manganese composite material, wherein the reaction process is as follows:
wherein the emulsifier is lecithin, the sun-screening agent is bis-ethylhexyloxyphenol methoxyphenyl triazine, and the solvent is deionized water.
A skin makeup cosmetic comprising the steps of:
s1, mixing 18 parts by weight of 1, 3-propylene glycol, 35 parts by weight of glycerol, 3 parts by weight of ascorbic acid, 1 part by weight of sun-screening agent and 450 parts by weight of solvent according to the parts by weight of the raw materials, heating to 40 ℃, and uniformly stirring;
and S2, mixing 12 parts by weight of chamomile extract and 12 parts by weight of bearberry leaf extract, adding the mixture into the solution obtained in the step S1, adding 5 parts by weight of penetration enhancer, 2 parts by weight of benzoic acid and 4 parts by weight of emulsifier in sequence after uniformly mixing, adding 3 parts by weight of xanthan gum after uniformly mixing to adjust the viscosity, and uniformly mixing to obtain the anti-acne and anti-acne gel.
Example 2
Compared with the example 1, the skin-beautifying cosmetic has different raw material compositions and proportions, different extraction conditions of the composition and unchanged other conditions, and specifically comprises the following steps:
a skin cosmetic comprises flos Matricariae Chamomillae extract and folium Vaccinii Vitis-idaeae extract;
the preparation method of the chamomile extract comprises the following steps: 20 parts by weight of cleaned and dried chamomile is taken, crushed and ground, and sieved by a 150-mesh sieve, the sieved substance is soaked in a 60% ethanol solution, the heating reflux is carried out for 3 hours at 55 ℃, the two times are repeated, the extracting solution is collected and combined, the centrifugation and the suction filtration are carried out, so as to obtain the chamomile crude extract, the chamomile crude extract is dissolved in deionized water, and the extraction is carried out by using n-butyl alcohol, wherein the specific steps are as follows: adding 180ml of n-butanol into the crude extract of chamomile, performing shaking extraction, separating n-butanol extract from water phase extract to obtain n-butanol phase, and vacuum drying.
The preparation method of the bearberry leaf extract comprises the following steps: washing 25 parts by weight of bearberry leaves, crushing, soaking in 60% ethanol solution for extraction, filtering the extract, washing, combining the filtrates, treating the filtrate with saturated neutral lead acetate aqueous solution, precipitating the organic acids, phenolic acids, tannins and flavonoids in the filtrate to generate insoluble lead salt precipitate, filtering out the precipitate, precipitating the filtrate with alkaline lead aqueous solution, filtering out the precipitate, suspending the precipitate in distilled water, introducing hydrogen sulfide gas into the suspension to generate colloidal lead sulfide precipitate, performing suction filtration, washing the filtrate with water, combining the filtrates, and concentrating the filtrate under reduced pressure to obtain the compound.
A skin-beautifying cosmetic is prepared from the following raw materials in parts by weight: 16 parts of chamomile extract, 16 parts of bearberry leaf extract, 8 parts of transdermal enhancer, 22 parts of 1, 3-propylene glycol, 44 parts of glycerol, 5 parts of ascorbic acid, 5 parts of xanthan gum, 4 parts of benzoic acid, 6 parts of emulsifier, 4 parts of sun-screening agent and 500 parts of solvent.
Wherein, the preparation process of the penetration enhancer is as follows:
t1, adding 12 parts by weight of phosphoric acid into 16 parts by weight of glycerol, adding 6 parts by weight of petroleum ether into the glycerol, starting a stirring device, raising the temperature to 75 ℃, reacting for 6 hours, and heating and refluxing to obtain an intermediate I;
t2, adding 16 parts by weight of sodium glutamate into 22 parts by weight of glycerol, uniformly mixing, adding 6 parts by weight of zeolite and 4 parts by weight of sodium carbonate, raising the temperature to 150 ℃, stopping heating and stirring after 6 hours of reaction, standing for layering, separating a lower water layer, dropwise adding 14 parts by weight of hydrochloric acid into the mixture under a stirring state, filtering after 4 hours of reaction, evaporating and drying the filtrate, dropwise adding an ethanol solution into the filtrate, and crystallizing, filtering and drying to obtain an intermediate II;
t3, mixing 16 parts by weight of the intermediate I and 16 parts by weight of the intermediate II, adding 7 parts by weight of copper sulfate and 15 parts by weight of cyclohexane, starting stirring, raising the temperature to 120 ℃, reacting for 6 hours, filtering, and heating and refluxing the filtrate to obtain the copper-aluminum-copper-manganese-zinc-manganese composite material.
Wherein the emulsifier is lanolin, the sunscreen agent is ethylhexyl salicylate, and the solvent is distilled water.
A skin-beautifying cosmetic comprises the following steps:
s1, mixing 22 parts by weight of 1, 3-propylene glycol, 44 parts by weight of glycerol, 5 parts by weight of ascorbic acid, 4 parts by weight of sun-screening agent and 500 parts by weight of solvent according to the parts by weight of the raw materials, heating to 50 ℃, and uniformly stirring;
s2, mixing 16 parts by weight of chamomile extract and 16 parts by weight of bearberry leaf extract, adding the mixture into the solution obtained in the step S1, uniformly mixing, sequentially adding 8 parts by weight of penetration enhancer, 4 parts by weight of benzoic acid and 6 parts by weight of emulsifier, uniformly mixing, adding 5 parts by weight of xanthan gum to adjust the viscosity, and uniformly mixing to obtain the anti-cancer drug.
Example 3
Compared with the example 1, the skin-beautifying cosmetic has different raw material compositions and proportions, different composition extraction conditions and unchanged other conditions, and specifically comprises the following steps:
a skin cosmetic comprises flos Matricariae Chamomillae extract and folium Vaccinii Vitis-idaeae extract;
the preparation method of the chamomile extract comprises the following steps: crushing and grinding 18 parts by weight of cleaned and dried chamomile, sieving with a 150-mesh sieve, soaking the sieved product in a 60% ethanol solution, heating and refluxing for 3 hours at 55 ℃, repeating twice, collecting and combining extracting solutions, centrifuging and performing suction filtration to obtain a chamomile crude extract, dissolving the chamomile crude extract in deionized water, and extracting with n-butyl alcohol, wherein the method specifically comprises the following steps: adding 180ml of n-butanol into the crude extract of chamomile, performing shaking extraction, separating n-butanol extract from water phase extract to obtain n-butanol phase, and vacuum drying.
The preparation method of the bearberry leaf extract comprises the following steps: washing 23 parts by weight of bearberry leaves, crushing, soaking in 60% ethanol solution for extraction, filtering the extract, washing, combining the filtrates, treating the filtrate with saturated neutral lead acetate aqueous solution, precipitating the organic acids, phenolic acids, tannins and flavonoids in the filtrate to generate insoluble lead salt precipitate, filtering out the precipitate, precipitating the filtrate with alkaline lead aqueous solution, filtering out the precipitate, suspending the precipitate in distilled water, introducing hydrogen sulfide gas into the suspension to generate colloidal lead sulfide precipitate, performing suction filtration, washing the filtrate with water, combining the filtrates, and concentrating the filtrate under reduced pressure to obtain the compound.
A skin-beautifying cosmetic is prepared from the following raw materials in parts by weight: 14 parts of chamomile extract, 14 parts of bearberry leaf extract, 6 parts of transdermal enhancer, 20 parts of 1, 3-propylene glycol, 38 parts of glycerol, 4 parts of ascorbic acid, 4 parts of xanthan gum, 3 parts of benzoic acid, 5 parts of emulsifier, 2 parts of sun-screening agent and 480 parts of solvent.
Wherein, the preparation process of the penetration enhancer is as follows:
t1, adding 12 parts by weight of phosphoric acid into 16 parts by weight of glycerol, adding 6 parts by weight of petroleum ether into the glycerol, starting a stirring device, raising the temperature to 70 ℃, reacting for 5 hours, and heating and refluxing to obtain an intermediate I;
t2, adding 16 parts by weight of sodium glutamate into 22 parts by weight of glycerol, uniformly mixing, adding 6 parts by weight of zeolite and 4 parts by weight of sodium carbonate, raising the temperature to 135 ℃, reacting for 5 hours, stopping heating and stirring, standing for layering, separating a lower water layer, dropwise adding 14 parts by weight of hydrochloric acid into the mixture under a stirring state, reacting for 4 hours, filtering, evaporating and drying the filtrate, dropwise adding an ethanol solution into the filtrate, crystallizing, filtering and drying to obtain an intermediate II;
t3, mixing 16 parts by weight of the intermediate I and 16 parts by weight of the intermediate II, adding 7 parts by weight of copper sulfate and 15 parts by weight of cyclohexane, starting stirring, raising the temperature to 110 ℃, reacting for 6 hours, filtering, and heating and refluxing the filtrate to obtain the copper-aluminum-copper-manganese-zinc-manganese composite material.
Wherein, the emulsifier is lanolin and beeswax according to the weight ratio of 1: 1, the sun-screening agent is phenyl benzimidazole sulfonic acid triethanolamine, and the solvent is deionized water.
A skin makeup cosmetic comprising the steps of:
s1, mixing 20 parts by weight of 1, 3-propylene glycol, 38 parts by weight of glycerol, 4 parts by weight of ascorbic acid, 2 parts by weight of sun-screening agent and 480 parts by weight of solvent according to the parts by weight of the raw materials, heating to 45 ℃, and uniformly stirring;
s2, mixing 14 parts by weight of chamomile extract and 14 parts by weight of bearberry leaf extract, adding the mixture into the solution obtained in the step S1, uniformly mixing, sequentially adding 6 parts by weight of penetration enhancer, 3 parts by weight of benzoic acid and 5 parts by weight of emulsifier, uniformly mixing, adding 4 parts by weight of xanthan gum to adjust the viscosity, and uniformly mixing to obtain the anti-cancer drug.
Comparative example 1
Compared with the example 3, the prepared intermediate I is used as a penetration enhancer, the rest components are unchanged, and the preparation method is prepared according to the method of the example 3.
Comparative example 2
Compared with the example 3, the prepared intermediate II is used as a penetration enhancer, the rest of the composition is unchanged, and the preparation method is prepared according to the method of the example 3.
Comparative example 3
The permeation enhancer was replaced with commercial hyaluronic acid compared with example 3, and the remaining composition was unchanged, and the preparation method was performed according to the method of example 3.
Comparative example 4
In comparison with example 3, commercial lecithin was used as a permeation enhancer, and the remaining composition was unchanged, and the preparation method was performed according to the method of example 3.
Comparative example 5
Compared with example 3, the prepared intermediate I and commercial lecithin are used as penetration enhancers, wherein the weight ratio of the intermediate I to the lecithin is 1: 1, the remaining composition was unchanged and the preparation was carried out according to the method of example 3.
Comparative example 6
Compared with the example 3, the prepared intermediate II and the commercial hyaluronic acid are used as the transdermal enhancer, wherein the weight ratio of the intermediate II to the hyaluronic acid is 1: 1, the remaining composition was unchanged and the preparation was carried out according to the method of example 3.
Comparative example 7
Compared with the example 3, the commercially available hyaluronic acid and lecithin are used as the transdermal enhancer, wherein the weight ratio of the hyaluronic acid to the lecithin is 1: 1, the remaining composition was unchanged and the preparation was carried out according to the method of example 3.
Comparative example 8
Compared with example 3, the chamomile extract is not included, and other conditions are unchanged, specifically:
a skin caring cosmetic comprises folium Vaccinii Vitis-idaeae extract;
the preparation method of the bearberry leaf extract comprises the following steps: washing 23 parts by weight of bearberry leaves, crushing, soaking in 60% ethanol solution for extraction, filtering the extract, washing, combining the filtrates, treating the filtrate with saturated neutral lead acetate aqueous solution, precipitating the organic acids, phenolic acids, tannins and flavonoids in the filtrate to generate insoluble lead salt precipitate, filtering out the precipitate, precipitating the filtrate with alkaline lead aqueous solution, filtering out the precipitate, suspending the precipitate in distilled water, introducing hydrogen sulfide gas into the suspension to generate colloidal lead sulfide precipitate, performing suction filtration, washing the filtrate with water, combining the filtrates, and concentrating the filtrate under reduced pressure to obtain the compound.
A skin-beautifying cosmetic is prepared from the following raw materials in parts by weight: 14 parts of bearberry leaf extract, 6 parts of transdermal enhancer, 20 parts of 1, 3-propylene glycol, 38 parts of glycerol, 4 parts of ascorbic acid, 4 parts of xanthan gum, 3 parts of benzoic acid, 5 parts of emulsifier, 2 parts of sun-screening agent and 480 parts of solvent.
Wherein, the preparation process of the penetration enhancer is as follows:
t1, adding 12 parts by weight of phosphoric acid into 16 parts by weight of glycerol, adding 6 parts by weight of petroleum ether into the glycerol, starting a stirring device, raising the temperature to 70 ℃, reacting for 5 hours, and heating and refluxing to obtain an intermediate I;
t2, adding 16 parts by weight of sodium glutamate into 22 parts by weight of glycerol, uniformly mixing, adding 6 parts by weight of zeolite and 4 parts by weight of sodium carbonate, raising the temperature to 135 ℃, stopping heating and stirring after 5 hours of reaction, standing for layering, separating a lower water layer, dropwise adding 14 parts by weight of hydrochloric acid into the mixture under a stirring state, filtering after 4 hours of reaction, evaporating and drying the filtrate, dropwise adding an ethanol solution into the filtrate, and crystallizing, filtering and drying to obtain an intermediate II;
and T3, mixing 16 parts by weight of the intermediate I and 16 parts by weight of the intermediate II, adding 7 parts by weight of copper sulfate and 15 parts by weight of cyclohexane, starting stirring, raising the temperature to 110 ℃, reacting for 6 hours, filtering, and heating and refluxing the filtrate to obtain the copper-based catalyst.
Wherein the emulsifier is lanolin and beeswax according to a weight ratio of 1: 1, the sun-screening agent is phenyl benzimidazole sulfonic acid triethanolamine, and the solvent is deionized water.
A skin-beautifying cosmetic comprises the following steps:
s1, mixing 20 parts by weight of 1, 3-propylene glycol, 38 parts by weight of glycerol, 4 parts by weight of ascorbic acid, 2 parts by weight of sun-screening agent and 480 parts by weight of solvent according to the parts by weight of the raw materials, heating to 45 ℃, and uniformly stirring;
s2, adding 14 parts by weight of bearberry leaf extract into the solution obtained in the step S1 after mixing uniformly, sequentially adding 6 parts by weight of penetration enhancer, 3 parts by weight of benzoic acid and 5 parts by weight of emulsifier after mixing uniformly, adding 4 parts by weight of xanthan gum after mixing uniformly to adjust the viscosity, and mixing uniformly to obtain the product.
Comparative example 9
Compared with the example 3, the method does not comprise the bearberry leaf extract, and other conditions are unchanged, specifically:
a skin cosmetic comprises Chamomile extract;
the preparation method of the chamomile extract comprises the following steps: crushing and grinding 18 parts by weight of cleaned and dried chamomile, sieving with a 150-mesh sieve, soaking the sieved product in a 60% ethanol solution, heating and refluxing for 3 hours at 55 ℃, repeating twice, collecting and combining extracting solutions, centrifuging and performing suction filtration to obtain a chamomile crude extract, dissolving the chamomile crude extract in deionized water, and extracting with n-butyl alcohol, wherein the method specifically comprises the following steps: adding 180ml of n-butanol into the crude extract of chamomile, performing shaking extraction, separating n-butanol extract from water phase extract to obtain n-butanol phase, and vacuum drying.
A skin-beautifying cosmetic is prepared from the following raw materials in parts by weight: 14 parts of chamomile extract, 6 parts of transdermal enhancer, 20 parts of 1, 3-propylene glycol, 38 parts of glycerol, 4 parts of ascorbic acid, 4 parts of xanthan gum, 3 parts of benzoic acid, 5 parts of emulsifier, 2 parts of sun-screening agent and 480 parts of solvent.
Wherein, the preparation process of the penetration enhancer is as follows:
t1, adding 12 parts by weight of phosphoric acid into 16 parts by weight of glycerol, adding 6 parts by weight of petroleum ether into the glycerol, starting a stirring device, raising the temperature to 70 ℃, reacting for 5 hours, and heating and refluxing to obtain an intermediate I;
t2, adding 16 parts by weight of sodium glutamate into 22 parts by weight of glycerol, uniformly mixing, adding 6 parts by weight of zeolite and 4 parts by weight of sodium carbonate, raising the temperature to 135 ℃, reacting for 5 hours, stopping heating and stirring, standing for layering, separating a lower water layer, dropwise adding 14 parts by weight of hydrochloric acid into the mixture under a stirring state, reacting for 4 hours, filtering, evaporating and drying the filtrate, dropwise adding an ethanol solution into the filtrate, crystallizing, filtering and drying to obtain an intermediate II;
t3, mixing 16 parts by weight of the intermediate I and 16 parts by weight of the intermediate II, adding 7 parts by weight of copper sulfate and 15 parts by weight of cyclohexane, starting stirring, raising the temperature to 110 ℃, reacting for 6 hours, filtering, and heating and refluxing the filtrate to obtain the copper-aluminum-copper-manganese-zinc-manganese composite material.
Wherein the emulsifier is lanolin and beeswax according to a weight ratio of 1: 1, the sun-screening agent is phenyl benzimidazole sulfonic acid triethanolamine, and the solvent is deionized water.
A skin makeup cosmetic comprising the steps of:
s1, mixing 20 parts by weight of 1, 3-propylene glycol, 38 parts by weight of glycerol, 4 parts by weight of ascorbic acid, 2 parts by weight of sun-screening agent and 480 parts by weight of solvent according to the parts by weight of the raw materials, heating to 45 ℃, and uniformly stirring;
s2, mixing 14 parts by weight of chamomile extract, adding the mixture into the solution obtained in the step S1, uniformly mixing, sequentially adding 6 parts by weight of penetration enhancer, 3 parts by weight of benzoic acid and 5 parts by weight of emulsifier, uniformly mixing, adding 4 parts by weight of xanthan gum to adjust the viscosity, and uniformly mixing to obtain the chamomile.
And (4) relevant testing:
cosmetic moisturizing Effect test
And (3) testing conditions are as follows: the test environment temperature is 20-22 deg.C and the environment humidity is 40% -60%.
And (3) testing:
(1) multiple 3cm by 3cm test areas were marked on the inside of the subject's forearm, leaving the cosmetic application and blank control areas randomly distributed.
(2) Measurements were made using a skin moisture meter in the painted and blank areas before using the samples, and initial measurements were recorded.
(3) Immediately apply 6mg of cosmetic in one pass with a pipette over the application area, wearing latex gloves to apply evenly. The skin moisture content was measured for all areas at set times, 3 times per area, with test times not exceeding 24 hours.
(4) And after the measurement is finished, counting the measured values of all the test areas, and judging the moisturizing effect of the cosmetics.
Randomly selecting 25 volunteers 18-30 years old for trial, not applying any product 2-3 days before the test, not contacting water 1-2h before the test, wiping the test part of the volunteer clean by using a dry paper towel before the test, measuring the moisturizing effect of the cosmetics prepared in example 3 and comparative examples 5-6, and setting a control group to measure the self moisturizing capability of the skin, wherein the experimental result is shown in figure 1.
As can be seen from fig. 1, the moisture content of the skin gradually decreases with time, wherein the initial moisturizing effect of the cosmetic prepared in example 3 is the best, the moisture content of the skin after application is about 49.5, and the moisture content of the skin per se is about 32.0 according to the change of the control group data, and the moisture content of the skin starts to be stable at 14h after the cosmetic is applied, i.e. the prepared cosmetic can maintain the moisturizing effect for about 14h, can supplement moisture to the horny layer of the skin and can prevent rapid volatilization of the moisture; according to the data of comparative examples 5 to 7, it was found that the moisturizing effect of the cosmetics prepared using the intermediate I and lecithin and the intermediate II and hyaluronic acid as the permeation enhancer was superior to that of the cosmetics prepared using hyaluronic acid and lecithin as the permeation enhancer; comparing the data of example 3 and comparative examples 5 to 6, it was found that the moisturizing effect of the skin of the cosmetics prepared using the penetration enhancer prepared in example 3 was superior to the moisturizing effect of the cosmetics prepared using the intermediate I and lecithin and the intermediate II and hyaluronic acid as the penetration enhancers.
In vitro transdermal absorption experiment
In vitro transdermal performance a vertical Franz diffusion cell method was used for in vitro transdermal drug testing of rat skin. SD rat abdominal skin was fixed between a diffusion cell receiving chamber and a feeding chamber of r 1cm, and 1g of a sample was placed in the feeding chamber, and diffused at 37 ℃ under stirring at 300r/min using 2% SDS-20% ethanol-physiological saline as a receiving solution. 0.5mL of receiving solution is taken at 2h, 4h, 6h, 8h, 10h, 12h and 24h, and the equal amount of constant-temperature blank receiving solution is immediately supplemented. HPLC analysis, calculate the cumulative permeation of the drug over time. After 24h, the skin is taken down, ultrapure water is used for washing off residual liquid of the sample, the sample is cut into pieces and is transferred into a tissue homogenizer to be fully ground into homogenate, a proper amount of ethanol is added to be transferred into a centrifuge tube, the mixture is subjected to ultrasonic treatment for 5min and 5000r/min and is centrifuged for 10min, supernatant liquid is taken for HPLC analysis, and the retention amount of the sample in the skin is calculated, and the result is shown in Table 1, wherein the sample is the cosmetic sample prepared in example 3 and comparative examples 1-7.
TABLE 1
As can be seen from the data in Table 1, the penetration enhancer prepared in example 3 has good skin permeability and skin retention ability as compared with those of comparative examples 1 to 7; the transdermal penetration enhancer prepared in example 3 had a cumulative skin penetration amount of about 9.29 times and a cumulative skin retention amount of about 7.10 times as compared with those of comparative example 3, and it was found from the data of comparative examples 5 to 7 that the transdermal absorbability of the cosmetics prepared using intermediate I and lecithin and intermediate II and hyaluronic acid as the transdermal penetration enhancer was better than that of the cosmetics prepared using hyaluronic acid and lecithin as the transdermal penetration enhancer; the above shows that the penetration enhancer prepared in example 3 is effective in promoting its retention in the skin at a high concentration.
Evaluation on trial
The tester: randomly selecting 60 volunteers of 18-30 years old for trial.
And (3) testing environment: the temperature is 20 +/-2 ℃, and the humidity is 45% +/-5%.
The test method comprises the following steps: before formal testing, the tested part is cleaned by using the designated facial cleanser, a room meeting the standard is stood still for at least 30min, the appearance and the fragrance of the cosmetics prepared in the examples 1-3 and the comparative examples 1-3 are scored in the process of sitting still, and after the samples of the examples and the comparative examples are smeared, the scores of the corresponding items are recorded: the total points of smoothness (1-10 points), moistening degree (1-10 points), lightness and thinness (1-10 points), gloss (1-10 points), skin comfort (1-10 points), freshness (1-10 points) and fragrance (1-10 points) were calculated and averaged, and the results are shown in table 2.
TABLE 2
Test group | Average score |
Example 1 | 60.0 |
Example 2 | 60.1 |
Example 3 | 64.5 |
Comparative example 1 | 40.9 |
Comparative example 2 | 42.8 |
Comparative example 3 | 45.6 |
Comparative example 4 | 44.3 |
Comparative example 5 | 42.0 |
Comparative example 6 | 46.2 |
Comparative example 7 | 48.3 |
Comparative example 8 | 54.5 |
Comparative example 9 | 55.7 |
As can be seen from the data of table 2, the cosmetics prepared in examples 1 to 3 were evaluated higher than those prepared in comparative examples 1 to 9, of which the cosmetic prepared in example 3 was evaluated the highest.
Compared with the prior art, the chamomile extract is prepared by soaking crushed chamomile in an ethanol solution, heating and refluxing, and extracting by using a method of extracting n-butyl alcohol; in the process of preparing the bearberry leaf extract, the bearberry leaf extract is soaked in an ethanol solution, after extraction, saturated neutral lead acetate aqueous solution and alkaline lead aqueous solution are used for precipitation, hydrogen sulfide gas is introduced into suspension to generate colloidal lead sulfide precipitate, and the filtrate is subjected to suction filtration and reduced pressure concentration to obtain the bearberry leaf extract. Chamomile, a Chinese herbal medicine of chamomile of the family Compositae, also called chamomile, is widely distributed in countries in northern Europe, mainly contains flavones, phenolic acids, coumarins, polysaccharides, terpenoids and the like, has the efficacies of resisting allergy, diminishing inflammation, resisting oxidation, resisting virus, inhibiting bacteria, relieving spasm, treating ulcer, clearing heat, resisting vascular proliferation and the like, and can play a good role in repairing sensitive skin, reducing fine red blood streak, reducing redness and adjusting uneven skin color; the arbutin leaf contains rich arbutin, can rapidly permeate into skin, can effectively inhibit the activity of tyrosinase in the skin and block the formation of melanin while not influencing the cell proliferation concentration, accelerates the decomposition and excretion of the melanin by directly combining the arbutin leaf with the tyrosinase, thereby reducing the skin pigmentation, removing color spots and freckles, generating no toxic or side effects such as toxicity, irritation, sensitization and the like on the melanocyte, and simultaneously has the functions of sterilization and inflammation diminishing, and can effectively brighten the skin color.
The horny layer is the outermost layer of the epidermis and consists of 4-8 dead flat lamellar anucleated cells, and the horny cells and intercellular lipid form a 'brick wall structure', wherein the 'brick wall' represents the horny cells and consists of keratin, non-fibrin and a small amount of lipid; "mortar" refers to the lipid in the interstitial spaces of keratinocytes. The main components of lipid are ceramide, cholesterol and saturated fatty acid to form a lipid bilayer structure, the stratum corneum can protect the skin, prevent in-vivo tissue fluid from exosmosis, limit substances such as water, lipid or cosmetic components from passing through, keep the skin soft and moist, in transdermal absorption, nonpolar substances can easily cross a cell barrier through a part rich in lipid, namely diffuse through intercellular channels. One end of the transdermal enhancer prepared by the invention contains phosphate, the stratum corneum is formed by horny cells and intercellular lipid, the transdermal enhancer containing phosphate can be easily diffused through lipid bilayers in intercellular spaces, when the molecules are inserted into a lipid bilayer hydrophobic structure of stratum corneum lipid, due to the existence of a long-chain structure, the bilayers are twisted to form a fine and easily permeable flowing channel, the ordered arrangement of stratum corneum lipid structures is effectively influenced, the diffusion resistance is reduced, the diffusion and absorption of related components are promoted, and the other end of the transdermal enhancer has strong hygroscopicity, can absorb moisture from the air and has high moisture retention capacity, namely, due to the existence of the structure of the transdermal enhancer, the transdermal enhancer has high humidity retention capacity while promoting the diffusion and absorption of the related components.
It should be noted that, in this document, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present application have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the application, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. A skin cosmetic is characterized by comprising chamomile extract and bearberry leaf extract;
the preparation method of the chamomile extract comprises the following steps: pulverizing cleaned and dried flos Matricariae Chamomillae, grinding, sieving, soaking in ethanol solution, heating under reflux, collecting extractive solution, centrifuging, vacuum filtering, dissolving in deionized water, and extracting with n-butanol;
the preparation method of the bearberry leaf extract comprises the following steps: cleaning leaves of bearberry, pulverizing, soaking in ethanol solution for extraction, filtering the extractive solution, washing, mixing filtrates, treating the filtrate with saturated neutral lead acetate aqueous solution, filtering to obtain precipitate, precipitating the filtrate with alkaline lead aqueous solution, filtering to remove precipitate, suspending in distilled water, introducing hydrogen sulfide gas into the suspension to generate precipitate, vacuum filtering, washing the filtrate with water, mixing filtrates, and concentrating the filtrate under reduced pressure.
2. A skin cosmetic according to claim 1, wherein the chamomile extract is prepared by a process in which the conditions of heat reflux are as follows: reflux at 55 ℃ for 3h, repeat twice.
3. The skin-beautifying cosmetic according to claim 1, which is prepared from the following raw materials in parts by weight: 12-16 parts of chamomile extract, 12-16 parts of bearberry leaf extract, 5-8 parts of transdermal enhancer, 18-22 parts of 1, 3-propylene glycol, 35-44 parts of glycerol, 3-5 parts of ascorbic acid, 3-5 parts of xanthan gum, 2-4 parts of benzoic acid, 4-6 parts of emulsifier, 1-4 parts of sun-screening agent and 500 parts of solvent 450-.
4. The skin makeup cosmetic according to claim 3, wherein said penetration enhancer is prepared by:
t1, adding phosphoric acid into glycerol, adding petroleum ether into the glycerol, starting a stirring device, raising the temperature, reacting for 4-6h, and heating and refluxing to obtain an intermediate I;
t2, adding sodium glutamate into glycerol, adding zeolite and sodium carbonate after uniformly mixing, raising the temperature, stopping heating and stirring after reacting for 4-6h, standing for layering, separating out a lower water layer, dropwise adding hydrochloric acid into the lower water layer under a stirring state, filtering after reacting for 2-4h, dropwise adding an ethanol solution into the filtrate after evaporating and drying, and crystallizing, filtering and drying to obtain an intermediate II;
and T3, mixing the intermediate I and the intermediate II, adding copper sulfate and cyclohexane, stirring, raising the temperature, filtering after reaction, and heating and refluxing the filtrate to obtain the copper-aluminum-copper alloy.
5. The skin-beautifying cosmetic according to claim 3, characterized in that the emulsifier is one or more of lecithin, lanolin alcohol, beeswax, polyoxyethylene lanolin alcohol, and glyceryl monostearate.
6. The skin-beautifying cosmetic according to claim 3, wherein the sunscreen agent is one or a mixture of more of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl salicylate, ethylhexyl triazone, phenylbenzimidazole sulfonic acid, methylene bis-benzotriazolyl tetramethylbutylphenol, phenylbenzimidazole sulfonic acid triethanolamine, and diethylamino hydroxybenzoyl hexyl benzoate.
7. The skin cosmetic of claim 3, wherein the solvent is deionized or distilled water.
8. The skin cosmetic according to claim 4, wherein in the step T1, the temperature is raised to 65-75 ℃; in the step T2, the temperature is raised to 130-150 ℃; the temperature is raised to 110-120 ℃ in step T3.
9. A skin cosmetic according to any one of claims 1 to 8, comprising the steps of:
s1, mixing 1, 3-propylene glycol, glycerol, ascorbic acid, a sun-screening agent and a solvent according to the weight parts of the raw materials, heating to 40-50 ℃, and uniformly stirring;
s2, mixing the chamomile extract and the bearberry leaf extract, adding the mixture into the solution obtained in the step S1, adding the penetration enhancer, the benzoic acid and the emulsifier in sequence after uniform mixing, adding the xanthan gum after uniform mixing to adjust the viscosity, and mixing uniformly to obtain the product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210391975.6A CN114788799A (en) | 2022-04-14 | 2022-04-14 | Skin-beautifying cosmetic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210391975.6A CN114788799A (en) | 2022-04-14 | 2022-04-14 | Skin-beautifying cosmetic |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114788799A true CN114788799A (en) | 2022-07-26 |
Family
ID=82462125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210391975.6A Pending CN114788799A (en) | 2022-04-14 | 2022-04-14 | Skin-beautifying cosmetic |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114788799A (en) |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5358715A (en) * | 1992-09-02 | 1994-10-25 | Cygnus Therapeutic Systems | Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters |
CN101985459A (en) * | 2010-11-18 | 2011-03-16 | 桂林安和药业有限公司 | Process for extracting greater than or equal to 98% of ursolic acid from loquat leaf |
CN102070585A (en) * | 2009-11-23 | 2011-05-25 | 湖州来色生物基因工程有限公司 | New process for extracting barbaloin |
US20110244022A1 (en) * | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
CN102920786A (en) * | 2012-11-16 | 2013-02-13 | 武汉代代木生物科技有限公司 | Method for preparing preparation capable of protecting liver, resisting tumors, reducing blood lipid and regulating immunity |
CN104414891A (en) * | 2013-08-22 | 2015-03-18 | 李霞 | Plant skin care cream |
CN104586683A (en) * | 2014-12-22 | 2015-05-06 | 广东高鑫科技股份有限公司 | Preparation method for natural animal and plant extract whitening and skin care cream and product of natural animal and plant extract whitening and skin care cream |
CN109316422A (en) * | 2018-12-03 | 2019-02-12 | 甘肃泛植制药有限公司 | A kind of vegetalitas anti-sensitizer stoste and its preparation method and application |
CN113274323A (en) * | 2021-05-18 | 2021-08-20 | 滁州雅丽洁日用制品有限公司 | A cosmetic composition containing plant extract |
CN113398053A (en) * | 2021-07-27 | 2021-09-17 | 江苏巴帝恩生物科技有限公司 | Preparation method and application of skin-moistening composition with allergy-relieving and moisture-preserving effects |
-
2022
- 2022-04-14 CN CN202210391975.6A patent/CN114788799A/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5358715A (en) * | 1992-09-02 | 1994-10-25 | Cygnus Therapeutic Systems | Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters |
CN102070585A (en) * | 2009-11-23 | 2011-05-25 | 湖州来色生物基因工程有限公司 | New process for extracting barbaloin |
US20110244022A1 (en) * | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
CN101985459A (en) * | 2010-11-18 | 2011-03-16 | 桂林安和药业有限公司 | Process for extracting greater than or equal to 98% of ursolic acid from loquat leaf |
CN102920786A (en) * | 2012-11-16 | 2013-02-13 | 武汉代代木生物科技有限公司 | Method for preparing preparation capable of protecting liver, resisting tumors, reducing blood lipid and regulating immunity |
CN104414891A (en) * | 2013-08-22 | 2015-03-18 | 李霞 | Plant skin care cream |
CN104586683A (en) * | 2014-12-22 | 2015-05-06 | 广东高鑫科技股份有限公司 | Preparation method for natural animal and plant extract whitening and skin care cream and product of natural animal and plant extract whitening and skin care cream |
CN109316422A (en) * | 2018-12-03 | 2019-02-12 | 甘肃泛植制药有限公司 | A kind of vegetalitas anti-sensitizer stoste and its preparation method and application |
CN113274323A (en) * | 2021-05-18 | 2021-08-20 | 滁州雅丽洁日用制品有限公司 | A cosmetic composition containing plant extract |
CN113398053A (en) * | 2021-07-27 | 2021-09-17 | 江苏巴帝恩生物科技有限公司 | Preparation method and application of skin-moistening composition with allergy-relieving and moisture-preserving effects |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TWI477291B (en) | Method for extracting using glacial water and the extract thereof, and cosmetic composition comprising nanoemulsion particles having the extract encapsulated or the glacial water | |
JP4563521B2 (en) | Collagen production promoter and topical skin preparation | |
KR100638137B1 (en) | Cosmetic composition containing the Potentilla fragariodes var? major extracts | |
KR101746639B1 (en) | Composition with skin lightening and moisturizing effects containing bee venom extracts | |
CN104207997A (en) | Deep revitalizing facial mask containing morinda citrifolia stock extract liquid and preparation method thereof | |
CN109106677B (en) | Composition with whitening function and application thereof | |
CN110090191B (en) | After-sun repair composition and cosmetic thereof | |
KR102227355B1 (en) | Complex cosmetic composition for non-irritating weak acid exfoliation and epithelial cell nutrition | |
KR20060089898A (en) | Composition of skin external application containing rose extract and epigallocatechin gallate(egcg) | |
KR101595530B1 (en) | Liposome composition having excellent effect of skin wrinkle improvement and skin whitening for accelerating percutaneous absorption | |
KR100881143B1 (en) | Composition of skin external application containing green tea flower extract | |
JP3370289B2 (en) | Cosmetic and method for producing cosmetic | |
KR101862039B1 (en) | A cosmetic composition containing spicule powder and natural complex extract stabilized in nanoliposome | |
JP2000169329A (en) | Cosmetic composition | |
CN111973487A (en) | Ceramide moisturizing essence and preparation method thereof | |
KR100371504B1 (en) | Cosmetics composition comprising extract powder with vitis vinifera l.fermented solution and having whitening and anti-wrinkle effect | |
KR20130102712A (en) | Anti-heat aging effect of fermented limonia acidissima extract and its cosmetic usage to improve skin problems | |
KR20050117958A (en) | Topical nano liposome formulation including extracted purified herbal mixture and whitening cosmetics using this formulation | |
KR101154772B1 (en) | Cosmetic composition containing the zizyphus jujuba fruit extract and walnut extract for moisturizing effect on the skin | |
KR102056620B1 (en) | External composition for skin containing Cannabis sativa extract | |
KR101232720B1 (en) | External preparation composition for removal the dead skin cell | |
CN114788799A (en) | Skin-beautifying cosmetic | |
KR101068320B1 (en) | Forest relaxing skin care composition with high moisturizing and skin purifying effects | |
KR102333132B1 (en) | Cosmetic Composition containing Frangipani Oil or Fermented Frangipani Oil | |
JP2000256175A (en) | Cosmetic composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220726 |
|
RJ01 | Rejection of invention patent application after publication |