CN114786660A - 使用mtorc1调节剂的治疗方法 - Google Patents

使用mtorc1调节剂的治疗方法 Download PDF

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Publication number
CN114786660A
CN114786660A CN202080083322.0A CN202080083322A CN114786660A CN 114786660 A CN114786660 A CN 114786660A CN 202080083322 A CN202080083322 A CN 202080083322A CN 114786660 A CN114786660 A CN 114786660A
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compound
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study
patient
day
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Chinese (zh)
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S·勒文特
S·D·塔尔古姆
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Navitor Pharmaceuticals Inc
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Navitor Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080083322.0A 2019-11-01 2020-11-02 使用mtorc1调节剂的治疗方法 Pending CN114786660A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962929449P 2019-11-01 2019-11-01
US62/929,449 2019-11-01
PCT/US2020/058475 WO2021087432A1 (en) 2019-11-01 2020-11-02 Methods of treatment using an mtorc1 modulator

Publications (1)

Publication Number Publication Date
CN114786660A true CN114786660A (zh) 2022-07-22

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CN202080083322.0A Pending CN114786660A (zh) 2019-11-01 2020-11-02 使用mtorc1调节剂的治疗方法

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US (2) US11723890B2 (https=)
EP (1) EP4051259A4 (https=)
JP (2) JP2022554276A (https=)
CN (1) CN114786660A (https=)
AU (1) AU2020376950A1 (https=)
BR (1) BR112022008287A2 (https=)
CA (1) CA3156436A1 (https=)
IL (1) IL292612A (https=)
MX (1) MX2022005215A (https=)
TW (1) TWI870497B (https=)
WO (1) WO2021087432A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016342027B2 (en) 2015-10-23 2021-05-13 Navitor Pharmaceuticals, Inc. Modulators of Sestrin-GATOR2 interaction and uses thereof
PL3615019T3 (pl) 2017-04-26 2026-01-19 Navitor Pharmaceuticals, Inc. Modulator interakcji sestryna-gator2 do zastosowania w leczeniu depresji opornej na leczenie
EP3870158A4 (en) 2018-10-24 2022-08-10 Navitor Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
US11723890B2 (en) 2019-11-01 2023-08-15 Navitor Pharmaceuticals, Inc. Methods of treatment using an mTORC1 modulator
AU2023374029A1 (en) * 2022-11-01 2025-05-08 Navitor Pharmaceuticals, Inc. MODULATORS OF mTORC1 ACTIVITY AND USES THEREOF
WO2026085331A1 (en) 2024-10-16 2026-04-23 Navitor Pharmaceuticals, Inc. Mefluleucin for use in the treatment of suicidal ideations associated with depression

Citations (1)

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US11723890B2 (en) 2023-08-15
EP4051259A1 (en) 2022-09-07
CA3156436A1 (en) 2021-05-06
US12465583B2 (en) 2025-11-11
AU2020376950A1 (en) 2022-06-09
IL292612A (en) 2022-07-01
TW202131910A (zh) 2021-09-01
MX2022005215A (es) 2022-06-08
EP4051259A4 (en) 2023-11-22
JP2022554276A (ja) 2022-12-28
US20240041811A1 (en) 2024-02-08
BR112022008287A2 (pt) 2022-07-26
TWI870497B (zh) 2025-01-21
US20210169835A1 (en) 2021-06-10
WO2021087432A1 (en) 2021-05-06
JP2025129244A (ja) 2025-09-04

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