CN114748600A - 一种用于治疗维持阶段冠心病的中药组合物及其制备方法 - Google Patents
一种用于治疗维持阶段冠心病的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及中药技术领域,具体地说,涉及一种用于治疗维持阶段冠心病的中药组合物及其制备方法,采用以下原料配方制成:黄芪、阿胶、麦冬、红参、茯苓、熟地、烫龟甲、桂枝、柴胡、黄芩、川芎、煅紫石英、淫羊藿、金银花、丹参、牡丹皮、牛膝、郁金、炒枳实、全瓜蒌、枸杞、黑附子、炮姜、桃仁、红花、当归、大枣、生姜。本发明通过选取特定中药成分并限定具体的配比,经煎煮、发酵后制得的药剂用于维持阶段冠心病的治疗,能够显著降低维持阶段冠心病的复发,相对于现有治疗冠心病药剂的治疗效果更为显著,稳定性高、复发率低、出现并发症的概率小。
Description
技术领域
本发明涉及中药技术领域,具体地说,涉及一种用于治疗维持阶段冠心病的中药组合物及其制备方法。
背景技术
冠心病一般指冠状动脉粥样硬化性心脏病,是冠状动脉血管发生动脉粥样硬化病变而引起血管腔狭窄或阻塞,造成心肌缺血、缺氧或坏死而导致的心脏病。世界卫生组织将冠心病分为5大类:无症状心肌缺血(隐匿性冠心病)、心绞痛、心肌梗死、缺血性心力衰竭(缺血性心脏病)和猝死5种临床类型。临床中,常常分为稳定性冠心病和急性冠状动脉综合征。冠心病的病因复杂,相关因素有:饮食不节、风寒内侵、机体气虚、寒湿引邪入里、气滞血瘀、日久化热、气血亏虚等等。
冠心病治疗的最终目标是防止心脑血管病的发生,保护心脑血管,尽可能减少心脑血管的损伤。冠心病的治疗可分为两个阶段:急性治疗阶段和治疗维持阶段。急性治疗阶段的目的是使急性期的症状尽快缓解(2-5个月内),尽可能减少心脑血管病的实质损伤。治疗维持阶段的目的是使冠心病处于非治疗状态,防止疾病复发和心脑肾功能进展性损伤`,同时尽量减少西药药物治疗的毒副作用。
迄今为止,国际上对冠心病的维持治疗方案未达成共识。广东省中医药大学冠心病研究中心教授指出:“国内在重证工心病治疗中普遍存在着对急性治疗和维持治疗的意义及其合理应用的原则认识不足,表现在急性治疗取得效果后不重视维持治疗,甚或中断治疗,导致冠心病病情迅速复发。虽然再次应用急性治疗又不可能致使病情缓解,但已加重了心脑肾脏器的损害,加速冠心病引起心梗和脑卒中的复发。”可见,冠心病维持阶段的治疗是保护心脑肾脏器功能的关键环节,但目前该维持阶段的治疗尚未引起重视。
在对冠心病完成急性治疗缓解后,进一步降低血脂,胆固醇,血压,维持冠心病病情稳定不复发是维持治疗阶段的治疗目的。现有技术中,最普遍采用的冠心病维持治疗阶段的药物主要是西药,如:利尿剂、扩张血管制剂、钙调节剂等。上述几种西药抑制剂虽然再一定程度上能够降低复发风险,但由于抑制剂自身对机体的危害性大,其防复发效果和降低并发症的效果依然有待加以提高。
发明内容
本发明的目的在于,提供一种用于治疗维持阶段冠心病的中药组合物及其制备方法,解决上述的技术问题。
为实现上述目的,本发明所采用的技术方案是:
一种用于治疗维持阶段冠心病的中药组合物,采用以下质量份数的原料配方制成:黄芪15-95份、阿胶5-50份、麦冬15-65份、红参15-55份、茯苓15-60份、熟地30-90份、烫龟甲15-45份、桂枝30-60份、柴胡20-60份、黄芩10-45份、川芎30-60份、煅紫石英10-30份、淫羊藿30-65份、金银花10-30份、丹参30-75份、牡丹皮15-30份、牛膝10-65份、郁金15-30份、炒枳实30-50份、全瓜蒌15-65份、枸杞15-65份、黑附子10-30份、炮姜10-20份、桃仁10-30份、红花10-30份、当归10-45份、大枣30-75份、生姜15-50份。
本发明所述用于治疗维持阶段冠心病的中药组合物的制备方法,包括以下步骤:
1、将配方中的中药原料炮制粉碎后,过50目筛,室温下用水浸泡1-2小时;浸泡好的中药材,先用武火煮沸后,再用文火煎煮40-60min;
2、把煎煮中药原料制得的药液、药渣一起放入发酵罐内进行发酵,发酵罐内保持温度35-37℃;
3、发酵两周后,滤出发酵液;低温干燥成粉剂,灭菌消毒后装瓶,即制得治疗冠心病的中药制剂。
本发明中各种原料的功效如下:
黄芪:补气升阳,益卫固表。
阿胶:润燥滋阴,补血,止血,调经安胎。
麦冬:养阴生津,润肠通便,润肺止咳。
红参:生津补气,补脾益肺,安神益智。
茯苓:利水祛湿。
熟地:滋阴补血。
烫龟甲:养阴通络。
桂枝:解表通阳。
柴胡:解表清热。
黄芩:解表清肺。
川芎:活血行气,祛风止痛。
煅紫石英:治心悸、怔忡、惊痫、肺寒咳逆上气、女子宫寒不孕。
淫羊藿:补肾壮阳、祛风除湿。
金银花:清热解毒、消炎去肿。
丹参:活血祛瘀、通经止痛、清心除烦、凉血消痈。
牡丹皮:疏肝解郁。
牛膝:逐瘀通经、补肝肾、强筋骨、利尿通淋、引血下行。
郁金:行气解郁。
炒枳实:破气消积、化痰散痞。
全瓜蒌:清热化痰、宽胸散结。
枸杞:滋肾、润肺、补肝、明目。
黑附子:回阳救逆、补火助阳、散寒止痛。
炮姜:温中散寒、温经止血。
桃仁:活血祛瘀、润肠通便、止咳平喘。
红花:活血通经、散瘀止痛。
当归:补血活血、调经止痛、润肠通便。
大枣:补脾和胃、益气生津、调营卫、解药毒。
生姜:解表散寒、温中止呕、化痰止咳。
有益效果:长期跟踪治疗效果显示,本发明通过选取特定中药成分并限定具体的配比,经煎煮、发酵后制得的药剂用于维持阶段冠心病的治疗,能够显著降低维持阶段冠心病的复发,相对于现有治疗冠心病药剂的治疗效果更为显著,稳定性高、复发率低、出现并发症的概率小。
具体实施方式
下面结合具体实施例对本发明做进一步的描述。
实施例1:
本实施例所述用于治疗维持阶段冠心病的中药组合物,采用以下质量份数的原料配方制成:黄芪15份、阿胶5份、麦冬15份、红参15份、茯苓15份、熟地30份、烫龟甲15份、桂枝30份、柴胡20份、黄芩10份、川芎30份、煅紫石英10份、淫羊藿30份、金银花10份、丹参30份、牡丹皮15份、牛膝10份、郁金15份、炒枳实30份、全瓜蒌15份、枸杞15份、黑附子10份、炮姜10、桃仁10份、红花10份、当归10份、大枣30份、生姜15份。
本发明所述用于治疗维持阶段冠心病的中药组合物的制备方法,包括以下步骤:
1、将配方中的中药原料炮制粉碎后,过50目筛,室温下用水浸泡1小时;浸泡好的中药材,先用武火煮沸后,再用文火煎煮40min;
2、把煎煮中药原料制得的药液、药渣一起放入发酵罐内进行发酵,发酵罐内保持温度35℃;
3、发酵两周后,滤出发酵液;低温干燥成粉剂,灭菌消毒后装瓶,即制得治疗冠心病的中药制剂。
实施例2:
本实施例所述用于治疗维持阶段冠心病的中药组合物,采用以下质量份数的原料配方制成:黄芪95份、阿胶50份、麦冬65份、红参55份、茯苓60份、熟地90份、烫龟甲45份、桂枝60份、柴胡60份、黄芩45份、川芎60份、煅紫石英30份、淫羊藿65份、金银花30份、丹参75份、牡丹皮30份、牛膝65份、郁金30份、炒枳实50份、全瓜蒌65份、枸杞65份、黑附子30份、炮姜20份、桃仁30份、红花30份、当归45份、大枣75份、生姜50份。
本发明所述用于治疗维持阶段冠心病中药组合物的制备方法,包括以下步骤:
1、将配方中的中药原料炮制粉碎后,过50目筛,室温下用水浸泡2小时;浸泡好的中药材,先用武火煮沸后,再用文火煎煮60min;
2、把煎煮中药原料制得的药液、药渣一起放入发酵罐内进行发酵,发酵罐内保持温度37℃;
3、发酵两周后,滤出发酵液;低温干燥成粉剂,灭菌消毒后装瓶,即制得治疗冠心病的中药制剂。
实施例3:
本实施例所述用于治疗维持阶段冠心病的中药组合物,采用以下质量份数的原料配方制成:黄芪55份、阿胶35份、麦冬50份、红参40份、茯苓35份、熟地60份、烫龟甲30份、桂枝40份、柴胡40份、黄芩25份、川芎40份、煅紫石英20份、淫羊藿35份、金银花20份、丹参55份、牡丹皮25份、牛膝45份、郁金20份、炒枳实40份、全瓜蒌35份、枸杞45份、黑附子20份、炮姜15份、桃仁20份、红花20份、当归25份、大枣45份、生姜30份。
本发明所述用于治疗维持阶段冠心病中药组合物的制备方法,包括以下步骤:
1、将配方中的中药原料炮制粉碎后,过50目筛,室温下用水浸泡2小时;浸泡好的中药材,先用武火煮沸后,再用文火煎煮50min;
2、把煎煮中药原料制得的药液、药渣一起放入发酵罐内进行发酵,发酵罐内保持温度37℃;
3、发酵两周后,滤出发酵液;低温干燥成粉剂,灭菌消毒后装瓶,即制得治疗冠心病的中药制剂。
【临床资料】
1、基本资料
从2016年5月开始至今,对山东省临沂市经济技术开发区梅家埠街道卫生院和临沂市第三人民医院收治的维持阶段冠心病患者展开临床治疗及随访调查,经统计,共随访调查239例,女性132例,男性107例,年龄30-90岁。
2、病历排查及诊断标准:
239例患者使用本发明所述中药组合物治疗后进行项目排查,均在正常范围内,满足以下标准:
(1)无胸闷、气短、心悸,睡眠饮食可,二便调。
(2)血压稳定:平均血压在85-130mmHg/汞柱。
(3)心电图示:均正常。
(4)血脂、胆固醇、甘油三酯均正常。
(5)肝功、肾功、风湿、心肌酶谱均在正常范围内。
3、疗效判断:
根据调查结果判定药物疗效,疗效判定分为稳定、显效、有效、无效四个级别:
(1)稳定:患者诊断内的检测项目全部指标保持稳定,病情无复发,无并发症。
(2)显效:患者诊断内的检测项目80%以上指标保持稳定,病情无复发,无并发症。
(3)有效:患者诊断内的检测项目50%以上指标保持稳定,病情无复发,无并发症。
(4)无效:患者诊断内的检测项目全部指标无法保持稳定,三年内出现少量复发,个别患者出现并发症。
对上述239例维持阶段冠心病患者进行为期三年的跟踪调查,其中,疗效稳定的患者157人,显效的患者22人,有效的患者58人,无效的患者2人。
可见,本发明通过选取特定中药成分并限定具体的配比,经煎煮、发酵后制得的药剂用于维持阶段冠心病的治疗,能够显著降低维持阶段冠心病的复发,相对于现有治疗冠心病药剂的治疗效果更为显著,稳定性高、复发率低、出现并发症的概率小。
综上所述的实施例仅是对本发明的优选方式进行描述,并非对本发明的范围进行限定,在不脱离本发明设计精神的前提下,本领域普通技术人员对本发明的技术方案做出得出的各种变形和改进,均落入本发明权利要求书确定的保护范围内。
Claims (2)
1.一种用于治疗维持阶段冠心病的中药组合物,其特征在于:采用以下质量份数的原料配方制成:黄芪15-95份、阿胶5-50份、麦冬15-65份、红参15-55份、茯苓15-60份、熟地30-90份、烫龟甲15-45份、桂枝30-60份、柴胡20-60份、黄芩10-45份、川芎30-60份、煅紫石英10-30份、淫羊藿30-65份、金银花10-30份、丹参30-75份、牡丹皮15-30份、牛膝10-65份、郁金15-30份、炒枳实30-50份、全瓜蒌15-65份、枸杞15-65份、黑附子10-30份、炮姜10-20份、桃仁10-30份、红花10-30份、当归10-45份、大枣30-75份、生姜15-50份。
2.如权利要求1所述用于治疗维持阶段冠心病的中药组合物的制备方法,其特征在于:包括以下步骤:
(1)将配方中的中药原料炮制粉碎后,过50目筛,室温下用水浸泡1-2小时;浸泡好的中药材,先用武火煮沸后,再用文火煎煮40-60min;
(2)把煎煮中药原料制得的药液、药渣一起放入发酵罐内进行发酵,发酵罐内保持温度35-37℃;
(3)发酵两周后,滤出发酵液;低温干燥成粉剂,灭菌消毒后装瓶,即制得治疗冠心病的中药制剂。
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