CN114748383A - Skin-brightening lifting essence and preparation method thereof - Google Patents

Skin-brightening lifting essence and preparation method thereof Download PDF

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Publication number
CN114748383A
CN114748383A CN202110607055.9A CN202110607055A CN114748383A CN 114748383 A CN114748383 A CN 114748383A CN 202110607055 A CN202110607055 A CN 202110607055A CN 114748383 A CN114748383 A CN 114748383A
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Prior art keywords
skin
lifting
weight
parts
antioxidant
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Inventor
石毛
林志隆
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ANGLEE COSMETIC TECHNOLOGY CO LTD
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ANGLEE COSMETIC TECHNOLOGY CO LTD
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Priority to CN202110607055.9A priority Critical patent/CN114748383A/en
Publication of CN114748383A publication Critical patent/CN114748383A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/524Preservatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention discloses a skin-brightening lifting essence and a preparation method thereof, wherein the skin-brightening lifting essence comprises the following raw materials: humectant, skin conditioner, antioxidant, chelating agent, antiseptic, thickener, emulsifier, and water. The lifting essence disclosed by the invention contains multiple moistening components, and the prepared essence is excellent in moisturizing effect, can relieve the discomfort of skin, keep the skin moist and bright, has a good anti-aging effect, can enhance the skin barrier, protect the skin from environmental damage and improve the skin immunity by specifically compounding the multiple components, is small in stimulation to the skin, cannot generate a sensitization phenomenon, and also has a wide antibacterial spectrum.

Description

Skin-brightening lifting essence and preparation method thereof
Technical Field
The invention belongs to the field of skin care products, and particularly relates to a skin brightening lifting essence and a preparation method thereof.
Background
With the rapid development of society, scientific technology changes day by day, the competition intensity reaches the degree of white fever, and overtime and night battle become the normality of people in many workplaces. The normal work habits of people are disturbed by the shift work which is reversed day and night, and the shift work needs to face office appliances with radiation effects in offices such as computers for a long time, and the office appliances are left in an air-conditioned room with unsmooth air circulation for a long time, so that the skin is eroded by radiation, dryness, dust and residual makeup on the face, the skin is damaged, and the skin is dry and dark, loose and poor in elasticity and pores are obviously rough. With the continuous improvement of the living standard of the substances, the pursuit of beauty of people is also continuously improved, the people hope to change the appearance of the people to have bright and healthy skin color, and the beauty skin care product is expected to have more positive pharmacological effect. After work, delicate professional women pursuing fashion quality can comprehensively care and maintain facial skin by using essence or moisturizing lotion with a moisturizing function, and the like, so that skin injury and even aging caused by working overnight are avoided.
However, although many cosmetics in the market can play a certain effect on skin, such as moisturizing, improving rough skin and the like, the cosmetics often cause allergy to some people, so that the research and development of a safe and non-irritant skin care product with a certain effect has a very important application value.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the skin-brightening and lifting essence and the preparation method thereof, and the prepared essence is clear and not sticky through the specific compounding of multiple components, and simultaneously can inject vitality into the skin, relieve the discomfort of the skin and keep the skin moist and bright.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides a skin-brightening lifting essence which comprises the following raw materials: humectant, skin conditioner, antioxidant, chelating agent, antiseptic, thickener, emulsifier, and water.
As a preferable technical scheme, the composite material comprises the following raw materials in parts by weight: 7-14 parts of humectant, 0.1-0.55 part of skin conditioner, 2.6-3.7 parts of antioxidant, 0.02-0.06 part of chelating agent, 0.5-0.9 part of preservative, 0.1-0.15 part of thickening agent, 0.05-0.15 part of emulsifier and water to make up to 100 parts.
As a preferable technical scheme, the humectant comprises glycerin, panthenol and beta-glucan, wherein the weight ratio of the panthenol to the beta-glucan is (1-2): (1-4).
As a preferred embodiment, the skin conditioner comprises carboxymethyl chitosan, sodium hyaluronate and orange fruit extract.
As a preferable technical scheme, the molecular weight of the sodium hyaluronate is 1300-1500 KDa.
As a preferable technical scheme, the carboxymethyl chitosan is 0.05 to 0.35 part by weight, the sodium hyaluronate is 0.01 to 0.05 part by weight, and the citrus junos fruit extract is 0.05 to 0.15 part by weight.
As a preferable technical scheme, the preservative comprises caprylyl hydroximic acid and phenoxyethanol, and the weight ratio of the caprylyl hydroximic acid to the phenoxyethanol is (2-5): 1.
as a preferred embodiment, the antioxidant comprises allantoin and olive water.
As a preferable technical scheme, the antioxidant comprises 0.1-0.2 part of allantoin and 2.5-3.5 parts of olive fruit water in parts by weight.
The invention provides a preparation method of skin-brightening lifting essence, which comprises the following steps:
(1) weighing a skin conditioner, a thickening agent and a humectant into a container, and uniformly mixing to obtain a mixture A;
(2) And weighing water, a chelating agent, an antioxidant, an emulsifier and a preservative into the mixture A, stirring and dissolving until the mixture A is uniformly mixed, filtering by using gauze, and discharging to obtain the composition.
Has the beneficial effects that:
(1) the skin conditioner is compounded by specific components, firstly carboxymethyl chitosan and sodium hyaluronate generate synergistic action to endow the essence with extremely strong moisturizing capability, and meanwhile, a certain citrus junos extract is added to promote the proliferation of epidermal cells and inhibit the generation of red blood streak;
(2) the caprylyl hydroximic acid and the phenoxyethanol with specific proportions are used as preservatives, so that on one hand, the synergistic chelating agent inhibits the activity of metal ions in a system together, on the other hand, the bacteriostatic spectrum is expanded, the sensitization risk is greatly reduced, and meanwhile, the moisturizing capability can be improved;
(3) allantoin and olive fruit water are used as antioxidants, and the allantoin and olive fruit water generate a synergistic interaction effect to remove free radicals, inhibit lipid peroxidation and realize an excellent antioxidant effect on skin, so that the aim of delaying aging is fulfilled.
Detailed Description
The invention will be further understood by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definition provided in the present disclosure, the definition of the term provided in the present disclosure controls.
As used herein, a feature that is not limited to a single plural form is also intended to include plural forms of the feature unless the context clearly indicates otherwise. It will also be understood that the term "prepared from …," as used herein, is synonymous with "comprising," including, "comprising," "having," "containing," and/or "containing," when used in this specification denotes a stated composition, step, method, article, or apparatus, but does not preclude the presence or addition of one or more other compositions, steps, methods, articles, or apparatuses. Furthermore, the use of "preferred," "preferably," "more preferred," and the like, when describing embodiments of the present invention, is intended to refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
In order to achieve the above purpose, the invention provides a skin-brightening and lifting essence which comprises the following raw materials: humectant, skin conditioner, antioxidant, chelating agent, antiseptic, thickener, emulsifier, and water.
In some preferred embodiments, the feed comprises the following components in parts by weight: 7-14 parts of humectant, 0.1-0.55 part of skin conditioner, 2.6-3.7 parts of antioxidant, 0.02-0.06 part of chelating agent, 0.5-0.9 part of preservative, 0.1-0.15 part of thickening agent, 0.05-0.15 part of emulsifier and water to make up to 100 parts.
In some preferred embodiments, the humectant comprises glycerin, panthenol, and β -glucan, wherein the weight ratio of panthenol to β -glucan is (1-2): (1-4), preferably (1-1.5): (1-3), more preferably 1: 1.5.
in some preferred embodiments, the skin conditioning agent comprises carboxymethyl chitosan, sodium hyaluronate, and orange (CITRUS JUNOS) fruit extract.
In some preferred embodiments, the sodium hyaluronate has a molecular weight of 1300-.
In some preferred embodiments, the carboxymethyl chitosan is 0.05 to 0.35 parts, the sodium hyaluronate is 0.01 to 0.05 parts, and the orange (CITRUS JUNOS) fruit extract is 0.05 to 0.15 parts by weight.
Preferably, the carboxymethyl chitosan is 0.05 to 0.3 part by weight, the sodium hyaluronate is 0.01 to 0.03 part by weight, and the orange (CITRUS JUNOS) fruit extract is 0.1 part by weight.
The applicant finds that the synergistic effect can be generated in the system through compounding carboxymethyl chitosan and sodium hyaluronate, so that the essence has extremely strong moisturizing capability and also has a certain bacteriostatic effect, and the applicant thinks that the possible reason is that: the water molecules are fixed from two aspects through different action modes of the carboxymethyl chitosan and the water molecules, so that excellent moisture retention performance is generated, and on one hand, due to the special structure of the carboxymethyl chitosan, a molecular chain has a plurality of hydroxyl groups, and the carboxymethyl chitosan is combined with moisture through hydrogen bonds and keeps moisture; the applicant also unexpectedly finds that when the sodium hyaluronate with the molecular weight of 1300-1500KDa is adopted, the stratum corneum can be softened, the absorption of other moisturizers by the skin is promoted, particularly the absorption of panthenol and beta-glucan by the stratum corneum is promoted, and the panthenol can moisten the stratum corneum on the surface of the skin after penetrating into the stratum corneum, so that the stratum corneum has a strong moisturizing effect and can stimulate the growth of epithelial cells; the beta-glucan can enhance the metabolism of cells after penetrating into the horny layer and improve the immunocompetence of the skin, and when the beta-glucan and the horny layer are combined at a specific ratio, the beta-glucan and the horny layer can promote the increase of collagen and elastin in the skin, so that the skin protection barrier is enhanced. In addition, certain fructus Citri Junoris (Citrus JUNOS) extract can promote epidermal cell proliferation, inhibit red blood streak, and enhance skin allergy resistance.
In some preferred embodiments, the preservative comprises caprylhydroxamic acid and phenoxyethanol in a weight ratio of (2-5): 1.
preferably, the preservative comprises caprylyl hydroximic acid and phenoxyethanol, and the weight ratio of the caprylyl hydroximic acid to the phenoxyethanol is (2-3): 1.
more preferably, the preservative comprises caprylyl hydroximic acid and phenoxyethanol, and the weight ratio of the caprylyl hydroximic acid to the phenoxyethanol is 2.5: 1.
the cosmetic contains a large amount of nutritional ingredients such as fabric extract ingredients, grease and the like, is very beneficial to the growth and reproduction of microorganisms, loses the efficacy once polluted by the microorganisms and can stimulate the skin, so a certain preservative needs to be added into the cosmetic, in some existing cosmetics, phenoxyethanol is often used as the preservative, but the dosage of the phenoxyethanol needs to be strictly controlled, otherwise, the skin can be irritated and damaged, and the allergy phenomenon easily occurs. On one hand, the caprylyl hydroximic acid synergistic chelating agent inhibits the activity of metal ions in a system together and can also indirectly inhibit the growth of microorganisms, but the caprylyl hydroximic acid synergistic chelating agent has a single antibacterial spectrum and a weak antibacterial effect, the antibacterial spectrum can be expanded after a certain amount of phenoxyethanol is added, and the content of phenoxyethanol is obviously lower than the single dosage of phenoxyethanol preservative, so that the risk of stimulation to skin is greatly reduced.
In some preferred embodiments, the antioxidant comprises allantoin and olive (OLEA EUROPAEA) fruit water.
In some preferred embodiments, the antioxidant comprises allantoin 0.1-0.2 parts, olive (Olea EUROPAEA) fruit juice 2.5-3.5 parts by weight.
In order to endow cosmetics with anti-aging effect, a certain antioxidant needs to be added, the applicant finds that when the antioxidant added into the system adopts a specific allantoin and olive (OLEA EUROPAEA) fruit water ratio, not only can more excellent anti-oxidation effect be achieved, but also the skin can be more moisturized and glossy, the applicant considers that the possible reasons are that the allantoin can improve the hydrophilic power of skin stratum corneum protein molecules, repair damaged stratum corneum and form a water locking film on the skin surface to seal the loss of water, so as to reduce the generation of wrinkles, meanwhile, the olive (OLEA EUROPAEA) fruit water contains various polyphenols, and the active phenolic hydroxyl and benzene ring structures in the structure can well absorb ultraviolet light, the two have a synergistic effect, effectively remove free radicals, inhibit lipid peroxidation and achieve excellent anti-oxidation effect, thereby achieving the purpose of slowing down aging; in addition, allantoin can soften keratin, so that the intercellular space can be filled with water while metabolic aging keratin is peeled off, thereby realizing the moist luster of the skin.
In some preferred embodiments, the thickener is a carbomer or xanthan gum, preferably xanthan gum.
In some preferred embodiments, the chelating agent is disodium EDTA.
In some preferred embodiments, the emulsifier comprises PEG-40 hydrogenated castor oil \ PPG-26-Butaneth-26.
The invention provides a preparation method of skin-brightening lifting essence, which comprises the following steps:
(1) weighing a skin conditioner, a thickening agent and a humectant into a container, and uniformly mixing to obtain a mixture A;
(2) adding water, chelating agent, antioxidant, emulsifier and antiseptic into the mixture A, stirring and dissolving until uniformly mixed, filtering with gauze, and discharging.
Examples
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples 1 to 4 and comparative examples 1 to 4 each provide a skin lightening and lifting essence, and the raw materials for preparation are shown in table 1.
TABLE 1
Figure BDA0003090581870000051
Figure BDA0003090581870000061
Among them, carboxymethyl chitosan was purchased from impermans (china) limited; the xanthan gum is purchased from Hongyao chemical industry Co Ltd, and the model is CHOGUM T; allantoin was purchased from imperial (china) ltd; sodium hyaluronate was purchased from Huaxi Furuida biomedical Co., Ltd, model (HA-TP) 130-; PEG-40 hydrogenated Castor oil \ PPG-26 Butanepolyether-26 was purchased from Shanghai Senxin Biotech Co., Ltd; beta-glucan was purchased from SK Bioland; olive (OLEA EUROPAEA) fruit juice was purchased from guangzhou biosciences limited; panthenol was purchased from Roche; orange (CITRUS JUNOS) fruit extract was purchased from guangzhou biosciences limited.
The preparation method of the skin lightening and lifting essence described in examples 1 to 4 and comparative examples 1 to 4 includes the steps of:
(1) weighing a skin conditioner, a thickening agent and a humectant into a container, and uniformly mixing to obtain a mixture A;
(2) and (3) weighing water, a chelating agent, an antioxidant, an emulsifier and a preservative into the mixture A, stirring and dissolving until the mixture is uniformly mixed, filtering by using gauze, and discharging to obtain the composition.
Performance testing
1. Skin lightening test
The specific test method comprises the following steps: the skin color L value was measured using a Colorimeter CL400 manufactured by Courage Khazaka (CK) of Germany, and the influence thereof on the skin penetration was evaluated by measuring the change in the skin L value before and after the use of the product, and the products obtained in examples 1 to 4 and comparative examples 1 to 4 were tested by three groups of subjects having the same mean value of the initial L value, the age of the subjects was 18 to 35 years, 10 persons were each group, and the period was 4 weeks, and the results were averaged as shown in Table 1.
TABLE 1
Figure BDA0003090581870000071
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications and variations can be made in the present invention without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (10)

1. The skin-brightening and lifting essence is characterized by comprising the following raw materials: humectant, skin conditioner, antioxidant, chelating agent, antiseptic, thickener, emulsifier, and water.
2. The skin lightening and lifting essence as claimed in claim 1, which comprises the following raw materials in parts by weight: 7-14 parts of humectant, 0.1-0.55 part of skin conditioner, 2.6-3.7 parts of antioxidant, 0.02-0.06 part of chelating agent, 0.5-0.9 part of preservative, 0.1-0.15 part of thickener, 0.05-0.15 part of emulsifier and water to make up to 100 parts.
3. The skin lightening and lifting essence as claimed in claim 1 or 2, wherein the moisturizer comprises glycerin, panthenol and beta-glucan, and the weight ratio of the panthenol to the beta-glucan is (1-2): (1-4).
4. The skin lightening and lifting essence of claim 1 or 2 wherein the skin conditioning agent comprises carboxymethyl chitosan, sodium hyaluronate and orange fruit extract.
5. The skin lightening and lifting essence as claimed in claim 4, wherein the molecular weight of the sodium hyaluronate is 1300-1500 KDa.
6. The skin lightening and lifting essence according to claim 4, wherein the carboxymethyl chitosan is 0.05 to 0.35 part by weight, the sodium hyaluronate is 0.01 to 0.05 part by weight, and the citrus junos extract is 0.05 to 0.15 part by weight.
7. The skin lightening and lifting essence according to claim 1 or 2, wherein the preservative comprises caprylyl hydroximic acid and phenoxyethanol, and the weight ratio of the caprylyl hydroximic acid to the phenoxyethanol is (2-5): 1.
8. the skin lightening and lifting essence according to claim 1 or 2, wherein the antioxidant comprises allantoin and olive water.
9. The skin lightening and lifting essence according to claim 8, wherein the antioxidant comprises 0.1-0.2 parts of allantoin and 2.5-3.5 parts of olive fruit water by weight.
10. A method of preparing skin lightening and lifting essence according to any one of claims 1 to 9, comprising the steps of:
(1) weighing a skin conditioner, a thickening agent and a humectant into a container, and uniformly mixing to obtain a mixture A;
(2) and weighing water, a chelating agent, an antioxidant, an emulsifier and a preservative into the mixture A, stirring and dissolving until the mixture A is uniformly mixed, filtering by using gauze, and discharging to obtain the composition.
CN202110607055.9A 2021-05-28 2021-05-28 Skin-brightening lifting essence and preparation method thereof Pending CN114748383A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014182917A1 (en) * 2013-05-10 2014-11-13 Freelife International, Inc. Formulations and methods for improving skin conditions
CN111529438A (en) * 2020-04-14 2020-08-14 阿茹涵(广州)科技有限公司 Astaxanthin antioxidant essence and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014182917A1 (en) * 2013-05-10 2014-11-13 Freelife International, Inc. Formulations and methods for improving skin conditions
CN111529438A (en) * 2020-04-14 2020-08-14 阿茹涵(广州)科技有限公司 Astaxanthin antioxidant essence and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
国产普通化妆品备案信息网: "安婕妤无龄芯肌提拉原液", pages 1 - 3, Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakanHis.html?prodId=201909160857066g2x7&gb=G> *

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