CN114668809A - 一种用于改善整形美容副作用的药物 - Google Patents
一种用于改善整形美容副作用的药物 Download PDFInfo
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- CN114668809A CN114668809A CN202210229893.1A CN202210229893A CN114668809A CN 114668809 A CN114668809 A CN 114668809A CN 202210229893 A CN202210229893 A CN 202210229893A CN 114668809 A CN114668809 A CN 114668809A
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Abstract
本发明涉及一种用于改善整形美容副作用的药物。具体地,本发明提供一种原料药材或其提取物,所述的原料药材包含桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋。本发明所述的中药材或其提取物具有优异治疗疼痛的效果,从而可以用于改善整形美容带来的疼痛副作用。
Description
技术领域
本发明涉及整容领域,具体涉及一种用于改善整形美容副作用的药物。
背景技术
整形美容是指运用手术、药物、医疗器械以及其他医学技术方法对人的容貌和人体各部位形态进行的修复与再塑,进而增强人体外在美感为目的的科学性、技术性与艺术性极强的医学科学。随着人们生活水平的日益提高,生活质量有了很大的改变,对整形美容具有越来越高的追求。
然而,整形美容如整容手术也会带来副作用,其中,疼痛是整形美容中常见的副作用,疼痛副作用一直是美容手术中比较难解决的问题。整容手术后大部分给患者开消炎止痛药,但止痛疗效欠佳,并且西药、化学制品长期使用副作用大,有的含有大量激素,对人体伤害性较大,因此,本领域缺乏一种有效治疗整形美容导致的疼痛副作用的药物。
因此,本领域需要开发一种能够有效治疗整形美容导致的副作用的药物。
发明内容
本发明的目的在于提供一种能够有效治疗疼痛的原料药材或其提取物。
本发明第一个方面,提供一种原料药材或其提取物,所述的原料药材包含:
桑叶 | 30-50重量份 |
枇杷叶 | 1-10重量份 |
柏子仁 | 20-30重量份 |
山药 | 1-10重量份 |
枸杞子 | 1-10重量份 |
百合 | 10-20重量份 |
牡丹皮 | 5-15重量份;和 |
马齿苋 | 1-8重量份。 |
优选地,所述的原料药材包含:
桑叶 | 35-45重量份 |
枇杷叶 | 2-7重量份 |
柏子仁 | 22-28重量份 |
山药 | 2-7重量份 |
枸杞子 | 2-7重量份 |
百合 | 13-18重量份 |
牡丹皮 | 7-13重量份;和 |
马齿苋 | 1-5重量份。 |
优选地,所述的原料药材包含:
桑叶 | 38-42重量份 |
枇杷叶 | 4-6重量份 |
柏子仁 | 24-26重量份 |
山药 | 4-6重量份 |
枸杞子 | 4-6重量份 |
百合 | 14-16重量份 |
牡丹皮 | 8-12重量份;和 |
马齿苋 | 2-4重量份。 |
优选地,所述的原料药材包含:
桑叶 | 40重量份 |
枇杷叶 | 5重量份 |
柏子仁 | 25重量份 |
山药 | 5重量份 |
枸杞子 | 5重量份 |
百合 | 15重量份 |
牡丹皮 | 10重量份;和 |
马齿苋 | 3重量份。 |
优选地,所述的原料药材提取物为干浸膏。
优选地,所述的原料药材提取物为干提取物。
优选地,所述的提取物包括醇水溶液提取物。
优选地,所述的醇包括乙醇。
优选地,所述醇水溶液中,所述的醇的体积分数为55-75%,较佳地60-70%,更佳地63-67%。
优选地,所述的提取物包括乙醇水溶液提取物。
优选地,所述的乙醇水溶液中,所述的乙醇的体积分数为55-75%,较佳地60-70%,更佳地63-67%。
优选地,所述的原料药材提取物通过以下方法制备:
将桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋混合后粉碎,加入醇水溶液提取,得到原料药材提取物。
优选地,所述的原料药材提取物通过以下方法制备:
将桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋混合后,加入60-70%(v/v)乙醇水溶液,加热回流提取3.5-4.5h后,过滤,得到提取液,干燥,得到原料药材提取物。
优选地,所述的原料药材提取物通过以下方法制备:
将桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋混合后粉碎,加入5.8-6.2重量倍的63-67%(v/v)乙醇水溶液,加热回流提取3.8-4.2h后,过滤,得到提取液,干燥,得到中药材提取物。
本发明第二个方面提供一种组合物,所述的组合物包括如本发明第一个方面所述的原料药材或其提取物。
优选地,所述的组合物为药物组合物、食品组合物、保健品组合物或化妆品组合物。
优选地,所述的组合物还包括药学上、食品上、保健品上或化妆品上可接受的载体。
优选地,所述组合物的剂型为口服制剂、注射制剂、外用制剂。
优选地,所述组合物的剂型为皮肤用贴剂。
优选地,所述的如本发明第一个方面所述的原料药材或其提取物的含量为.01-99.9wt%,以组合物的重量计。
本发明第三个方面提供一种如本发明第一个方面所述的原料药材或其提取物的用途,用于制备组合物,所述的组合物用于(i)改善预防和/或治疗整形美容副作用;和/或(ii)预防和/或治疗疼痛的药物。
优选地,所述的整形美容副作用包括疼痛。
优选地,所述的疼痛包括炎症疼痛、急性疼痛和神经疼痛中的一种或多种。
优选地,所述的疼痛包括整形手术导致的疼痛。
本发明第四个方面提供一种预防和/或治疗疼痛的方法,给患者施用如本发明第一个方面所述的原料药材或其提取物。
应理解,在本发明范围内中,本发明的上述各技术特征和在下文(如实施例)中具体描述的各技术特征之间都可以互相组合,从而构成新的或优选的技术方案。
具体实施方式
本发明开发了一种中药材或其提取物,所述的原料药材包含桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋。本发明所述的中药材或其提取物具有优异治疗疼痛的效果,可以用于改善整形导致的疼痛副作用,从而降低整形导致的疼痛等副作用。
术语
如本文所用,术语“包括”、“包含”与“含有”可互换使用,不仅包括开放式定义,还包括半封闭式、和封闭式定义,所述术语包括了“由……构成”、“基本上由……构成”。
如本文所用,术语“原料药材或其提取物”与“原料药材或原料药材提取物”可互换使用。
如本文所用,术语“醇水溶液”与“醇水溶剂”可互换使用。当醇水溶剂或醇水溶液前有百分含量限定时,是指醇所占的体积百分比。例如,“65%乙醇水溶剂”、“65%乙醇水溶液”、“65%(v/v)乙醇水溶液”可互换使用,是指乙醇的体积分数为65%的乙醇水溶剂或乙醇的体积分数为65%的乙醇水溶液,例如,65%(v/v)乙醇水溶液是通过65ml无水乙醇+35ml水配制而得。
在本发明中,主要的原料药材的性能以及主要功效如下:
如本文所用,术语“桑叶”是指桑科植物桑Morus alba L.的干燥叶。
如本文所用,术语“枇杷叶”是指蔷薇科植物枇杷Eriobotrya japonica(Thunb.)Lindl.的干燥叶。
如本文所用,术语“柏子仁”是指为柏科植物侧柏Platycladus orientalis(L.)Franco的干燥成熟种仁。
在本发明中,术语“山药”是指薯蓣科植物薯蓣Dioscorea opposita Thunb.的干燥根茎。
如本文所用,术语“枸杞子”是指茄科植物枸杞Lycium barbarum L.的干燥成熟果实。
如本文所用,术语“百合”是指百合科植物百合Lilium brownii F.E.Brownvar.viridulum Baker的干燥肉质鳞叶。
如本文所用,术语“牡丹皮”是指毛茛科植物牡丹Paeonia suffruticosa Andr.的干燥根皮。
如本文所用,术语“马齿苋”是指马齿苋科植物马齿苋Portulaca oleracea L.,以全草入药。
原料药材或其提取物
本发明提供一种能够有效治疗疼痛的原料药材或其提取物。
在本发明的一个优选例中,所述的原料药材包含:
桑叶 | 30-50重量份 |
枇杷叶 | 1-10重量份 |
柏子仁 | 20-30重量份 |
山药 | 1-10重量份 |
枸杞子 | 1-10重量份 |
百合 | 10-20重量份 |
牡丹皮 | 5-15重量份;和 |
马齿苋 | 1-8重量份。 |
代表性地,所述的原料药材包含:
在本发明的一个优选例中,所述的提取物包括醇水溶液提取物。
优选地,所述的醇包括乙醇。
优选地,所述醇水溶液中,所述的醇的体积分数为55-75%,较佳地60-70%,更佳地63-67%。
代表性地,所述的提取物包括乙醇水溶液提取物。优选地,所述的乙醇水溶液中,所述的乙醇的体积分数为55-75%,较佳地60-70%,更佳地63-67%。
在本发明一个优选例中,所述的原料药材提取物通过以下方法制备:
将桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋混合后粉碎,加入醇水溶液提取,得到原料药材提取物。
在本发明一个优选例中,所述的原料药材提取物通过以下方法制备:
将桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋混合后,加入60-70%(v/v)乙醇水溶液,加热回流提取3.5-4.5h后,过滤,得到提取液,干燥,得到原料药材提取物。
典型地,所述的原料药材提取物通过以下方法制备:
将桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋混合后粉碎,加入5.8-6.2重量倍的63-67%(v/v)乙醇水溶液,加热回流提取3.8-4.2h后,过滤,得到提取液,干燥,得到中药材提取物。
组合物
本发明还提供一种组合物,所述的组合物包括本发明所述的原料药材或其提取物。
本发明所述的组合物可以为药物组合物、食品组合物、保健品组合物或化妆品组合物。
本发明所述的药物组合物还包括药学上可接受的载体。
如本文所用,术语“药学上可接受的载体”指的是:一种或多种相容性固体、半固体、液体或凝胶填料,它们适合于人体或动物使用,而且有足够的纯度和足够低的毒性。
应理解,在本发明中,所述的载体没有特别的限制,可选用本领域常用材料,或用常规方法制得,或从市场购买得到。药学可接受的载体部分例子有纤维素及其衍生物(如甲基纤维素、乙基纤维素、羟丙甲基纤维素、羧甲基纤维素钠等)、明胶、滑石粉、固体润滑剂(如硬脂酸、硬脂酸镁)、硫酸钙、植物油(如豆油、芝麻油等)、多元醇(如丙二醇、甘油、山梨醇等)、乳化剂(如吐温)、润湿剂(如十二烷基硫酸钠)、缓冲剂、螯合剂、增稠剂、pH调节剂、透皮促进剂、着色剂、调味剂、稳定剂、抗氧化剂、防腐剂、抑菌剂、无热原水等。
在本发明中,药物组合物的剂型包括(但不限于)口服制剂、注射制剂或外用制剂。
代表性地,所述药物组合物的剂型为片剂、注射剂、输液剂、膏剂、凝胶剂、溶液剂、微球或膜剂。
在本发明的一个优选例中,所述的药物组合物中,所述的原料药材或其提取物的含量为0.1-99.9wt%,较佳地10-90%,更佳地20-80%,更佳地30-70%,以药物组合物的重量计。
用途
本发明所述的原料药材或其提取物对本疼痛具有优异的治疗效果。在本发明中,疼痛并没有特别的限制,可以是炎症疼痛、急性疼痛和神经疼痛中的一种或多种。
在本发明中,术语“预防”表示预防疾病和/或它的附随症状的发作或者保护对象免于获得疾病的方法。本文中使用的"预防"还包括延迟疾病和/或它的附随症状的发作和降低对象的得病的风险。
本发明所述的“治疗”包括延缓和终止疾病的进展,或消除疾病,并不需要100%抑制、消灭和逆转。在一些实施方案中,与不存在本发明所述的原料药材或其提取物相比,本发明所述原料药材或其提取物将整形导致的疼痛副作用减轻、抑制和/或逆转了例如至少约10%、至少约30%、至少约50%、或至少约80%,或100%。
本发明取得的主要技术效果包括:
1、本发明所述的中药材或其提取物具有优异治疗疼痛的效果,从而可以用于改善整形美容带来的疼痛副作用。
2、本发明中药材或其提取物成药性好、成本低、便于工业化生产。
下面结合具体实施例,进一步阐述本发明。应理解,以下具体实施例以本技术方案为前提,给出了详细的实施方式和具体操作过程,但本发明的保护范围并不限于本实施例。
实施例1
本实施例1制备一种中药材提取物,制备方法如下:
将40g桑叶、5g枇杷叶、25g柏子仁、5g山药、5g枸杞子和3g马齿苋混合后粉碎,加入6重量倍的65%(v/v)乙醇水溶液,加热回流提取4h后,过滤,得到提取液,经旋转蒸发、干燥后,得到中药材提取物。
实施例2
本实施例2制备一种中药材提取物,制备方法如下:
将40g桑叶、5g山药、5g枸杞子、15g百合、10g牡丹皮和3g马齿苋混合后粉碎,加入6重量倍的65%(v/v)乙醇水溶液,加热回流提取4h后,过滤,得到提取液,经旋转蒸发、干燥后,得到中药材提取物。
实施例3
本实施例3制备一种中药材提取物,制备方法如下:
将40g桑叶、5g枇杷叶、25g柏子仁、5g山药、5g枸杞子、15g百合、10g牡丹皮和3g马齿苋混合后粉碎,加入6重量倍的65%(v/v)乙醇水溶液,加热回流提取4h后,过滤,得到提取液,经旋转蒸发、干燥后,得到中药材提取物。
实施例4
本实施例4制备一种中药材提取物,制备方法如下:
将40g桑叶、20g枇杷叶、10g柏子仁、5g山药、5g枸杞子、5g百合、20g牡丹皮和3g马齿苋混合后粉碎,加入6重量倍的65%(v/v)乙醇水溶液,加热回流提取4h后,过滤,得到提取液,经旋转蒸发、干燥后,得到中药材提取物。
效果例
效果例1
通过小鼠福尔马林疼痛模型考察实施例1-4制备的中药材提取物对急性疼痛、炎症疼痛的治疗效果
1.1实验方法
将健康雄性C57BL/6小鼠随机分成空白对照组、实验组1、实验组2、实验组3、实验组4,每组10只,实验开始前,让小鼠适应实验环境72h,自由饮水,各组小鼠按照如下给药方式进行灌胃给药:空白对照组小鼠给予生理盐水,实验组1的小鼠给予实施例1制备的中药材提取物(给药剂量为30mg/kg.bw.),实验组2的小鼠给予实施例2制备的中药材提取物(给药剂量为30mg/kg.bw.),实验组3的小鼠给予实施例3制备的中药材提取物(给药剂量为30mg/kg.bw.),实验组4的小鼠给予实施例4制备的中药材提取物(给药剂量为30mg/kg.bw.)。
给药后将小鼠置于透明有机玻璃圆筒内,1h后于各组小鼠左后足底以微量进样器注射4%福尔马林溶液20μl,以微型摄像机实时记录小鼠的足部疼痛反应,以舔左后足的时间长度作为疼痛反应的指标,分别观察记录0-60min内的舔足时间,进行统计学分析。
1.2实验结果
各组小鼠左后足底注射4%福尔马林溶液后,0-60min内的舔左后足时间如表1所示:
表1各组小鼠的添足时间(M±SD)
组 | 给药 | 添足时间统计(s) |
空白对照组 | 生理盐水 | 371±15 |
实验组1 | 实施例1制备的中药材提取物 | 297±26** |
实验组2 | 实施例2制备的中药材提取物 | 262±23** |
实验组3 | 实施例3制备的中药材提取物 | 142±12** |
实验组4 | 实施例4制备的中药材提取物 | 194±18* |
备注:与空白对照组比较,“*”为P<0.05,“**”为P<0.01。
从表1中可以看出,实施例1-4制备的中药材提取物对急性疼痛、炎症疼痛具有治疗效果。
效果例2
通过大鼠神经性疼痛模型考察实施例1-4制备的中药材提取物对神经性疼痛的治疗效果
2.1实验方法
2.2.1神经性疼痛模型的构建:
使用手术刀在健康雄性SD大鼠腰部荐骨后部开一纵向切口,暴露左侧椎旁肌,使用撑开器分离肌肉组织以暴露脊椎骨。分离左侧脊神经L5和L6,使用丝线结扎,缝合伤口。手术后,将动物放在实验环境中适应3天后,对大鼠进行机械痛觉超敏基线测试,将没有表现出机械痛觉超敏的动物(缩脚阈值大于5g)的动物剔除,从而构建神经性疼痛模型。
2.2.2给药和测定
将神经性疼痛模型大鼠随机模型组、实验组1、实验组2、实验组3、实验组4,每组10只,各组大鼠按照如下给药方式进行灌胃给药:模型组大鼠给予生理盐水,实验组1的大鼠给予实施例1制备的中药材提取物(给药剂量为30mg/kg.bw.),实验组2的大鼠给予实施例2制备的中药材提取物(给药剂量为30mg/kg.bw.),实验组3的大鼠给予实施例3制备的中药材提取物(给药剂量为30mg/kg.bw.),实验组4的大鼠给予实施例4制备的中药材提取物(给药剂量为30mg/kg.bw.)。
给药后,进行机械痛觉超敏测试。将大鼠单独放置在有机玻璃盒中,盒子底部为网格以保证大鼠脚部可以测试。在测试前大鼠将适应15min。适应完成后,使用测试纤维在大鼠左后脚脚底中心部位测试。测试纤维包括8个测试强度值:3.61(0.4g)、3.84(0.6g)、4.08(1g)、4.31(2g)、4.56(4g)、4.74(6g)、4.93(8g)、5.18(15g)。测试时,将测试纤维垂直压向皮肤并施力使纤维弯曲6-8秒,每次测试间隔5秒。测试时,动物迅速缩脚被记为疼痛反应。测试纤维离开动物皮肤时动物缩脚也被记为疼痛反应。如果动物移动或走动,不记疼痛反应,应重复测试。测试时首先使用2g,如果动物有疼痛反应,下一次测试使用力度小一级的测试纤维;如果动物没有疼痛反应,下一次测试使用力度大一级的测试纤维)。测试纤维的最大力度为15g。
机械痛觉超敏在大鼠行为学测试中表述为缩脚阈值(PWT),按照如下公式计算:
50%缩脚阈值(g)=(10(Xf+kδ))/10,000;
Xf=测试中使用的最终测试纤维值;
k=表值;
δ=平均差。
使用Prism 6.01(Graph pad software,Inc.)软件分析数据。缩脚阈值(PWT)数值越大,表明中药材提取物的镇痛药效越强。
2.2实验结果
各组神经性疼痛模型大鼠的缩脚阈值(PWT)如下表2所示:
表2各组大鼠的添足时间(M±SD)
组 | 给药 | PWT(g) |
模型组 | 生理盐水 | 4.3±0.3 |
实验组1 | 实施例1制备的中药材提取物 | 5.3±0.4 |
实验组2 | 实施例2制备的中药材提取物 | 5.9±0.4 |
实验组3 | 实施例3制备的中药材提取物 | 7.5±0.6 |
实验组4 | 实施例4制备的中药材提取物 | 7.0±0.5 |
从表2中可以看出,实施例1-4制备的中药材提取物对神经性疼痛具有治疗效果。
以上所述仅为本申请的优选实施例而已,并不用于限制本申请,对于本领域的技术人员来说,本申请可以有各种更改和变化。凡在本申请的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本申请的保护范围之内。
Claims (10)
1.一种原料药材或其提取物,其特征在于,所述的原料药材包含:
2.如权利要求1所述的原料药材或其提取物,其特征在于,所述的原料药材包含:
3.如权利要求1所述的原料药材或其提取物,其特征在于,所述的原料药材包含:
4.如权利要求1所述的原料药材或其提取物,其特征在于,所述的提取物包括醇水溶液提取物。
5.如权利要求1所述的原料药材或其提取物,其特征在于,所述的醇包括乙醇;
所述的醇水溶液中,所述的醇的体积分数为55-75%,较佳地60-70%,更佳地63-67%。
6.如权利要求1所述的原料药材或其提取物,其特征在于,所述的原料药材提取物通过以下方法制备:
将桑叶、枇杷叶、柏子仁、山药、枸杞子、百合、牡丹皮和马齿苋混合后,加入60-70%(v/v)乙醇水溶液,加热回流提取3.5-4.5h后,过滤,得到提取液,经旋转蒸发、干燥后,得到中药材提取物。
7.一种组合物,其特征在于,所述的组合物包括如权利要求1所述的原料药材或其提取物。
8.如权利要求7所述的组合物,其特征在于,所述的组合物为药物组合物、食品组合物、保健品组合物或化妆品组合物。
9.一种如权利要求1所述的原料药材或其提取物的用途,用于制备组合物,所述的组合物用于(i)改善预防和/或治疗整形美容副作用;和/或(ii)预防和/或治疗疼痛的药物。
10.如权利要求9所述的用途,其特征在于,所述的整形美容副作用包括疼痛。
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