CN114668679B - 育毛剂 - Google Patents
育毛剂 Download PDFInfo
- Publication number
- CN114668679B CN114668679B CN202210386649.6A CN202210386649A CN114668679B CN 114668679 B CN114668679 B CN 114668679B CN 202210386649 A CN202210386649 A CN 202210386649A CN 114668679 B CN114668679 B CN 114668679B
- Authority
- CN
- China
- Prior art keywords
- hair
- inositol
- growth
- shaft
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003779 hair growth Effects 0.000 title claims abstract description 70
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims abstract description 100
- 210000004919 hair shaft Anatomy 0.000 claims description 94
- 210000004209 hair Anatomy 0.000 claims description 83
- 230000031774 hair cycle Effects 0.000 claims description 45
- CDAISMWEOUEBRE-LKPKBOIGSA-N 1D-chiro-inositol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-LKPKBOIGSA-N 0.000 claims description 36
- 230000012010 growth Effects 0.000 claims description 17
- 230000001737 promoting effect Effects 0.000 claims description 15
- 239000011148 porous material Substances 0.000 claims description 8
- 230000002829 reductive effect Effects 0.000 claims description 6
- 238000004904 shortening Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000003797 telogen phase Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229960000367 inositol Drugs 0.000 abstract description 50
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract description 47
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 86
- 239000003795 chemical substances by application Substances 0.000 description 45
- 239000003814 drug Substances 0.000 description 43
- 229940079593 drug Drugs 0.000 description 39
- 239000000243 solution Substances 0.000 description 39
- 210000004027 cell Anatomy 0.000 description 27
- 230000000694 effects Effects 0.000 description 25
- 239000012085 test solution Substances 0.000 description 24
- 239000013642 negative control Substances 0.000 description 22
- 238000012360 testing method Methods 0.000 description 20
- 241000699666 Mus <mouse, genus> Species 0.000 description 16
- 230000035755 proliferation Effects 0.000 description 14
- 239000011248 coating agent Substances 0.000 description 13
- 238000000576 coating method Methods 0.000 description 13
- 239000001963 growth medium Substances 0.000 description 13
- 241000699670 Mus sp. Species 0.000 description 9
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 description 8
- 230000000284 resting effect Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000003698 anagen phase Effects 0.000 description 6
- CDAISMWEOUEBRE-NIPYSYMMSA-N epi-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](O)[C@H]1O CDAISMWEOUEBRE-NIPYSYMMSA-N 0.000 description 6
- 210000003780 hair follicle Anatomy 0.000 description 6
- 201000004384 Alopecia Diseases 0.000 description 5
- 238000011814 C57BL/6N mouse Methods 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 230000001256 tonic effect Effects 0.000 description 5
- 241000282567 Macaca fascicularis Species 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 229920001342 Bakelite® Polymers 0.000 description 3
- 206010022489 Insulin Resistance Diseases 0.000 description 3
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- 230000003656 anti-hair-loss Effects 0.000 description 3
- 230000003778 catagen phase Effects 0.000 description 3
- 238000012136 culture method Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
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- 239000008177 pharmaceutical agent Substances 0.000 description 3
- CDAISMWEOUEBRE-CDRYSYESSA-N scyllo-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-CDRYSYESSA-N 0.000 description 3
- 208000019300 CLIPPERS Diseases 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 208000030695 Sparse hair Diseases 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
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- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 2
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- 210000002615 epidermis Anatomy 0.000 description 2
- 210000002768 hair cell Anatomy 0.000 description 2
- 230000003662 hair growth rate Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000003658 preventing hair loss Effects 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 241001272567 Hominoidea Species 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
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- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
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- 235000020971 citrus fruits Nutrition 0.000 description 1
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 description 1
- 229960003843 cyproterone Drugs 0.000 description 1
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- 230000003676 hair loss Effects 0.000 description 1
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- 239000003676 hair preparation Substances 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
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- 244000144972 livestock Species 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
- 229960003105 metformin Drugs 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
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- 230000002040 relaxant effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
- 208000002271 trichotillomania Diseases 0.000 description 1
- 229940035722 triiodothyronine Drugs 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210386649.6A CN114668679B (zh) | 2016-04-27 | 2017-04-27 | 育毛剂 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016-100903 | 2016-04-27 | ||
| JP2016100903 | 2016-04-27 | ||
| JP2016-091063 | 2016-04-28 | ||
| JP2016091063 | 2016-04-28 | ||
| CN202210386649.6A CN114668679B (zh) | 2016-04-27 | 2017-04-27 | 育毛剂 |
| CN201780035127.9A CN109310598B (zh) | 2016-04-27 | 2017-04-27 | 育毛剂 |
| PCT/JP2017/016783 WO2017188393A1 (ja) | 2016-04-27 | 2017-04-27 | 育毛剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780035127.9A Division CN109310598B (zh) | 2016-04-27 | 2017-04-27 | 育毛剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114668679A CN114668679A (zh) | 2022-06-28 |
| CN114668679B true CN114668679B (zh) | 2024-06-25 |
Family
ID=60160827
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210386649.6A Active CN114668679B (zh) | 2016-04-27 | 2017-04-27 | 育毛剂 |
| CN201780035127.9A Active CN109310598B (zh) | 2016-04-27 | 2017-04-27 | 育毛剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780035127.9A Active CN109310598B (zh) | 2016-04-27 | 2017-04-27 | 育毛剂 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10933001B2 (enExample) |
| EP (2) | EP3449897B1 (enExample) |
| JP (2) | JP6244065B1 (enExample) |
| CN (2) | CN114668679B (enExample) |
| ES (1) | ES2983707T3 (enExample) |
| MY (1) | MY186907A (enExample) |
| SG (2) | SG10202107298RA (enExample) |
| WO (1) | WO2017188393A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7519753B2 (ja) * | 2018-06-29 | 2024-07-22 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7203521B2 (ja) * | 2018-06-29 | 2023-01-13 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7580183B2 (ja) * | 2018-06-29 | 2024-11-11 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7203522B2 (ja) * | 2018-06-29 | 2023-01-13 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7425536B2 (ja) * | 2018-12-28 | 2024-01-31 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む外用組成物 |
| JP7350498B2 (ja) * | 2019-03-14 | 2023-09-26 | 小林製薬株式会社 | 外用組成物 |
| CN117679486A (zh) | 2019-10-18 | 2024-03-12 | 安佳榜控股股份公司 | 毛乳头细胞的fgf-7促生成剂及vegf促生成剂 |
| US11491103B1 (en) * | 2020-07-02 | 2022-11-08 | Mahisha Jones | Hair growth formula |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006028026A (ja) * | 2004-07-12 | 2006-02-02 | Doctor Program Kk | 育毛剤 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0245407A (ja) | 1988-08-05 | 1990-02-15 | Yokohama Rubber Co Ltd:The | Ｌ−クエブラキトール化粧料 |
| ATE193440T1 (de) | 1989-03-08 | 2000-06-15 | Univ Virginia | Arzneimittel für insulinresistente diabetiker |
| US5428066A (en) * | 1989-03-08 | 1995-06-27 | Larner; Joseph | Method of reducing elevated blood sugar in humans |
| US5043162A (en) * | 1990-09-05 | 1991-08-27 | Trager Seymour F | Hair growth promoter |
| US5091596A (en) | 1990-12-20 | 1992-02-25 | Univ. Of Va. Alumni Patents Foundation | Method for producing chiro-inositol |
| US5906979A (en) * | 1998-01-27 | 1999-05-25 | Insmed Pharmaceuticals, Inc. | Compositions and methods for treating metabolic diseases characterized by hyperandrogenism and/or anovulation and/or infertility |
| US6342645B2 (en) * | 1999-12-30 | 2002-01-29 | Insmed Pharmaceuticals, Inc. | Methods for the production and isolation of D-chiro-inositol from kasugamycin and the use of D-chiro-inositol obtained therefrom |
| EP1267850B1 (en) | 2000-02-23 | 2007-04-11 | Orentreich Foundation for the Advancement of Science, Inc. | Use of insulin sensitivity increasing substances for the treatment of alopecia |
| US20020032177A1 (en) * | 2000-04-28 | 2002-03-14 | Insmed Pharmaceuticals, Inc. | Use of D-chiro-inositol in the treatment of conditions associated with hypothalamic gene expression |
| US6660891B2 (en) * | 2000-05-15 | 2003-12-09 | Insmed Incorporated | Methods for the production of D-chiro-inositol and the use of D-chiro inositol obtained therefrom |
| US20080103116A1 (en) | 2006-11-01 | 2008-05-01 | Jennings-Spring Barbara L | Method of treatment and compositions of D-chiro inositol and phosphates thereof |
| US20100055060A1 (en) | 2006-11-27 | 2010-03-04 | Naoyuki Yoshida | Cosmetic composition |
-
2017
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| JP2006028026A (ja) * | 2004-07-12 | 2006-02-02 | Doctor Program Kk | 育毛剤 |
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| JPWO2017188393A1 (ja) | 2018-05-10 |
| JP7005244B2 (ja) | 2022-02-10 |
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| JP6244065B1 (ja) | 2017-12-06 |
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| MY186907A (en) | 2021-08-26 |
| EP3449897B1 (en) | 2024-07-17 |
| US11534377B2 (en) | 2022-12-27 |
| WO2017188393A1 (ja) | 2017-11-02 |
| US10933001B2 (en) | 2021-03-02 |
| EP4417264A2 (en) | 2024-08-21 |
| US20210145713A1 (en) | 2021-05-20 |
| ES2983707T3 (es) | 2024-10-24 |
| EP3449897A4 (en) | 2020-01-15 |
| JP2018024692A (ja) | 2018-02-15 |
| CN109310598A (zh) | 2019-02-05 |
| EP4417264A3 (en) | 2024-11-20 |
| SG11201809434YA (en) | 2018-11-29 |
| SG10202107298RA (en) | 2021-08-30 |
| CN114668679A (zh) | 2022-06-28 |
| US20190133904A1 (en) | 2019-05-09 |
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