CN114643241A - Liquid supply system and liquid supply method - Google Patents
Liquid supply system and liquid supply method Download PDFInfo
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- CN114643241A CN114643241A CN202011506980.4A CN202011506980A CN114643241A CN 114643241 A CN114643241 A CN 114643241A CN 202011506980 A CN202011506980 A CN 202011506980A CN 114643241 A CN114643241 A CN 114643241A
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- waste liquid
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- 239000007788 liquid Substances 0.000 title claims abstract description 283
- 238000000034 method Methods 0.000 title claims abstract description 37
- 239000002699 waste material Substances 0.000 claims abstract description 204
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 129
- 238000005070 sampling Methods 0.000 claims abstract description 71
- 238000004140 cleaning Methods 0.000 claims abstract description 34
- 238000000338 in vitro Methods 0.000 abstract description 3
- 238000011010 flushing procedure Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 description 17
- 239000003085 diluting agent Substances 0.000 description 9
- 239000000523 sample Substances 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000003570 air Substances 0.000 description 3
- 238000007865 diluting Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002572 peristaltic effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000012080 ambient air Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000006226 wash reagent Substances 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/093—Cleaning containers, e.g. tanks by the force of jets or sprays
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- Engineering & Computer Science (AREA)
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Abstract
The application relates to the technical field of in-vitro diagnostic equipment, and particularly discloses a liquid supply system and a liquid supply method, wherein the liquid supply system at least comprises: sampling unit and waste liquid unit, sampling unit controllable direct with the waste liquid unit connection, wherein, sampling unit provides reagent for the waste liquid unit. Through the mode, the reagent can be distributed quickly, the time of the cleaning process is shortened, and the flushing force of the reagent on the waste liquid unit can be increased.
Description
Technical Field
The present application relates to the field of in vitro diagnostic equipment technology, and in particular, to a liquid supply system and a liquid supply method.
Background
In the existing in-vitro diagnostic equipment, a waste liquid pool is mainly used for collecting waste liquid generated in the running process of an instrument, the waste liquid contains various reagents, reaction products and samples, the working environment of the waste liquid pool is severe, and a special cleaning reagent is required to be used for cleaning the waste liquid pool.
This application inventor is at long-term research and development in-process, discovers prior art and when wasing the waste liquid pond, often need borrow the reaction tank of instrument inside to carry out the transfer, and generally speaking, the waste liquid pond jar body is more, and the transfer needs to be carried out many times, leads to whole cleaning process to consume time longer, and special cleaning reagent is also less to the dynamics of washing in waste liquid pond.
In addition, because the sample distribution syringe has a relatively small range, when the sample distribution syringe is used for distributing a special cleaning reagent to the reaction cells, the sample distribution syringe needs to go back and forth for many times to distribute the amount of one reaction cell enough, the reagent distribution time is long, and if the instrument has a plurality of reaction cells to be cleaned, the reagent distribution time is longer.
Therefore, there is a need for a liquid supply system and a liquid supply method.
Disclosure of Invention
The application aims at solving the problems existing in the prior art to a certain extent, and provides a liquid supply system and a liquid supply method, which can realize the quick distribution of reagents, shorten the time of a cleaning process and increase the cleaning strength of the reagents on a waste liquid unit.
In order to solve the technical problem, the application adopts a technical scheme that: providing a liquid supply system comprising at least: sampling unit and waste liquid unit, sampling unit controllable direct with the waste liquid unit connection, wherein, the sampling unit provides reagent for the waste liquid unit.
Compared with the prior art, the method has the following beneficial effects:
the liquid supply system of the present application includes at least: sampling unit and waste liquid unit because the sampling unit of this application is controllable directly with the waste liquid unit connection, consequently, can realize the very fast distribution of reagent, and shorten the time of cleaning process, can increase the washing dynamics of reagent to the waste liquid unit.
In order to solve the above technical problem, another technical solution adopted by the present application is: the method for supplying liquid corresponding to the liquid supply system comprises the following steps: under the action of negative pressure, the sampling unit conveys the reagent to the waste liquid unit through the connecting pipeline.
Compared with the prior art, the method has the following beneficial effects:
this application can realize the faster distribution of reagent in the waste liquid unit under the effect of negative pressure, and shortens the time of cleaning process, can increase the washing dynamics of reagent to the waste liquid unit.
In order to solve the above technical problem, the present application adopts another technical solution: providing a liquid supply method corresponding to the liquid supply system, wherein the method comprises the following steps: under the action of negative pressure, the sampling unit stores the reagent into the connecting pipeline; and under the action of positive pressure, adding the reagent in the connecting pipeline into the reaction tank through the sampling unit.
Compared with the prior art, the method has the following beneficial effects:
the application can realize the faster distribution of the reagent in the reaction tank and shorten the time of the cleaning process.
Drawings
In order to more clearly explain the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and that for those skilled in the art, other related drawings can be obtained from these drawings without inventive effort.
FIG. 1 is a first block diagram of a liquid supply system provided herein;
FIG. 2 is a second block diagram of a liquid supply system provided herein.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present application, as presented in the figures, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be obtained by a person skilled in the art without making creative efforts based on the embodiments of the present application, belong to the protection scope of the present application.
In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the sub-units or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
As shown in FIG. 1, the present application is directed to a liquid supply system 10, the liquid supply system 10 including at least: a sampling unit 11 and a waste liquid unit 12, the sampling unit 11 being controllably connected directly to the waste liquid unit 12, wherein the sampling unit 11 provides a reagent to the waste liquid unit 12.
The reagent of the present application may be a diluent, a reagent for washing, or a reagent for reaction.
The sampling unit 11 at least includes a first interface and a second interface. The first interface is used for injecting reagent, and the second interface is communicated with the waste liquid unit 12 through a connecting pipeline, and an electromagnetic valve can be arranged on the connecting pipeline.
Specifically, the sampling unit 11 is used to aspirate a certain amount of reagent and dispense it to the waste liquid unit 12. In one application scenario, the sampling unit 11 may aspirate a reagent, which may be a special wash reagent, from the sample tube. In another application scenario, the sampling unit 11 may also aspirate reagents from a reservoir. The reagent enters the sampling unit 11 from the first interface, and flows out to the waste liquid unit 12 through the second interface and the pipeline, so as to clean the waste liquid unit 12.
Compared with the prior art, the method has the following beneficial effects: the liquid supply system 10 of the present application includes at least: sampling unit 11 and waste liquid unit 12 because sampling unit 11 of this application is controllable directly to be connected with waste liquid unit 12, consequently, can realize the faster distribution of reagent, and shortens cleaning process's time, can increase the washing dynamics of reagent to waste liquid unit 12.
As shown in fig. 1, in one embodiment, the waste liquid unit 12 includes: a first waste liquid tank 121 and a second waste liquid tank 122. The sampling unit 11 is controllably connected to the first waste liquid tank 121 and the second waste liquid tank 122, respectively.
The liquid supply system 10 further comprises: a first solenoid valve LV4 and a first three-way joint LV 10.
The sampling unit 11 includes: a sampling needle 111.
A first end of the first three-way joint LV10 is selectively communicated with the second port through a first electromagnetic valve LV4, a second end of the first three-way joint LV10 is communicated with the first waste liquid pool 121, and a third end of the second three-way joint LV11 is communicated with the second waste liquid pool 122.
The sampling needle 111 has a hollow structure.
As shown in FIG. 1, in one embodiment, the liquid supply system 10 further includes: the first negative pressure source 123, the first negative pressure source 123 is controllably communicated with the first waste liquid pool 121 and/or the second waste liquid pool 122, and the first negative pressure source 123 is used for providing negative pressure for the first waste liquid pool 121 and/or the second waste liquid pool 122.
Specifically, the first negative pressure source 123 refers to a device capable of providing negative pressure, such as a piston pump, a diaphragm pump, a peristaltic pump, a plunger pump, a syringe, and an air compressor, when in use, the first negative pressure source 123 is used to establish working negative pressure in the first waste liquid pool 121 and/or the second waste liquid pool 122, and the working negative pressure is used to drive the reagent in the pipeline to flow to the first waste liquid pool 121 and/or the second waste liquid pool 122.
In the use process, the first end of the first three-way joint LV10 is communicated with the second interface through the first electromagnetic valve LV4, the first negative pressure source 123 works, and provides negative pressure for the first waste liquid pool 121 and/or the second waste liquid pool 122. At this time, the sampling needle 111 is controlled to move into the liquid storage tank storing the reagent, and after the sampling needle 111 sucks the reagent, the reagent flows out to the first waste liquid tank 121 and/or the second waste liquid tank 122 through the first electromagnetic valve LV4 and the first three-way joint LV10, so that the reagent cleans the first waste liquid tank 121 and/or the second waste liquid tank 122.
In an embodiment, the first negative pressure source 123 is simultaneously communicated with the first waste liquid pool 121 and/or the second waste liquid pool 122 to provide negative pressure for both the first waste liquid pool 121 and the second waste liquid pool 122, and the reagent simultaneously enters the first waste liquid pool 121 and the second waste liquid pool 122 through the first three-way joint LV10 to clean the first waste liquid pool 121 and the second waste liquid pool 122.
In one embodiment, the first three-way joint LV10 may be a three-way solenoid valve LV 10; in the use process, the first end of the three-way solenoid valve LV10 is selectively communicated with the second end of the three-way solenoid valve LV10 or the third end of the three-way solenoid valve LV10, so that the reagent only enters the first waste liquid pool or only enters the second waste liquid pool, and only the first waste liquid pool or only the second waste liquid pool is cleaned.
As shown in fig. 1, in an embodiment, the sampling unit 11 further includes: a syringe 112 and a reagent supply device 113. The syringe 112 is controllably connected to a reagent supply 113 and the waste liquid unit 12, respectively, for cleaning the tubing between the syringe 112 and the waste liquid unit 12 or for supplying reagents to the waste liquid unit 12.
Specifically, the liquid supply system 10 further comprises: the reagent supplying device comprises a second three-way joint LV11, a second electromagnetic valve LV1 and a third electromagnetic valve LV5, wherein a first end of the second three-way joint LV11 is communicated with the second interface, a second end of the second three-way joint LV11 is selectively communicated with a first end of the first three-way joint LV10 through a first electromagnetic valve LV4, a third end of the second three-way joint LV11 is selectively communicated with the injector 112 through a second electromagnetic valve LV1, and the reagent supplying device 113 is selectively communicated with the injector 112 through a third electromagnetic valve LV 5.
During use, the first end of the first three-way joint LV10 is still communicated with the second port through the first electromagnetic valve LV4, but the sampling needle 111 leaves the liquid storage tank storing the reagent; the first negative pressure source 123 operates and supplies negative pressure to the first waste liquid pool 121 and/or the second waste liquid pool 122. At this time, the third solenoid valve LV5 communicates the reagent supply device 113 and the syringe 112, the syringe 112 is driven, and the reagent in the reagent supply device 113 enters the first waste liquid pool 121 and/or the second waste liquid pool 122 through the syringe 112.
Further, the second electromagnetic valve LV1 communicates the injector 112 with the third end of the second three-way joint LV11, the first electromagnetic valve LV4 communicates the second end of the second three-way joint LV11 and the first end of the first three-way joint LV10, and the reagent flows out to the first waste liquid pool 121 and/or the second waste liquid pool 122 through the injector 112, the second electromagnetic valve LV1, the second three-way joint LV11, the first electromagnetic valve LV4 and the first three-way joint LV10 in sequence. The reagent may be a diluent, and the diluent is used to dilute the cleaning reagent or the reaction reagent in the first waste liquid pool 121 and/or the second waste liquid pool 122, and simultaneously wash the cleaning reagent or the reaction reagent remaining in the pipeline to the first waste liquid pool 121 and/or the second waste liquid pool 122.
As shown in FIG. 1, in one embodiment, a sampling needle 111 is used to aspirate reagent from a reagent supply 113. The sampling needle 111 is controllably connected to the waste liquid unit 12 for cleaning a line between the sampling needle 111 and the waste liquid unit 12 or supplying a reagent to the waste liquid unit 12.
Further, as shown in fig. 1, in an embodiment, the sampling unit 11 further includes a cleaning swab 114, and the liquid supply system 10 further includes: a second negative pressure source 115, a fourth solenoid valve LV2 and a fifth solenoid valve LV 3. The washing swab 114 is sleeved on the outer wall of the sampling needle 111, the second negative pressure source 115 is selectively communicated with the washing swab 114 through a fourth electromagnetic valve LV2, the reagent supply device 113 is selectively communicated with the washing swab 114 through a fifth electromagnetic valve LV3, and the second negative pressure source 115 is used for providing negative pressure for the washing swab 114.
Specifically, the second negative pressure source 115 refers to a device capable of providing negative pressure, such as a piston pump, a diaphragm pump, a peristaltic pump, a plunger pump, a syringe, and an air compressor, when in use, the second negative pressure source 115 is used for establishing working negative pressure in the washing swab 114, and the working negative pressure is used for driving the reagent in the pipeline to flow to the washing swab 114.
During use, the fourth electromagnetic valve LV2 communicates the cleaning swab 114 with the second negative pressure source 115, the fifth electromagnetic valve LV3 communicates the cleaning swab 114 with the reagent supply device 113, the second negative pressure source 115 works to provide negative pressure for cleaning the swab 114, and the reagent in the reagent supply device 113 is automatically cleaned from the cleaning swab 114 into the cleaning swab 114, so as to clean the outer wall of the sampling needle 111.
As shown in FIG. 1, in one embodiment, the liquid supply system 10 further includes: a first positive pressure source 124, the first positive pressure source 124 being controllably connected to the first waste reservoir 121 and the second waste reservoir 122, respectively.
Specifically, the liquid supply system 10 further includes: a third three-way joint, a fifth three-way joint, a sixth solenoid valve LV6, and a seventh solenoid valve LV 7. The first end of the third three-way joint is communicated with a first negative pressure source 123, the second end of the third three-way joint is selectively communicated with a first waste liquid pool 121 through a sixth electromagnetic valve LV6, and the third end of the third three-way joint is selectively communicated with a second waste liquid pool 122 through a seventh electromagnetic valve LV 7. The first end of the fifth three-way joint is communicated with a first positive pressure source 124, the second end of the fifth three-way joint is selectively communicated with a first waste liquid pool 121 through a sixth electromagnetic valve LV6, and the third end of the fifth three-way joint is selectively communicated with a second waste liquid pool 122 through a seventh electromagnetic valve LV 7.
First positive pressure source 124 refers to a device that can provide positive pressure, such as a piston pump, diaphragm pump, peristaltic pump, plunger pump, syringe, air compressor. Further, the first positive pressure source 124 may also be in direct communication with the ambient air. In use, the first positive pressure source 124 is used to inject gas into the first waste liquid pool 121 and/or the second waste liquid pool 122 to maintain the first waste liquid pool 121 and/or the second waste liquid pool 122 at a positive working pressure.
In the using process, the sixth electromagnetic valve LV6 communicates the second end of the third three-way joint with the first waste liquid tank 121, and the first negative pressure source 123 works and provides negative pressure for the first waste liquid tank 121. At this time, the cleaning reagent and/or the diluent in the pipeline flows out to the first waste liquid tank 121; the seventh electromagnetic valve LV7 communicates the third end of the third three-way joint with the second waste liquid tank 122, and the first negative pressure source 123 works and provides negative pressure for the second waste liquid tank 122. At this time, the cleaning reagent and/or the diluent in the pipe flow out to the second waste liquid tank 122.
Or, in use, the sixth electromagnetic valve LV6 communicates the second end of the fifth three-way joint with the first waste liquid tank 121, and the first positive pressure source 124 works to provide positive pressure to the first waste liquid tank 121. At this time, the liquid (including at least the washing reagent and/or the diluting liquid) in the first waste liquid tank 121 is discharged; the seventh electromagnetic valve LV7 communicates the third end of the fifth three-way joint with the second waste liquid tank 122, and the first positive pressure source 124 operates to provide positive pressure to the second waste liquid tank 122. At this time, the liquid (including at least the washing reagent and/or the diluting liquid) in the second waste liquid tank 122 is discharged.
As shown in FIG. 1, in an embodiment, the liquid supply system 10 further includes a first waste liquid treatment unit 13, an eighth solenoid valve LV8 and a ninth solenoid valve LV9, the first waste liquid tank 121 is selectively communicated with the first waste liquid treatment unit 13 through the eighth solenoid valve LV8, and the second waste liquid tank 122 is selectively communicated with the first waste liquid treatment unit 13 through the ninth solenoid valve LV 9.
The liquid in the first waste liquid tank 121 enters the first waste liquid treatment unit 13 from the seventh electromagnetic valve LV7, and the liquid in the second waste liquid tank 122 enters the first waste liquid treatment unit 13 from the eighth electromagnetic valve LV 8.
Specifically, in the use process, the sixth electromagnetic valve LV6 communicates the second end of the fifth three-way joint with the first waste liquid tank 121, the first positive pressure source 124 works and provides positive pressure for the first waste liquid tank 121, and the eighth electromagnetic valve LV8 communicates the first waste liquid tank 121 with the first waste liquid treatment unit 13. At this time, the liquid (including at least the washing reagent and/or the diluent) in the first waste liquid tank 121 is discharged to the first waste liquid treatment unit 13; the seventh electromagnetic valve LV7 communicates the third end of the fifth three-way joint with the second waste liquid tank 122, the first positive pressure source 124 works and provides positive pressure for the second waste liquid tank 122, and the ninth electromagnetic valve LV9 communicates the second waste liquid tank 122 with the first waste liquid treatment unit 13. At this time, the liquid (including at least the washing reagent and/or the diluting liquid) in the second waste liquid tank 122 is discharged to the first waste liquid treatment unit 13.
As shown in fig. 1, in one embodiment, the first waste liquid tank 121 and the second waste liquid tank 122 are also connected to other pipes in the sample analyzer.
Specifically, during use, the first positive pressure source 124 is used to provide positive pressure to the first waste liquid pool 121 and/or the second waste liquid pool 122, and waste liquid in other pipelines flows into the first waste liquid pool 121 and/or the second waste liquid pool 122.
As shown in FIG. 2, in one embodiment, the liquid supply system 10 further includes at least one reaction cell 116. The reaction chamber 116 of the present embodiment is controllably connected to the reagent supply device 113, and the reagent stored in the connection pipeline between the sampling unit 11 and the waste liquid unit 12 can be added to the reaction chamber 116 under the pressure of the first positive pressure source 124, so as to realize the one-time distribution of the reagent required by the reaction chamber.
Specifically, the reaction cell 116 communicates with the reagent supply device 113. Further, the liquid supply system 10 further includes a second waste liquid treatment unit 14 and a tenth electromagnetic valve LV12, and the reaction tank 116 is selectively communicated with the second waste liquid treatment unit 14 through the tenth electromagnetic valve LV 12.
Specifically, during use, the syringe 112 is driven, and the reagent in the reagent supply device 113 enters the reaction cell 116 through the syringe 112 to dilute the sample solution in the reaction cell 116. After the detection is finished, the tenth electromagnetic valve LV12 connects the reaction tank 116 and the second waste liquid treatment unit 14 to discharge the liquid in the reaction tank 116.
In one embodiment, a connection pipeline is provided between the sampling unit 11 and the waste liquid unit 12, and the connection pipeline is used for conveying a reagent or storing the reagent.
It should be noted that the flow rate of the liquid in the connecting pipeline must be limited within a preset range, and if the flow rate is not controlled, when the liquid in the connecting pipeline is driven to flow by negative pressure, if the flow rate of the liquid is too large, the liquid in the first waste liquid tank 121 and the liquid in the second waste liquid tank 122 may be unevenly distributed. Therefore, the liquid resistance of the connecting pipeline is larger than or equal to the preset resistance value.
Specifically, as shown in fig. 1, the connection pipeline in the present application includes at least: the resistance of the pipeline between the second electromagnetic valve LV1 and the first three-way joint LV10, the pipeline between the first three-way joint LV10 and the first waste liquid tank 121, and the pipeline between the first three-way joint LV10 and the second waste liquid tank 122 is greater than or equal to a preset resistance value, so as to reduce the flow rate of the liquid inside the pipeline between the second electromagnetic valve LV1 and the first three-way joint LV10, the pipeline between the first three-way joint LV10 and the first waste liquid tank 121, and the pipeline between the first three-way joint LV10 and the second waste liquid tank 122, and to make the distribution of the cleaning reagent and/or the diluent between the first waste liquid tank 121 and the second waste liquid tank 122 more uniform.
In an embodiment, a liquid supply method is provided, which is performed based on the liquid supply system 10 in fig. 1, and which can be applied to any situation where it is necessary to clean the waste liquid unit 12.
The liquid supply method comprises the following steps:
s10: under the action of negative pressure, the sampling unit 11 delivers the reagent to the waste liquid unit 12 through the connecting line.
Specifically, the flow of the liquid supply method performed based on the liquid supply system 10 in fig. 1 is as follows:
step 11: when the first negative pressure source 123 is operated by opening the first solenoid valve LV4, the second solenoid valve LV1, and the third solenoid valve LV5 to drive the syringe 112, a small amount of the reagent in the reagent supply device 113 flows out to the first waste liquid tank 121 and the second waste liquid tank 122 through the syringe 112, the second solenoid valve LV1, the second three-way joint LV11, the first solenoid valve LV4, and the first three-way joint LV10, respectively.
Step 12: the first solenoid valve LV4, the second solenoid valve LV1 and the third solenoid valve LV5 are closed.
Step 13: the sampling needle 111 moves into the liquid storage tank storing the reagent and is positioned below the liquid level of the reagent, the first electromagnetic valve LV4 is opened, the reagent enters the sampling needle 111 and flows out to the first waste liquid tank 121 and the second waste liquid tank 122 through the sampling needle 111, the first electromagnetic valve LV4 and the first three-way joint LV10 respectively, so that the reagent cleans the first waste liquid tank 121 and the second waste liquid tank 122.
In this step, in order to ensure that the negative pressures in the first waste liquid tank 121 and the second waste liquid tank 122 are consistent, and the amounts of reagents entering the first waste liquid tank 121 and the second waste liquid tank 122 are consistent, the resistances of the pipeline between the second electromagnetic valve LV1 and the first three-way joint LV10, the pipeline between the first three-way joint LV10 and the first waste liquid tank 121, and the pipeline between the first three-way joint LV10 and the second waste liquid tank 122 are greater than or equal to a preset resistance value;
step 14: when the first solenoid valve LV4, the second solenoid valve LV1, and the third solenoid valve LV5 are opened, the injector 112 is driven, and the first negative pressure source 123 is operated, at this time, the reagent is injected again into the first waste liquid tank 121 and the second waste liquid tank 122, and simultaneously, the reagent remaining in the pipe is flushed to the first waste liquid tank 121 and the second waste liquid tank 122 by the reagent.
Step 15: the third solenoid valve LV5 and the fourth solenoid valve LV2 are opened while the sampling needle 111 is vertically reset, the second negative pressure source 115 is operated to provide negative pressure to the wash swab 114, and the reagent in the reagent supply 113 self-cleans the wash swab 114 into the wash swab 114, thereby cleaning the outer wall of the sampling needle 111.
Step 16: after soaking and cleaning of the first waste liquid pool 121 and the second waste liquid pool 122 are completed, the first solenoid valve LV4, the second solenoid valve LV1 and the third solenoid valve LV5 are closed, the eighth solenoid valve LV8, the ninth solenoid valve LV9, the sixth solenoid valve LV6 and the seventh solenoid valve LV7 are opened, and liquid in the first waste liquid pool 121 and the second waste liquid pool 122 is discharged.
This application can realize the faster distribution of reagent in the waste liquid unit under the effect of negative pressure, and shortens the time of cleaning process, can increase the washing dynamics of reagent to the waste liquid unit.
In an embodiment, a liquid supply method is provided, which is performed based on the liquid supply system 10 in fig. 2, and which can be applied to any situation where it is necessary to clean the waste liquid unit 12.
The liquid supply method comprises the following steps:
s20: under the effect of the negative pressure, the sampling unit 11 stores the reagent into the connecting line.
S30: under the action of positive pressure, the reagent in the connecting pipeline is added into the reaction tank 116 through the sampling unit 11.
Specifically, the flow of the liquid supply method is as follows:
step 21: when the first negative pressure source 123 is operated by opening the first solenoid valve LV4, the second solenoid valve LV1, and the third solenoid valve LV5 to drive the syringe 112, a small amount of the reagent in the reagent supply device 113 flows out to the first waste liquid tank 121 and the second waste liquid tank 122 through the syringe 112, the second solenoid valve LV1, the second three-way joint LV11, the first solenoid valve LV4, and the first three-way joint LV10, respectively.
Step 22: the first solenoid valve LV4, the second solenoid valve LV1 and the third solenoid valve LV5 are closed.
Step 23: the sampling needle 111 moves to a liquid storage tank storing a reagent and is positioned below the liquid level of the reagent, the first electromagnetic valve LV4 is opened, the reagent enters the liquid storage cavity of the sampling needle 111 and flows out to the first waste liquid tank 121 and the second waste liquid tank 122 through the sampling needle 111, the first electromagnetic valve LV4 and the first three-way joint LV10 respectively, so that the reagent cleans the first waste liquid tank 121 and the second waste liquid tank 122.
Step 24: when the first solenoid valve LV4, the second solenoid valve LV1, and the third solenoid valve LV5 are opened, the syringe 112 is driven, and the first negative pressure source 123 is operated, the diluent is injected into the first waste liquid tank 121 and the second waste liquid tank 122 again, and the reagent remaining in the pipe is flushed to the first waste liquid tank 121 and the second waste liquid tank 122 by the reagent.
Step 25: the fourth solenoid valve LV2 and the fifth solenoid valve LV3 are opened, the sampling needle 111 is vertically reset, the second negative pressure source 115 is operated to provide negative pressure to wash the swab 114, and the reagent in the reagent supply 113 self-cleans the swab 114 and enters the wash swab 114, thereby cleaning the outer wall of the sampling needle 111.
Step 26: the sampling needle 111 moves into the reservoir storing the reagent and is located below the liquid level of the reagent, the first electromagnetic valve LV4 is opened, the first negative pressure source 123 is turned on, and the reagent is stored in the connection line through the sampling unit 11.
Step 27: the sampling needle 111 is moved into the reaction cell 116, the reagent in the connection line between the sampling unit 11 and the waste liquid unit 12 is injected into the reaction cell 116, and an appropriate amount of diluent is added to the reaction cell 116 through the reagent supply device 113 to dilute the cleaning reagent.
Step 28: after the soaking and cleaning of the first waste liquid pool 121, the second waste liquid pool 122 and the reaction pool 116 are completed, the first solenoid valve LV4, the second solenoid valve LV1 and the third solenoid valve LV5 are closed, the tenth solenoid valve LV12, the eighth solenoid valve LV8, the ninth solenoid valve LV9, the sixth solenoid valve LV6 and the seventh solenoid valve LV7 are opened, and the liquid in the first waste liquid pool 121, the second waste liquid pool 122 and the reaction pool 116 is discharged.
Since the pipeline between the sampling needle 111 and the second three-way joint LV11 is also filled with reagent and can be directly used for reagent dispensing of the reaction cell 116, the sampling needle 111 does not need to repeatedly go to and from the reaction cell and the sampling site, and the dispensing time of the cleaning reagent is further saved. In addition, the present application may enable faster distribution of reagents within the reaction cell, and shorten the time of the washing process.
In one embodiment, the sample analyzer of the present application includes at least: the liquid supply system 10 of the above embodiment.
While the application has been described in the specification and drawings with reference to specific embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the application as defined in the claims. Furthermore, the combination and arrangement of features, elements and/or functions between specific embodiments herein is clearly apparent and thus, in light of this disclosure, one skilled in the art will appreciate that features, elements and/or functions of an embodiment may be incorporated into another embodiment as appropriate, unless described otherwise, above.
In addition, many modifications may be made to adapt a particular situation or material to the teachings of the application without departing from the essential scope thereof. Therefore, it is intended that the present application not be limited to the particular embodiments illustrated by the drawings and described in the specification as the best mode presently contemplated for carrying out the present application, but that the present application will include all embodiments falling within the scope of the foregoing description and the appended claims.
Claims (10)
1. A liquid supply system, characterized in that the liquid supply system comprises at least: a sampling unit and a waste liquid unit;
the sampling unit is controllably connected directly to the waste unit, wherein the sampling unit provides reagents to the waste unit.
2. The liquid supply system of claim 1, wherein the waste liquid unit comprises at least: the sampling unit is controllably connected with the first waste liquid pool and the second waste liquid pool respectively.
3. The liquid supply system of claim 2, wherein a connecting pipeline is arranged between the sampling unit and the waste liquid unit, and the connecting pipeline is used for conveying a reagent or storing the reagent.
4. The liquid supply system of claim 3, wherein the hydraulic resistance of the connecting line is greater than or equal to a predetermined resistance value.
5. The liquid supply system of claim 3, further comprising at least one reaction cell, a reagent supply, and a first positive pressure source, wherein the first positive pressure source is controllably connected to the first waste liquid tank and the second waste liquid tank, respectively, the reaction cell is controllably connected to the reagent supply, and the reagent stored in the connection line is added to the reaction cell under the pressure of the first positive pressure source.
6. The liquid supply system of claim 2, further comprising: the first negative pressure source is controllably communicated with the first waste liquid pool and/or the second waste liquid pool, and the first negative pressure source is used for providing negative pressure for the first waste liquid pool and/or the second waste liquid pool.
7. The liquid supply system of claim 2, wherein the sampling unit comprises at least: an injector and a reagent supply device;
the injector is controllably connected with the reagent supply device and the waste liquid unit respectively and is used for cleaning a pipeline between the injector and the waste liquid unit or providing a reagent for the waste liquid unit.
8. The liquid supply system of claim 2, wherein the sampling unit comprises at least: a sampling needle and a reagent supply device, the sampling needle being for aspirating a reagent from the reagent supply device;
the sampling needle is controllably connected with the waste liquid unit and is used for cleaning a pipeline between the sampling needle and the waste liquid unit or providing a reagent for the waste liquid unit.
9. A liquid supply method corresponding to the liquid supply system according to any one of claims 3 to 4 and 6 to 8, wherein the method comprises:
under the action of negative pressure, the sampling unit conveys the reagent to the waste liquid unit through the connecting pipeline.
10. A liquid supply method corresponding to the liquid supply system according to any one of claims 3 and 5 to 8, characterized in that the method comprises the following steps:
under the action of negative pressure, the sampling unit stores the reagent to the connecting pipeline;
and under the action of positive pressure, adding the reagent in the connecting pipeline into the reaction tank through the sampling unit.
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| CN114798614A (en) * | 2022-06-28 | 2022-07-29 | 深圳市帝迈生物技术有限公司 | Cleaning device and cleaning method for sample analyzer and sample analyzer |
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