CN114643240A - Cleaning system, sample analyzer and cleaning method - Google Patents
Cleaning system, sample analyzer and cleaning method Download PDFInfo
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- CN114643240A CN114643240A CN202011506938.2A CN202011506938A CN114643240A CN 114643240 A CN114643240 A CN 114643240A CN 202011506938 A CN202011506938 A CN 202011506938A CN 114643240 A CN114643240 A CN 114643240A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/0804—Cleaning containers having tubular shape, e.g. casks, barrels, drums
- B08B9/0817—Cleaning containers having tubular shape, e.g. casks, barrels, drums by agitating or tumbling containers filled with liquid or liquid and abrasive, e.g. chain
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
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Abstract
The application relates to the technical field of medical equipment, and specifically discloses a cleaning system, a sample analyzer and a cleaning method, wherein the cleaning system comprises: the liquid supply device comprises a waste liquid pool unit, a liquid supply unit, a positive pressure source and a negative pressure source. And the waste liquid pool unit comprises two waste liquid pools. And the liquid supply unit is used for supplying at least cleaning reagents for the two waste liquid pools. And the positive pressure source is selectively communicated with the at least one waste liquid pool and is used for providing positive pressure for the at least one waste liquid pool. And the negative pressure source is selectively communicated with the at least one waste liquid pool and is used for providing negative pressure for the at least one waste liquid pool. Wherein bubbles are bubbled in the washing reagent in the waste liquid pool having negative pressure by intermittently communicating the waste liquid pool having negative pressure with the waste liquid pool maintained at positive pressure. Through the mode, the flowability of the fluid in the waste liquid pool is enhanced, and the cleaning effect of the waste liquid pool is improved.
Description
Technical Field
The present application relates to the field of medical device technology, and in particular, to a cleaning system, a sample analyzer, and a cleaning method.
Background
Among the current medical instrument, the waste liquid pond mainly used collects the waste liquid that the instrument operation in-process produced, and the waste liquid contains multiple reagent, reaction product and sample, and the operational environment in waste liquid pond is abominable, needs to use special cleaning reagent to wash the waste liquid pond.
In the long-term research and development process, the inventor finds that the cleaning effect is difficult to guarantee due to the lack of effective uniformly mixing means and the over stable fluid in the waste liquid pool in the existing waste liquid pool soaking and cleaning process.
Therefore, it is necessary to provide a cleaning system, a sample analyzer and a cleaning method.
Disclosure of Invention
The application aims at solving the problems existing in the prior art to a certain extent, and provides a cleaning system, a sample analyzer and a cleaning method, so that the flowability of fluid in a waste liquid pool is enhanced, and the cleaning effect of the waste liquid pool is improved.
In order to solve the technical problem, the application adopts a technical scheme that: providing a cleaning system comprising: the waste liquid pool unit comprises two waste liquid pools; the liquid supply unit is used for providing reagents for the two waste liquid pools, and the reagents at least comprise cleaning reagents; a positive pressure source controllably connected to the two waste liquid pools, respectively; a negative pressure source controllably connected to the two waste liquid pools, respectively; wherein, negative pressure source provides negative pressure for one of them waste liquid pond, and positive pressure source provides positive pressure for one of them waste liquid pond to the bubble is bloated in the washing reagent in the waste liquid pond that has negative pressure through two waste liquid ponds of intermittent communication.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a sample analyzer comprising: as with the previously described cleaning system, the cleaning system is used to clean the waste reservoir.
In order to solve the technical problem, the application adopts a technical scheme that: providing a cleaning method based on the cleaning system, wherein the cleaning method comprises the following steps: providing negative pressure for the first waste liquid pool through a negative pressure source, and providing positive pressure for the second waste liquid pool through a positive pressure source; the first waste liquid tank and the second waste liquid tank are intermittently communicated to bubble out the washing reagent in the first waste liquid tank.
Compared with the prior art, the method has the following beneficial effects:
the cleaning system of the present application includes: the liquid supply unit provides at least cleaning reagents for the two waste liquid pools, the negative pressure source can provide negative pressure for one of the waste liquid pools, the positive pressure source can continuously provide positive pressure for the other waste liquid pool, the waste liquid pool with the negative pressure and the other waste liquid pool with the positive pressure are intermittently communicated, so that gas in the waste liquid pool with the positive pressure is driven to enter the other waste liquid pool with the negative pressure, bubbles are blown out from the cleaning reagents in the waste liquid pool with the negative pressure, interaction between two or more waste liquid tank bodies is realized by using a positive-negative pressure switching mode, and the cleaning reagents and other liquids (such as diluent) in the waste liquid pool with the negative pressure violently move by blowing the bubbles out, so that the cleaning reagents and other liquids (such as diluent) are fully and uniformly mixed, and the uniformly mixing effect is good; when realizing that cleaning agent and other liquid (for example diluent) mixing, liquid such as cleaning agent in the waste liquid pond constantly assaults waste liquid pond inner wall under the violent motion to the cleaning performance in waste liquid pond has been promoted.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and that those skilled in the art can also derive other related drawings based on these drawings without inventive effort.
Fig. 1 is a block diagram of a cleaning system according to a first embodiment of the present disclosure;
FIG. 2 is a block diagram of a cleaning system according to a second embodiment of the present application;
fig. 3 is a block diagram of a cleaning system according to a third embodiment of the present application;
fig. 4 is a block diagram of a cleaning system according to a fourth embodiment of the present application;
fig. 5 is a block diagram of a cleaning system according to a fifth embodiment of the present application;
fig. 6 is a block diagram of a cleaning system according to a sixth embodiment of the present application;
FIG. 7 is a schematic flow chart of a cleaning method according to a first embodiment of the present disclosure;
FIG. 8 is a schematic flowchart of step S11 in FIG. 7;
FIG. 9 is a schematic flowchart of step S11 in FIG. 7;
FIG. 10 is a schematic flowchart of step S12 in FIG. 7;
fig. 11 is a schematic flow chart of a cleaning method according to a fifth embodiment of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present application, as presented in the figures, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be obtained by a person skilled in the art without making creative efforts based on the embodiments of the present application, belong to the protection scope of the present application.
In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the sub-units or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present application, it should be noted that the terms "mounted," "connected," and "connected" are to be construed broadly and may include, for example, a fixed connection, a removable connection, or an integral connection unless expressly stated or limited otherwise. Either mechanically or electrically. They may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in this application will be understood to be a specific case for those of ordinary skill in the art.
As shown in fig. 1, the present application proposes a washing system 100, the washing system 100 comprising: a waste liquid tank unit 10, a liquid supply unit 40, a positive pressure source 20, and a negative pressure source 30.
The waste liquid tank unit 10 includes two waste liquid tanks, and it should be noted that the waste liquid tank unit 10 may further include a plurality of waste liquid tanks, for example, 3 waste liquid tanks, 4 waste liquid tanks, and the like.
The liquid supply unit 40 is used for supplying at least cleaning reagents for the two waste liquid pools. Positive pressure source 20 is controllably connected to each of the two waste reservoirs, and negative pressure source 30 is controllably connected to each of the two waste reservoirs.
The negative pressure source 30 refers to a device that can provide negative pressure, such as a piston pump, diaphragm pump, peristaltic pump, plunger pump, syringe, air compressor,
further, the waste liquid tank unit 10 may include a first waste liquid tank 11 and a second waste liquid tank 12, and the first waste liquid tank 11 and the second waste liquid tank 12 are controllably connected and share a set of drainage lines. In use, the negative pressure source 30 may provide negative pressure to the first waste reservoir 11 and the positive pressure source 20 may provide positive pressure to the second waste reservoir 12.
Specifically, the positive pressure source 20 continuously provides positive pressure to the second waste liquid tank 12, and the negative pressure source 30 provides negative pressure to the first waste liquid tank 11, after the pressure inside the first waste liquid tank 11 and the second waste liquid tank 12 is stabilized, the negative pressure source 30 stops providing negative pressure to the first waste liquid tank 11, and the positive pressure source 20 continuously provides positive pressure to the second waste liquid tank 12, at this time, the first waste liquid tank 11 and the second waste liquid tank 12 are temporarily communicated, so that the positive pressure inside the second waste liquid tank 12 enters the first waste liquid tank 11, the negative pressure inside the first waste liquid tank 11 is neutralized to cause reverse flow of gas, bubbles are blown out in the cleaning reagent inside the first waste liquid tank 11, and the fluidity of the cleaning reagent inside the first waste liquid tank 11 is increased, thereby cleaning the first waste liquid tank 11 is realized. Further, after the pressure inside the second waste liquid tank 12 is stabilized, the negative pressure source 30 stops supplying the negative pressure to the first waste liquid tank 11, and at this time, the first waste liquid tank 11 and the second waste liquid tank 12 are temporarily communicated again. The above process is repeated until the first waste liquid tank 11 is cleaned.
Compared with the prior art, the method has the following beneficial effects:
the cleaning system of the present application includes: the liquid supply unit provides at least cleaning reagents for the two waste liquid pools, the negative pressure source can provide negative pressure for one of the waste liquid pools, the positive pressure source can continuously provide positive pressure for the other waste liquid pool, the waste liquid pool with the negative pressure and the other waste liquid pool with the positive pressure are intermittently communicated, so that gas in the waste liquid pool with the positive pressure is driven to enter the other waste liquid pool with the negative pressure, bubbles are blown out from the cleaning reagents in the waste liquid pool with the negative pressure, interaction between two or more waste liquid tank bodies is realized by using a positive-negative pressure switching mode, and the cleaning reagents and other liquids (such as diluent) in the waste liquid pool with the negative pressure violently move by blowing the bubbles out, so that the cleaning reagents and other liquids (such as diluent) are fully and uniformly mixed, and the uniformly mixing effect is good; when realizing that cleaning agent and other liquid (for example diluent) mixing, liquid such as cleaning agent in the waste liquid pond constantly assaults waste liquid pond inner wall under the violent motion to the cleaning performance in waste liquid pond has been promoted.
As shown in fig. 2, in an embodiment, the washing system 100 further includes: a first three-way valve LV10, a second three-way valve LV11, a first three-way solenoid valve LV8, and a second three-way solenoid valve LV 9.
A first port of the first three-way valve LV10 is connected to the positive pressure source 20, a second port of the first three-way valve LV10 is selectively communicated with the first waste liquid tank 11 through a first three-way electromagnetic valve LV8, and a third port of the first three-way valve LV10 is selectively communicated with the second waste liquid tank 12 through a second three-way electromagnetic valve LV 9.
A first interface of the second three-way valve LV11 is connected to the negative pressure source 30, a second interface of the second three-way valve LV11 is selectively communicated with the first waste liquid tank 11 through a first three-way electromagnetic valve LV8, and a third interface of the second three-way valve LV11 is selectively communicated with the second waste liquid tank 12 through a second three-way electromagnetic valve LV 9.
Specifically, during use, the positive pressure source 20 is activated, and the first three-way solenoid valve LV8 communicates the second port of the first three-way valve LV10 with the first waste reservoir 11, such that the positive pressure source 20 provides positive pressure to the first waste reservoir 11, and/or the second three-way solenoid valve LV9 communicates the third port of the first three-way valve LV10 with the second waste reservoir 12, such that the positive pressure source 20 provides positive pressure to the second waste reservoir 12.
In the using process, the negative pressure source 30 is started, the first three-way electromagnetic valve LV8 is communicated with the second port of the second three-way valve LV11 and the first waste liquid tank 11, so that the negative pressure source 30 provides negative pressure for the first waste liquid tank 11, so that the cleaning reagent in the liquid supply unit 40 enters the first waste liquid tank 11, and/or the second three-way electromagnetic valve LV9 is communicated with the third port of the second three-way valve LV11 and the second waste liquid tank 12, and the negative pressure source 30 provides negative pressure for the second waste liquid tank 12, so that the cleaning reagent in the liquid supply unit 40 enters the second waste liquid tank 12.
As shown in fig. 3, in an embodiment, the first waste liquid pool 11 is used for collecting a first waste liquid, and the second waste liquid pool 12 is used for collecting a second waste liquid, wherein the first waste liquid and the second waste liquid come from different reaction pools.
The cleaning system 100 further includes a waste liquid treatment unit 50, a second two-way solenoid valve LV5 and a third two-way solenoid valve LV 6.
The first waste liquid pool 11 is selectively communicated with the waste liquid treatment unit 50 through a second two-way electromagnetic valve LV5, and the second waste liquid pool 12 is selectively communicated with the waste liquid treatment unit 50 through a third two-way electromagnetic valve LV 6. The liquid in the first waste liquid tank 11 enters the waste liquid treatment unit 50 from the second two-way electromagnetic valve LV5, and the liquid in the second waste liquid tank 12 enters the waste liquid treatment unit 50 from the third two-way electromagnetic valve LV 6.
Specifically, in a using process, the negative pressure source 30 is activated, the first three-way electromagnetic valve LV8 communicates with the second port of the second three-way valve LV11 and the first waste liquid tank 11, and the negative pressure source 30 provides a negative pressure for the first waste liquid tank 11, so that the cleaning reagent in the liquid supply unit 40 enters the first waste liquid tank 11. And starting the positive pressure source 20, wherein the second three-way electromagnetic valve LV9 is communicated with the third port of the first three-way valve LV10 and the second waste liquid pool 12, and the positive pressure source 20 continuously provides positive pressure for the second waste liquid pool 12. After the pressure inside the first waste liquid tank 11 is stable (at this time, the first waste liquid tank 11 is negative pressure, and the second waste liquid tank 12 is positive pressure), the first three-way electromagnetic valve LV8 is closed (i.e., the negative pressure source 30 is not communicated with the first waste liquid tank 11), the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 are opened briefly (i.e., the first waste liquid tank 11 and the second waste liquid tank 12 are communicated briefly), and at this time, the gas in the second waste liquid tank 12 enters the first waste liquid tank 11, and bubbles are blown out in the cleaning reagent in the first waste liquid tank 11. After the negative pressure of the first waste liquid pool 11 is neutralized (i.e. the cleaning reagent in the first waste liquid pool 11 does not blow bubbles), the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 are closed immediately (i.e. the first waste liquid pool 11 and the second waste liquid pool 12 are not communicated), the first three-way electromagnetic valve LV8 is communicated with the second port of the second three-way electromagnetic valve LV11 and the first waste liquid pool 11, the negative pressure source 30 recovers to provide the negative pressure for the first waste liquid pool 11, after the pressure in the first waste liquid pool 11 is stabilized, the first three-way electromagnetic valve LV8 is closed, the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 are opened briefly, and the above process is repeated to continuously blow bubbles in the first waste liquid pool 11 until the first waste liquid pool 11 is cleaned. In addition, since the second waste liquid tank 12 is maintained at positive pressure, part of the positive pressure neutralizes the negative pressure in the first waste liquid tank 11 to cause the reverse flow of air for bubbling, and the remaining positive pressure is discharged out of the machine by the second two-way electromagnetic valve LV5, thereby preventing the waste liquid in the waste liquid treatment unit 50 from being sucked back into the first waste liquid tank 11 from the outside.
And finally, starting the positive pressure source 20, wherein the first three-way electromagnetic valve LV8 is communicated with the second port of the first three-way valve LV10 and the first waste liquid tank 11, and the second two-way electromagnetic valve LV5 is communicated with the first waste liquid tank 11 and the waste liquid treatment unit 50, at this time, the positive pressure source 20 continuously provides positive pressure for the first waste liquid tank 11 so as to drive the liquid in the first waste liquid tank 11 to be discharged to the waste liquid treatment unit 50.
Further, the negative pressure source 30 is started, the second three-way electromagnetic valve LV9 communicates with the third port of the second three-way valve LV11 and the second waste liquid pool 12, and the negative pressure source 30 provides negative pressure for the second waste liquid pool 12, so that the cleaning reagent in the liquid supply unit 40 enters the second waste liquid pool 12. And starting the positive pressure source 20, wherein the first three-way electromagnetic valve LV8 is communicated with the second port of the first three-way valve LV10 and the first waste liquid pool 11, and the positive pressure source 20 continuously provides positive pressure for the first waste liquid pool 11. After the pressure inside the second waste liquid tank 12 is stable (the first waste liquid tank 11 is positive pressure, and the second waste liquid tank 12 is negative pressure), the second three-way electromagnetic valve LV9 is closed (i.e. the negative pressure source 30 is not communicated with the second waste liquid tank 12), the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 are opened briefly (i.e. the first waste liquid tank 11 and the second waste liquid tank 12 are communicated briefly), at this time, the positive pressure inside the first waste liquid tank 11 enters the second waste liquid tank 12, and the negative pressure inside the second waste liquid tank 12 is neutralized to cause the reverse flow of gas, so that bubbles are blown out in the cleaning reagent. And closing the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 (namely, the first waste liquid pool 11 and the second waste liquid pool 12 are not communicated), communicating the third interface of the second three-way electromagnetic valve LV11 with the second waste liquid pool 12 through the second three-way electromagnetic valve LV9, recovering the negative pressure source 30 to provide negative pressure for the second waste liquid pool 12, closing the second three-way electromagnetic valve LV9 after the pressure in the second waste liquid pool 12 is stabilized, opening the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 for a short time, repeating the above processes, and continuously blowing bubbles in the second waste liquid pool 12 until the second waste liquid pool 12 is cleaned. In addition, since the positive pressure is maintained in the first waste liquid tank 11, part of the positive pressure is used to blow bubbles in the second waste liquid tank 12, and the rest is discharged out of the machine through the third two-way electromagnetic valve LV6, thereby preventing the waste liquid in the waste liquid treatment unit 50 from being sucked back into the second waste liquid tank 12 from the outside.
And finally, starting the positive pressure source 20, wherein the second three-way electromagnetic valve LV9 is communicated with the third interface of the first three-way valve LV10 and the second waste liquid tank 12, and the third two-way electromagnetic valve LV6 is communicated with the second waste liquid tank 12 and the waste liquid treatment unit 50, at this time, the positive pressure source 20 continuously provides positive pressure for the second waste liquid tank 12 to drive the liquid in the second waste liquid tank 12 to be discharged to the waste liquid treatment unit 50.
As shown in fig. 4, in an embodiment, the liquid supply unit 40 further includes: a first reservoir 41 for storing a washing reagent and a second reservoir 42 for storing a diluting solution.
The first liquid storage tank 41 and the second liquid storage tank 42 are selectively communicated with the first liquid inlet of the first waste liquid tank 11 and/or the first liquid inlet of the second waste liquid tank 12.
As shown in fig. 4, in an embodiment, the liquid supply unit 40 further includes: a third three-way solenoid valve LV3, a first two-way solenoid valve LV2 and a fourth three-way solenoid valve LV 1.
The first liquid storage tank 41 is selectively communicated with the first waste liquid tank 11 or the second waste liquid tank 12 sequentially through a third three-way electromagnetic valve LV3, a first two-way electromagnetic valve LV2 and a fourth three-way electromagnetic valve LV 1. The second liquid storage tank 42 is selectively communicated with the first waste liquid tank 11 or the second waste liquid tank 12 sequentially through a third three-way electromagnetic valve LV3, a first two-way electromagnetic valve LV2 and a fourth three-way electromagnetic valve LV 1.
Specifically, during operation, the negative pressure source 30 is activated, and the first reservoir 41 and the first waste liquid reservoir 11 are communicated through the third three-way electromagnetic valve LV3, the first two-way electromagnetic valve LV2 and the fourth three-way electromagnetic valve LV1, so that the cleaning reagent in the first reservoir 41 enters the first waste liquid reservoir 11. Subsequently, the negative pressure source 30 continuously operates to communicate the second liquid storage tank 42 and the first waste liquid tank 11 through the third three-way electromagnetic valve LV3, the first two-way electromagnetic valve LV2 and the fourth three-way electromagnetic valve LV1, so that the diluent in the second liquid storage tank 42 enters the first waste liquid tank 11, and meanwhile, the diluent washes the residual cleaning agent in the pipeline.
Or, in the working process, the negative pressure source 30 is started, and the first liquid storage tank 41 and the second waste liquid tank 12 are communicated through the third three-way electromagnetic valve LV3, the first two-way electromagnetic valve LV2 and the fourth three-way electromagnetic valve LV1, so that the cleaning reagent in the first liquid storage tank 41 enters the second waste liquid tank 12. Subsequently, the negative pressure source 30 continuously operates to communicate the second liquid storage tank 42 and the second waste liquid tank 12 through the third three-way electromagnetic valve LV3, the first two-way electromagnetic valve LV2 and the fourth three-way electromagnetic valve LV1, so that the diluent in the second liquid storage tank 42 enters the second waste liquid tank 12, and meanwhile, the diluent washes the residual cleaning agent in the pipeline.
As shown in fig. 5, in an embodiment, the second liquid inlet of the first waste liquid pool 11 and the second liquid inlet of the second waste liquid pool 12 are used for connecting with a pipeline of the sample analyzer, and when the working negative pressure is established in the first waste liquid pool 11 and/or the second waste liquid pool 12, the waste liquid in the pipeline of the sample analyzer flows into the first waste liquid pool 11 and/or the second waste liquid pool 12.
As shown in fig. 6, the present application also proposes a sample analyzer 100, the sample analyzer 1000 comprising: the cleaning system 100 and the flow reaction apparatus 200 for immunoassay in the above embodiment.
In one embodiment, as shown in FIG. 7, a cleaning method is provided by the present application, which is performed by the cleaning system 100 described above, and which can be applied to any application requiring cleaning of the waste cell unit 10 of the sample analyzer. Specifically, the flow of the cleaning method is as follows:
s11: the first waste reservoir 11 is supplied with negative pressure by a negative pressure source 30 and the second waste reservoir 12 is supplied with positive pressure by a positive pressure source 20.
Specifically, the negative pressure source 30 is started, the first three-way electromagnetic valve LV8 communicates with the second port of the second three-way valve LV11 and the first waste liquid tank 11, and the negative pressure source 30 provides negative pressure for the first waste liquid tank 11, so that the cleaning reagent in the liquid supply unit 40 enters the first waste liquid tank 11. And starting the positive pressure source 20, wherein the second three-way electromagnetic valve LV9 is communicated with the third port of the first three-way valve LV10 and the second waste liquid pool 12, and the positive pressure source 20 continuously provides positive pressure for the second waste liquid pool 12. At this time, the first waste liquid tank 11 is at a negative pressure, and the second waste liquid tank 12 is at a positive pressure.
S12: the first waste liquid tank 11 and the second waste liquid tank 12 are intermittently communicated to bubble out the washing reagent in the first waste liquid tank 11.
Specifically, after the pressure inside the first waste liquid tank 11 is stabilized, the first three-way electromagnetic valve LV8 is closed (i.e., the negative pressure source 30 is not communicated with the first waste liquid tank 11), and the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 are briefly opened (i.e., the first waste liquid tank 11 and the second waste liquid tank 12 are briefly communicated), at this time, the gas in the second waste liquid tank 12 enters the first waste liquid tank 11, and the negative pressure in the first waste liquid tank 11 is neutralized to cause the reverse flow of the gas, thereby bubbling bubbles in the cleaning reagent. Closing the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 (namely, the first waste liquid pool 11 and the second waste liquid pool 12 are not communicated), communicating the second interface of the second three-way electromagnetic valve LV11 with the first waste liquid pool 11 through the first three-way electromagnetic valve LV8, recovering the negative pressure source 30 to provide negative pressure for the first waste liquid pool 11, after the pressure in the first waste liquid pool 11 is stabilized, closing the first three-way electromagnetic valve LV8, opening the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 for a short time, and repeating the above processes to continuously bulge bubbles in the first waste liquid pool 11 until the first waste liquid pool 11 is cleaned.
As shown in fig. 8, in an embodiment, the step S11 includes:
s111: the positive pressure source 20 continuously provides positive pressure for the second waste liquid pool 12, the positive pressure comprises a first positive pressure and a second positive pressure, the first positive pressure is used for neutralizing the negative pressure in the first waste liquid pool 11 and further bubbling air bubbles, and the second positive pressure is used for discharging from a liquid discharge pipeline so as to prevent waste liquid from flowing backwards to enter the first waste liquid pool 11.
Specifically, the positive pressure source 20 continuously provides positive pressure to the second waste reservoir for at least the purpose of: (1) continuously providing positive pressure for the second waste liquid pool so that the gas continuously enters the first waste liquid pool, and neutralizing the negative pressure in the first waste liquid pool to cause the gas to flow reversely so as to continuously bubble in the cleaning reagent; (2) the waste liquid in the waste liquid treatment unit 50 is prevented from being sucked back into the first waste liquid tank.
As shown in fig. 9, in an embodiment, the step S11 further includes:
s112: when the first waste liquid tank 11 and the second waste liquid tank 12 are not communicated, the negative pressure source 20 provides negative pressure to a first preset value for the first waste liquid tank 11, so as to control the size of the blown bubbles.
Specifically, after the second two-way solenoid valve LV5 and the third two-way solenoid valve LV6 are closed (i.e., the first waste liquid tank 11 and the second waste liquid tank 12 are not connected), the negative pressure source 30 recovers to provide negative pressure for the second waste liquid tank 12 until the negative pressure in the second waste liquid tank 12 reaches the first preset value. Wherein, the larger the first preset value is, the larger the size of the blown bubbles is; the smaller the first preset value, the smaller the size of the blown-out bubble.
As shown in fig. 10, in one embodiment, the step S12 includes:
s121: when the negative pressure source 30 supplies the negative pressure to the first waste liquid tank 11 to the first preset value, the first waste liquid tank 11 and the second waste liquid tank 12 are communicated.
Specifically, the negative pressure source 30 returns to provide negative pressure for the second waste liquid pool 12, and when the negative pressure in the second waste liquid pool 12 reaches a first preset value, the first three-way electromagnetic valve LV8 is closed (i.e., the negative pressure source 30 is not communicated with the first waste liquid pool 11), and the second two-way electromagnetic valve LV5 and the third two-way electromagnetic valve LV6 are opened (i.e., the first waste liquid pool 11 and the second waste liquid pool 12 are communicated).
S122: when the connection time is less than or equal to the time required for the first positive pressure and the negative pressure in the first waste liquid tank 11, the connection between the first waste liquid tank 11 and the second waste liquid tank 12 is immediately disconnected.
Specifically, when the connection time between the first waste liquid tank 11 and the second waste liquid tank 12 is less than or equal to the time required for the first positive pressure to neutralize the negative pressure in the first waste liquid tank, the second two-way solenoid valve LV5 and the third two-way solenoid valve LV6 are immediately closed (i.e., the first waste liquid tank 11 and the second waste liquid tank 12 are not connected).
As shown in fig. 11, in an embodiment, before step S11, the method includes:
s13: the waste liquid in the second waste liquid tank 12 is emptied by the positive pressure source 20.
Specifically, the positive pressure source 20 is started, the second three-way solenoid valve LV9 communicates the third port of the first three-way valve LV10 with the second waste liquid pool 12, and the third two-way solenoid valve LV6 communicates the second waste liquid pool 12 with the waste liquid treatment unit 50, at this time, the positive pressure source 20 continuously provides positive pressure to the second waste liquid pool 12 to drive the liquid in the second waste liquid pool 12 to be discharged to the waste liquid treatment unit 50.
S14: the liquid supply unit 40 delivers the cleaning reagent to the first waste liquid tank 11 under the negative pressure.
Specifically, the negative pressure source 30 is activated to communicate the first reservoir 41 and the first waste liquid reservoir 11 through the third three-way electromagnetic valve LV3, the first two-way electromagnetic valve LV2, and the fourth three-way electromagnetic valve LV1, so that the cleaning reagent in the first reservoir 41 enters the first waste liquid reservoir 11.
Compared with the prior art, the method has the following beneficial effects:
the cleaning system of the present application includes: the liquid supply unit provides at least cleaning reagents for the two waste liquid pools, the negative pressure source can provide negative pressure for one of the waste liquid pools, the positive pressure source can continuously provide positive pressure for the other waste liquid pool, the waste liquid pool with the negative pressure and the other waste liquid pool with the positive pressure are intermittently communicated, so that gas in the waste liquid pool with the positive pressure is driven to enter the other waste liquid pool with the negative pressure, bubbles are blown out from the cleaning reagents in the waste liquid pool with the negative pressure, interaction between two or more waste liquid tank bodies is realized by using a positive-negative pressure switching mode, and the cleaning reagents and other liquids (such as diluent) in the waste liquid pool with the negative pressure violently move by blowing the bubbles out, so that the cleaning reagents and other liquids (such as diluent) are fully and uniformly mixed, and the uniformly mixing effect is good; when realizing the cleaning reagent with other liquid (for example diluent) mixing, liquid such as cleaning reagent in the waste liquid pond constantly assaults waste liquid pond inner wall under violent motion to the cleaning performance in waste liquid pond has been promoted.
While the application has been described in the specification and drawings with reference to specific embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the application as defined in the claims. Furthermore, the combination and arrangement of features, elements and/or functions between specific embodiments herein is clearly apparent and thus, in light of this disclosure, one skilled in the art will appreciate that features, elements and/or functions of an embodiment may be incorporated into another embodiment as appropriate, unless described otherwise, above.
In addition, many modifications may be made to adapt a particular situation or material to the teachings of the application without departing from the essential scope thereof. Therefore, it is intended that the present application not be limited to the particular embodiments illustrated by the drawings and described in the specification as the best mode presently contemplated for carrying out the present application, but that the present application will include all embodiments falling within the scope of the foregoing description and the appended claims.
Claims (10)
1. A cleaning system, comprising:
the waste liquid pool unit comprises two waste liquid pools;
the liquid supply unit is used for providing reagents for the two waste liquid pools, and the reagents at least comprise cleaning reagents;
positive pressure source, controllably connecting two said waste liquid pools respectively;
a negative pressure source controllably connecting the two waste liquid pools respectively;
wherein, the negative pressure source is one of them waste liquid pond provides the negative pressure, positive pressure source is one of them another waste liquid pond provides the positive pressure, through intermittently communicate two waste liquid ponds to the bubble is bloated in the washing reagent in the waste liquid pond that has the negative pressure.
2. The cleaning system of claim 1, wherein the waste reservoir unit comprises a first waste reservoir and a second waste reservoir, the first waste reservoir and the second waste reservoir being controllably connected and sharing a set of drain lines, the negative pressure source providing negative pressure to the first waste reservoir and the positive pressure source providing positive pressure to the second waste reservoir.
3. The cleaning system of claim 2, wherein the liquid supply unit is controllably connected to the first and second waste reservoirs, respectively, for providing reagents to the first and second waste reservoirs, the reagents further comprising a diluent.
4. The cleaning system of claim 2, wherein the first waste reservoir is configured to collect a first waste fluid and the second waste reservoir is configured to collect a second waste fluid, the first waste fluid and the second waste fluid being from different reaction reservoirs.
5. A sample analyzer, comprising: a cleaning system according to any one of claims 1 to 4 for use in cleaning a waste reservoir.
6. A cleaning method, characterized in that the cleaning method is based on the cleaning system as claimed in claims 2-4, the cleaning method comprising:
providing negative pressure for the first waste liquid pool through a negative pressure source, and providing positive pressure for the second waste liquid pool through a positive pressure source;
intermittently communicating the first waste liquid pool and the second waste liquid pool to bubble out the washing reagent in the first waste liquid pool.
7. The method of claim 6, wherein the step of providing positive pressure to the second waste reservoir via a positive pressure source comprises:
through the positive pressure source does the second waste liquid pond provides the malleation continuously, the malleation includes first malleation and second malleation, and first malleation is used for neutralizing negative pressure in the first waste liquid pond, and then the bubble of drum out, the second malleation is used for following the fluid-discharge line is discharged to prevent that waste liquid from flowing backward the entering first waste liquid pond.
8. The method of claim 7, wherein the step of providing negative pressure to the first waste reservoir via a negative pressure source comprises:
when the first waste liquid pool and the second waste liquid pool are not communicated, negative pressure is provided for the first waste liquid pool to a first preset value through a negative pressure source, and the negative pressure is used for controlling the size of the blown bubbles.
9. The method of claim 8, wherein the step of intermittently communicating the first waste reservoir and the second waste reservoir to bubble the wash reagent in the first waste reservoir comprises:
when negative pressure is provided for the first waste liquid pool through a negative pressure source to reach a first preset value, communicating the first waste liquid pool with the second waste liquid pool;
and when the communication time is less than or equal to the time required by the first positive pressure and the negative pressure in the first waste liquid pool, immediately disconnecting the first waste liquid pool and the second waste liquid pool.
10. The method of claim 6, wherein prior to the step of providing negative pressure to the first waste reservoir via a negative pressure source, the method further comprises:
emptying the waste liquid in the second waste liquid pool through a positive pressure source;
the liquid supply unit conveys the cleaning reagent to the first waste liquid pool under the action of negative pressure.
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