CN114778870A - Sample analyzer and cleaning method thereof - Google Patents
Sample analyzer and cleaning method thereof Download PDFInfo
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- CN114778870A CN114778870A CN202210662977.4A CN202210662977A CN114778870A CN 114778870 A CN114778870 A CN 114778870A CN 202210662977 A CN202210662977 A CN 202210662977A CN 114778870 A CN114778870 A CN 114778870A
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- 238000004140 cleaning Methods 0.000 title claims abstract description 67
- 238000000034 method Methods 0.000 title claims abstract description 30
- 239000007788 liquid Substances 0.000 claims abstract description 276
- 239000000203 mixture Substances 0.000 claims abstract description 115
- 230000001502 supplementing effect Effects 0.000 claims abstract description 58
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 230000010355 oscillation Effects 0.000 claims description 10
- 239000013589 supplement Substances 0.000 claims description 9
- 238000007599 discharging Methods 0.000 claims description 7
- 238000011010 flushing procedure Methods 0.000 claims description 6
- 239000002699 waste material Substances 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 description 23
- 238000010586 diagram Methods 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 239000004816 latex Substances 0.000 description 3
- 229920000126 latex Polymers 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 108010074051 C-Reactive Protein Proteins 0.000 description 2
- 102100032752 C-reactive protein Human genes 0.000 description 2
- 108700028909 Serum Amyloid A Proteins 0.000 description 2
- 102000054727 Serum Amyloid A Human genes 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
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Abstract
The application provides a sample analyzer and a cleaning method thereof. The sample analyzer includes: the device comprises a liquid supplementing part, a gas conveying part, an intersection piece and a part to be cleaned; the liquid supplementing part is connected with the first end of the junction piece, the gas conveying part is connected with the second end of the junction piece, and the third end of the junction piece is connected with the liquid inlet of the part to be cleaned; the liquid supplementing part is used for inputting liquid to the junction piece; the gas conveying part is used for inputting gas to the junction piece; the intersection piece is used for mixing the gas input by the gas conveying part and the liquid input by the liquid supplementing part to form a gas-liquid mixture, and inputting the gas-liquid mixture to the part to be cleaned so as to clean the part to be cleaned. The utility model provides a sample analyzer's simple structure forms the gas-liquid mixture through the piece that intersects to treat the cleaning part through the gas-liquid mixture and wash, the cleaning performance is better.
Description
Technical Field
The application relates to the field of medical equipment, in particular to a sample analyzer and a cleaning method thereof.
Background
A sample analyzer, such as a blood cell analyzer, belongs to a medical precision instrument, and is required to clean pipelines, instrument parts and a liquid path formed by connecting the pipelines and the instrument parts in the instrument daily or periodically. Specifically, the instrument is cleaned by filling the parts and lines to be cleaned with a cleaning solution to flush any remaining blood and reagent mixture from the instrument's fluid lines.
However, in the existing sample analyzer, the cleaning scheme is not ideal enough, the cleaning effect is not good, and the problem of carrying pollution is possibly caused.
Disclosure of Invention
The application provides a sample analyzer and a cleaning method thereof, which aim to solve the technical problems that in the prior art, the cleaning effect of the sample analyzer is poor and carrying pollution is possibly caused.
In order to solve the technical problem, the application adopts a technical scheme that: there is provided a sample analyzer comprising: the device comprises a liquid supplementing part, a gas conveying part, an intersection piece and a part to be cleaned; the liquid supplementing part is connected with the first end of the junction piece, the gas conveying part is connected with the second end of the junction piece, and the third end of the junction piece is connected with the liquid inlet of the part to be cleaned; the liquid supplementing part is used for inputting liquid to the junction piece; the gas conveying part is used for inputting gas to the junction piece; the intersection piece is used for mixing the gas input by the gas conveying part and the liquid input by the liquid supplementing part to form a gas-liquid mixture, and the gas-liquid mixture is input to the part to be cleaned to clean the part to be cleaned.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a method of cleaning a sample analyzer, the method being based on the sample analyzer of any of the above embodiments, the method comprising: inputting gas to the junction piece through a gas conveying part; inputting liquid to the junction piece through the liquid supplementing part; the gas input by the gas conveying part and the liquid input by the liquid supplementing part are received through the intersection piece to form a gas-liquid mixture, and the part to be cleaned is cleaned through the gas-liquid mixture.
The beneficial effect of this application is: different from the prior art, the sample analyzer comprises a liquid supplementing part, a gas conveying part, an intersection and a part to be cleaned, wherein the liquid supplementing part is connected with a first end of the intersection so as to convey liquid into the intersection, and the gas conveying part is connected with a second end of the intersection so as to convey gas into the intersection, so that a gas-liquid mixture can be formed through the intersection; and the third end of the intersection piece is connected with the liquid inlet of the part to be cleaned so that the gas-liquid mixture can clean the part to be cleaned. Through this kind of mode, the sample analyzer of this application can form the gas-liquid mixture at the intersection at least to utilize the gas-liquid mixture to treat the cleaning part and wash, can improve the cleaning performance of treating the cleaning part.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for the description of the embodiments will be briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
FIG. 1 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 2 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 3 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 4 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 5 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 6 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 7 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 8 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 9 is a schematic flow chart diagram illustrating one embodiment of a method for cleaning a sample analyzer provided herein;
FIG. 10 is a schematic flow chart diagram illustrating one embodiment of a method for cleaning a sample analyzer provided herein;
fig. 11 is a schematic flow chart illustrating an embodiment of a method for cleaning a sample analyzer provided herein.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that if directional indications (such as up, down, left, right, front, and back … …) are referred to in the embodiments of the present application, the directional indications are only used to explain the relative positional relationship between the components, the movement situation, and the like in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description of "first", "second", etc. in the embodiments of the present application, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present application.
This application at first provides a sample analyzer, this sample analyzer simple structure, and can produce the gas-liquid mixture to treat the cleaning part through the gas-liquid mixture and wash, can obviously improve the cleaning performance.
The sample analyzer of the present application may be a blood analyzer including at least one of a blood-specific protein analysis module, a CRP (C-reactive protein) and/or SAA (Serum Amyloid a). The cleaning scheme adopted by the application is better for the blood analyzer with the specific protein analysis module. Because the specific protein analysis module needs to use the latex reagent, and the adhesive force of the latex reagent on the wall of the liquid path pipe is strong, the latex reagent is difficult to clean by the traditional cleaning method, and the technical scheme of the application has an excellent effect in this respect.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sample analyzer 10 provided in the present application, including: a liquid supplementing part 11, a gas conveying part 12, a junction piece 13 and a part to be cleaned 14; the liquid supplementing part 11 is connected with a first end of an intersection piece 13, the gas conveying part 12 is connected with a second end of the intersection piece 13, and a third end of the intersection piece 13 is connected with a liquid inlet of the part to be cleaned 14; the liquid replenishing portion 11 is used for inputting liquid to the junction piece 13; gas delivery section 12 is used to input gas to junction piece 13; the junction 13 is used for mixing the gas input by the gas conveying part 12 and the liquid input by the liquid supplementing part 11 to form a gas-liquid mixture, and the gas-liquid mixture is input to the part to be cleaned 14 to clean the part to be cleaned 14.
The present embodiment mixes the gas input from the gas conveying part 12 with the liquid input from the liquid replenishing part 11 through the junction 13 to form a gas-liquid mixture, and inputs the gas-liquid mixture into the part to be cleaned 14, so as to clean the part to be cleaned 14 with the gas-liquid mixture. Therefore, the sample analyzer 10 of the present embodiment can form the gas-liquid mixture and wash the portion to be washed 14 with the gas-liquid mixture, and the washing effect of the portion to be washed 14 can be improved.
Optionally, the sample analyzer 10 of the present embodiment further includes a first control valve 111 and a second control valve 121, wherein one end of the first control valve 111 is connected to the liquid supplementing portion 11, the other end of the first control valve 111 is connected to the first end of the junction 13, and the first control valve 111 is configured to control communication and closing of the liquid supplementing portion 11 and the junction 13; one end of the second control valve 121 is connected to the gas delivering part 12, the other end of the second control valve 121 is connected to the second end of the intersection 13, and the second control valve 121 is used for controlling the communication and closing of the gas delivering part 12 and the intersection 13.
In this embodiment, the intersection fitting 13 includes a tee fitting, and the tee fitting is connected to the liquid inlet of the portion to be cleaned 14 through a connecting pipe 15. In this embodiment, the liquid supplementing unit 11 inputs liquid to the junction 13, and the gas conveying unit 12 may input gas to the junction 13 to form a gas-liquid mixture through the junction 13, so as to flush the connecting pipeline 15 and the to-be-cleaned unit 14.
The gas conveying part 12 can convey gas to the junction piece 13 and the liquid supplementing part 11 can convey liquid to the junction piece 13 simultaneously or alternatively; the gas delivery unit 12 intermittently delivers the gas to the junction element 13, that is, the second control valve 121 connected to the gas delivery unit 12 is intermittently opened and closed.
In an application scenario, the second control valve 121 may be controlled to open and close intermittently, so that the gas conveying portion 12 intermittently inputs gas to the junction 13 at one or more preset time intervals within a first preset time period, the junction 13 receives the liquid input by the liquid replenishing portion 11 and the gas intermittently input by the gas conveying portion 13 at one or more preset time intervals within the first preset time period, so as to form a gas-liquid mixture with better gas-liquid mixing effect, and the gas-liquid mixture is input to the portion to be cleaned 14 to clean the portion to be cleaned 14 (and the connecting pipeline 15). After the flushing is completed, the second control valve 121 is closed, so that the gas conveying part 12 does not input gas to the junction piece 13 any more; at the same time, the first control valve 111 is closed, so that the liquid replenishing part 11 no longer supplies liquid to the junction element 13.
In another application scenario, the gas delivering part 12 is configured to randomly input the gas to the junction 13 within a first preset time period based on preset supplementary parameters, where the preset supplementary parameters include at least one of supplementary time, supplementary interval, and supplementary pressure; the junction 13 is configured to receive the gas randomly input by the gas conveying portion 12 within a first preset time period, to form a gas-liquid mixture with the liquid input into the junction 13, and to input the gas-liquid mixture into the portion to be cleaned 14 to clean the portion to be cleaned 14. Through the mode, the air can be supplied randomly to form a gas-liquid mixture with better gas-liquid mixing effect, and the cleaning effect is better.
Of course, in other application scenarios, the first control valve 111 may be controlled to open and close intermittently, so that the liquid replenishing part 11 intermittently supplies liquid to the junction element 13. The control of the first control valve 111 can be referred to the second control valve 121.
Optionally, the junction 13 is sealed, so that the gas-liquid mixture at the junction 13 can be driven to the portion to be cleaned 14, and leakage from the junction 13 and pollution can be avoided.
In another embodiment, as shown in fig. 2, different from the embodiment of fig. 1, the sample analyzer 20 of the present embodiment may further include a driving member 16, and the driving member 16 is connected to the portion to be cleaned 14 for discharging the waste flushing liquid in the portion to be cleaned 14 based on the second configuration parameter. The liquid supplementing part 11 and the gas conveying part 12 are used for enabling a gas-liquid mixture at the junction piece 13 to enter the part to be cleaned 14 based on first configuration parameters; wherein the first configuration parameter comprises one or more of a first flow rate, and a first pressure differential, and the second configuration parameter comprises one or more of a second flow rate, and a second pressure differential, and the first flow rate is less than the second flow rate, and/or the first pressure differential is less than the second pressure differential. The driving member 16 is used for rapidly discharging the liquid in the portion to be cleaned 14, so that the stirring degree of the liquid in the portion to be cleaned 14 can be increased, the turbulence formed by the rapidly discharged liquid can be maximized, and the cleaning effect can be enhanced; the driving member 16 is also used for slow refilling of the portion to be cleaned 14, so that the introduction of air bubbles during refilling of the liquid can be reduced, and the adverse effect of the air bubbles on the liquid path reaction can be reduced.
Specifically, as shown in fig. 1, the portion to be cleaned 20 includes a tank body (not shown), and a valve (not shown) and a driving member 16 are disposed at a liquid outlet of the tank body.
When the tank body is flushed, the valve is opened and the flushing waste liquid in the tank body is emptied by the driving piece 16. Wherein, driving piece 16 can be the negative pressure driving piece, takes out the washing waste liquid in with the pond through the negative pressure driving piece fast, can form the effect of managing to find time by force in the pipeline of portion 14 of treating the washing, and the negative pressure will make bubble and the liquid path pipe wall that dissolves in the liquid go up adnexed bubble and enlarge, and because volume change, the bubble of attaching to on the pipe wall drops easily, and dissociates and takes away the bloodiness on the pipe wall by the way, and the cleaning performance is preferred. When the liquid refilling portion 11 refills the tank body with liquid, the valve of the tank body is closed to refill the liquid in the tank body to a desired volume.
In some embodiments, the sample analyzer further comprises: the pressure driving part is directly or indirectly connected with the part to be cleaned and is used for enabling the gas-liquid mixture in the part to be cleaned to go in and out back and forth so as to enable the gas-liquid mixture to oscillate in the part to be cleaned. Through this kind of mode, adjust the pressure size change (two kinds or the pressure switching of multiple size) and the positive negative pressure change (malleation and negative pressure switching) of pressure drive portion, can make the gas-liquid mixture in treating the cleaning portion flow back and forth, thereby make the gas-liquid mixture swing in treating the cleaning portion, can increase the shearing force between gas-liquid mixture and the attached spot on treating the inner wall such as cleaning portion and connecting tube and increase the motion number of times of gas-liquid mixture in treating cleaning portion and connecting tube, make attached spot break because the atress is balanced, thereby drop from the inner wall that attaches more easily, and then can promote the cleaning performance who treats cleaning portion and connecting tube etc..
The pressure driving part comprises one or more of a positive pressure driving part, a negative pressure driving part and a positive pressure driving part.
In a specific embodiment, as shown in fig. 3, unlike the embodiment of fig. 1, the sample analyzer 30 of the present embodiment further includes a pressure driving portion, and the pressure driving portion includes a positive and negative pressure driving member 31, and the positive and negative pressure driving member 31 is connected to the portion to be cleaned 14. The pressure and/or the positive and negative pressure of the positive and negative pressure driving part 31 are adjusted to change, so that the hydraulic pressure and the air pressure in the part to be cleaned 14 can be changed, the gas-liquid mixture in the part to be cleaned 14 flows back and forth, and the gas-liquid mixture oscillates in the part to be cleaned 14.
In another embodiment, as shown in fig. 4, different from the embodiment of fig. 3, in the sample analyzer 40 of this embodiment, the positive/negative pressure driving member 31 is connected to the liquid replenishing portion 11. The pressure of adjusting positive negative pressure drive part 31 changes and/or positive negative pressure changes, can make the interior hydraulic pressure of liquid supplement portion 11 change for liquid in the liquid supplement portion 11 flows back and forth, thereby drives the gas-liquid mixture in the intersection 13 and flows back and forth, and then drives connecting tube 15 and treats the gas-liquid mixture in the portion 14 that washs and flow back and forth, realizes that the gas-liquid mixture is in the portion 14 that washs internal oscillation.
In another embodiment, positive and negative pressure drive members connect the junction members. The pressure size change and/or the positive and negative pressure change of adjusting positive negative pressure drive part can make in the intersection piece hydraulic pressure and atmospheric pressure change for the gas-liquid mixture in the intersection piece flows back and forth, and then drives connecting tube and treats the gas-liquid mixture in the cleaning part and flow back and forth, realizes that gas-liquid mixture shakes in treating the cleaning part.
The intersection piece of this embodiment can also be a four-way pipe, and its first end is connected with liquid supplement portion, and the second end is connected with gas delivery portion, and the third end is connected with the washing portion, and the fourth end is connected with the positive negative pressure drive part that corresponds.
In this embodiment, in a situation where the gas-liquid mixture in the junction oscillates in the junction, the junction receives the liquid delivered by the liquid replenishing portion and receives the gas delivered by the gas delivering portion. The embodiment can realize simultaneous cleaning, fluid infusion and air supplement. In other embodiments, the junction selectively receives liquid delivered by the liquid makeup or gas delivered by the gas delivery section in the event that the gas-liquid mixture within the junction oscillates within the junction.
In other embodiments, under the condition that the gas-liquid mixture in the junction piece oscillates in the junction piece, the junction piece receives the liquid conveyed by the liquid supplementing part and receives the gas input by the gas conveying part, and meanwhile, the valve and the driving part arranged at the liquid outlet of the part to be cleaned are controlled, so that the cleaning, liquid supplementing, gas supplementing and liquid discharging are carried out simultaneously, the distribution of gas-liquid phases in the gas-liquid mixture is more dispersed, the cavitation effect is stronger, and the cleaning efficiency and the cleaning effect are further improved.
In another specific embodiment, the positive and negative pressure driving component is connected with the gas conveying part, the pressure change and/or the positive and negative pressure change of the positive and negative pressure driving component are adjusted, so that the pressure in the gas conveying part can be changed, the gas in the gas conveying part flows back and forth, the gas-liquid mixture in the intersection piece is driven to flow back and forth, the gas-liquid mixture in the connecting pipeline and the part to be cleaned is driven to flow back and forth, and the gas-liquid mixture is vibrated in the part to be cleaned.
A positive pressure driving part or a negative pressure driving part may be used instead of the positive and negative pressure driving part in the above embodiments.
In another embodiment, as shown in fig. 5, unlike the embodiment of fig. 1, the sample analyzer 50 of this embodiment further includes a pressure driving portion 51, and the pressure driving portion 51 is connected between the junction 13 and the portion to be cleaned 14. The pressure driving part 51 may include one or more of a positive pressure driving part, a negative pressure driving part, and a positive pressure driving part.
In this embodiment, the pressure driving portion 51 is disposed between the intersection 13 and the portion to be cleaned 14, and the gas-liquid mixture in the connecting pipeline 15 between the intersection 13 and the portion to be cleaned 14 can flow back and forth by changing the pressure of the pressure driving portion 51 and/or changing the positive pressure and the negative pressure, so that the gas-liquid mixture oscillates in the portion to be cleaned 14.
Of course, in other embodiments, the pressure driving portion may also be connected between the intersection piece and the liquid supplementing portion or between the liquid supplementing portion and the portion to be cleaned, and the oscillation of the gas-liquid mixture in the portion to be cleaned may also be achieved.
In another embodiment, as shown in fig. 6, different from the embodiment of fig. 1, the sample analyzer 60 of this embodiment further includes a pressure driving portion, and the pressure driving portion includes two sub driving portions 61, and the two sub driving portions 61 are respectively connected to the intersection 62 and the liquid supplement portion 11, so as to realize oscillation of the gas-liquid mixture in the intersection 62 and oscillation of the liquid in the liquid supplement portion 11, so as to drive oscillation of the gas-liquid mixture in the connecting pipeline 15 and the portion to be cleaned 14.
The intersection 62 of this embodiment is a four-way pipe, and has a first end connected to the liquid replenishing unit 11, a second end connected to the gas delivering unit 12, a third end connected to the cleaning unit 14 (connecting pipe 15), and a fourth end connected to the corresponding sub-driving unit 61.
In other embodiments, the two sub-driving portions of the pressure driving portion may also be connected to the intersection and the portion to be cleaned, respectively, or connected to the portion to be cleaned and the liquid replenishing portion, respectively.
In other embodiments, the pressure driving portions in the above-described respective embodiments may be used in combination.
Referring to fig. 7, fig. 7 is a schematic structural diagram of an embodiment of a sample analyzer provided in the present application, and unlike the embodiment of fig. 4, the sample analyzer 70 of the present embodiment further includes: a pool device 71; the pool-shaped device 71 is connected with the liquid supplementing part 11 and serves as a spare pool body of the liquid supplementing part 11 to increase the accommodating space of the liquid supplementing part 11, so that the oscillation of the gas-liquid mixture can be performed effectively.
In other embodiments, the pool-shaped device is connected with the part to be cleaned or the intersection piece and is used as a spare pool body of the part to be cleaned or the intersection piece so as to increase the accommodating space of the intersection piece or the part to be cleaned and facilitate the effective oscillation of the gas-liquid mixture; or the part to be cleaned is a pool-shaped device so as to increase the accommodating space of the device, facilitate the effective oscillation of the gas-liquid mixture, and further improve the cleaning effect of the part to be cleaned, the connecting pipeline and the like.
Referring to fig. 8, fig. 8 is a schematic structural diagram of another embodiment of the sample analyzer provided in the present application, and different from the embodiment of fig. 1, in the sample analyzer 80 of the present embodiment, the intersection 81 and the portion to be cleaned 14 are connected by an annular pipeline (not shown), so that a closed loop is formed between the intersection 81 and the portion to be cleaned 14. The annular pipeline is arranged, so that the accommodating space in the oscillation process of the gas-liquid mixture can be increased, the gas-liquid mixture can oscillate in a sufficient space, and the cleaning effect of the part to be cleaned, the connecting pipeline and the like can be further improved.
Similar modifications can be made to the other embodiments described above, and are not described herein.
Referring to fig. 9, fig. 9 is a schematic flow chart of an embodiment of a cleaning method for a sample analyzer provided in the present application, where the cleaning method is based on the sample analyzer in any of the embodiments, and specifically, the cleaning method includes:
step S91: gas is delivered to the intersection by a gas delivery section.
Step S92: and liquid is input into the junction piece through the liquid supplementing part.
Step S93: the gas input by the gas conveying part and the liquid input by the liquid supplementing part are received through the intersection piece to form a gas-liquid mixture, and the part to be cleaned is cleaned through the gas-liquid mixture.
The embodiment washes the part to be cleaned through the generated gas-liquid mixture, and the cleaning effect can be greatly improved.
Specifically, gas is intermittently input to the junction piece through the gas conveying part at one or more preset time intervals within a first preset time period; the liquid input by the liquid supplementing part is received through the intersection piece, the gas input intermittently at one or more preset time intervals by the gas conveying part is received within a first preset time period, so that a gas-liquid mixture is formed, and the part to be cleaned is cleaned through the gas-liquid mixture. After the flushing is finished, controlling the gas conveying part not to input gas to the junction piece any more; and meanwhile, the liquid supplementing part is controlled not to input liquid to the junction piece any more.
In other embodiments, gas is randomly input to the junction over a first predetermined time period by the gas delivery portion based on predetermined replenishment parameters, wherein the predetermined replenishment parameters include at least one of replenishment time, replenishment interval, replenishment pressure; the liquid input by the liquid supplementing part is received through the intersection piece, the gas input randomly by the gas conveying part is received within a first preset time period, so that a gas-liquid mixture is formed, and the part to be cleaned is cleaned through the gas-liquid mixture. In this way, random gas supply can be achieved to form a gas-liquid mixture.
The liquid replenishing step of step S91 and the gas replenishing step of step S92 may be performed simultaneously, and the gas replenishing step of step S92 may be performed intermittently; alternatively, the liquid replenishing step of S91 and the step of S92 are performed alternately.
In another embodiment, as shown in fig. 10, the cleaning method of the present embodiment includes:
step S101: and gas is input to the junction piece through the gas conveying part.
Step S102: liquid is supplied to the junction element through a liquid replenishment portion.
Step S103: the gas input by the gas conveying part and the liquid input by the liquid supplementing part are received through the intersection piece to form a gas-liquid mixture, and the part to be cleaned is cleaned through the gas-liquid mixture.
The specific implementation of step S101 to step S103 can refer to the above-mentioned embodiments.
Step S104: the gas-liquid mixture is oscillated in the portion to be cleaned by the pressure driving portion.
The pressure of the pressure driving portion is adjusted to change in size (pressure switching of two or more sizes) and positive and negative pressure changes (positive pressure and negative pressure switching), so that a gas-liquid mixture in the portion to be cleaned can flow back and forth, the gas-liquid mixture can oscillate in the portion to be cleaned, friction between the gas-liquid mixture and inner walls of the portion to be cleaned, connecting pipelines and the like can be increased, and cleaning effects of the portion to be cleaned, the connecting pipelines and the like can be improved.
In other embodiments, the gas-liquid mixture may also be oscillated between the junction piece and the portion to be cleaned by the pressure driving portion, or within an annular pipe provided between the portion to be cleaned and the liquid replenishing portion by the pressure driving portion.
In another embodiment, based on the above embodiment, the cleaning method of this embodiment further includes: under the condition that the gas-liquid mixture oscillates between the junction piece and the part to be cleaned, in the part to be cleaned and in any one of annular pipelines arranged between the part to be cleaned and the liquid supplementing part, liquid is input into the junction piece through the liquid supplementing part; and/or gas is input to the intersection member through the gas conveying portion under the condition that the gas-liquid mixture oscillates between the intersection member and the portion to be cleaned, in the portion to be cleaned, or in an annular pipeline arranged between the portion to be cleaned and the liquid supplementing portion. By the mode, the cleaning and the liquid and/or gas supplementing can be carried out simultaneously, the random and irregular liquid and/or gas supplementing can enhance the random distribution effect of gas and liquid phases in the gas-liquid mixture, the distribution of the gas and liquid phases in the gas-liquid mixture is more dispersed, the cavitation effect is stronger, and the cleaning efficiency and the cleaning effect are further improved.
In another embodiment, as shown in fig. 11, the cleaning method of the present embodiment includes:
step S111: gas is input to the junction based on the first configuration parameter by a gas delivery section.
The first configuration parameter includes one or more of a first flow rate, and a first pressure differential.
Step S112: and inputting liquid to the junction element through the first configuration parameter of the liquid supplementing part.
Step S113: the gas input by the gas conveying part and the liquid input by the liquid supplementing part are received through the intersection piece to form a gas-liquid mixture, and the part to be cleaned is cleaned through the gas-liquid mixture.
And enabling the gas-liquid mixture at the junction to enter the part to be cleaned through the gas conveying part and the liquid supplementing part based on the first configuration parameters.
Step S114: and discharging the flushing waste liquid in the part to be cleaned based on the second configuration parameter through the driving piece.
The second configuration parameter includes one or more of a second flow rate, and a second pressure differential, the first flow rate being less than the second flow rate, and/or the first pressure differential being less than the second pressure differential.
The driving piece is used for quickly discharging the liquid in the part to be cleaned, so that the stirring degree of the liquid in the part to be cleaned can be increased, the turbulence formed by the quickly discharged liquid is maximized, and the cleaning effect is enhanced; the driving piece is also used for slowly backfilling the part to be cleaned, so that the introduction of bubbles during liquid backfilling can be reduced, and the negative influence of the bubbles on liquid path reaction is reduced.
The cleaning method process of the application is simple, and the cleaning part is washed through the gas-liquid mixture, so that the cleaning effect can be greatly improved.
Different from the prior art, different from the condition of the prior art, the sample analyzer comprises a liquid supplementing part, a gas conveying part, an intersection piece and a part to be cleaned, wherein the liquid supplementing part is connected with a first end of the intersection piece to input liquid into the intersection piece, and the gas conveying part is connected with a second end of the intersection piece to input gas into the intersection piece, so that a gas-liquid mixture with a better gas-liquid mixing effect can be formed through the intersection piece; and the third end of the intersection piece is connected with the liquid inlet of the part to be cleaned so that the gas-liquid mixture can clean the part to be cleaned. Through this kind of mode, the better gas-liquid mixture of gas-liquid mixture effect can be formed to the sample analysis appearance of this application to utilize gas-liquid mixture to treat the cleaning part and wash, can improve the cleaning performance of treating the cleaning part.
The above embodiments are merely examples and are not intended to limit the scope of the present disclosure, and all modifications, equivalents, and flow charts using the contents of the specification and drawings of the present disclosure, which are directly or indirectly applied to other related technical fields, are included in the scope of the present disclosure.
Claims (18)
1. A sample analyzer, the sample analyzer comprising:
the device comprises a liquid supplementing part, a gas conveying part, an intersection piece and a part to be cleaned;
the liquid supplementing part is connected with a first end of the intersection piece, the gas conveying part is connected with a second end of the intersection piece, and a third end of the intersection piece is connected with a liquid inlet of the part to be cleaned;
the liquid replenishing part is used for inputting liquid to the intersection piece;
the gas conveying part is used for inputting gas to the junction piece;
the intersection piece is used for mixing the gas input by the gas conveying part and the liquid input by the liquid supplementing part to form a gas-liquid mixture, and the gas-liquid mixture is input to the part to be cleaned to clean the part to be cleaned.
2. The sample analyzer of claim 1, further comprising a pressure driving part, wherein the pressure driving part is directly or indirectly connected with the part to be cleaned, and the pressure driving part is used for moving the gas-liquid mixture in the part to be cleaned back and forth so as to oscillate the gas-liquid mixture in the part to be cleaned.
3. The sample analyzer of claim 2 wherein the pressure drive includes one or more of a positive pressure drive member, and a negative pressure drive member.
4. The sample analyzer of claim 2 wherein the pressure drive section includes a positive and negative pressure drive member connecting any of the junction, the liquid replenishment section, and the section to be cleaned.
5. The sample analyzer of claim 2 wherein the pressure drive includes two sub-drives, each of which connects any two of the junction, the liquid replenishment portion, and the portion to be cleaned.
6. The sample analyzer of claim 2, wherein the pressure drive is connected between any two of the junction, the liquid replenishment portion, and the portion to be cleaned.
7. The sample analyzer of claim 1, wherein the junction, the liquid supplement portion, or the portion to be cleaned is connected with a pool-like device, or the junction and the portion to be cleaned are connected by a circular pipeline, or the portion to be cleaned is a pool-like device.
8. The sample analyzer of claim 2, further comprising a pressure driver in communication with the junction and configured to move the gas-liquid mixture back and forth within the junction to oscillate the gas-liquid mixture within the junction;
the junction element is further configured to: and under the condition that the gas-liquid mixture in the junction piece oscillates in the junction piece, receiving the liquid conveyed by the liquid supplementing part, and/or under the condition that the gas-liquid mixture in the junction piece oscillates in the junction piece, receiving the gas input by the gas conveying part.
9. The sample analyzer of claim 1, wherein the gas delivery portion is configured to: intermittently delivering gas to the junction at one or more predetermined time intervals over a first predetermined time period;
the junction piece is used for: and receiving the liquid input by the liquid supplementing part and the gas input intermittently by the gas conveying part at one or more preset time intervals within the first preset time period to form the gas-liquid mixture, and inputting the gas-liquid mixture to the part to be cleaned so as to clean the part to be cleaned.
10. The sample analyzer of claim 1, wherein the gas delivery portion is configured to: randomly inputting gas to the junction piece within a first preset time period based on preset supplementary parameters, wherein the preset supplementary parameters comprise at least one of supplementary time, supplementary interval and supplementary pressure;
the junction element is configured to: and receiving gas randomly input by the gas conveying part within the first preset time period to form the gas-liquid mixture with the liquid input into the junction piece, and inputting the gas-liquid mixture into the part to be cleaned to clean the part to be cleaned.
11. The sample analyzer of claim 1,
the liquid replenishing part and the gas delivering part are used for: enabling the gas-liquid mixture at the junction piece to enter the part to be cleaned based on a first configuration parameter;
the sample analyzer further comprises a driving member, the driving member is connected with the part to be cleaned, and the driving member is used for: discharging the flushing waste liquid in the part to be cleaned based on a second configuration parameter;
the first configuration parameter comprises one or more of a first flow rate, and a first pressure differential, the second configuration parameter comprises one or more of a second flow rate, and a second pressure differential, the first flow rate is less than the second flow rate, and/or the first pressure differential is less than the second pressure differential.
12. The sample analyzer of claim 1, wherein the junction is sealingly disposed.
13. A method for cleaning a sample analyzer, based on the sample analyzer of any one of claims 1 to 12, the method comprising:
inputting gas into the junction through the gas delivery section;
inputting liquid to the junction through the liquid supplement portion;
and receiving the gas input by the gas conveying part and the liquid input by the liquid supplementing part through the intersection piece to form a gas-liquid mixture, and cleaning the part to be cleaned through the gas-liquid mixture.
14. The cleaning method of claim 13, wherein the inputting gas to the junction element through the gas delivery section comprises:
intermittently delivering gas to the junction at one or more predetermined time intervals through the gas delivery portion for a first predetermined time period;
the gas input from the gas conveying part and the liquid input from the liquid supplementing part are received through the intersection piece to form a gas-liquid mixture, and the gas-liquid mixture comprises:
and receiving the liquid input by the liquid supplementing part through the junction piece and receiving the gas input intermittently by the gas conveying part at one or more preset time intervals in the first preset time period so as to form the gas-liquid mixture.
15. The cleaning method of claim 13, wherein said inputting gas through said gas delivery section to said junction comprises:
randomly inputting gas to the junction piece within a first preset time period based on preset supplementary parameters, wherein the preset supplementary parameters comprise at least one of supplementary time, supplementary interval and supplementary pressure;
the gas input from the gas conveying part and the liquid input from the liquid supplementing part are received through the intersection piece to form a gas-liquid mixture, and the gas-liquid mixture comprises:
receiving the liquid input by the liquid supplementing part through the intersection piece and receiving the gas input randomly by the gas conveying part within the first preset time period to form the gas-liquid mixture.
16. The cleaning method according to claim 13, wherein the sample analyzer further comprises a pressure driving portion;
the cleaning method further comprises the following steps:
and oscillating the gas-liquid mixture between the junction piece and the part to be cleaned by the pressure driving part, or oscillating the gas-liquid mixture in an annular pipeline arranged between the part to be cleaned and the liquid supplementing part by the pressure driving part.
17. The cleaning method of claim 16, wherein the step of delivering fluid to the junction element via the fluid refill portion further comprises:
the gas-liquid mixture is input into the intersection piece through the liquid supplementing part under the condition of oscillation between the intersection piece and the part to be cleaned, in the part to be cleaned and in any one of annular pipelines arranged between the part to be cleaned and the liquid supplementing part; and/or the presence of a gas in the gas,
the step of inputting gas to the junction element through the gas delivery portion further comprises:
the gas-liquid mixture is fed to the junction member through the gas feed portion under the condition of oscillating in any one of between the junction member and the portion to be cleaned, in the portion to be cleaned, and in an annular pipe provided between the portion to be cleaned and the liquid supplement portion.
18. The cleaning method of claim 13, wherein the sample analyzer further comprises a drive member connected to the portion to be cleaned, the cleaning method further comprising:
enabling a gas-liquid mixture at the junction to enter the part to be cleaned through the gas conveying part and the liquid supplementing part based on a first configuration parameter;
discharging, by the drive, the rinse waste in the portion to be cleaned based on a second configuration parameter;
the first configuration parameter comprises one or more of a first flow rate, and a first pressure differential, the second configuration parameter comprises one or more of a second flow rate, and a second pressure differential, the first flow rate is less than the second flow rate, and/or the first pressure differential is less than the second pressure differential.
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| CN202210662977.4A CN114778870A (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and cleaning method thereof |
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| CN202210662977.4A CN114778870A (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and cleaning method thereof |
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Application publication date: 20220722 |