CN114630842A - 用于癌症治疗的结合her2、nkg2d和cd16的多特异性结合蛋白的药物制剂和剂量方案 - Google Patents

用于癌症治疗的结合her2、nkg2d和cd16的多特异性结合蛋白的药物制剂和剂量方案 Download PDF

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CN114630842A
CN114630842A CN202080075846.5A CN202080075846A CN114630842A CN 114630842 A CN114630842 A CN 114630842A CN 202080075846 A CN202080075846 A CN 202080075846A CN 114630842 A CN114630842 A CN 114630842A
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ser
pharmaceutical formulation
chain variable
variable domain
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格雷戈里·P·常
安·F·张
让-玛丽·库勒洛特
阿斯亚·格林贝格
威廉·哈尼
克里斯托弗·瑞安·摩根
迈克尔·C·奈尔
尼古拉·瓦格曼
罗尼·魏
斯蒂芬·奥尼尔
丹尼尔·法伦
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Dragonfly Therapy Co ltd
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Dragonfly Therapy Co ltd
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Priority to CN202410920352.2A priority Critical patent/CN118924895A/zh
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CN202080075846.5A 2019-08-30 2020-08-28 用于癌症治疗的结合her2、nkg2d和cd16的多特异性结合蛋白的药物制剂和剂量方案 Pending CN114630842A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202410920352.2A CN118924895A (zh) 2019-08-30 2020-08-28 用于癌症治疗的结合her2、nkg2d和cd16的多特异性结合蛋白的药物制剂和剂量方案

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962894047P 2019-08-30 2019-08-30
US62/894,047 2019-08-30
US201962895320P 2019-09-03 2019-09-03
US62/895,320 2019-09-03
US201962916935P 2019-10-18 2019-10-18
US62/916,935 2019-10-18
PCT/US2020/048500 WO2021041878A1 (en) 2019-08-30 2020-08-28 Pharmaceutical formulations and dosage regimens for multi-specific binding proteins that bind her2, nkg2d, and cd16 for cancer treatment

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CN202410920352.2A Division CN118924895A (zh) 2019-08-30 2020-08-28 用于癌症治疗的结合her2、nkg2d和cd16的多特异性结合蛋白的药物制剂和剂量方案

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CN114630842A true CN114630842A (zh) 2022-06-14

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CN202410920352.2A Pending CN118924895A (zh) 2019-08-30 2020-08-28 用于癌症治疗的结合her2、nkg2d和cd16的多特异性结合蛋白的药物制剂和剂量方案

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US (1) US20220195065A1 (https=)
EP (1) EP4021943A4 (https=)
JP (2) JP2022546454A (https=)
KR (1) KR20220054649A (https=)
CN (2) CN114630842A (https=)
AU (1) AU2020337999A1 (https=)
BR (1) BR112022003707A2 (https=)
CA (1) CA3152776A1 (https=)
CL (1) CL2022000495A1 (https=)
CO (1) CO2022003580A2 (https=)
IL (1) IL290871A (https=)
MX (1) MX2022002524A (https=)
PE (1) PE20221404A1 (https=)
WO (1) WO2021041878A1 (https=)

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AU2018219887B2 (en) 2017-02-08 2024-08-15 Dragonfly Therapeutics, LLC Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
CN110944661A (zh) 2017-02-20 2020-03-31 蜻蜓疗法股份有限公司 结合her2、nkg2d和cd16的蛋白质
BR112020015994A2 (pt) 2018-02-08 2020-12-15 Dragonfly Therapeutics, Inc. Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
CA3237846A1 (en) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the nkg2d receptor
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
EP3833392A4 (en) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE
JP7512394B2 (ja) 2020-05-06 2024-07-08 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質
EP4301774A4 (en) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
US20230416402A1 (en) * 2022-03-03 2023-12-28 Dragonfly Therapeutics, Inc. Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16, and her2
AR134292A1 (es) * 2023-11-13 2025-12-17 Dragonfly Therapeutics Inc Métodos para tratar el cáncer mediante el uso de proteínas de unión multiespecíficas que se unen a nkg2d, cd16 y her2

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